PKN3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of translational fidelity (GO:0006450)4.73512136
2viral transcription (GO:0019083)4.60475934
3translational termination (GO:0006415)4.49402091
4maturation of SSU-rRNA (GO:0030490)4.43050945
5ribosomal small subunit biogenesis (GO:0042274)4.24046374
6proline biosynthetic process (GO:0006561)4.05499788
7ribosomal small subunit assembly (GO:0000028)4.04524614
8protein localization to kinetochore (GO:0034501)3.96400955
9translational elongation (GO:0006414)3.88369801
10DNA unwinding involved in DNA replication (GO:0006268)3.84598329
11regulation of mammary gland epithelial cell proliferation (GO:0033599)3.79989296
12mitotic nuclear envelope reassembly (GO:0007084)3.77174463
13nuclear envelope reassembly (GO:0031468)3.77174463
14negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.76878692
15DNA replication initiation (GO:0006270)3.71762872
16peptidyl-arginine omega-N-methylation (GO:0035247)3.69889292
17nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.69795149
18translational initiation (GO:0006413)3.69606816
19morphogenesis of an endothelium (GO:0003159)3.61343428
20endothelial tube morphogenesis (GO:0061154)3.61343428
21chromosome condensation (GO:0030261)3.60512392
22DNA topological change (GO:0006265)3.58590036
23ribosomal large subunit biogenesis (GO:0042273)3.57441283
24DNA strand elongation involved in DNA replication (GO:0006271)3.57132231
25folic acid metabolic process (GO:0046655)3.55495789
26regulation of spindle organization (GO:0090224)3.54811772
27chromatin assembly (GO:0031497)3.54605102
28SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.50558044
29formation of translation preinitiation complex (GO:0001731)3.45576262
30mitotic nuclear envelope disassembly (GO:0007077)3.45405471
31viral life cycle (GO:0019058)3.45314418
32cellular protein complex disassembly (GO:0043624)3.43187556
33viral mRNA export from host cell nucleus (GO:0046784)3.42921443
34protein targeting to ER (GO:0045047)3.40846168
35cotranslational protein targeting to membrane (GO:0006613)3.39804903
36DNA conformation change (GO:0071103)3.37891016
37DNA strand elongation (GO:0022616)3.32906452
38protein localization to chromosome, centromeric region (GO:0071459)3.28907253
39nucleobase-containing small molecule interconversion (GO:0015949)3.28839837
40mitotic metaphase plate congression (GO:0007080)3.28433740
41peptidyl-arginine N-methylation (GO:0035246)3.27665722
42peptidyl-arginine methylation (GO:0018216)3.27665722
43spliceosomal tri-snRNP complex assembly (GO:0000244)3.25719727
44establishment of protein localization to endoplasmic reticulum (GO:0072599)3.25011732
45telomere maintenance via semi-conservative replication (GO:0032201)3.22030033
46ribonucleoprotein complex biogenesis (GO:0022613)3.21233147
47DNA packaging (GO:0006323)3.19697226
48membrane disassembly (GO:0030397)3.19484625
49nuclear envelope disassembly (GO:0051081)3.19484625
50regulation of mitotic spindle organization (GO:0060236)3.18897440
51mitotic sister chromatid cohesion (GO:0007064)3.17874947
52negative regulation of mRNA processing (GO:0050686)3.15066997
53rRNA transcription (GO:0009303)3.14145606
54protein localization to endoplasmic reticulum (GO:0070972)3.13462321
55endothelium development (GO:0003158)3.13128035
56protein complex disassembly (GO:0043241)3.11299997
57nucleobase biosynthetic process (GO:0046112)3.09943878
58positive regulation of DNA-dependent DNA replication (GO:2000105)3.09532017
59histone arginine methylation (GO:0034969)3.07646227
60protein-DNA complex disassembly (GO:0032986)3.06710040
61nucleosome disassembly (GO:0006337)3.06710040
62protein complex localization (GO:0031503)3.06698111
63pore complex assembly (GO:0046931)3.05880624
64regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.04250760
65DNA replication checkpoint (GO:0000076)3.03883514
66metaphase plate congression (GO:0051310)3.03349523
67IMP biosynthetic process (GO:0006188)3.02530669
68mitotic sister chromatid segregation (GO:0000070)3.01822270
69heterochromatin organization (GO:0070828)3.00821750
70L-serine metabolic process (GO:0006563)3.00411196
71negative regulation of mRNA metabolic process (GO:1903312)2.99631528
72DNA replication-dependent nucleosome assembly (GO:0006335)2.98557267
73DNA replication-dependent nucleosome organization (GO:0034723)2.98557267
74deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.98317318
75DNA strand renaturation (GO:0000733)2.97667934
76DNA synthesis involved in DNA repair (GO:0000731)2.97550197
77regulation of translational termination (GO:0006449)2.97092928
78chromatin assembly or disassembly (GO:0006333)2.93880705
79negative regulation of RNA splicing (GO:0033119)2.93372575
80telomere maintenance via recombination (GO:0000722)2.92266489
81nuclear pore organization (GO:0006999)2.90714035
82regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.88877640
83apoptotic process involved in morphogenesis (GO:0060561)2.88738708
84macromolecular complex disassembly (GO:0032984)2.84818579
85regulation of gene silencing by RNA (GO:0060966)2.84442856
86regulation of posttranscriptional gene silencing (GO:0060147)2.84442856
87regulation of gene silencing by miRNA (GO:0060964)2.84442856
88positive regulation of chromosome segregation (GO:0051984)2.84350234
