PKNOX2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Homeodomain proteins are sequence-specific transcription factors that share a highly conserved DNA-binding domain and play fundamental roles in cell proliferation, differentiation, and death. PKNOX2 belongs to the TALE (3-amino acid loop extension) class of homeodomain proteins characterized by a 3-amino acid extension between alpha helices 1 and 2 within the homeodomain (Imoto et al., 2001 [PubMed 11549286]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.19936308
2vocalization behavior (GO:0071625)5.15394551
3synaptic vesicle docking involved in exocytosis (GO:0016081)5.05095893
4synaptic vesicle maturation (GO:0016188)4.95853653
5synaptic vesicle exocytosis (GO:0016079)4.86105817
6regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.85142323
7glutamate secretion (GO:0014047)4.84329086
8positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.74301576
9positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.65031358
10protein localization to synapse (GO:0035418)4.55841257
11neuron cell-cell adhesion (GO:0007158)4.49834519
12locomotory exploration behavior (GO:0035641)4.45907608
13regulation of glutamate receptor signaling pathway (GO:1900449)4.37147030
14regulation of synaptic vesicle exocytosis (GO:2000300)4.36812469
15neuronal action potential propagation (GO:0019227)4.19505153
16layer formation in cerebral cortex (GO:0021819)4.06792620
17behavioral response to nicotine (GO:0035095)4.06440479
18regulation of synapse structural plasticity (GO:0051823)4.06284314
19regulation of synaptic vesicle transport (GO:1902803)3.90253752
20neurotransmitter-gated ion channel clustering (GO:0072578)3.79323100
21neurotransmitter secretion (GO:0007269)3.77233254
22membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.77137179
23ionotropic glutamate receptor signaling pathway (GO:0035235)3.73549137
24cell migration in hindbrain (GO:0021535)3.70577002
25regulation of neuronal synaptic plasticity (GO:0048168)3.70386716
26exploration behavior (GO:0035640)3.67927715
27regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.65865852
28synaptic transmission, glutamatergic (GO:0035249)3.64914872
29positive regulation of synapse maturation (GO:0090129)3.64779941
30regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.63042512
31dendritic spine morphogenesis (GO:0060997)3.61535212
32neuron recognition (GO:0008038)3.56908077
33regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.56525119
34regulation of long-term neuronal synaptic plasticity (GO:0048169)3.52635012
35axonal fasciculation (GO:0007413)3.45585143
36neuron-neuron synaptic transmission (GO:0007270)3.44720578
37glutamate receptor signaling pathway (GO:0007215)3.41388123
38postsynaptic membrane organization (GO:0001941)3.41185092
39cerebellar Purkinje cell differentiation (GO:0021702)3.37355710
40proline transport (GO:0015824)3.35658505
41membrane depolarization during action potential (GO:0086010)3.30992617
42auditory behavior (GO:0031223)3.29114374
43establishment of nucleus localization (GO:0040023)3.28213412
44synaptic vesicle endocytosis (GO:0048488)3.24953516
45gamma-aminobutyric acid transport (GO:0015812)3.24928966
46central nervous system myelination (GO:0022010)3.23572221
47axon ensheathment in central nervous system (GO:0032291)3.23572221
48regulation of excitatory postsynaptic membrane potential (GO:0060079)3.20009332
49innervation (GO:0060384)3.14068913
50response to auditory stimulus (GO:0010996)3.12215470
51cell proliferation in forebrain (GO:0021846)3.11233782
52regulation of postsynaptic membrane potential (GO:0060078)3.09129139
53negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.08708583
54activation of protein kinase A activity (GO:0034199)3.07421236
55positive regulation of synaptic transmission, GABAergic (GO:0032230)3.05746742
56regulation of synaptic plasticity (GO:0048167)3.04615063
57long-term memory (GO:0007616)3.04209855
58dendrite morphogenesis (GO:0048813)3.03255242
59negative regulation of synaptic transmission, GABAergic (GO:0032229)3.01446529
60regulation of dendritic spine morphogenesis (GO:0061001)3.00494785
61presynaptic membrane assembly (GO:0097105)3.00311186
62regulation of synaptic transmission, glutamatergic (GO:0051966)2.99582758
63positive regulation of membrane potential (GO:0045838)2.97944225
64regulation of neurotransmitter secretion (GO:0046928)2.97904341
65positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.96570297
66cell communication by electrical coupling (GO:0010644)2.95401438
67pyrimidine nucleobase catabolic process (GO:0006208)2.95255898
68membrane depolarization (GO:0051899)2.93503663
69neuronal ion channel clustering (GO:0045161)2.90387140
70neurotransmitter transport (GO:0006836)2.89689551
71long-term synaptic potentiation (GO:0060291)2.89409707
72neuromuscular process controlling balance (GO:0050885)2.88997417
73calcium ion-dependent exocytosis (GO:0017156)2.88643302
74gamma-aminobutyric acid signaling pathway (GO:0007214)2.88552923
75central nervous system projection neuron axonogenesis (GO:0021952)2.88241574
76regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.87631717
77regulation of synapse maturation (GO:0090128)2.87048805
78positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.86169483
79transmission of nerve impulse (GO:0019226)2.85381677
80negative regulation of microtubule polymerization (GO:0031115)2.84533110
81synapse assembly (GO:0007416)2.84130378
82cellular potassium ion homeostasis (GO:0030007)2.81639180
83presynaptic membrane organization (GO:0097090)2.80602443
84positive regulation of dendritic spine development (GO:0060999)2.78802785
85positive regulation of synapse assembly (GO:0051965)2.78575311
86positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.77601997
87neuromuscular synaptic transmission (GO:0007274)2.76237720
88positive regulation of neurotransmitter secretion (GO:0001956)2.76072515
89synapse organization (GO:0050808)2.75934081
90neuronal stem cell maintenance (GO:0097150)2.75687175
91regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.74741148
92membrane hyperpolarization (GO:0060081)2.73617539
93axon extension (GO:0048675)2.72272649
94G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.72109560
95neuromuscular process (GO:0050905)2.71972595
96mechanosensory behavior (GO:0007638)2.71757180
97cerebellar granule cell differentiation (GO:0021707)2.71757087
98positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.70841130
99negative regulation of dendrite development (GO:2000171)2.70738292
100regulation of respiratory system process (GO:0044065)2.69975700
101behavioral fear response (GO:0001662)2.69892028
102behavioral defense response (GO:0002209)2.69892028
103spinal cord development (GO:0021510)2.69815932
104regulation of neurotransmitter levels (GO:0001505)2.68956405
105neuronal action potential (GO:0019228)2.68666678
106regulation of neurotransmitter transport (GO:0051588)2.68410131
107positive regulation of neurotransmitter transport (GO:0051590)2.66916511
108urinary tract smooth muscle contraction (GO:0014848)2.66443881
109synaptic transmission (GO:0007268)2.66358500
110prepulse inhibition (GO:0060134)2.65882705
111cell differentiation in hindbrain (GO:0021533)2.65304929
112positive regulation of gastrulation (GO:2000543)2.61595282
113cochlea development (GO:0090102)2.60607855
114serotonin metabolic process (GO:0042428)2.51940783
115positive regulation of dendritic spine morphogenesis (GO:0061003)2.50757523
116nonmotile primary cilium assembly (GO:0035058)2.49568678
117appendage development (GO:0048736)2.47833892
118limb development (GO:0060173)2.47833892
119midbrain development (GO:0030901)2.46560358
120retinal ganglion cell axon guidance (GO:0031290)2.45956529
121primary amino compound metabolic process (GO:1901160)2.43882308
122regulation of synapse assembly (GO:0051963)2.43879670
123hindbrain development (GO:0030902)2.40960073
124somite development (GO:0061053)2.40484328
125otic vesicle formation (GO:0030916)2.39867673
126adult walking behavior (GO:0007628)2.39666143
127limb bud formation (GO:0060174)2.39259317
128phosphorelay signal transduction system (GO:0000160)2.38400347
129negative regulation of axon guidance (GO:1902668)2.37258860
130startle response (GO:0001964)2.36464147
131regulation of respiratory gaseous exchange (GO:0043576)2.34892631
132chemosensory behavior (GO:0007635)2.33910192
133negative regulation of astrocyte differentiation (GO:0048712)2.33389683
134dendritic spine organization (GO:0097061)2.32817631

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* EZH2_22144423_ChIP-Seq_EOC_Human6.31204586
2GBX2_23144817_ChIP-Seq_PC3_Human3.29916159
3* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.00067707
4* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.90183745
5* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.88104693
6* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.75822368
7* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.75822368
8* EZH2_27304074_Chip-Seq_ESCs_Mouse2.67277220
9* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.56462227
10SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.51880987
11EED_16625203_ChIP-ChIP_MESCs_Mouse2.49335174
12* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.47946895
13SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.43922640
14REST_21632747_ChIP-Seq_MESCs_Mouse2.42443562
15* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.35165468
16* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.32641821
17* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.29740488
18* RNF2_27304074_Chip-Seq_ESCs_Mouse2.28792060
19* EZH2_27294783_Chip-Seq_ESCs_Mouse2.25240733
20DROSHA_22980978_ChIP-Seq_HELA_Human2.23670886
21* RARB_27405468_Chip-Seq_BRAIN_Mouse2.17805222
22GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.15618127
23ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.11169804
24NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.08832494
25REST_18959480_ChIP-ChIP_MESCs_Mouse2.00229669
26CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.97159319
27HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.88340497
28EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.79523264
29* CBX2_27304074_Chip-Seq_ESCs_Mouse1.72964230
30CTBP2_25329375_ChIP-Seq_LNCAP_Human1.72781516
31TAF15_26573619_Chip-Seq_HEK293_Human1.71356700
32MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.67103971
33PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.66643634
34CTBP1_25329375_ChIP-Seq_LNCAP_Human1.59268987
35CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.59073890
36RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.57920246
37TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.55559417
38IKZF1_21737484_ChIP-ChIP_HCT116_Human1.55256225
39* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.51286003
40BMI1_23680149_ChIP-Seq_NPCS_Mouse1.49956477
41ZNF274_21170338_ChIP-Seq_K562_Hela1.47090104
42SMAD4_21799915_ChIP-Seq_A2780_Human1.47042865
43* RING1B_27294783_Chip-Seq_ESCs_Mouse1.46041310
44ERG_21242973_ChIP-ChIP_JURKAT_Human1.45724290
45AR_21572438_ChIP-Seq_LNCaP_Human1.43395904
46PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.42206841
47RNF2_27304074_Chip-Seq_NSC_Mouse1.38307212
48SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.35945100
49* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.31952014
50RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.26602034
51* RING1B_27294783_Chip-Seq_NPCs_Mouse1.26448396
52SOX2_21211035_ChIP-Seq_LN229_Gbm1.25825903
53P300_19829295_ChIP-Seq_ESCs_Human1.24126199
54RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.23903502
55ZFP281_18757296_ChIP-ChIP_E14_Mouse1.23666787
56* TP63_19390658_ChIP-ChIP_HaCaT_Human1.22220090
57TOP2B_26459242_ChIP-Seq_MCF-7_Human1.22036120
58* AR_19668381_ChIP-Seq_PC3_Human1.21701351
59SMAD3_21741376_ChIP-Seq_EPCs_Human1.21273673
60AR_25329375_ChIP-Seq_VCAP_Human1.18440870
61EWS_26573619_Chip-Seq_HEK293_Human1.18205724
62ARNT_22903824_ChIP-Seq_MCF-7_Human1.17980049
63AHR_22903824_ChIP-Seq_MCF-7_Human1.15313561
64* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.14626421
65NR3C1_21868756_ChIP-Seq_MCF10A_Human1.13724510
66MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.13574054
67PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.10827766
68YAP1_20516196_ChIP-Seq_MESCs_Mouse1.10526106
69NR3C1_23031785_ChIP-Seq_PC12_Mouse1.10504840
70POU3F2_20337985_ChIP-ChIP_501MEL_Human1.10338016
71* CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.09986598
72PIAS1_25552417_ChIP-Seq_VCAP_Human1.09797454
73TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.08498885
74MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.07955764
75* TP53_20018659_ChIP-ChIP_R1E_Mouse1.07427175
76STAT3_23295773_ChIP-Seq_U87_Human1.07383730
77OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.07134721
78* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.06892643
79GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06349016
80KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.05337261
81GATA1_26923725_Chip-Seq_HPCs_Mouse1.05014101
82LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04708498
83POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.03899780
84TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03899780
85RBPJ_22232070_ChIP-Seq_NCS_Mouse1.03847579
86POU5F1_16153702_ChIP-ChIP_HESCs_Human1.03072675
87SMAD3_21741376_ChIP-Seq_ESCs_Human1.02576603
88IGF1R_20145208_ChIP-Seq_DFB_Human0.99949859
89DNAJC2_21179169_ChIP-ChIP_NT2_Human0.99760786
90SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.98969385
91ZNF217_24962896_ChIP-Seq_MCF-7_Human0.98602251
92SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.97828393
93TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97701062
94RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.96897084
95IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.96564538
96CBP_20019798_ChIP-Seq_JUKART_Human0.96564538
97P53_22127205_ChIP-Seq_FIBROBLAST_Human0.96519123
98* TCF4_23295773_ChIP-Seq_U87_Human0.96206272
99* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.96016258
100* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.95681526
101VDR_22108803_ChIP-Seq_LS180_Human0.95461907
102MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.94147647
103TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.93507663
104KDM2B_26808549_Chip-Seq_K562_Human0.93196949
105CDX2_19796622_ChIP-Seq_MESCs_Mouse0.92132864
106AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.92063602
107* SMAD4_21741376_ChIP-Seq_HESCs_Human0.91474695
108EP300_21415370_ChIP-Seq_HL-1_Mouse0.91301283
109CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91106954
110FUS_26573619_Chip-Seq_HEK293_Human0.90664947
111RUNX2_22187159_ChIP-Seq_PCA_Human0.89944373
112UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.89632882
113SOX9_26525672_Chip-Seq_HEART_Mouse0.89421754
114SMAD_19615063_ChIP-ChIP_OVARY_Human0.88901651
115EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.88641866
116* TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.88423708
117* OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.87599172

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.46661628
2MP0003880_abnormal_central_pattern3.97002015
3MP0004270_analgesia3.59751603
4MP0003635_abnormal_synaptic_transmissio3.54143088
5MP0003136_yellow_coat_color2.95395757
6MP0002063_abnormal_learning/memory/cond2.94027647
7MP0000566_synostosis2.91363057
8MP0001968_abnormal_touch/_nociception2.80662599
9MP0009745_abnormal_behavioral_response2.69783875
10MP0002064_seizures2.54797569
11MP0009046_muscle_twitch2.52940068
12MP0002734_abnormal_mechanical_nocicepti2.52362414
13MP0006292_abnormal_olfactory_placode2.40795127
14MP0002572_abnormal_emotion/affect_behav2.35598278
15MP0002735_abnormal_chemical_nociception2.32599998
16MP0005171_absent_coat_pigmentation2.29482654
17MP0000751_myopathy2.27369012
18MP0002736_abnormal_nociception_after2.26744052
19MP0005423_abnormal_somatic_nervous2.20522203
20MP0001486_abnormal_startle_reflex2.14190371
21MP0002272_abnormal_nervous_system2.09547562
22MP0000778_abnormal_nervous_system2.05749578
23MP0004145_abnormal_muscle_electrophysio1.96309401
24MP0004858_abnormal_nervous_system1.89865381
25MP0006276_abnormal_autonomic_nervous1.87960496
26MP0002184_abnormal_innervation1.87642672
27MP0001440_abnormal_grooming_behavior1.76223462
28MP0002067_abnormal_sensory_capabilities1.75586077
29MP0003122_maternal_imprinting1.74388639
30MP0002733_abnormal_thermal_nociception1.73486381
31MP0004811_abnormal_neuron_physiology1.69403471
32MP0002557_abnormal_social/conspecific_i1.67910705
33MP0010030_abnormal_orbit_morphology1.67783949
34MP0001984_abnormal_olfaction1.65692698
35MP0002938_white_spotting1.65688331
36MP0001970_abnormal_pain_threshold1.65478840
37MP0001485_abnormal_pinna_reflex1.64568964
38MP0001501_abnormal_sleep_pattern1.63080964
39MP0004233_abnormal_muscle_weight1.57976698
40MP0009780_abnormal_chondrocyte_physiolo1.54038841
41MP0000955_abnormal_spinal_cord1.53799892
42MP0002653_abnormal_ependyma_morphology1.52826160
43MP0008569_lethality_at_weaning1.52559157
44MP0002822_catalepsy1.52106389
45MP0002837_dystrophic_cardiac_calcinosis1.44676786
46MP0001529_abnormal_vocalization1.43254025
47MP0000569_abnormal_digit_pigmentation1.43083836
48MP0005646_abnormal_pituitary_gland1.41020558
49MP0002882_abnormal_neuron_morphology1.39634566
50MP0000049_abnormal_middle_ear1.39288100
51MP0005386_behavior/neurological_phenoty1.36169254
52MP0004924_abnormal_behavior1.36169254
53MP0002249_abnormal_larynx_morphology1.32942620
54MP0003646_muscle_fatigue1.31850804
55MP0003787_abnormal_imprinting1.30822317
56MP0005623_abnormal_meninges_morphology1.28346208
57MP0003879_abnormal_hair_cell1.26996491
58MP0002066_abnormal_motor_capabilities/c1.26263975
59MP0001346_abnormal_lacrimal_gland1.22442332
60MP0002152_abnormal_brain_morphology1.21078103
61MP0005410_abnormal_fertilization1.20666354
62MP0002909_abnormal_adrenal_gland1.19840566
63MP0003890_abnormal_embryonic-extraembry1.16922718
64MP0000749_muscle_degeneration1.13732943
65MP0005551_abnormal_eye_electrophysiolog1.13584696
66MP0003329_amyloid_beta_deposits1.12311753
67MP0003283_abnormal_digestive_organ1.11491335
68MP0000534_abnormal_ureter_morphology1.10931503
69MP0004215_abnormal_myocardial_fiber1.09890128
70MP0001293_anophthalmia1.08978918
71MP0002638_abnormal_pupillary_reflex1.08266353
72MP0003937_abnormal_limbs/digits/tail_de1.08181876
73MP0008961_abnormal_basal_metabolism1.06067062
74MP0004885_abnormal_endolymph1.04284119
75MP0004133_heterotaxia1.03870516
76MP0003119_abnormal_digestive_system1.03190855
77MP0009379_abnormal_foot_pigmentation1.03041066
78MP0003137_abnormal_impulse_conducting1.02482220
79MP0005645_abnormal_hypothalamus_physiol1.01056527
80MP0001502_abnormal_circadian_rhythm1.00405607
81MP0005499_abnormal_olfactory_system0.97233525
82MP0005394_taste/olfaction_phenotype0.97233525
83MP0003861_abnormal_nervous_system0.96143588
84MP0000372_irregular_coat_pigmentation0.95669687
85MP0004085_abnormal_heartbeat0.95479754
86MP0000631_abnormal_neuroendocrine_gland0.92775279
87MP0008877_abnormal_DNA_methylation0.92738233
88MP0005377_hearing/vestibular/ear_phenot0.91825988
89MP0003878_abnormal_ear_physiology0.91825988
90MP0009053_abnormal_anal_canal0.90699340
91MP0002752_abnormal_somatic_nervous0.87991108
92MP0005620_abnormal_muscle_contractility0.86758393
93MP0004036_abnormal_muscle_relaxation0.85414821
94MP0002234_abnormal_pharynx_morphology0.82634174
95MP0003121_genomic_imprinting0.82423622
96MP0003633_abnormal_nervous_system0.81706344
97MP0000537_abnormal_urethra_morphology0.81512045
98MP0001299_abnormal_eye_distance/0.80700428
99MP0010386_abnormal_urinary_bladder0.80691138
100MP0002116_abnormal_craniofacial_bone0.79675876
101MP0002108_abnormal_muscle_morphology0.79423855
102MP0003755_abnormal_palate_morphology0.79205274
103MP0003385_abnormal_body_wall0.78996202
104MP0002069_abnormal_eating/drinking_beha0.77691946
105MP0004142_abnormal_muscle_tone0.77388493
106MP0005369_muscle_phenotype0.76826702
107MP0002106_abnormal_muscle_physiology0.76369397
108MP0001905_abnormal_dopamine_level0.76189104
109MP0000759_abnormal_skeletal_muscle0.75039096
110MP0004742_abnormal_vestibular_system0.74970384
111MP0001963_abnormal_hearing_physiology0.74825056
112MP0003631_nervous_system_phenotype0.74821299
113MP0004484_altered_response_of0.74630690
114MP0002081_perinatal_lethality0.74586692
115MP0000747_muscle_weakness0.73703172
116MP0003632_abnormal_nervous_system0.72979260
117MP0001286_abnormal_eye_development0.72791028
118MP0003942_abnormal_urinary_system0.71721676
119MP0001986_abnormal_taste_sensitivity0.71707441
120MP0005253_abnormal_eye_physiology0.71553917
121MP0001177_atelectasis0.70701948
122MP0003698_abnormal_male_reproductive0.70388176
123MP0002102_abnormal_ear_morphology0.68699027
124MP0005187_abnormal_penis_morphology0.67015938
125MP0001943_abnormal_respiration0.66673062
126MP0008789_abnormal_olfactory_epithelium0.66160644
127MP0000026_abnormal_inner_ear0.65613534
128MP0009250_abnormal_appendicular_skeleto0.65298929
129MP0002269_muscular_atrophy0.64829947
130MP0003938_abnormal_ear_development0.64365716

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.13837744
2Myokymia (HP:0002411)5.23831877
3Focal seizures (HP:0007359)4.63913128
4Epileptic encephalopathy (HP:0200134)4.28339970
5Atonic seizures (HP:0010819)4.07345276
6Febrile seizures (HP:0002373)3.85529208
7Visual hallucinations (HP:0002367)3.47072056
8Absence seizures (HP:0002121)3.16933893
9Progressive cerebellar ataxia (HP:0002073)3.16195350
10Action tremor (HP:0002345)3.02154130
11Broad-based gait (HP:0002136)2.99757126
12Generalized tonic-clonic seizures (HP:0002069)2.97781125
13Dialeptic seizures (HP:0011146)2.92439029
14Hyperventilation (HP:0002883)2.88442256
15Exercise-induced myalgia (HP:0003738)2.86573897
16Impaired vibration sensation in the lower limbs (HP:0002166)2.86477591
17Ankle clonus (HP:0011448)2.84486257
18Amblyopia (HP:0000646)2.67681154
19Shoulder girdle muscle weakness (HP:0003547)2.59725737
20Urinary bladder sphincter dysfunction (HP:0002839)2.58606449
21Abnormality of the lower motor neuron (HP:0002366)2.57864384
22Bilateral microphthalmos (HP:0007633)2.51980497
23Poor eye contact (HP:0000817)2.50848659
24Nephronophthisis (HP:0000090)2.49371286
25Gaze-evoked nystagmus (HP:0000640)2.40104640
26Impaired social interactions (HP:0000735)2.36434652
27Abnormal social behavior (HP:0012433)2.36434652
28Dysdiadochokinesis (HP:0002075)2.36253480
29Fetal akinesia sequence (HP:0001989)2.36105527
30Short 4th metacarpal (HP:0010044)2.33935294
31Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.33935294
32Urinary urgency (HP:0000012)2.33411950
33Depression (HP:0000716)2.31209112
34Excessive salivation (HP:0003781)2.29414513
35Drooling (HP:0002307)2.29414513
36Insidious onset (HP:0003587)2.24215004
37Termporal pattern (HP:0011008)2.24215004
38Pancreatic fibrosis (HP:0100732)2.24089943
39Abnormal eating behavior (HP:0100738)2.23987997
40Hemiparesis (HP:0001269)2.23510209
41Hypoplasia of the fovea (HP:0007750)2.22342103
42Aplasia/Hypoplasia of the fovea (HP:0008060)2.22342103
43Dysmetric saccades (HP:0000641)2.22234622
44Dynein arm defect of respiratory motile cilia (HP:0012255)2.20920708
45Absent/shortened dynein arms (HP:0200106)2.20920708
46Genetic anticipation (HP:0003743)2.20324256
47Supranuclear gaze palsy (HP:0000605)2.19339559
48Hypoplastic ischia (HP:0003175)2.18940185
49Muscle hypertrophy of the lower extremities (HP:0008968)2.18451980
50Abnormality of the 4th metacarpal (HP:0010012)2.18434423
51Truncal ataxia (HP:0002078)2.16325139
52Abnormality of the calf musculature (HP:0001430)2.16042731
53Rib fusion (HP:0000902)2.13882245
54Concave nail (HP:0001598)2.13477460
55Septo-optic dysplasia (HP:0100842)2.12450914
56Calf muscle hypertrophy (HP:0008981)2.11120227
57True hermaphroditism (HP:0010459)2.08492763
58Absent speech (HP:0001344)2.08304824
59Abnormality of the parietal bone (HP:0002696)2.06349905
60Pancreatic cysts (HP:0001737)2.04482815
61Difficulty running (HP:0009046)2.04134764
62Abnormality of the ischium (HP:0003174)2.03995018
63Limb dystonia (HP:0002451)2.03946728
64Neoplasm of the heart (HP:0100544)2.03746680
65Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.02696126
66Partial agenesis of the corpus callosum (HP:0001338)2.01735096
67Narrow nasal bridge (HP:0000446)2.01595578
68Postural instability (HP:0002172)2.00844578
69Gait imbalance (HP:0002141)1.99198191
70Myotonia (HP:0002486)1.98915309
71Abnormality of binocular vision (HP:0011514)1.97783418
