PKMP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proteasome assembly (GO:0043248)5.97807654
2regulation of cellular amino acid metabolic process (GO:0006521)5.19901668
3negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.94892129
4DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:004.84983887
5positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)4.78381191
6signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)4.72334906
7intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)4.72334906
8signal transduction involved in DNA damage checkpoint (GO:0072422)4.68250302
9signal transduction involved in DNA integrity checkpoint (GO:0072401)4.68250302
10signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)4.67464932
11signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)4.67464932
12signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)4.67464932
13signal transduction involved in cell cycle checkpoint (GO:0072395)4.58644891
14regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)4.49387600
15negative regulation of ubiquitin-protein transferase activity (GO:0051444)4.43001739
16negative regulation of ligase activity (GO:0051352)4.43001739
17anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:04.35809224
18antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:4.34222775
19antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)4.22042729
20negative regulation of B cell apoptotic process (GO:0002903)4.22026350
21positive regulation of ubiquitin-protein transferase activity (GO:0051443)4.10857366
22positive regulation of ligase activity (GO:0051351)3.90875736
23positive regulation of cell cycle arrest (GO:0071158)3.80408529
24mitochondrial respiratory chain complex I assembly (GO:0032981)3.78070438
25NADH dehydrogenase complex assembly (GO:0010257)3.78070438
26mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.78070438
27regulation of cellular amine metabolic process (GO:0033238)3.77523485
28histone H2A acetylation (GO:0043968)3.76720910
29protein maturation by protein folding (GO:0022417)3.75071621
30DNA damage response, signal transduction by p53 class mediator (GO:0030330)3.71183776
31sequestering of actin monomers (GO:0042989)3.66794980
32DNA deamination (GO:0045006)3.65309479
33protein neddylation (GO:0045116)3.56905318
34establishment of integrated proviral latency (GO:0075713)3.56814537
35tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.54420952
36RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.54420952
37positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)3.49836533
38antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)3.48821677
39cullin deneddylation (GO:0010388)3.44084405
40regulation of ubiquitin-protein transferase activity (GO:0051438)3.43325832
41protein complex biogenesis (GO:0070271)3.42214976
42rRNA modification (GO:0000154)3.40996746
43spliceosomal snRNP assembly (GO:0000387)3.40174408
44GTP biosynthetic process (GO:0006183)3.38950327
45protein deneddylation (GO:0000338)3.36427804
46mitochondrial respiratory chain complex assembly (GO:0033108)3.35315876
47establishment of protein localization to mitochondrial membrane (GO:0090151)3.34128089
48chaperone-mediated protein transport (GO:0072321)3.33930288
49ribosome assembly (GO:0042255)3.33714901
50L-methionine salvage (GO:0071267)3.32570459
51L-methionine biosynthetic process (GO:0071265)3.32570459
52amino acid salvage (GO:0043102)3.32570459
53positive regulation of prostaglandin secretion (GO:0032308)3.32193876
54regulation of ligase activity (GO:0051340)3.29487788
55regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)3.29130907
56UTP metabolic process (GO:0046051)3.27937104
57rRNA methylation (GO:0031167)3.25913773
58negative regulation of thymocyte apoptotic process (GO:0070244)3.25369862
59regulation of immune response to tumor cell (GO:0002837)3.24890599
60regulation of response to tumor cell (GO:0002834)3.24890599
61positive regulation of response to tumor cell (GO:0002836)3.24890599
62positive regulation of immune response to tumor cell (GO:0002839)3.24890599
63L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.20959392
64cellular response to zinc ion (GO:0071294)3.20429428
65signal transduction in response to DNA damage (GO:0042770)3.19059630
66energy coupled proton transport, down electrochemical gradient (GO:0015985)3.18480694
67ATP synthesis coupled proton transport (GO:0015986)3.18480694
68regulation of cell cycle arrest (GO:0071156)3.15675891
69establishment of viral latency (GO:0019043)3.11862418
70pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.11107084
71pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.08400280
72regulation of translational termination (GO:0006449)3.05028867
73CTP metabolic process (GO:0046036)3.04643344
74CTP biosynthetic process (GO:0006241)3.04643344
75negative regulation of cell cycle G1/S phase transition (GO:1902807)3.03150079
76negative regulation of G1/S transition of mitotic cell cycle (GO:2000134)3.03150079
77pseudouridine synthesis (GO:0001522)3.01876642
78UTP biosynthetic process (GO:0006228)3.00291990
79pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)3.00139599
80negative regulation of protein ubiquitination (GO:0031397)2.98627974
81negative regulation of JAK-STAT cascade (GO:0046426)2.96775061
82response to gravity (GO:0009629)2.96071940
83mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.95759376
84positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.93721405
85guanosine-containing compound biosynthetic process (GO:1901070)2.92816243
86cell wall macromolecule metabolic process (GO:0044036)2.92576529
87regulation of skeletal muscle contraction (GO:0014819)2.91060242
88AMP metabolic process (GO:0046033)2.90227103
89ribosome biogenesis (GO:0042254)2.88380217
90negative regulation of protein modification by small protein conjugation or removal (GO:1903321)2.85084597
91maturation of 5.8S rRNA (GO:0000460)2.83624631
92protein K6-linked ubiquitination (GO:0085020)2.82383011
93peptidyl-histidine modification (GO:0018202)2.81179714
94positive regulation of protein ubiquitination (GO:0031398)2.80888145
95negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.78753348
96pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.78629378
97regulation of prostaglandin secretion (GO:0032306)2.76742506
98peptidyl-arginine omega-N-methylation (GO:0035247)2.76255672
99phosphate ion transport (GO:0006817)2.74328977
100negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.71975423

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human5.00230863
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.87718507
3GABP_17652178_ChIP-ChIP_JURKAT_Human4.82316725
4GATA1_22025678_ChIP-Seq_K562_Human4.19516472
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.96438087
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.83329474
7ETS1_20019798_ChIP-Seq_JURKAT_Human3.34294602
8NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.33245253
9ELF1_17652178_ChIP-ChIP_JURKAT_Human3.11094631
10SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.09443671
11E2F4_17652178_ChIP-ChIP_JURKAT_Human3.00657402
12CREB1_15753290_ChIP-ChIP_HEK293T_Human2.97024441
13HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.90193986
14ELK1_19687146_ChIP-ChIP_HELA_Human2.90132105
15EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.87429610
16FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.79200244
17VDR_23849224_ChIP-Seq_CD4+_Human2.70419700
18VDR_22108803_ChIP-Seq_LS180_Human2.55775105
19CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.47909911
20HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.43493526
21MYC_18555785_ChIP-Seq_MESCs_Mouse2.40085564
22YY1_21170310_ChIP-Seq_MESCs_Mouse2.39064735
23SRF_21415370_ChIP-Seq_HL-1_Mouse2.36095011
24MYC_18358816_ChIP-ChIP_MESCs_Mouse2.24469959
25MYC_19030024_ChIP-ChIP_MESCs_Mouse2.17747366
26FOXP3_21729870_ChIP-Seq_TREG_Human2.09108286
27E2F1_18555785_ChIP-Seq_MESCs_Mouse2.02736830
28MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.89416356
29THAP11_20581084_ChIP-Seq_MESCs_Mouse1.88949821
30IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.87301435
31DCP1A_22483619_ChIP-Seq_HELA_Human1.86308121
32PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.78520745
33HOXB4_20404135_ChIP-ChIP_EML_Mouse1.78296026
34ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.77866987
35MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.75913900
36HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.73875503
37PADI4_21655091_ChIP-ChIP_MCF-7_Human1.72458705
38TTF2_22483619_ChIP-Seq_HELA_Human1.71714189
39FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.70725993
40ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.69794104
41NELFA_20434984_ChIP-Seq_ESCs_Mouse1.68177607
42STAT3_1855785_ChIP-Seq_MESCs_Mouse1.67672962
43GABP_19822575_ChIP-Seq_HepG2_Human1.65333850
44MYC_18940864_ChIP-ChIP_HL60_Human1.64190647
45PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.59713465
46E2F7_22180533_ChIP-Seq_HELA_Human1.54980329
47EGR1_23403033_ChIP-Seq_LIVER_Mouse1.53698028
48SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.50201753
49XRN2_22483619_ChIP-Seq_HELA_Human1.49973990
50CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.47824445
51MYC_19079543_ChIP-ChIP_MESCs_Mouse1.47508197
52FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.46174545
53FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.41281594
54POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.41180166
55CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.39155649
56CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.38670873
57MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.37524756
58NANOG_18555785_ChIP-Seq_MESCs_Mouse1.37307833
59STAT4_19710469_ChIP-ChIP_TH1__Mouse1.35880817
60SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.33053200
61ERG_20887958_ChIP-Seq_HPC-7_Mouse1.32002227
62CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.29768162
63YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.29716414
64CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.25645447
65ZNF274_21170338_ChIP-Seq_K562_Hela1.25236088
66BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.22020130
67DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.14290377
68TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.13101376
69CIITA_25753668_ChIP-Seq_RAJI_Human1.11617508
70PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.10325261
71IRF8_21731497_ChIP-ChIP_J774_Mouse1.10249347
72IKZF1_21737484_ChIP-ChIP_HCT116_Human1.10013039
73ELK1_22589737_ChIP-Seq_MCF10A_Human1.08986283
74CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.06266175
75HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.02424351
76FOXM1_23109430_ChIP-Seq_U2OS_Human0.97661178
77CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.96729847
78ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.94391765
79SOX17_20123909_ChIP-Seq_XEN_Mouse0.93466744
80FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93032077
81AUTS2_25519132_ChIP-Seq_293T-REX_Human0.92755875
82IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.88665310
83ELF5_23300383_ChIP-Seq_T47D_Human0.88426269
84PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.86447193
85SOX2_16153702_ChIP-ChIP_HESCs_Human0.86417488
86NANOG_16153702_ChIP-ChIP_HESCs_Human0.83598259
87DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.83353760
88MYCN_18555785_ChIP-Seq_MESCs_Mouse0.82538732
89EWS_26573619_Chip-Seq_HEK293_Human0.80477355
90TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.80357802
91E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.77682732
92KDM5A_27292631_Chip-Seq_BREAST_Human0.76551941
93TFEB_21752829_ChIP-Seq_HELA_Human0.74905817
94E2F1_21310950_ChIP-Seq_MCF-7_Human0.74726190
95EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.72013776
96NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.71882907
97IRF8_22096565_ChIP-ChIP_GC-B_Human0.71302759
98ERG_20517297_ChIP-Seq_VCAP_Human0.69753857
99NCOR_22424771_ChIP-Seq_293T_Human0.69197446
100AR_20517297_ChIP-Seq_VCAP_Human0.69157407

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000372_irregular_coat_pigmentation3.74522545
2MP0002138_abnormal_hepatobiliary_system3.73297732
3MP0003806_abnormal_nucleotide_metabolis3.28637000
4MP0001835_abnormal_antigen_presentation2.80785025
5MP0001348_abnormal_lacrimal_gland2.76432323
6MP0005377_hearing/vestibular/ear_phenot2.59985611
7MP0003878_abnormal_ear_physiology2.59985611
8MP0005645_abnormal_hypothalamus_physiol2.43988166
9MP0006054_spinal_hemorrhage2.33053119
10MP0010094_abnormal_chromosome_stability2.28174567
11MP0000749_muscle_degeneration2.27567874
12MP0001853_heart_inflammation2.26248446
13MP0003786_premature_aging2.25713297
14MP0004957_abnormal_blastocyst_morpholog2.18358634
15MP0005083_abnormal_biliary_tract2.05735369
16MP0002102_abnormal_ear_morphology2.03800640
17MP0000685_abnormal_immune_system2.03435495
18MP0003693_abnormal_embryo_hatching1.97128675
19MP0002877_abnormal_melanocyte_morpholog1.91136748
20MP0005084_abnormal_gallbladder_morpholo1.87065908
21MP0004147_increased_porphyrin_level1.86325507
22MP0005165_increased_susceptibility_to1.85953268
23MP0009333_abnormal_splenocyte_physiolog1.85183041
24MP0003718_maternal_effect1.83394769
25MP0000747_muscle_weakness1.79245939
26MP0004510_myositis1.69697265
27MP0005464_abnormal_platelet_physiology1.66865706
28MP0002332_abnormal_exercise_endurance1.63697775
29MP0008058_abnormal_DNA_repair1.63697529
30MP0001529_abnormal_vocalization1.60134179
31MP0004145_abnormal_muscle_electrophysio1.60072723
32MP0002166_altered_tumor_susceptibility1.58690854
33MP0002006_tumorigenesis1.52311927
34MP0008775_abnormal_heart_ventricle1.52096987
35MP0002163_abnormal_gland_morphology1.51793315
36MP0003111_abnormal_nucleus_morphology1.50258292
37MP0000647_abnormal_sebaceous_gland1.46683771
38MP0003646_muscle_fatigue1.46665871
39MP0001849_ear_inflammation1.42321894
40MP0008872_abnormal_physiological_respon1.40100591
41MP0002736_abnormal_nociception_after1.38496022
42MP0008875_abnormal_xenobiotic_pharmacok1.37363252
43MP0006036_abnormal_mitochondrial_physio1.35872744
44MP0003077_abnormal_cell_cycle1.34696579
45MP0003186_abnormal_redox_activity1.24773834
46MP0005360_urolithiasis1.24307324
47MP0002148_abnormal_hypersensitivity_rea1.24127171
48MP0004885_abnormal_endolymph1.23807915
49MP0002282_abnormal_trachea_morphology1.21676732
50MP0000465_gastrointestinal_hemorrhage1.18603193
51MP0001905_abnormal_dopamine_level1.17979152
52MP0009765_abnormal_xenobiotic_induced1.16098414
53MP0009764_decreased_sensitivity_to1.15677625
54MP0005257_abnormal_intraocular_pressure1.14189010
55MP0000383_abnormal_hair_follicle1.12167243
56MP0004272_abnormal_basement_membrane1.10822151
57MP0000537_abnormal_urethra_morphology1.04274195
58MP0010678_abnormal_skin_adnexa1.03883904
59MP0010234_abnormal_vibrissa_follicle1.03090862
60MP0008932_abnormal_embryonic_tissue1.02796257
61MP0006072_abnormal_retinal_apoptosis1.02535088
62MP0006035_abnormal_mitochondrial_morpho0.98082250
63MP0003283_abnormal_digestive_organ0.97490002
64MP0000358_abnormal_cell_content/0.97383450
65MP0001879_abnormal_lymphatic_vessel0.95527643
66MP0004019_abnormal_vitamin_homeostasis0.93561180
67MP0005330_cardiomyopathy0.93359836
68MP0004484_altered_response_of0.92410803
69MP0008007_abnormal_cellular_replicative0.90537308
70MP0005671_abnormal_response_to0.89405997
71MP0005379_endocrine/exocrine_gland_phen0.87801572
72MP0004215_abnormal_myocardial_fiber0.86939798
73MP0003045_fibrosis0.85879307
74MP0002089_abnormal_postnatal_growth/wei0.85066952
75MP0003959_abnormal_lean_body0.84619402
76MP0000343_altered_response_to0.81355180
77MP0001542_abnormal_bone_strength0.79340291
78MP0009785_altered_susceptibility_to0.78247678
79MP0002733_abnormal_thermal_nociception0.77690715
80MP0005187_abnormal_penis_morphology0.77424856
81MP0005387_immune_system_phenotype0.76449835
82MP0001790_abnormal_immune_system0.76449835
83MP0005253_abnormal_eye_physiology0.76433055
84MP0004036_abnormal_muscle_relaxation0.76245647
85MP0006276_abnormal_autonomic_nervous0.74821225
86MP0001800_abnormal_humoral_immune0.71487614
87MP0001968_abnormal_touch/_nociception0.71393917
88MP0001243_abnormal_dermal_layer0.71314949
89MP0005319_abnormal_enzyme/_coenzyme0.71146473
90MP0001661_extended_life_span0.67675375
91MP0005620_abnormal_muscle_contractility0.66604598
92MP0002837_dystrophic_cardiac_calcinosis0.66351834
93MP0008438_abnormal_cutaneous_collagen0.64911994
94MP0001346_abnormal_lacrimal_gland0.64591557
95MP0000313_abnormal_cell_death0.64273110
96MP0002452_abnormal_antigen_presenting0.63518737
97MP0001730_embryonic_growth_arrest0.63350177
98MP0000427_abnormal_hair_cycle0.62426103
99MP0005075_abnormal_melanosome_morpholog0.58872920
100MP0003315_abnormal_perineum_morphology0.58720181

Predicted human phenotypes

RankGene SetZ-score
1Generalized aminoaciduria (HP:0002909)4.88789758
2Oral leukoplakia (HP:0002745)4.44106488
3Acute necrotizing encephalopathy (HP:0006965)4.24537196
4Reduced subcutaneous adipose tissue (HP:0003758)4.00644665
5Hepatic necrosis (HP:0002605)3.94592254
6Mitochondrial inheritance (HP:0001427)3.91671648
7Hepatocellular necrosis (HP:0001404)3.78459946
8Abnormal mitochondria in muscle tissue (HP:0008316)3.77094758
9Progressive macrocephaly (HP:0004481)3.72285164
10Acute encephalopathy (HP:0006846)3.71885311
11Increased CSF lactate (HP:0002490)3.70930664
123-Methylglutaconic aciduria (HP:0003535)3.53586450
13Chronic hepatic failure (HP:0100626)3.51887610
14Elevated erythrocyte sedimentation rate (HP:0003565)3.36238571
15Rough bone trabeculation (HP:0100670)3.24629417
16Abnormality of the anterior horn cell (HP:0006802)3.03625205
17Degeneration of anterior horn cells (HP:0002398)3.03625205
18Abnormality of alanine metabolism (HP:0010916)3.03492457
19Hyperalaninemia (HP:0003348)3.03492457
20Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.03492457
21Increased serum lactate (HP:0002151)2.92421988
22Abnormality of glycolysis (HP:0004366)2.85423092
23Cerebral edema (HP:0002181)2.82200143
24Paralysis (HP:0003470)2.79326368
25Increased IgM level (HP:0003496)2.75606077
26Increased serum pyruvate (HP:0003542)2.73166522
27Delayed CNS myelination (HP:0002188)2.69074731
28Intrahepatic cholestasis (HP:0001406)2.60218297
29Pancreatic cysts (HP:0001737)2.59145956
30Abnormality of placental membranes (HP:0011409)2.57853169
31Amniotic constriction ring (HP:0009775)2.57853169
32Decreased central vision (HP:0007663)2.56787525
33Tongue fasciculations (HP:0001308)2.53348253
34True hermaphroditism (HP:0010459)2.53042206
35Renal Fanconi syndrome (HP:0001994)2.51540236
36Exercise intolerance (HP:0003546)2.48747904
37Chronic sinusitis (HP:0011109)2.45543112
38Pendular nystagmus (HP:0012043)2.44705588
39Optic disc pallor (HP:0000543)2.39534564
40Hypoplastic pelvis (HP:0008839)2.37406118
41Exertional dyspnea (HP:0002875)2.37175779
42Abnormality of methionine metabolism (HP:0010901)2.36957732
43Large eyes (HP:0001090)2.36284457
44Conjunctival hamartoma (HP:0100780)2.36062845
45Lactic acidosis (HP:0003128)2.34085424
46Increased hepatocellular lipid droplets (HP:0006565)2.34031901
47Neoplasm of the peripheral nervous system (HP:0100007)2.32334179
48Sparse eyelashes (HP:0000653)2.30003851
49Congenital stationary night blindness (HP:0007642)2.29722487
50Respiratory failure (HP:0002878)2.25274231
51Furrowed tongue (HP:0000221)2.24459989
52Congenital, generalized hypertrichosis (HP:0004540)2.23372194
53Abnormal trabecular bone morphology (HP:0100671)2.23337256
54Nausea (HP:0002018)2.22492270
55Hypoplasia of the uterus (HP:0000013)2.22141765
56Neuroendocrine neoplasm (HP:0100634)2.20054327
57Shoulder girdle muscle weakness (HP:0003547)2.18816532
58Lipid accumulation in hepatocytes (HP:0006561)2.15265060
59Pancreatic fibrosis (HP:0100732)2.13213154
60Cholecystitis (HP:0001082)2.10362150
61Abnormal gallbladder physiology (HP:0012438)2.10362150
62Upper limb muscle weakness (HP:0003484)2.10250934
63Adrenal hypoplasia (HP:0000835)2.08234587
64Aplasia/Hypoplasia of the tongue (HP:0010295)2.05633213
65Hepatosplenomegaly (HP:0001433)2.02792042
66Leukodystrophy (HP:0002415)2.01409962
67Stenosis of the external auditory canal (HP:0000402)2.01073464
68Limb-girdle muscle atrophy (HP:0003797)2.00661167
69Palpitations (HP:0001962)2.00446786
70Glycosuria (HP:0003076)2.00274767
71Abnormality of urine glucose concentration (HP:0011016)2.00274767
72Pelvic girdle muscle weakness (HP:0003749)1.99643872
73Muscle fibrillation (HP:0010546)1.99101170
74Sclerocornea (HP:0000647)1.97184154
75Chronic otitis media (HP:0000389)1.96595464
76Aplasia/hypoplasia of the uterus (HP:0008684)1.93032376
77Conical tooth (HP:0000698)1.92466262
78Nemaline bodies (HP:0003798)1.91929665
79Proximal tubulopathy (HP:0000114)1.87638758
80Menorrhagia (HP:0000132)1.86537207
81Methylmalonic aciduria (HP:0012120)1.85203105
82Lethargy (HP:0001254)1.84809134
83Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.81489139
84Toxemia of pregnancy (HP:0100603)1.80085627
85CNS demyelination (HP:0007305)1.79928674
86Melanoma (HP:0002861)1.79241414
87Short femoral neck (HP:0100864)1.78837954
88Abolished electroretinogram (ERG) (HP:0000550)1.78282612
89Hamartoma of the eye (HP:0010568)1.77673073
90Abnormality of the hip-girdle musculature (HP:0001445)1.77603875
91Abnormality of the musculature of the pelvis (HP:0001469)1.77603875
92Abnormal spermatogenesis (HP:0008669)1.73744574
93Poor speech (HP:0002465)1.72922851
94Respiratory difficulties (HP:0002880)1.72533184
95Abnormality of the preputium (HP:0100587)1.72298769
96Molar tooth sign on MRI (HP:0002419)1.71169037
97Abnormality of midbrain morphology (HP:0002418)1.71169037
98Blindness (HP:0000618)1.68348238
99Small hand (HP:0200055)1.68062057
100Erythema (HP:0010783)1.67715727

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK24.89669855
2MST43.38592514
3EIF2AK33.19066558
4BUB13.11741885
5TLK12.92734144
6TRIM282.92294689
7NEK12.92162220
8NME22.50778838
9VRK12.50567761
10TAF12.22314941
11EIF2AK12.14913980
12ZAK2.06310760
13PBK1.96272382
14MAPKAPK31.84792103
15CDC71.82155279
16TSSK61.81410407
17PHKG21.77110334
18PHKG11.77110334
19CSNK1G31.73126435
20SRPK11.70541720
21PAK41.66617573
22DAPK11.63578277
23BCKDK1.63070945
24SIK31.62953817
25EPHA21.61554319
26SMG11.58958096
27PLK31.51030472
28TESK11.47761142
29NUAK11.41831662
30LMTK21.37500138
31CSNK1A1L1.34369775
32CSNK1G11.33173910
33MAP2K71.32786078
34EIF2AK21.32150424
35CSNK1G21.31718437
36LIMK11.29364582
37AURKA1.19394443
38ARAF1.17190378
39TESK21.15604671
40STK161.10780819
41PLK21.06711925
42BCR1.06472192
43MYLK1.04441467
44ERBB41.03051527
45ADRBK21.01452383
46IKBKB0.95913216
47STK40.94638554
48CDK90.93096545
49ABL20.91188570
50ILK0.89922069
51DAPK30.87971238
52PDK20.87461222
53BLK0.84158243
54GRK50.82626243
55CDK190.81470294
56FRK0.80969460
57MAP3K120.80802886
58PIM20.77700322
59MOS0.72035107
60PTK2B0.71592632
61FER0.68882737
62MAP3K40.67234335
63TXK0.64228804
64CHEK20.62126305
65RPS6KA50.62074040
66ATR0.61774583
67PLK10.59694081
68PAK10.59460729
69WEE10.59189372
70AURKB0.58407727
71BMPR1B0.56472787
72PLK40.56160276
73CCNB10.56009558
74GRK70.54866558
75TNIK0.50281707
76MARK30.49841676
77CDK70.49542174
78GRK10.47850497
79DYRK20.45162557
80NME10.44556811
81TGFBR20.44306136
82SCYL20.44210084
83IRAK30.43183768
84MAP4K20.42593031
85BMPR20.42424044
86STK100.41414750
87TAOK20.40072195
88MST1R0.36064512
89CSNK2A10.34592478
90ERBB30.34559771
91CDK120.33509137
92PRKCI0.31856979
93KDR0.30156787
94ADRBK10.30154443
95NEK90.28621881
96OBSCN0.26914988
97MAPKAPK50.25099892
98CDK80.24522937
99CHEK10.22312569
100TGFBR10.21255239

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030507.09055333
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.00470589
3Systemic lupus erythematosus_Homo sapiens_hsa053222.75376426
4Oxidative phosphorylation_Homo sapiens_hsa001902.57164343
5DNA replication_Homo sapiens_hsa030302.29698342
6Parkinsons disease_Homo sapiens_hsa050122.27939562
7Mismatch repair_Homo sapiens_hsa034302.22997377
8Sulfur metabolism_Homo sapiens_hsa009202.18628161
9Protein export_Homo sapiens_hsa030602.14811934
10Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.00453508
11Fatty acid elongation_Homo sapiens_hsa000621.80086990
12Nucleotide excision repair_Homo sapiens_hsa034201.75628118
13Spliceosome_Homo sapiens_hsa030401.74230188
14Asthma_Homo sapiens_hsa053101.72278579
15Huntingtons disease_Homo sapiens_hsa050161.69132897
16RNA polymerase_Homo sapiens_hsa030201.66011688
17One carbon pool by folate_Homo sapiens_hsa006701.64710259
18Alcoholism_Homo sapiens_hsa050341.62286167
19Pyrimidine metabolism_Homo sapiens_hsa002401.62168226
20Alzheimers disease_Homo sapiens_hsa050101.59462711
21Primary bile acid biosynthesis_Homo sapiens_hsa001201.59159208
22Glutathione metabolism_Homo sapiens_hsa004801.56057737
23Non-homologous end-joining_Homo sapiens_hsa034501.52372492
24Homologous recombination_Homo sapiens_hsa034401.52112713
25Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.51995464
26Base excision repair_Homo sapiens_hsa034101.50289233
27Ribosome_Homo sapiens_hsa030101.41649722
28Cysteine and methionine metabolism_Homo sapiens_hsa002701.39291066
29RNA transport_Homo sapiens_hsa030131.36807259
30Allograft rejection_Homo sapiens_hsa053301.31427715
31Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.22436027
32Intestinal immune network for IgA production_Homo sapiens_hsa046721.22171854
33Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.18861435
34Biosynthesis of amino acids_Homo sapiens_hsa012301.15656756
35Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.12379946
36Carbon metabolism_Homo sapiens_hsa012001.11067723
37Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.09914660
38Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.09409277
39Purine metabolism_Homo sapiens_hsa002301.07640671
40Autoimmune thyroid disease_Homo sapiens_hsa053201.07509247
41Pentose phosphate pathway_Homo sapiens_hsa000301.05684401
42Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.01508774
43SNARE interactions in vesicular transport_Homo sapiens_hsa041301.00419632
44Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.97448000
45Selenocompound metabolism_Homo sapiens_hsa004500.96456810
46Basal transcription factors_Homo sapiens_hsa030220.96102691
47RNA degradation_Homo sapiens_hsa030180.94211081
48Sulfur relay system_Homo sapiens_hsa041220.91671457
49Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.88284993
50Nitrogen metabolism_Homo sapiens_hsa009100.87935261
51Propanoate metabolism_Homo sapiens_hsa006400.87346501
52Graft-versus-host disease_Homo sapiens_hsa053320.87058658
53Viral carcinogenesis_Homo sapiens_hsa052030.86006090
54Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.83906666
55Pyruvate metabolism_Homo sapiens_hsa006200.83234114
56Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.80973403
57Type I diabetes mellitus_Homo sapiens_hsa049400.80525391
58Phototransduction_Homo sapiens_hsa047440.78591907
59Galactose metabolism_Homo sapiens_hsa000520.76512077
60Fanconi anemia pathway_Homo sapiens_hsa034600.75594544
61Cyanoamino acid metabolism_Homo sapiens_hsa004600.75472433
62Collecting duct acid secretion_Homo sapiens_hsa049660.70424424
63Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.65530634
64Renin-angiotensin system_Homo sapiens_hsa046140.65521027
65Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.63832377
662-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.62558934
67Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.61526152
68Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.61065569
69Cardiac muscle contraction_Homo sapiens_hsa042600.59993700
70Antigen processing and presentation_Homo sapiens_hsa046120.59334420
71Epstein-Barr virus infection_Homo sapiens_hsa051690.57085079
72p53 signaling pathway_Homo sapiens_hsa041150.56608298
73Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.53932606
74Rheumatoid arthritis_Homo sapiens_hsa053230.53852508
75Metabolic pathways_Homo sapiens_hsa011000.53323403
76Regulation of autophagy_Homo sapiens_hsa041400.51623170
77Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.51429468
78NF-kappa B signaling pathway_Homo sapiens_hsa040640.51203081
79Tryptophan metabolism_Homo sapiens_hsa003800.50739614
80Pentose and glucuronate interconversions_Homo sapiens_hsa000400.50015626
81Transcriptional misregulation in cancer_Homo sapiens_hsa052020.47586208
82Peroxisome_Homo sapiens_hsa041460.45294751
83Apoptosis_Homo sapiens_hsa042100.42664523
84Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.42131635
85Drug metabolism - other enzymes_Homo sapiens_hsa009830.41717510
86Fructose and mannose metabolism_Homo sapiens_hsa000510.39897078
87Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.38746468
88N-Glycan biosynthesis_Homo sapiens_hsa005100.37450246
89Starch and sucrose metabolism_Homo sapiens_hsa005000.36954654
90Vibrio cholerae infection_Homo sapiens_hsa051100.34962609
91Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.33674884
92Salivary secretion_Homo sapiens_hsa049700.33324450
93Steroid hormone biosynthesis_Homo sapiens_hsa001400.32765944
94Cell cycle_Homo sapiens_hsa041100.31991649
95Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.31802764
96Mineral absorption_Homo sapiens_hsa049780.30305269
97Folate biosynthesis_Homo sapiens_hsa007900.30278454
98Herpes simplex infection_Homo sapiens_hsa051680.29764301
99Primary immunodeficiency_Homo sapiens_hsa053400.29273780
100Arginine and proline metabolism_Homo sapiens_hsa003300.28490349

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »