PKMP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)7.35435310
2RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)7.35435310
3homocysteine metabolic process (GO:0050667)6.57171630
4proteasome assembly (GO:0043248)6.53609020
5purine nucleotide salvage (GO:0032261)6.38045272
6regulation of plasminogen activation (GO:0010755)6.26045045
7folic acid-containing compound biosynthetic process (GO:0009396)6.19569157
8positive regulation of endothelial cell differentiation (GO:0045603)5.75920528
9adenosine metabolic process (GO:0046085)5.73395389
10sulfur amino acid catabolic process (GO:0000098)5.49725098
11galactose catabolic process (GO:0019388)5.15833228
12negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)4.89668211
13galactose metabolic process (GO:0006012)4.65479019
14cysteine metabolic process (GO:0006534)4.58195178
15microtubule nucleation (GO:0007020)4.55028984
16epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)4.45796636
17negative regulation of catenin import into nucleus (GO:0035414)4.34093452
18positive regulation of mitochondrial calcium ion concentration (GO:0051561)4.29632915
19platelet dense granule organization (GO:0060155)4.26707646
20alternative mRNA splicing, via spliceosome (GO:0000380)4.20597575
21white fat cell differentiation (GO:0050872)4.11722915
22regulation of endothelial cell differentiation (GO:0045601)4.11281212
23pteridine-containing compound biosynthetic process (GO:0042559)4.09690275
24desmosome organization (GO:0002934)4.06544010
25protein maturation by protein folding (GO:0022417)4.02319341
26response to gravity (GO:0009629)4.00300895
27IMP biosynthetic process (GO:0006188)3.95644491
28L-serine metabolic process (GO:0006563)3.88683879
29mitochondrial respiratory chain complex I assembly (GO:0032981)3.86688817
30NADH dehydrogenase complex assembly (GO:0010257)3.86688817
31mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.86688817
32negative regulation of DNA biosynthetic process (GO:2000279)3.83110598
33muscle atrophy (GO:0014889)3.70365637
34nucleoside transmembrane transport (GO:1901642)3.69185004
35polyamine biosynthetic process (GO:0006596)3.63286852
36mitochondrial RNA metabolic process (GO:0000959)3.60362272
37cell migration involved in heart development (GO:0060973)3.54713167
38nucleotide salvage (GO:0043173)3.52389235
39regulation of tight junction assembly (GO:2000810)3.49980921
40COPII vesicle coating (GO:0048208)3.42398366
41IMP metabolic process (GO:0046040)3.38720992
42regulation of gonadotropin secretion (GO:0032276)3.38000357
43cytidine catabolic process (GO:0006216)3.33985352
44cytidine deamination (GO:0009972)3.33985352
45cytidine metabolic process (GO:0046087)3.33985352
46DNA deamination (GO:0045006)3.32401397
47negative regulation of blood vessel endothelial cell migration (GO:0043537)3.32379557
48guanosine-containing compound biosynthetic process (GO:1901070)3.30063828
49response to lipoprotein particle (GO:0055094)3.26013886
50inner ear receptor cell development (GO:0060119)3.21831317
51regulation of branching involved in salivary gland morphogenesis (GO:0060693)3.21735213
52GTP biosynthetic process (GO:0006183)3.18961688
53regulation of sequestering of triglyceride (GO:0010889)3.15168965
54ribosome biogenesis (GO:0042254)3.14195492
55regulation of cellular amino acid metabolic process (GO:0006521)3.13782874
56regulation of vitamin D biosynthetic process (GO:0060556)3.12638381
57purine-containing compound salvage (GO:0043101)3.06173832
58negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)3.03130283
59serine family amino acid biosynthetic process (GO:0009070)3.02157304
60skeletal muscle tissue regeneration (GO:0043403)3.01756001
61negative regulation of Ras GTPase activity (GO:0034261)2.98389231
62rRNA modification (GO:0000154)2.98252462
63negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.95973858
64rRNA methylation (GO:0031167)2.95382894
65protein complex biogenesis (GO:0070271)2.93528452
664-hydroxyproline metabolic process (GO:0019471)2.92025612
67negative regulation of stem cell proliferation (GO:2000647)2.91776439
68tRNA modification (GO:0006400)2.89335300
69activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO2.88907205
70negative regulation of chondrocyte differentiation (GO:0032331)2.88861090
71regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.87203808
72regulation of metalloenzyme activity (GO:0048552)2.84506862
73positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.83362690
74negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.83173838
75polyamine metabolic process (GO:0006595)2.81808159
76DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.79363308
77UTP biosynthetic process (GO:0006228)2.78553900
78cellular response to zinc ion (GO:0071294)2.75334074
79cochlea development (GO:0090102)2.74317301
80COPI coating of Golgi vesicle (GO:0048205)2.74222083
81Golgi transport vesicle coating (GO:0048200)2.74222083
82negative regulation by host of viral transcription (GO:0043922)2.72687817
83establishment of viral latency (GO:0019043)2.72672660
84protein-chromophore linkage (GO:0018298)2.72262798
85positive regulation of actin filament depolymerization (GO:0030836)2.71018796
86intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.70622452
87signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.70622452
88sequestering of actin monomers (GO:0042989)2.70273526
89organic cation transport (GO:0015695)2.70163348
90regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.69513080
91phosphatidylglycerol biosynthetic process (GO:0006655)2.68850687
92extracellular fibril organization (GO:0043206)2.67152787
93protein-cofactor linkage (GO:0018065)2.66813565
94mitochondrial calcium ion transport (GO:0006851)2.66713377
95histone arginine methylation (GO:0034969)2.66143647
96peptidyl-arginine omega-N-methylation (GO:0035247)2.65887543
97tetrahydrofolate metabolic process (GO:0046653)2.65748383
98folic acid-containing compound metabolic process (GO:0006760)2.65169862
99facial nerve structural organization (GO:0021612)2.64692342
100signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.64139119

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1NOTCH1_17114293_ChIP-ChIP_T-ALL_Human4.10413692
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.80043467
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.61791582
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.27212375
5JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.07508359
6GABP_17652178_ChIP-ChIP_JURKAT_Human2.96680921
7ELF1_17652178_ChIP-ChIP_JURKAT_Human2.85033072
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.38212531
9CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.30178815
10POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.30137078
11NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.27225263
12VDR_22108803_ChIP-Seq_LS180_Human2.22356078
13PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.20635468
14BP1_19119308_ChIP-ChIP_Hs578T_Human2.19109561
15THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.09711978
16RARG_19884340_ChIP-ChIP_MEFs_Mouse2.09011519
17E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse10.5878960
18ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.99392574
19MYC_18358816_ChIP-ChIP_MESCs_Mouse1.97125443
20E2F1_18555785_ChIP-Seq_MESCs_Mouse1.83100380
21DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.79708261
22MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.77986545
23FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.76887351
24SRY_22984422_ChIP-ChIP_TESTIS_Rat1.76064813
25E2F7_22180533_ChIP-Seq_HELA_Human1.70079322
26FOXP3_21729870_ChIP-Seq_TREG_Human1.69416088
27MYC_19030024_ChIP-ChIP_MESCs_Mouse1.69324946
28EST1_17652178_ChIP-ChIP_JURKAT_Human1.68945933
29CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.67912157
30GABP_19822575_ChIP-Seq_HepG2_Human1.66225879
31SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.66080262
32HOXB4_20404135_ChIP-ChIP_EML_Mouse1.61808269
33TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.60869212
34CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.59767034
35ZNF263_19887448_ChIP-Seq_K562_Human1.59276222
36ETS1_20019798_ChIP-Seq_JURKAT_Human1.55485716
37PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.51865595
38HIF1A_21447827_ChIP-Seq_MCF-7_Human1.47680341
39ELK1_19687146_ChIP-ChIP_HELA_Human1.46651707
40THAP11_20581084_ChIP-Seq_MESCs_Mouse1.45663876
41CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.45629795
42DCP1A_22483619_ChIP-Seq_HELA_Human1.45582587
43XRN2_22483619_ChIP-Seq_HELA_Human1.45272809
44SRF_21415370_ChIP-Seq_HL-1_Mouse1.44146652
45MYC_19079543_ChIP-ChIP_MESCs_Mouse1.43758035
46NANOG_18555785_ChIP-Seq_MESCs_Mouse1.43079936
47HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.41685321
48ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.38638932
49PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.35595072
50CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.34434406
51YY1_22570637_ChIP-Seq_MALME-3M_Human1.30442998
52CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.30392358
53TBX5_21415370_ChIP-Seq_HL-1_Mouse1.29619270
54NELFA_20434984_ChIP-Seq_ESCs_Mouse1.25961626
55CREB1_15753290_ChIP-ChIP_HEK293T_Human1.25827776
56FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.18701569
57EOMES_21245162_ChIP-Seq_HESCs_Human1.17627751
58MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.13343984
59PADI4_21655091_ChIP-ChIP_MCF-7_Human1.12404403
60ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.10488491
61MYCN_18555785_ChIP-Seq_MESCs_Mouse1.08930305
62SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.06157108
63TET1_21451524_ChIP-Seq_MESCs_Mouse1.03114724
64HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.02266700
65VDR_23849224_ChIP-Seq_CD4+_Human1.01337620
66POU5F1_16153702_ChIP-ChIP_HESCs_Human0.99314426
67HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.99022363
68TP53_22127205_ChIP-Seq_IMR90_Human0.97991078
69SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.97880218
70CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.97638582
71ELK3_25401928_ChIP-Seq_HUVEC_Human0.94772873
72PU.1_20513432_ChIP-Seq_Bcells_Mouse0.93839255
73NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.93823799
74SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.92686178
75STAT6_21828071_ChIP-Seq_BEAS2B_Human0.92089011
76SOX2_22085726_ChIP-Seq_NPCs_Mouse0.91906413
77KLF4_18555785_ChIP-Seq_MESCs_Mouse0.91797184
78SOX2_18692474_ChIP-Seq_MEFs_Mouse0.90854374
79CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.88763936
80NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.87828937
81CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.87799468
82TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.85498968
83ATF3_27146783_Chip-Seq_COLON_Human0.85079109
84MYC_18555785_ChIP-Seq_MESCs_Mouse0.84928707
85PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.84899375
86MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.84554203
87RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.83606379
88SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.81688498
89SOX17_20123909_ChIP-Seq_XEN_Mouse0.81174711
90ETS1_21867929_ChIP-Seq_TH2_Mouse0.80633207
91STAT1_20625510_ChIP-Seq_HELA_Human0.80192315
92AR_21909140_ChIP-Seq_LNCAP_Human0.80099778
93BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.79495402
94SOX2_20726797_ChIP-Seq_SW620_Human0.79077574
95SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.78269731
96SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.78263264
97KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.77758200
98LXR_22292898_ChIP-Seq_THP-1_Human0.77119787
99CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.75987145
100TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.74914501

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog4.62409691
2MP0000749_muscle_degeneration3.58399109
3MP0001661_extended_life_span3.53721834
4MP0005670_abnormal_white_adipose3.42479914
5MP0005646_abnormal_pituitary_gland3.32158829
6MP0005360_urolithiasis3.30061059
7MP0005367_renal/urinary_system_phenotyp2.88400101
8MP0000516_abnormal_urinary_system2.88400101
9MP0000013_abnormal_adipose_tissue2.77942400
10MP0006054_spinal_hemorrhage2.49910681
11MP0002736_abnormal_nociception_after2.47046089
12MP0000747_muscle_weakness2.41194032
13MP0003183_abnormal_peptide_metabolism2.36204463
14MP0000750_abnormal_muscle_regeneration2.30869737
15MP0003186_abnormal_redox_activity2.23038129
16MP0001348_abnormal_lacrimal_gland2.21386512
17MP0005464_abnormal_platelet_physiology2.16007176
18MP0000647_abnormal_sebaceous_gland2.05533880
19MP0003786_premature_aging1.99636365
20MP0000534_abnormal_ureter_morphology1.97781049
21MP0003806_abnormal_nucleotide_metabolis1.92236529
22MP0004147_increased_porphyrin_level1.83612842
23MP0000751_myopathy1.73645418
24MP0000003_abnormal_adipose_tissue1.69898412
25MP0002269_muscular_atrophy1.68984948
26MP0001542_abnormal_bone_strength1.68339478
27MP0003566_abnormal_cell_adhesion1.66134334
28MP0004885_abnormal_endolymph1.64809770
29MP0008438_abnormal_cutaneous_collagen1.62486768
30MP0005165_increased_susceptibility_to1.62008037
31MP0009697_abnormal_copulation1.52234106
32MP0004272_abnormal_basement_membrane1.51523087
33MP0002938_white_spotting1.46282753
34MP0002295_abnormal_pulmonary_circulatio1.45918247
35MP0002089_abnormal_postnatal_growth/wei1.43202368
36MP0001879_abnormal_lymphatic_vessel1.41018400
37MP0000566_synostosis1.33909955
38MP0010030_abnormal_orbit_morphology1.33497280
39MP0002332_abnormal_exercise_endurance1.31178634
40MP0003942_abnormal_urinary_system1.29896442
41MP0000759_abnormal_skeletal_muscle1.28132658
42MP0010368_abnormal_lymphatic_system1.25969560
43MP0002138_abnormal_hepatobiliary_system1.24798651
44MP0003638_abnormal_response/metabolism_1.23553693
45MP0008995_early_reproductive_senescence1.22647745
46MP0001756_abnormal_urination1.20005704
47MP0006276_abnormal_autonomic_nervous1.18107776
48MP0005257_abnormal_intraocular_pressure1.16622152
49MP0008872_abnormal_physiological_respon1.13468028
50MP0001243_abnormal_dermal_layer1.11460067
51MP0005083_abnormal_biliary_tract1.08154927
52MP0009333_abnormal_splenocyte_physiolog1.07295547
53MP0001968_abnormal_touch/_nociception1.04789033
54MP0004957_abnormal_blastocyst_morpholog1.04327963
55MP0008007_abnormal_cellular_replicative1.00026099
56MP0003724_increased_susceptibility_to0.99867022
57MP0003693_abnormal_embryo_hatching0.99728871
58MP0002132_abnormal_respiratory_system0.99353680
59MP0002095_abnormal_skin_pigmentation0.98871541
60MP0001905_abnormal_dopamine_level0.98282675
61MP0002877_abnormal_melanocyte_morpholog0.96863167
62MP0004036_abnormal_muscle_relaxation0.95199443
63MP0004185_abnormal_adipocyte_glucose0.91319682
64MP0005197_abnormal_uvea_morphology0.90788028
65MP0003111_abnormal_nucleus_morphology0.90207675
66MP0004133_heterotaxia0.88587423
67MP0001340_abnormal_eyelid_morphology0.87405294
68MP0009780_abnormal_chondrocyte_physiolo0.86309682
69MP0001502_abnormal_circadian_rhythm0.84101389
70MP0002735_abnormal_chemical_nociception0.81612236
71MP0009053_abnormal_anal_canal0.80979883
72MP0008775_abnormal_heart_ventricle0.79251244
73MP0006035_abnormal_mitochondrial_morpho0.76705114
74MP0005623_abnormal_meninges_morphology0.75231884
75MP0005332_abnormal_amino_acid0.74796947
76MP0000733_abnormal_muscle_development0.69046988
77MP0004233_abnormal_muscle_weight0.65846963
78MP0000358_abnormal_cell_content/0.65742951
79MP0003195_calcinosis0.65695116
80MP0002184_abnormal_innervation0.64930363
81MP0000762_abnormal_tongue_morphology0.63201799
82MP0002837_dystrophic_cardiac_calcinosis0.62340301
83MP0004134_abnormal_chest_morphology0.62320686
84MP0000613_abnormal_salivary_gland0.61012544
85MP0005620_abnormal_muscle_contractility0.60988798
86MP0002106_abnormal_muscle_physiology0.60500298
87MP0001849_ear_inflammation0.60284068
88MP0003315_abnormal_perineum_morphology0.59537703
89MP0004087_abnormal_muscle_fiber0.59369049
90MP0005584_abnormal_enzyme/coenzyme_acti0.59211418
91MP0005084_abnormal_gallbladder_morpholo0.58741097
92MP0002148_abnormal_hypersensitivity_rea0.58533275
93MP0005595_abnormal_vascular_smooth0.58126831
94MP0001764_abnormal_homeostasis0.57870041
95MP0009643_abnormal_urine_homeostasis0.56712266
96MP0004043_abnormal_pH_regulation0.55887380
97MP0000049_abnormal_middle_ear0.55142793
98MP0005330_cardiomyopathy0.54754203
99MP0005369_muscle_phenotype0.54077775
100MP0000026_abnormal_inner_ear0.53032603

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of pyruvate family amino acid metabolism (HP:0010915)8.00424808
2Abnormality of alanine metabolism (HP:0010916)8.00424808
3Hyperalaninemia (HP:0003348)8.00424808
4Myocardial infarction (HP:0001658)5.11447277
5Constricted visual fields (HP:0001133)5.04484674
6Reduced subcutaneous adipose tissue (HP:0003758)4.58026218
7Abnormality of the fetal cardiovascular system (HP:0010948)4.54475644
8Abnormal umbilical cord blood vessels (HP:0011403)4.54475644
9Single umbilical artery (HP:0001195)4.54475644
10Conjugated hyperbilirubinemia (HP:0002908)4.29305595
11Spontaneous hematomas (HP:0007420)3.98006933
12Esophageal varix (HP:0002040)3.95518990
13Abnormality of the umbilical cord (HP:0010881)3.80479100
14Action tremor (HP:0002345)3.70244662
15Decreased electroretinogram (ERG) amplitude (HP:0000654)3.70197032
16Congenital sensorineural hearing impairment (HP:0008527)3.53062059
17Patchy hypopigmentation of hair (HP:0011365)3.42375252
18Hypoalphalipoproteinemia (HP:0003233)3.41391298
19White forelock (HP:0002211)3.27447990
20Conjunctival telangiectasia (HP:0000524)3.20998612
21Increased serum pyruvate (HP:0003542)3.08397770
22Petechiae (HP:0000967)2.97814429
23Anorexia (HP:0002039)2.97439783
24Abnormality of serum amino acid levels (HP:0003112)2.96108487
25Oligomenorrhea (HP:0000876)2.93952806
26Homocystinuria (HP:0002156)2.92460726
27Abnormality of homocysteine metabolism (HP:0010919)2.92460726
28Abnormalities of placenta or umbilical cord (HP:0001194)2.87840050
29Poor speech (HP:0002465)2.87529425
30Abnormality of glycolysis (HP:0004366)2.77790035
31Myopathic facies (HP:0002058)2.70410872
32Fatigue (HP:0012378)2.66443444
33Abnormality of sulfur amino acid metabolism (HP:0004339)2.61493128
34Delayed CNS myelination (HP:0002188)2.59295981
35Heterochromia iridis (HP:0001100)2.57014899
36Large eyes (HP:0001090)2.55538848
37Toxemia of pregnancy (HP:0100603)2.55018649
38Generalized aminoaciduria (HP:0002909)2.53960026
39Decreased subcutaneous fat (HP:0001002)2.51055834
40Palpebral edema (HP:0100540)2.48361544
41Polygenic inheritance (HP:0010982)2.42136971
42Abnormality of the vasculature of the conjunctiva (HP:0008054)2.41390401
43Cholecystitis (HP:0001082)2.38604230
44Abnormal gallbladder physiology (HP:0012438)2.38604230
45Nausea (HP:0002018)2.33863572
46Adrenal hypoplasia (HP:0000835)2.29557102
47Menorrhagia (HP:0000132)2.26006650
48Mesomelia (HP:0003027)2.25628554
49Insulin-resistant diabetes mellitus (HP:0000831)2.25301550
50Difficulty climbing stairs (HP:0003551)2.24940861
51Cortical visual impairment (HP:0100704)2.23177763
52Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.21867345
53Hyperlipoproteinemia (HP:0010980)2.16523219
54Wrist flexion contracture (HP:0001239)2.14517958
55Cavernous hemangioma (HP:0001048)2.13023722
56Ileus (HP:0002595)2.11008916
57Delayed gross motor development (HP:0002194)2.07096435
58Vascular calcification (HP:0004934)2.06670079
59Birth length less than 3rd percentile (HP:0003561)2.02372371
60Elevated erythrocyte sedimentation rate (HP:0003565)2.01865269
61Shoulder girdle muscle weakness (HP:0003547)2.01054362
62Hypergammaglobulinemia (HP:0010702)2.01005990
63Spinal muscular atrophy (HP:0007269)2.00720684
64Premature rupture of membranes (HP:0001788)2.00014866
65Abnormality of placental membranes (HP:0011409)1.99759853
66Amniotic constriction ring (HP:0009775)1.99759853
67Type I transferrin isoform profile (HP:0003642)1.98842395
68Increased purine levels (HP:0004368)1.98745508
69Hyperuricemia (HP:0002149)1.98745508
70Paralysis (HP:0003470)1.98042968
71Nemaline bodies (HP:0003798)1.93856550
72Postural tremor (HP:0002174)1.91021236
73Aplasia/hypoplasia of the uterus (HP:0008684)1.89991942
74Hypophosphatemic rickets (HP:0004912)1.89529016
75Purpura (HP:0000979)1.89133523
76Maternal diabetes (HP:0009800)1.86010679
77Exercise-induced muscle cramps (HP:0003710)1.84927463
78Cardiovascular calcification (HP:0011915)1.84760981
79Pelvic girdle muscle weakness (HP:0003749)1.84283091
80Stenosis of the external auditory canal (HP:0000402)1.82963069
81Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.81160774
82Autoimmune hemolytic anemia (HP:0001890)1.78888105
83Biconcave vertebral bodies (HP:0004586)1.78335135
84Short tibia (HP:0005736)1.73875938
85Median cleft lip (HP:0000161)1.73556727
86Metabolic acidosis (HP:0001942)1.73111335
87Methylmalonic aciduria (HP:0012120)1.72741441
88Abnormality of subcutaneous fat tissue (HP:0001001)1.70972635
89Reduced antithrombin III activity (HP:0001976)1.70382332
90Ectopic anus (HP:0004397)1.69900062
91Fibular aplasia (HP:0002990)1.67245980
92Abnormality of the renal collecting system (HP:0004742)1.66645415
93Abnormality of the hip-girdle musculature (HP:0001445)1.65207010
94Abnormality of the musculature of the pelvis (HP:0001469)1.65207010
95Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.62332990
96Hypoplastic left heart (HP:0004383)1.60921790
97Supernumerary spleens (HP:0009799)1.60345643
98Insulin resistance (HP:0000855)1.59151844
99Myoglobinuria (HP:0002913)1.58661802
100Duplicated collecting system (HP:0000081)1.58260377

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LMTK24.42990499
2BUB14.12070182
3VRK23.91878007
4TESK23.49130129
5MAP3K32.98837396
6TESK12.84368183
7PHKG22.61510578
8PHKG12.61510578
9LIMK12.48484510
10FER2.37224642
11MST42.32872397
12NME22.31584574
13MAP2K32.30202124
14PAK42.25283899
15FES2.23628670
16CCNB12.19812089
17JAK32.17472153
18CDK92.01262211
19EPHB21.99483856
20KDR1.99420243
21PLK21.84278991
22ARAF1.64352091
23AURKA1.62673395
24FGR1.60166429
25VRK11.55164381
26MAP2K71.53726544
27EPHA21.48635856
28STK161.47345530
29ACVR1B1.38362242
30MYLK1.38239772
31SMG11.29951488
32DAPK11.09747925
33PIM21.04813139
34ILK1.04523270
35BCKDK1.04103758
36SGK4941.03808003
37SGK2231.03808003
38PBK0.95827484
39SRPK10.93554310
40PLK30.92937183
41TIE10.91757305
42MAP3K120.90870791
43EIF2AK10.88148705
44PAK10.86666367
45ABL20.85873844
46NTRK20.81634632
47PRKCE0.80730924
48AKT30.78933682
49GRK50.78459470
50DYRK20.78439285
51CSNK1A10.78117027
52MOS0.77945007
53ADRBK10.77728884
54STK100.77145212
55PRKCI0.76236127
56PRKD30.76223552
57CSNK1G30.75992339
58TAF10.75121325
59RPS6KB20.74838864
60SGK20.72030125
61ERBB30.71515986
62MST1R0.70836399
63DAPK30.66696575
64NUAK10.65831410
65BRAF0.61198906
66CAMK2G0.57477534
67CSNK1G10.57398358
68BRSK10.53879620
69MAPKAPK30.53257417
70ERBB40.52758809
71MAP3K110.52344551
72CSNK1A1L0.50214237
73AKT20.48600938
74MAP2K10.47358452
75SGK30.46935137
76MAP4K20.45042080
77CHEK20.44658247
78BMX0.43026288
79CSNK1G20.42863900
80CDK70.41459579
81PAK20.39411095
82TLK10.39231589
83FGFR10.39137629
84CAMKK20.36177299
85BCR0.33682380
86PTK2B0.33532968
87IKBKB0.32462415
88PRKCQ0.32430297
89PRKCD0.32045624
90HIPK20.31819629
91PRKD10.31776074
92CAMK10.30374790
93NEK90.30109468
94GSK3A0.29910703
95PTK60.26778893
96PRKCA0.26724568
97CSNK2A10.26617181
98CAMK2D0.26011074
99ROCK20.24699750
100PTK20.23984009

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030505.46799079
22-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.96456554
3Biosynthesis of amino acids_Homo sapiens_hsa012303.18672048
4Sulfur metabolism_Homo sapiens_hsa009203.06676913
5Galactose metabolism_Homo sapiens_hsa000522.97106024
6Collecting duct acid secretion_Homo sapiens_hsa049662.83633338
7Pentose phosphate pathway_Homo sapiens_hsa000302.80174965
8Sulfur relay system_Homo sapiens_hsa041222.71476059
9One carbon pool by folate_Homo sapiens_hsa006702.68694885
10Vibrio cholerae infection_Homo sapiens_hsa051102.29158045
11Arginine biosynthesis_Homo sapiens_hsa002202.22098067
12Folate biosynthesis_Homo sapiens_hsa007902.17091605
13Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.98643938
14Carbon metabolism_Homo sapiens_hsa012001.89528751
15Cysteine and methionine metabolism_Homo sapiens_hsa002701.86665652
16Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.84715455
17Oxidative phosphorylation_Homo sapiens_hsa001901.73710482
18Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.68389141
19Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.67681345
20Synaptic vesicle cycle_Homo sapiens_hsa047211.52037040
21Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.51789957
22Maturity onset diabetes of the young_Homo sapiens_hsa049501.48046273
23Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.45524228
24Mismatch repair_Homo sapiens_hsa034301.39688170
25Base excision repair_Homo sapiens_hsa034101.33715681
26Parkinsons disease_Homo sapiens_hsa050121.31354622
27DNA replication_Homo sapiens_hsa030301.30549432
28Glutathione metabolism_Homo sapiens_hsa004801.29965452
29Rheumatoid arthritis_Homo sapiens_hsa053231.22190719
30Steroid biosynthesis_Homo sapiens_hsa001001.21726463
31Nucleotide excision repair_Homo sapiens_hsa034201.08883975
32GABAergic synapse_Homo sapiens_hsa047271.08652856
33Selenocompound metabolism_Homo sapiens_hsa004501.07584177
34Basal transcription factors_Homo sapiens_hsa030221.06454398
35Fatty acid elongation_Homo sapiens_hsa000621.06420887
36Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.06312940
37Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.05015721
38Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.04926769
39Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.03951085
40Huntingtons disease_Homo sapiens_hsa050161.00716286
41Alzheimers disease_Homo sapiens_hsa050100.98821761
42Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.98524675
43Regulation of autophagy_Homo sapiens_hsa041400.97846753
44SNARE interactions in vesicular transport_Homo sapiens_hsa041300.97644681
45Protein export_Homo sapiens_hsa030600.94553309
46mRNA surveillance pathway_Homo sapiens_hsa030150.90293881
47Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.86705481
48N-Glycan biosynthesis_Homo sapiens_hsa005100.82109765
49Alcoholism_Homo sapiens_hsa050340.81714184
50Cyanoamino acid metabolism_Homo sapiens_hsa004600.79166046
51Fructose and mannose metabolism_Homo sapiens_hsa000510.78995483
52Spliceosome_Homo sapiens_hsa030400.75574625
53Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.74437632
54Homologous recombination_Homo sapiens_hsa034400.72334159
55Arginine and proline metabolism_Homo sapiens_hsa003300.71919756
56Morphine addiction_Homo sapiens_hsa050320.70669735
57Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.69089066
58RNA transport_Homo sapiens_hsa030130.62949438
59Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.62288027
60Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.61672095
61Pyrimidine metabolism_Homo sapiens_hsa002400.59327862
62Thyroid cancer_Homo sapiens_hsa052160.58900398
63Dopaminergic synapse_Homo sapiens_hsa047280.56250828
64Salmonella infection_Homo sapiens_hsa051320.55469815
65Metabolic pathways_Homo sapiens_hsa011000.55214785
66Vitamin digestion and absorption_Homo sapiens_hsa049770.54568645
67Peroxisome_Homo sapiens_hsa041460.52807901
68Serotonergic synapse_Homo sapiens_hsa047260.51909433
69Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.51743189
70Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.50501993
71RNA polymerase_Homo sapiens_hsa030200.49918373
72Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.49084201
73Pyruvate metabolism_Homo sapiens_hsa006200.48627490
74Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.48320259
75Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.45779469
76RNA degradation_Homo sapiens_hsa030180.44883905
77Hedgehog signaling pathway_Homo sapiens_hsa043400.43818656
78Nitrogen metabolism_Homo sapiens_hsa009100.41103492
79p53 signaling pathway_Homo sapiens_hsa041150.40624507
80Purine metabolism_Homo sapiens_hsa002300.40326159
81Starch and sucrose metabolism_Homo sapiens_hsa005000.40160808
82Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.37224489
83Lysosome_Homo sapiens_hsa041420.33865450
84Tight junction_Homo sapiens_hsa045300.33311966
85Endocytosis_Homo sapiens_hsa041440.30978725
86Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.27352694
87Apoptosis_Homo sapiens_hsa042100.26113452
88Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.25786778
89Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.24893133
90Hippo signaling pathway_Homo sapiens_hsa043900.23350100
91Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.22504642
92Mineral absorption_Homo sapiens_hsa049780.20802366
93Renin-angiotensin system_Homo sapiens_hsa046140.19841386
94Pentose and glucuronate interconversions_Homo sapiens_hsa000400.19000391
95Salivary secretion_Homo sapiens_hsa049700.18090815
96Adherens junction_Homo sapiens_hsa045200.18011454
97Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.15411637
98Cholinergic synapse_Homo sapiens_hsa047250.14655540
99Fanconi anemia pathway_Homo sapiens_hsa034600.14274759
100Shigellosis_Homo sapiens_hsa051310.13477197

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »