PKM

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein involved in glycolysis. The encoded protein is a pyruvate kinase that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate to ADP, generating ATP and pyruvate. This protein has been shown to interact with thyroid hormone and may mediate cellular metabolic effects induced by thyroid hormones. This protein has been found to bind Opa protein, a bacterial outer membrane protein involved in gonococcal adherence to and invasion of human cells, suggesting a role of this protein in bacterial pathogenesis. Several alternatively spliced transcript variants encoding a few distinct isoforms have been reported. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1COPI coating of Golgi vesicle (GO:0048205)6.08710122
2Golgi transport vesicle coating (GO:0048200)6.08710122
3DNA unwinding involved in DNA replication (GO:0006268)5.45303253
4IMP biosynthetic process (GO:0006188)4.87710908
5nuclear pore organization (GO:0006999)4.83773105
6protein localization to endosome (GO:0036010)4.71438790
7regulation of gene silencing by miRNA (GO:0060964)4.70805971
8regulation of gene silencing by RNA (GO:0060966)4.70805971
9regulation of posttranscriptional gene silencing (GO:0060147)4.70805971
10maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.57108408
11nuclear pore complex assembly (GO:0051292)4.50852903
12folic acid-containing compound biosynthetic process (GO:0009396)4.49764497
13regulation of translational fidelity (GO:0006450)4.47897046
14hemidesmosome assembly (GO:0031581)4.47214685
15protein localization to kinetochore (GO:0034501)4.46797667
16protein retention in ER lumen (GO:0006621)4.45892377
17peptidyl-arginine omega-N-methylation (GO:0035247)4.41400800
18pre-miRNA processing (GO:0031054)4.36801332
19regulation of translational termination (GO:0006449)4.29885852
20IMP metabolic process (GO:0046040)4.22837408
21mitotic nuclear envelope disassembly (GO:0007077)4.17305070
22heterochromatin organization (GO:0070828)4.16416895
23retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)4.05680326
24nuclear envelope disassembly (GO:0051081)3.98067364
25membrane disassembly (GO:0030397)3.98067364
26skin morphogenesis (GO:0043589)3.96419008
27cell adhesion mediated by integrin (GO:0033627)3.93724571
28DNA replication-dependent nucleosome assembly (GO:0006335)3.92249310
29DNA replication-dependent nucleosome organization (GO:0034723)3.92249310
30cell-substrate junction assembly (GO:0007044)3.90927611
31paraxial mesoderm development (GO:0048339)3.89059322
32mitotic sister chromatid segregation (GO:0000070)3.83190631
33peptidyl-arginine N-methylation (GO:0035246)3.82554902
34peptidyl-arginine methylation (GO:0018216)3.82554902
35histone arginine methylation (GO:0034969)3.80647030
36nucleobase biosynthetic process (GO:0046112)3.78205465
37activation of Rac GTPase activity (GO:0032863)3.77010348
38DNA replication initiation (GO:0006270)3.74666063
39sister chromatid segregation (GO:0000819)3.73929854
40adherens junction assembly (GO:0034333)3.67497678
41cell-substrate adherens junction assembly (GO:0007045)3.66073188
42focal adhesion assembly (GO:0048041)3.66073188
43DNA duplex unwinding (GO:0032508)3.63318977
44DNA geometric change (GO:0032392)3.62526246
45cytoskeletal anchoring at plasma membrane (GO:0007016)3.58053669
46protein maturation by protein folding (GO:0022417)3.57722015
47regulation of early endosome to late endosome transport (GO:2000641)3.56710107
48spliceosomal tri-snRNP complex assembly (GO:0000244)3.55151310
49DNA strand elongation involved in DNA replication (GO:0006271)3.54500252
50pentose-phosphate shunt (GO:0006098)3.53315726
51regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.51652547
52glucose 6-phosphate metabolic process (GO:0051156)3.51450751
53barbed-end actin filament capping (GO:0051016)3.50903650
54regulation of mammary gland epithelial cell proliferation (GO:0033599)3.47784398
55protein localization to chromosome, centromeric region (GO:0071459)3.39672403
56peptidyl-proline hydroxylation (GO:0019511)3.38277432
57protein hydroxylation (GO:0018126)3.37042540
58positive regulation of SMAD protein import into nucleus (GO:0060391)3.35527772
59DNA strand elongation (GO:0022616)3.32249105
60peptidyl-lysine dimethylation (GO:0018027)3.29452794
61formation of translation preinitiation complex (GO:0001731)3.28063945
62pore complex assembly (GO:0046931)3.26818465
63dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.26452697
64mitotic chromosome condensation (GO:0007076)3.20852738
65mitotic metaphase plate congression (GO:0007080)3.20265764
66negative regulation of histone methylation (GO:0031061)3.20166950
67regulation of spindle organization (GO:0090224)3.15755634
68mitotic nuclear envelope reassembly (GO:0007084)3.14334187
69nuclear envelope reassembly (GO:0031468)3.14334187
70regulation of mitotic spindle organization (GO:0060236)3.13882124
71nucleobase-containing small molecule interconversion (GO:0015949)3.12823777
72negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.11870530
73* glycolytic process (GO:0006096)3.10953819
74purine nucleobase biosynthetic process (GO:0009113)3.10804354
75NADPH regeneration (GO:0006740)3.09911612
76planar cell polarity pathway involved in neural tube closure (GO:0090179)3.09744889
77proline biosynthetic process (GO:0006561)3.08976932
78epithelial cell-cell adhesion (GO:0090136)3.08631369
79nuclear envelope organization (GO:0006998)3.08103438
80dosage compensation (GO:0007549)3.07536156
81regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.07038105
82glucose catabolic process (GO:0006007)3.01375119
83chromatin assembly (GO:0031497)3.01004072
84postreplication repair (GO:0006301)2.99063996
85regulation of histone H3-K9 methylation (GO:0051570)2.98645968
86activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.98101409
87negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.97748643
88basement membrane organization (GO:0071711)2.94639045
89regulation of sister chromatid cohesion (GO:0007063)2.94075061
90cellular protein complex localization (GO:0034629)2.93444450
91positive regulation of nuclease activity (GO:0032075)2.93261420
92vesicle coating (GO:0006901)2.85615141
93regulation of protein heterodimerization activity (GO:0043497)2.85526635
94somatic hypermutation of immunoglobulin genes (GO:0016446)2.85360101
95somatic diversification of immune receptors via somatic mutation (GO:0002566)2.85360101
96regulation of SMAD protein import into nucleus (GO:0060390)2.85087388
97ribosome assembly (GO:0042255)2.84980724
98positive regulation of chromosome segregation (GO:0051984)2.84932941
99stress fiber assembly (GO:0043149)2.83719926
100establishment of apical/basal cell polarity (GO:0035089)2.83247016
101regulation of centrosome cycle (GO:0046605)2.83164415
102protein localization to microtubule (GO:0035372)2.81104309
103regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.81100889
104endoplasmic reticulum unfolded protein response (GO:0030968)2.81005407
105regulation of glucose import in response to insulin stimulus (GO:2001273)2.80746608
106desmosome organization (GO:0002934)2.80672331
107nodal signaling pathway (GO:0038092)2.80010482
108regulation of centriole replication (GO:0046599)2.79141248
109pinocytosis (GO:0006907)2.76200488
110translesion synthesis (GO:0019985)2.75472378
111negative regulation of cell size (GO:0045792)2.75307379
112tRNA aminoacylation for protein translation (GO:0006418)2.74665359
113regulation of chromosome segregation (GO:0051983)2.74054928
114membrane protein ectodomain proteolysis (GO:0006509)2.73520974
115positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.73053196
116metaphase plate congression (GO:0051310)2.72336782
117semaphorin-plexin signaling pathway (GO:0071526)2.72109416
118protein export from nucleus (GO:0006611)2.71348630
119endodermal cell differentiation (GO:0035987)2.71311120
120histone H2A monoubiquitination (GO:0035518)2.70593099
121ER-nucleus signaling pathway (GO:0006984)2.70180479
122positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.69280358
123membrane raft organization (GO:0031579)2.68544097
124telomere maintenance via semi-conservative replication (GO:0032201)2.67768484
125mitotic G1 DNA damage checkpoint (GO:0031571)2.66864258
126DNA conformation change (GO:0071103)2.65803446
127negative regulation of chromosome segregation (GO:0051985)2.65363131
128regulation of nuclease activity (GO:0032069)2.65226561
129positive regulation of RNA splicing (GO:0033120)2.64817011
130establishment of chromosome localization (GO:0051303)2.64542690
131tRNA aminoacylation (GO:0043039)2.64183870
132amino acid activation (GO:0043038)2.64183870
133NLS-bearing protein import into nucleus (GO:0006607)2.64129831
134regulation of gene silencing (GO:0060968)2.63566016
135establishment of integrated proviral latency (GO:0075713)2.63357866
136regulation of helicase activity (GO:0051095)2.62673779
137glucocorticoid receptor signaling pathway (GO:0042921)2.62406095
138branching involved in mammary gland duct morphogenesis (GO:0060444)2.58598122
139maternal placenta development (GO:0001893)2.58407385
140cortical actin cytoskeleton organization (GO:0030866)2.58226474
141negative regulation of mitotic sister chromatid segregation (GO:0033048)2.58108230
142negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.58108230
143negative regulation of sister chromatid segregation (GO:0033046)2.58108230
144negative regulation of mitotic sister chromatid separation (GO:2000816)2.58108230
145cellular response to unfolded protein (GO:0034620)2.58106014
146mitotic spindle assembly checkpoint (GO:0007094)2.58006482
147regulation of hippo signaling (GO:0035330)2.57485403
148chaperone-mediated protein complex assembly (GO:0051131)2.57084516
149establishment of viral latency (GO:0019043)2.56114848
150negative regulation of RNA splicing (GO:0033119)2.56044194
151positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling2.55814485
152regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway 2.55814485
153negative regulation of DNA repair (GO:0045738)2.55787686
154spindle assembly checkpoint (GO:0071173)2.54719881
155mRNA transport (GO:0051028)2.54382316
156polarized epithelial cell differentiation (GO:0030859)2.54081800
157positive regulation of blood vessel endothelial cell migration (GO:0043536)2.54042739
158apoptotic process involved in morphogenesis (GO:0060561)2.54038917
159chromosome condensation (GO:0030261)2.53858772
160regulation of translational elongation (GO:0006448)2.53046961
161endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.52786728
162ribosome biogenesis (GO:0042254)2.52469684
163mRNA stabilization (GO:0048255)2.52261178
164RNA stabilization (GO:0043489)2.52261178
165negative regulation of gene silencing (GO:0060969)2.51955948
166protein complex localization (GO:0031503)2.51139355
167hypotonic response (GO:0006971)2.48545432
168positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.46821983
169endothelial cell chemotaxis (GO:0035767)2.46574995
1704-hydroxyproline metabolic process (GO:0019471)2.43865785
171mitotic cytokinesis (GO:0000281)2.42600359
172apoptotic cell clearance (GO:0043277)2.42346257
173cellular copper ion homeostasis (GO:0006878)2.41730536
