PKNOX1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)5.90852206
2L-fucose catabolic process (GO:0042355)4.03198285
3fucose catabolic process (GO:0019317)4.03198285
4L-fucose metabolic process (GO:0042354)4.03198285
5response to pheromone (GO:0019236)3.98403949
6positive regulation of gamma-delta T cell activation (GO:0046645)3.95777218
7negative regulation of telomere maintenance (GO:0032205)3.77943181
8protein localization to kinetochore (GO:0034501)3.77770032
9interferon-gamma secretion (GO:0072643)3.75409191
10kynurenine metabolic process (GO:0070189)3.75156625
11water-soluble vitamin biosynthetic process (GO:0042364)3.73432083
12indolalkylamine metabolic process (GO:0006586)3.67082224
13detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.66879512
14indole-containing compound catabolic process (GO:0042436)3.66205711
15indolalkylamine catabolic process (GO:0046218)3.66205711
16tryptophan catabolic process (GO:0006569)3.66205711
17protein localization to chromosome, centromeric region (GO:0071459)3.41456500
18tryptophan metabolic process (GO:0006568)3.35357866
19nuclear pore organization (GO:0006999)3.32029605
20protein-cofactor linkage (GO:0018065)3.31788407
21piRNA metabolic process (GO:0034587)3.30393657
22nuclear pore complex assembly (GO:0051292)3.28751974
23behavioral response to ethanol (GO:0048149)3.24880443
24epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.23194430
25adaptation of signaling pathway (GO:0023058)3.23193376
26antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.22010598
27antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.22010598
28replication fork processing (GO:0031297)3.21421386
29protein polyglutamylation (GO:0018095)3.21348696
30mitotic nuclear envelope disassembly (GO:0007077)3.21115638
31regulation of gamma-delta T cell differentiation (GO:0045586)3.20050482
32nucleobase biosynthetic process (GO:0046112)3.19768420
33DNA strand elongation involved in DNA replication (GO:0006271)3.16792607
34purine nucleobase biosynthetic process (GO:0009113)3.16548117
35multicellular organism reproduction (GO:0032504)3.15577486
36interferon-gamma production (GO:0032609)3.15322732
37peptidyl-histidine modification (GO:0018202)3.11731769
38RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.10921015
39detection of light stimulus involved in visual perception (GO:0050908)3.09616684
40detection of light stimulus involved in sensory perception (GO:0050962)3.09616684
41regulation of spindle organization (GO:0090224)3.08866588
42synaptic transmission, cholinergic (GO:0007271)3.07778012
43mitotic metaphase plate congression (GO:0007080)3.07702310
44nonmotile primary cilium assembly (GO:0035058)3.07569900
45telomere maintenance via semi-conservative replication (GO:0032201)3.06774524
46L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.04177188
47DNA strand elongation (GO:0022616)3.03303022
48rRNA catabolic process (GO:0016075)2.99826117
49regulation of gamma-delta T cell activation (GO:0046643)2.99510425
50cellular ketone body metabolic process (GO:0046950)2.97307130
51ubiquinone metabolic process (GO:0006743)2.96763545
52negative regulation of DNA-dependent DNA replication (GO:2000104)2.96336657
53regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.95558083
54attachment of spindle microtubules to kinetochore (GO:0008608)2.94840868
55telomere maintenance via recombination (GO:0000722)2.94648015
56membrane disassembly (GO:0030397)2.94201326
57nuclear envelope disassembly (GO:0051081)2.94201326
58negative T cell selection (GO:0043383)2.94167902
59DNA replication checkpoint (GO:0000076)2.93406191
60kidney morphogenesis (GO:0060993)2.92958160
61platelet dense granule organization (GO:0060155)2.92066590
62regulation of action potential (GO:0098900)2.92015206
63negative regulation of mast cell activation (GO:0033004)2.91485574
64regulation of telomere maintenance (GO:0032204)2.91401986
65pseudouridine synthesis (GO:0001522)2.91384360
66mitotic recombination (GO:0006312)2.90341201
67regulation of rhodopsin mediated signaling pathway (GO:0022400)2.89593998
68regulation of nuclear cell cycle DNA replication (GO:0033262)2.88849594
69startle response (GO:0001964)2.87524802
70antigen processing and presentation of endogenous antigen (GO:0019883)2.86935158
71regulation of interleukin-12 biosynthetic process (GO:0045075)2.86831556
72DNA unwinding involved in DNA replication (GO:0006268)2.86256189
73ubiquinone biosynthetic process (GO:0006744)2.85726407
74DNA replication-independent nucleosome organization (GO:0034724)2.84502718
75DNA replication-independent nucleosome assembly (GO:0006336)2.84502718
76mitotic chromosome condensation (GO:0007076)2.84353571
77indole-containing compound metabolic process (GO:0042430)2.84240213
78negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.84239082
79negative regulation of translation, ncRNA-mediated (GO:0040033)2.84239082
80regulation of translation, ncRNA-mediated (GO:0045974)2.84239082
81NADH dehydrogenase complex assembly (GO:0010257)2.83561177
82mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.83561177
83mitochondrial respiratory chain complex I assembly (GO:0032981)2.83561177
84leukocyte aggregation (GO:0070486)2.82642122
85positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.81239615
86protein localization to cilium (GO:0061512)2.80124464
87neural tube formation (GO:0001841)2.79503086
88rhodopsin mediated signaling pathway (GO:0016056)2.78882671
89positive thymic T cell selection (GO:0045059)2.78204354
90CENP-A containing nucleosome assembly (GO:0034080)2.77700378
91protein complex biogenesis (GO:0070271)2.77563732
92pore complex assembly (GO:0046931)2.77535321
93regulation of histone H3-K27 methylation (GO:0061085)2.77470249
94regulation of hexokinase activity (GO:1903299)2.77300403
95regulation of glucokinase activity (GO:0033131)2.77300403
96negative regulation of cytosolic calcium ion concentration (GO:0051481)2.77019403
97ketone body metabolic process (GO:1902224)2.76157219
98negative thymic T cell selection (GO:0045060)2.74713525
99regulation of hippo signaling (GO:0035330)2.74654895
100cornea development in camera-type eye (GO:0061303)2.74536538
101recombinational repair (GO:0000725)2.73618180
102DNA replication initiation (GO:0006270)2.73008530
103DNA double-strand break processing (GO:0000729)2.72994536
104epithelial cilium movement (GO:0003351)2.71945908
105neuronal action potential (GO:0019228)2.71109464
106chromatin remodeling at centromere (GO:0031055)2.71107504
107cilium morphogenesis (GO:0060271)2.70311285
108DNA topological change (GO:0006265)2.70071226
109preassembly of GPI anchor in ER membrane (GO:0016254)2.69569227
110double-strand break repair via homologous recombination (GO:0000724)2.69257452
111respiratory chain complex IV assembly (GO:0008535)2.69074630
112kinetochore organization (GO:0051383)2.67663585
113regulation of acrosome reaction (GO:0060046)2.67528343
114mitochondrial respiratory chain complex assembly (GO:0033108)2.67241070
115negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.66439134
116negative regulation of cell killing (GO:0031342)2.66439134
117amino acid salvage (GO:0043102)2.66396161
118L-methionine salvage (GO:0071267)2.66396161
119L-methionine biosynthetic process (GO:0071265)2.66396161
120folic acid metabolic process (GO:0046655)2.65326617
121nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.65065489
122regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.64350975
123regulation of cilium movement (GO:0003352)2.63968259
124histone mRNA catabolic process (GO:0071044)2.62757914
125monoubiquitinated protein deubiquitination (GO:0035520)2.62085222
126folic acid-containing compound biosynthetic process (GO:0009396)2.61750030
127translesion synthesis (GO:0019985)2.61629852
128positive regulation of chromosome segregation (GO:0051984)2.61576085
129mitotic sister chromatid cohesion (GO:0007064)2.61516937
130exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.61495031
131metaphase plate congression (GO:0051310)2.61030948
132regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.60918742
133negative regulation of transcription regulatory region DNA binding (GO:2000678)2.60570037
134cellular response to ATP (GO:0071318)2.59505012
135positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.58985583
136thymic T cell selection (GO:0045061)2.58756572
137protein localization to chromosome (GO:0034502)2.57630643
138regulation of meiosis I (GO:0060631)2.57485526
139formation of translation preinitiation complex (GO:0001731)2.55969458
140histone-serine phosphorylation (GO:0035404)2.54302783
141DNA replication-dependent nucleosome organization (GO:0034723)2.54246417
142DNA replication-dependent nucleosome assembly (GO:0006335)2.54246417
143establishment of chromosome localization (GO:0051303)2.54040604
144IMP biosynthetic process (GO:0006188)2.53021703
145DNA methylation involved in gamete generation (GO:0043046)2.52347586
146regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033392.52329718
147protein prenylation (GO:0018342)2.52155496
148prenylation (GO:0097354)2.52155496
149sister chromatid segregation (GO:0000819)2.52129440
150cilium organization (GO:0044782)2.51452673
151negative regulation by host of viral transcription (GO:0043922)2.51280886
152cellular biogenic amine catabolic process (GO:0042402)2.50198586
153amine catabolic process (GO:0009310)2.50198586
154male meiosis I (GO:0007141)2.50098812
155photoreceptor cell development (GO:0042461)2.49821731
156histone exchange (GO:0043486)2.49568404
157sulfation (GO:0051923)2.49475116
158regulation of posttranscriptional gene silencing (GO:0060147)2.49369208
159regulation of gene silencing by miRNA (GO:0060964)2.49369208
160regulation of gene silencing by RNA (GO:0060966)2.49369208
161T cell selection (GO:0045058)2.49110420
162mannosylation (GO:0097502)2.48775306
163ribosome biogenesis (GO:0042254)2.48742863
164ATP-dependent chromatin remodeling (GO:0043044)2.48196789
165auditory receptor cell stereocilium organization (GO:0060088)2.47224252
166positive T cell selection (GO:0043368)2.47014092
167pyrimidine nucleobase catabolic process (GO:0006208)2.46650021
168DNA deamination (GO:0045006)2.45271392
169nuclear envelope organization (GO:0006998)2.44349628
170mitotic sister chromatid segregation (GO:0000070)2.44306415
171protein K6-linked ubiquitination (GO:0085020)2.43823837
172positive regulation of isotype switching (GO:0045830)2.43107761
173telomere maintenance via telomere lengthening (GO:0010833)2.41201255
174snRNA processing (GO:0016180)2.40915172
175chromosome condensation (GO:0030261)2.40896358
176maturation of SSU-rRNA (GO:0030490)2.39576750
177nucleotide-excision repair, DNA gap filling (GO:0006297)2.39165543
178rRNA modification (GO:0000154)2.38046330
179regulation of double-strand break repair via homologous recombination (GO:0010569)2.38002515
180Arp2/3 complex-mediated actin nucleation (GO:0034314)2.37699194
181hepatocyte apoptotic process (GO:0097284)2.34432828
182maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.33829952
183dosage compensation (GO:0007549)2.33777557
184spindle checkpoint (GO:0031577)2.33513060
185DNA duplex unwinding (GO:0032508)2.32930519
186DNA packaging (GO:0006323)2.31394142
187positive regulation of B cell differentiation (GO:0045579)2.31219784
188histone H2A acetylation (GO:0043968)2.30858019
189chromatin assembly or disassembly (GO:0006333)2.30435787
190DNA geometric change (GO:0032392)2.30052183
191regulation of chromosome segregation (GO:0051983)2.28842436
192snRNA metabolic process (GO:0016073)2.28672266
193telomere maintenance (GO:0000723)2.28165681
194DNA conformation change (GO:0071103)2.27316626
195telomere organization (GO:0032200)2.26975508

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.70714118
2FOXM1_23109430_ChIP-Seq_U2OS_Human3.94715237
3ZNF274_21170338_ChIP-Seq_K562_Hela3.65831049
4GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.33657185
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.09678122
6VDR_22108803_ChIP-Seq_LS180_Human2.96938614
7GBX2_23144817_ChIP-Seq_PC3_Human2.91958070
8EZH2_22144423_ChIP-Seq_EOC_Human2.79429819
9FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.75783057
10MYC_22102868_ChIP-Seq_BL_Human2.68141801
11MYC_18555785_ChIP-Seq_MESCs_Mouse2.58529071
12ZFP57_27257070_Chip-Seq_ESCs_Mouse2.58034004
13GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.54186016
14EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.44959411
15EGR1_19374776_ChIP-ChIP_THP-1_Human2.41449281
16ELF1_17652178_ChIP-ChIP_JURKAT_Human2.40451250
17MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.35542280
18POU3F2_20337985_ChIP-ChIP_501MEL_Human2.26181637
19CTBP2_25329375_ChIP-Seq_LNCAP_Human2.14389389
20FUS_26573619_Chip-Seq_HEK293_Human2.13440606
21TAF15_26573619_Chip-Seq_HEK293_Human2.11562477
22TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.11129231
23SALL1_21062744_ChIP-ChIP_HESCs_Human2.10900141
24IRF8_22096565_ChIP-ChIP_GC-B_Human2.09016800
25P300_19829295_ChIP-Seq_ESCs_Human2.08369955
26SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.08065370
27IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.07578767
28CTBP1_25329375_ChIP-Seq_LNCAP_Human2.07284786
29FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.06648953
30RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.06493785
31SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.06249843
32IGF1R_20145208_ChIP-Seq_DFB_Human2.04734177
33EST1_17652178_ChIP-ChIP_JURKAT_Human2.02325289
34VDR_23849224_ChIP-Seq_CD4+_Human2.00988986
35STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.99414067
36EWS_26573619_Chip-Seq_HEK293_Human1.98722023
37KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.94749565
38JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.93786111
39MYC_19030024_ChIP-ChIP_MESCs_Mouse1.92895611
40E2F1_21310950_ChIP-Seq_MCF-7_Human1.92198105
41FLI1_27457419_Chip-Seq_LIVER_Mouse1.91880577
42MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.91749655
43CREB1_15753290_ChIP-ChIP_HEK293T_Human1.90669516
44GABP_17652178_ChIP-ChIP_JURKAT_Human1.90009459
45CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.88118015
46ETS1_20019798_ChIP-Seq_JURKAT_Human1.85432310
47MYC_19079543_ChIP-ChIP_MESCs_Mouse1.81737756
48CIITA_25753668_ChIP-Seq_RAJI_Human1.81407459
49MYC_18358816_ChIP-ChIP_MESCs_Mouse1.80677527
50FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.79557076
51NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.79323612
52ER_23166858_ChIP-Seq_MCF-7_Human1.75975904
53* FOXP3_21729870_ChIP-Seq_TREG_Human1.75975719
54AR_21909140_ChIP-Seq_LNCAP_Human1.73526582
55EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.71415430
56ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.70641280
57AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.70085142
58VDR_21846776_ChIP-Seq_THP-1_Human1.70049534
59MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.69468272
60MYB_26560356_Chip-Seq_TH2_Human1.68731105
61NELFA_20434984_ChIP-Seq_ESCs_Mouse1.68567557
62PCGF2_27294783_Chip-Seq_ESCs_Mouse1.67220305
63IRF1_19129219_ChIP-ChIP_H3396_Human1.64614356
64XRN2_22483619_ChIP-Seq_HELA_Human1.63303507
65MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.63026293
66CBP_20019798_ChIP-Seq_JUKART_Human1.62989202
67IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.62989202
68TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.62213275
69POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.62213275
70SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.61978797
71TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.61620474
72KDM5A_27292631_Chip-Seq_BREAST_Human1.61504162
73SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.61351818
74UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.60078729
75BCAT_22108803_ChIP-Seq_LS180_Human1.56531294
76SPI1_23547873_ChIP-Seq_NB4_Human1.56094565
77STAT3_23295773_ChIP-Seq_U87_Human1.55685300
78TP53_22573176_ChIP-Seq_HFKS_Human1.54067605
79DCP1A_22483619_ChIP-Seq_HELA_Human1.53664968
80HOXB4_20404135_ChIP-ChIP_EML_Mouse1.53351709
81IRF8_21731497_ChIP-ChIP_J774_Mouse1.53100931
82FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.52244106
83MYCN_18555785_ChIP-Seq_MESCs_Mouse1.51496598
84MYB_26560356_Chip-Seq_TH1_Human1.50936569
85MAF_26560356_Chip-Seq_TH1_Human1.50248896
86KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.50005123
87PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.49490906
88TP63_19390658_ChIP-ChIP_HaCaT_Human1.48493991
89STAT4_19710469_ChIP-ChIP_TH1__Mouse1.48453171
90GABP_19822575_ChIP-Seq_HepG2_Human1.48263062
91TCF4_23295773_ChIP-Seq_U87_Human1.47900357
92PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.47819294
93SMAD4_21799915_ChIP-Seq_A2780_Human1.47466732
94NOTCH1_21737748_ChIP-Seq_TLL_Human1.46833411
95PIAS1_25552417_ChIP-Seq_VCAP_Human1.45686335
96MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.44798364
97MYB_21317192_ChIP-Seq_ERMYB_Mouse1.43825739
98FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.43490868
99* AR_25329375_ChIP-Seq_VCAP_Human1.42980056
100PCGF2_27294783_Chip-Seq_NPCs_Mouse1.42224006
101UTX_26944678_Chip-Seq_JUKART_Human1.42137983
102* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.40546110
103SCL_19346495_ChIP-Seq_HPC-7_Human1.37666685
104FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.37429558
105SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.36729244
106CBX2_27304074_Chip-Seq_ESCs_Mouse1.34641989
107* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.33761188
108STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.33438248
109BMI1_23680149_ChIP-Seq_NPCS_Mouse1.32873065
110GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.32055608
111ELK1_19687146_ChIP-ChIP_HELA_Human1.31391303
112FLI1_21867929_ChIP-Seq_TH2_Mouse1.30465040
113CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.29942315
114NANOG_19829295_ChIP-Seq_ESCs_Human1.29812283
115SOX2_19829295_ChIP-Seq_ESCs_Human1.29812283
116RUNX_20019798_ChIP-Seq_JUKART_Human1.29320650
117TCF4_22108803_ChIP-Seq_LS180_Human1.28845704
118HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.27528252
119SMAD3_21741376_ChIP-Seq_EPCs_Human1.27182012
120MYC_18940864_ChIP-ChIP_HL60_Human1.26727881
121* RUNX1_22412390_ChIP-Seq_EML_Mouse1.26618906
122MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.26563339
123EZH2_27294783_Chip-Seq_NPCs_Mouse1.25892308
124SUZ12_27294783_Chip-Seq_NPCs_Mouse1.25595969
125* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.25099765
126KLF5_20875108_ChIP-Seq_MESCs_Mouse1.24625501
127TOP2B_26459242_ChIP-Seq_MCF-7_Human1.23155137
128RNF2_27304074_Chip-Seq_NSC_Mouse1.22705159
129SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.22495139
130NFE2_27457419_Chip-Seq_LIVER_Mouse1.21957276
131NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.21730104
132POU5F1_16153702_ChIP-ChIP_HESCs_Human1.21245544
133REST_21632747_ChIP-Seq_MESCs_Mouse1.20572838
134* RUNX2_22187159_ChIP-Seq_PCA_Human1.20387328
135MAF_26560356_Chip-Seq_TH2_Human1.17210187
136SMAD4_21741376_ChIP-Seq_EPCs_Human1.17020670
137* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.16479520
138YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.15847310
139OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.15251435
140TCF7_22412390_ChIP-Seq_EML_Mouse1.15109705
141PRDM14_20953172_ChIP-Seq_ESCs_Human1.15069000
142TFEB_21752829_ChIP-Seq_HELA_Human1.14890421
143* TTF2_22483619_ChIP-Seq_HELA_Human1.14078075
144EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.12628598
145ETV2_25802403_ChIP-Seq_MESCs_Mouse1.12262722
146FOXA1_27270436_Chip-Seq_PROSTATE_Human1.12183934
147FOXA1_25329375_ChIP-Seq_VCAP_Human1.12183934
148* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.11805981
149* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.11580112
150NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.11552466
151CRX_20693478_ChIP-Seq_RETINA_Mouse1.11546282
152CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.09801718
153E2F1_18555785_ChIP-Seq_MESCs_Mouse1.09744336
154E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.09123120
155NANOG_18555785_ChIP-Seq_MESCs_Mouse1.07653173
156* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.07136087
157NCOR_22424771_ChIP-Seq_293T_Human1.07023033
158NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.06535417
159TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.06503161
160NANOG_18555785_Chip-Seq_ESCs_Mouse1.05232675
161VDR_24763502_ChIP-Seq_THP-1_Human1.04202300
162ZFX_18555785_ChIP-Seq_MESCs_Mouse1.03902976
163DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.03878997
164FOXA1_21572438_ChIP-Seq_LNCaP_Human1.03513021
165IRF8_27001747_Chip-Seq_BMDM_Mouse1.03145963
166AR_20517297_ChIP-Seq_VCAP_Human1.02780040
167* HOXB7_26014856_ChIP-Seq_BT474_Human1.02691761
168TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.02197593
169* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.01995035
170* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.01664306
171GATA3_21878914_ChIP-Seq_MCF-7_Human1.01512444
172AUTS2_25519132_ChIP-Seq_293T-REX_Human1.01145164
173KLF4_18555785_ChIP-Seq_MESCs_Mouse1.00624332
174CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.00536685
175CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.00173363
176EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.99590224
177P53_22387025_ChIP-Seq_ESCs_Mouse0.99407785
178TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.99311114
179IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.99267882
180TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.98424901
181BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.98327595
182E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.98297849
183PADI4_21655091_ChIP-ChIP_MCF-7_Human0.98295359
184GATA1_22025678_ChIP-Seq_K562_Human0.97293568
185SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.97275057
186* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.97008215
187ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.96606754
188THAP11_20581084_ChIP-Seq_MESCs_Mouse0.96453497
189DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.96080275
190HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.94979895
191KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.94978664
192TP53_16413492_ChIP-PET_HCT116_Human0.94593152

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.04836136
2MP0008057_abnormal_DNA_replication3.66204985
3MP0002102_abnormal_ear_morphology3.54636189
4MP0003195_calcinosis3.24568767
5MP0003763_abnormal_thymus_physiology3.03768579
6MP0003111_abnormal_nucleus_morphology3.00924014
7MP0010094_abnormal_chromosome_stability2.89798664
8MP0002396_abnormal_hematopoietic_system2.76623186
9MP0003077_abnormal_cell_cycle2.69227595
10MP0005551_abnormal_eye_electrophysiolog2.66115258
11MP0003787_abnormal_imprinting2.56829734
12MP0001968_abnormal_touch/_nociception2.50214416
13MP0005671_abnormal_response_to2.40726583
14MP0004957_abnormal_blastocyst_morpholog2.37610133
15MP0003646_muscle_fatigue2.34679272
16MP0005646_abnormal_pituitary_gland2.30569167
17MP0008058_abnormal_DNA_repair2.25387383
18MP0002736_abnormal_nociception_after2.20691936
19MP0002638_abnormal_pupillary_reflex2.20581327
20MP0000372_irregular_coat_pigmentation2.19572627
21MP0001835_abnormal_antigen_presentation2.15595911
22MP0009333_abnormal_splenocyte_physiolog2.11180436
23MP0001800_abnormal_humoral_immune2.08311346
24* MP0002398_abnormal_bone_marrow2.05143970
25MP0010352_gastrointestinal_tract_polyps2.01324176
26MP0008007_abnormal_cellular_replicative2.01142451
27MP0009046_muscle_twitch2.00717031
28MP0001986_abnormal_taste_sensitivity1.96313150
29MP0002837_dystrophic_cardiac_calcinosis1.92144181
30MP0004885_abnormal_endolymph1.85862478
31* MP0000703_abnormal_thymus_morphology1.85410995
32MP0004133_heterotaxia1.85306158
33MP0004808_abnormal_hematopoietic_stem1.81256113
34MP0004043_abnormal_pH_regulation1.80732981
35MP0006072_abnormal_retinal_apoptosis1.78662863
36MP0009745_abnormal_behavioral_response1.77992625
37MP0005253_abnormal_eye_physiology1.77901619
38* MP0002420_abnormal_adaptive_immunity1.77580419
39MP0002876_abnormal_thyroid_physiology1.77236244
40MP0004142_abnormal_muscle_tone1.77059107
41MP0000569_abnormal_digit_pigmentation1.77018392
42MP0002452_abnormal_antigen_presenting1.76804230
43MP0000689_abnormal_spleen_morphology1.76587780
44* MP0001819_abnormal_immune_cell1.75976780
45MP0000490_abnormal_crypts_of1.75899199
46* MP0002722_abnormal_immune_system1.74596998
47MP0002723_abnormal_immune_serum1.73989879
48MP0005000_abnormal_immune_tolerance1.69520506
49MP0001485_abnormal_pinna_reflex1.67503302
50* MP0000716_abnormal_immune_system1.67347357
51MP0006292_abnormal_olfactory_placode1.66949024
52MP0008872_abnormal_physiological_respon1.65311513
53MP0002163_abnormal_gland_morphology1.64303630
54MP0000685_abnormal_immune_system1.63068386
55MP0002938_white_spotting1.62018720
56MP0002272_abnormal_nervous_system1.61336141
57MP0002405_respiratory_system_inflammati1.59618257
58MP0005397_hematopoietic_system_phenotyp1.58542059
59MP0001545_abnormal_hematopoietic_system1.58542059
60MP0001790_abnormal_immune_system1.58062311
61MP0005387_immune_system_phenotype1.58062311
62MP0009785_altered_susceptibility_to1.58058764
63MP0010307_abnormal_tumor_latency1.56475069
64MP0003436_decreased_susceptibility_to1.56136161
65MP0000427_abnormal_hair_cycle1.56064423
66MP0005075_abnormal_melanosome_morpholog1.54985960
67* MP0002429_abnormal_blood_cell1.54146272
68MP0001501_abnormal_sleep_pattern1.54083974
69MP0003121_genomic_imprinting1.52866505
70MP0002735_abnormal_chemical_nociception1.50616688
71MP0004145_abnormal_muscle_electrophysio1.47247997
72MP0005025_abnormal_response_to1.46198572
73MP0001984_abnormal_olfaction1.44990121
74MP0001853_heart_inflammation1.44982863
75MP0008877_abnormal_DNA_methylation1.44167576
76MP0000631_abnormal_neuroendocrine_gland1.43652347
77MP0002132_abnormal_respiratory_system1.43648117
78MP0000350_abnormal_cell_proliferation1.43605643
79MP0006276_abnormal_autonomic_nervous1.40790204
80MP0001730_embryonic_growth_arrest1.40116319
81MP0002019_abnormal_tumor_incidence1.39623726
82MP0004381_abnormal_hair_follicle1.37210874
83MP0003303_peritoneal_inflammation1.36592233
84MP0003866_abnormal_defecation1.35378345
85MP0003283_abnormal_digestive_organ1.35321570
86MP0002928_abnormal_bile_duct1.34853118
87MP0003136_yellow_coat_color1.34623225
88MP0005645_abnormal_hypothalamus_physiol1.33671755
89MP0002166_altered_tumor_susceptibility1.33635440
90MP0001486_abnormal_startle_reflex1.32910118
91MP0010155_abnormal_intestine_physiology1.32767888
92MP0002234_abnormal_pharynx_morphology1.32310701
93MP0002419_abnormal_innate_immunity1.28666985
94MP0000383_abnormal_hair_follicle1.28548497
95MP0000858_altered_metastatic_potential1.26708794
96MP0002006_tumorigenesis1.26211074
97MP0002653_abnormal_ependyma_morphology1.25602201
98MP0002277_abnormal_respiratory_mucosa1.23177329
99MP0005076_abnormal_cell_differentiation1.21782784
100MP0002572_abnormal_emotion/affect_behav1.20533397
101MP0009278_abnormal_bone_marrow1.20045382
102MP0005379_endocrine/exocrine_gland_phen1.19238262
103MP0006082_CNS_inflammation1.17049332
104MP0002733_abnormal_thermal_nociception1.15813821
105MP0004742_abnormal_vestibular_system1.14115415
106MP0003890_abnormal_embryonic-extraembry1.14080879
107MP0003300_gastrointestinal_ulcer1.12937917
108MP0002148_abnormal_hypersensitivity_rea1.12401073
109MP0002557_abnormal_social/conspecific_i1.12252706
110MP0000313_abnormal_cell_death1.11926374
111MP0008932_abnormal_embryonic_tissue1.11899744
112MP0002067_abnormal_sensory_capabilities1.11485308
113MP0005389_reproductive_system_phenotype1.09777989
114MP0001188_hyperpigmentation1.09642283
115MP0000049_abnormal_middle_ear1.09565776
116MP0002751_abnormal_autonomic_nervous1.08620163
117* MP0005380_embryogenesis_phenotype1.08260726
118* MP0001672_abnormal_embryogenesis/_devel1.08260726
119MP0009697_abnormal_copulation1.08090098
120MP0010386_abnormal_urinary_bladder1.06855827
121MP0003880_abnormal_central_pattern1.06145596
122* MP0005195_abnormal_posterior_eye1.05921428
123MP0001845_abnormal_inflammatory_respons1.05766708
124MP0001970_abnormal_pain_threshold1.03887606
125MP0005174_abnormal_tail_pigmentation1.03095322
126MP0004147_increased_porphyrin_level1.02534423
127MP0003718_maternal_effect1.02520239
128MP0005464_abnormal_platelet_physiology1.02090850
129MP0004947_skin_inflammation1.01725355
130* MP0001697_abnormal_embryo_size1.00663118
131MP0002064_seizures1.00607610
132MP0002752_abnormal_somatic_nervous1.00045783
133* MP0002088_abnormal_embryonic_growth/wei0.99769466
134* MP0003984_embryonic_growth_retardation0.99634110
135MP0002933_joint_inflammation0.99413534
136MP0000026_abnormal_inner_ear0.98502991
137MP0000647_abnormal_sebaceous_gland0.98072629
138MP0003937_abnormal_limbs/digits/tail_de0.98015665
139MP0000465_gastrointestinal_hemorrhage0.98013938
140* MP0002080_prenatal_lethality0.97918125
141MP0005386_behavior/neurological_phenoty0.97887489
142MP0004924_abnormal_behavior0.97887489
143MP0009672_abnormal_birth_weight0.97295107
144MP0002184_abnormal_innervation0.97254371
145MP0008875_abnormal_xenobiotic_pharmacok0.96628351
146MP0003806_abnormal_nucleotide_metabolis0.96032388
147MP0008995_early_reproductive_senescence0.95694810
148MP0009840_abnormal_foam_cell0.95354745
149MP0003448_altered_tumor_morphology0.95042323
150* MP0001324_abnormal_eye_pigmentation0.94689192
151MP0002877_abnormal_melanocyte_morpholog0.94409906
152MP0001963_abnormal_hearing_physiology0.94213468
153* MP0002086_abnormal_extraembryonic_tissu0.93842502
154MP0003950_abnormal_plasma_membrane0.92703055
155MP0001919_abnormal_reproductive_system0.90309053
156MP0003635_abnormal_synaptic_transmissio0.89604083
157MP0003786_premature_aging0.88919228
158MP0005310_abnormal_salivary_gland0.88350334
159MP0003011_delayed_dark_adaptation0.87429873
160MP0002229_neurodegeneration0.85939763
161MP0002734_abnormal_mechanical_nocicepti0.85518342
162MP0002138_abnormal_hepatobiliary_system0.85143404
163MP0000015_abnormal_ear_pigmentation0.83991176
164MP0004215_abnormal_myocardial_fiber0.83953188
165MP0005084_abnormal_gallbladder_morpholo0.83797626
166MP0002160_abnormal_reproductive_system0.83749998
167MP0008789_abnormal_olfactory_epithelium0.83239257
168MP0003698_abnormal_male_reproductive0.82984831
169MP0001929_abnormal_gametogenesis0.82507245
170MP0001293_anophthalmia0.82465258
171MP0000778_abnormal_nervous_system0.82447485
172MP0004264_abnormal_extraembryonic_tissu0.82342059
173MP0001529_abnormal_vocalization0.82040368
174MP0003724_increased_susceptibility_to0.81730797
175MP0000371_diluted_coat_color0.79150126
176MP0008469_abnormal_protein_level0.77842083
177MP0002210_abnormal_sex_determination0.77393592
178MP0006054_spinal_hemorrhage0.77337911
179MP0001145_abnormal_male_reproductive0.73912173
180MP0005023_abnormal_wound_healing0.72842856
181MP0010234_abnormal_vibrissa_follicle0.72180758
182MP0001873_stomach_inflammation0.72139804
183MP0005621_abnormal_cell_physiology0.71429996
184* MP0004197_abnormal_fetal_growth/weight/0.71345010
185MP0001533_abnormal_skeleton_physiology0.71315244
186MP0008260_abnormal_autophagy0.70483721
187MP0000477_abnormal_intestine_morphology0.69624206
188* MP0002085_abnormal_embryonic_tissue0.68566822
189MP0003567_abnormal_fetal_cardiomyocyte0.68086701
190MP0000377_abnormal_hair_follicle0.65062371
191MP0001243_abnormal_dermal_layer0.64410632
192MP0002095_abnormal_skin_pigmentation0.62811908

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)4.82315163
2T lymphocytopenia (HP:0005403)4.39957415
3True hermaphroditism (HP:0010459)4.24910422
4Pancreatic fibrosis (HP:0100732)4.22701171
5Abnormality of T cell number (HP:0011839)4.12978598
6Molar tooth sign on MRI (HP:0002419)4.09534261
7Abnormality of midbrain morphology (HP:0002418)4.09534261
8Congenital stationary night blindness (HP:0007642)3.88118119
9Nephronophthisis (HP:0000090)3.78687613
10Recurrent viral infections (HP:0004429)3.52179715
11Abnormality of the fingertips (HP:0001211)3.48567664
12Abnormality of T cells (HP:0002843)3.47971045
13Abnormality of the renal cortex (HP:0011035)3.35680337
14Abnormality of the renal medulla (HP:0100957)3.20070916
15IgM deficiency (HP:0002850)3.19254474
16Severe combined immunodeficiency (HP:0004430)3.18981842
17Type II lissencephaly (HP:0007260)3.17227155
18Combined immunodeficiency (HP:0005387)3.16334705
19Medial flaring of the eyebrow (HP:0010747)3.13914582
20Chronic hepatic failure (HP:0100626)3.01570349
21Recurrent bronchitis (HP:0002837)2.98421240
22Recurrent fungal infections (HP:0002841)2.97225976
23Panhypogammaglobulinemia (HP:0003139)2.94091661
24Tubular atrophy (HP:0000092)2.85133653
25Chronic otitis media (HP:0000389)2.84902092
26Abolished electroretinogram (ERG) (HP:0000550)2.81267996
27Hyperalaninemia (HP:0003348)2.79870132
28Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.79870132
29Abnormality of alanine metabolism (HP:0010916)2.79870132
30Abnormality of T cell physiology (HP:0011840)2.78672108
31Cystic liver disease (HP:0006706)2.77416377
32Polydipsia (HP:0001959)2.73950204
33Abnormal drinking behavior (HP:0030082)2.73950204
34Abnormality of B cell number (HP:0010975)2.73845882
35B lymphocytopenia (HP:0010976)2.73845882
36Birth length less than 3rd percentile (HP:0003561)2.70790578
37Abnormal delayed hypersensitivity skin test (HP:0002963)2.69546628
38Attenuation of retinal blood vessels (HP:0007843)2.66800416
39Elevated erythrocyte sedimentation rate (HP:0003565)2.63514546
40Abnormality of eosinophils (HP:0001879)2.62776549
41Eosinophilia (HP:0001880)2.59946845
42Petechiae (HP:0000967)2.59173282
43Granulocytopenia (HP:0001913)2.55925895
44Lymphoma (HP:0002665)2.55205053
45Abnormal rod and cone electroretinograms (HP:0008323)2.54943150
46Anencephaly (HP:0002323)2.53618595
47Impulsivity (HP:0100710)2.53142410
48Decreased electroretinogram (ERG) amplitude (HP:0000654)2.52769292
49Recurrent abscess formation (HP:0002722)2.52497787
50Eczematoid dermatitis (HP:0000976)2.52201509
51Renal cortical cysts (HP:0000803)2.50544784
52Abnormality of chromosome stability (HP:0003220)2.50379530
53Thyroiditis (HP:0100646)2.50013073
54Gait imbalance (HP:0002141)2.47378876
55IgG deficiency (HP:0004315)2.46795526
56Cerebellar dysplasia (HP:0007033)2.45711110
57Lissencephaly (HP:0001339)2.42185623
58Myelodysplasia (HP:0002863)2.37877897
59Congenital primary aphakia (HP:0007707)2.37626514
60Nephrogenic diabetes insipidus (HP:0009806)2.37535644
61Lymphopenia (HP:0001888)2.36558792
62Abnormality of cells of the lymphoid lineage (HP:0012140)2.35641273
63Abnormality of macular pigmentation (HP:0008002)2.35325627
64Bone marrow hypocellularity (HP:0005528)2.33628252
65Aplasia/Hypoplasia of the tongue (HP:0010295)2.33195129
66Prominent nose (HP:0000448)2.32953411
67Congenital hepatic fibrosis (HP:0002612)2.31879532
68Decreased central vision (HP:0007663)2.31009752
69Increased corneal curvature (HP:0100692)2.30973797
70Keratoconus (HP:0000563)2.30973797
71Sclerocornea (HP:0000647)2.30492080
72Abnormality of the preputium (HP:0100587)2.30144953
73Nasal polyposis (HP:0100582)2.27024356
74Aplasia/Hypoplasia of the uvula (HP:0010293)2.24996074
75Recurrent bacterial skin infections (HP:0005406)2.24730421
76Abnormality of the labia minora (HP:0012880)2.23626723
77Meckel diverticulum (HP:0002245)2.20017153
78Hyperventilation (HP:0002883)2.19928364
79Postaxial foot polydactyly (HP:0001830)2.19453907
80Aplasia/Hypoplasia of the fovea (HP:0008060)2.18957440
81Hypoplasia of the fovea (HP:0007750)2.18957440
82Leukocytosis (HP:0001974)2.18834110
83Chromsome breakage (HP:0040012)2.18191459
84Encephalitis (HP:0002383)2.16282283
85Recurrent sinusitis (HP:0011108)2.15350210
86Pendular nystagmus (HP:0012043)2.14826371
87Aplasia/Hypoplasia of the tibia (HP:0005772)2.14471713
88Chromosomal breakage induced by crosslinking agents (HP:0003221)2.14193054
89Abnormality of the anterior horn cell (HP:0006802)2.14005349
90Degeneration of anterior horn cells (HP:0002398)2.14005349
91Furrowed tongue (HP:0000221)2.13954067
92IgA deficiency (HP:0002720)2.13934180
933-Methylglutaconic aciduria (HP:0003535)2.13651685
94Chorioretinal atrophy (HP:0000533)2.13507567
95Increased CSF lactate (HP:0002490)2.13330373
96Acute necrotizing encephalopathy (HP:0006965)2.13194130
97Thyroid-stimulating hormone excess (HP:0002925)2.12548641
98Bronchitis (HP:0012387)2.12252287
99Meningitis (HP:0001287)2.11514107
100Agammaglobulinemia (HP:0004432)2.10279902
101Progressive inability to walk (HP:0002505)2.09681300
102Polyuria (HP:0000103)2.09245162
103Gaze-evoked nystagmus (HP:0000640)2.08942079
104Patellar aplasia (HP:0006443)2.08618801
105Entropion (HP:0000621)2.07958661
106Ectopic kidney (HP:0000086)2.07623601
107Stomatitis (HP:0010280)2.07201594
108Genital tract atresia (HP:0001827)2.06180989
109Dandy-Walker malformation (HP:0001305)2.04930060
110Inability to walk (HP:0002540)2.04898472
111Pustule (HP:0200039)2.03834436
112Aplasia/Hypoplasia of the patella (HP:0006498)2.03619900
113Vaginal atresia (HP:0000148)2.02798607
114Intestinal atresia (HP:0011100)2.02726100
115Leukopenia (HP:0001882)2.01244450
116Mitochondrial inheritance (HP:0001427)2.01196718
117Pachygyria (HP:0001302)2.00708413
118Abnormality of the ileum (HP:0001549)1.99708825
119Myositis (HP:0100614)1.98499821
120Decreased circulating renin level (HP:0003351)1.97337692
121Recurrent cutaneous fungal infections (HP:0011370)1.96647154
122Chronic mucocutaneous candidiasis (HP:0002728)1.96647154
123Male pseudohermaphroditism (HP:0000037)1.95925637
124Small epiphyses (HP:0010585)1.95597765
125Gastrointestinal inflammation (HP:0004386)1.94786165
126Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.94317397
127Cellulitis (HP:0100658)1.93202377
128Poor coordination (HP:0002370)1.92738589
129Progressive macrocephaly (HP:0004481)1.91378351
130Chronic diarrhea (HP:0002028)1.90798755
131Large for gestational age (HP:0001520)1.90046418
132Clubbing of toes (HP:0100760)1.89889511
133Postaxial hand polydactyly (HP:0001162)1.89622138
134Thrombocytosis (HP:0001894)1.88628890
135Colon cancer (HP:0003003)1.88587095
136Inflammation of the large intestine (HP:0002037)1.88550932
137Hypoplasia of the pons (HP:0012110)1.88312120
138Limb hypertonia (HP:0002509)1.88011452
139Acute myeloid leukemia (HP:0004808)1.87907343
140Abnormality of the pons (HP:0007361)1.87889190
141Abnormal biliary tract physiology (HP:0012439)1.87341525
142Bile duct proliferation (HP:0001408)1.87341525
143Hypoplasia of the thymus (HP:0000778)1.86558536
144Abnormality of the carotid arteries (HP:0005344)1.85992097
145Colitis (HP:0002583)1.85610034
146Spontaneous hematomas (HP:0007420)1.85223444
147Small hand (HP:0200055)1.84735203
148Hypothermia (HP:0002045)1.84210488
149Abnormality of the fovea (HP:0000493)1.83762093
150Broad-based gait (HP:0002136)1.83312180
151Hypomagnesemia (HP:0002917)1.81728421
152Concave nail (HP:0001598)1.81261947
153Sloping forehead (HP:0000340)1.81012027
154Vasculitis (HP:0002633)1.80727924
15511 pairs of ribs (HP:0000878)1.80610686
156Methylmalonic acidemia (HP:0002912)1.79969120
157Poor head control (HP:0002421)1.79372614
158Acute encephalopathy (HP:0006846)1.79205927
159Stomach cancer (HP:0012126)1.78872445
160Dynein arm defect of respiratory motile cilia (HP:0012255)1.78719961
161Absent/shortened dynein arms (HP:0200106)1.78719961
162Absent rod-and cone-mediated responses on ERG (HP:0007688)1.78488189
163Aplasia/Hypoplasia of the thymus (HP:0010515)1.77596463
164Recurrent otitis media (HP:0000403)1.77595679
165Partial agenesis of the corpus callosum (HP:0001338)1.77276867
166Hepatic necrosis (HP:0002605)1.76821174
167Rough bone trabeculation (HP:0100670)1.76568508
168Optic disc pallor (HP:0000543)1.76319191
169Severe muscular hypotonia (HP:0006829)1.75920333
170Increased serum lactate (HP:0002151)1.75784771
171Abnormality of DNA repair (HP:0003254)1.75559412
172Preaxial hand polydactyly (HP:0001177)1.74559262
173Absent thumb (HP:0009777)1.74338296
174Optic nerve hypoplasia (HP:0000609)1.74004216
175Aplastic anemia (HP:0001915)1.73901051
176Methylmalonic aciduria (HP:0012120)1.73366899
177Fair hair (HP:0002286)1.73304602
178Autoimmune thrombocytopenia (HP:0001973)1.73085720
179Thoracolumbar scoliosis (HP:0002944)1.72059311
180Neoplasm of the adrenal cortex (HP:0100641)1.71739483
181Reticulocytopenia (HP:0001896)1.71048239
182Abnormality of the nasal mucosa (HP:0000433)1.70956027
183Occipital encephalocele (HP:0002085)1.70561489
184Hepatocellular necrosis (HP:0001404)1.70050833
185Premature graying of hair (HP:0002216)1.69962567
186Breast hypoplasia (HP:0003187)1.69943262
187Cellular immunodeficiency (HP:0005374)1.68636394
188Oligodactyly (hands) (HP:0001180)1.68590935
189Neoplasm of the pancreas (HP:0002894)1.68461583
190Recurrent skin infections (HP:0001581)1.68142692
191Chronic sinusitis (HP:0011109)1.67907592
192Chronic obstructive pulmonary disease (HP:0006510)1.65526624
193Obstructive lung disease (HP:0006536)1.65526624
194Mediastinal lymphadenopathy (HP:0100721)1.65010078
195Abnormality of macrophages (HP:0004311)1.64278953
196Basal cell carcinoma (HP:0002671)1.63243811
197Hypoplasia of the capital femoral epiphysis (HP:0003090)1.62420360

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.68158724
2MAP4K13.31148953
3ADRBK23.26078578
4TXK2.98398973
5PINK12.95334821
6BMPR1B2.82539502
7MAP4K22.73184214
8NEK22.64129946
9BUB12.47357342
10WEE12.31982412
11GRK12.19176366
12WNK32.09532616
13TAOK32.03684100
14BRD41.99792331
15EPHA21.90414587
16CASK1.89229022
17STK101.84400069
18RPS6KA41.82505818
19TSSK61.81670296
20CDC71.75873273
21MAP3K141.75172077
22MAPK131.72501168
23SRPK11.70167611
24WNK41.69456515
25ZAP701.67943828
26MAP3K101.64776731
27EIF2AK11.62608809
28BRSK21.62055651
29EEF2K1.59406546
30IRAK41.56862399
31CDK121.54678382
32JAK31.53303086
33TRIM281.50280106
34OXSR11.48364294
35DYRK31.47702824
36NLK1.47521270
37TNIK1.47146390
38PIM11.46797150
39STK41.45653664
40NEK91.43156569
41PASK1.42270635
42CDK41.37200293
43PLK41.37198090
44TTK1.33826393
45TRIB31.32235971
46INSRR1.30577825
47CLK11.26479756
48DYRK21.26377725
49ATR1.25750422
50TYK21.25097892
51IRAK31.24228422
52MARK11.23633062
53CHUK1.22989235
54NME21.22106827
55ITK1.21996290
56IRAK11.21398214
57GRK61.19800210
58STK391.19259232
59MAP3K41.17780644
60MKNK21.17145223
61MARK31.15021364
62STK161.13565910
63TEC1.12876241
64PLK11.12806800
65BTK1.11729697
66PLK21.11001818
67ADRBK11.10546146
68EIF2AK31.08451833
69PAK31.08372085
70ZAK1.05781633
71FGFR41.05745644
72DAPK21.05711726
73AURKB1.05549518
74IKBKB1.04683107
75MAP2K31.02433208
76PNCK1.00524410
77IKBKE0.99727882
78TBK10.99465078
79MAP3K30.97891824
80CSNK1G10.97276052
81STK30.94375341
82CDK190.93921920
83CSNK1G20.93627310
84CCNB10.93047072
85MUSK0.93020975
86NTRK30.92797160
87TAF10.92482547
88TESK20.92348388
89MAP3K80.90390312
90RPS6KB20.89744301
91PIM20.89219274
92PRKCG0.89053185
93CSNK1A1L0.88544566
94CSNK1G30.87023239
95PRKCE0.86457515
96BRSK10.85741774
97CHEK10.84309461
98CSK0.83873874
99PLK30.83302885
100MST40.83175927
101CDK70.82783174
102CHEK20.82654352
103TLK10.81502298
104STK38L0.80171358
105TAOK20.79970345
106SIK20.79264375
107TGFBR10.78707088
108VRK20.77748940
109MAP2K70.77725590
110FLT30.76050656
111AKT30.74178679
112BLK0.73201477
113LCK0.72045858
114CSF1R0.71168815
115PKN20.70236447
116MELK0.69610040
117EIF2AK20.67094898
118RIPK10.66350671
119MKNK10.65626848
120RPS6KA50.65020922
121NEK10.64751335
122PHKG10.64048124
123PHKG20.64048124
124ATM0.61819818
125STK110.61231677
126NME10.60532760
127EPHA30.60297540
128FGFR20.59899117
129TIE10.59558623
130CDK90.59280432
131OBSCN0.59189392
132SYK0.59186815
133FGFR30.59149958
134CDK60.58981209
135JAK10.58853341
136HCK0.58543122
137CDK20.57701902
138PDK20.56564156
139ERBB30.56078912
140VRK10.53329157
141MAP2K60.52823556
142LYN0.51738199
143ALK0.51145427
144CDK30.51124307
145MAPKAPK50.49829041
146ERN10.49110106
147PRKCH0.48346448
148NTRK20.47751308
149ACVR1B0.47051268
150PTK2B0.46914487
151CAMK10.46647881
152NUAK10.45652001
153KIT0.45179894
154TESK10.45121700
155SCYL20.44982290
156EPHB10.44740383
157HIPK20.44632967
158PKN10.43961040
159CAMK2A0.43805331
160LRRK20.43164056
161PRKAA10.41842508
162BCR0.41445946
163PRKAA20.40957854
164PIK3CG0.40789340
165PRKACA0.40376035
166CAMKK20.39542346
167CSNK1A10.39468984
168GRK70.38470471
169PRKCQ0.38266473
170CAMK1G0.37382950

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.33095267
2Phototransduction_Homo sapiens_hsa047442.96321891
3Base excision repair_Homo sapiens_hsa034102.81789557
4Primary immunodeficiency_Homo sapiens_hsa053402.71162744
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.65152470
6Mismatch repair_Homo sapiens_hsa034302.64905815
7Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.58753779
8Oxidative phosphorylation_Homo sapiens_hsa001902.33653581
9Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.30843707
10RNA transport_Homo sapiens_hsa030132.30391846
11Spliceosome_Homo sapiens_hsa030402.23664480
12Cell cycle_Homo sapiens_hsa041102.22489610
13Non-homologous end-joining_Homo sapiens_hsa034502.17325522
14Homologous recombination_Homo sapiens_hsa034402.15894892
15Nicotine addiction_Homo sapiens_hsa050332.13880443
16alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.13509147
17Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.08420023
18One carbon pool by folate_Homo sapiens_hsa006702.06020085
19NF-kappa B signaling pathway_Homo sapiens_hsa040642.05041706
20Butanoate metabolism_Homo sapiens_hsa006502.03723432
21Linoleic acid metabolism_Homo sapiens_hsa005912.02887258
22Fanconi anemia pathway_Homo sapiens_hsa034601.99914754
23Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.96748559
24Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.90480429
25RNA polymerase_Homo sapiens_hsa030201.88232935
26Nitrogen metabolism_Homo sapiens_hsa009101.87479672
27Antigen processing and presentation_Homo sapiens_hsa046121.85843288
28Measles_Homo sapiens_hsa051621.81892393
29Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.81137704
30Nucleotide excision repair_Homo sapiens_hsa034201.78766858
31Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.75742234
32Parkinsons disease_Homo sapiens_hsa050121.68724211
33Herpes simplex infection_Homo sapiens_hsa051681.64881893
34Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.64683608
35Intestinal immune network for IgA production_Homo sapiens_hsa046721.62777303
36Tryptophan metabolism_Homo sapiens_hsa003801.62421707
37p53 signaling pathway_Homo sapiens_hsa041151.60813966
38Pyrimidine metabolism_Homo sapiens_hsa002401.59801966
39Ether lipid metabolism_Homo sapiens_hsa005651.54992929
40Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.53898471
41Vitamin B6 metabolism_Homo sapiens_hsa007501.51957925
42T cell receptor signaling pathway_Homo sapiens_hsa046601.48085161
43Proteasome_Homo sapiens_hsa030501.43660961
44Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.42400758
45Epstein-Barr virus infection_Homo sapiens_hsa051691.37589576
46RNA degradation_Homo sapiens_hsa030181.36639766
47Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.36413067
48Legionellosis_Homo sapiens_hsa051341.33763583
49Morphine addiction_Homo sapiens_hsa050321.33242082
50mRNA surveillance pathway_Homo sapiens_hsa030151.31991406
51Olfactory transduction_Homo sapiens_hsa047401.31197018
52Basal transcription factors_Homo sapiens_hsa030221.31010912
53Graft-versus-host disease_Homo sapiens_hsa053321.30035369
54Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.26839535
55Leishmaniasis_Homo sapiens_hsa051401.26619486
56B cell receptor signaling pathway_Homo sapiens_hsa046621.25596728
57Huntingtons disease_Homo sapiens_hsa050161.23839098
58Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.22596714
59Cardiac muscle contraction_Homo sapiens_hsa042601.20832062
60Hematopoietic cell lineage_Homo sapiens_hsa046401.20699960
61Caffeine metabolism_Homo sapiens_hsa002321.18827017
62RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.16726811
63Viral carcinogenesis_Homo sapiens_hsa052031.13772740
64Primary bile acid biosynthesis_Homo sapiens_hsa001201.12988857
65Alzheimers disease_Homo sapiens_hsa050101.12472462
66Allograft rejection_Homo sapiens_hsa053301.09680806
67Taste transduction_Homo sapiens_hsa047421.09387039
68Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.08913369
69Selenocompound metabolism_Homo sapiens_hsa004501.08739231
70Collecting duct acid secretion_Homo sapiens_hsa049661.06743613
71HTLV-I infection_Homo sapiens_hsa051661.06372179
72Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.04935458
73Insulin secretion_Homo sapiens_hsa049111.03925429
74Chronic myeloid leukemia_Homo sapiens_hsa052201.01809980
75Peroxisome_Homo sapiens_hsa041461.00660064
76GABAergic synapse_Homo sapiens_hsa047271.00203063
77Propanoate metabolism_Homo sapiens_hsa006400.99440445
78Steroid hormone biosynthesis_Homo sapiens_hsa001400.97909529
79Apoptosis_Homo sapiens_hsa042100.96815132
80Jak-STAT signaling pathway_Homo sapiens_hsa046300.95555092
81Ribosome_Homo sapiens_hsa030100.95282428
82Serotonergic synapse_Homo sapiens_hsa047260.94838343
83Acute myeloid leukemia_Homo sapiens_hsa052210.94211337
84Circadian entrainment_Homo sapiens_hsa047130.94106441
85Hepatitis B_Homo sapiens_hsa051610.93466466
86Systemic lupus erythematosus_Homo sapiens_hsa053220.93044818
87Influenza A_Homo sapiens_hsa051640.92733096
88Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.91666041
89Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.89347517
90Osteoclast differentiation_Homo sapiens_hsa043800.88782085
91Toxoplasmosis_Homo sapiens_hsa051450.88340166
92Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.87850619
93Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.87633536
94Transcriptional misregulation in cancer_Homo sapiens_hsa052020.87522267
95NOD-like receptor signaling pathway_Homo sapiens_hsa046210.85862359
96Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.85124547
97Purine metabolism_Homo sapiens_hsa002300.84979180
98Toll-like receptor signaling pathway_Homo sapiens_hsa046200.83618822
99Small cell lung cancer_Homo sapiens_hsa052220.82605471
100Chemical carcinogenesis_Homo sapiens_hsa052040.81986080
101ABC transporters_Homo sapiens_hsa020100.81652371
102Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.74550725
103Drug metabolism - other enzymes_Homo sapiens_hsa009830.72721749
104Ovarian steroidogenesis_Homo sapiens_hsa049130.71084821
105Glutamatergic synapse_Homo sapiens_hsa047240.70924961
106Arachidonic acid metabolism_Homo sapiens_hsa005900.69528764
107Cysteine and methionine metabolism_Homo sapiens_hsa002700.69199320
108Regulation of autophagy_Homo sapiens_hsa041400.69170394
109Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.68173884
110Hepatitis C_Homo sapiens_hsa051600.67450796
111Mineral absorption_Homo sapiens_hsa049780.65926206
112Salivary secretion_Homo sapiens_hsa049700.65808335
113Viral myocarditis_Homo sapiens_hsa054160.65794135
114Autoimmune thyroid disease_Homo sapiens_hsa053200.65430944
115Pentose phosphate pathway_Homo sapiens_hsa000300.65277265
116Glycerolipid metabolism_Homo sapiens_hsa005610.64826894
117Shigellosis_Homo sapiens_hsa051310.64365915
118beta-Alanine metabolism_Homo sapiens_hsa004100.64054135
119Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.63391932
120TNF signaling pathway_Homo sapiens_hsa046680.63190503
121MicroRNAs in cancer_Homo sapiens_hsa052060.62950049
122Prostate cancer_Homo sapiens_hsa052150.62535078
123Retinol metabolism_Homo sapiens_hsa008300.62213311
124Calcium signaling pathway_Homo sapiens_hsa040200.62025399
125Other glycan degradation_Homo sapiens_hsa005110.61121632
126Circadian rhythm_Homo sapiens_hsa047100.59152321
127Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.59132215
128Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.58536004
129Dopaminergic synapse_Homo sapiens_hsa047280.58314759
130FoxO signaling pathway_Homo sapiens_hsa040680.58052118
131Leukocyte transendothelial migration_Homo sapiens_hsa046700.56738672
132Sulfur relay system_Homo sapiens_hsa041220.56446878
133Metabolic pathways_Homo sapiens_hsa011000.56373219
134Dorso-ventral axis formation_Homo sapiens_hsa043200.56051438
135Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.54518253
136Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.54373937
137Pancreatic cancer_Homo sapiens_hsa052120.50919514
138Type I diabetes mellitus_Homo sapiens_hsa049400.49942595
139Tuberculosis_Homo sapiens_hsa051520.49769173
140Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.49245806
141Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.48898200
142Protein export_Homo sapiens_hsa030600.48139918
143Long-term depression_Homo sapiens_hsa047300.46967505
144Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.46833630
145Folate biosynthesis_Homo sapiens_hsa007900.46685313
146Lysine degradation_Homo sapiens_hsa003100.45859326
147Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.44938476
148SNARE interactions in vesicular transport_Homo sapiens_hsa041300.44856302
149Malaria_Homo sapiens_hsa051440.44051957
150Hedgehog signaling pathway_Homo sapiens_hsa043400.43092817
151Colorectal cancer_Homo sapiens_hsa052100.43044913
152Notch signaling pathway_Homo sapiens_hsa043300.42373258
153Maturity onset diabetes of the young_Homo sapiens_hsa049500.41302770
154Chemokine signaling pathway_Homo sapiens_hsa040620.41072855
155Sulfur metabolism_Homo sapiens_hsa009200.38947059
156Staphylococcus aureus infection_Homo sapiens_hsa051500.37665519
157Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.37308683
158Fatty acid elongation_Homo sapiens_hsa000620.36790865
159N-Glycan biosynthesis_Homo sapiens_hsa005100.35887986
160Thyroid cancer_Homo sapiens_hsa052160.35209798
161TGF-beta signaling pathway_Homo sapiens_hsa043500.34923047
162Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.34906337
163Steroid biosynthesis_Homo sapiens_hsa001000.34859883
164Asthma_Homo sapiens_hsa053100.33468099
165Vascular smooth muscle contraction_Homo sapiens_hsa042700.32725863
166Pertussis_Homo sapiens_hsa051330.32025025
167Vitamin digestion and absorption_Homo sapiens_hsa049770.32010995
168Rheumatoid arthritis_Homo sapiens_hsa053230.31540864
169Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.31003209
170Fatty acid degradation_Homo sapiens_hsa000710.30699613
171Pentose and glucuronate interconversions_Homo sapiens_hsa000400.30352118
172Insulin resistance_Homo sapiens_hsa049310.30143071
173cAMP signaling pathway_Homo sapiens_hsa040240.30045548
174Cocaine addiction_Homo sapiens_hsa050300.29739050

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