PKMYT1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the serine/threonine protein kinase family. The encoded protein is a membrane-associated kinase that negatively regulates the G2/M transition of the cell cycle by phosphorylating and inactivating cyclin-dependent kinase 1. The activity of the encoded protein is regulated by polo-like kinase 1. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA strand elongation involved in DNA replication (GO:0006271)6.36697413
2DNA unwinding involved in DNA replication (GO:0006268)6.19341279
3telomere maintenance via semi-conservative replication (GO:0032201)6.06516782
4DNA strand elongation (GO:0022616)6.04147329
5DNA replication initiation (GO:0006270)5.70378405
6DNA replication checkpoint (GO:0000076)5.35211515
7telomere maintenance via recombination (GO:0000722)5.17604036
8mitotic recombination (GO:0006312)4.88982470
9DNA deamination (GO:0045006)4.73042787
10nucleotide-excision repair, DNA gap filling (GO:0006297)4.58939254
11protein localization to kinetochore (GO:0034501)4.39293333
12telomere maintenance via telomere lengthening (GO:0010833)4.36588969
13regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)4.30928700
14ribosomal small subunit biogenesis (GO:0042274)4.28191836
15viral transcription (GO:0019083)4.10773012
16regulation of translational fidelity (GO:0006450)4.06976265
17DNA replication-dependent nucleosome assembly (GO:0006335)3.96738320
18DNA replication-dependent nucleosome organization (GO:0034723)3.96738320
19translational termination (GO:0006415)3.95053897
20protein localization to chromosome, centromeric region (GO:0071459)3.85431242
21proline biosynthetic process (GO:0006561)3.68471635
22chromatin remodeling at centromere (GO:0031055)3.64777343
23protein targeting to ER (GO:0045047)3.60519234
24DNA synthesis involved in DNA repair (GO:0000731)3.59875295
25chromosome condensation (GO:0030261)3.59643251
26folic acid metabolic process (GO:0046655)3.56451555
27deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.55101765
28mitotic sister chromatid segregation (GO:0000070)3.53445380
29nuclear pore complex assembly (GO:0051292)3.52954943
30ribosomal small subunit assembly (GO:0000028)3.51286339
31meiotic chromosome segregation (GO:0045132)3.49817014
32CENP-A containing nucleosome assembly (GO:0034080)3.49478526
33translational elongation (GO:0006414)3.47283183
34mitotic sister chromatid cohesion (GO:0007064)3.47121208
35L-serine metabolic process (GO:0006563)3.44846855
36SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.43974030
37regulation of mammary gland epithelial cell proliferation (GO:0033599)3.43584175
38establishment of protein localization to endoplasmic reticulum (GO:0072599)3.43389971
39DNA topological change (GO:0006265)3.42592688
40cotranslational protein targeting to membrane (GO:0006613)3.42119326
41mitotic G2/M transition checkpoint (GO:0044818)3.39750582
42protein localization to endoplasmic reticulum (GO:0070972)3.36655731
43nucleobase-containing small molecule interconversion (GO:0015949)3.33719360
44pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.33679457
45establishment of integrated proviral latency (GO:0075713)3.31974498
46DNA strand renaturation (GO:0000733)3.30841174
47viral life cycle (GO:0019058)3.30195345
48pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.29906626
49nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.28660490
50regulation of double-strand break repair via homologous recombination (GO:0010569)3.27548336
51mitotic chromosome condensation (GO:0007076)3.23853550
52DNA replication-independent nucleosome assembly (GO:0006336)3.23469422
53DNA replication-independent nucleosome organization (GO:0034724)3.23469422
54maturation of SSU-rRNA (GO:0030490)3.22816856
55translational initiation (GO:0006413)3.22195230
56translesion synthesis (GO:0019985)3.20938267
57formation of translation preinitiation complex (GO:0001731)3.20861404
58DNA duplex unwinding (GO:0032508)3.20817249
59mitotic G2 DNA damage checkpoint (GO:0007095)3.20810751
60protein neddylation (GO:0045116)3.19748501
61chromatin assembly (GO:0031497)3.18590018
62DNA geometric change (GO:0032392)3.17537777
63folic acid-containing compound biosynthetic process (GO:0009396)3.16787130
64regulation of nuclear cell cycle DNA replication (GO:0033262)3.16174745
65deoxyribonucleotide biosynthetic process (GO:0009263)3.16139971
66peptidyl-arginine omega-N-methylation (GO:0035247)3.15422375
67DNA packaging (GO:0006323)3.13398042
68viral mRNA export from host cell nucleus (GO:0046784)3.11404478
69cellular protein complex disassembly (GO:0043624)3.10353304
70protein complex localization (GO:0031503)3.09846284
71nuclear pore organization (GO:0006999)3.09582850
72sister chromatid segregation (GO:0000819)3.08754550
73positive regulation of DNA-dependent DNA replication (GO:2000105)3.08314212
74establishment of viral latency (GO:0019043)3.07341310
75negative regulation of mRNA metabolic process (GO:1903312)3.06988528
76telomere organization (GO:0032200)3.06458052
77telomere maintenance (GO:0000723)3.06218844
78positive regulation of chromosome segregation (GO:0051984)3.03794972
79regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.03505772
80maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.02676143
81base-excision repair (GO:0006284)3.02635922
82nucleobase biosynthetic process (GO:0046112)3.02564217
83chromosome segregation (GO:0007059)2.99889541
84attachment of spindle microtubules to kinetochore (GO:0008608)2.98820928
85DNA ligation (GO:0006266)2.95906355
86regulation of mitochondrial translation (GO:0070129)2.93470400
87mitotic nuclear envelope disassembly (GO:0007077)2.91513702
88negative regulation of macroautophagy (GO:0016242)2.91291080
89kinetochore organization (GO:0051383)2.90506703
90mismatch repair (GO:0006298)2.90119231
91ribosome biogenesis (GO:0042254)2.89638084
92pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.89129688
93transcription-coupled nucleotide-excision repair (GO:0006283)2.88577850
94regulation of sister chromatid cohesion (GO:0007063)2.87704539
95pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.87128135
96protein complex disassembly (GO:0043241)2.85555784
97chromatin assembly or disassembly (GO:0006333)2.85526955
98heterochromatin organization (GO:0070828)2.85364673
99exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.83026212
100DNA damage response, signal transduction resulting in transcription (GO:0042772)2.82892368
101histone exchange (GO:0043486)2.82428573
102proteasome assembly (GO:0043248)2.82395150
103rRNA transcription (GO:0009303)2.81975731
104histone arginine methylation (GO:0034969)2.81817792
105UTP biosynthetic process (GO:0006228)2.81770352
1062-deoxyribonucleotide biosynthetic process (GO:0009265)2.81499504
107deoxyribose phosphate biosynthetic process (GO:0046385)2.81499504
108negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.79999621
109spliceosomal tri-snRNP complex assembly (GO:0000244)2.79947185
110* cell cycle G1/S phase transition (GO:0044843)2.79562777
111* G1/S transition of mitotic cell cycle (GO:0000082)2.79562777
112DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.79545103
113nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.78340634
114DNA biosynthetic process (GO:0071897)2.77536358
115DNA conformation change (GO:0071103)2.77177175
116metaphase plate congression (GO:0051310)2.76002219
117regulation of protein heterodimerization activity (GO:0043497)2.75369414
118mitotic DNA integrity checkpoint (GO:0044774)2.75317276
119DNA replication (GO:0006260)2.74938027
120protein localization to chromosome (GO:0034502)2.74705738
121mitotic metaphase plate congression (GO:0007080)2.74618894
122pore complex assembly (GO:0046931)2.73634851
123regulation of DNA-dependent DNA replication (GO:0090329)2.72970560
124rRNA processing (GO:0006364)2.72079091
125guanosine-containing compound biosynthetic process (GO:1901070)2.70092686
126negative regulation of RNA splicing (GO:0033119)2.69440691
127ribonucleoprotein complex biogenesis (GO:0022613)2.66978373
128purine nucleobase biosynthetic process (GO:0009113)2.66228596
129nuclear-transcribed mRNA catabolic process (GO:0000956)2.66049208
130mitotic DNA damage checkpoint (GO:0044773)2.65345288
131ncRNA 3-end processing (GO:0043628)2.64833792
132negative regulation of mRNA processing (GO:0050686)2.64192026
133rRNA metabolic process (GO:0016072)2.62900215
134negative regulation of DNA-templated transcription, elongation (GO:0032785)2.62217061
135negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.62217061
136kinetochore assembly (GO:0051382)2.61935027
137nuclear envelope reassembly (GO:0031468)2.61714277
138mitotic nuclear envelope reassembly (GO:0007084)2.61714277
139nuclear envelope disassembly (GO:0051081)2.61598325
140membrane disassembly (GO:0030397)2.61598325
141somatic hypermutation of immunoglobulin genes (GO:0016446)2.60649601
142somatic diversification of immune receptors via somatic mutation (GO:0002566)2.60649601
143pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.60367348
144macromolecular complex disassembly (GO:0032984)2.60319404

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human3.89469278
2E2F4_17652178_ChIP-ChIP_JURKAT_Human3.62265302
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.45598476
4SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.37382026
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.33720476
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.98840660
7MYC_18358816_ChIP-ChIP_MESCs_Mouse2.51367018
8MYC_19079543_ChIP-ChIP_MESCs_Mouse2.47934992
9KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.46407280
10EST1_17652178_ChIP-ChIP_JURKAT_Human2.43275727
11MYC_19030024_ChIP-ChIP_MESCs_Mouse2.27185928
12JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.23446643
13TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.20755149
14HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.18715535
15ELF1_17652178_ChIP-ChIP_JURKAT_Human2.18708243
16ETS1_20019798_ChIP-Seq_JURKAT_Human2.18174803
17XRN2_22483619_ChIP-Seq_HELA_Human2.15096538
18MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.11880769
19CREB1_15753290_ChIP-ChIP_HEK293T_Human2.10516045
20GABP_17652178_ChIP-ChIP_JURKAT_Human2.09810381
21* E2F1_21310950_ChIP-Seq_MCF-7_Human2.08539912
22NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.08261243
23AR_21909140_ChIP-Seq_LNCAP_Human2.08117618
24VDR_21846776_ChIP-Seq_THP-1_Human2.07038107
25E2F7_22180533_ChIP-Seq_HELA_Human10.6516660
26MYC_22102868_ChIP-Seq_BL_Human1.99848772
27CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.95990494
28SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.90430416
29VDR_23849224_ChIP-Seq_CD4+_Human1.81135894
30* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.71566720
31ZNF263_19887448_ChIP-Seq_K562_Human1.70724653
32FOXP3_21729870_ChIP-Seq_TREG_Human1.66848048
33NELFA_20434984_ChIP-Seq_ESCs_Mouse1.64467211
34MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.63663820
35DCP1A_22483619_ChIP-Seq_HELA_Human1.61479451
36MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.59918883
37* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.55587554
38CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.54686274
39NANOG_18555785_ChIP-Seq_MESCs_Mouse1.51327609
40GABP_19822575_ChIP-Seq_HepG2_Human1.50810566
41THAP11_20581084_ChIP-Seq_MESCs_Mouse1.48759348
42CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.48482544
43CIITA_25753668_ChIP-Seq_RAJI_Human1.47092210
44* LXR_22292898_ChIP-Seq_THP-1_Human1.45727075
45TTF2_22483619_ChIP-Seq_HELA_Human1.45489443
46MYCN_18555785_ChIP-Seq_MESCs_Mouse1.42504813
47ESR1_15608294_ChIP-ChIP_MCF-7_Human1.41723615
48HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.38831584
49SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.38090836
50YY1_21170310_ChIP-Seq_MESCs_Mouse1.37676272
51PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.35339026
52TET1_21451524_ChIP-Seq_MESCs_Mouse1.33963476
53E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.32275099
54FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.30701221
55POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.30069646
56CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.29572193
57* RACK7_27058665_Chip-Seq_MCF-7_Human1.29432488
58KDM5A_27292631_Chip-Seq_BREAST_Human1.29364501
59* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.29088808
60CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.28649953
61ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.28539056
62P68_20966046_ChIP-Seq_HELA_Human1.26303442
63* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.24702219
64PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.23988058
65ELK3_25401928_ChIP-Seq_HUVEC_Human1.23135412
66KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.22262246
67HOXB4_20404135_ChIP-ChIP_EML_Mouse1.20101728
68* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.19412973
69ZFX_18555785_ChIP-Seq_MESCs_Mouse1.17486150
70SPI1_23547873_ChIP-Seq_NB4_Human1.15375334
71* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.14423547
72KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.12175751
73KLF4_18555785_ChIP-Seq_MESCs_Mouse1.11868282
74SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.11154965
75YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.10720146
76* SCL_19346495_ChIP-Seq_HPC-7_Human1.09966529
77SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.09759760
78* FOXP1_21924763_ChIP-Seq_HESCs_Human1.08489452
79GATA1_22383799_ChIP-Seq_G1ME_Mouse1.07918571
80MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.07792510
81CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.06844739
82VDR_24763502_ChIP-Seq_THP-1_Human1.06242441
83CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.06237322
84MAF_26560356_Chip-Seq_TH1_Human1.05867930
85BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.05457238
86DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.04373710
87HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.04320348
88CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.03108408
89EGR1_19374776_ChIP-ChIP_THP-1_Human1.02470219
90ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.01700105
91RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.00455602
92MYB_21317192_ChIP-Seq_ERMYB_Mouse0.99827855
93ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.99520218
94RUNX1_22412390_ChIP-Seq_EML_Mouse0.98380296
95UTX_26944678_Chip-Seq_JUKART_Human0.97383542
96NCOR1_26117541_ChIP-Seq_K562_Human0.97012619
97SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.96892452
98TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.96295114
99TBX5_21415370_ChIP-Seq_HL-1_Mouse0.96224562
100SRY_22984422_ChIP-ChIP_TESTIS_Rat0.95797469
101ATF3_27146783_Chip-Seq_COLON_Human0.95202895
102ELK1_19687146_ChIP-ChIP_HELA_Human0.95040143
103GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.94518010
104POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.94187528
105CTCF_18555785_ChIP-Seq_MESCs_Mouse0.93343333
106SRF_21415370_ChIP-Seq_HL-1_Mouse0.93078078
107* MAF_26560356_Chip-Seq_TH2_Human0.92619481
108IRF1_19129219_ChIP-ChIP_H3396_Human0.91538888
109TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.90871190
110SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.90825300
111SA1_27219007_Chip-Seq_ERYTHROID_Human0.90453592
112KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.89935650
113RARA_24833708_ChIP-Seq_LIVER_Mouse0.87560654
114DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.87431726
115STAT3_1855785_ChIP-Seq_MESCs_Mouse0.87032883
116STAT4_19710469_ChIP-ChIP_TH1__Mouse0.86070061
117MYB_26560356_Chip-Seq_TH2_Human0.86012129
118CTCF_27219007_Chip-Seq_ERYTHROID_Human0.85646935
119YY1_22570637_ChIP-Seq_MALME-3M_Human0.85598770
120SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.85237759
121POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.84556613
122MYB_26560356_Chip-Seq_TH1_Human0.84097797
123TP63_19390658_ChIP-ChIP_HaCaT_Human0.83503953
124NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.83396816
125TFEB_21752829_ChIP-Seq_HELA_Human0.82944095
126SOX2_18555785_ChIP-Seq_MESCs_Mouse0.82751930
127KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.82413130
128* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.81579360
129IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.80702030
130MYC_18940864_ChIP-ChIP_HL60_Human0.80672519
131STAT6_21828071_ChIP-Seq_BEAS2B_Human0.80171594
132ELF1_20517297_ChIP-Seq_JURKAT_Human0.79986578
133TP63_17297297_ChIP-ChIP_HaCaT_Human0.75986314

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication4.79579843
2MP0010094_abnormal_chromosome_stability4.40474807
3MP0003693_abnormal_embryo_hatching4.40439472
4MP0003111_abnormal_nucleus_morphology3.80164939
5MP0004957_abnormal_blastocyst_morpholog3.59674302
6MP0003077_abnormal_cell_cycle3.42913756
7MP0003283_abnormal_digestive_organ3.02834036
8MP0002396_abnormal_hematopoietic_system2.93199388
9MP0008932_abnormal_embryonic_tissue2.61357620
10MP0003705_abnormal_hypodermis_morpholog2.41028821
11MP0008058_abnormal_DNA_repair2.32766182
12MP0010030_abnormal_orbit_morphology2.17936467
13MP0003763_abnormal_thymus_physiology2.09686252
14MP0009333_abnormal_splenocyte_physiolog2.06444929
15MP0000350_abnormal_cell_proliferation2.03091525
16MP0005076_abnormal_cell_differentiation1.95953079
17MP0000490_abnormal_crypts_of1.95428650
18MP0002877_abnormal_melanocyte_morpholog1.90807119
19MP0003315_abnormal_perineum_morphology1.86020900
20MP0001730_embryonic_growth_arrest1.85492317
21MP0000678_abnormal_parathyroid_gland1.72399275
22MP0002398_abnormal_bone_marrow1.71440138
23MP0008007_abnormal_cellular_replicative1.70641056
24MP0010352_gastrointestinal_tract_polyps1.67799821
25MP0001346_abnormal_lacrimal_gland1.66412737
26MP0005075_abnormal_melanosome_morpholog1.66245987
27MP0002019_abnormal_tumor_incidence1.64040432
28MP0000537_abnormal_urethra_morphology1.57010275
29MP0004233_abnormal_muscle_weight1.55496715
30MP0009379_abnormal_foot_pigmentation1.52722150
31MP0001545_abnormal_hematopoietic_system1.51137857
32MP0005397_hematopoietic_system_phenotyp1.51137857
33MP0008877_abnormal_DNA_methylation1.50902085
34MP0009672_abnormal_birth_weight1.49897918
35MP0000689_abnormal_spleen_morphology1.49741590
36MP0002249_abnormal_larynx_morphology1.49041999
37MP0000685_abnormal_immune_system1.48170201
38MP0002722_abnormal_immune_system1.46685116
39MP0000703_abnormal_thymus_morphology1.43095631
40MP0000313_abnormal_cell_death1.42792370
41MP0000462_abnormal_digestive_system1.42759276
42MP0003656_abnormal_erythrocyte_physiolo1.42549108
43MP0003123_paternal_imprinting1.37420906
44MP0001800_abnormal_humoral_immune1.32166627
45MP0002163_abnormal_gland_morphology1.31992706
46MP0004808_abnormal_hematopoietic_stem1.30767217
47MP0002429_abnormal_blood_cell1.30014294
48MP0000716_abnormal_immune_system1.26752624
49MP0010234_abnormal_vibrissa_follicle1.26311063
50MP0005671_abnormal_response_to1.25653261
51MP0002420_abnormal_adaptive_immunity1.23689797
52MP0000566_synostosis1.22780108
53MP0005451_abnormal_body_composition1.21595567
54MP0001819_abnormal_immune_cell1.21283375
55MP0002080_prenatal_lethality1.20116010
56MP0002796_impaired_skin_barrier1.19950541
57MP0002405_respiratory_system_inflammati1.17639095
58MP0001188_hyperpigmentation1.16355750
59MP0002234_abnormal_pharynx_morphology1.16166882
60MP0000465_gastrointestinal_hemorrhage1.16088593
61MP0001661_extended_life_span1.15486579
62MP0003786_premature_aging1.15363901
63MP0001697_abnormal_embryo_size1.15341138
64MP0003806_abnormal_nucleotide_metabolis1.14577708
65MP0002160_abnormal_reproductive_system1.13773681
66MP0002085_abnormal_embryonic_tissue1.13451153
67MP0005000_abnormal_immune_tolerance1.11217317
68MP0002723_abnormal_immune_serum1.11010251
69MP0009053_abnormal_anal_canal1.10876197
70MP0002452_abnormal_antigen_presenting1.08713668
71MP0005025_abnormal_response_to1.08427986
72MP0005623_abnormal_meninges_morphology1.08255438
73MP0004381_abnormal_hair_follicle1.07496913
74MP0009278_abnormal_bone_marrow1.06812506
75MP0010307_abnormal_tumor_latency1.06140203
76MP0005380_embryogenesis_phenotype1.05832188
77MP0001672_abnormal_embryogenesis/_devel1.05832188
78MP0006035_abnormal_mitochondrial_morpho1.05195548
79MP0003866_abnormal_defecation1.03030107
80MP0000003_abnormal_adipose_tissue1.02756664
81MP0001849_ear_inflammation1.02167768
82MP0005171_absent_coat_pigmentation1.01534863
83MP0002697_abnormal_eye_size1.01135948
84MP0001835_abnormal_antigen_presentation1.00292177
85MP0001293_anophthalmia1.00174290
86MP0003566_abnormal_cell_adhesion0.99655661
87MP0001929_abnormal_gametogenesis0.99609763
88MP0005174_abnormal_tail_pigmentation0.99349928
89MP0003453_abnormal_keratinocyte_physiol0.98319612
90MP0002084_abnormal_developmental_patter0.97558972
91MP0001145_abnormal_male_reproductive0.96462256
92MP0002210_abnormal_sex_determination0.96387676
93MP0005387_immune_system_phenotype0.96187523
94MP0001790_abnormal_immune_system0.96187523
95MP0005410_abnormal_fertilization0.94906764
96MP0000477_abnormal_intestine_morphology0.93552857
97MP0002098_abnormal_vibrissa_morphology0.93339684
98MP0009785_altered_susceptibility_to0.91337862
99MP0000858_altered_metastatic_potential0.91153536
100MP0004947_skin_inflammation0.90861818
101MP0002086_abnormal_extraembryonic_tissu0.89827237
102MP0003942_abnormal_urinary_system0.89396045
103MP0001529_abnormal_vocalization0.89141483
104MP0000049_abnormal_middle_ear0.88980663
105MP0010678_abnormal_skin_adnexa0.88134710
106MP0000383_abnormal_hair_follicle0.87022021
107MP0005621_abnormal_cell_physiology0.86771916
108MP0003984_embryonic_growth_retardation0.86634283
109MP0004858_abnormal_nervous_system0.86126856
110MP0000377_abnormal_hair_follicle0.84145003
111MP0003937_abnormal_limbs/digits/tail_de0.83202932
112MP0002088_abnormal_embryonic_growth/wei0.81898289
113MP0002132_abnormal_respiratory_system0.81878499
114MP0005384_cellular_phenotype0.81843146
115MP0004197_abnormal_fetal_growth/weight/0.80742871
116MP0005501_abnormal_skin_physiology0.79994491
117MP0009697_abnormal_copulation0.78900378
118MP0001348_abnormal_lacrimal_gland0.78126395
119MP0000613_abnormal_salivary_gland0.77955670
120MP0003718_maternal_effect0.77537054
121MP0003861_abnormal_nervous_system0.76739987
122MP0001881_abnormal_mammary_gland0.76644994
123MP0006054_spinal_hemorrhage0.76186129
124MP0005464_abnormal_platelet_physiology0.75982092
125MP0000358_abnormal_cell_content/0.75285801
126MP0002751_abnormal_autonomic_nervous0.74289766
127MP0000653_abnormal_sex_gland0.73133087
128MP0006292_abnormal_olfactory_placode0.72105485
129MP0002089_abnormal_postnatal_growth/wei0.71485130
130MP0003385_abnormal_body_wall0.71426304
131MP0002095_abnormal_skin_pigmentation0.71022842
132MP0000920_abnormal_myelination0.70436728
133MP0004185_abnormal_adipocyte_glucose0.68920070
134MP0005666_abnormal_adipose_tissue0.68800990
135MP0006082_CNS_inflammation0.68740580
136MP0002092_abnormal_eye_morphology0.67986187
137MP0006036_abnormal_mitochondrial_physio0.67885495
138MP0002111_abnormal_tail_morphology0.67570569
139MP0002060_abnormal_skin_morphology0.66152841
140MP0000579_abnormal_nail_morphology0.66068919
141MP0010771_integument_phenotype0.65653944
142MP0003699_abnormal_female_reproductive0.65259197
143MP0009931_abnormal_skin_appearance0.65168518
144MP0008995_early_reproductive_senescence0.64887163
145MP0001216_abnormal_epidermal_layer0.64660186
146MP0003136_yellow_coat_color0.64055165
147MP0000467_abnormal_esophagus_morphology0.63075083
148MP0005330_cardiomyopathy0.62790392
149MP0002161_abnormal_fertility/fecundity0.62427320

Predicted human phenotypes

RankGene SetZ-score
1Breast hypoplasia (HP:0003187)5.54039197
2Abnormal number of erythroid precursors (HP:0012131)4.76114635
3Abnormality of cells of the erythroid lineage (HP:0012130)4.70351199
4Birth length less than 3rd percentile (HP:0003561)4.36978822
5Reticulocytopenia (HP:0001896)4.01579003
6Irregular epiphyses (HP:0010582)3.66520541
7Patellar aplasia (HP:0006443)3.48829865
8Chromsome breakage (HP:0040012)3.30745113
9Chromosomal breakage induced by crosslinking agents (HP:0003221)3.27574004
10Aplasia/Hypoplasia of the patella (HP:0006498)3.20765027
11Progressive muscle weakness (HP:0003323)3.19932278
12Microvesicular hepatic steatosis (HP:0001414)3.11296169
13Flat capital femoral epiphysis (HP:0003370)3.07926567
14Poikiloderma (HP:0001029)3.06913835
15Posterior subcapsular cataract (HP:0007787)3.05587344
16Exertional dyspnea (HP:0002875)3.05253430
17Testicular atrophy (HP:0000029)2.98144498
18Squamous cell carcinoma (HP:0002860)2.94442432
19Pallor (HP:0000980)2.93146775
20Hyperacusis (HP:0010780)2.89631283
21Broad distal phalanx of finger (HP:0009836)2.89250481
22Selective tooth agenesis (HP:0001592)2.83001061
23Ulnar bowing (HP:0003031)2.82786378
24Breech presentation (HP:0001623)2.71924873
25Increased nuchal translucency (HP:0010880)2.71358198
26Duplicated collecting system (HP:0000081)2.66744443
27Abnormality of the distal phalanx of the thumb (HP:0009617)2.63189596
28Proximal placement of thumb (HP:0009623)2.60248792
29Aplasia/Hypoplasia of the sacrum (HP:0008517)2.59760237
30Abnormality of chromosome stability (HP:0003220)2.57059387
31Increased hepatocellular lipid droplets (HP:0006565)2.53927512
32Aplasia/Hypoplasia of the uvula (HP:0010293)2.53091737
33Asplenia (HP:0001746)2.52055646
34Macrocytic anemia (HP:0001972)2.49783559
35Abnormal number of incisors (HP:0011064)2.48871457
36Abnormality of the preputium (HP:0100587)2.47704158
37Large earlobe (HP:0009748)2.46424302
38Ragged-red muscle fibers (HP:0003200)2.46092549
39Abnormality of the ileum (HP:0001549)2.45137143
40Meckel diverticulum (HP:0002245)2.44090406
41Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)2.43440645
42Oral leukoplakia (HP:0002745)2.43058324
43Combined immunodeficiency (HP:0005387)2.41971440
44Abnormality of DNA repair (HP:0003254)2.40771471
45Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.39098004
46Duplication of thumb phalanx (HP:0009942)2.36519165
47Flattened epiphyses (HP:0003071)2.33767400
48Facial hemangioma (HP:0000329)2.32961705
49Ependymoma (HP:0002888)2.31555764
50Hypoplasia of the capital femoral epiphysis (HP:0003090)2.31096180
51Aplasia/Hypoplasia of the spleen (HP:0010451)2.30805136
52Horseshoe kidney (HP:0000085)2.30547569
53Septate vagina (HP:0001153)2.28398006
54Insomnia (HP:0100785)2.27920947
55Aplastic anemia (HP:0001915)2.27566664
56Deviation of the thumb (HP:0009603)2.26794979
57Abnormality of cochlea (HP:0000375)2.26126884
58Petechiae (HP:0000967)2.24117755
59Abnormality of the heme biosynthetic pathway (HP:0010472)2.23513840
60Abnormality of the carotid arteries (HP:0005344)2.22882391
61Carpal bone hypoplasia (HP:0001498)2.19289689
62Spinal cord compression (HP:0002176)2.19222546
63Bone marrow hypocellularity (HP:0005528)2.18232932
64Truncus arteriosus (HP:0001660)2.17515010
65Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.17160381
66Vertebral hypoplasia (HP:0008417)2.17160381
67Abnormality of reticulocytes (HP:0004312)2.16468759
68Severe combined immunodeficiency (HP:0004430)2.16319107
69Lymphoma (HP:0002665)2.16157345
70Microretrognathia (HP:0000308)2.15696023
71Abnormality of the renal collecting system (HP:0004742)2.14754529
72Abnormality of the umbilical cord (HP:0010881)2.12668307
73Small intestinal stenosis (HP:0012848)2.11827809
74Duodenal stenosis (HP:0100867)2.11827809
75Cerebral hypomyelination (HP:0006808)2.11679770
76Vertebral clefting (HP:0008428)2.09573976
77Achilles tendon contracture (HP:0001771)2.09188981
78Chronic otitis media (HP:0000389)2.08532263
79Elevated erythrocyte sedimentation rate (HP:0003565)2.08264823
80Flat acetabular roof (HP:0003180)2.07713494
81High anterior hairline (HP:0009890)2.07102728
82Rough bone trabeculation (HP:0100670)2.06913399
83Abnormal vertebral ossification (HP:0100569)2.06447390
84Myelodysplasia (HP:0002863)2.04848581
85Abnormality of the epiphysis of the femoral head (HP:0010574)2.04362357
86Vaginal fistula (HP:0004320)2.03578277
87IgM deficiency (HP:0002850)2.02460377
88Premature graying of hair (HP:0002216)2.02124347
89Lipid accumulation in hepatocytes (HP:0006561)2.02103420
90Absent radius (HP:0003974)2.01493180
91Ectopic kidney (HP:0000086)1.99363936
92Absent thumb (HP:0009777)1.98761568
93Intestinal fistula (HP:0100819)1.98663153
94Rectovaginal fistula (HP:0000143)1.98266215
95Rectal fistula (HP:0100590)1.98266215
96Symphalangism affecting the phalanges of the hand (HP:0009773)1.95267658
97Ureteral duplication (HP:0000073)1.93438871
98Hyperthyroidism (HP:0000836)1.93170277
99Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.92844051
10011 pairs of ribs (HP:0000878)1.92748163
101Entropion (HP:0000621)1.92152547
102Pancytopenia (HP:0001876)1.91717239
103Slender long bone (HP:0003100)1.89579478
104Medulloblastoma (HP:0002885)1.89226123
105Basal cell carcinoma (HP:0002671)1.88624503
106Long palpebral fissure (HP:0000637)1.88056242
107Cholecystitis (HP:0001082)1.88010867
108Abnormal gallbladder physiology (HP:0012438)1.88010867
109Atresia of the external auditory canal (HP:0000413)1.87978479
110Aplasia involving forearm bones (HP:0009822)1.87301730
111Absent forearm bone (HP:0003953)1.87301730
112Short thumb (HP:0009778)1.87031211
113T lymphocytopenia (HP:0005403)1.86907840
114Overriding aorta (HP:0002623)1.86408191
115Renal Fanconi syndrome (HP:0001994)1.85972849
116Trismus (HP:0000211)1.85263366
117Abnormality of femoral epiphyses (HP:0006499)1.84801641
118Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.84801641
119Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.83984824
120Impulsivity (HP:0100710)1.83768106
121Nasal polyposis (HP:0100582)1.83595546
122Abnormality of the femoral head (HP:0003368)1.83222409
123Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.83043828
124Progressive external ophthalmoplegia (HP:0000590)1.82911113
125Agnosia (HP:0010524)1.79743007
126Overlapping toe (HP:0001845)1.78681832
127Aplasia/hypoplasia of the femur (HP:0005613)1.78677547
128Short middle phalanx of finger (HP:0005819)1.78448014
129Facial cleft (HP:0002006)1.78275609
130Reticulocytosis (HP:0001923)1.78223525
131Abnormality of T cells (HP:0002843)1.77865214
132Down-sloping shoulders (HP:0200021)1.77846219
133Absent epiphyses (HP:0010577)1.77658763
134Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.77658763
135Triphalangeal thumb (HP:0001199)1.77627939
136Rib fusion (HP:0000902)1.77397324
137Multiple enchondromatosis (HP:0005701)1.77382463
138Cafe-au-lait spot (HP:0000957)1.77367243
139Abnormal trabecular bone morphology (HP:0100671)1.74025249
140Choanal atresia (HP:0000453)1.71948032
141Morphological abnormality of the inner ear (HP:0011390)1.71797031
142High pitched voice (HP:0001620)1.69378441
143Hypergonadotropic hypogonadism (HP:0000815)1.68951032
144Patellar dislocation (HP:0002999)1.67308238
145Renal duplication (HP:0000075)1.67045624
146Abnormality of the Achilles tendon (HP:0005109)1.66969634
147Abnormality of the calcaneus (HP:0008364)1.64962966
148Myopathic facies (HP:0002058)1.62884014
149Cleft eyelid (HP:0000625)1.62520879
150Elfin facies (HP:0004428)1.60762024
151Self-mutilation (HP:0000742)1.59945063
152Abnormality of the fetal cardiovascular system (HP:0010948)1.59227151
153Single umbilical artery (HP:0001195)1.59227151

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TAOK36.79866622
2CDC74.09165756
3SMG13.75926995
4WEE13.64348477
5VRK23.28168751
6BUB13.18919379
7TRIB33.09606400
8TESK22.53387646
9IRAK32.38916877
10NEK22.28711022
11MAP4K12.23077164
12TTK1.91248912
13NME21.86156170
14VRK11.76456073
15PIM21.75807410
16CDK71.75772972
17ICK1.74738432
18STK161.74354560
19EPHA21.72415820
20EPHB21.72217115
21GRK61.71801939
22SIK11.57770725
23MAP3K101.56943146
24EEF2K1.56395925
25ACVR1B1.53075421
26STK101.50911841
27TLK11.45658079
28PBK1.41274832
29MST1R1.37952168
30TAF11.37356107
31* PLK11.34042697
32AURKB1.32965192
33CLK11.29679537
34BRSK21.29465427
35ATR1.29086830
36EIF2AK11.27731968
37DYRK31.25842673
38ARAF1.24762227
39CHEK21.24128291
40EIF2AK31.19951618
41MAP3K81.17135926
42MST41.15307575
43RPS6KB21.14335696
44STK41.13640934
45BLK1.09522138
46ZAK1.07363855
47CCNB11.06433703
48CDK121.04828488
49PKN21.01740297
50AURKA0.99225271
51PLK40.96984641
52PASK0.95768044
53CDK40.95482840
54BRSK10.95146197
55CHEK10.90678577
56SCYL20.89822193
57PRPF4B0.88552568
58BTK0.87980921
59PIM10.86856305
60UHMK10.85413200
61CDK190.84881661
62TAOK10.84683067
63TAOK20.84597275
64BRAF0.81280319
65CSF1R0.80943604
66MTOR0.80910984
67NME10.80570879
68LRRK20.78072020
69MAPKAPK50.77764676
70SRPK10.76409673
71RPS6KA40.76387379
72PAK10.76252771
73RIPK10.75177469
74MAP3K110.74821588
75ITK0.74330862
76CSNK1G30.74289819
77IRAK20.73135470
78BCKDK0.71961046
79ERN10.69834894
80RAF10.69385826
81NEK10.67800961
82KIT0.66923470
83DAPK10.66776002
84ATM0.64193486
85DYRK20.64109282
86AKT20.63016056
87KDR0.61673580
88PRKD30.58994145
89MELK0.57652147
90MET0.57384695
91CDK80.56061563
92CDK90.55944588
93PAK40.55873910
94MATK0.55847232
95CDK20.55469366
96MKNK10.55088513
97TYK20.55039318
98PTK20.54270845
99TSSK60.52429951
100RPS6KA50.52085607
101CSNK1A1L0.51729178
102TESK10.50288313
103SYK0.49947737
104CDK11A0.49703879
105BMX0.48575224
106TTN0.48045068
107MAP2K30.47565715
108CDK150.47310213
109PLK30.46983781
110ABL20.46678550
111MAP3K90.46244809
112ILK0.45851069
113CSNK2A20.45714405
114KSR20.44645375
115CDK10.43526667
116LCK0.42912971
117CDK180.41932287
118LYN0.41325992
119STK390.40286937
120LIMK10.39707620
121CSNK2A10.39483030
122MAP2K20.38939723
123CDK140.38834923
124ZAP700.38113973
125PRKCI0.37071598
126HIPK20.36639029
127MAPK110.36596193
128CSK0.36014336
129CSNK1G10.35830648
130MAPKAPK20.35786905
131CDK60.33819522
132IRAK40.33330887
133MUSK0.30820503
134RPS6KA10.30393571

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030306.21643518
2Mismatch repair_Homo sapiens_hsa034304.71506158
3Ribosome_Homo sapiens_hsa030103.48094486
4Base excision repair_Homo sapiens_hsa034103.42571180
5Homologous recombination_Homo sapiens_hsa034403.28570740
6Nucleotide excision repair_Homo sapiens_hsa034202.80252081
7* Cell cycle_Homo sapiens_hsa041102.75577227
8RNA polymerase_Homo sapiens_hsa030202.69889420
9Spliceosome_Homo sapiens_hsa030402.65298832
10Pyrimidine metabolism_Homo sapiens_hsa002402.40249601
11Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.38238120
12Fanconi anemia pathway_Homo sapiens_hsa034602.29423876
13Proteasome_Homo sapiens_hsa030502.13765543
14RNA transport_Homo sapiens_hsa030132.04963716
15One carbon pool by folate_Homo sapiens_hsa006701.95464809
16Non-homologous end-joining_Homo sapiens_hsa034501.84107594
17p53 signaling pathway_Homo sapiens_hsa041151.75269379
182-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.63284677
19RNA degradation_Homo sapiens_hsa030181.49750412
20Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.46065262
21Primary immunodeficiency_Homo sapiens_hsa053401.43637731
22Basal transcription factors_Homo sapiens_hsa030221.39083638
23Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.27498476
24Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.26777246
25Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.26598652
26Fructose and mannose metabolism_Homo sapiens_hsa000511.23449865
27Carbon metabolism_Homo sapiens_hsa012001.16635859
28Purine metabolism_Homo sapiens_hsa002301.08783406
29Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.07713052
30mRNA surveillance pathway_Homo sapiens_hsa030151.07691811
31Central carbon metabolism in cancer_Homo sapiens_hsa052301.04634288
32Epstein-Barr virus infection_Homo sapiens_hsa051691.00148635
33Systemic lupus erythematosus_Homo sapiens_hsa053220.99214454
34Pentose phosphate pathway_Homo sapiens_hsa000300.98118392
35Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.97579711
36Oxidative phosphorylation_Homo sapiens_hsa001900.95981910
37Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.93835982
38Parkinsons disease_Homo sapiens_hsa050120.91931831
39Galactose metabolism_Homo sapiens_hsa000520.91323881
40Antigen processing and presentation_Homo sapiens_hsa046120.89286715
41Pyruvate metabolism_Homo sapiens_hsa006200.88897212
42Protein export_Homo sapiens_hsa030600.88808485
43Herpes simplex infection_Homo sapiens_hsa051680.87690880
44Thyroid cancer_Homo sapiens_hsa052160.86990018
45Viral carcinogenesis_Homo sapiens_hsa052030.84670029
46Folate biosynthesis_Homo sapiens_hsa007900.83489375
47Lysine degradation_Homo sapiens_hsa003100.81765124
48Huntingtons disease_Homo sapiens_hsa050160.79910907
49Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.78001535
50Apoptosis_Homo sapiens_hsa042100.77793781
51Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.77561147
52Vitamin B6 metabolism_Homo sapiens_hsa007500.76812268
53Hematopoietic cell lineage_Homo sapiens_hsa046400.72854217
54Chronic myeloid leukemia_Homo sapiens_hsa052200.72514051
55Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.71946317
56Small cell lung cancer_Homo sapiens_hsa052220.70408980
57HTLV-I infection_Homo sapiens_hsa051660.68679955
58B cell receptor signaling pathway_Homo sapiens_hsa046620.68246990
59Selenocompound metabolism_Homo sapiens_hsa004500.65862804
60Shigellosis_Homo sapiens_hsa051310.65696996
61Glutathione metabolism_Homo sapiens_hsa004800.64865449
62NF-kappa B signaling pathway_Homo sapiens_hsa040640.64683253
63T cell receptor signaling pathway_Homo sapiens_hsa046600.64382210
64Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.63500990
65Measles_Homo sapiens_hsa051620.62341059
66Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.61813940
67Sulfur relay system_Homo sapiens_hsa041220.61598216
68Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.59132040
69Cyanoamino acid metabolism_Homo sapiens_hsa004600.58217248
70Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.57692883
71Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.55343196
72Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.54531080
73Alzheimers disease_Homo sapiens_hsa050100.54366431
74Hepatitis B_Homo sapiens_hsa051610.54251023
75Basal cell carcinoma_Homo sapiens_hsa052170.53912856
76Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.53538323
77Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.52634259
78Acute myeloid leukemia_Homo sapiens_hsa052210.51062289
79* Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.50879329
80Pancreatic cancer_Homo sapiens_hsa052120.50768492
81* Oocyte meiosis_Homo sapiens_hsa041140.50439083
82Steroid biosynthesis_Homo sapiens_hsa001000.49401909
83Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.46419800
84Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.45792815
85Colorectal cancer_Homo sapiens_hsa052100.45323608
86Transcriptional misregulation in cancer_Homo sapiens_hsa052020.45197779
87Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.45180366
88Melanoma_Homo sapiens_hsa052180.44711638
89MicroRNAs in cancer_Homo sapiens_hsa052060.44605339
90N-Glycan biosynthesis_Homo sapiens_hsa005100.42351780
91Leukocyte transendothelial migration_Homo sapiens_hsa046700.41851583
92Prostate cancer_Homo sapiens_hsa052150.40763543
93Alcoholism_Homo sapiens_hsa050340.40139004
94Hippo signaling pathway_Homo sapiens_hsa043900.39968274
95Glioma_Homo sapiens_hsa052140.35384556
96Non-small cell lung cancer_Homo sapiens_hsa052230.35146620
97Linoleic acid metabolism_Homo sapiens_hsa005910.34093330
98Graft-versus-host disease_Homo sapiens_hsa053320.33796859
99Drug metabolism - other enzymes_Homo sapiens_hsa009830.33435751
100Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.32339430
101Legionellosis_Homo sapiens_hsa051340.30034841
102Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.29895226
103Leishmaniasis_Homo sapiens_hsa051400.29784224
104Asthma_Homo sapiens_hsa053100.28498721
105Jak-STAT signaling pathway_Homo sapiens_hsa046300.28107092
106Endometrial cancer_Homo sapiens_hsa052130.27527039
107Cysteine and methionine metabolism_Homo sapiens_hsa002700.27520419
108Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.26671762
109Bladder cancer_Homo sapiens_hsa052190.26618891
110VEGF signaling pathway_Homo sapiens_hsa043700.26500848
111Ether lipid metabolism_Homo sapiens_hsa005650.26169612
112RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.25213247
113Intestinal immune network for IgA production_Homo sapiens_hsa046720.25100260
114Pathways in cancer_Homo sapiens_hsa052000.24476136
115AMPK signaling pathway_Homo sapiens_hsa041520.23502349
116Arginine and proline metabolism_Homo sapiens_hsa003300.23470900
117Thyroid hormone signaling pathway_Homo sapiens_hsa049190.23283401
118Vibrio cholerae infection_Homo sapiens_hsa051100.22716299
119Renin-angiotensin system_Homo sapiens_hsa046140.22307615
120Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.22274221
121Viral myocarditis_Homo sapiens_hsa054160.22078111
122Biosynthesis of amino acids_Homo sapiens_hsa012300.22051190
123Fatty acid elongation_Homo sapiens_hsa000620.21703265
124Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.21505112
125Metabolic pathways_Homo sapiens_hsa011000.21137246
126Notch signaling pathway_Homo sapiens_hsa043300.20399314
127Allograft rejection_Homo sapiens_hsa053300.19488989
128Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.18862117
129Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.18856662

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