

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | proteasome assembly (GO:0043248) | 5.97807654 |
| 2 | regulation of cellular amino acid metabolic process (GO:0006521) | 5.19901668 |
| 3 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 4.94892129 |
| 4 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 4.84983887 |
| 5 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 4.78381191 |
| 6 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 4.72334906 |
| 7 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 4.72334906 |
| 8 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 4.68250302 |
| 9 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 4.68250302 |
| 10 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 4.67464932 |
| 11 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 4.67464932 |
| 12 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 4.67464932 |
| 13 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 4.58644891 |
| 14 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 4.49387600 |
| 15 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 4.43001739 |
| 16 | negative regulation of ligase activity (GO:0051352) | 4.43001739 |
| 17 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 4.35809224 |
| 18 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO: | 4.34222775 |
| 19 | antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590) | 4.22042729 |
| 20 | negative regulation of B cell apoptotic process (GO:0002903) | 4.22026350 |
| 21 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 4.10857366 |
| 22 | positive regulation of ligase activity (GO:0051351) | 3.90875736 |
| 23 | positive regulation of cell cycle arrest (GO:0071158) | 3.80408529 |
| 24 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 3.78070438 |
| 25 | NADH dehydrogenase complex assembly (GO:0010257) | 3.78070438 |
| 26 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 3.78070438 |
| 27 | regulation of cellular amine metabolic process (GO:0033238) | 3.77523485 |
| 28 | histone H2A acetylation (GO:0043968) | 3.76720910 |
| 29 | protein maturation by protein folding (GO:0022417) | 3.75071621 |
| 30 | DNA damage response, signal transduction by p53 class mediator (GO:0030330) | 3.71183776 |
| 31 | sequestering of actin monomers (GO:0042989) | 3.66794980 |
| 32 | DNA deamination (GO:0045006) | 3.65309479 |
| 33 | protein neddylation (GO:0045116) | 3.56905318 |
| 34 | establishment of integrated proviral latency (GO:0075713) | 3.56814537 |
| 35 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 3.54420952 |
| 36 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 3.54420952 |
| 37 | positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523) | 3.49836533 |
| 38 | antigen processing and presentation of peptide antigen via MHC class I (GO:0002474) | 3.48821677 |
| 39 | cullin deneddylation (GO:0010388) | 3.44084405 |
| 40 | regulation of ubiquitin-protein transferase activity (GO:0051438) | 3.43325832 |
| 41 | protein complex biogenesis (GO:0070271) | 3.42214976 |
| 42 | rRNA modification (GO:0000154) | 3.40996746 |
| 43 | spliceosomal snRNP assembly (GO:0000387) | 3.40174408 |
| 44 | GTP biosynthetic process (GO:0006183) | 3.38950327 |
| 45 | protein deneddylation (GO:0000338) | 3.36427804 |
| 46 | mitochondrial respiratory chain complex assembly (GO:0033108) | 3.35315876 |
| 47 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 3.34128089 |
| 48 | chaperone-mediated protein transport (GO:0072321) | 3.33930288 |
| 49 | ribosome assembly (GO:0042255) | 3.33714901 |
| 50 | L-methionine salvage (GO:0071267) | 3.32570459 |
| 51 | L-methionine biosynthetic process (GO:0071265) | 3.32570459 |
| 52 | amino acid salvage (GO:0043102) | 3.32570459 |
| 53 | positive regulation of prostaglandin secretion (GO:0032308) | 3.32193876 |
| 54 | regulation of ligase activity (GO:0051340) | 3.29487788 |
| 55 | regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522) | 3.29130907 |
| 56 | UTP metabolic process (GO:0046051) | 3.27937104 |
| 57 | rRNA methylation (GO:0031167) | 3.25913773 |
| 58 | negative regulation of thymocyte apoptotic process (GO:0070244) | 3.25369862 |
| 59 | regulation of immune response to tumor cell (GO:0002837) | 3.24890599 |
| 60 | regulation of response to tumor cell (GO:0002834) | 3.24890599 |
| 61 | positive regulation of response to tumor cell (GO:0002836) | 3.24890599 |