89mitochondrial DNA metabolic process (GO:0032042)2.83520324
90mitotic G1 DNA damage checkpoint (GO:0031571)2.82910131
91IMP metabolic process (GO:0046040)2.82615117
92positive regulation of cell cycle checkpoint (GO:1901978)2.79315870
93cellular protein complex localization (GO:0034629)2.79308940
94establishment of integrated proviral latency (GO:0075713)2.79202169
95nuclear-transcribed mRNA catabolic process (GO:0000956)2.79083961
96mitotic recombination (GO:0006312)2.77078064
97positive regulation of vasculogenesis (GO:2001214)2.76222138
98ribosome biogenesis (GO:0042254)2.76054886
99regulation of RNA export from nucleus (GO:0046831)2.75489323
100chromosome segregation (GO:0007059)2.75150917
101ribosome assembly (GO:0042255)2.75127493
102purine nucleobase biosynthetic process (GO:0009113)2.74925522
103lymph vessel development (GO:0001945)2.74190325
104histone phosphorylation (GO:0016572)2.73047757
105proline metabolic process (GO:0006560)2.72956687
106oxidative phosphorylation (GO:0006119)2.72496273
107positive regulation of osteoblast proliferation (GO:0033690)2.69990674
108pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.68749330
109kinetochore organization (GO:0051383)2.68250171
110mitotic chromosome condensation (GO:0007076)2.67885902
111nuclear pore complex assembly (GO:0051292)2.66961259
112mRNA catabolic process (GO:0006402)2.66867880
113nuclear envelope organization (GO:0006998)2.66142772
114sister chromatid segregation (GO:0000819)2.63843301
115rRNA processing (GO:0006364)2.61588847
116telomere maintenance via telomere lengthening (GO:0010833)2.61528318
117snRNA metabolic process (GO:0016073)2.61203059
118pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.60845249
119CENP-A containing nucleosome assembly (GO:0034080)2.60094074
120pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.59761670
121translesion synthesis (GO:0019985)2.59493350
122Golgi transport vesicle coating (GO:0048200)2.58965510
123COPI coating of Golgi vesicle (GO:0048205)2.58965510
124mitotic G1/S transition checkpoint (GO:0044819)2.58427058
125RNA catabolic process (GO:0006401)2.58258410
126endothelial cell morphogenesis (GO:0001886)2.57923381
127basement membrane organization (GO:0071711)2.56544170
128regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.55963597
129chromatin remodeling at centromere (GO:0031055)2.53412134
130establishment of chromosome localization (GO:0051303)2.52437088
131folic acid-containing compound biosynthetic process (GO:0009396)2.52001839
132rRNA metabolic process (GO:0016072)2.51932703
133hemidesmosome assembly (GO:0031581)2.47705505
134blood vessel maturation (GO:0001955)2.47468969
135cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.46722768
136negative regulation of chromosome segregation (GO:0051985)2.46491662
137kinetochore assembly (GO:0051382)2.46399582
138regulation of SMAD protein import into nucleus (GO:0060390)2.45049422
139nucleotide-excision repair, DNA gap filling (GO:0006297)2.45001772
140regulation of integrin activation (GO:0033623)2.44463909
141regulation of endothelial cell differentiation (GO:0045601)2.44454603
142positive regulation of SMAD protein import into nucleus (GO:0060391)2.43445541
143regulation of chromosome segregation (GO:0051983)2.42605620
144DNA replication-independent nucleosome organization (GO:0034724)2.42546675
145DNA replication-independent nucleosome assembly (GO:0006336)2.42546675
146DNA duplex unwinding (GO:0032508)2.41495993
147mitotic G2/M transition checkpoint (GO:0044818)2.41443140
1483-UTR-mediated mRNA stabilization (GO:0070935)2.41106341
149DNA geometric change (GO:0032392)2.40715437
150mitotic G2 DNA damage checkpoint (GO:0007095)2.39861147
151maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.39166118
152DNA deamination (GO:0045006)2.38065808
153vascular endothelial growth factor signaling pathway (GO:0038084)2.37617228
154regulation of telomere maintenance via telomerase (GO:0032210)2.37539022

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.70699285
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.21245967
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.58666118
4TP63_17297297_ChIP-ChIP_HaCaT_Human3.23142687
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.05556287
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.85636101
7E2F4_17652178_ChIP-ChIP_JURKAT_Human2.81609416
8MYC_19079543_ChIP-ChIP_MESCs_Mouse2.76646477
9MYC_19030024_ChIP-ChIP_MESCs_Mouse2.24702877
10MYC_18358816_ChIP-ChIP_MESCs_Mouse2.18800256
11EGR1_19374776_ChIP-ChIP_THP-1_Human2.16220693
12XRN2_22483619_ChIP-Seq_HELA_Human2.01366795
13THAP11_20581084_ChIP-Seq_MESCs_Mouse2.00004332
14NELFA_20434984_ChIP-Seq_ESCs_Mouse1.93189950
15MYC_22102868_ChIP-Seq_BL_Human1.92316495
16NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.90958028
17AR_21909140_ChIP-Seq_LNCAP_Human1.85599171
18ETS1_20019798_ChIP-Seq_JURKAT_Human1.80705178
19LXR_22292898_ChIP-Seq_THP-1_Human1.78160062
20CREB1_15753290_ChIP-ChIP_HEK293T_Human1.76920854
21KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.76472514
22KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.76472514
23KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.76472514
24STAT3_1855785_ChIP-Seq_MESCs_Mouse1.75760883
25NANOG_18555785_ChIP-Seq_MESCs_Mouse1.74665265
26EST1_17652178_ChIP-ChIP_JURKAT_Human1.74452440
27TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.72489073
28POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.70872284
29ELK3_25401928_ChIP-Seq_HUVEC_Human1.70463549
30SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.62307213
31HIF1A_21447827_ChIP-Seq_MCF-7_Human1.57932245
32E2F1_18555785_ChIP-Seq_MESCs_Mouse1.56924480
33NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.54513964
34CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.54301218
35ZNF263_19887448_ChIP-Seq_K562_Human1.54065983
36MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.54024239
37KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.53548684
38TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.50655988
39KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.47184788
40ESR1_15608294_ChIP-ChIP_MCF-7_Human1.47005561
41* VDR_21846776_ChIP-Seq_THP-1_Human1.46911431
42E2F1_21310950_ChIP-Seq_MCF-7_Human1.46723750
43RACK7_27058665_Chip-Seq_MCF-7_Human1.45559048
44MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.45547108
45TCF3_18692474_ChIP-Seq_MEFs_Mouse1.43731015
46CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.42624528
47POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.41457255
48CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.41170466
49* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.39404338
50JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.38389728
51P68_20966046_ChIP-Seq_HELA_Human1.38214996
52TTF2_22483619_ChIP-Seq_HELA_Human1.38063307
53SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.37115797
54TET1_21451524_ChIP-Seq_MESCs_Mouse1.36847688
55PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.36620859
56SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.36159380
57TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.35939884
58HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.29719386
59MYCN_18555785_ChIP-Seq_MESCs_Mouse1.29590978
60VDR_23849224_ChIP-Seq_CD4+_Human1.29389727
61GABP_17652178_ChIP-ChIP_JURKAT_Human1.26897650
62* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.25369360
63FOXP3_21729870_ChIP-Seq_TREG_Human1.24217356
64DCP1A_22483619_ChIP-Seq_HELA_Human1.23645515
65KDM2B_26808549_Chip-Seq_SUP-B15_Human1.22818951
66TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.21788047
67DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.18537922
68CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.17627950
69KDM2B_26808549_Chip-Seq_DND41_Human1.17605833
70CIITA_25753668_ChIP-Seq_RAJI_Human1.17294239
71SOX2_18555785_ChIP-Seq_MESCs_Mouse1.16711601
72EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.16375404
73ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.15229684
74KDM5A_27292631_Chip-Seq_BREAST_Human1.15174091
75* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.14860398
76* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.13147947
77CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.12867513
78GABP_19822575_ChIP-Seq_HepG2_Human1.12603998
79KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.11708258
80SRY_22984422_ChIP-ChIP_TESTIS_Rat1.10961829
81NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.10931594
82STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.09378994
83SCL_19346495_ChIP-Seq_HPC-7_Human1.07594555
84CTCF_27219007_Chip-Seq_ERYTHROID_Human1.07468006
85* TCF7_22412390_ChIP-Seq_EML_Mouse1.07441023
86E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.07356948
87ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.06744513
88ATF3_27146783_Chip-Seq_COLON_Human1.06483977
89STAT6_21828071_ChIP-Seq_BEAS2B_Human1.06005564
90CLOCK_20551151_ChIP-Seq_293T_Human1.05992103
91TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.05468159
92SOX2_18692474_ChIP-Seq_MEFs_Mouse1.05148062
93SA1_27219007_Chip-Seq_ERYTHROID_Human1.04804679
94BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.04622700
95SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.04575711
96YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.03447186
97KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.02356335
98ERG_20887958_ChIP-Seq_HPC-7_Mouse1.02309855
99ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.02083894
100ELF1_20517297_ChIP-Seq_JURKAT_Human1.01789478
101UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.01496036
102MYB_21317192_ChIP-Seq_ERMYB_Mouse1.01463062
103YY1_21170310_ChIP-Seq_MESCs_Mouse1.01055669
104OCT4_18692474_ChIP-Seq_MEFs_Mouse1.00302447
105MAF_26560356_Chip-Seq_TH1_Human1.00087856
106* MAF_26560356_Chip-Seq_TH2_Human0.99910433
107KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.99335957
108NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.99236462
109SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.98690298
110KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.98234795
111PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.98218231
112RARG_19884340_ChIP-ChIP_MEFs_Mouse0.97911297
113ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.97808293
114* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.97723150
115SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.97472764
116* NCOR1_26117541_ChIP-Seq_K562_Human0.97225181
117NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.97126397
118PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.97111387
119TFEB_21752829_ChIP-Seq_HELA_Human0.96853342
120* FOXP1_21924763_ChIP-Seq_HESCs_Human0.96524992
121CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.95944708
122KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.95786388
123SPI1_23547873_ChIP-Seq_NB4_Human0.95331689
124NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.95168359
125THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.95096112
126TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.95047517
127CREB1_26743006_Chip-Seq_LNCaP_Human0.94903241
128ELK1_19687146_ChIP-ChIP_HELA_Human0.93977640
129PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.93937588
130POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.93728601
131HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.93415786
132SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.92818517
133TCF3_18692474_ChIP-Seq_MESCs_Mouse0.92245880
134FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.90985540
135ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.89739427
136TP63_19390658_ChIP-ChIP_HaCaT_Human0.89266066

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010368_abnormal_lymphatic_system3.88141054
2MP0003693_abnormal_embryo_hatching2.83955487
3MP0001879_abnormal_lymphatic_vessel2.72215039
4MP0003705_abnormal_hypodermis_morpholog2.70039678
5MP0001661_extended_life_span2.58286482
6MP0003111_abnormal_nucleus_morphology2.55574583
7MP0005167_abnormal_blood-brain_barrier2.52335561
8MP0002877_abnormal_melanocyte_morpholog2.49060967
9MP0004957_abnormal_blastocyst_morpholog2.43584529
10MP0003077_abnormal_cell_cycle2.31001180
11MP0010352_gastrointestinal_tract_polyps2.29414845
12MP0010094_abnormal_chromosome_stability2.22895859
13MP0000678_abnormal_parathyroid_gland2.19232719
14MP0003828_pulmonary_edema2.14970045
15MP0008057_abnormal_DNA_replication2.14235852
16MP0004084_abnormal_cardiac_muscle2.02321209
17MP0005451_abnormal_body_composition1.99064010
18MP0003566_abnormal_cell_adhesion1.93135076
19MP0002396_abnormal_hematopoietic_system1.90332917
20MP0002249_abnormal_larynx_morphology1.85269202
21MP0000003_abnormal_adipose_tissue1.81816657
22MP0004272_abnormal_basement_membrane1.81809181
23MP0008007_abnormal_cellular_replicative1.78224126
24MP0001730_embryonic_growth_arrest1.75107212
25MP0009278_abnormal_bone_marrow1.72498069
26MP0004233_abnormal_muscle_weight1.72449355
27MP0003567_abnormal_fetal_cardiomyocyte1.66782474
28MP0003984_embryonic_growth_retardation1.55738659
29MP0004808_abnormal_hematopoietic_stem1.55448380
30MP0001672_abnormal_embryogenesis/_devel1.54879796
31MP0005380_embryogenesis_phenotype1.54879796
32MP0002088_abnormal_embryonic_growth/wei1.54238058
33MP0002086_abnormal_extraembryonic_tissu1.53772590
34MP0005666_abnormal_adipose_tissue1.50470446
35MP0008932_abnormal_embryonic_tissue1.49246801
36MP0000350_abnormal_cell_proliferation1.48213940
37MP0002132_abnormal_respiratory_system1.47258720
38MP0000767_abnormal_smooth_muscle1.45715887
39MP0005397_hematopoietic_system_phenotyp1.39334426
40MP0001545_abnormal_hematopoietic_system1.39334426
41MP0009672_abnormal_birth_weight1.38933787
42MP0005375_adipose_tissue_phenotype1.38233296
43MP0001697_abnormal_embryo_size1.36656137
44MP0002234_abnormal_pharynx_morphology1.35289948
45MP0001346_abnormal_lacrimal_gland1.34992880
46MP0010630_abnormal_cardiac_muscle1.32714006
47MP0006054_spinal_hemorrhage1.31191898
48MP0003941_abnormal_skin_development1.31011987
49MP0000537_abnormal_urethra_morphology1.29937026
50MP0005023_abnormal_wound_healing1.29756061
51MP0000750_abnormal_muscle_regeneration1.29579358
52MP0010030_abnormal_orbit_morphology1.29506250
53MP0009379_abnormal_foot_pigmentation1.23915518
54MP0002080_prenatal_lethality1.22367491
55MP0002925_abnormal_cardiovascular_devel1.21658474
56MP0002085_abnormal_embryonic_tissue1.18544556
57MP0002084_abnormal_developmental_patter1.16127009
58MP0003123_paternal_imprinting1.14788449
59MP0001348_abnormal_lacrimal_gland1.14592731
60MP0004197_abnormal_fetal_growth/weight/1.12874279
61MP0003279_aneurysm1.12128223
62MP0009333_abnormal_splenocyte_physiolog1.11767580
63MP0003724_increased_susceptibility_to1.10990234
64MP0008058_abnormal_DNA_repair1.09904823
65MP0003385_abnormal_body_wall1.09602223
66MP0003786_premature_aging1.08237237
67MP0002697_abnormal_eye_size1.07624294
68MP0010307_abnormal_tumor_latency1.05667635
69MP0001915_intracranial_hemorrhage1.04795959
70MP0002254_reproductive_system_inflammat1.03494564
71MP0010234_abnormal_vibrissa_follicle1.03067637
72MP0008438_abnormal_cutaneous_collagen1.02983618
73MP0006138_congestive_heart_failure1.02439219
74MP0000013_abnormal_adipose_tissue1.02233424
75MP0005670_abnormal_white_adipose1.02185102
76MP0005330_cardiomyopathy1.02061559
77MP0001849_ear_inflammation0.99678642
78MP0009053_abnormal_anal_canal0.99056651
79MP0009697_abnormal_copulation0.98876900
80MP0000465_gastrointestinal_hemorrhage0.98351886
81MP0000490_abnormal_crypts_of0.98076355
82MP0000049_abnormal_middle_ear0.97567852
83MP0001614_abnormal_blood_vessel0.97373295
84MP0000266_abnormal_heart_morphology0.95401020
85MP0002127_abnormal_cardiovascular_syste0.94665434
86MP0008775_abnormal_heart_ventricle0.94195885
87MP0002128_abnormal_blood_circulation0.94074413
88MP0000343_altered_response_to0.93977045
89MP0001544_abnormal_cardiovascular_syste0.93892921
90MP0005385_cardiovascular_system_phenoty0.93892921
91MP0003119_abnormal_digestive_system0.92976735
92MP0000733_abnormal_muscle_development0.92973552
93MP0003942_abnormal_urinary_system0.92712592
94MP0004185_abnormal_adipocyte_glucose0.92491550
95MP0005076_abnormal_cell_differentiation0.92427394
96MP0002092_abnormal_eye_morphology0.90888189
97MP0003453_abnormal_keratinocyte_physiol0.90538280
98MP0003448_altered_tumor_morphology0.90532566
99MP0000383_abnormal_hair_follicle0.90430141
100MP0000313_abnormal_cell_death0.90011991
101MP0005621_abnormal_cell_physiology0.89590401
102MP0002019_abnormal_tumor_incidence0.88055773
103MP0005058_abnormal_lysosome_morphology0.88022061
104MP0005501_abnormal_skin_physiology0.87928470
105MP0003221_abnormal_cardiomyocyte_apopto0.87822061
106MP0002089_abnormal_postnatal_growth/wei0.87627895
107MP0000759_abnormal_skeletal_muscle0.86718277
108MP0003303_peritoneal_inflammation0.86702431
109MP0003283_abnormal_digestive_organ0.85769452
110MP0004036_abnormal_muscle_relaxation0.85652071
111MP0000747_muscle_weakness0.85607608
112MP0000681_abnormal_thyroid_gland0.84826122
113MP0002111_abnormal_tail_morphology0.84516776
114MP0004858_abnormal_nervous_system0.82977259
115MP0002060_abnormal_skin_morphology0.82939916
116MP0000249_abnormal_blood_vessel0.82447854
117MP0000566_synostosis0.82144930
118MP0005623_abnormal_meninges_morphology0.82136030
119MP0005409_darkened_coat_color0.82040990
120MP0000428_abnormal_craniofacial_morphol0.82004995
121MP0002796_impaired_skin_barrier0.81976799
122MP0002970_abnormal_white_adipose0.80769543
123MP0001784_abnormal_fluid_regulation0.80681517
124MP0004782_abnormal_surfactant_physiolog0.80667175
125MP0004087_abnormal_muscle_fiber0.80575678
126MP0000358_abnormal_cell_content/0.80446925
127MP0003943_abnormal_hepatobiliary_system0.79634358
128MP0006036_abnormal_mitochondrial_physio0.77747616
129MP0005384_cellular_phenotype0.76038205
130MP0003718_maternal_effect0.76013100
131MP0000516_abnormal_urinary_system0.75095403
132MP0005367_renal/urinary_system_phenotyp0.75095403
133MP0002114_abnormal_axial_skeleton0.73320919
134MP0003091_abnormal_cell_migration0.72500828
135MP0008260_abnormal_autophagy0.72232006
136MP0005275_abnormal_skin_tensile0.71830976
137MP0000858_altered_metastatic_potential0.71449414
138MP0006035_abnormal_mitochondrial_morpho0.69412146
139MP0003315_abnormal_perineum_morphology0.69207034
140MP0001881_abnormal_mammary_gland0.67728018
141MP0010678_abnormal_skin_adnexa0.67648409
142MP0002932_abnormal_joint_morphology0.66949831
143MP0000749_muscle_degeneration0.65399223
144MP0001293_anophthalmia0.65250671
145MP0000703_abnormal_thymus_morphology0.63845359

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)3.84599321
2Reticulocytopenia (HP:0001896)3.67688165
3Increased connective tissue (HP:0009025)3.61975983
4Short middle phalanx of the 5th finger (HP:0004220)3.61162688
5Abnormality of cells of the erythroid lineage (HP:0012130)3.54921255
6Abnormal number of erythroid precursors (HP:0012131)3.16592265
7Hyperacusis (HP:0010780)3.13597490
8Hematochezia (HP:0002573)3.09108333
9Selective tooth agenesis (HP:0001592)3.04096415
10Truncus arteriosus (HP:0001660)3.03058142
11Breast hypoplasia (HP:0003187)2.89298766
12Reticulocytosis (HP:0001923)2.88086896
13Ventricular tachycardia (HP:0004756)2.85880602
14Distal lower limb muscle weakness (HP:0009053)2.83059042
15Muscle fiber splitting (HP:0003555)2.75405190
16Polycythemia (HP:0001901)2.70088136
17Trismus (HP:0000211)2.69810117
18Aplasia/Hypoplasia of the sacrum (HP:0008517)2.69278262
19Birth length less than 3rd percentile (HP:0003561)2.60392864
20Spontaneous hematomas (HP:0007420)2.57435175
21Multiple enchondromatosis (HP:0005701)2.55910062
22Broad distal phalanx of finger (HP:0009836)2.52277780
23Microvesicular hepatic steatosis (HP:0001414)2.50505413
24Squamous cell carcinoma (HP:0002860)2.48601551
25Abnormality of cochlea (HP:0000375)2.40933554
26Difficulty climbing stairs (HP:0003551)2.40166425
27Hyperthyroidism (HP:0000836)2.39123116
28Short 5th finger (HP:0009237)2.37829836
29Cerebral aneurysm (HP:0004944)2.36949576
30Pallor (HP:0000980)2.35882743
31Premature rupture of membranes (HP:0001788)2.35644313
32Broad palm (HP:0001169)2.31511177
33Insomnia (HP:0100785)2.30263438
34Protrusio acetabuli (HP:0003179)2.29425560
35Ependymoma (HP:0002888)2.29240529
36Ragged-red muscle fibers (HP:0003200)2.28606077
37Congenital, generalized hypertrichosis (HP:0004540)2.26391870
38Abnormality of the tricuspid valve (HP:0001702)2.25760357
39Adactyly (HP:0009776)2.23885300
40Testicular atrophy (HP:0000029)2.23594555
41Stenosis of the external auditory canal (HP:0000402)2.22927472
42Conjunctival telangiectasia (HP:0000524)2.22278555
43Deep palmar crease (HP:0006191)2.20906801
44Poikiloderma (HP:0001029)2.20877525
45Increased nuchal translucency (HP:0010880)2.20310359
46Colon cancer (HP:0003003)2.19852949
47Macrocytic anemia (HP:0001972)2.19526621
48Rough bone trabeculation (HP:0100670)2.19488878
49Ankle contracture (HP:0006466)2.17428750
50Esophageal varix (HP:0002040)2.17372659
51Carpal bone hypoplasia (HP:0001498)2.16361909
52Areflexia of lower limbs (HP:0002522)2.15716784
53Premature skin wrinkling (HP:0100678)2.15435213
54Abnormal hemoglobin (HP:0011902)2.14667599
55Spinal rigidity (HP:0003306)2.14051948
56Rectal prolapse (HP:0002035)2.11562883
57Glossoptosis (HP:0000162)2.10929632
58Abnormality of the calcaneus (HP:0008364)2.10689150
59Aplastic anemia (HP:0001915)2.10186204
60Skull defect (HP:0001362)2.08943861
61Abnormality of the nasal mucosa (HP:0000433)2.08316958
62Disproportionate tall stature (HP:0001519)2.06902337
63Hypertensive crisis (HP:0100735)2.05821637
64Abnormality of the umbilical cord (HP:0010881)2.02815602
65Aplasia/Hypoplasia of the 5th finger (HP:0006262)2.02717103
66Hypoplasia of the capital femoral epiphysis (HP:0003090)2.01522111
67Abnormal gallbladder physiology (HP:0012438)2.00742679
68Cholecystitis (HP:0001082)2.00742679
69Duplication of thumb phalanx (HP:0009942)1.99775415
70Patellar aplasia (HP:0006443)1.99680114
71Thrombocytosis (HP:0001894)1.99656455
72Oral leukoplakia (HP:0002745)1.97062630
73High pitched voice (HP:0001620)1.96164831
74Absent hand (HP:0004050)1.94790462
75Duplicated collecting system (HP:0000081)1.94042525
76Seborrheic dermatitis (HP:0001051)1.93500419
77Absent thumb (HP:0009777)1.92617739
78Stridor (HP:0010307)1.92407600
79Right ventricular cardiomyopathy (HP:0011663)1.92201061
80Facial hemangioma (HP:0000329)1.91635970
81Aplasia/Hypoplasia of the patella (HP:0006498)1.91262998
82Porencephaly (HP:0002132)1.90558644
83Myopathic facies (HP:0002058)1.90505023
84Ureteral duplication (HP:0000073)1.89974600
85Vaginal fistula (HP:0004320)1.89878196
86Hypoparathyroidism (HP:0000829)1.89119733
87Intestinal fistula (HP:0100819)1.89108703
88Distal lower limb amyotrophy (HP:0008944)1.87667555
89Ankyloglossia (HP:0010296)1.87356531
90Atresia of the external auditory canal (HP:0000413)1.84989524
91Aplasia/hypoplasia of the humerus (HP:0006507)1.84590293
92Thin ribs (HP:0000883)1.83879196
93Abnormality of the vasculature of the conjunctiva (HP:0008054)1.82943646
94Unilateral renal agenesis (HP:0000122)1.82524706
95Progressive external ophthalmoplegia (HP:0000590)1.82497065
96Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.82454488
97Short 4th metacarpal (HP:0010044)1.82454488
98High anterior hairline (HP:0009890)1.81916113
99Achilles tendon contracture (HP:0001771)1.81682673
100Hyporeflexia of lower limbs (HP:0002600)1.81254938
101Deviation of the thumb (HP:0009603)1.81021984
102Abnormal ventriculo-arterial connection (HP:0011563)1.79820809
103Transposition of the great arteries (HP:0001669)1.79820809
104Abnormal connection of the cardiac segments (HP:0011545)1.79820809
105Absent radius (HP:0003974)1.79178298
106Patellar dislocation (HP:0002999)1.76484553
10711 pairs of ribs (HP:0000878)1.76360956
108Sparse lateral eyebrow (HP:0005338)1.75551706
109Progressive muscle weakness (HP:0003323)1.75386428
110Renal duplication (HP:0000075)1.74942784
111Absent epiphyses (HP:0010577)1.74778971
112Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.74778971
113Degeneration of anterior horn cells (HP:0002398)1.74661344
114Abnormality of the anterior horn cell (HP:0006802)1.74661344
115Long palpebral fissure (HP:0000637)1.74499690
116Abnormality of DNA repair (HP:0003254)1.74145577
117Sparse eyelashes (HP:0000653)1.74083502
118Basal cell carcinoma (HP:0002671)1.74000212
119Proximal placement of thumb (HP:0009623)1.73848840
120Myelodysplasia (HP:0002863)1.73818849
121Abnormal large intestine physiology (HP:0012700)1.73370337
122Shallow orbits (HP:0000586)1.72963362
123Abnormal platelet function (HP:0011869)1.72960292
124Impaired platelet aggregation (HP:0003540)1.72960292
125Osteolytic defects of the phalanges of the hand (HP:0009771)1.72865180
126Osteolytic defects of the hand bones (HP:0009699)1.72865180
127Abnormally folded helix (HP:0008544)1.72816781
128Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.72421964
129Septate vagina (HP:0001153)1.72256940
130Bowel incontinence (HP:0002607)1.71975259
131Self-mutilation (HP:0000742)1.71550668
132Bicuspid aortic valve (HP:0001647)1.71064171
133Morphological abnormality of the inner ear (HP:0011390)1.69831833
134Flared metaphyses (HP:0003015)1.69679936
135Spinal muscular atrophy (HP:0007269)1.69062039
136Abnormality of reticulocytes (HP:0004312)1.68857689
137Abnormal number of incisors (HP:0011064)1.68811857
138Chromsome breakage (HP:0040012)1.68674472
139Abnormal umbilical cord blood vessels (HP:0011403)1.67592120
140Single umbilical artery (HP:0001195)1.67592120
141Abnormality of the fetal cardiovascular system (HP:0010948)1.67592120
142Horseshoe kidney (HP:0000085)1.67393824
143Reduced subcutaneous adipose tissue (HP:0003758)1.67113946
144Microretrognathia (HP:0000308)1.66703519
145Ectopic kidney (HP:0000086)1.66626741
146Small intestinal stenosis (HP:0012848)1.66574192
147Duodenal stenosis (HP:0100867)1.66574192
148Genu recurvatum (HP:0002816)1.66223744
149Biconcave vertebral bodies (HP:0004586)1.66198452
150Nonimmune hydrops fetalis (HP:0001790)1.65744960
151Overlapping toe (HP:0001845)1.64282201
152Calcaneovalgus deformity (HP:0001848)1.63700295
153Aplasia involving forearm bones (HP:0009822)1.63292759
154Absent forearm bone (HP:0003953)1.63292759
155Meckel diverticulum (HP:0002245)1.63183608
156Short humerus (HP:0005792)1.61756457
157Abnormality of the hepatic vasculature (HP:0006707)1.61607447
158Missing ribs (HP:0000921)1.60209304
159Pustule (HP:0200039)1.60061390
160Milia (HP:0001056)1.59883555
161Lipoatrophy (HP:0100578)1.59627568
162Deformed tarsal bones (HP:0008119)1.59247281
163Wrist flexion contracture (HP:0001239)1.59226217
164Slender long bone (HP:0003100)1.58937408
165Metaphyseal cupping (HP:0003021)1.58197835
166Mesangial abnormality (HP:0001966)1.56845866
167Ulnar bowing (HP:0003031)1.56472888

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE14.75228782
2SMG14.21412309
3BUB13.48736989
4WEE13.30554736
5KDR3.16361227
6ICK3.15437280
7PKN23.13312793
8TGFBR12.81479846
9IRAK32.77895811
10NME22.35197381
11VRK22.33358585
12NEK22.25359634
13TTN2.10619792
14TGFBR22.02929730
15MAP2K32.00103051
16CDK121.95719371
17EPHA21.90898510
18MAP3K31.83215214
19CDC71.75601033
20TRIB31.75580120
21CDK71.64875660
22RPS6KB21.57337517
23STK101.56438836
24TTK1.56306545
25PAK41.55427626
26MST1R1.53120471
27PRPF4B1.50188749
28TLK11.46485127
29NEK11.40802329
30SIK11.40628906
31RIPK11.38646048
32FLT31.36970726
33MAP3K111.34356611
34MAP3K81.31092722
35ERN11.29728800
36PLK11.29076196
37AURKB1.25689685
38BRSK21.23597221
39MAP3K101.21297060
40EEF2K1.17826961
41TSSK61.16361659
42EIF2AK11.14738588
43DYRK31.13172040
44MKNK11.12878044
45LRRK21.10970327
46EPHB21.09073564
47BRSK11.07316806
48BRAF1.03678818
49CDK41.03594253
50RPS6KA41.02961085
51VRK10.99900822
52MAP4K10.99360857
53FGFR40.98704039
54PRKD30.98639460
55TAF10.96551961
56MAPK110.96445379
57PASK0.96208785
58STK40.95585992
59PBK0.94625086
60PTK60.91788743
61PIM20.88204840
62MKNK20.88073400
63MAPKAPK30.85960903
64JAK30.84528297
65TESK20.80948261
66TAOK20.80605962
67BRD40.76595484
68PRKG20.75304054
69LATS20.75047061
70CDK60.74211501
71CDK90.74101779
72CHEK20.73179932
73ATR0.72941157
74PAK20.72658918
75CDK80.72438761
76MTOR0.71583160
77STK30.69784226
78SCYL20.69264412
79IRAK20.69109940
80MARK30.67849645
81PAK10.67670990
82NME10.66220609
83PIM10.65569281
84ALK0.65473212
85PLK40.64532353
86AURKA0.63902103
87MAPKAPK50.63848240
88SRPK10.63232393
89MAP2K20.62465582
90BCKDK0.59618457
91PDK20.59103859
92CDK10.58436128
93CHEK10.58406828
94AKT20.58366201
95ILK0.55406822
96DAPK10.54877808
97NEK90.53942934
98DMPK0.53579913
99RPS6KL10.50207747
100RPS6KC10.50207747
101PDPK10.49773983
102CLK10.48260589
103KSR20.47111633
104PLK30.46243434
105ATM0.45860487
106PTK20.45058560
107BTK0.44524878
108CDK20.44202416
109CAMK1D0.43130298
110ZAK0.42903915
111SIK20.42568830
112AKT30.42186258
113BMX0.38765508
114FER0.38495195
115EIF2AK20.38142237
116MELK0.37902865
117GRK10.37632526
118PRKCI0.37316755
119CSNK2A10.37255631
120RPS6KA60.35888239
121PDGFRA0.35830597
122RPS6KA10.35757746
123CCNB10.35750895
124CSF1R0.34713926
125CSK0.34023490
126CDK11A0.33893213
127RPS6KA20.33345124
128DYRK1B0.33323776
129IKBKB0.31915767
130DAPK30.31901787
131EIF2AK30.31779368
132ARAF0.30980996
133PTK2B0.30740580
134MET0.30372055
135MAPK120.30314830
136CSNK2A20.29582497
137TBK10.28170692
138CHUK0.27937746
139PRKD10.27537790

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.97270568
2Ribosome_Homo sapiens_hsa030103.87584733
3Mismatch repair_Homo sapiens_hsa034303.34867197
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.85915269
5Spliceosome_Homo sapiens_hsa030402.63712096
6RNA transport_Homo sapiens_hsa030132.55148493
7Cell cycle_Homo sapiens_hsa041102.49899211
8Base excision repair_Homo sapiens_hsa034102.45217062
9RNA polymerase_Homo sapiens_hsa030202.42879228
10Homologous recombination_Homo sapiens_hsa034402.32373081
11Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.03019198
12Nucleotide excision repair_Homo sapiens_hsa034201.98301660
13One carbon pool by folate_Homo sapiens_hsa006701.74464421
14Pyrimidine metabolism_Homo sapiens_hsa002401.70276261
15p53 signaling pathway_Homo sapiens_hsa041151.64456623
16Small cell lung cancer_Homo sapiens_hsa052221.58314554
17Proteasome_Homo sapiens_hsa030501.55505712
18Fanconi anemia pathway_Homo sapiens_hsa034601.51175572
19Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.40075608
20Fructose and mannose metabolism_Homo sapiens_hsa000511.38276114
21RNA degradation_Homo sapiens_hsa030181.29107621
22mRNA surveillance pathway_Homo sapiens_hsa030151.28168234
23ECM-receptor interaction_Homo sapiens_hsa045121.28083003
24Non-small cell lung cancer_Homo sapiens_hsa052231.26636449
25Notch signaling pathway_Homo sapiens_hsa043301.18547231
26Cysteine and methionine metabolism_Homo sapiens_hsa002701.18350341
27Pancreatic cancer_Homo sapiens_hsa052121.17435117
28MicroRNAs in cancer_Homo sapiens_hsa052061.16889032
29Epstein-Barr virus infection_Homo sapiens_hsa051691.16493240
30HTLV-I infection_Homo sapiens_hsa051661.14975800
31Leukocyte transendothelial migration_Homo sapiens_hsa046701.13920131
32Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.13566351
33Herpes simplex infection_Homo sapiens_hsa051681.13289435
34Thyroid cancer_Homo sapiens_hsa052161.12546472
35Focal adhesion_Homo sapiens_hsa045101.07688134
36Shigellosis_Homo sapiens_hsa051311.06396171
37Non-homologous end-joining_Homo sapiens_hsa034501.05122849
38Viral carcinogenesis_Homo sapiens_hsa052031.04204918
39Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.03493942
40Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.03441966
41Basal transcription factors_Homo sapiens_hsa030221.00662884
42Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.99980781
43AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.99224002
44Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.98245448
45Pyruvate metabolism_Homo sapiens_hsa006200.97744081
46Adherens junction_Homo sapiens_hsa045200.95889065
47Chronic myeloid leukemia_Homo sapiens_hsa052200.94072630
48Acute myeloid leukemia_Homo sapiens_hsa052210.91690531
49TGF-beta signaling pathway_Homo sapiens_hsa043500.91155195
50HIF-1 signaling pathway_Homo sapiens_hsa040660.91056293
51Transcriptional misregulation in cancer_Homo sapiens_hsa052020.89854502
52Basal cell carcinoma_Homo sapiens_hsa052170.89702474
53Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.88311381
54Cyanoamino acid metabolism_Homo sapiens_hsa004600.86861742
55Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.86796109
56Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.85587209
57Apoptosis_Homo sapiens_hsa042100.85083465
58Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.83666425
59Other glycan degradation_Homo sapiens_hsa005110.80626530
60Purine metabolism_Homo sapiens_hsa002300.80375227
61Viral myocarditis_Homo sapiens_hsa054160.79902588
62Proteoglycans in cancer_Homo sapiens_hsa052050.79866081
63Glioma_Homo sapiens_hsa052140.77647777
64N-Glycan biosynthesis_Homo sapiens_hsa005100.77582023
65Hippo signaling pathway_Homo sapiens_hsa043900.77557006
66Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.77511669
67Selenocompound metabolism_Homo sapiens_hsa004500.77354169
68Pathways in cancer_Homo sapiens_hsa052000.76559450
69Bladder cancer_Homo sapiens_hsa052190.76371081
70Arginine biosynthesis_Homo sapiens_hsa002200.75975934
71Longevity regulating pathway - mammal_Homo sapiens_hsa042110.74392092
72Legionellosis_Homo sapiens_hsa051340.74299937
73Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.73495147
74Platelet activation_Homo sapiens_hsa046110.73045035
75Oocyte meiosis_Homo sapiens_hsa041140.72790013
76Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.69770205
77* PI3K-Akt signaling pathway_Homo sapiens_hsa041510.69622321
78Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.68822523
79Toxoplasmosis_Homo sapiens_hsa051450.67617553
80Central carbon metabolism in cancer_Homo sapiens_hsa052300.66793737
81Tight junction_Homo sapiens_hsa045300.66602914
82Antigen processing and presentation_Homo sapiens_hsa046120.66263564
83Folate biosynthesis_Homo sapiens_hsa007900.66057312
84Biosynthesis of amino acids_Homo sapiens_hsa012300.65393982
85NF-kappa B signaling pathway_Homo sapiens_hsa040640.64687462
86Colorectal cancer_Homo sapiens_hsa052100.62497175
87Systemic lupus erythematosus_Homo sapiens_hsa053220.62459526
88Hepatitis B_Homo sapiens_hsa051610.61176889
89Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.60770686
90Hematopoietic cell lineage_Homo sapiens_hsa046400.60338838
91AMPK signaling pathway_Homo sapiens_hsa041520.59794457
92Pentose phosphate pathway_Homo sapiens_hsa000300.59656274
93TNF signaling pathway_Homo sapiens_hsa046680.59289773
94Regulation of actin cytoskeleton_Homo sapiens_hsa048100.58372486
95Insulin signaling pathway_Homo sapiens_hsa049100.58281220
96Sulfur relay system_Homo sapiens_hsa041220.57899838
97Measles_Homo sapiens_hsa051620.57156772
98Dilated cardiomyopathy_Homo sapiens_hsa054140.56430740
99Hedgehog signaling pathway_Homo sapiens_hsa043400.55911746
100Prion diseases_Homo sapiens_hsa050200.55535737
101Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.55477002
102Thyroid hormone signaling pathway_Homo sapiens_hsa049190.55192699
103Caffeine metabolism_Homo sapiens_hsa002320.54286700
104Leishmaniasis_Homo sapiens_hsa051400.53792470
105Influenza A_Homo sapiens_hsa051640.53174955
106Alcoholism_Homo sapiens_hsa050340.52847923
107Malaria_Homo sapiens_hsa051440.52475200
108Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.52179369
109Galactose metabolism_Homo sapiens_hsa000520.50833830
110Amoebiasis_Homo sapiens_hsa051460.50688578
111Endometrial cancer_Homo sapiens_hsa052130.50588622
112Jak-STAT signaling pathway_Homo sapiens_hsa046300.50050216
113Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.49398187
114Vitamin B6 metabolism_Homo sapiens_hsa007500.47349095
115VEGF signaling pathway_Homo sapiens_hsa043700.47171171
116Carbon metabolism_Homo sapiens_hsa012000.46815136
117Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.46557067
118RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.46009296
119Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.43897870
120NOD-like receptor signaling pathway_Homo sapiens_hsa046210.43617136
121Prostate cancer_Homo sapiens_hsa052150.43510134
122Melanoma_Homo sapiens_hsa052180.43479306
123Glutathione metabolism_Homo sapiens_hsa004800.42232206
124Renal cell carcinoma_Homo sapiens_hsa052110.42073372
125mTOR signaling pathway_Homo sapiens_hsa041500.42005008
126B cell receptor signaling pathway_Homo sapiens_hsa046620.41575650
127Rap1 signaling pathway_Homo sapiens_hsa040150.40733958
128Lysine degradation_Homo sapiens_hsa003100.40452818
1292-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.40305430
130Neurotrophin signaling pathway_Homo sapiens_hsa047220.39950291
131ErbB signaling pathway_Homo sapiens_hsa040120.38660702
132Hepatitis C_Homo sapiens_hsa051600.37829631
133Arginine and proline metabolism_Homo sapiens_hsa003300.36414235
134Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.34895268
135Phenylalanine metabolism_Homo sapiens_hsa003600.32292959
136Adipocytokine signaling pathway_Homo sapiens_hsa049200.30490701

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