PKLR

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a pyruvate kinase that catalyzes the transphosphorylation of phohsphoenolpyruvate into pyruvate and ATP, which is the rate-limiting step of glycolysis. Defects in this enzyme, due to gene mutations or genetic variations, are the common cause of chronic hereditary nonspherocytic hemolytic anemia (CNSHA or HNSHA). Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.19284289
2L-phenylalanine catabolic process (GO:0006559)7.19284289
3L-phenylalanine metabolic process (GO:0006558)6.90346347
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.90346347
5triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.63950875
6protoporphyrinogen IX metabolic process (GO:0046501)6.57516946
7aromatic amino acid family catabolic process (GO:0009074)6.48653594
8protoporphyrinogen IX biosynthetic process (GO:0006782)6.01319852
9tryptophan catabolic process (GO:0006569)5.86727415
10indole-containing compound catabolic process (GO:0042436)5.86727415
11indolalkylamine catabolic process (GO:0046218)5.86727415
12kynurenine metabolic process (GO:0070189)5.75959999
13high-density lipoprotein particle remodeling (GO:0034375)5.68888780
14alpha-linolenic acid metabolic process (GO:0036109)5.68338297
15bile acid biosynthetic process (GO:0006699)5.60097056
16tryptophan metabolic process (GO:0006568)5.52345880
17urea metabolic process (GO:0019627)5.50402329
18urea cycle (GO:0000050)5.50402329
19glyoxylate metabolic process (GO:0046487)5.47105259
20epoxygenase P450 pathway (GO:0019373)5.45560341
21negative regulation of fibrinolysis (GO:0051918)5.31587468
22cysteine metabolic process (GO:0006534)5.27736562
23regulation of cholesterol esterification (GO:0010872)5.19700624
24exogenous drug catabolic process (GO:0042738)5.11265830
25proline metabolic process (GO:0006560)5.10553593
26regulation of fibrinolysis (GO:0051917)5.09548847
27sulfur amino acid catabolic process (GO:0000098)5.09351898
28protein carboxylation (GO:0018214)5.08672777
29peptidyl-glutamic acid carboxylation (GO:0017187)5.08672777
30nitrogen cycle metabolic process (GO:0071941)5.06068134
31regulation of triglyceride catabolic process (GO:0010896)5.05175881
32reverse cholesterol transport (GO:0043691)5.04183871
33phospholipid efflux (GO:0033700)4.97597921
34regulation of protein activation cascade (GO:2000257)4.94031525
35bile acid metabolic process (GO:0008206)4.91439438
36protein-lipid complex remodeling (GO:0034368)4.89688696
37macromolecular complex remodeling (GO:0034367)4.89688696
38plasma lipoprotein particle remodeling (GO:0034369)4.89688696
39serine family amino acid catabolic process (GO:0009071)4.87193417
40complement activation, alternative pathway (GO:0006957)4.85998648
41negative regulation of cholesterol transport (GO:0032375)4.77704054
42negative regulation of sterol transport (GO:0032372)4.77704054
43fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.75909383
44aromatic amino acid family metabolic process (GO:0009072)4.70819199
45lysine metabolic process (GO:0006553)4.70783492
46lysine catabolic process (GO:0006554)4.70783492
47triglyceride homeostasis (GO:0070328)4.65049475
48acylglycerol homeostasis (GO:0055090)4.65049475
49regulation of complement activation (GO:0030449)4.59807206
50omega-hydroxylase P450 pathway (GO:0097267)4.59409830
51homocysteine metabolic process (GO:0050667)4.59323469
52amino-acid betaine metabolic process (GO:0006577)4.51996225
53bile acid and bile salt transport (GO:0015721)4.50937699
54plasma lipoprotein particle assembly (GO:0034377)4.50082361
55tyrosine metabolic process (GO:0006570)4.49272631
56cholesterol efflux (GO:0033344)4.48523386
57cellular ketone body metabolic process (GO:0046950)4.47965203
58negative regulation of fatty acid biosynthetic process (GO:0045717)4.43941885
59alpha-amino acid catabolic process (GO:1901606)4.43822688
60plasma lipoprotein particle clearance (GO:0034381)4.42733011
61porphyrin-containing compound metabolic process (GO:0006778)4.33533182
62cellular glucuronidation (GO:0052695)4.29411947
63glycine metabolic process (GO:0006544)4.27239063
64regulation of plasminogen activation (GO:0010755)4.26903347
65proline biosynthetic process (GO:0006561)4.22968290
66very-low-density lipoprotein particle assembly (GO:0034379)4.21968426
67drug catabolic process (GO:0042737)4.19420670
68oxaloacetate metabolic process (GO:0006107)4.19030185
69porphyrin-containing compound biosynthetic process (GO:0006779)4.16681798
70positive regulation of triglyceride lipase activity (GO:0061365)4.16368079
71positive regulation of lipoprotein lipase activity (GO:0051006)4.16368079
72intestinal cholesterol absorption (GO:0030299)4.15384851
73glutamate metabolic process (GO:0006536)4.15019691
74indolalkylamine metabolic process (GO:0006586)4.14595958
75ethanol oxidation (GO:0006069)4.14043080
76imidazole-containing compound metabolic process (GO:0052803)4.13838927
77ethanol metabolic process (GO:0006067)4.10451780
78serine family amino acid metabolic process (GO:0009069)4.09059667
79coenzyme catabolic process (GO:0009109)4.08499475
80cellular amino acid catabolic process (GO:0009063)4.08492628
81amine catabolic process (GO:0009310)4.06122800