174mammary gland epithelial cell proliferation (GO:0033598)2.41071428
175mesodermal cell differentiation (GO:0048333)2.39961146
176regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.39747842
177endothelial cell morphogenesis (GO:0001886)2.38238311
178negative regulation of chondrocyte differentiation (GO:0032331)2.37257935
179regulation of protein export from nucleus (GO:0046825)2.34757596

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.76810407
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.92869287
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.67741841
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.53899465
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.26024429
6EGR1_19374776_ChIP-ChIP_THP-1_Human3.12566911
7MYC_19079543_ChIP-ChIP_MESCs_Mouse3.02061839
8* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.56315215
9RARG_19884340_ChIP-ChIP_MEFs_Mouse2.54780763
10MYC_22102868_ChIP-Seq_BL_Human2.44304563
11POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.39601913
12MYC_19030024_ChIP-ChIP_MESCs_Mouse2.39385388
13ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.35791473
14TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.26587163
15KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.24482313
16NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.20418110
17NELFA_20434984_ChIP-Seq_ESCs_Mouse2.18891087
18XRN2_22483619_ChIP-Seq_HELA_Human2.16928389
19MYC_18358816_ChIP-ChIP_MESCs_Mouse2.11821648
20NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.07933974
21SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.00393748
22NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.99772773
23ESR1_15608294_ChIP-ChIP_MCF-7_Human1.98767092
24MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.95526993
25RACK7_27058665_Chip-Seq_MCF-7_Human1.90948713
26AR_21909140_ChIP-Seq_LNCAP_Human1.89850281
27LXR_22292898_ChIP-Seq_THP-1_Human1.89614644
28E2F1_21310950_ChIP-Seq_MCF-7_Human1.88157586
29RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.85093048
30HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.82238126
31ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.81687146
32NANOG_18555785_ChIP-Seq_MESCs_Mouse1.81017310
33HIF1A_21447827_ChIP-Seq_MCF-7_Human1.74201162
34MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.72888783
35CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.72781082
36P300_27058665_Chip-Seq_ZR-75-30cells_Human1.69608162
37MYCN_18555785_ChIP-Seq_MESCs_Mouse1.67509985
38HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.66036407
39ZFP281_18757296_ChIP-ChIP_E14_Mouse1.65275180
40SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.65233319
41THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.64680905
42ETS1_20019798_ChIP-Seq_JURKAT_Human1.64618801
43POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.64054205
44CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.59076666
45SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.56635901
46CIITA_25753668_ChIP-Seq_RAJI_Human1.55993072
47THAP11_20581084_ChIP-Seq_MESCs_Mouse1.55735019
48KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.55226759
49WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.55058887
50CREB1_15753290_ChIP-ChIP_HEK293T_Human1.52404815
51EST1_17652178_ChIP-ChIP_JURKAT_Human1.52388385
52ZFX_18555785_ChIP-Seq_MESCs_Mouse1.51440901
53STAT3_1855785_ChIP-Seq_MESCs_Mouse1.50719638
54E2F1_18555785_ChIP-Seq_MESCs_Mouse1.50178610
55TRIM28_21343339_ChIP-Seq_HEK293_Human1.49875607
56KDM2B_26808549_Chip-Seq_SUP-B15_Human1.49862549
57TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.48220425
58KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.47073306
59TTF2_22483619_ChIP-Seq_HELA_Human1.46503186
60TCF3_18692474_ChIP-Seq_MEFs_Mouse1.46094479
61SOX2_18555785_ChIP-Seq_MESCs_Mouse1.44667604
62UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.44529345
63TP63_17297297_ChIP-ChIP_HaCaT_Human1.43711890
64SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.42595563
65YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.41219845
66PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.39090690
67TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.37560596
68TFEB_21752829_ChIP-Seq_HELA_Human1.35485561
69SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.35238516
70PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.34821822
71TCF7_22412390_ChIP-Seq_EML_Mouse1.34430103
72KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.33916544
73KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.33916544
74KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.33916544
75SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.33029482
76SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.33029482
77VDR_21846776_ChIP-Seq_THP-1_Human1.32679688
78STAT6_21828071_ChIP-Seq_BEAS2B_Human1.32355006
79UBF1/2_26484160_Chip-Seq_HMECs_Human1.32332482
80KLF4_18555785_ChIP-Seq_MESCs_Mouse1.31727079
81TP53_22127205_ChIP-Seq_IMR90_Human1.30850838
82CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.29339360
83DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.28842664
84POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.27998178
85GABP_19822575_ChIP-Seq_HepG2_Human1.27887226
86SRY_22984422_ChIP-ChIP_TESTIS_Rat1.27485518
87TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.26933533
88CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.26736430
89NANOG_21062744_ChIP-ChIP_HESCs_Human1.26191870
90ESR2_21235772_ChIP-Seq_MCF-7_Human1.25739172
91KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.25472992
92KDM5A_27292631_Chip-Seq_BREAST_Human1.25435220
93TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.23859065
94TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.23207016
95DCP1A_22483619_ChIP-Seq_HELA_Human1.18914883
96KDM2B_26808549_Chip-Seq_K562_Human1.18640053
97ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.18149252
98NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.17859672
99JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.16927150
100SALL1_21062744_ChIP-ChIP_HESCs_Human1.16880512
101ZFP281_27345836_Chip-Seq_ESCs_Mouse1.14589612
102ATF3_27146783_Chip-Seq_COLON_Human1.14086281
103PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.13554561
104ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.13478327
105NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.12392292
106OCT4_18692474_ChIP-Seq_MEFs_Mouse1.11891721
107TET1_21451524_ChIP-Seq_MESCs_Mouse1.11760475
108SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.10689791
109FOXP3_21729870_ChIP-Seq_TREG_Human1.10661930
110TP63_19390658_ChIP-ChIP_HaCaT_Human1.09232360
111NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.09102564
112TCF3_18692474_ChIP-Seq_MESCs_Mouse1.08909576
113EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.08258094
114NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.08140319
115TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.07303250
116ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.06780537
117CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.06092051
118SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.05378595
119CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.04605339
120VDR_23849224_ChIP-Seq_CD4+_Human1.04378082
121KDM2B_26808549_Chip-Seq_DND41_Human1.04260598
122ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.04235054
123PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.03391497
124TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.02748299
125TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.01512718
126CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.01459023
127EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.01308544
128FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.01093957
129ELK3_25401928_ChIP-Seq_HUVEC_Human1.00507993
130EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.98424364
131KDM2B_26808549_Chip-Seq_JURKAT_Human0.98102166
132E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.97429848
133CTCF_27219007_Chip-Seq_ERYTHROID_Human0.96061383
134POU5F1_16518401_ChIP-PET_MESCs_Mouse0.95744331
135SOX2_18692474_ChIP-Seq_MEFs_Mouse0.94786714
136KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.94631319
137NCOR1_26117541_ChIP-Seq_K562_Human0.94155471
138KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.93839039
139DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.93521470
140ZNF263_19887448_ChIP-Seq_K562_Human0.92716638
141SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.92658102
142SOX2_18692474_ChIP-Seq_MESCs_Mouse0.92644560
143TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.91287312
144GABP_17652178_ChIP-ChIP_JURKAT_Human0.91054156
145NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.90594186
146KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.90375970
147CLOCK_20551151_ChIP-Seq_293T_Human0.90179040

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003111_abnormal_nucleus_morphology3.24929761
2MP0010352_gastrointestinal_tract_polyps3.11209657
3MP0004957_abnormal_blastocyst_morpholog3.07014855
4MP0010094_abnormal_chromosome_stability3.06591462
5MP0003705_abnormal_hypodermis_morpholog2.99404981
6MP0003123_paternal_imprinting2.88538821
7MP0003077_abnormal_cell_cycle2.83030038
8MP0005257_abnormal_intraocular_pressure2.82513351
9MP0003693_abnormal_embryo_hatching2.82359543
10MP0010030_abnormal_orbit_morphology2.70436445
11MP0005076_abnormal_cell_differentiation2.52535370
12MP0010307_abnormal_tumor_latency2.51943485
13MP0001730_embryonic_growth_arrest2.50174289
14MP0002653_abnormal_ependyma_morphology2.41680898
15MP0003283_abnormal_digestive_organ2.33833231
16MP0004233_abnormal_muscle_weight2.31350049
17MP0005451_abnormal_body_composition2.14731658
18MP0008007_abnormal_cellular_replicative2.14710434
19MP0000350_abnormal_cell_proliferation2.10398309
20MP0000537_abnormal_urethra_morphology2.10145116
21MP0002084_abnormal_developmental_patter1.94404647
22MP0008932_abnormal_embryonic_tissue1.91705443
23MP0010234_abnormal_vibrissa_follicle1.87486946
24MP0001348_abnormal_lacrimal_gland1.87162952
25MP0003121_genomic_imprinting1.86307419
26MP0005623_abnormal_meninges_morphology1.86095960
27MP0002060_abnormal_skin_morphology1.82221332
28MP0001697_abnormal_embryo_size1.80471809
29MP0004197_abnormal_fetal_growth/weight/1.80092870
30MP0002085_abnormal_embryonic_tissue1.80077374
31MP0005058_abnormal_lysosome_morphology1.79780384
32MP0001672_abnormal_embryogenesis/_devel1.79000142
33MP0005380_embryogenesis_phenotype1.79000142
34MP0003453_abnormal_keratinocyte_physiol1.78645662
35MP0003566_abnormal_cell_adhesion1.73661317
36MP0000579_abnormal_nail_morphology1.72642849
37MP0003984_embryonic_growth_retardation1.66304677
38MP0003890_abnormal_embryonic-extraembry1.64431121
39MP0001849_ear_inflammation1.63731893
40MP0002088_abnormal_embryonic_growth/wei1.63155600
41MP0002080_prenatal_lethality1.63052933
42MP0008260_abnormal_autophagy1.58242091
43MP0003119_abnormal_digestive_system1.55929006
44MP0004133_heterotaxia1.53983412
45MP0004185_abnormal_adipocyte_glucose1.53917735
46MP0008058_abnormal_DNA_repair1.49415533
47MP0008057_abnormal_DNA_replication1.49058652
48MP0002086_abnormal_extraembryonic_tissu1.46404212
49MP0005501_abnormal_skin_physiology1.43127737
50MP0000733_abnormal_muscle_development1.41992960
51MP0000762_abnormal_tongue_morphology1.41682040
52MP0003329_amyloid_beta_deposits1.40759348
53MP0002796_impaired_skin_barrier1.39592738
54MP0004084_abnormal_cardiac_muscle1.37514340
55MP0003191_abnormal_cellular_cholesterol1.36120254
56MP0000003_abnormal_adipose_tissue1.30913311
57MP0008877_abnormal_DNA_methylation1.30135306
58MP0002877_abnormal_melanocyte_morpholog1.29849659
59MP0000428_abnormal_craniofacial_morphol1.26764356
60MP0000747_muscle_weakness1.26021619
61MP0005023_abnormal_wound_healing1.25841873
62MP0009840_abnormal_foam_cell1.23976536
63MP0009053_abnormal_anal_canal1.23086275
64MP0001293_anophthalmia1.22342533
65MP0002234_abnormal_pharynx_morphology1.21045142
66MP0005409_darkened_coat_color1.20949918
67MP0003300_gastrointestinal_ulcer1.20746114
68MP0002896_abnormal_bone_mineralization1.20098843
69MP0001958_emphysema1.18327864
70MP0000750_abnormal_muscle_regeneration1.13019512
71MP0001216_abnormal_epidermal_layer1.10891875
72MP0002089_abnormal_postnatal_growth/wei1.07287774
73MP0003122_maternal_imprinting1.06753685
74MP0003941_abnormal_skin_development1.05060253
75MP0006072_abnormal_retinal_apoptosis1.04093592
76MP0000313_abnormal_cell_death1.02415473
77MP0008438_abnormal_cutaneous_collagen1.02387153
78MP0002111_abnormal_tail_morphology1.02347828
79MP0003115_abnormal_respiratory_system1.01469887
80MP0004808_abnormal_hematopoietic_stem1.00372126
81MP0000534_abnormal_ureter_morphology1.00291835
82MP0009672_abnormal_birth_weight0.99119550
83MP0003567_abnormal_fetal_cardiomyocyte0.98367269
84MP0003861_abnormal_nervous_system0.98243428
85MP0002697_abnormal_eye_size0.97706340
86MP0005197_abnormal_uvea_morphology0.96668325
87MP0000678_abnormal_parathyroid_gland0.96309119
88MP0001243_abnormal_dermal_layer0.95903433
89MP0002269_muscular_atrophy0.93965243
90MP0000749_muscle_degeneration0.93522741
91MP0001915_intracranial_hemorrhage0.93475109
92MP0005275_abnormal_skin_tensile0.93007849
93MP0002925_abnormal_cardiovascular_devel0.90428908
94MP0000467_abnormal_esophagus_morphology0.90230978
95MP0000358_abnormal_cell_content/0.89430413
96MP0005384_cellular_phenotype0.88870922
97MP0003937_abnormal_limbs/digits/tail_de0.88819844
98MP0005621_abnormal_cell_physiology0.87743393
99MP0003091_abnormal_cell_migration0.87659551
100MP0000767_abnormal_smooth_muscle0.86611506
101MP0004858_abnormal_nervous_system0.85700592
102MP0009780_abnormal_chondrocyte_physiolo0.84669457
103MP0003385_abnormal_body_wall0.83406876
104MP0004947_skin_inflammation0.83235949
105MP0004510_myositis0.83008557
106MP0003950_abnormal_plasma_membrane0.82304471
107MP0005165_increased_susceptibility_to0.81072968
108MP0005394_taste/olfaction_phenotype0.81003829
109MP0005499_abnormal_olfactory_system0.81003829
110MP0010771_integument_phenotype0.80856782
111MP0002019_abnormal_tumor_incidence0.80854933
112MP0008770_decreased_survivor_rate0.80699034
113MP0003942_abnormal_urinary_system0.79471957
114MP0009703_decreased_birth_body0.79433378
115MP0000627_abnormal_mammary_gland0.79247425
116MP0004272_abnormal_basement_membrane0.79025937
117MP0003315_abnormal_perineum_morphology0.78942232
118MP0000569_abnormal_digit_pigmentation0.78432890
119MP0003221_abnormal_cardiomyocyte_apopto0.76981694
120MP0000490_abnormal_crypts_of0.76638566
121MP0003935_abnormal_craniofacial_develop0.75993027
122MP0003634_abnormal_glial_cell0.75979599
123MP0005330_cardiomyopathy0.75978478
124MP0008789_abnormal_olfactory_epithelium0.75373079
125MP0005375_adipose_tissue_phenotype0.74935535
126MP0003448_altered_tumor_morphology0.74683129
127MP0000858_altered_metastatic_potential0.73231385
128MP0004087_abnormal_muscle_fiber0.73082000
129MP0000266_abnormal_heart_morphology0.72377593
130MP0003279_aneurysm0.72315645
131MP0009278_abnormal_bone_marrow0.69765772
132MP0002092_abnormal_eye_morphology0.68473837
133MP0010630_abnormal_cardiac_muscle0.68097767
134MP0001299_abnormal_eye_distance/0.67332149
135MP0003787_abnormal_imprinting0.67021579
136MP0000751_myopathy0.66104859
137MP0000759_abnormal_skeletal_muscle0.64529116
138MP0000432_abnormal_head_morphology0.63226338
139MP0005391_vision/eye_phenotype0.62017500
140MP0002081_perinatal_lethality0.61754519
141MP0002751_abnormal_autonomic_nervous0.61389072

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)5.08748658
2Ependymoma (HP:0002888)4.54185058
3Abnormality of the astrocytes (HP:0100707)3.78583509
4Astrocytoma (HP:0009592)3.78583509
5Vertebral compression fractures (HP:0002953)3.33634774
6Distal lower limb amyotrophy (HP:0008944)3.26071927
7Selective tooth agenesis (HP:0001592)3.08133097
8Atrophic scars (HP:0001075)3.07218267
9Short nail (HP:0001799)3.00628542
10Achilles tendon contracture (HP:0001771)2.92983996
11Ulnar bowing (HP:0003031)2.89220308
12Osteolytic defects of the phalanges of the hand (HP:0009771)2.87826729
13Osteolytic defects of the hand bones (HP:0009699)2.87826729
14Glioma (HP:0009733)2.86255208
15Agnosia (HP:0010524)2.85570280
16Increased connective tissue (HP:0009025)2.82345165
17Medulloblastoma (HP:0002885)2.79737465
18Broad face (HP:0000283)2.77251061
19Hyperacusis (HP:0010780)2.74477055
20Abnormality of the labia minora (HP:0012880)2.73488205
21Distal lower limb muscle weakness (HP:0009053)2.70633851
22Fragile skin (HP:0001030)2.68934091
23Colon cancer (HP:0003003)2.67881416
24Hand muscle atrophy (HP:0009130)2.66949546
25Exercise-induced muscle cramps (HP:0003710)2.65986690
26Lower limb amyotrophy (HP:0007210)2.60894822
27Deviation of the thumb (HP:0009603)2.60561587
28Spinal rigidity (HP:0003306)2.60468358
29Abnormality of the Achilles tendon (HP:0005109)2.56217604
30Cholecystitis (HP:0001082)2.54092383