72Diplopia (HP:0000651)1.97783418
73Impaired vibratory sensation (HP:0002495)1.96343968
74Abnormality of midbrain morphology (HP:0002418)1.96143265
75Molar tooth sign on MRI (HP:0002419)1.96143265
76Tracheomalacia (HP:0002779)1.96098855
77Abnormality of the renal medulla (HP:0100957)1.95882483
78Epileptiform EEG discharges (HP:0011182)1.95643997
79Esophageal atresia (HP:0002032)1.95424685
80Aplasia/Hypoplasia of the brainstem (HP:0007362)1.94931717
81Hypoplasia of the brainstem (HP:0002365)1.94931717
82Polyphagia (HP:0002591)1.93364192
83Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.93249435
84Fibular hypoplasia (HP:0003038)1.93136745
85Abnormality of the fovea (HP:0000493)1.92907581
86Sleep apnea (HP:0010535)1.92605083
87Impaired smooth pursuit (HP:0007772)1.92501052
88Torticollis (HP:0000473)1.91184856
89Dysmetria (HP:0001310)1.90623834
90Hypoventilation (HP:0002791)1.90307572
91Chronic hepatic failure (HP:0100626)1.89989233
92Increased variability in muscle fiber diameter (HP:0003557)1.89184601
93Failure to thrive in infancy (HP:0001531)1.88194258
94Abnormality of the musculature of the pelvis (HP:0001469)1.87984530
95Abnormality of the hip-girdle musculature (HP:0001445)1.87984530
96Abnormality of the diencephalon (HP:0010662)1.86765804
97Pelvic girdle muscle weakness (HP:0003749)1.85704824
98EEG with generalized epileptiform discharges (HP:0011198)1.85363414
99Mutism (HP:0002300)1.84824060
100Lower limb muscle weakness (HP:0007340)1.83111405
101Sudden death (HP:0001699)1.82703054
102Annular pancreas (HP:0001734)1.80861035
103Specific learning disability (HP:0001328)1.80749681
104Patellar aplasia (HP:0006443)1.80622789
105Optic nerve hypoplasia (HP:0000609)1.80346659
106Midline defect of the nose (HP:0004122)1.80015987
107Abnormality of the aortic arch (HP:0012303)1.79929548
108Absent septum pellucidum (HP:0001331)1.78117591
109Bundle branch block (HP:0011710)1.78062155
110Megalencephaly (HP:0001355)1.76466809
111Hypsarrhythmia (HP:0002521)1.75830275
112Hyperthyroidism (HP:0000836)1.75661615
113Exercise-induced muscle cramps (HP:0003710)1.75628608
114Pointed chin (HP:0000307)1.75581810
115Anosmia (HP:0000458)1.75546139
116Incomplete penetrance (HP:0003829)1.75528256
117Lissencephaly (HP:0001339)1.75508798
118Abnormal number of incisors (HP:0011064)1.75367130
119Spastic gait (HP:0002064)1.75264378
120Muscle fiber inclusion bodies (HP:0100299)1.75192559
121Medial flaring of the eyebrow (HP:0010747)1.74646573
122Shawl scrotum (HP:0000049)1.74633863
123Anxiety (HP:0000739)1.74048737
124Pheochromocytoma (HP:0002666)1.74011133
125Bony spicule pigmentary retinopathy (HP:0007737)1.73436467
126Focal dystonia (HP:0004373)1.72439171
127Amyotrophic lateral sclerosis (HP:0007354)1.72410578
128Stereotypic behavior (HP:0000733)1.72069189
129Oligodactyly (hands) (HP:0001180)1.71475759
130Abnormality of ocular smooth pursuit (HP:0000617)1.70855439
131Inability to walk (HP:0002540)1.70583768
132Cystic liver disease (HP:0006706)1.70490474
133Hemiplegia (HP:0002301)1.69741228
134Type 1 muscle fiber predominance (HP:0003803)1.67948384
135Mixed hearing impairment (HP:0000410)1.67917150
136Cutaneous finger syndactyly (HP:0010554)1.67808540
137Abnormality of the labia minora (HP:0012880)1.67004817
138Bradykinesia (HP:0002067)1.66698622
139Progressive inability to walk (HP:0002505)1.66673328
140Vaginal atresia (HP:0000148)1.66134421
141Genital tract atresia (HP:0001827)1.65978141
142Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.65782211
143Ventricular fibrillation (HP:0001663)1.65162149
144Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.64866177
145Poor coordination (HP:0002370)1.64469955
146Lower limb amyotrophy (HP:0007210)1.64343539
147Protruding tongue (HP:0010808)1.64331836
148Anencephaly (HP:0002323)1.63832055
149Abnormality of pain sensation (HP:0010832)1.63722115
150Impaired pain sensation (HP:0007328)1.63722115
151Exotropia (HP:0000577)1.63709894
152Abnormal ciliary motility (HP:0012262)1.62779181
153Anophthalmia (HP:0000528)1.62096094
154Aplasia/Hypoplasia of the patella (HP:0006498)1.61715869
155Sclerocornea (HP:0000647)1.60880704
156Congenital stationary night blindness (HP:0007642)1.60867147
157Morphological abnormality of the inner ear (HP:0011390)1.59504083
158Autism (HP:0000717)1.59426549
159Preaxial foot polydactyly (HP:0001841)1.59171423
160Ulnar claw (HP:0001178)1.57886063
161Abnormal respiratory epithelium morphology (HP:0012253)1.57466871
162Abnormal respiratory motile cilium morphology (HP:0005938)1.57466871
163Trigonocephaly (HP:0000243)1.56367882
164Gastrointestinal atresia (HP:0002589)1.55762745
165Truncal obesity (HP:0001956)1.55672713
166Congenital primary aphakia (HP:0007707)1.53689408
167Abnormality of the phalanges of the 2nd finger (HP:0009541)1.52491091

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK33.56681155
2MARK13.40846344
3EPHA43.15038128
4MAP3K93.05191941
5MAP3K42.93306960
6MINK12.60928511
7DAPK22.51387594
8CASK2.41341668
9CDK122.38489225
10PRKD32.34974904
11SIK32.32109232
12NTRK22.31078511
13MAP2K72.29004567
14KSR12.18557839
15PAK62.08731452
16PHKG21.98046222
17PHKG11.98046222
18MAP2K41.73011455
19KSR21.71675180
20INSRR1.64802957
21MAPK131.63391775
22PLK21.63201481
23MAPK151.57908641
24LATS21.56725235
25TYRO31.54905248
26MKNK21.52529114
27CDK191.50919730
28CAMKK11.49142942
29DAPK11.46141909
30UHMK11.32935425
31CDK51.32297590
32STK381.31299228
33SIK21.29364572
34BMPR1B1.26754776
35NTRK11.23850124
36PDK41.22621495
37PDK31.22621495
38GRK51.20487963
39PRPF4B1.20231220
40FRK1.18903090
41BCR1.16437160
42MAP3K121.16233907
43ICK1.15844560
44CCNB11.15206959
45NEK11.12873541
46CDK181.10708587
47PKN11.10072126
48PRKCG1.08910178
49WNK31.05709467
50TAF11.05188234
51CAMK1D1.02811115
52CDK150.99758480
53PNCK0.98150606
54CDK140.96209585
55EPHB20.94895430
56LMTK20.94703418
57ERBB30.93317827
58PTK2B0.90887467
59WNK40.88761399
60MKNK10.87118221
61CDK11A0.85426201
62CDC70.82128712
63WNK10.81711117
64PAK30.80804587
65MAPKAPK50.80545777
66CDK30.80441195
67CAMK2A0.77883290
68SGK2230.77768076
69SGK4940.77768076
70DMPK0.76929048
71FGFR20.76350090
72BRD40.76044047
73AKT30.75318639
74STK38L0.74178661
75ADRBK20.73340276
76OBSCN0.73126963
77FER0.72122708
78PDGFRA0.69663901
79RET0.68423967
80SGK20.68066426
81ARAF0.68013136
82DDR20.66328211
83TNIK0.65438341
84STK390.64530708
85WEE10.64517494
86LIMK10.64410511
87CAMK1G0.63303156
88ERBB20.61810826
89CAMKK20.61649615
90STK110.61069867
91ZAK0.60442455
92PRKG10.60129280
93MUSK0.58974345
94OXSR10.58623476
95MARK20.56423401
96NME10.55636462
97NUAK10.55391350
98PINK10.55109462
99CSNK1E0.54320507
100LATS10.54044621
101TAOK10.54009123
102DYRK1B0.53660047
103VRK10.52923412
104TTN0.51865189
105CAMK10.51843655
106PLK40.51775354
107SGK10.51661746
108RIPK40.51551048
109GRK10.51541231
110TLK10.51194583
111DYRK1A0.50796948
112CSNK1G20.50636740
113TESK10.50543215
114SGK30.50406785
115DYRK30.49847501
116MAP3K20.49771504
117PRKCH0.49699439
118CDC42BPA0.49577157
119GSK3B0.48894183
120PRKAA10.48883895
121PDK20.48493527
122CHEK20.46853148
123DYRK20.46339133
124CAMK2B0.46259456
125RPS6KA30.44971791
126PRKCZ0.44847481
127RPS6KA60.44466131
128PRKCE0.44207722
129ROCK10.42899008
130CAMK40.42423285
131ROCK20.41325651
132MAP2K10.40854527
133IRAK20.40357573
134PDPK10.38086615
135RPS6KA20.37359578
136FGFR10.36421505
137RAF10.36194611
138MAPK100.34107524

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.40373210
2Synaptic vesicle cycle_Homo sapiens_hsa047213.23611742
3Olfactory transduction_Homo sapiens_hsa047402.67653527
4Circadian entrainment_Homo sapiens_hsa047132.47169554
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.37189759
6GABAergic synapse_Homo sapiens_hsa047272.37028634
7Long-term potentiation_Homo sapiens_hsa047202.30192855
8Morphine addiction_Homo sapiens_hsa050322.23612779
9Glutamatergic synapse_Homo sapiens_hsa047242.22586282
10Amphetamine addiction_Homo sapiens_hsa050312.21606100
11Dopaminergic synapse_Homo sapiens_hsa047282.06796793
12Insulin secretion_Homo sapiens_hsa049111.92054352
13Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.85444681
14Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.81938879
15Salivary secretion_Homo sapiens_hsa049701.81668792
16Cholinergic synapse_Homo sapiens_hsa047251.77221226
17Oxytocin signaling pathway_Homo sapiens_hsa049211.72418735
18Aldosterone synthesis and secretion_Homo sapiens_hsa049251.68330180
19Gastric acid secretion_Homo sapiens_hsa049711.66079144
20Calcium signaling pathway_Homo sapiens_hsa040201.57649019
21Taste transduction_Homo sapiens_hsa047421.56149872
22Renin secretion_Homo sapiens_hsa049241.54141158
23Axon guidance_Homo sapiens_hsa043601.53802293
24Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.46472785
25Collecting duct acid secretion_Homo sapiens_hsa049661.46309515
26Long-term depression_Homo sapiens_hsa047301.42938173
27Serotonergic synapse_Homo sapiens_hsa047261.42768642
28Cocaine addiction_Homo sapiens_hsa050301.41281656
29Gap junction_Homo sapiens_hsa045401.41231219
30GnRH signaling pathway_Homo sapiens_hsa049121.40610440
31Cardiac muscle contraction_Homo sapiens_hsa042601.31336076
32Melanogenesis_Homo sapiens_hsa049161.30860875
33Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.30501653
34Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.26666752
35Dilated cardiomyopathy_Homo sapiens_hsa054141.23093709
36Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.20168036
37Estrogen signaling pathway_Homo sapiens_hsa049151.17883806
38Glioma_Homo sapiens_hsa052141.17223461
39cAMP signaling pathway_Homo sapiens_hsa040241.15008830
40Oocyte meiosis_Homo sapiens_hsa041141.13546492
41ErbB signaling pathway_Homo sapiens_hsa040121.11816079
42cGMP-PKG signaling pathway_Homo sapiens_hsa040221.11066298
43Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.09836135
44Dorso-ventral axis formation_Homo sapiens_hsa043201.00457113
45Phosphatidylinositol signaling system_Homo sapiens_hsa040700.97539150
46Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.95956101
47Type II diabetes mellitus_Homo sapiens_hsa049300.95777384
48Hedgehog signaling pathway_Homo sapiens_hsa043400.95231117
49Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.94907838
50Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.93508070
51Vibrio cholerae infection_Homo sapiens_hsa051100.93320041
52Glucagon signaling pathway_Homo sapiens_hsa049220.92334367
53Maturity onset diabetes of the young_Homo sapiens_hsa049500.92103873
54Vascular smooth muscle contraction_Homo sapiens_hsa042700.92097838
55Wnt signaling pathway_Homo sapiens_hsa043100.87298491
56Alzheimers disease_Homo sapiens_hsa050100.82322707
57Basal cell carcinoma_Homo sapiens_hsa052170.81239932
58Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.80470069
59Nitrogen metabolism_Homo sapiens_hsa009100.79184179
60Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.78509821
61Linoleic acid metabolism_Homo sapiens_hsa005910.77921190
62Thyroid hormone signaling pathway_Homo sapiens_hsa049190.75368843
63Hippo signaling pathway_Homo sapiens_hsa043900.74257851
64Neurotrophin signaling pathway_Homo sapiens_hsa047220.74164241
65alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.73847386
66MAPK signaling pathway_Homo sapiens_hsa040100.73798250
67Phospholipase D signaling pathway_Homo sapiens_hsa040720.73306112
68Circadian rhythm_Homo sapiens_hsa047100.73139172
69Huntingtons disease_Homo sapiens_hsa050160.72878173
70Endometrial cancer_Homo sapiens_hsa052130.72411214
71VEGF signaling pathway_Homo sapiens_hsa043700.72269268
72Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.71780746
73Bile secretion_Homo sapiens_hsa049760.71320113
74Basal transcription factors_Homo sapiens_hsa030220.70861267
75Notch signaling pathway_Homo sapiens_hsa043300.69273171
76Parkinsons disease_Homo sapiens_hsa050120.69154508
77Oxidative phosphorylation_Homo sapiens_hsa001900.68814793
78Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.67161728
79mTOR signaling pathway_Homo sapiens_hsa041500.66725214
80Choline metabolism in cancer_Homo sapiens_hsa052310.65753882
81Insulin signaling pathway_Homo sapiens_hsa049100.65234884
82Ribosome_Homo sapiens_hsa030100.65204578
83Thyroid hormone synthesis_Homo sapiens_hsa049180.63736360
84Rap1 signaling pathway_Homo sapiens_hsa040150.62944100
85Phototransduction_Homo sapiens_hsa047440.62920027
86Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.62536947
87TGF-beta signaling pathway_Homo sapiens_hsa043500.61909242
88Ras signaling pathway_Homo sapiens_hsa040140.61621845
89Longevity regulating pathway - mammal_Homo sapiens_hsa042110.60375081
90Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.59445992
91Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.57402890
92Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.55688481
93Renal cell carcinoma_Homo sapiens_hsa052110.55266443
94Butanoate metabolism_Homo sapiens_hsa006500.54713457
95Lysine degradation_Homo sapiens_hsa003100.53744808
96Alcoholism_Homo sapiens_hsa050340.53631789
97Colorectal cancer_Homo sapiens_hsa052100.53514418
98Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.53288362
99Protein digestion and absorption_Homo sapiens_hsa049740.52219403
100Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.51753015
101Tight junction_Homo sapiens_hsa045300.51707301
102Pancreatic secretion_Homo sapiens_hsa049720.48231479
103Endocytosis_Homo sapiens_hsa041440.48035997
104Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.46983245
105Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.45639681
106Ether lipid metabolism_Homo sapiens_hsa005650.45184556
107Inositol phosphate metabolism_Homo sapiens_hsa005620.44526878
108Central carbon metabolism in cancer_Homo sapiens_hsa052300.44512727
109Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.41818503
110Sphingolipid signaling pathway_Homo sapiens_hsa040710.41796975
111Fatty acid biosynthesis_Homo sapiens_hsa000610.40735146
112Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.39032678
113Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.38798117
114Carbohydrate digestion and absorption_Homo sapiens_hsa049730.37782761
115Ovarian steroidogenesis_Homo sapiens_hsa049130.37485504
116Melanoma_Homo sapiens_hsa052180.36287577
117Non-small cell lung cancer_Homo sapiens_hsa052230.35717930
118ECM-receptor interaction_Homo sapiens_hsa045120.34581380
119AMPK signaling pathway_Homo sapiens_hsa041520.33570082
120ABC transporters_Homo sapiens_hsa020100.33067163
121Proteoglycans in cancer_Homo sapiens_hsa052050.32917805
122Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.32330819
123Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.31571799
124Pathways in cancer_Homo sapiens_hsa052000.31028891
125MicroRNAs in cancer_Homo sapiens_hsa052060.30516651

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