82cellular biogenic amine catabolic process (GO:0042402)4.06122800
83heme metabolic process (GO:0042168)4.05012470
84protein-lipid complex assembly (GO:0065005)4.04409711
85benzene-containing compound metabolic process (GO:0042537)4.02905641
86drug metabolic process (GO:0017144)4.02064940
87erythrocyte maturation (GO:0043249)3.98459354
88low-density lipoprotein particle remodeling (GO:0034374)3.95101076
89cellular modified amino acid catabolic process (GO:0042219)3.92392409
90cholesterol homeostasis (GO:0042632)3.91415068
91arginine metabolic process (GO:0006525)3.90261520
92serine family amino acid biosynthetic process (GO:0009070)3.90032421
93plasma lipoprotein particle organization (GO:0071827)3.88140997
94ketone body metabolic process (GO:1902224)3.87205679
95dicarboxylic acid biosynthetic process (GO:0043650)3.86430205
96negative regulation of erythrocyte differentiation (GO:0045647)3.86075603
97phospholipid homeostasis (GO:0055091)3.85468544
98sterol homeostasis (GO:0055092)3.85344358
99positive regulation of lipid catabolic process (GO:0050996)3.84594560
100glucuronate metabolic process (GO:0019585)3.81035196
101uronic acid metabolic process (GO:0006063)3.81035196
102regulation of bile acid biosynthetic process (GO:0070857)3.80282627
103negative regulation of hemostasis (GO:1900047)3.79443608
104negative regulation of blood coagulation (GO:0030195)3.79443608
105regulation of cholesterol homeostasis (GO:2000188)3.77776116
106flavonoid metabolic process (GO:0009812)3.77281663
107fibrinolysis (GO:0042730)3.77250674
108aldehyde catabolic process (GO:0046185)3.74326751
109blood coagulation, intrinsic pathway (GO:0007597)3.73016821
110heme biosynthetic process (GO:0006783)3.72963301
111cofactor catabolic process (GO:0051187)3.71744217
112lipoprotein metabolic process (GO:0042157)3.69885888
113short-chain fatty acid metabolic process (GO:0046459)3.69499274
114phenylpropanoid metabolic process (GO:0009698)3.68567523
115response to nitrosative stress (GO:0051409)3.67175064
116heme transport (GO:0015886)3.66575477
117tetrapyrrole biosynthetic process (GO:0033014)3.66536399
118oxidative demethylation (GO:0070989)3.66236131
119S-adenosylmethionine metabolic process (GO:0046500)3.65705629
120protein-lipid complex subunit organization (GO:0071825)3.65617610
121negative regulation of lipase activity (GO:0060192)3.63841705
122acetyl-CoA metabolic process (GO:0006084)3.60741229
123carboxylic acid catabolic process (GO:0046395)3.60191772
124organic acid catabolic process (GO:0016054)3.60191772
125tetrahydrofolate metabolic process (GO:0046653)3.56045652
126protein activation cascade (GO:0072376)3.54898940
127regulation of lipoprotein particle clearance (GO:0010984)3.54165685
128oxygen transport (GO:0015671)3.53549084
129gas transport (GO:0015669)3.49785000
130positive regulation of blood coagulation (GO:0030194)3.40914217
131positive regulation of hemostasis (GO:1900048)3.40914217
132acute-phase response (GO:0006953)3.40763263
133regulation of apoptotic cell clearance (GO:2000425)3.39153473
134negative regulation of coagulation (GO:0050819)3.35761748
135glutamine family amino acid biosynthetic process (GO:0009084)3.35617716
136hemoglobin metabolic process (GO:0020027)3.31015418
137negative regulation of wound healing (GO:0061045)3.27303999
138regulation of fatty acid biosynthetic process (GO:0042304)3.23063539
139positive regulation of fatty acid biosynthetic process (GO:0045723)3.17802418

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse8.30200480
2PPARA_22158963_ChIP-Seq_LIVER_Mouse7.23122284
3EGR1_23403033_ChIP-Seq_LIVER_Mouse6.89025041
4E2F7_22180533_ChIP-Seq_HELA_Human6.54245769
5LXR_22158963_ChIP-Seq_LIVER_Mouse6.44961779
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse5.10136476
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.08743801
8PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.92538529
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.98142778
10NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.97767649
11EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.32582318
12FOXM1_23109430_ChIP-Seq_U2OS_Human2.33965549
13HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.32084461
14NCOR1_26117541_ChIP-Seq_K562_Human2.22153561
15TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.06306408
16HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.05953624
17GATA1_22025678_ChIP-Seq_K562_Human2.04057225
18MYC_18555785_ChIP-Seq_MESCs_Mouse2.00237833
19ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.8572919
20TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.96702967
21RBPJ_22232070_ChIP-Seq_NCS_Mouse1.80238041
22EGR1_19374776_ChIP-ChIP_THP-1_Human1.79914799
23MYC_18358816_ChIP-ChIP_MESCs_Mouse1.73518952
24FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.62539106
25FOXA2_19822575_ChIP-Seq_HepG2_Human1.60675764
26CLOCK_20551151_ChIP-Seq_293T_Human1.60308389
27MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.60297506
28E2F4_17652178_ChIP-ChIP_JURKAT_Human1.54644548
29MYC_22102868_ChIP-Seq_BL_Human1.51982666
30PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.50799271
31XRN2_22483619_ChIP-Seq_HELA_Human1.50099317
32* HNF4A_19822575_ChIP-Seq_HepG2_Human1.47858997
33HTT_18923047_ChIP-ChIP_STHdh_Human1.46073593
34E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.42019818
35MYC_19079543_ChIP-ChIP_MESCs_Mouse1.40062719
36KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.34169081
37AR_21909140_ChIP-Seq_LNCAP_Human1.33629064
38MYC_19030024_ChIP-ChIP_MESCs_Mouse1.32906604
39SCL_19346495_ChIP-Seq_HPC-7_Human1.32798310
40THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.32211934
41CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.28607485
42CREB1_15753290_ChIP-ChIP_HEK293T_Human1.28265503
43TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.27940305
44STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.27152648
45SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.26397401
46JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.24664951
47SOX2_27498859_Chip-Seq_STOMACH_Mouse1.24591600
48THAP11_20581084_ChIP-Seq_MESCs_Mouse1.20394727
49ELF1_20517297_ChIP-Seq_JURKAT_Human1.20237912
50NELFA_20434984_ChIP-Seq_ESCs_Mouse1.19159089
51PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.17792001
52SRF_21415370_ChIP-Seq_HL-1_Mouse1.17374352
53DCP1A_22483619_ChIP-Seq_HELA_Human1.16626183
54E2F1_21310950_ChIP-Seq_MCF-7_Human1.16611988
55RXRA_24833708_ChIP-Seq_LIVER_Mouse1.14364245
56TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.12819081
57GATA4_25053715_ChIP-Seq_YYC3_Human1.09790091
58ESR1_15608294_ChIP-ChIP_MCF-7_Human1.08680160
59* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.08528409
60POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.08202448
61STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.08157458
62ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.05453248
63* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.05112661
64ETS1_20019798_ChIP-Seq_JURKAT_Human1.03973600
65MYCN_18555785_ChIP-Seq_MESCs_Mouse1.03316811
66VDR_21846776_ChIP-Seq_THP-1_Human1.02580078
67IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.02212633
68CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.01973147
69CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.99545361
70ZNF263_19887448_ChIP-Seq_K562_Human0.95775273
71GATA1_19941826_ChIP-Seq_K562_Human0.94795148
72KDM5A_27292631_Chip-Seq_BREAST_Human0.93774545
73P68_20966046_ChIP-Seq_HELA_Human0.92491067
74BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.92428457
75TTF2_22483619_ChIP-Seq_HELA_Human0.92112569
76PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.91127912
77ELK3_25401928_ChIP-Seq_HUVEC_Human0.89635369
78KLF4_18555785_ChIP-Seq_MESCs_Mouse0.88756261
79ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.86738503
80GATA2_22383799_ChIP-Seq_G1ME_Mouse0.86128916
81GABP_19822575_ChIP-Seq_HepG2_Human0.85995129
82NANOG_18555785_ChIP-Seq_MESCs_Mouse0.85739086
83ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.85562713
84SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.85173388
85KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.85097239
86IRF8_22096565_ChIP-ChIP_GC-B_Human0.85008767
87PHF8_20622854_ChIP-Seq_HELA_Human0.84988993
88ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.84419535
89* GATA1_19941827_ChIP-Seq_MEL_Mouse0.83948716
90SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.83904507
91TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.82137845
92CTCF_27219007_Chip-Seq_ERYTHROID_Human0.81837902
93PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.81668380
94E2F1_20622854_ChIP-Seq_HELA_Human0.81633770
95RARA_24833708_ChIP-Seq_LIVER_Mouse0.81378643
96SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.81197778
97SPI1_23127762_ChIP-Seq_K562_Human0.79348766
98CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.78905293
99CIITA_25753668_ChIP-Seq_RAJI_Human0.78732508
100AUTS2_25519132_ChIP-Seq_293T-REX_Human0.78549719
101TBX5_21415370_ChIP-Seq_HL-1_Mouse0.77932618
102KAP1_22055183_ChIP-Seq_ESCs_Mouse0.75958055
103RARG_19884340_ChIP-ChIP_MEFs_Mouse0.75341633
104GATA2_19941826_ChIP-Seq_K562_Human0.75300775
105CDX2_20551321_ChIP-Seq_CACO-2_Human0.75276185
106NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.74985326
107BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.74747588
108FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.73121453
109AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.72765292
110SALL4_18804426_ChIP-ChIP_XEN_Mouse0.72353878
111NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.71080177
112GATA6_25053715_ChIP-Seq_YYC3_Human0.69472445
113CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.67058501
114RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.65740683
115Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.65089157
116RARB_24833708_ChIP-Seq_LIVER_Mouse0.64806708
117RAD21_21589869_ChIP-Seq_MESCs_Mouse0.62809477
118BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.62239890
119STAT3_1855785_ChIP-Seq_MESCs_Mouse0.62169692
120* LXR_22292898_ChIP-Seq_THP-1_Human0.60925262
121ESR2_21235772_ChIP-Seq_MCF-7_Human0.59961225
122CEBPB_22108803_ChIP-Seq_LS180_Human0.59820155
123PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.57181198
124FOXA1_25552417_ChIP-Seq_VCAP_Human0.55966569
125FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.55798746
126FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.54755761
127AR_20517297_ChIP-Seq_VCAP_Human0.54189377
128EGR1_19032775_ChIP-ChIP_M12_Human0.54030784
129FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.53842815
130* MYC_19915707_ChIP-ChIP_AK7_Human0.51326768
131* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.50847963
132PPAR_26484153_Chip-Seq_NCI-H1993_Human0.49760838
133PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.49426768
134GATA1_22383799_ChIP-Seq_G1ME_Mouse0.48101408
135P53_21459846_ChIP-Seq_SAOS-2_Human0.47847711
136NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.47400018
137NRF2_20460467_ChIP-Seq_MEFs_Mouse0.47400018
138PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.46533295
139STAT1_17558387_ChIP-Seq_HELA_Human0.46523701
140FOXO3_23340844_ChIP-Seq_DLD1_Human0.46360736
141ESET_19884257_ChIP-Seq_ESCs_Mouse0.46209364
142TAF2_19829295_ChIP-Seq_ESCs_Human0.45336266
143CBP_21632823_ChIP-Seq_H3396_Human0.42896753
144SOX2_20726797_ChIP-Seq_SW620_Human0.42866358
145SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.42196330
146GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.41712552
147PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.41371964
148SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.41358998
149BCOR_27268052_Chip-Seq_Bcells_Human0.41137874
150NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.40822034
151ERG_20517297_ChIP-Seq_VCAP_Human0.38724634
152ESR1_21235772_ChIP-Seq_MCF-7_Human0.38049079
153GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.37733266
154RACK7_27058665_Chip-Seq_MCF-7_Human0.37465903
155SPI1_26923725_Chip-Seq_HPCs_Mouse0.37279239
156ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.37179385
157EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.36707025
158SOX3_22085726_ChIP-Seq_MUSCLE_Mouse0.36122358
159SRY_22984422_ChIP-ChIP_TESTIS_Rat0.36100661
160KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.35871407
161BRD4_27068464_Chip-Seq_AML-cells_Mouse0.35758452

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.29713429
2MP0005360_urolithiasis7.91017402
3MP0005085_abnormal_gallbladder_physiolo6.28568225
4MP0005365_abnormal_bile_salt5.89505474
5MP0008875_abnormal_xenobiotic_pharmacok4.99979745
6MP0003806_abnormal_nucleotide_metabolis4.18287050
7MP0003252_abnormal_bile_duct3.90755083
8MP0010329_abnormal_lipoprotein_level3.62464947
9MP0009840_abnormal_foam_cell3.52971188
10MP0005083_abnormal_biliary_tract3.12639258
11MP0001666_abnormal_nutrient_absorption2.98602962
12MP0005332_abnormal_amino_acid2.66251905
13MP0003195_calcinosis2.58392988
14MP0003191_abnormal_cellular_cholesterol2.25325101
15MP0004019_abnormal_vitamin_homeostasis2.19525184
16MP0000609_abnormal_liver_physiology2.17041111
17MP0003656_abnormal_erythrocyte_physiolo2.09400100
18MP0002118_abnormal_lipid_homeostasis2.07341377
19MP0001545_abnormal_hematopoietic_system1.96573968
20MP0005397_hematopoietic_system_phenotyp1.96573968
21MP0002138_abnormal_hepatobiliary_system1.87654159
22MP0003868_abnormal_feces_composition1.86098150
23MP0005319_abnormal_enzyme/_coenzyme1.78599354
24MP0003111_abnormal_nucleus_morphology1.64948205
25MP0001764_abnormal_homeostasis1.62918011
26MP0009697_abnormal_copulation1.62622177
27MP0005584_abnormal_enzyme/coenzyme_acti1.52371992
28MP0008995_early_reproductive_senescence1.42361134
29MP0004145_abnormal_muscle_electrophysio1.37788255
30MP0005451_abnormal_body_composition1.36123864
31MP0009643_abnormal_urine_homeostasis1.32796480
32MP0000678_abnormal_parathyroid_gland1.29498841
33MP0003011_delayed_dark_adaptation1.25262436
34MP0003186_abnormal_redox_activity1.24562771
35MP0004957_abnormal_blastocyst_morpholog1.19162850
36MP0000598_abnormal_liver_morphology1.17332184
37MP0005636_abnormal_mineral_homeostasis1.15763628
38MP0004147_increased_porphyrin_level1.15541044
39MP0003705_abnormal_hypodermis_morpholog1.14034009
40MP0003693_abnormal_embryo_hatching1.06550122
41MP0010094_abnormal_chromosome_stability1.03717435
42MP0000604_amyloidosis1.01179732
43MP0002396_abnormal_hematopoietic_system1.01103611
44MP0009764_decreased_sensitivity_to1.00540248
45MP0005647_abnormal_sex_gland1.00224619
46MP0000566_synostosis0.99472680
47MP0009763_increased_sensitivity_to0.96297546
48MP0002254_reproductive_system_inflammat0.93926517
49MP0006036_abnormal_mitochondrial_physio0.91001762
50MP0005058_abnormal_lysosome_morphology0.88565571
51MP0005084_abnormal_gallbladder_morpholo0.88288267
52MP0009642_abnormal_blood_homeostasis0.87957593
53MP0001915_intracranial_hemorrhage0.86442291
54MP0008058_abnormal_DNA_repair0.86058522
55MP0008469_abnormal_protein_level0.85611820
56MP0001730_embryonic_growth_arrest0.83876969
57MP0005408_hypopigmentation0.80736023
58MP0009765_abnormal_xenobiotic_induced0.79667073
59MP0005376_homeostasis/metabolism_phenot0.79233889
60MP0002078_abnormal_glucose_homeostasis0.79025193
61MP0002876_abnormal_thyroid_physiology0.77047028
62MP0010368_abnormal_lymphatic_system0.74955272
63MP0003172_abnormal_lysosome_physiology0.73538884
64MP0008775_abnormal_heart_ventricle0.71414933
65MP0005334_abnormal_fat_pad0.69934085
66MP0002971_abnormal_brown_adipose0.68723121
67MP0005266_abnormal_metabolism0.68508717
68MP0003077_abnormal_cell_cycle0.68100240
69MP0009053_abnormal_anal_canal0.67904177
70MP0003959_abnormal_lean_body0.67617516
71MP0005220_abnormal_exocrine_pancreas0.67416078
72MP0005448_abnormal_energy_balance0.65971406
73MP0001756_abnormal_urination0.64325742
74MP0009931_abnormal_skin_appearance0.62756054
75MP0008932_abnormal_embryonic_tissue0.62700774
76MP0008007_abnormal_cellular_replicative0.61179447
77MP0005670_abnormal_white_adipose0.61115056
78MP0005464_abnormal_platelet_physiology0.60608858
79MP0005535_abnormal_body_temperature0.60299554
80MP0001697_abnormal_embryo_size0.60174420
81MP0002822_catalepsy0.59848693
82MP0003329_amyloid_beta_deposits0.59584101
83MP0002086_abnormal_extraembryonic_tissu0.59444166
84MP0008057_abnormal_DNA_replication0.59064075
85MP0002080_prenatal_lethality0.56597330
86MP0002249_abnormal_larynx_morphology0.56575710
87MP0002089_abnormal_postnatal_growth/wei0.56543190
88MP0003718_maternal_effect0.56468484
89MP0004264_abnormal_extraembryonic_tissu0.56354863
90MP0003879_abnormal_hair_cell0.56059095
91MP0004130_abnormal_muscle_cell0.55888860
92MP0006035_abnormal_mitochondrial_morpho0.55302902
93MP0001661_extended_life_span0.54541443
94MP0009278_abnormal_bone_marrow0.52552362
95MP0002136_abnormal_kidney_physiology0.51889798
96MP0009333_abnormal_splenocyte_physiolog0.51370052
97MP0000313_abnormal_cell_death0.50659326
98MP0003690_abnormal_glial_cell0.49987864
99MP0000639_abnormal_adrenal_gland0.49873808
100MP0008872_abnormal_physiological_respon0.49160485
101MP0003699_abnormal_female_reproductive0.48867766
102MP0008873_increased_physiological_sensi0.46263115
103MP0005076_abnormal_cell_differentiation0.46174653
104MP0003984_embryonic_growth_retardation0.44900280
105MP0005395_other_phenotype0.44657217
106MP0003786_premature_aging0.44462252
107MP0003638_abnormal_response/metabolism_0.43594358
108MP0005187_abnormal_penis_morphology0.42905166
109MP0004233_abnormal_muscle_weight0.42122731
110MP0003953_abnormal_hormone_level0.42095958
111MP0002088_abnormal_embryonic_growth/wei0.42019826
112MP0004043_abnormal_pH_regulation0.41892605
113MP0001672_abnormal_embryogenesis/_devel0.41819731
114MP0005380_embryogenesis_phenotype0.41819731
115MP0003567_abnormal_fetal_cardiomyocyte0.41785486
116MP0005410_abnormal_fertilization0.41085035
117MP0000350_abnormal_cell_proliferation0.39891095
118MP0002796_impaired_skin_barrier0.39103667
119MP0002928_abnormal_bile_duct0.37482831
120MP0009115_abnormal_fat_cell0.35882179
121MP0005666_abnormal_adipose_tissue0.35793457
122MP0004782_abnormal_surfactant_physiolog0.35711819
123MP0009672_abnormal_birth_weight0.35271660
124MP0005166_decreased_susceptibility_to0.35147028
125MP0008874_decreased_physiological_sensi0.34887729
126MP0010234_abnormal_vibrissa_follicle0.34821850
127MP0002132_abnormal_respiratory_system0.34721455
128MP0003075_altered_response_to0.34539753
129MP0001243_abnormal_dermal_layer0.34065695
130MP0002970_abnormal_white_adipose0.33030499
131MP0003436_decreased_susceptibility_to0.32682855
132MP0003300_gastrointestinal_ulcer0.32062302
133MP0003724_increased_susceptibility_to0.31782267
134MP0000230_abnormal_systemic_arterial0.29914844
135MP0001845_abnormal_inflammatory_respons0.29094767
136MP0000249_abnormal_blood_vessel0.28416161
137MP0001881_abnormal_mammary_gland0.28317140
138MP0005248_abnormal_Harderian_gland0.28306913
139MP0002837_dystrophic_cardiac_calcinosis0.27604482
140MP0001765_abnormal_ion_homeostasis0.26202553
141MP0000579_abnormal_nail_morphology0.24918442
142MP0006082_CNS_inflammation0.24502589
143MP0001853_heart_inflammation0.24372855
144MP0005167_abnormal_blood-brain_barrier0.24048364

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)7.04094966
2Intrahepatic cholestasis (HP:0001406)7.00695108
3Abnormality of aromatic amino acid family metabolism (HP:0004338)7.00443778
4Hypobetalipoproteinemia (HP:0003563)6.72470278
5Abnormality of monocarboxylic acid metabolism (HP:0010996)6.50674415
6Prolonged partial thromboplastin time (HP:0003645)6.20665834
7Xanthomatosis (HP:0000991)6.15934544
8Hyperlipoproteinemia (HP:0010980)5.19735216
9Hypolipoproteinemia (HP:0010981)4.90091747
10Complement deficiency (HP:0004431)4.77696267
11Hyperammonemia (HP:0001987)4.51458296
12Joint hemorrhage (HP:0005261)4.50525630
13Abnormality of glutamine family amino acid metabolism (HP:0010902)4.42317663
14Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.40909148
15Epidermoid cyst (HP:0200040)4.28582234
16Hyperglycinemia (HP:0002154)4.22008419
17Abnormality of the common coagulation pathway (HP:0010990)4.19756630
18Abnormality of sulfur amino acid metabolism (HP:0004339)4.17650454
19Fat malabsorption (HP:0002630)4.17634351
20Ketosis (HP:0001946)4.15017510
21* Cholecystitis (HP:0001082)4.14134511
22* Abnormal gallbladder physiology (HP:0012438)4.14134511
23Hypoalphalipoproteinemia (HP:0003233)4.07198688
24Abnormality of aspartate family amino acid metabolism (HP:0010899)4.06691859
25* Abnormality of reticulocytes (HP:0004312)4.04865290
26Hypoglycemic coma (HP:0001325)4.01398911
27Hyperglycinuria (HP:0003108)3.98039392
28Abnormality of methionine metabolism (HP:0010901)3.96373481
29Acanthocytosis (HP:0001927)3.93623699
30Abnormality of glycine metabolism (HP:0010895)3.90002464
31Abnormality of serine family amino acid metabolism (HP:0010894)3.90002464
32Conjugated hyperbilirubinemia (HP:0002908)3.88523897
33Abnormality of pyrimidine metabolism (HP:0004353)3.75750879
34* Hyperbilirubinemia (HP:0002904)3.63993986
35Hypercholesterolemia (HP:0003124)3.63697271
36Abnormality of the intrinsic pathway (HP:0010989)3.63156422
37Hypochromic microcytic anemia (HP:0004840)3.53127692
38Abnormality of complement system (HP:0005339)3.49226257
39* Polycythemia (HP:0001901)3.46513722
40Abnormal hemoglobin (HP:0011902)3.46013255
41Poikilocytosis (HP:0004447)3.40186581
42Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.32868676
43Abnormality of fatty-acid metabolism (HP:0004359)3.29240662
44Abnormality of nucleobase metabolism (HP:0010932)3.17693061
45Hepatocellular carcinoma (HP:0001402)3.15111876
46Ketoacidosis (HP:0001993)3.06191755
47Osteomalacia (HP:0002749)3.01691512
48Steatorrhea (HP:0002570)2.97031217
49Metabolic acidosis (HP:0001942)2.95782147
50Delayed CNS myelination (HP:0002188)2.93669115
51Abnormality of serum amino acid levels (HP:0003112)2.88711280
52Abnormality of purine metabolism (HP:0004352)2.88664152
53Increased serum ferritin (HP:0003281)2.79387322
54Increased serum pyruvate (HP:0003542)2.74410056
55Spontaneous abortion (HP:0005268)2.72570839
56Myocardial infarction (HP:0001658)2.71648979
57Truncus arteriosus (HP:0001660)2.70285016
58Seborrheic dermatitis (HP:0001051)2.68736372
59Abnormality of glycolysis (HP:0004366)2.67288303
60Hypoglycemic seizures (HP:0002173)2.66352331
61Malnutrition (HP:0004395)2.66295941
62Skin nodule (HP:0200036)2.60788967
63* Abnormal gallbladder morphology (HP:0012437)2.59288740
64Lethargy (HP:0001254)2.58112610
65Abnormality of dicarboxylic acid metabolism (HP:0010995)2.57751952
66Dicarboxylic aciduria (HP:0003215)2.57751952
67Vascular calcification (HP:0004934)2.53740151
68* Cholelithiasis (HP:0001081)2.51476607
69Systemic lupus erythematosus (HP:0002725)2.48204281
70Gout (HP:0001997)2.46541345
71Abnormal platelet function (HP:0011869)2.45441441
72Impaired platelet aggregation (HP:0003540)2.45441441
73Paralysis (HP:0003470)2.44776398
74Hyperthyroidism (HP:0000836)2.41884484
75Cerebral palsy (HP:0100021)2.39524969
76Diaphragmatic weakness (HP:0009113)2.38380542
77Spastic diplegia (HP:0001264)2.35572182
78Irritability (HP:0000737)2.32728598
79Late onset (HP:0003584)2.32516052
80Cerebral edema (HP:0002181)2.30442650
81Abnormality of the heme biosynthetic pathway (HP:0010472)2.29484527
82Cardiovascular calcification (HP:0011915)2.23234733
83Glomerulonephritis (HP:0000099)2.21981489
84Hypertensive crisis (HP:0100735)2.21942407
85Esophageal varix (HP:0002040)2.21839769
86Brushfield spots (HP:0001088)2.20201826
87Amyloidosis (HP:0011034)2.17955923
88Abnormality of homocysteine metabolism (HP:0010919)2.17767062
89Homocystinuria (HP:0002156)2.17767062
90Sensorimotor neuropathy (HP:0007141)2.17399870
91Hyperinsulinemic hypoglycemia (HP:0000825)2.17373376
92Mitral stenosis (HP:0001718)2.17108116
93Vomiting (HP:0002013)2.15249512
94Hydroxyprolinuria (HP:0003080)2.14948965
95Abnormality of proline metabolism (HP:0010907)2.14948965
96Pancreatitis (HP:0001733)2.14921312
97Menorrhagia (HP:0000132)2.13528416
98Neonatal onset (HP:0003623)2.13233867
99Abnormality of transition element cation homeostasis (HP:0011030)2.13027167
100Generalized aminoaciduria (HP:0002909)2.11696921
101Abnormality of iron homeostasis (HP:0011031)2.09876852
102Epistaxis (HP:0000421)2.09694484
103Prolonged bleeding time (HP:0003010)2.09669312
104Gingival bleeding (HP:0000225)2.09083569
105* Abnormality of the gallbladder (HP:0005264)2.08373846
106Rickets (HP:0002748)2.06779541
107* Reticulocytosis (HP:0001923)2.04346974
108Enlarged kidneys (HP:0000105)2.02856029
109Opisthotonus (HP:0002179)2.02122424
110Hemorrhage of the eye (HP:0011885)2.00878476
111Thrombophlebitis (HP:0004418)2.00639374
112Abnormality of urine glucose concentration (HP:0011016)1.98243202
113Glycosuria (HP:0003076)1.98243202
114Ileus (HP:0002595)1.97473502
115Recurrent gram-negative bacterial infections (HP:0005420)1.96700473
116Nausea (HP:0002018)1.95573009
117Hypoparathyroidism (HP:0000829)1.92918577
118Purpura (HP:0000979)1.92907657
119Abnormal cartilage morphology (HP:0002763)1.92894845
120Nephritis (HP:0000123)1.92813087
121Hypochromic anemia (HP:0001931)1.90796581
122Birth length less than 3rd percentile (HP:0003561)1.90269716
123Bowel incontinence (HP:0002607)1.89995358
124Proximal tubulopathy (HP:0000114)1.86186933
125Pallor (HP:0000980)1.85772835
126Symptomatic seizures (HP:0011145)1.85351956
127Abnormality of vitamin metabolism (HP:0100508)1.83887634
128Alkalosis (HP:0001948)1.83695307
129Abnormality of the Achilles tendon (HP:0005109)1.83114680
130Hyperglycemia (HP:0003074)1.82711132
131Abnormal large intestine physiology (HP:0012700)1.76037396
132Microcytic anemia (HP:0001935)1.75376390
133Neoplasm of the liver (HP:0002896)1.71606184
134Spastic paraparesis (HP:0002313)1.68756626
135Ventricular fibrillation (HP:0001663)1.66544787
136Ankyloglossia (HP:0010296)1.64753426
137Abnormal number of erythroid precursors (HP:0012131)1.63084652
138Orthostatic hypotension (HP:0001278)1.63057194
139Hypophosphatemic rickets (HP:0004912)1.61782991

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK6.74780772
2ERN14.44739681
3SIK14.38826190
4FGFR44.10026250
5TAOK33.44568041
6EEF2K3.43986937
7INSRR2.90186805
8PRPF4B2.86768179
9TTK2.73842234
10MST1R2.71594399
11RIPK42.68871725
12KSR22.68093682
13ERBB42.66421611
14PKN22.65882860
15CDK122.58020136
16CLK12.57188990
17CDC72.53365560
18FRK2.34677778
19FLT32.19868036
20MAPK112.11833358
21SCYL22.09625056
22RAF12.09267862
23MAP2K41.99097644
24TRIB31.88917854
25NTRK31.87271581
26PTK61.69509069
27GRK61.69502230
28PIK3CG1.66731836
29TYK21.66062496
30MAP3K101.60570502
31BUB11.56004474
32PLK41.54630970
33ABL21.50201591
34LATS11.50119200
35KDR1.40160622
36RPS6KB21.34861323
37DAPK21.33181023
38PRKAA21.29407380
39JAK21.28233867
40SMG11.27871873
41BRSK21.22060801
42NME11.21406705
43NME21.20059848
44NEK21.19957684
45NEK91.17158684
46MAP3K111.16962100
47ERBB21.13631893
48MAP3K71.12446953
49MAP2K31.11415787
50WNK41.07313922
51MAP3K31.06753699
52MET1.06054914
53TBK11.05207862
54WEE11.02595924
55EIF2AK11.02556885
56BRSK11.01544890
57BMPR20.99545496
58WNK10.99199755
59BRAF0.94552015
60CDK60.94428667
61TRPM70.92485103
62CCNB10.91278500
63CHEK20.89438896
64KSR10.88847362
65MATK0.87625172
66MAPK40.87274051
67CDK70.87246004
68CHEK10.86371667
69PIM20.85944061
70SRPK10.83976338
71PRKCZ0.83188275
72RIPK10.82470391
73DYRK1B0.81581575
74PIM10.79344721
75MAPK150.78570266
76JAK10.78470084
77STK40.78162022
78FGFR20.77910471
79ATR0.77733695
80CAMK1D0.77275038
81PRKAA10.76736923
82PDK20.75363128
83CDK20.75344344
84TSSK60.75195195
85PINK10.74683768
86MAP3K140.74650609
87CDK10.73634175
88MAP2K60.73624291
89* PRKACG0.70662751
90MAPKAPK50.70330757
91CSK0.69575395
92MAP2K20.68600132
93STK38L0.68596284
94ATM0.68584754
95IRAK30.68359171
96MAPK120.67690117
97GSK3A0.66748731
98EPHB10.64424674
99MAP2K10.63759463
100BRD40.63214699
101PBK0.62632977
102CDK40.62014975
103CSNK2A20.61906015
104PTK20.61882470
105JAK30.61826995
106SGK30.57624434
107PLK10.56922735
108PAK20.56492361
109TIE10.55300434
110MAPKAPK30.54756564
111ALK0.54749719
112CAMK2G0.54304640
113CSNK2A10.53596407
114DYRK30.53593340
115PDPK10.52527314
116TAOK20.51817480
117TGFBR20.51536093
118CSNK1E0.50838012
119IKBKE0.49766076
120SGK10.47893579
121PRKG20.47722420
122RPS6KB10.46573964
123PLK30.45689157
124PRKCQ0.43482954
125ICK0.43357874
126AKT20.43346108
127SIK20.42527800
128MAP3K50.41373486
129GRK10.41276942
130AKT10.39970875
131GSK3B0.39763726
132EPHA30.39513145
133MAPK100.38851918
134MAP3K10.38425436
135RET0.37950608
136AKT30.37914179
137BMX0.37800154
138MAP3K20.37373772
139MAPK140.36539666
140MTOR0.34462532
141PDK10.32847499
142IGF1R0.30725550
143CSF1R0.30684195
144NUAK10.30677600
145TAOK10.30531169
146MAP3K60.29145588
147PRKCA0.28493067
148NEK10.28361774
149EGFR0.27954628
150SGK20.27769074
151STK30.27621707
152CSNK1G10.27060727
153MAPK70.26754199
154PIK3CA0.26715094
155MAP3K80.26178766
156FGFR30.23499652
157EPHA20.22175644
158PDK40.20240053
159PDK30.20240053
160STK100.19363915
161MAPK30.19144240
162PRKCG0.18933399

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.23038404
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.47733522
3Nitrogen metabolism_Homo sapiens_hsa009103.42622516
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.10941003
5Arginine biosynthesis_Homo sapiens_hsa002202.94369505
6Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.67749096
7Tryptophan metabolism_Homo sapiens_hsa003802.66675430
8Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.60619080
9Complement and coagulation cascades_Homo sapiens_hsa046102.53489904
10Fatty acid degradation_Homo sapiens_hsa000712.48298912
11Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.46428899
12Pentose and glucuronate interconversions_Homo sapiens_hsa000402.32487784
13Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.32291664
14Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.19018041
15Butanoate metabolism_Homo sapiens_hsa006502.12010961
16Peroxisome_Homo sapiens_hsa041462.00969392
17Histidine metabolism_Homo sapiens_hsa003401.96320812
18Chemical carcinogenesis_Homo sapiens_hsa052041.95567598
19Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.94651961
20PPAR signaling pathway_Homo sapiens_hsa033201.89537344
21Propanoate metabolism_Homo sapiens_hsa006401.88188991
22Steroid hormone biosynthesis_Homo sapiens_hsa001401.82605378
23Drug metabolism - other enzymes_Homo sapiens_hsa009831.81657958
24Fatty acid metabolism_Homo sapiens_hsa012121.80773743
25Caffeine metabolism_Homo sapiens_hsa002321.75932225
26beta-Alanine metabolism_Homo sapiens_hsa004101.68779763
27Retinol metabolism_Homo sapiens_hsa008301.67566313
28Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.66446353
29Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.62769319
30Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.61249508
31Selenocompound metabolism_Homo sapiens_hsa004501.61186803
32Bile secretion_Homo sapiens_hsa049761.60947626
33Fat digestion and absorption_Homo sapiens_hsa049751.60661874
34Staphylococcus aureus infection_Homo sapiens_hsa051501.56915983
352-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.53151439
36Sulfur metabolism_Homo sapiens_hsa009201.52534943
37Starch and sucrose metabolism_Homo sapiens_hsa005001.46977522
38Phenylalanine metabolism_Homo sapiens_hsa003601.46752487
39Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.43611199
40Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.40309757
41Folate biosynthesis_Homo sapiens_hsa007901.37244308
42Tyrosine metabolism_Homo sapiens_hsa003501.33927042
43* Pyruvate metabolism_Homo sapiens_hsa006201.31005835
44ABC transporters_Homo sapiens_hsa020101.29820894
45Fatty acid elongation_Homo sapiens_hsa000621.28101545
46Cysteine and methionine metabolism_Homo sapiens_hsa002701.25291384
47Steroid biosynthesis_Homo sapiens_hsa001001.20780139
48Cyanoamino acid metabolism_Homo sapiens_hsa004601.14967635
49Vitamin digestion and absorption_Homo sapiens_hsa049771.14534913
50* Carbon metabolism_Homo sapiens_hsa012001.13992965
51* Biosynthesis of amino acids_Homo sapiens_hsa012301.11678434
52Vitamin B6 metabolism_Homo sapiens_hsa007501.10605308
53Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.03891864
54Arginine and proline metabolism_Homo sapiens_hsa003301.01272663
55* Maturity onset diabetes of the young_Homo sapiens_hsa049501.00663340
56Sulfur relay system_Homo sapiens_hsa041220.99556095
57Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.94850553
58Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.92603862
59Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.91280597
60DNA replication_Homo sapiens_hsa030300.87101268
61Glutathione metabolism_Homo sapiens_hsa004800.83895641
62Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.83848652
63Lysine degradation_Homo sapiens_hsa003100.82660765
64One carbon pool by folate_Homo sapiens_hsa006700.81477584
65Glycerolipid metabolism_Homo sapiens_hsa005610.76751261
66* Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.71822431
67Pentose phosphate pathway_Homo sapiens_hsa000300.70531835
68Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.62251625
69Mismatch repair_Homo sapiens_hsa034300.60822758
70Fatty acid biosynthesis_Homo sapiens_hsa000610.57328967
71Other glycan degradation_Homo sapiens_hsa005110.51703796
72* Metabolic pathways_Homo sapiens_hsa011000.48837539
73Galactose metabolism_Homo sapiens_hsa000520.47860706
74Fructose and mannose metabolism_Homo sapiens_hsa000510.43937810
75Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.41142938
76alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.34297724
77Base excision repair_Homo sapiens_hsa034100.30385341
78Cell cycle_Homo sapiens_hsa041100.29587217
79Acute myeloid leukemia_Homo sapiens_hsa052210.27713422
80RNA transport_Homo sapiens_hsa030130.26346361
81Linoleic acid metabolism_Homo sapiens_hsa005910.23998247
82Homologous recombination_Homo sapiens_hsa034400.22892819
83Insulin resistance_Homo sapiens_hsa049310.22708903
84Prion diseases_Homo sapiens_hsa050200.21784050
85Nucleotide excision repair_Homo sapiens_hsa034200.21357429
86Spliceosome_Homo sapiens_hsa030400.20841658
87Adipocytokine signaling pathway_Homo sapiens_hsa049200.20249244
88Glycerophospholipid metabolism_Homo sapiens_hsa005640.19750661
89N-Glycan biosynthesis_Homo sapiens_hsa005100.19171176
90Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.17830455
91mRNA surveillance pathway_Homo sapiens_hsa030150.13688910
92Renin-angiotensin system_Homo sapiens_hsa046140.12702136
93Chronic myeloid leukemia_Homo sapiens_hsa052200.07896746
94Glucagon signaling pathway_Homo sapiens_hsa049220.06939955
95Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.06131148
96Pyrimidine metabolism_Homo sapiens_hsa002400.05878128
97Thyroid cancer_Homo sapiens_hsa052160.04711328
98AMPK signaling pathway_Homo sapiens_hsa041520.03015922
99Mineral absorption_Homo sapiens_hsa049780.01054977
100Ether lipid metabolism_Homo sapiens_hsa00565-0.2328411
101Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.2148005
102Regulation of autophagy_Homo sapiens_hsa04140-0.1883135
103Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.1852057
104Bladder cancer_Homo sapiens_hsa05219-0.1796855
105Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.1684094
106* Insulin signaling pathway_Homo sapiens_hsa04910-0.1588099
107Hepatitis C_Homo sapiens_hsa05160-0.1582801
108African trypanosomiasis_Homo sapiens_hsa05143-0.1565012
109Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.1563662
110Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1475090
111Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1456779
112Protein digestion and absorption_Homo sapiens_hsa04974-0.1365477
113Ovarian steroidogenesis_Homo sapiens_hsa04913-0.1275527
114Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1230970
115Systemic lupus erythematosus_Homo sapiens_hsa05322-0.0646602
116* Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0429850
117Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.0172634

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