31Abnormal gallbladder physiology (HP:0012438)2.54092383
32Missing ribs (HP:0000921)2.53206963
33Distal upper limb amyotrophy (HP:0007149)2.53053919
34Upper limb amyotrophy (HP:0009129)2.53053919
35Renal duplication (HP:0000075)2.52193248
36Arterial tortuosity (HP:0005116)2.52090351
37Adenoma sebaceum (HP:0009720)2.48549904
38Angiofibromas (HP:0010615)2.48549904
39Proximal placement of thumb (HP:0009623)2.44420893
40Wormian bones (HP:0002645)2.44026453
41Increased nuchal translucency (HP:0010880)2.43564793
42Abnormality of the lower motor neuron (HP:0002366)2.42672343
43Abdominal situs inversus (HP:0003363)2.42484621
44Abnormality of abdominal situs (HP:0011620)2.42484621
45Long palpebral fissure (HP:0000637)2.41148203
46Pointed chin (HP:0000307)2.39373265
47Shoulder girdle muscle weakness (HP:0003547)2.39202270
48Pelvic girdle muscle weakness (HP:0003749)2.37715984
49Cerebral aneurysm (HP:0004944)2.35363525
50Abnormality of the distal phalanges of the toes (HP:0010182)2.35144163
51Natal tooth (HP:0000695)2.34247971
52Vascular tortuosity (HP:0004948)2.33189614
53Bowel diverticulosis (HP:0005222)2.32227389
54Protrusio acetabuli (HP:0003179)2.31918530
55Shallow orbits (HP:0000586)2.27917635
56Abnormality of the calcaneus (HP:0008364)2.24856015
57Back pain (HP:0003418)2.24184226
58Increased density of long bones (HP:0006392)2.23717143
59Elbow flexion contracture (HP:0002987)2.21605017
60Mildly elevated creatine phosphokinase (HP:0008180)2.20197313
61Cerebral inclusion bodies (HP:0100314)2.16703499
62Asymmetry of the thorax (HP:0001555)2.15559152
63Short 4th metacarpal (HP:0010044)2.15342228
64Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.15342228
65Abnormality of dentin (HP:0010299)2.14773162
66Cutaneous melanoma (HP:0012056)2.14570741
67Mitral regurgitation (HP:0001653)2.13547559
68Abnormality of the anterior horn cell (HP:0006802)2.13002703
69Degeneration of anterior horn cells (HP:0002398)2.13002703
70Centrally nucleated skeletal muscle fibers (HP:0003687)2.12897910
71Abnormal number of incisors (HP:0011064)2.08177052
72Neoplasm of the oral cavity (HP:0100649)2.07974494
73Gastrointestinal carcinoma (HP:0002672)2.06733374
74Malignant gastrointestinal tract tumors (HP:0006749)2.06733374
75Abnormality of the musculature of the pelvis (HP:0001469)2.02459121
76Abnormality of the hip-girdle musculature (HP:0001445)2.02459121
77Termporal pattern (HP:0011008)2.02065010
78Insidious onset (HP:0003587)2.02065010
79Resting tremor (HP:0002322)2.01195954
80Biliary tract neoplasm (HP:0100574)2.01014928
81Congenital stationary night blindness (HP:0007642)2.00010861
82Nuclear cataract (HP:0100018)1.98247909
83Esophageal atresia (HP:0002032)1.97964368
84Rhabdomyosarcoma (HP:0002859)1.97421601
85Generalized amyotrophy (HP:0003700)1.97237699
86Flat acetabular roof (HP:0003180)1.96657887
87High pitched voice (HP:0001620)1.94176009
88Wrist flexion contracture (HP:0001239)1.93660968
89Short humerus (HP:0005792)1.93074731
90Basal cell carcinoma (HP:0002671)1.92898668
91Aplasia/hypoplasia of the humerus (HP:0006507)1.92591920
92Fibroma (HP:0010614)1.92525836
93Aortic dissection (HP:0002647)1.91612436
94Blue sclerae (HP:0000592)1.90379855
95Freckling (HP:0001480)1.89934075
96Advanced eruption of teeth (HP:0006288)1.89933420
97Neoplasm of the pancreas (HP:0002894)1.87087182
98Abnormality of the umbilical cord (HP:0010881)1.85749617
99Fibrous tissue neoplasm (HP:0012316)1.85017140
100Neoplasm of striated muscle (HP:0009728)1.84398031
101Neurofibrillary tangles (HP:0002185)1.82677318
102Disproportionate tall stature (HP:0001519)1.82581277
103Reduced subcutaneous adipose tissue (HP:0003758)1.82374077
104Entropion (HP:0000621)1.80655321
105Abnormality of skeletal muscle fiber size (HP:0012084)1.80033090
106Elfin facies (HP:0004428)1.78578791
107Broad thumb (HP:0011304)1.78288123
108Increased variability in muscle fiber diameter (HP:0003557)1.77807254
109Dysmetric saccades (HP:0000641)1.77610636
110Spinal cord compression (HP:0002176)1.77102533
111Bladder diverticulum (HP:0000015)1.76840482
112Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.76822958
113Ankle contracture (HP:0006466)1.75220972
114Intestinal polyp (HP:0005266)1.74456052
115Cafe-au-lait spot (HP:0000957)1.74301121
116Dilatation of the ascending aorta (HP:0005111)1.73668823
117Trigonocephaly (HP:0000243)1.72649245
118Skull defect (HP:0001362)1.72522703
119Hypopigmentation of the fundus (HP:0007894)1.72458387
120Birth length less than 3rd percentile (HP:0003561)1.71859502
121Intestinal polyposis (HP:0200008)1.71158906
122Breech presentation (HP:0001623)1.70951094
123Insomnia (HP:0100785)1.70861630
124Radial bowing (HP:0002986)1.70217611
125Pterygium (HP:0001059)1.69892503
126Biconcave vertebral bodies (HP:0004586)1.69530978
127Ovarian neoplasm (HP:0100615)1.69426182
128Flat cornea (HP:0007720)1.68844672
129Patellar dislocation (HP:0002999)1.68590097
130Abnormal ossification of hand bones (HP:0005921)1.67773178
131Vertebral arch anomaly (HP:0008438)1.66364483
132Bowed forearm bones (HP:0003956)1.65758806
133Bowing of the arm (HP:0006488)1.65758806
134Abnormality of the acetabulum (HP:0003170)1.65590163
135Uterine neoplasm (HP:0010784)1.65540748
136Genu recurvatum (HP:0002816)1.63815208
137Patellar aplasia (HP:0006443)1.63813170
138Pseudobulbar signs (HP:0002200)1.63609644
139Nail dystrophy (HP:0008404)1.63592745
140Trismus (HP:0000211)1.63545029
141Absent radius (HP:0003974)1.62850034
142Broad phalanges of the hand (HP:0009768)1.62490789
143Ridged nail (HP:0001807)1.61916868
144Atrophy/Degeneration involving motor neurons (HP:0007373)1.61202337
145Syringomyelia (HP:0003396)1.60933605
146Spinal cord lesions (HP:0100561)1.60933605
147Renovascular hypertension (HP:0100817)1.60841212
148Abnormality of the distal phalanx of the thumb (HP:0009617)1.60370851
149Slender long bone (HP:0003100)1.60328391
150Orthostatic hypotension (HP:0001278)1.60176466
151Skin tags (HP:0010609)1.59910018
152Difficulty climbing stairs (HP:0003551)1.59498692
153Absent frontal sinuses (HP:0002688)1.59347565
154Metaphyseal cupping (HP:0003021)1.59133718
155Abnormality of oral frenula (HP:0000190)1.59007617
156Limb-girdle muscle atrophy (HP:0003797)1.58755016
157Mitral valve prolapse (HP:0001634)1.58744609
158Type 1 muscle fiber predominance (HP:0003803)1.58414133
159Overriding aorta (HP:0002623)1.58034119
160Preauricular skin tag (HP:0000384)1.58008409
161Milia (HP:0001056)1.57525118
162Upper limb muscle weakness (HP:0003484)1.57370995
163Megalocornea (HP:0000485)1.57063498
164Cervical subluxation (HP:0003308)1.56996370
165Ankyloglossia (HP:0010296)1.56465472
166Spinal muscular atrophy (HP:0007269)1.56398468
167Upper motor neuron abnormality (HP:0002127)1.56186581
168Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.55804499
169Vertebral hypoplasia (HP:0008417)1.55804499
170Broad distal phalanx of finger (HP:0009836)1.55521743
171Hyperparathyroidism (HP:0000843)1.53958985
172Arnold-Chiari malformation (HP:0002308)1.53783818
173Hammertoe (HP:0001765)1.53295509

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NEK14.05160838
2PKN23.90695540
3EEF2K3.82336157
4CDC73.35298860
5TSSK63.22622169
6IRAK33.05563126
7SMG12.92490360
8MST1R2.85834577
9BUB12.74560628
10PASK2.63465213
11NME22.50765715
12TRIB32.46831789
13NEK22.35143469
14CDK122.28342592
15TTN2.23447613
16SIK12.12823236
17WEE12.08700350
18EPHA22.02986708
19SCYL21.98806420
20TESK21.97957644
21NTRK11.96338281
22ARAF1.94450721
23PRPF4B1.93885810
24RPS6KB21.91470695
25PAK41.81725729
26ALK1.71933155
27LATS21.70059143
28TTK1.68374774
29MOS1.66321865
30TESK11.65312323
31LMTK21.60324022
32MAP3K101.57879716
33ERN11.57450238
34MAP3K81.47643876
35ERBB41.40378821
36FLT31.39633931
37TGFBR11.35155868
38FGFR11.34912208
39PLK31.32873538
40PLK11.26394339
41KSR21.26361283
42ATR1.22463033
43MAP3K131.19870751
44FGFR41.18220843
45MAP3K91.14778325
46RIPK11.14382288
47PDGFRA1.11623855
48CHEK11.11022200
49PAK61.10783797
50LIMK11.06053784
51LRRK21.05689218
52BMX1.05679036
53AURKB1.04258390
54KSR11.03278776
55CDK70.99392525
56STK100.97965756
57CDK40.97914193
58PRKD30.96807454
59EPHB10.96702136
60BRD40.95249849
61MTOR0.94747463
62PTK60.93027447
63CDK80.90894244
64EPHB20.89247911
65AURKA0.88790955
66BRAF0.87162614
67RPS6KA40.85598286
68BRSK10.85140516
69PAK20.83340008
70SIK30.78920368
71NEK90.78639357
72CDK20.78481559
73PAK10.77306369
74MKNK10.75078695
75EIF2AK10.73269067
76PIM20.71901272
77AKT20.70890101
78CHEK20.68656399
79CDK150.67723269
80SRPK10.67582444
81CDK180.65144464
82CDK60.63295511
83CDK140.62607632
84ATM0.61888760
85MAPKAPK30.61712480
86MAPK110.61710961
87CDK11A0.61343424
88ICK0.59506927
89BRSK20.57980170
90FER0.57794519
91CDK10.57479728
92PTK20.56485780
93PDK30.56422038
94PDK40.56422038
95TAOK20.56051790
96PBK0.56014141
97DAPK10.53297799
98STK38L0.53027804
99CDK90.52072630
100CAMKK10.51722983
101MINK10.51153289
102ILK0.49834228
103CSNK1E0.49121851
104RPS6KA20.48817554
105DDR20.48441413
106MAP3K30.48424608
107VRK20.46255174
108PNCK0.43828698
109MAP3K140.43331696
110DAPK30.43166789
111PRKDC0.42975726
112MAP2K30.42341548
113CDC42BPA0.42245503
114CAMK1D0.41868205
115MELK0.41244694
116PDPK10.40716842
117CSNK1D0.39975361
118MET0.39714234
119IRAK20.37650623
120CAMK2G0.37579655
121LATS10.37555081
122PDGFRB0.36770997
123TLK10.36413996
124RET0.36103670
125ROCK20.34523945
126PRKCI0.32697572
127CSNK2A20.30797203
128TYRO30.30224281
129STK380.29588237
130RAF10.29536681
131STK40.28989670
132MAPK140.28712188
133AKT10.26069688

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.35884919
2Mismatch repair_Homo sapiens_hsa034303.02032693
3Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.96483886
4RNA transport_Homo sapiens_hsa030132.66131264
5Spliceosome_Homo sapiens_hsa030402.50276839
6One carbon pool by folate_Homo sapiens_hsa006702.41442771
7Cell cycle_Homo sapiens_hsa041102.31288064
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.29542352
9Base excision repair_Homo sapiens_hsa034101.89939871
10Nucleotide excision repair_Homo sapiens_hsa034201.77157354
11mRNA surveillance pathway_Homo sapiens_hsa030151.71839802
12* Central carbon metabolism in cancer_Homo sapiens_hsa052301.65543463
13ECM-receptor interaction_Homo sapiens_hsa045121.59424709
14* Biosynthesis of amino acids_Homo sapiens_hsa012301.57454743
15* Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.50535143
16HIF-1 signaling pathway_Homo sapiens_hsa040661.48752944
17Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.45130894
18Oocyte meiosis_Homo sapiens_hsa041141.40986700
19Other glycan degradation_Homo sapiens_hsa005111.40600732
20Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.37732315
21Prion diseases_Homo sapiens_hsa050201.33950014
22RNA degradation_Homo sapiens_hsa030181.29386052
23Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.27085211
24Homologous recombination_Homo sapiens_hsa034401.26306797
252-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.25372420
26Hippo signaling pathway_Homo sapiens_hsa043901.25224929
27mTOR signaling pathway_Homo sapiens_hsa041501.24850601
28* Viral carcinogenesis_Homo sapiens_hsa052031.23395367
29p53 signaling pathway_Homo sapiens_hsa041151.22743859
30Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.18911996
31MicroRNAs in cancer_Homo sapiens_hsa052061.18702399
32Bladder cancer_Homo sapiens_hsa052191.15914195
33Colorectal cancer_Homo sapiens_hsa052101.13495517
34Chronic myeloid leukemia_Homo sapiens_hsa052201.10899348
35Fructose and mannose metabolism_Homo sapiens_hsa000511.08793175
36N-Glycan biosynthesis_Homo sapiens_hsa005101.07020393
37Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.06715404
38HTLV-I infection_Homo sapiens_hsa051661.05727945
39Proteasome_Homo sapiens_hsa030501.04016551
40Basal cell carcinoma_Homo sapiens_hsa052171.03275063
41Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.03108859
42Proteoglycans in cancer_Homo sapiens_hsa052051.01100266
43ErbB signaling pathway_Homo sapiens_hsa040120.99363322
44Synaptic vesicle cycle_Homo sapiens_hsa047210.98766757
45Adherens junction_Homo sapiens_hsa045200.98564964
46Amoebiasis_Homo sapiens_hsa051460.97911548
47Systemic lupus erythematosus_Homo sapiens_hsa053220.97302671
48Glycosaminoglycan degradation_Homo sapiens_hsa005310.97127873
49Vitamin B6 metabolism_Homo sapiens_hsa007500.95964539
50Alcoholism_Homo sapiens_hsa050340.95097792
51Epstein-Barr virus infection_Homo sapiens_hsa051690.94727291
52Non-homologous end-joining_Homo sapiens_hsa034500.94673197
53Fanconi anemia pathway_Homo sapiens_hsa034600.94497448
54Thyroid cancer_Homo sapiens_hsa052160.93623087
55Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.93079100
56Salmonella infection_Homo sapiens_hsa051320.91548678
57RNA polymerase_Homo sapiens_hsa030200.90778426
58* Carbon metabolism_Homo sapiens_hsa012000.89663381
59Small cell lung cancer_Homo sapiens_hsa052220.89512996
60Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.88647849
61Thyroid hormone signaling pathway_Homo sapiens_hsa049190.88070584
62Glioma_Homo sapiens_hsa052140.83816156
63Pentose phosphate pathway_Homo sapiens_hsa000300.83180978
64Endometrial cancer_Homo sapiens_hsa052130.82934888
65Tight junction_Homo sapiens_hsa045300.82743496
66Prostate cancer_Homo sapiens_hsa052150.81369208
67Notch signaling pathway_Homo sapiens_hsa043300.80156434
68Endocytosis_Homo sapiens_hsa041440.78691698
69Galactose metabolism_Homo sapiens_hsa000520.78026101
70Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.77903400
71Hedgehog signaling pathway_Homo sapiens_hsa043400.77365908
72Neurotrophin signaling pathway_Homo sapiens_hsa047220.76543363
73Non-small cell lung cancer_Homo sapiens_hsa052230.76297590
74Melanoma_Homo sapiens_hsa052180.76030081
75Focal adhesion_Homo sapiens_hsa045100.75304767
76Lysosome_Homo sapiens_hsa041420.75249392
77Pyrimidine metabolism_Homo sapiens_hsa002400.73244426
78Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.72590427
79Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.72330541
80Dilated cardiomyopathy_Homo sapiens_hsa054140.69457232
81Legionellosis_Homo sapiens_hsa051340.69112484
82Viral myocarditis_Homo sapiens_hsa054160.68738047
83TGF-beta signaling pathway_Homo sapiens_hsa043500.68147457
84Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.66868692
85Renal cell carcinoma_Homo sapiens_hsa052110.66025653
86Shigellosis_Homo sapiens_hsa051310.63509506
87Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.62476838
88Pathways in cancer_Homo sapiens_hsa052000.62459182
89Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.62410777
90Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.61481479
91Gap junction_Homo sapiens_hsa045400.61277821
92Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.60760753
93Antigen processing and presentation_Homo sapiens_hsa046120.60381979
94AMPK signaling pathway_Homo sapiens_hsa041520.60356115
95Estrogen signaling pathway_Homo sapiens_hsa049150.59588307
96Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.59413659
97VEGF signaling pathway_Homo sapiens_hsa043700.59009862
98Apoptosis_Homo sapiens_hsa042100.58318116
99Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.56268516
100Ribosome_Homo sapiens_hsa030100.55706611
101GnRH signaling pathway_Homo sapiens_hsa049120.54190509
102Cyanoamino acid metabolism_Homo sapiens_hsa004600.53941991
103Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.53569348
104Pancreatic cancer_Homo sapiens_hsa052120.53200911
105Axon guidance_Homo sapiens_hsa043600.52145010
106Vibrio cholerae infection_Homo sapiens_hsa051100.51210614
107Regulation of actin cytoskeleton_Homo sapiens_hsa048100.51176930
108Hepatitis C_Homo sapiens_hsa051600.50140450
109Sphingolipid signaling pathway_Homo sapiens_hsa040710.49633587
110Wnt signaling pathway_Homo sapiens_hsa043100.48300006
111Phototransduction_Homo sapiens_hsa047440.47712281
112Inositol phosphate metabolism_Homo sapiens_hsa005620.47387648
113Longevity regulating pathway - mammal_Homo sapiens_hsa042110.47377878
114AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.45902460
115Insulin signaling pathway_Homo sapiens_hsa049100.45740772
116Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.44865565
117Leukocyte transendothelial migration_Homo sapiens_hsa046700.44738159
118Long-term potentiation_Homo sapiens_hsa047200.44551200
119Cysteine and methionine metabolism_Homo sapiens_hsa002700.44511568
120Hepatitis B_Homo sapiens_hsa051610.44328438
121Phospholipase D signaling pathway_Homo sapiens_hsa040720.44275104
122Rap1 signaling pathway_Homo sapiens_hsa040150.43844720
123Lysine degradation_Homo sapiens_hsa003100.43462794
124Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.42755418
125Melanogenesis_Homo sapiens_hsa049160.41885309
126Acute myeloid leukemia_Homo sapiens_hsa052210.41671293
127* Glucagon signaling pathway_Homo sapiens_hsa049220.40375973
128PI3K-Akt signaling pathway_Homo sapiens_hsa041510.39621925

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »