PKN2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)5.60484533
2histone H3-K4 trimethylation (GO:0080182)5.43714797
3nuclear pore organization (GO:0006999)5.15257060
4protein K11-linked deubiquitination (GO:0035871)5.04399225
5rRNA catabolic process (GO:0016075)4.95799895
6UDP-N-acetylglucosamine metabolic process (GO:0006047)4.57535232
7interkinetic nuclear migration (GO:0022027)4.55488085
8peptidyl-lysine trimethylation (GO:0018023)4.45195234
9Golgi to endosome transport (GO:0006895)4.35983304
10positive regulation of DNA-templated transcription, initiation (GO:2000144)4.28922987
11peptidyl-threonine dephosphorylation (GO:0035970)4.12727444
12mitotic sister chromatid cohesion (GO:0007064)4.10941493
13mitotic chromosome condensation (GO:0007076)3.96641967
14interleukin-6-mediated signaling pathway (GO:0070102)3.93237321
15pore complex assembly (GO:0046931)3.93111865
16positive regulation of histone H3-K4 methylation (GO:0051571)3.91402773
17phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.86797417
18regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.75072130
19monoubiquitinated protein deubiquitination (GO:0035520)3.59264448
20protein localization to kinetochore (GO:0034501)3.45528582
21regulation of RNA export from nucleus (GO:0046831)3.43608251
22snRNA processing (GO:0016180)3.43160259
23regulation of histone H3-K9 methylation (GO:0051570)3.41826111
24mitotic metaphase plate congression (GO:0007080)3.37077575
25positive regulation of mitotic sister chromatid separation (GO:1901970)3.33598495
26positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.33598495
27positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.33598495
28centriole replication (GO:0007099)3.32709302
29protein K48-linked deubiquitination (GO:0071108)3.32533859
30negative regulation of complement activation (GO:0045916)3.30874728
31kinetochore organization (GO:0051383)3.29411183
32definitive hemopoiesis (GO:0060216)3.29101916
33reciprocal DNA recombination (GO:0035825)3.28938865
34reciprocal meiotic recombination (GO:0007131)3.28938865
35regulation of MHC class II biosynthetic process (GO:0045346)3.26595805
36metaphase plate congression (GO:0051310)3.26418464
37mitotic nuclear envelope disassembly (GO:0007077)3.24975868
38regulation of spindle organization (GO:0090224)3.24905174
39mitotic G2/M transition checkpoint (GO:0044818)3.21553738
40sister chromatid segregation (GO:0000819)3.20712778
41regulation of mitotic spindle organization (GO:0060236)3.18263167
42bundle of His cell to Purkinje myocyte communication (GO:0086069)3.18104889
43chromatin assembly (GO:0031497)3.15505171
44positive regulation of transcription initiation from RNA polymerase II promoter (GO:0060261)3.14015360
45retrograde transport, vesicle recycling within Golgi (GO:0000301)3.10752746
46regulation of sister chromatid cohesion (GO:0007063)3.10395277
47membrane disassembly (GO:0030397)3.08934308
48nuclear envelope disassembly (GO:0051081)3.08934308
49regulation of transforming growth factor beta2 production (GO:0032909)3.08404019
50paraxial mesoderm development (GO:0048339)3.07407304
51snRNA metabolic process (GO:0016073)3.05411953
52pre-miRNA processing (GO:0031054)3.05173792
53protein localization to chromosome, centromeric region (GO:0071459)3.00991198
54establishment of protein localization to Golgi (GO:0072600)3.00873606
55pericardium development (GO:0060039)2.99576676
56histone H3-K4 methylation (GO:0051568)2.99379288
57ncRNA catabolic process (GO:0034661)2.98693592
58mitotic G2 DNA damage checkpoint (GO:0007095)2.98541223
59DNA unwinding involved in DNA replication (GO:0006268)2.97314043
60peptidyl-lysine methylation (GO:0018022)2.95909215
61positive regulation of histone methylation (GO:0031062)2.95866776
62regulation of centriole replication (GO:0046599)2.95196946
63regulation of DNA damage checkpoint (GO:2000001)2.93888609
64histone H3-K36 demethylation (GO:0070544)2.93841528
65protein targeting to Golgi (GO:0000042)2.92618853
66positive regulation of chromosome segregation (GO:0051984)2.91247257
67negative regulation of protein activation cascade (GO:2000258)2.91064058
68regulation of gene silencing by RNA (GO:0060966)2.86859923
69regulation of posttranscriptional gene silencing (GO:0060147)2.86859923
70regulation of gene silencing by miRNA (GO:0060964)2.86859923
71acrosome assembly (GO:0001675)2.86331426
72negative regulation of histone methylation (GO:0031061)2.84086270
73histone H2A monoubiquitination (GO:0035518)2.83861203
74DNA replication-dependent nucleosome assembly (GO:0006335)2.81619134
75DNA replication-dependent nucleosome organization (GO:0034723)2.81619134
76folic acid-containing compound biosynthetic process (GO:0009396)2.79434183
77regulation of histone H3-K4 methylation (GO:0051569)2.77789799
78regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.76783714
79mitotic sister chromatid segregation (GO:0000070)2.75779187
80mitochondrion degradation (GO:0000422)2.75190903
81detection of molecule of bacterial origin (GO:0032490)2.74536407
82negative regulation of NF-kappaB import into nucleus (GO:0042347)2.73790347
83DNA duplex unwinding (GO:0032508)2.73355069
84cytoplasmic mRNA processing body assembly (GO:0033962)2.73124359
85response to UV-C (GO:0010225)2.72087657
86histone H3-K9 demethylation (GO:0033169)2.71371301
87DNA geometric change (GO:0032392)2.71256604
88hippo signaling (GO:0035329)2.69974162
89heterochromatin organization (GO:0070828)2.69973675
90positive regulation of SMAD protein import into nucleus (GO:0060391)2.69777132
91pathway-restricted SMAD protein phosphorylation (GO:0060389)2.69086980
92neural tube formation (GO:0001841)2.68237034
93toxin transport (GO:1901998)2.67258452
94regulation of histone H3-K27 methylation (GO:0061085)2.66386202
95dosage compensation (GO:0007549)2.66136908
96regulation of centrosome cycle (GO:0046605)2.65068391
97chromosome condensation (GO:0030261)2.64362389
98embryonic process involved in female pregnancy (GO:0060136)2.64132667
99cellular response to ethanol (GO:0071361)2.64053654
100establishment of chromosome localization (GO:0051303)2.62998878
101granulocyte differentiation (GO:0030851)2.62704784
102regulation of nucleobase-containing compound transport (GO:0032239)2.62391551
103positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.61190042
104regulation of establishment of cell polarity (GO:2000114)2.61088703
105histone H4-K16 acetylation (GO:0043984)2.60488045
106negative regulation of DNA repair (GO:0045738)2.60208402
107early endosome to late endosome transport (GO:0045022)2.60198187
108DNA replication initiation (GO:0006270)2.59515481
109meiotic chromosome segregation (GO:0045132)2.57866139
110hypotonic response (GO:0006971)2.57515358
111negative regulation of neurotransmitter secretion (GO:0046929)2.56130604
112protein K63-linked deubiquitination (GO:0070536)2.56117912
113kinetochore assembly (GO:0051382)2.54791470
114chromatin assembly or disassembly (GO:0006333)2.53670911
115regulation of SMAD protein import into nucleus (GO:0060390)2.53636901
116hepatocyte differentiation (GO:0070365)2.52651134
117regulation of DNA endoreduplication (GO:0032875)2.52404029
118peptidyl-lysine dimethylation (GO:0018027)2.51960404
119N-terminal protein amino acid modification (GO:0031365)2.51595586
120protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)2.50155211
121protein localization to chromosome (GO:0034502)2.49969910
122regulation of hippo signaling (GO:0035330)2.49272127
123morphogenesis of an epithelial sheet (GO:0002011)2.48572718
124regulation of helicase activity (GO:0051095)2.46166535
125regulation of chromosome segregation (GO:0051983)2.45891277
126regulation of histone methylation (GO:0031060)2.44713716
127histone mRNA catabolic process (GO:0071044)2.44146740
128regulation of centrosome duplication (GO:0010824)2.43928536
129RNA stabilization (GO:0043489)2.43818944
130mRNA stabilization (GO:0048255)2.43818944
131spindle assembly involved in mitosis (GO:0090307)2.43625545
132nuclear envelope organization (GO:0006998)2.43430910
133regulation of mitotic metaphase/anaphase transition (GO:0030071)2.43416973
134replicative senescence (GO:0090399)2.43386031
135spindle checkpoint (GO:0031577)2.42844105
136positive regulation of cell cycle checkpoint (GO:1901978)2.42509561
137snRNA transcription (GO:0009301)2.42477622
138histone lysine methylation (GO:0034968)2.42345480
139regulation of DNA-templated transcription, initiation (GO:2000142)2.41955481
140regulation of protein polyubiquitination (GO:1902914)2.41262749
141regulation of double-strand break repair (GO:2000779)2.40585122
142hepatocyte apoptotic process (GO:0097284)2.39460947
143negative regulation of glycoprotein biosynthetic process (GO:0010561)2.39333928
144chromatin remodeling at centromere (GO:0031055)2.39188022
145histone H2B ubiquitination (GO:0033523)2.38964959
146negative regulation of humoral immune response (GO:0002921)2.38133990
147regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.37598552
148DNA conformation change (GO:0071103)2.37584425
149DNA topological change (GO:0006265)2.37480118
150IMP biosynthetic process (GO:0006188)2.37038893
151NLS-bearing protein import into nucleus (GO:0006607)2.35179811
152DNA packaging (GO:0006323)2.33654547
153histone-serine phosphorylation (GO:0035404)2.33095264
154notochord development (GO:0030903)2.31611892
155CENP-A containing nucleosome assembly (GO:0034080)2.29235653
156gene silencing by RNA (GO:0031047)2.28763789
157regulation of translational fidelity (GO:0006450)2.26235045
158histone lysine demethylation (GO:0070076)2.26091288
159sister chromatid cohesion (GO:0007062)2.25802391
160microtubule cytoskeleton organization involved in mitosis (GO:1902850)2.25415804
161mitotic spindle checkpoint (GO:0071174)2.24768365
162spindle assembly checkpoint (GO:0071173)2.24153379
163regulation of mitotic sister chromatid separation (GO:0010965)2.23116428
164regulation of mitotic sister chromatid segregation (GO:0033047)2.23116428
165regulation of sister chromatid segregation (GO:0033045)2.23116428
166protein K6-linked ubiquitination (GO:0085020)2.22252895
167histone demethylation (GO:0016577)2.21395684
168regulation of gene silencing (GO:0060968)2.21250786
169DNA replication-independent nucleosome organization (GO:0034724)2.20552754
170DNA replication-independent nucleosome assembly (GO:0006336)2.20552754
171iron ion import (GO:0097286)2.19889216

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.53187587
2FOXM1_23109430_ChIP-Seq_U2OS_Human5.24218145
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.46444891
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.56115462
5EGR1_19374776_ChIP-ChIP_THP-1_Human3.29078023
6SALL1_21062744_ChIP-ChIP_HESCs_Human3.06166744
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.91978936
8AR_21909140_ChIP-Seq_LNCAP_Human2.83911962
9NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.81365376
10* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.80646276
11POU3F2_20337985_ChIP-ChIP_501MEL_Human2.79503340
12TP63_17297297_ChIP-ChIP_HaCaT_Human2.45566844
13HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.14602394
14* E2F1_21310950_ChIP-Seq_MCF-7_Human2.10514637
15FUS_26573619_Chip-Seq_HEK293_Human2.04156306
16STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.97687077
17RBPJ_22232070_ChIP-Seq_NCS_Mouse1.97187491
18MYC_18555785_ChIP-Seq_MESCs_Mouse1.96425316
19* EWS_26573619_Chip-Seq_HEK293_Human1.86895638
20CLOCK_20551151_ChIP-Seq_293T_Human1.82175786
21AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.79664821
22TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.76422964
23NELFA_20434984_ChIP-Seq_ESCs_Mouse1.75235154
24HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.71015603
25FOXM1_26456572_ChIP-Seq_MCF-7_Human1.67352491
26SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.66076864
27TAF15_26573619_Chip-Seq_HEK293_Human1.61640747
28SMAD_19615063_ChIP-ChIP_OVARY_Human1.61101250
29* TCF4_18268006_ChIP-ChIP_LS174T_Human1.59440899
30CDX2_19796622_ChIP-Seq_MESCs_Mouse1.58138980
31SALL4_18804426_ChIP-ChIP_XEN_Mouse1.57189973
32SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.56702317
33* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.56006498
34IGF1R_20145208_ChIP-Seq_DFB_Human1.52587711
35MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.52418725
36FLI1_27457419_Chip-Seq_LIVER_Mouse1.51810199
37HIF1A_21447827_ChIP-Seq_MCF-7_Human1.49984688
38TP53_16413492_ChIP-PET_HCT116_Human1.48953955
39GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.48428483
40ZNF217_24962896_ChIP-Seq_MCF-7_Human1.46038989
41MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.45444107
42MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.44531109
43ESR1_20079471_ChIP-ChIP_T-47D_Human1.44483311
44ELK1_19687146_ChIP-ChIP_HELA_Human1.43757259
45CDX2_22108803_ChIP-Seq_LS180_Human1.41358802
46CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.39998516
47SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.39413599
48FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.36173822
49SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.35872572
50SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.35872572
51TCF3_18692474_ChIP-Seq_MEFs_Mouse1.34542667
52PIAS1_25552417_ChIP-Seq_VCAP_Human1.34250104
53MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.34217730
54* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.34186198
55MYC_19079543_ChIP-ChIP_MESCs_Mouse1.33621990
56TP63_19390658_ChIP-ChIP_HaCaT_Human1.32496731
57CJUN_26792858_Chip-Seq_BT549_Human1.31498625
58PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.30096434
59ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.29896811
60STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.29611484
61MYC_19030024_ChIP-ChIP_MESCs_Mouse1.29594737
62RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.29467288
63PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.28633768
64BRD4_25478319_ChIP-Seq_HGPS_Human1.27719849
65ER_23166858_ChIP-Seq_MCF-7_Human1.27368148
66FOXO3_23340844_ChIP-Seq_DLD1_Human1.26630095
67Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.24829589
68ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.24711534
69* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.24560247
70EGR1_23403033_ChIP-Seq_LIVER_Mouse1.24408956
71EZH2_27294783_Chip-Seq_NPCs_Mouse1.22538037
72TCF4_23295773_ChIP-Seq_U87_Human1.21995656
73FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.21672212
74STAT3_23295773_ChIP-Seq_U87_Human1.20269520
75* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.19244644
76ZFP57_27257070_Chip-Seq_ESCs_Mouse1.18893156
77MYCN_18555785_ChIP-Seq_MESCs_Mouse1.18883694
78TCF3_18692474_ChIP-Seq_MESCs_Mouse1.18169753
79RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.17394112
80* TP63_23658742_ChIP-Seq_EP156T_Human1.16876344
81* SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.15836053
82STAT3_1855785_ChIP-Seq_MESCs_Mouse1.14902007
83FOXA1_25552417_ChIP-Seq_VCAP_Human1.14545058
84* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.14518323
85SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.14127691
86CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.13365149
87CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.12488484
88AHR_22903824_ChIP-Seq_MCF-7_Human1.12192378
89P300_19829295_ChIP-Seq_ESCs_Human1.12191371
90TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.11184758
91* CHD1_26751641_Chip-Seq_LNCaP_Human1.09819839
92BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.09153021
93PCGF2_27294783_Chip-Seq_ESCs_Mouse1.08448430
94ZNF263_19887448_ChIP-Seq_K562_Human1.08274166
95PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.08231114
96GATA6_25053715_ChIP-Seq_YYC3_Human1.07368322
97MYB_21317192_ChIP-Seq_ERMYB_Mouse1.06921651
98ESR1_15608294_ChIP-ChIP_MCF-7_Human1.06534306
99FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.06510700
100NRF2_20460467_ChIP-Seq_MEFs_Mouse1.06207279
101NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.06207279
102GATA1_22025678_ChIP-Seq_K562_Human1.06116646
103* ARNT_22903824_ChIP-Seq_MCF-7_Human1.06085958
104POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.06060195
105* EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.05829701
106FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.05294738
107* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.05147512
108SMAD4_21799915_ChIP-Seq_A2780_Human1.05099852
109* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.05039449
110PCGF2_27294783_Chip-Seq_NPCs_Mouse1.04531050
111NR3C1_21868756_ChIP-Seq_MCF10A_Human1.04482682
112CBP_20019798_ChIP-Seq_JUKART_Human1.04311559
113IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.04311559
114OCT4_21477851_ChIP-Seq_ESCs_Mouse1.03615904
115CTNNB1_20460455_ChIP-Seq_HCT116_Human1.02229867
116E2F1_18555785_Chip-Seq_ESCs_Mouse1.01314424
117WT1_19549856_ChIP-ChIP_CCG9911_Human1.01282896
118SOX2_18555785_ChIP-Seq_MESCs_Mouse1.00868864
119* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.00675990
120* ZFX_18555785_ChIP-Seq_MESCs_Mouse0.99662654
121SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.99069202
122TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.98576591
123MYC_22102868_ChIP-Seq_BL_Human0.98250310
124KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.97020585
125KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.97020585
126KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.97020585
127NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.96945586
128EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.96523968
129FLI1_21867929_ChIP-Seq_TH2_Mouse0.95970284
130* NANOG_18555785_Chip-Seq_ESCs_Mouse0.95644116
131NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.95394691
132* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.95289578
133CRX_20693478_ChIP-Seq_RETINA_Mouse0.95043134
134* CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.94967817
135* TFEB_21752829_ChIP-Seq_HELA_Human0.94949149
136ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.94678883
137AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.94199924
138NANOG_18555785_ChIP-Seq_MESCs_Mouse0.93479292
139NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.90573151
140ATF3_27146783_Chip-Seq_COLON_Human0.89551878
141* KLF4_18555785_ChIP-Seq_MESCs_Mouse0.89288475
142LXR_22158963_ChIP-Seq_LIVER_Mouse0.87774130
143KDM5A_27292631_Chip-Seq_BREAST_Human0.87590453
144TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.87557394
145* GATA4_25053715_ChIP-Seq_YYC3_Human0.87037303
146* TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.86820366
147* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.86412460
148NANOG_21062744_ChIP-ChIP_HESCs_Human0.86100875
149UBF1/2_26484160_Chip-Seq_HMECs_Human0.85382692
150SOX2_27498859_Chip-Seq_STOMACH_Mouse0.83542632
151CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.83169889
152PPARA_22158963_ChIP-Seq_LIVER_Mouse0.82865657
153RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.82696713
154* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.82359952
155ESR1_21235772_ChIP-Seq_MCF-7_Human0.82279885
156HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.81433862
157FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.80782888
158* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.80520465
159CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.80170583
160TRIM28_21343339_ChIP-Seq_HEK293_Human0.79806931
161POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.79034716
162NCOR1_26117541_ChIP-Seq_K562_Human0.76674539
163NANOG_16153702_ChIP-ChIP_HESCs_Human0.75980492

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation3.37929249
2MP0003705_abnormal_hypodermis_morpholog3.12352800
3MP0008438_abnormal_cutaneous_collagen2.74762664
4MP0010352_gastrointestinal_tract_polyps2.69105477
5MP0003693_abnormal_embryo_hatching2.18781610
6MP0010307_abnormal_tumor_latency2.16811760
7MP0010094_abnormal_chromosome_stability2.09835669
8MP0005076_abnormal_cell_differentiation2.03656736
9MP0010234_abnormal_vibrissa_follicle2.01567796
10MP0005409_darkened_coat_color1.98798604
11MP0005085_abnormal_gallbladder_physiolo1.98613165
12MP0003111_abnormal_nucleus_morphology1.97864738
13MP0008057_abnormal_DNA_replication1.96198799
14MP0004484_altered_response_of1.94695026
15MP0004957_abnormal_blastocyst_morpholog1.94537046
16MP0003077_abnormal_cell_cycle1.94511255
17MP0005310_abnormal_salivary_gland1.73929933
18MP0004272_abnormal_basement_membrane1.73772424
19MP0005275_abnormal_skin_tensile1.73471403
20MP0000537_abnormal_urethra_morphology1.66791357
21MP0009053_abnormal_anal_canal1.65517797
22MP0003566_abnormal_cell_adhesion1.62222001
23MP0006054_spinal_hemorrhage1.62132662
24MP0002877_abnormal_melanocyte_morpholog1.61324833
25MP0004197_abnormal_fetal_growth/weight/1.54911014
26MP0010678_abnormal_skin_adnexa1.51627052
27MP0003221_abnormal_cardiomyocyte_apopto1.49747906
28MP0002086_abnormal_extraembryonic_tissu1.46369753
29MP0001730_embryonic_growth_arrest1.44787996
30MP0000383_abnormal_hair_follicle1.40345508
31MP0005380_embryogenesis_phenotype1.39863575
32MP0001672_abnormal_embryogenesis/_devel1.39863575
33MP0008007_abnormal_cellular_replicative1.37216700
34MP0003937_abnormal_limbs/digits/tail_de1.36120343
35MP0002088_abnormal_embryonic_growth/wei1.35741544
36MP0003984_embryonic_growth_retardation1.35452036
37MP0000350_abnormal_cell_proliferation1.35439358
38MP0009384_cardiac_valve_regurgitation1.34381245
39MP0005623_abnormal_meninges_morphology1.34008215
40MP0002084_abnormal_developmental_patter1.33461915
41MP0003300_gastrointestinal_ulcer1.30411447
42MP0003567_abnormal_fetal_cardiomyocyte1.30133990
43MP0004185_abnormal_adipocyte_glucose1.27021258
44MP0003252_abnormal_bile_duct1.24591610
45MP0003123_paternal_imprinting1.24549007
46MP0001697_abnormal_embryo_size1.24056515
47MP0004264_abnormal_extraembryonic_tissu1.23000628
48MP0002060_abnormal_skin_morphology1.22662171
49MP0005023_abnormal_wound_healing1.21964868
50MP0000733_abnormal_muscle_development1.21537576
51MP0002085_abnormal_embryonic_tissue1.19551379
52MP0002928_abnormal_bile_duct1.19171733
53MP0003950_abnormal_plasma_membrane1.18730879
54MP0003941_abnormal_skin_development1.18556435
55MP0001293_anophthalmia1.12311037
56MP0005164_abnormal_response_to1.10930801
57MP0005503_abnormal_tendon_morphology1.10626828
58MP0003453_abnormal_keratinocyte_physiol1.09893435
59MP0003091_abnormal_cell_migration1.07919717
60MP0004233_abnormal_muscle_weight1.06705678
61MP0004782_abnormal_surfactant_physiolog1.06005662
62MP0002092_abnormal_eye_morphology1.05958685
63MP0002009_preneoplasia1.05123698
64MP0009780_abnormal_chondrocyte_physiolo1.05122313
65MP0002697_abnormal_eye_size1.04150435
66MP0003183_abnormal_peptide_metabolism1.03854343
67MP0008932_abnormal_embryonic_tissue1.03469120
68MP0005360_urolithiasis1.01753863
69MP0010030_abnormal_orbit_morphology1.01069179
70MP0005666_abnormal_adipose_tissue1.00101217
71MP0003890_abnormal_embryonic-extraembry0.99354737
72MP0005367_renal/urinary_system_phenotyp0.98530496
73MP0000516_abnormal_urinary_system0.98530496
74MP0000015_abnormal_ear_pigmentation0.98071508
75MP0000432_abnormal_head_morphology0.97981244
76MP0004808_abnormal_hematopoietic_stem0.97742832
77MP0002282_abnormal_trachea_morphology0.96764951
78MP0005248_abnormal_Harderian_gland0.96107755
79MP0004883_abnormal_blood_vessel0.95607461
80MP0005187_abnormal_penis_morphology0.95459377
81MP0002080_prenatal_lethality0.95261316
82MP0003786_premature_aging0.93759638
83MP0003121_genomic_imprinting0.93273366
84MP0003828_pulmonary_edema0.93238154
85MP0003935_abnormal_craniofacial_develop0.90222486
86MP0002925_abnormal_cardiovascular_devel0.89817428
87MP0003656_abnormal_erythrocyte_physiolo0.89763002
88MP0002098_abnormal_vibrissa_morphology0.88982415
89MP0005174_abnormal_tail_pigmentation0.88719103
90MP0009697_abnormal_copulation0.88514055
91MP0003115_abnormal_respiratory_system0.88106025
92MP0001915_intracranial_hemorrhage0.88020772
93MP0008058_abnormal_DNA_repair0.87177497
94MP0005376_homeostasis/metabolism_phenot0.86700781
95MP0003943_abnormal_hepatobiliary_system0.85996214
96MP0002166_altered_tumor_susceptibility0.85457842
97MP0000767_abnormal_smooth_muscle0.85306912
98MP0000428_abnormal_craniofacial_morphol0.84888529
99MP0002006_tumorigenesis0.84438473
100MP0000647_abnormal_sebaceous_gland0.83577877
101MP0005408_hypopigmentation0.82481470
102MP0001849_ear_inflammation0.82235093
103MP0000490_abnormal_crypts_of0.82188386
104MP0009703_decreased_birth_body0.82113282
105MP0002971_abnormal_brown_adipose0.81483803
106MP0002396_abnormal_hematopoietic_system0.81173162
107MP0005508_abnormal_skeleton_morphology0.79784212
108MP0001186_pigmentation_phenotype0.78875396
109MP0000427_abnormal_hair_cycle0.78864233
110MP0001666_abnormal_nutrient_absorption0.78647071
111MP0002111_abnormal_tail_morphology0.78367223
112MP0002254_reproductive_system_inflammat0.77499994
113MP0004084_abnormal_cardiac_muscle0.77481840
114MP0001243_abnormal_dermal_layer0.76766722
115MP0010368_abnormal_lymphatic_system0.76730142
116MP0000627_abnormal_mammary_gland0.75100580
117MP0001216_abnormal_epidermal_layer0.74891300
118MP0006138_congestive_heart_failure0.74881479
119MP0001784_abnormal_fluid_regulation0.74536531
120MP0003119_abnormal_digestive_system0.74363147
121MP0005220_abnormal_exocrine_pancreas0.73969541
122MP0008877_abnormal_DNA_methylation0.73746779
123MP0005501_abnormal_skin_physiology0.73508767
124MP0001191_abnormal_skin_condition0.73066511
125MP0002138_abnormal_hepatobiliary_system0.71946007
126MP0000377_abnormal_hair_follicle0.71695902
127MP0002796_impaired_skin_barrier0.71412651
128MP0010630_abnormal_cardiac_muscle0.71144685
129MP0002168_other_aberrant_phenotype0.70888349
130MP0001286_abnormal_eye_development0.70824606
131MP0003045_fibrosis0.70455582
132MP0005621_abnormal_cell_physiology0.70157822
133MP0003755_abnormal_palate_morphology0.69909021
134MP0002896_abnormal_bone_mineralization0.69804560
135MP0005375_adipose_tissue_phenotype0.69500894
136MP0003385_abnormal_body_wall0.67313828
137MP0001879_abnormal_lymphatic_vessel0.67197049
138MP0009278_abnormal_bone_marrow0.66840444
139MP0003868_abnormal_feces_composition0.66663262
140MP0004043_abnormal_pH_regulation0.66193335
141MP0009672_abnormal_birth_weight0.66171383

Predicted human phenotypes

RankGene SetZ-score
1Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.85432401
2Rectal prolapse (HP:0002035)2.78497296
3Ankle contracture (HP:0006466)2.78432205
4Hematochezia (HP:0002573)2.66986679
5Volvulus (HP:0002580)2.64053441
6Premature rupture of membranes (HP:0001788)2.61364522
7Abnormality of the parietal bone (HP:0002696)2.55490781
8Short 4th metacarpal (HP:0010044)2.54103618
9Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.54103618
10Deviation of the thumb (HP:0009603)2.52243620
11Subacute progressive viral hepatitis (HP:0006572)2.51874814
12Selective tooth agenesis (HP:0001592)2.49423946
13Chromsome breakage (HP:0040012)2.47518904
14Low anterior hairline (HP:0000294)2.45127284
15Colon cancer (HP:0003003)2.43498444
16Arterial tortuosity (HP:0005116)2.38663200
17Aplasia cutis congenita (HP:0001057)2.36152341
18Protrusio acetabuli (HP:0003179)2.32602941
19Biliary tract neoplasm (HP:0100574)2.31538076
20Shallow orbits (HP:0000586)2.30781623
21Proximal placement of thumb (HP:0009623)2.26264935
22Capillary hemangiomas (HP:0005306)2.24741814
23Lip pit (HP:0100267)2.22950475
24Midline defect of the nose (HP:0004122)2.20236770
25Missing ribs (HP:0000921)2.17029118
26Hereditary nonpolyposis colorectal carcinoma (HP:0006716)2.16799132
27Abnormality of the ischium (HP:0003174)2.15730420
28Abnormality of chromosome stability (HP:0003220)2.14614975
29Right ventricular cardiomyopathy (HP:0011663)2.14173878
30Aortic aneurysm (HP:0004942)2.13202049
31Transitional cell carcinoma of the bladder (HP:0006740)2.12722698
32Hypoplastic ischia (HP:0003175)2.11244585
33Curly hair (HP:0002212)2.10024687
34Abnormality of the labia majora (HP:0012881)2.09825529
35Osteolytic defects of the phalanges of the hand (HP:0009771)2.09253005
36Osteolytic defects of the hand bones (HP:0009699)2.09253005
37Cystic hygroma (HP:0000476)2.09096805
38Chromosomal breakage induced by crosslinking agents (HP:0003221)2.08489559
39Bladder carcinoma (HP:0002862)2.07890738
40Bladder neoplasm (HP:0009725)2.07890738
41Short humerus (HP:0005792)2.06403252
422-3 toe syndactyly (HP:0004691)2.05731848
43Thyroid carcinoma (HP:0002890)2.05275024
44Hypoplastic nipples (HP:0002557)2.03933319
45Hyperkalemia (HP:0002153)2.01221290
46Abnormality of incisor morphology (HP:0011063)2.00365633
47Ulnar bowing (HP:0003031)1.99475715
48Narrow palate (HP:0000189)1.98899098
49Ectopic kidney (HP:0000086)1.96734300
50Abnormality of the fingertips (HP:0001211)1.95583474
51Abnormality of the 4th metacarpal (HP:0010012)1.94519717
52Gastrointestinal carcinoma (HP:0002672)1.94367158
53Malignant gastrointestinal tract tumors (HP:0006749)1.94367158
54Cerebral aneurysm (HP:0004944)1.93664373
55Aplasia/hypoplasia of the humerus (HP:0006507)1.93161540
56Aortic dissection (HP:0002647)1.92522419
57Hypochromic microcytic anemia (HP:0004840)1.92367050
58Mitral valve prolapse (HP:0001634)1.91937305
59Abnormality of the calcaneus (HP:0008364)1.91658455
60Metaphyseal cupping (HP:0003021)1.89581207
61Leiomyosarcoma (HP:0100243)1.89032974
62Uterine leiomyosarcoma (HP:0002891)1.89032974
63Truncal obesity (HP:0001956)1.88637816
64Increased mean platelet volume (HP:0011877)1.87666165
65Abnormal auditory evoked potentials (HP:0006958)1.87285439
66Increased connective tissue (HP:0009025)1.86445128
67Spastic diplegia (HP:0001264)1.86267329
68Wide nose (HP:0000445)1.85757606
69Absent frontal sinuses (HP:0002688)1.85627983
70Pigmentary retinal degeneration (HP:0001146)1.84399983
71Short chin (HP:0000331)1.83231128
72Rhabdomyosarcoma (HP:0002859)1.83005045
73Vascular tortuosity (HP:0004948)1.81673204
74Cervical subluxation (HP:0003308)1.81183794
75High pitched voice (HP:0001620)1.79425063
76Mesomelia (HP:0003027)1.78833799
77Increased number of teeth (HP:0011069)1.78597703
78Facial hemangioma (HP:0000329)1.78214613
79Broad thumb (HP:0011304)1.77217967
80Acanthocytosis (HP:0001927)1.76614033
81Radial bowing (HP:0002986)1.76461984
82Esophageal varix (HP:0002040)1.76028113
8311 pairs of ribs (HP:0000878)1.75739948
84Deep philtrum (HP:0002002)1.75097165
85Overlapping toe (HP:0001845)1.74090582
86Long eyelashes (HP:0000527)1.73873211
87Ependymoma (HP:0002888)1.73847679
88Abnormal biliary tract morphology (HP:0012440)1.73297437
89Sandal gap (HP:0001852)1.72701838
90Synophrys (HP:0000664)1.72589523
91Viral hepatitis (HP:0006562)1.72380379
92Tapered finger (HP:0001182)1.72339093
93Synostosis of carpal bones (HP:0005048)1.72325125
94Median cleft lip (HP:0000161)1.72312559
95Aqueductal stenosis (HP:0002410)1.71952867
96Fused cervical vertebrae (HP:0002949)1.71744455
97Micronodular cirrhosis (HP:0001413)1.71675572
98Abnormality of the nasal septum (HP:0000419)1.71009203
99Choroideremia (HP:0001139)1.69277505
100Limited elbow extension (HP:0001377)1.69175135
101Fair hair (HP:0002286)1.68408294
102Broad palm (HP:0001169)1.67692171
103Myocardial infarction (HP:0001658)1.67562297
104Submucous cleft hard palate (HP:0000176)1.67322202
105Milia (HP:0001056)1.65770292
106Skull defect (HP:0001362)1.65203170
107Clubbing of toes (HP:0100760)1.64765784
108Hypoplastic labia majora (HP:0000059)1.64301582
109Aneurysm (HP:0002617)1.64283829
110Tibial bowing (HP:0002982)1.64214358
111Portal hypertension (HP:0001409)1.63242204
112Abnormality of the hepatic vasculature (HP:0006707)1.63226877
113Neonatal short-limb short stature (HP:0008921)1.62960797
114Neonatal hypoglycemia (HP:0001998)1.62812588
115Soft skin (HP:0000977)1.62627704
116Astrocytoma (HP:0009592)1.62452163
117Abnormality of the astrocytes (HP:0100707)1.62452163
118Abnormality of chloride homeostasis (HP:0011422)1.62425008
119Large earlobe (HP:0009748)1.61715083
120Hepatocellular carcinoma (HP:0001402)1.61569288
121Wrist flexion contracture (HP:0001239)1.61364760
122Anal stenosis (HP:0002025)1.60747015
123Abnormal platelet volume (HP:0011876)1.60743093
124Abnormality of chromosome segregation (HP:0002916)1.60283109
125Neoplasm of the tracheobronchial system (HP:0100552)1.59306962
126Renal cell carcinoma (HP:0005584)1.59202088
127Acute myeloid leukemia (HP:0004808)1.58888089
128Increased density of long bones (HP:0006392)1.58698319
129Cortical dysplasia (HP:0002539)1.58011753
130Papillary thyroid carcinoma (HP:0002895)1.56874796
131Chronic bronchitis (HP:0004469)1.56682303
132Absent radius (HP:0003974)1.55568410
133Hypoplastic iliac wings (HP:0002866)1.55354529
134Thickened calvaria (HP:0002684)1.54929832
135Neoplasm of the rectum (HP:0100743)1.54871269
136Spinal cord lesions (HP:0100561)1.54798650
137Syringomyelia (HP:0003396)1.54798650
138Abnormality of the distal phalanx of the thumb (HP:0009617)1.54370328
139Prostate neoplasm (HP:0100787)1.54149785
140Increased nuchal translucency (HP:0010880)1.54126414
141Myelodysplasia (HP:0002863)1.53780615
142Abnormal foot bone ossification (HP:0010675)1.53709603
143Neoplasm of the oral cavity (HP:0100649)1.53554685
144Pseudobulbar signs (HP:0002200)1.53541526
145Central scotoma (HP:0000603)1.53475710
146Wide intermamillary distance (HP:0006610)1.53318836
147T lymphocytopenia (HP:0005403)1.52272277
148Periodontitis (HP:0000704)1.52126741
149Heterotopia (HP:0002282)1.51945964
150Thoracolumbar scoliosis (HP:0002944)1.51916353
151Exostoses (HP:0100777)1.51453521
152Vascular calcification (HP:0004934)1.51293528
153Uterine neoplasm (HP:0010784)1.51269543
154Abnormal vertebral ossification (HP:0100569)1.50938228
155Dislocated radial head (HP:0003083)1.50682436
156Neoplasm of the small intestine (HP:0100833)1.49005976
157Abnormality of the proximal phalanges of the hand (HP:0009834)1.48881399
158Conjunctival telangiectasia (HP:0000524)1.48264924
159Abnormality of DNA repair (HP:0003254)1.48103443
160Medulloblastoma (HP:0002885)1.47989674
161Carpal synostosis (HP:0009702)1.47606154
162Poikilocytosis (HP:0004447)1.47452211
163Impulsivity (HP:0100710)1.46991477
164Prominent nose (HP:0000448)1.46949296
165Vertebral clefting (HP:0008428)1.46779576
166Short middle phalanx of the 5th finger (HP:0004220)1.46759282
167Orchitis (HP:0100796)1.46445194
168Nephroblastoma (Wilms tumor) (HP:0002667)1.46020440
169Neoplasm of striated muscle (HP:0009728)1.45574445
170Broad phalanges of the hand (HP:0009768)1.45460636
171Ovarian neoplasm (HP:0100615)1.44302771
172Cutaneous finger syndactyly (HP:0010554)1.43985889

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS14.02509963
2BLK3.84830698
3TAOK33.20403729
4CDK123.16953790
5CDC72.73918639
6FRK2.27545559
7AKT32.18173066
8STK32.08716597
9CAMKK21.99545598
10TTN1.98835802
11PKN21.96592821
12NEK21.94560279
13EPHA21.91870165
14TTK1.91188468
15STK101.84625891
16MAP3K21.81625008
17STK38L1.72412693
18WEE11.70216641
19BRSK21.64970186
20NUAK11.60572200
21MAP3K101.59757591
22PDGFRA1.59440336
23RPS6KA41.49439983
24RPS6KB21.45955598
25CDK61.45652721
26EEF2K1.45566864
27YES11.43445784
28AURKB1.42516753
29WNK11.41519916
30MELK1.38907773
31ZAK1.38877884
32PTK61.38826683
33TRPM71.36993035
34SRPK11.35537306
35BRD41.33738808
36SCYL21.32695010
37STK41.28428000
38STK391.27519175
39MAP3K81.25147695
40CDK41.24917378
41ERBB41.24859688
42CAMK1D1.22806529
43MET1.22631572
44PDK21.20176914
45DDR21.19846598
46DYRK31.16935979
47MST41.16792642
48ERBB31.16039369
49NEK91.14786213
50TLK11.14641938
51TGFBR11.14260541
52MAP3K61.14035885
53SIK11.12893461
54MAP2K31.12502438
55TRIB31.11618472
56FGFR21.11147571
57PNCK1.10562612
58IRAK11.10463621
59PASK1.09788314
60PLK41.09027011
61ATR1.07311235
62TEC1.07085175
63PIK3CG1.06258801
64CHEK21.05769227
65PLK11.05743870
66FLT31.05440185
67MTOR1.04075048
68CDK91.03741472
69CDK71.01216018
70ATM1.01083639
71KSR11.00238783
72RIPK10.98356702
73CHEK10.97071808
74SGK20.94721618
75ACVR1B0.93037431
76LRRK20.90150998
77PAK20.89466588
78FGFR30.88960294
79PLK30.88277654
80MAP3K90.86231249
81PDGFRB0.86150950
82PIM10.85475015
83BMX0.82185152
84MKNK10.78714458
85CAMK40.77373203
86MARK30.77073002
87TGFBR20.76100588
88IRAK20.76095891
89FGFR10.74929849
90MST1R0.72941449
91BMPR20.72626237
92SGK30.68741808
93MAP3K30.67901913
94JAK30.67700718
95PBK0.66639009
96EPHA30.66556100
97CHUK0.65514060
98RPS6KA50.65434886
99MAP3K70.65430803
100LATS20.64419192
101BUB10.63956215
102FGFR40.63928723
103PAK40.63863126
104IRAK40.61623564
105OXSR10.61119775
106NEK60.59695579
107CDK20.59565886
108TNK20.58388076
109BMPR1B0.57036398
110PTK2B0.56972443
111MKNK20.56112622
112FER0.54694155
113PTK20.54397029
114GSK3A0.53815913
115MAPK110.53494828
116STK240.52236930
117MAP3K140.51364991
118ERBB20.50136194
119* CDK10.50031848
120CSK0.49661756
121EIF2AK10.49270216
122PIK3CA0.47401221
123DMPK0.46499623
124AKT20.45994156
125JAK10.45863469
126CSNK1D0.45829515
127STK380.44045869
128NEK10.43365945
129PRKAA20.43087700
130WNK40.41761181
131STK110.41208500
132JAK20.41146073
133PRKDC0.40588090
134NLK0.40222156
135AKT10.39731999
136CAMK1G0.38731408
137RET0.38639903
138EIF2AK30.38583385
139TYK20.38410368
140RPS6KB10.38318843
141EPHB20.37738017
142HIPK20.37377762
143SGK10.36834891

Predicted pathways (KEGG)

RankGene SetZ-score
1Systemic lupus erythematosus_Homo sapiens_hsa053222.57125544
2Regulation of autophagy_Homo sapiens_hsa041402.39530297
3Cell cycle_Homo sapiens_hsa041102.26904590
4One carbon pool by folate_Homo sapiens_hsa006702.13175570
5RNA transport_Homo sapiens_hsa030131.96054036
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.93955407
7Adherens junction_Homo sapiens_hsa045201.89591783
8Small cell lung cancer_Homo sapiens_hsa052221.81323436
9p53 signaling pathway_Homo sapiens_hsa041151.80267674
10Lysine degradation_Homo sapiens_hsa003101.77365970
11MicroRNAs in cancer_Homo sapiens_hsa052061.76844046
12Mismatch repair_Homo sapiens_hsa034301.73072000
13RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.73056401
14Selenocompound metabolism_Homo sapiens_hsa004501.73039509
15ECM-receptor interaction_Homo sapiens_hsa045121.66968431
16DNA replication_Homo sapiens_hsa030301.63228317
17Fanconi anemia pathway_Homo sapiens_hsa034601.54945967
18Non-small cell lung cancer_Homo sapiens_hsa052231.52799178
19Viral carcinogenesis_Homo sapiens_hsa052031.51250550
20Propanoate metabolism_Homo sapiens_hsa006401.51200397
21TGF-beta signaling pathway_Homo sapiens_hsa043501.48071446
22Circadian rhythm_Homo sapiens_hsa047101.46281378
23Spliceosome_Homo sapiens_hsa030401.43360622
24mRNA surveillance pathway_Homo sapiens_hsa030151.37820010
25Non-homologous end-joining_Homo sapiens_hsa034501.34131451
26Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.30256504
27Focal adhesion_Homo sapiens_hsa045101.23429725
28Homologous recombination_Homo sapiens_hsa034401.23120771
29Phosphatidylinositol signaling system_Homo sapiens_hsa040701.22912567
30Inositol phosphate metabolism_Homo sapiens_hsa005621.20806487
31RNA degradation_Homo sapiens_hsa030181.20343839
32Renal cell carcinoma_Homo sapiens_hsa052111.19576831
33Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.18212906
34Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.17539396
35Proteoglycans in cancer_Homo sapiens_hsa052051.17253170
36Hippo signaling pathway_Homo sapiens_hsa043901.16634040
37Nucleotide excision repair_Homo sapiens_hsa034201.14822940
38Transcriptional misregulation in cancer_Homo sapiens_hsa052021.11905875
39Herpes simplex infection_Homo sapiens_hsa051681.11777934
40Prostate cancer_Homo sapiens_hsa052151.11513059
41Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.10346202
42Nitrogen metabolism_Homo sapiens_hsa009101.09237438
43Basal cell carcinoma_Homo sapiens_hsa052171.04779638
44Choline metabolism in cancer_Homo sapiens_hsa052311.02262807
45HTLV-I infection_Homo sapiens_hsa051661.00612255
46Bladder cancer_Homo sapiens_hsa052191.00338181
47Platelet activation_Homo sapiens_hsa046110.99924115
48Antigen processing and presentation_Homo sapiens_hsa046120.98476539
49Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.96349310
50Basal transcription factors_Homo sapiens_hsa030220.96285703
51NF-kappa B signaling pathway_Homo sapiens_hsa040640.95567284
52Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.95328236
53Chronic myeloid leukemia_Homo sapiens_hsa052200.93521702
54Caffeine metabolism_Homo sapiens_hsa002320.92404842
55Longevity regulating pathway - mammal_Homo sapiens_hsa042110.92183714
56Base excision repair_Homo sapiens_hsa034100.89940515
57Glucagon signaling pathway_Homo sapiens_hsa049220.87370940
58Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.85263467
59Thyroid hormone signaling pathway_Homo sapiens_hsa049190.84928406
60Tight junction_Homo sapiens_hsa045300.83528656
61Viral myocarditis_Homo sapiens_hsa054160.82322615
62Fatty acid biosynthesis_Homo sapiens_hsa000610.82039293
63Ether lipid metabolism_Homo sapiens_hsa005650.82009114
64Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.81379595
65Linoleic acid metabolism_Homo sapiens_hsa005910.81295995
66Pancreatic cancer_Homo sapiens_hsa052120.80326177
67Legionellosis_Homo sapiens_hsa051340.79175462
68Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.79166216
69ErbB signaling pathway_Homo sapiens_hsa040120.76268191
70Thyroid cancer_Homo sapiens_hsa052160.74575524
71Complement and coagulation cascades_Homo sapiens_hsa046100.74545187
72Leukocyte transendothelial migration_Homo sapiens_hsa046700.74400989
73FoxO signaling pathway_Homo sapiens_hsa040680.73840171
74Prolactin signaling pathway_Homo sapiens_hsa049170.73506633
75Protein digestion and absorption_Homo sapiens_hsa049740.72374962
76Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.71962210
77Acute myeloid leukemia_Homo sapiens_hsa052210.71140291
78PPAR signaling pathway_Homo sapiens_hsa033200.69927354
79alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.69780971
80Fatty acid degradation_Homo sapiens_hsa000710.69304180
81Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.69067787
82Dorso-ventral axis formation_Homo sapiens_hsa043200.68822008
83Renin-angiotensin system_Homo sapiens_hsa046140.68739337
84Pathways in cancer_Homo sapiens_hsa052000.68139639
85Insulin resistance_Homo sapiens_hsa049310.67475837
86Hepatitis B_Homo sapiens_hsa051610.66616177
87Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.66404844
88NOD-like receptor signaling pathway_Homo sapiens_hsa046210.65250644
89* PI3K-Akt signaling pathway_Homo sapiens_hsa041510.64948625
90AMPK signaling pathway_Homo sapiens_hsa041520.64821253
91Osteoclast differentiation_Homo sapiens_hsa043800.64519742
92Maturity onset diabetes of the young_Homo sapiens_hsa049500.64136628
93TNF signaling pathway_Homo sapiens_hsa046680.63126991
94B cell receptor signaling pathway_Homo sapiens_hsa046620.62418744
95Notch signaling pathway_Homo sapiens_hsa043300.61946127
96Amoebiasis_Homo sapiens_hsa051460.61884737
97Alcoholism_Homo sapiens_hsa050340.61385892
98Glycerophospholipid metabolism_Homo sapiens_hsa005640.60939168
99Fat digestion and absorption_Homo sapiens_hsa049750.60534705
100Toxoplasmosis_Homo sapiens_hsa051450.59346580
101Hepatitis C_Homo sapiens_hsa051600.59287199
102mTOR signaling pathway_Homo sapiens_hsa041500.58880761
103Apoptosis_Homo sapiens_hsa042100.58704226
104Steroid hormone biosynthesis_Homo sapiens_hsa001400.58381401
105Measles_Homo sapiens_hsa051620.57970195
106Central carbon metabolism in cancer_Homo sapiens_hsa052300.56330655
107Melanoma_Homo sapiens_hsa052180.54706284
108Glioma_Homo sapiens_hsa052140.54499845
109Thyroid hormone synthesis_Homo sapiens_hsa049180.54011403
110AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.53604693
111Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.53013164
112Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.52386158
113Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.51465156
114Vitamin B6 metabolism_Homo sapiens_hsa007500.51278074
115Tryptophan metabolism_Homo sapiens_hsa003800.50818635
116Drug metabolism - other enzymes_Homo sapiens_hsa009830.49809051
117Vitamin digestion and absorption_Homo sapiens_hsa049770.49409935
118Endometrial cancer_Homo sapiens_hsa052130.48201307
119Fatty acid metabolism_Homo sapiens_hsa012120.48039458
120Epstein-Barr virus infection_Homo sapiens_hsa051690.47826865
121Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.44889393
122Retinol metabolism_Homo sapiens_hsa008300.44801860
123Regulation of actin cytoskeleton_Homo sapiens_hsa048100.44534485
124Malaria_Homo sapiens_hsa051440.44531309
125Colorectal cancer_Homo sapiens_hsa052100.44320180
126Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.44005741
127Starch and sucrose metabolism_Homo sapiens_hsa005000.43926555
128Jak-STAT signaling pathway_Homo sapiens_hsa046300.42932758
129Biosynthesis of amino acids_Homo sapiens_hsa012300.42311968
130Influenza A_Homo sapiens_hsa051640.41684792
131Arginine biosynthesis_Homo sapiens_hsa002200.41605117
132Hedgehog signaling pathway_Homo sapiens_hsa043400.40423670

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