| 62 | positive regulation of immune response to tumor cell (GO:0002839) | 3.24890599 |
| 63 | L-methionine biosynthetic process from methylthioadenosine (GO:0019509) | 3.20959392 |
| 64 | cellular response to zinc ion (GO:0071294) | 3.20429428 |
| 65 | signal transduction in response to DNA damage (GO:0042770) | 3.19059630 |
| 66 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 3.18480694 |
| 67 | ATP synthesis coupled proton transport (GO:0015986) | 3.18480694 |
| 68 | regulation of cell cycle arrest (GO:0071156) | 3.15675891 |
| 69 | establishment of viral latency (GO:0019043) | 3.11862418 |
| 70 | pyrimidine nucleoside triphosphate metabolic process (GO:0009147) | 3.11107084 |
| 71 | pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148) | 3.08400280 |
| 72 | regulation of translational termination (GO:0006449) | 3.05028867 |
| 73 | CTP metabolic process (GO:0046036) | 3.04643344 |
| 74 | CTP biosynthetic process (GO:0006241) | 3.04643344 |
| 75 | negative regulation of cell cycle G1/S phase transition (GO:1902807) | 3.03150079 |
| 76 | negative regulation of G1/S transition of mitotic cell cycle (GO:2000134) | 3.03150079 |
| 77 | pseudouridine synthesis (GO:0001522) | 3.01876642 |
| 78 | UTP biosynthetic process (GO:0006228) | 3.00291990 |
| 79 | pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208) | 3.00139599 |
| 80 | negative regulation of protein ubiquitination (GO:0031397) | 2.98627974 |
| 81 | negative regulation of JAK-STAT cascade (GO:0046426) | 2.96775061 |
| 82 | response to gravity (GO:0009629) | 2.96071940 |
| 83 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 2.95759376 |
| 84 | positive regulation of mitochondrial calcium ion concentration (GO:0051561) | 2.93721405 |
| 85 | guanosine-containing compound biosynthetic process (GO:1901070) | 2.92816243 |
| 86 | cell wall macromolecule metabolic process (GO:0044036) | 2.92576529 |
| 87 | regulation of skeletal muscle contraction (GO:0014819) | 2.91060242 |
| 88 | AMP metabolic process (GO:0046033) | 2.90227103 |
| 89 | ribosome biogenesis (GO:0042254) | 2.88380217 |
| 90 | negative regulation of protein modification by small protein conjugation or removal (GO:1903321) | 2.85084597 |
| 91 | maturation of 5.8S rRNA (GO:0000460) | 2.83624631 |
| 92 | protein K6-linked ubiquitination (GO:0085020) | 2.82383011 |
| 93 | peptidyl-histidine modification (GO:0018202) | 2.81179714 |
| 94 | positive regulation of protein ubiquitination (GO:0031398) | 2.80888145 |
| 95 | negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471) | 2.78753348 |
| 96 | pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209) | 2.78629378 |
| 97 | regulation of prostaglandin secretion (GO:0032306) | 2.76742506 |
| 98 | peptidyl-arginine omega-N-methylation (GO:0035247) | 2.76255672 |
| 99 | phosphate ion transport (GO:0006817) | 2.74328977 |
| 100 | negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315) | 2.71975423 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 5.00230863 |
| 2 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 4.87718507 |
| 3 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 4.82316725 |
| 4 | GATA1_22025678_ChIP-Seq_K562_Human | 4.19516472 |
| 5 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 3.96438087 |
| 6 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 3.83329474 |
| 7 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 3.34294602 |
| 8 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 3.33245253 |
| 9 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 3.11094631 |
| 10 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 3.09443671 |
| 11 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 3.00657402 |
| 12 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 2.97024441 |
| 13 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 2.90193986 |
| 14 | ELK1_19687146_ChIP-ChIP_HELA_Human | 2.90132105 |
| 15 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 2.87429610 |
| 16 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 2.79200244 |
| 17 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.70419700 |
| 18 | VDR_22108803_ChIP-Seq_LS180_Human | 2.55775105 |
| 19 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.47909911 |
| 20 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 2.43493526 |
| 21 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 2.40085564 |
| 22 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 2.39064735 |
| 23 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 2.36095011 |
| 24 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 2.24469959 |
| 25 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 2.17747366 |
| 26 | FOXP3_21729870_ChIP-Seq_TREG_Human | 2.09108286 |
| 27 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 2.02736830 |
| 28 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 1.89416356 |
| 29 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.88949821 |
| 30 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 1.87301435 |
| 31 | DCP1A_22483619_ChIP-Seq_HELA_Human | 1.86308121 |
| 32 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.78520745 |
| 33 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.78296026 |
| 34 | ATF3_23680149_ChIP-Seq_GBM1-GSC_Human | 1.77866987 |
| 35 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.75913900 |
| 36 | HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse | 1.73875503 |
| 37 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.72458705 |
| 38 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.71714189 |
| 39 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 1.70725993 |
| 40 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.69794104 |
| 41 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 1.68177607 |
| 42 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 1.67672962 |
| 43 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.65333850 |
| 44 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.64190647 |
| 45 | PPARD_23208498_ChIP-Seq_MDA-MB-231_Human | 1.59713465 |
| 46 | E2F7_22180533_ChIP-Seq_HELA_Human | 1.54980329 |
| 47 | EGR1_23403033_ChIP-Seq_LIVER_Mouse | 1.53698028 |
| 48 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.50201753 |
| 49 | XRN2_22483619_ChIP-Seq_HELA_Human | 1.49973990 |
| 50 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 1.47824445 |
| 51 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 1.47508197 |
| 52 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.46174545 |
| 53 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.41281594 |
| 54 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.41180166 |
| 55 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 1.39155649 |
| 56 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.38670873 |
| 57 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.37524756 |
| 58 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 1.37307833 |
| 59 | STAT4_19710469_ChIP-ChIP_TH1__Mouse | 1.35880817 |
| 60 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 1.33053200 |
| 61 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 1.32002227 |
| 62 | CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 1.29768162 |
| 63 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.29716414 |
| 64 | CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse | 1.25645447 |
| 65 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.25236088 |
| 66 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 1.22020130 |
| 67 | DACH1_20351289_ChIP-Seq_MDA-MB-231_Human | 1.14290377 |
| 68 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.13101376 |
| 69 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.11617508 |
| 70 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.10325261 |
| 71 | IRF8_21731497_ChIP-ChIP_J774_Mouse | 1.10249347 |
| 72 | IKZF1_21737484_ChIP-ChIP_HCT116_Human | 1.10013039 |
| 73 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.08986283 |
| 74 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 1.06266175 |
| 75 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 1.02424351 |
| 76 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 0.97661178 |
| 77 | CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 0.96729847 |
| 78 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 0.94391765 |
| 79 | SOX17_20123909_ChIP-Seq_XEN_Mouse | 0.93466744 |
| 80 | FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.93032077 |
| 81 | AUTS2_25519132_ChIP-Seq_293T-REX_Human | 0.92755875 |
| 82 | IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 0.88665310 |
| 83 | ELF5_23300383_ChIP-Seq_T47D_Human | 0.88426269 |
| 84 | PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse | 0.86447193 |
| 85 | SOX2_16153702_ChIP-ChIP_HESCs_Human | 0.86417488 |
| 86 | NANOG_16153702_ChIP-ChIP_HESCs_Human | 0.83598259 |
| 87 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 0.83353760 |
| 88 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 0.82538732 |
| 89 | EWS_26573619_Chip-Seq_HEK293_Human | 0.80477355 |
| 90 | TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse | 0.80357802 |
| 91 | E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 0.77682732 |
| 92 | KDM5A_27292631_Chip-Seq_BREAST_Human | 0.76551941 |
| 93 | TFEB_21752829_ChIP-Seq_HELA_Human | 0.74905817 |
| 94 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 0.74726190 |
| 95 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 0.72013776 |
| 96 | NANOG_18358816_ChIP-ChIP_MESCs_Mouse | 0.71882907 |
| 97 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 0.71302759 |
| 98 | ERG_20517297_ChIP-Seq_VCAP_Human | 0.69753857 |
| 99 | NCOR_22424771_ChIP-Seq_293T_Human | 0.69197446 |
| 100 | AR_20517297_ChIP-Seq_VCAP_Human | 0.69157407 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0000372_irregular_coat_pigmentation | 3.74522545 |
| 2 | MP0002138_abnormal_hepatobiliary_system | 3.73297732 |
| 3 | MP0003806_abnormal_nucleotide_metabolis | 3.28637000 |
| 4 | MP0001835_abnormal_antigen_presentation | 2.80785025 |
| 5 | MP0001348_abnormal_lacrimal_gland | 2.76432323 |
| 6 | MP0003878_abnormal_ear_physiology | 2.59985611 |
| 7 | MP0005377_hearing/vestibular/ear_phenot | 2.59985611 |
| 8 | MP0005645_abnormal_hypothalamus_physiol | 2.43988166 |
| 9 | MP0006054_spinal_hemorrhage | 2.33053119 |
| 10 | MP0010094_abnormal_chromosome_stability | 2.28174567 |
| 11 | MP0000749_muscle_degeneration | 2.27567874 |
| 12 | MP0001853_heart_inflammation | 2.26248446 |
| 13 | MP0003786_premature_aging | 2.25713297 |
| 14 | MP0004957_abnormal_blastocyst_morpholog | 2.18358634 |
| 15 | MP0005083_abnormal_biliary_tract | 2.05735369 |
| 16 | MP0002102_abnormal_ear_morphology | 2.03800640 |
| 17 | MP0000685_abnormal_immune_system | 2.03435495 |
| 18 | MP0003693_abnormal_embryo_hatching | 1.97128675 |
| 19 | MP0002877_abnormal_melanocyte_morpholog | 1.91136748 |
| 20 | MP0005084_abnormal_gallbladder_morpholo | 1.87065908 |
| 21 | MP0004147_increased_porphyrin_level | 1.86325507 |
| 22 | MP0005165_increased_susceptibility_to | 1.85953268 |
| 23 | MP0009333_abnormal_splenocyte_physiolog | 1.85183041 |
| 24 | MP0003718_maternal_effect | 1.83394769 |
| 25 | MP0000747_muscle_weakness | 1.79245939 |
| 26 | MP0004510_myositis | 1.69697265 |
| 27 | MP0005464_abnormal_platelet_physiology | 1.66865706 |
| 28 | MP0002332_abnormal_exercise_endurance | 1.63697775 |
| 29 | MP0008058_abnormal_DNA_repair | 1.63697529 |
| 30 | MP0001529_abnormal_vocalization | 1.60134179 |
| 31 | MP0004145_abnormal_muscle_electrophysio | 1.60072723 |
| 32 | MP0002166_altered_tumor_susceptibility | 1.58690854 |
| 33 | MP0002006_tumorigenesis | 1.52311927 |
| 34 | MP0008775_abnormal_heart_ventricle | 1.52096987 |
| 35 | MP0002163_abnormal_gland_morphology | 1.51793315 |
| 36 | MP0003111_abnormal_nucleus_morphology | 1.50258292 |
| 37 | MP0000647_abnormal_sebaceous_gland | 1.46683771 |
| 38 | MP0003646_muscle_fatigue | 1.46665871 |
| 39 | MP0001849_ear_inflammation | 1.42321894 |
| 40 | MP0008872_abnormal_physiological_respon | 1.40100591 |
| 41 | MP0002736_abnormal_nociception_after | 1.38496022 |
| 42 | MP0008875_abnormal_xenobiotic_pharmacok | 1.37363252 |
| 43 | MP0006036_abnormal_mitochondrial_physio | 1.35872744 |
| 44 | MP0003077_abnormal_cell_cycle | 1.34696579 |
| 45 | MP0003186_abnormal_redox_activity | 1.24773834 |
| 46 | MP0005360_urolithiasis | 1.24307324 |
| 47 | MP0002148_abnormal_hypersensitivity_rea | 1.24127171 |
| 48 | MP0004885_abnormal_endolymph | 1.23807915 |
| 49 | MP0002282_abnormal_trachea_morphology | 1.21676732 |
| 50 | MP0000465_gastrointestinal_hemorrhage | 1.18603193 |
| 51 | MP0001905_abnormal_dopamine_level | 1.17979152 |
| 52 | MP0009765_abnormal_xenobiotic_induced | 1.16098414 |
| 53 | MP0009764_decreased_sensitivity_to | 1.15677625 |
| 54 | MP0005257_abnormal_intraocular_pressure | 1.14189010 |
| 55 | MP0000383_abnormal_hair_follicle | 1.12167243 |
| 56 | MP0004272_abnormal_basement_membrane | 1.10822151 |
| 57 | MP0000537_abnormal_urethra_morphology | 1.04274195 |
| 58 | MP0010678_abnormal_skin_adnexa | 1.03883904 |
| 59 | MP0010234_abnormal_vibrissa_follicle | 1.03090862 |
| 60 | MP0008932_abnormal_embryonic_tissue | 1.02796257 |
| 61 | MP0006072_abnormal_retinal_apoptosis | 1.02535088 |
| 62 | MP0006035_abnormal_mitochondrial_morpho | 0.98082250 |
| 63 | MP0003283_abnormal_digestive_organ | 0.97490002 |
| 64 | MP0000358_abnormal_cell_content/ | 0.97383450 |
| 65 | MP0001879_abnormal_lymphatic_vessel | 0.95527643 |
| 66 | MP0004019_abnormal_vitamin_homeostasis | 0.93561180 |
| 67 | MP0005330_cardiomyopathy | 0.93359836 |
| 68 | MP0004484_altered_response_of | 0.92410803 |
| 69 | MP0008007_abnormal_cellular_replicative | 0.90537308 |
| 70 | MP0005671_abnormal_response_to | 0.89405997 |
| 71 | MP0005379_endocrine/exocrine_gland_phen | 0.87801572 |
| 72 | MP0004215_abnormal_myocardial_fiber | 0.86939798 |
| 73 | MP0003045_fibrosis | 0.85879307 |
| 74 | MP0002089_abnormal_postnatal_growth/wei | 0.85066952 |
| 75 | MP0003959_abnormal_lean_body | 0.84619402 |
| 76 | MP0000343_altered_response_to | 0.81355180 |
| 77 | MP0001542_abnormal_bone_strength | 0.79340291 |
| 78 | MP0009785_altered_susceptibility_to | 0.78247678 |
| 79 | MP0002733_abnormal_thermal_nociception | 0.77690715 |
| 80 | MP0005187_abnormal_penis_morphology | 0.77424856 |
| 81 | MP0005387_immune_system_phenotype | 0.76449835 |
| 82 | MP0001790_abnormal_immune_system | 0.76449835 |
| 83 | MP0005253_abnormal_eye_physiology | 0.76433055 |
| 84 | MP0004036_abnormal_muscle_relaxation | 0.76245647 |
| 85 | MP0006276_abnormal_autonomic_nervous | 0.74821225 |
| 86 | MP0001800_abnormal_humoral_immune | 0.71487614 |
| 87 | MP0001968_abnormal_touch/_nociception | 0.71393917 |
| 88 | MP0001243_abnormal_dermal_layer | 0.71314949 |
| 89 | MP0005319_abnormal_enzyme/_coenzyme | 0.71146473 |
| 90 | MP0001661_extended_life_span | 0.67675375 |
| 91 | MP0005620_abnormal_muscle_contractility | 0.66604598 |
| 92 | MP0002837_dystrophic_cardiac_calcinosis | 0.66351834 |
| 93 | MP0008438_abnormal_cutaneous_collagen | 0.64911994 |
| 94 | MP0001346_abnormal_lacrimal_gland | 0.64591557 |
| 95 | MP0000313_abnormal_cell_death | 0.64273110 |
| 96 | MP0002452_abnormal_antigen_presenting | 0.63518737 |
| 97 | MP0001730_embryonic_growth_arrest | 0.63350177 |
| 98 | MP0000427_abnormal_hair_cycle | 0.62426103 |
| 99 | MP0005075_abnormal_melanosome_morpholog | 0.58872920 |
| 100 | MP0003315_abnormal_perineum_morphology | 0.58720181 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Generalized aminoaciduria (HP:0002909) | 4.88789758 |
| 2 | Oral leukoplakia (HP:0002745) | 4.44106488 |
| 3 | Acute necrotizing encephalopathy (HP:0006965) | 4.24537196 |
| 4 | Reduced subcutaneous adipose tissue (HP:0003758) | 4.00644665 |
| 5 | Hepatic necrosis (HP:0002605) | 3.94592254 |
| 6 | Mitochondrial inheritance (HP:0001427) | 3.91671648 |
| 7 | Hepatocellular necrosis (HP:0001404) | 3.78459946 |
| 8 | Abnormal mitochondria in muscle tissue (HP:0008316) | 3.77094758 |
| 9 | Progressive macrocephaly (HP:0004481) | 3.72285164 |
| 10 | Acute encephalopathy (HP:0006846) | 3.71885311 |
| 11 | Increased CSF lactate (HP:0002490) | 3.70930664 |
| 12 | 3-Methylglutaconic aciduria (HP:0003535) | 3.53586450 |
| 13 | Chronic hepatic failure (HP:0100626) | 3.51887610 |
| 14 | Elevated erythrocyte sedimentation rate (HP:0003565) | 3.36238571 |
| 15 | Rough bone trabeculation (HP:0100670) | 3.24629417 |
| 16 | Abnormality of the anterior horn cell (HP:0006802) | 3.03625205 |
| 17 | Degeneration of anterior horn cells (HP:0002398) | 3.03625205 |
| 18 | Abnormality of alanine metabolism (HP:0010916) | 3.03492457 |
| 19 | Hyperalaninemia (HP:0003348) | 3.03492457 |
| 20 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 3.03492457 |
| 21 | Increased serum lactate (HP:0002151) | 2.92421988 |
| 22 | Abnormality of glycolysis (HP:0004366) | 2.85423092 |
| 23 | Cerebral edema (HP:0002181) | 2.82200143 |
| 24 | Paralysis (HP:0003470) | 2.79326368 |
| 25 | Increased IgM level (HP:0003496) | 2.75606077 |
| 26 | Increased serum pyruvate (HP:0003542) | 2.73166522 |
| 27 | Delayed CNS myelination (HP:0002188) | 2.69074731 |
| 28 | Intrahepatic cholestasis (HP:0001406) | 2.60218297 |
| 29 | Pancreatic cysts (HP:0001737) | 2.59145956 |
| 30 | Abnormality of placental membranes (HP:0011409) | 2.57853169 |
| 31 | Amniotic constriction ring (HP:0009775) | 2.57853169 |
| 32 | Decreased central vision (HP:0007663) | 2.56787525 |
| 33 | Tongue fasciculations (HP:0001308) | 2.53348253 |
| 34 | True hermaphroditism (HP:0010459) | 2.53042206 |
| 35 | Renal Fanconi syndrome (HP:0001994) | 2.51540236 |
| 36 | Exercise intolerance (HP:0003546) | 2.48747904 |
| 37 | Chronic sinusitis (HP:0011109) | 2.45543112 |
| 38 | Pendular nystagmus (HP:0012043) | 2.44705588 |
| 39 | Optic disc pallor (HP:0000543) | 2.39534564 |
| 40 | Hypoplastic pelvis (HP:0008839) | 2.37406118 |
| 41 | Exertional dyspnea (HP:0002875) | 2.37175779 |
| 42 | Abnormality of methionine metabolism (HP:0010901) | 2.36957732 |
| 43 | Large eyes (HP:0001090) | 2.36284457 |
| 44 | Conjunctival hamartoma (HP:0100780) | 2.36062845 |
| 45 | Lactic acidosis (HP:0003128) | 2.34085424 |
| 46 | Increased hepatocellular lipid droplets (HP:0006565) | 2.34031901 |
| 47 | Neoplasm of the peripheral nervous system (HP:0100007) | 2.32334179 |
| 48 | Sparse eyelashes (HP:0000653) | 2.30003851 |
| 49 | Congenital stationary night blindness (HP:0007642) | 2.29722487 |
| 50 | Respiratory failure (HP:0002878) | 2.25274231 |
| 51 | Furrowed tongue (HP:0000221) | 2.24459989 |
| 52 | Congenital, generalized hypertrichosis (HP:0004540) | 2.23372194 |
| 53 | Abnormal trabecular bone morphology (HP:0100671) | 2.23337256 |
| 54 | Nausea (HP:0002018) | 2.22492270 |
| 55 | Hypoplasia of the uterus (HP:0000013) | 2.22141765 |
| 56 | Neuroendocrine neoplasm (HP:0100634) | 2.20054327 |
| 57 | Shoulder girdle muscle weakness (HP:0003547) | 2.18816532 |
| 58 | Lipid accumulation in hepatocytes (HP:0006561) | 2.15265060 |
| 59 | Pancreatic fibrosis (HP:0100732) | 2.13213154 |
| 60 | Abnormal gallbladder physiology (HP:0012438) | 2.10362150 |
| 61 | Cholecystitis (HP:0001082) | 2.10362150 |
| 62 | Upper limb muscle weakness (HP:0003484) | 2.10250934 |
| 63 | Adrenal hypoplasia (HP:0000835) | 2.08234587 |
| 64 | Aplasia/Hypoplasia of the tongue (HP:0010295) | 2.05633213 |
| 65 | Hepatosplenomegaly (HP:0001433) | 2.02792042 |
| 66 | Leukodystrophy (HP:0002415) | 2.01409962 |
| 67 | Stenosis of the external auditory canal (HP:0000402) | 2.01073464 |
| 68 | Limb-girdle muscle atrophy (HP:0003797) | 2.00661167 |
| 69 | Palpitations (HP:0001962) | 2.00446786 |
| 70 | Abnormality of urine glucose concentration (HP:0011016) | 2.00274767 |
| 71 | Glycosuria (HP:0003076) | 2.00274767 |
| 72 | Pelvic girdle muscle weakness (HP:0003749) | 1.99643872 |
| 73 | Muscle fibrillation (HP:0010546) | 1.99101170 |
| 74 | Sclerocornea (HP:0000647) | 1.97184154 |
| 75 | Chronic otitis media (HP:0000389) | 1.96595464 |
| 76 | Aplasia/hypoplasia of the uterus (HP:0008684) | 1.93032376 |
| 77 | Conical tooth (HP:0000698) | 1.92466262 |
| 78 | Nemaline bodies (HP:0003798) | 1.91929665 |
| 79 | Proximal tubulopathy (HP:0000114) | 1.87638758 |
| 80 | Menorrhagia (HP:0000132) | 1.86537207 |
| 81 | Methylmalonic aciduria (HP:0012120) | 1.85203105 |
| 82 | Lethargy (HP:0001254) | 1.84809134 |
| 83 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 1.81489139 |
| 84 | Toxemia of pregnancy (HP:0100603) | 1.80085627 |
| 85 | CNS demyelination (HP:0007305) | 1.79928674 |
| 86 | Melanoma (HP:0002861) | 1.79241414 |
| 87 | Short femoral neck (HP:0100864) | 1.78837954 |
| 88 | Abolished electroretinogram (ERG) (HP:0000550) | 1.78282612 |
| 89 | Hamartoma of the eye (HP:0010568) | 1.77673073 |
| 90 | Abnormality of the musculature of the pelvis (HP:0001469) | 1.77603875 |
| 91 | Abnormality of the hip-girdle musculature (HP:0001445) | 1.77603875 |
| 92 | Abnormal spermatogenesis (HP:0008669) | 1.73744574 |
| 93 | Poor speech (HP:0002465) | 1.72922851 |
| 94 | Respiratory difficulties (HP:0002880) | 1.72533184 |
| 95 | Abnormality of the preputium (HP:0100587) | 1.72298769 |
| 96 | Molar tooth sign on MRI (HP:0002419) | 1.71169037 |
| 97 | Abnormality of midbrain morphology (HP:0002418) | 1.71169037 |
| 98 | Blindness (HP:0000618) | 1.68348238 |
| 99 | Small hand (HP:0200055) | 1.68062057 |
| 100 | Erythema (HP:0010783) | 1.67715727 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | VRK2 | 4.89669855 |
| 2 | MST4 | 3.38592514 |
| 3 | EIF2AK3 | 3.19066558 |
| 4 | BUB1 | 3.11741885 |
| 5 | TLK1 | 2.92734144 |
| 6 | TRIM28 | 2.92294689 |
| 7 | NEK1 | 2.92162220 |
| 8 | NME2 | 2.50778838 |
| 9 | VRK1 | 2.50567761 |
| 10 | TAF1 | 2.22314941 |
| 11 | EIF2AK1 | 2.14913980 |
| 12 | ZAK | 2.06310760 |
| 13 | PBK | 1.96272382 |
| 14 | MAPKAPK3 | 1.84792103 |
| 15 | CDC7 | 1.82155279 |
| 16 | TSSK6 | 1.81410407 |
| 17 | PHKG2 | 1.77110334 |
| 18 | PHKG1 | 1.77110334 |
| 19 | CSNK1G3 | 1.73126435 |
| 20 | SRPK1 | 1.70541720 |
| 21 | PAK4 | 1.66617573 |
| 22 | DAPK1 | 1.63578277 |
| 23 | BCKDK | 1.63070945 |
| 24 | SIK3 | 1.62953817 |
| 25 | EPHA2 | 1.61554319 |
| 26 | SMG1 | 1.58958096 |
| 27 | PLK3 | 1.51030472 |
| 28 | TESK1 | 1.47761142 |
| 29 | NUAK1 | 1.41831662 |
| 30 | LMTK2 | 1.37500138 |
| 31 | CSNK1A1L | 1.34369775 |
| 32 | CSNK1G1 | 1.33173910 |
| 33 | MAP2K7 | 1.32786078 |
| 34 | EIF2AK2 | 1.32150424 |
| 35 | CSNK1G2 | 1.31718437 |
| 36 | LIMK1 | 1.29364582 |
| 37 | AURKA | 1.19394443 |
| 38 | ARAF | 1.17190378 |
| 39 | TESK2 | 1.15604671 |
| 40 | STK16 | 1.10780819 |
| 41 | PLK2 | 1.06711925 |
| 42 | BCR | 1.06472192 |
| 43 | MYLK | 1.04441467 |
| 44 | ERBB4 | 1.03051527 |
| 45 | ADRBK2 | 1.01452383 |
| 46 | IKBKB | 0.95913216 |
| 47 | STK4 | 0.94638554 |
| 48 | CDK9 | 0.93096545 |
| 49 | ABL2 | 0.91188570 |
| 50 | ILK | 0.89922069 |
| 51 | DAPK3 | 0.87971238 |
| 52 | PDK2 | 0.87461222 |
| 53 | BLK | 0.84158243 |
| 54 | GRK5 | 0.82626243 |
| 55 | CDK19 | 0.81470294 |
| 56 | FRK | 0.80969460 |
| 57 | MAP3K12 | 0.80802886 |
| 58 | PIM2 | 0.77700322 |
| 59 | MOS | 0.72035107 |
| 60 | PTK2B | 0.71592632 |
| 61 | FER | 0.68882737 |
| 62 | MAP3K4 | 0.67234335 |
| 63 | TXK | 0.64228804 |
| 64 | CHEK2 | 0.62126305 |
| 65 | RPS6KA5 | 0.62074040 |
| 66 | ATR | 0.61774583 |
| 67 | PLK1 | 0.59694081 |
| 68 | PAK1 | 0.59460729 |
| 69 | WEE1 | 0.59189372 |
| 70 | AURKB | 0.58407727 |
| 71 | BMPR1B | 0.56472787 |
| 72 | PLK4 | 0.56160276 |
| 73 | CCNB1 | 0.56009558 |
| 74 | GRK7 | 0.54866558 |
| 75 | TNIK | 0.50281707 |
| 76 | MARK3 | 0.49841676 |
| 77 | CDK7 | 0.49542174 |
| 78 | GRK1 | 0.47850497 |
| 79 | DYRK2 | 0.45162557 |
| 80 | NME1 | 0.44556811 |
| 81 | TGFBR2 | 0.44306136 |
| 82 | SCYL2 | 0.44210084 |
| 83 | IRAK3 | 0.43183768 |
| 84 | MAP4K2 | 0.42593031 |
| 85 | BMPR2 | 0.42424044 |
| 86 | STK10 | 0.41414750 |
| 87 | TAOK2 | 0.40072195 |
| 88 | MST1R | 0.36064512 |
| 89 | CSNK2A1 | 0.34592478 |
| 90 | ERBB3 | 0.34559771 |
| 91 | CDK12 | 0.33509137 |
| 92 | PRKCI | 0.31856979 |
| 93 | KDR | 0.30156787 |
| 94 | ADRBK1 | 0.30154443 |
| 95 | NEK9 | 0.28621881 |
| 96 | OBSCN | 0.26914988 |
| 97 | MAPKAPK5 | 0.25099892 |
| 98 | CDK8 | 0.24522937 |
| 99 | CHEK1 | 0.22312569 |
| 100 | TGFBR1 | 0.21255239 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Proteasome_Homo sapiens_hsa03050 | 7.09055333 |
| 2 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 3.00470589 |
| 3 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 2.75376426 |
| 4 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 2.57164343 |
| 5 | DNA replication_Homo sapiens_hsa03030 | 2.29698342 |
| 6 | Parkinsons disease_Homo sapiens_hsa05012 | 2.27939562 |
| 7 | Mismatch repair_Homo sapiens_hsa03430 | 2.22997377 |
| 8 | Sulfur metabolism_Homo sapiens_hsa00920 | 2.18628161 |
| 9 | Protein export_Homo sapiens_hsa03060 | 2.14811934 |
| 10 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 2.00453508 |
| 11 | Fatty acid elongation_Homo sapiens_hsa00062 | 1.80086990 |
| 12 | Nucleotide excision repair_Homo sapiens_hsa03420 | 1.75628118 |
| 13 | Spliceosome_Homo sapiens_hsa03040 | 1.74230188 |
| 14 | Asthma_Homo sapiens_hsa05310 | 1.72278579 |
| 15 | Huntingtons disease_Homo sapiens_hsa05016 | 1.69132897 |
| 16 | RNA polymerase_Homo sapiens_hsa03020 | 1.66011688 |
| 17 | One carbon pool by folate_Homo sapiens_hsa00670 | 1.64710259 |
| 18 | Alcoholism_Homo sapiens_hsa05034 | 1.62286167 |
| 19 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.62168226 |
| 20 | Alzheimers disease_Homo sapiens_hsa05010 | 1.59462711 |
| 21 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 1.59159208 |
| 22 | Glutathione metabolism_Homo sapiens_hsa00480 | 1.56057737 |
| 23 | Non-homologous end-joining_Homo sapiens_hsa03450 | 1.52372492 |
| 24 | Homologous recombination_Homo sapiens_hsa03440 | 1.52112713 |
| 25 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.51995464 |
| 26 | Base excision repair_Homo sapiens_hsa03410 | 1.50289233 |
| 27 | Ribosome_Homo sapiens_hsa03010 | 1.41649722 |
| 28 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 1.39291066 |
| 29 | RNA transport_Homo sapiens_hsa03013 | 1.36807259 |
| 30 | Allograft rejection_Homo sapiens_hsa05330 | 1.31427715 |
| 31 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 1.22436027 |
| 32 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 1.22171854 |
| 33 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 1.18861435 |
| 34 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 1.15656756 |
| 35 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 1.12379946 |
| 36 | Carbon metabolism_Homo sapiens_hsa01200 | 1.11067723 |
| 37 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 1.09914660 |
| 38 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 1.09409277 |
| 39 | Purine metabolism_Homo sapiens_hsa00230 | 1.07640671 |
| 40 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 1.07509247 |
| 41 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 1.05684401 |
| 42 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 1.01508774 |
| 43 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 1.00419632 |
| 44 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 0.97448000 |
| 45 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.96456810 |
| 46 | Basal transcription factors_Homo sapiens_hsa03022 | 0.96102691 |
| 47 | RNA degradation_Homo sapiens_hsa03018 | 0.94211081 |
| 48 | Sulfur relay system_Homo sapiens_hsa04122 | 0.91671457 |
| 49 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 0.88284993 |
| 50 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.87935261 |
| 51 | Propanoate metabolism_Homo sapiens_hsa00640 | 0.87346501 |
| 52 | Graft-versus-host disease_Homo sapiens_hsa05332 | 0.87058658 |
| 53 | Viral carcinogenesis_Homo sapiens_hsa05203 | 0.86006090 |
| 54 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.83906666 |
| 55 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.83234114 |
| 56 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.80973403 |
| 57 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.80525391 |
| 58 | Phototransduction_Homo sapiens_hsa04744 | 0.78591907 |
| 59 | Galactose metabolism_Homo sapiens_hsa00052 | 0.76512077 |
| 60 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 0.75594544 |
| 61 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.75472433 |
| 62 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.70424424 |
| 63 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 0.65530634 |
| 64 | Renin-angiotensin system_Homo sapiens_hsa04614 | 0.65521027 |
| 65 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.63832377 |
| 66 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.62558934 |
| 67 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.61526152 |
| 68 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.61065569 |
| 69 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.59993700 |
| 70 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.59334420 |
| 71 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.57085079 |
| 72 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.56608298 |
| 73 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.53932606 |
| 74 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.53852508 |
| 75 | Metabolic pathways_Homo sapiens_hsa01100 | 0.53323403 |
| 76 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.51623170 |
| 77 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.51429468 |
| 78 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 0.51203081 |
| 79 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.50739614 |
| 80 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.50015626 |
| 81 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 0.47586208 |
| 82 | Peroxisome_Homo sapiens_hsa04146 | 0.45294751 |
| 83 | Apoptosis_Homo sapiens_hsa04210 | 0.42664523 |
| 84 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.42131635 |
| 85 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.41717510 |
| 86 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.39897078 |
| 87 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.38746468 |
| 88 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.37450246 |
| 89 | Starch and sucrose metabolism_Homo sapiens_hsa00500 | 0.36954654 |
| 90 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.34962609 |
| 91 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.33674884 |
| 92 | Salivary secretion_Homo sapiens_hsa04970 | 0.33324450 |
| 93 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.32765944 |
| 94 | Cell cycle_Homo sapiens_hsa04110 | 0.31991649 |
| 95 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.31802764 |
| 96 | Mineral absorption_Homo sapiens_hsa04978 | 0.30305269 |
| 97 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.30278454 |
| 98 | Herpes simplex infection_Homo sapiens_hsa05168 | 0.29764301 |
| 99 | Primary immunodeficiency_Homo sapiens_hsa05340 | 0.29273780 |
| 100 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.28490349 |

