PKP3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the arm-repeat (armadillo) and plakophilin gene families. Plakophilin proteins contain numerous armadillo repeats, localize to cell desmosomes and nuclei, and participate in linking cadherins to intermediate filaments in the cytoskeleton. This protein may act in cellular desmosome-dependent adhesion and signaling pathways. Two transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* desmosome organization (GO:0002934)9.86917434
2keratinization (GO:0031424)9.52909831
3establishment of skin barrier (GO:0061436)9.13061810
4regulation of water loss via skin (GO:0033561)8.58522019
5intermediate filament organization (GO:0045109)6.16598694
6bundle of His cell to Purkinje myocyte communication (GO:0086069)6.06379730
7keratinocyte differentiation (GO:0030216)5.86839981
8multicellular organismal water homeostasis (GO:0050891)5.72041011
9peptide cross-linking (GO:0018149)5.29559439
10keratinocyte development (GO:0003334)5.14123508
11antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.08977433
12antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.08977433
13keratinocyte proliferation (GO:0043616)4.96636298
14epidermis development (GO:0008544)4.76895061
15epidermal cell differentiation (GO:0009913)4.69331686
16water homeostasis (GO:0030104)4.68972194
17antigen processing and presentation of endogenous antigen (GO:0019883)4.61886733
18COPI coating of Golgi vesicle (GO:0048205)4.32205593
19Golgi transport vesicle coating (GO:0048200)4.32205593
20viral transcription (GO:0019083)4.30572178
21positive regulation of Cdc42 GTPase activity (GO:0043089)4.26600871
22thymic T cell selection (GO:0045061)4.23606417
23activation of Rac GTPase activity (GO:0032863)4.20277618
24skin morphogenesis (GO:0043589)4.06134813
25translational termination (GO:0006415)4.05990834
26gap junction assembly (GO:0016264)4.05288602
27interferon-gamma secretion (GO:0072643)3.96688286
28epithelial cell differentiation involved in prostate gland development (GO:0060742)3.93632305
29regulation of ruffle assembly (GO:1900027)3.91353747
30positive thymic T cell selection (GO:0045059)3.90891209
31ribosomal small subunit biogenesis (GO:0042274)3.90201873
32negative regulation of keratinocyte proliferation (GO:0010839)3.83186745
33intermediate filament cytoskeleton organization (GO:0045104)3.74196678
34cytoskeletal anchoring at plasma membrane (GO:0007016)3.71275267
35virion attachment to host cell (GO:0019062)3.65105641
36adhesion of symbiont to host cell (GO:0044650)3.65105641
37ribosomal small subunit assembly (GO:0000028)3.63383217
38planar cell polarity pathway involved in neural tube closure (GO:0090179)3.62418481
39intermediate filament-based process (GO:0045103)3.60968559
40branching involved in mammary gland duct morphogenesis (GO:0060444)3.60479480
41positive regulation of interleukin-8 secretion (GO:2000484)3.59752567
42surfactant homeostasis (GO:0043129)3.56760852
43proline biosynthetic process (GO:0006561)3.52129698
44T cell selection (GO:0045058)3.50059129
45sphingoid metabolic process (GO:0046519)3.45888886
46positive regulation of epidermal cell differentiation (GO:0045606)3.45400870
47polarized epithelial cell differentiation (GO:0030859)3.41663525
48positive regulation of epidermis development (GO:0045684)3.40614376
49regulation of cholesterol homeostasis (GO:2000188)3.36983318
50viral life cycle (GO:0019058)3.34631701
51cell-substrate junction assembly (GO:0007044)3.32371442
52regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.32290983
53translational elongation (GO:0006414)3.29868193
54ectoderm development (GO:0007398)3.26678463
55SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.24991100
56positive T cell selection (GO:0043368)3.22984927
57atrioventricular valve morphogenesis (GO:0003181)3.22961466
58leukocyte aggregation (GO:0070486)3.22485922
59protein targeting to ER (GO:0045047)3.20247429
60negative regulation of cell fate specification (GO:0009996)3.16428237
61cotranslational protein targeting to membrane (GO:0006613)3.13756617
62diol metabolic process (GO:0034311)3.12460227
63dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.11499612
64retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.10474173
65negative thymic T cell selection (GO:0045060)3.10075207
66regulation of cholesterol biosynthetic process (GO:0045540)3.09776176
67negative T cell selection (GO:0043383)3.09743473
68detection of bacterium (GO:0016045)3.08726398
69cellular protein complex disassembly (GO:0043624)3.08723810
70cell-substrate adherens junction assembly (GO:0007045)3.07887622
71focal adhesion assembly (GO:0048041)3.07887622
72establishment of protein localization to endoplasmic reticulum (GO:0072599)3.06029106
73protein localization to endosome (GO:0036010)3.05981762
74morphogenesis of embryonic epithelium (GO:0016331)3.05330827
75ventricular cardiac muscle cell action potential (GO:0086005)3.05272677
76semaphorin-plexin signaling pathway (GO:0071526)3.04460669
77sphingosine metabolic process (GO:0006670)3.04268965
78apoptotic process involved in morphogenesis (GO:0060561)3.04216110
79establishment of tissue polarity (GO:0007164)3.02581442
80establishment of planar polarity (GO:0001736)3.02581442
81GDP-mannose metabolic process (GO:0019673)3.02427236
82positive regulation of gamma-delta T cell activation (GO:0046645)3.01833023
83regulation of chemokine secretion (GO:0090196)2.99939428
84protein localization to endoplasmic reticulum (GO:0070972)2.96813448
85regulation of T cell tolerance induction (GO:0002664)2.96650820
86establishment of apical/basal cell polarity (GO:0035089)2.96200705
87peptidyl-tyrosine autophosphorylation (GO:0038083)2.96063492
88negative regulation of stress fiber assembly (GO:0051497)2.96049464
89adherens junction assembly (GO:0034333)2.96000846
90maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.95750182
91protein retention in ER lumen (GO:0006621)2.93344795
92hair follicle morphogenesis (GO:0031069)2.90116590
93regulation of keratinocyte differentiation (GO:0045616)2.88638504
94nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.87874461
95regulation of hair follicle development (GO:0051797)2.87769648
96negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)2.87088105
97regulation of epidermis development (GO:0045682)2.83542101
98positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.81087606
99positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.76944899
100tumor necrosis factor-mediated signaling pathway (GO:0033209)2.75483592
101adhesion of symbiont to host (GO:0044406)2.75367731
102chemical homeostasis within a tissue (GO:0048875)2.74563405
103endothelial cell chemotaxis (GO:0035767)2.74042958
104regulation of endothelial cell chemotaxis (GO:2001026)2.74021841
105positive regulation of hair cycle (GO:0042635)2.70788279
106positive regulation of hair follicle development (GO:0051798)2.70788279
107tight junction assembly (GO:0070830)2.69933639
108maternal placenta development (GO:0001893)2.69619357
109regulation of gamma-delta T cell differentiation (GO:0045586)2.69596193
110regulation of cardioblast differentiation (GO:0051890)2.68319747
111regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.67939889
112negative regulation of cell fate commitment (GO:0010454)2.67713784
113regulation of gamma-delta T cell activation (GO:0046643)2.65909119
114regulation of viral release from host cell (GO:1902186)2.65672013
115positive regulation of pseudopodium assembly (GO:0031274)2.65564654
116cell differentiation involved in embryonic placenta development (GO:0060706)2.64352295
117negative regulation of T cell mediated immunity (GO:0002710)2.63562687
118NADH metabolic process (GO:0006734)2.62828625
119regulation of interleukin-8 secretion (GO:2000482)2.61732486
120glucose 6-phosphate metabolic process (GO:0051156)2.61513758
121receptor catabolic process (GO:0032801)2.59991640
122detection of other organism (GO:0098543)2.59729342
123calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.59326139
124glucose catabolic process (GO:0006007)2.58835392
125translational initiation (GO:0006413)2.58389648
126skin development (GO:0043588)2.57503866
127protein complex disassembly (GO:0043241)2.56889824
128cell-cell junction maintenance (GO:0045217)2.56245387
129regulation of Cdc42 GTPase activity (GO:0043088)2.55813395
130regulation of early endosome to late endosome transport (GO:2000641)2.55762089
131negative regulation of viral release from host cell (GO:1902187)2.55583381
132gland morphogenesis (GO:0022612)2.54849439
133urea cycle (GO:0000050)2.54340740
134regulation of keratinocyte proliferation (GO:0010837)2.53550440
135phosphatidylserine acyl-chain remodeling (GO:0036150)2.53213162
136regulation of cell proliferation involved in kidney development (GO:1901722)2.53175163
137negative regulation of cell size (GO:0045792)2.52762466
138negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.52669294
139proline metabolic process (GO:0006560)2.52015561
140regulation of natural killer cell differentiation (GO:0032823)2.51360603
141regulation of epidermal cell differentiation (GO:0045604)2.51077157
142* cell junction assembly (GO:0034329)2.49222070
143maturation of SSU-rRNA (GO:0030490)2.48809441
144renal filtration (GO:0097205)2.48707310
145linoleic acid metabolic process (GO:0043651)2.47609311
146regulation of interleukin-12 biosynthetic process (GO:0045075)2.47253838
147* cell-cell junction assembly (GO:0007043)2.47166243
148regulation of fatty acid beta-oxidation (GO:0031998)2.46863935
149positive regulation of keratinocyte differentiation (GO:0045618)2.46697821
150regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.46683829
151regulation of cholesterol metabolic process (GO:0090181)2.46662548
152positive regulation of interleukin-4 production (GO:0032753)2.45045578
153positive regulation of tolerance induction (GO:0002645)2.44063302
154phosphatidylinositol acyl-chain remodeling (GO:0036149)2.43386833
155* cell junction organization (GO:0034330)2.43044906
156intestinal epithelial cell development (GO:0060576)2.41946778
157lymphocyte migration (GO:0072676)2.41678304
158epithelial cell-cell adhesion (GO:0090136)2.41108641
159regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.40202109
160positive regulation of interleukin-1 secretion (GO:0050716)2.39930015
161hair cycle (GO:0042633)11.0162083
162molting cycle (GO:0042303)11.0162083
163hemidesmosome assembly (GO:0031581)10.2698501

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse4.54947100
2* P63_26484246_Chip-Seq_KERATINOCYTES_Human2.72544710
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.70783786
4SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.36019839
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.31237905
6IRF8_22096565_ChIP-ChIP_GC-B_Human2.19837618
7SOX9_24532713_ChIP-Seq_HFSC_Mouse2.11037248
8ESR1_21235772_ChIP-Seq_MCF-7_Human2.07505374
9TP63_17297297_ChIP-ChIP_HaCaT_Human14.9195296
10ZNF263_19887448_ChIP-Seq_K562_Human1.99675014
11SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.96698307
12SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.96698307
13IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.95749717
14STAT6_21828071_ChIP-Seq_BEAS2B_Human1.92634490
15CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.91665342
16STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.85766210
17CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.84274076
18ESR2_21235772_ChIP-Seq_MCF-7_Human1.71445627
19FOXO3_23340844_ChIP-Seq_DLD1_Human1.65681273
20STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.56521808
21SOX2_20726797_ChIP-Seq_SW620_Human1.55479185
22* RACK7_27058665_Chip-Seq_MCF-7_Human1.52761444
23RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.48079002
24NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.46740453
25RUNX_20019798_ChIP-Seq_JUKART_Human1.46678973
26CLOCK_20551151_ChIP-Seq_293T_Human1.45071539
27CDX2_20551321_ChIP-Seq_CACO-2_Human1.44495375
28SRY_22984422_ChIP-ChIP_TESTIS_Rat1.43916033
29ERG_21242973_ChIP-ChIP_JURKAT_Human1.43058210
30ATF3_27146783_Chip-Seq_COLON_Human1.40352180
31* BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.39975377
32CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.38425259
33KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.38333908
34RUNX1_27514584_Chip-Seq_MCF-7_Human1.38307907
35TRIM28_21343339_ChIP-Seq_HEK293_Human1.38249159
36* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.37112490
37P300_27058665_Chip-Seq_ZR-75-30cells_Human1.35631736
38LXR_22292898_ChIP-Seq_THP-1_Human1.35264705
39SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.34573037
40* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.33229798
41SMC4_20622854_ChIP-Seq_HELA_Human1.33155310
42PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.32462250
43CREB1_26743006_Chip-Seq_LNCaP_Human1.32352270
44ESR1_20079471_ChIP-ChIP_T-47D_Human1.31786334
45* GATA6_25053715_ChIP-Seq_YYC3_Human1.31418706
46TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.30931716
47ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.29867816
48AR_21909140_ChIP-Seq_LNCAP_Human1.29662864
49EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.29339737
50KDM2B_26808549_Chip-Seq_K562_Human1.28882700
51GATA4_25053715_ChIP-Seq_YYC3_Human1.26815980
52NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.26100975
53TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.24590489
54UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.24312513
55KLF4_18555785_ChIP-Seq_MESCs_Mouse1.23300574
56DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.22971412
57EGR1_19032775_ChIP-ChIP_M12_Human1.22506935
58* MAF_26560356_Chip-Seq_TH1_Human1.22362416
59ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.22316621
60SOX2_27498859_Chip-Seq_STOMACH_Mouse1.22195947
61RARG_19884340_ChIP-ChIP_MEFs_Mouse1.21636873
62KLF5_25053715_ChIP-Seq_YYC3_Human1.20677467
63TET1_21451524_ChIP-Seq_MESCs_Mouse1.20675809
64* TP63_22573176_ChIP-Seq_HFKS_Human1.19496558
65TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.16828745
66RXR_22158963_ChIP-Seq_LIVER_Mouse1.15619262
67PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.13764035
68ESR1_15608294_ChIP-ChIP_MCF-7_Human1.13544617
69NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.13454038
70ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.13266322
71SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.12663215
72* ELK3_25401928_ChIP-Seq_HUVEC_Human1.11387222
73RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.11327727
74TCF7_22412390_ChIP-Seq_EML_Mouse1.10927345
75FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.10716930
76UTX_26944678_Chip-Seq_JUKART_Human1.10565237
77STAT3_1855785_ChIP-Seq_MESCs_Mouse1.08109180
78HIF1A_21447827_ChIP-Seq_MCF-7_Human1.06994643
79FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.06495934
80MYB_26560356_Chip-Seq_TH2_Human1.06114053
81* SA1_27219007_Chip-Seq_ERYTHROID_Human1.05713241
82TCF4_18268006_ChIP-ChIP_LS174T_Human1.05454626
83IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.03553958
84TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.02746794
85* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.01481692
86CHD1_26751641_Chip-Seq_LNCaP_Human1.00521135
87* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.00312837
88POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.00089424
89FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.99326248
90EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.99224229
91GATA3_24758297_ChIP-Seq_MCF-7_Human0.98948533
92TP53_22127205_ChIP-Seq_IMR90_Human0.97753905
93ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.96063558
94* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.94936890
95NANOG_18555785_ChIP-Seq_MESCs_Mouse0.93534704
96TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.92541488
97* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.92414580
98KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.92192834
99TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.91701473
100NCOR1_26117541_ChIP-Seq_K562_Human0.91460170
101KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.90916298
102UBF1/2_26484160_Chip-Seq_HMECs_Human0.89317860
103SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.88992044
104* DNAJC2_21179169_ChIP-ChIP_NT2_Human0.88941890
105TP63_23658742_ChIP-Seq_EP156T_Human0.88356885
106THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.87120559
107* BCOR_27268052_Chip-Seq_Bcells_Human0.86374583
108CEBPB_22108803_ChIP-Seq_LS180_Human0.86315286
109MYC_22102868_ChIP-Seq_BL_Human0.86149377
110* CTCF_20526341_ChIP-Seq_ESCs_Human0.85971359
111VDR_21846776_ChIP-Seq_THP-1_Human0.85577083
112MAF_26560356_Chip-Seq_TH2_Human0.84810304
113* BCL6_27268052_Chip-Seq_Bcells_Human0.84655039
114PPARA_22158963_ChIP-Seq_LIVER_Mouse0.83607093
115GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.82953792
116KDM2B_26808549_Chip-Seq_DND41_Human0.82724911
117RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.82383146
118HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.82082062
119* CTCF_27219007_Chip-Seq_Bcells_Human0.81898155
120NANOG_20526341_ChIP-Seq_ESCs_Human0.81529637
121PPAR_26484153_Chip-Seq_NCI-H1993_Human0.81068663
122KDM2B_26808549_Chip-Seq_SUP-B15_Human0.81028227
123P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.79427145
124MYB_26560356_Chip-Seq_TH1_Human0.79363028
125BRD4_27068464_Chip-Seq_AML-cells_Mouse0.77391033
126RUNX1_22412390_ChIP-Seq_EML_Mouse0.77278229
127CJUN_26792858_Chip-Seq_BT549_Human0.76379325
128ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.76147343
129SA1_27219007_Chip-Seq_Bcells_Human0.74753764
130RXR_22108803_ChIP-Seq_LS180_Human0.73498634
131CTCF_27219007_Chip-Seq_ERYTHROID_Human0.73389811
132* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.73149009
133* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.72639718
134* P68_20966046_ChIP-Seq_HELA_Human0.72632517
135GATA6_21074721_ChIP-Seq_CACO-2_Human0.70443767
136E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.69609834
137VDR_24763502_ChIP-Seq_THP-1_Human0.68784023
138SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.67896623

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002796_impaired_skin_barrier6.23832384
2MP0000579_abnormal_nail_morphology4.24414151
3MP0005275_abnormal_skin_tensile4.10657798
4MP0005501_abnormal_skin_physiology3.98553187
5MP0002098_abnormal_vibrissa_morphology3.60450255
6MP0002254_reproductive_system_inflammat3.53879282
7MP0004381_abnormal_hair_follicle3.33421898
8* MP0001216_abnormal_epidermal_layer3.26493703
9MP0002060_abnormal_skin_morphology3.18673506
10* MP0010234_abnormal_vibrissa_follicle3.13312183
11MP0003941_abnormal_skin_development3.11413853
12* MP0000383_abnormal_hair_follicle2.87705185
13* MP0010678_abnormal_skin_adnexa2.82243660
14MP0000647_abnormal_sebaceous_gland2.69592539
15MP0003705_abnormal_hypodermis_morpholog2.66527271
16* MP0004947_skin_inflammation2.65112355
17* MP0003453_abnormal_keratinocyte_physiol2.63167385
18MP0000467_abnormal_esophagus_morphology2.53147889
19* MP0000377_abnormal_hair_follicle2.51475981
20* MP0010771_integument_phenotype2.46496904
21MP0003763_abnormal_thymus_physiology2.28343463
22MP0000427_abnormal_hair_cycle2.27815510
23MP0000762_abnormal_tongue_morphology2.04069908
24MP0002234_abnormal_pharynx_morphology1.85087854
25MP0000678_abnormal_parathyroid_gland1.82682154
26MP0002166_altered_tumor_susceptibility1.70438747
27MP0003566_abnormal_cell_adhesion1.70126926
28MP0001243_abnormal_dermal_layer1.68878481
29* MP0009931_abnormal_skin_appearance1.65628905
30MP0001191_abnormal_skin_condition1.63314557
31MP0000685_abnormal_immune_system1.50823694
32MP0005360_urolithiasis1.50570645
33MP0004858_abnormal_nervous_system1.48375166
34MP0001346_abnormal_lacrimal_gland1.47799402
35MP0004264_abnormal_extraembryonic_tissu1.46670002
36MP0002009_preneoplasia1.46315025
37* MP0000367_abnormal_coat/_hair1.46305008
38MP0009379_abnormal_foot_pigmentation1.46217301
39MP0003866_abnormal_defecation1.44779532
40MP0005671_abnormal_response_to1.44273254
41MP0001873_stomach_inflammation1.43241016
42MP0010155_abnormal_intestine_physiology1.42379897
43MP0002006_tumorigenesis1.41033648
44MP0009785_altered_susceptibility_to1.40161268
45MP0010352_gastrointestinal_tract_polyps1.34918105
46MP0000566_synostosis1.33175490
47MP0005023_abnormal_wound_healing1.31987486
48MP0001849_ear_inflammation1.29646746
49MP0009780_abnormal_chondrocyte_physiolo1.27835042
50MP0001851_eye_inflammation1.22675327
51MP0008260_abnormal_autophagy1.21347125
52MP0001800_abnormal_humoral_immune1.16258051
53MP0004185_abnormal_adipocyte_glucose1.14321718
54MP0001790_abnormal_immune_system1.13489230
55MP0005387_immune_system_phenotype1.13489230
56MP0000465_gastrointestinal_hemorrhage1.12495519
57MP0001835_abnormal_antigen_presentation1.12495005
58MP0004272_abnormal_basement_membrane1.11387650
59MP0005000_abnormal_immune_tolerance1.08998241
60MP0003436_decreased_susceptibility_to1.05850741
61MP0000462_abnormal_digestive_system1.05468721
62MP0005025_abnormal_response_to1.04851605
63MP0005451_abnormal_body_composition1.01768727
64MP0002148_abnormal_hypersensitivity_rea1.00577248
65MP0005666_abnormal_adipose_tissue0.99081012
66MP0003300_gastrointestinal_ulcer0.97690152
67MP0009053_abnormal_anal_canal0.97189807
68MP0005257_abnormal_intraocular_pressure0.96264031
69MP0003724_increased_susceptibility_to0.95607513
70MP0009840_abnormal_foam_cell0.95265971
71MP0002249_abnormal_larynx_morphology0.94541320
72MP0000627_abnormal_mammary_gland0.94118513
73MP0002420_abnormal_adaptive_immunity0.90903195
74MP0001819_abnormal_immune_cell0.89922218
75MP0003191_abnormal_cellular_cholesterol0.89483855
76MP0002723_abnormal_immune_serum0.88928737
77MP0001666_abnormal_nutrient_absorption0.87607524
78MP0002452_abnormal_antigen_presenting0.83486827
79MP0005076_abnormal_cell_differentiation0.83252526
80MP0002089_abnormal_postnatal_growth/wei0.83094919
81MP0001340_abnormal_eyelid_morphology0.80940069
82MP0000477_abnormal_intestine_morphology0.80268362
83MP0001765_abnormal_ion_homeostasis0.78958618
84MP0003045_fibrosis0.77904532
85MP0009333_abnormal_splenocyte_physiolog0.77227433
86MP0005375_adipose_tissue_phenotype0.76676744
87MP0006054_spinal_hemorrhage0.74124236
88MP0002111_abnormal_tail_morphology0.74014302
89MP0000858_altered_metastatic_potential0.72573209
90MP0001881_abnormal_mammary_gland0.72297147
91MP0003315_abnormal_perineum_morphology0.71426632
92MP0000003_abnormal_adipose_tissue0.71008962
93MP0003123_paternal_imprinting0.70856126
94MP0002405_respiratory_system_inflammati0.70388423
95MP0000490_abnormal_crypts_of0.70345693
96MP0000537_abnormal_urethra_morphology0.69493454
97MP0001853_heart_inflammation0.67988766
98MP0005083_abnormal_biliary_tract0.67906409
99MP0005058_abnormal_lysosome_morphology0.67275727
100MP0000613_abnormal_salivary_gland0.67270411
101MP0000538_abnormal_urinary_bladder0.64557906
102MP0001845_abnormal_inflammatory_respons0.64250728
103MP0002095_abnormal_skin_pigmentation0.63862499
104MP0002896_abnormal_bone_mineralization0.63527452
105MP0005409_darkened_coat_color0.63384589
106MP0004957_abnormal_blastocyst_morpholog0.63332911
107MP0000470_abnormal_stomach_morphology0.62957619
108MP0005310_abnormal_salivary_gland0.62950289
109MP0002398_abnormal_bone_marrow0.62822018
110MP0005075_abnormal_melanosome_morpholog0.61390598
111MP0001664_abnormal_digestion0.60687203
112MP0000716_abnormal_immune_system0.60429525
113MP0004782_abnormal_surfactant_physiolog0.60229081
114MP0003693_abnormal_embryo_hatching0.59680910
115MP0003448_altered_tumor_morphology0.59159378
116MP0002877_abnormal_melanocyte_morpholog0.58350621
117MP0001188_hyperpigmentation0.57887954
118* MP0002722_abnormal_immune_system0.56805117
119MP0002086_abnormal_extraembryonic_tissu0.56275206
120MP0002933_joint_inflammation0.56062267
121MP0010030_abnormal_orbit_morphology0.55949777
122MP0004019_abnormal_vitamin_homeostasis0.55058158
123MP0002277_abnormal_respiratory_mucosa0.55030166
124MP0000703_abnormal_thymus_morphology0.53762123
125MP0009643_abnormal_urine_homeostasis0.51936555
126MP0002132_abnormal_respiratory_system0.51662010
127MP0004043_abnormal_pH_regulation0.50071509
128MP0001730_embryonic_growth_arrest0.49106953
129MP0008789_abnormal_olfactory_epithelium0.49093175
130MP0005377_hearing/vestibular/ear_phenot0.47961311
131MP0003878_abnormal_ear_physiology0.47961311
132MP0004197_abnormal_fetal_growth/weight/0.47811618
133MP0003638_abnormal_response/metabolism_0.47318937
134MP0006138_congestive_heart_failure0.47234752
135MP0003755_abnormal_palate_morphology0.44039057
136MP0001348_abnormal_lacrimal_gland0.42919027
137MP0003091_abnormal_cell_migration0.42424899
138MP0002282_abnormal_trachea_morphology0.41937563
139MP0005621_abnormal_cell_physiology0.40172529
140MP0003183_abnormal_peptide_metabolism0.39728375

Predicted human phenotypes

RankGene SetZ-score
1Hypotrichosis (HP:0001006)7.31212996
2Fragile nails (HP:0001808)7.10400583
3Milia (HP:0001056)7.02664901
4Woolly hair (HP:0002224)6.68161488
5Plantar hyperkeratosis (HP:0007556)6.58954408
6Onycholysis (HP:0001806)6.46322691
7Pili torti (HP:0003777)6.40279873
8Right ventricular cardiomyopathy (HP:0011663)5.42127442
9Increased IgE level (HP:0003212)5.40014253
10Palmoplantar hyperkeratosis (HP:0000972)5.34839113
11Abnormality of nail color (HP:0100643)5.30740293
12Palmar hyperkeratosis (HP:0010765)5.08081122
13Nail dystrophy (HP:0008404)4.95526614
14Thick nail (HP:0001805)4.88805966
15Atrophic scars (HP:0001075)4.52958012
16Abnormal blistering of the skin (HP:0008066)4.29291173
17Abnormal hair laboratory examination (HP:0003328)4.23249042
18Alopecia of scalp (HP:0002293)4.16756472
19Erythema (HP:0010783)3.99524998
20Congenital ichthyosiform erythroderma (HP:0007431)3.89304974
21Lip pit (HP:0100267)3.85595561
22Ridged nail (HP:0001807)3.30048512
23Sparse eyelashes (HP:0000653)3.29678768
24Parakeratosis (HP:0001036)3.29015514
25Erythroderma (HP:0001019)3.21539144
26Ectropion (HP:0000656)2.90835830
27Aplasia cutis congenita (HP:0001057)2.87350388
28Pustule (HP:0200039)2.84300510
29Curly hair (HP:0002212)2.83308753
30Gangrene (HP:0100758)2.82506184
31Corneal erosion (HP:0200020)2.76297249
32Blepharitis (HP:0000498)2.74749057
33Conjunctival hamartoma (HP:0100780)2.69401029
34Selective tooth agenesis (HP:0001592)2.68011012
35Flat acetabular roof (HP:0003180)2.66813451
36Abnormality of the neuromuscular junction (HP:0003398)2.63102424
37Fatigable weakness (HP:0003473)2.63102424
38Fragile skin (HP:0001030)2.59526504
39Ventricular tachycardia (HP:0004756)2.59435358
40Ankyloglossia (HP:0010296)2.59038544
41Septate vagina (HP:0001153)2.57873441
42Elevated erythrocyte sedimentation rate (HP:0003565)2.56415382
43Pruritus (HP:0000989)2.55285763
44Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.54999209
45Chronic otitis media (HP:0000389)2.51344804
46Hypohidrosis (HP:0000966)2.51336643
47Eczematoid dermatitis (HP:0000976)2.47092692
48Oral leukoplakia (HP:0002745)2.44925523
49Brittle hair (HP:0002299)2.39652597
50Broad face (HP:0000283)2.37821475
51Abnormality of the distal phalanges of the toes (HP:0010182)2.36343731
52Distal lower limb muscle weakness (HP:0009053)2.36296618
53Skin ulcer (HP:0200042)2.36269225
54Hypergammaglobulinemia (HP:0010702)2.32349879
55Palmoplantar keratoderma (HP:0000982)2.30553867
56Distal lower limb amyotrophy (HP:0008944)2.29853910
57Absent eyelashes (HP:0000561)2.29497100
58Advanced eruption of teeth (HP:0006288)2.29345571
59Hypoplasia of dental enamel (HP:0006297)2.28789382
60Follicular hyperkeratosis (HP:0007502)2.26833137
61Natal tooth (HP:0000695)2.23895580
62Nasal polyposis (HP:0100582)2.20967867
63Autoimmune hemolytic anemia (HP:0001890)2.18331504
64Myositis (HP:0100614)2.17517735
65Down-sloping shoulders (HP:0200021)2.17458494
66Pterygium (HP:0001059)2.17373440
67Thin bony cortex (HP:0002753)2.15611072
68Acanthosis nigricans (HP:0000956)2.14664714
69Sparse scalp hair (HP:0002209)2.14538828
70Abnormality of the gastric mucosa (HP:0004295)2.13628847
71Abnormality of hair growth rate (HP:0011363)2.11636448
72Slow-growing hair (HP:0002217)2.11636448
73Hyperhidrosis (HP:0000975)2.08838655
74Hyperactive renin-angiotensin system (HP:0000841)2.07518641
75Mildly elevated creatine phosphokinase (HP:0008180)2.06928053
76Abnormality of the axillary hair (HP:0100134)2.05718612
77Abnormality of secondary sexual hair (HP:0009888)2.05718612
78Popliteal pterygium (HP:0009756)2.05680305
79Ureteral stenosis (HP:0000071)2.05581104
80Villous atrophy (HP:0011473)2.04470996
81Abnormality of small intestinal villus morphology (HP:0011472)2.04470996
82Amelogenesis imperfecta (HP:0000705)2.04090152
83Neonatal death (HP:0003811)2.03705199
84Abnormality of oral frenula (HP:0000190)2.02162189
85Hyperacusis (HP:0010780)2.01259205
86Orchitis (HP:0100796)2.00088101
87Congenital, generalized hypertrichosis (HP:0004540)1.99307188
88Recurrent bronchitis (HP:0002837)1.98989729
89Dehydration (HP:0001944)1.97759305
90Abnormality of cells of the erythroid lineage (HP:0012130)1.97117075
91Esophageal atresia (HP:0002032)1.96661822
92Short nail (HP:0001799)1.95221661
93Axonal loss (HP:0003447)1.93601709
94Anonychia (HP:0001798)1.90537867
95Oligodontia (HP:0000677)1.90065089
96Nasolacrimal duct obstruction (HP:0000579)1.88319506
97Dry hair (HP:0011359)1.87813042
98Abnormality of permanent molar morphology (HP:0011071)1.87345775
99Abnormality of the dental root (HP:0006486)1.87345775
100Taurodontia (HP:0000679)1.87345775
101Achilles tendon contracture (HP:0001771)1.81599864
102Abnormality of the nasal mucosa (HP:0000433)1.81353218
103Cheilitis (HP:0100825)1.80218532
104Keratoconjunctivitis sicca (HP:0001097)1.80097058
105Ureteral obstruction (HP:0006000)1.80070818
106Hypoplastic labia majora (HP:0000059)1.79172918
107Abnormality of the fingernails (HP:0001231)1.77931145
108Focal segmental glomerulosclerosis (HP:0000097)1.77000814
109Hyporeflexia of lower limbs (HP:0002600)1.76938522
110Breast hypoplasia (HP:0003187)1.76896822
111Amniotic constriction ring (HP:0009775)1.76039690
112Abnormality of placental membranes (HP:0011409)1.76039690
113Hyperparathyroidism (HP:0000843)1.74395189
114Upper limb amyotrophy (HP:0009129)1.72854495
115Distal upper limb amyotrophy (HP:0007149)1.72854495
116Keratoconjunctivitis (HP:0001096)1.72368503
117Increased connective tissue (HP:0009025)1.71051015
118Reticulocytopenia (HP:0001896)1.70276271
119Abnormality of molar (HP:0011077)1.70245832
120Abnormality of molar morphology (HP:0011070)1.70245832
121Severe combined immunodeficiency (HP:0004430)1.68729022
122Abnormal number of erythroid precursors (HP:0012131)1.67610166
123Ureteral duplication (HP:0000073)1.67250068
124Myopathic facies (HP:0002058)1.65203788
125Trismus (HP:0000211)1.64788309
126Abnormality of the Achilles tendon (HP:0005109)1.63553267
127Rectal prolapse (HP:0002035)1.63243983
128Deviation of the thumb (HP:0009603)1.60903679
129Abnormality of the salivary glands (HP:0010286)1.60737148
130Sepsis (HP:0100806)1.60013632
131Combined immunodeficiency (HP:0005387)1.59035363
132Abdominal distention (HP:0003270)1.58970320
133Concave nail (HP:0001598)1.58677453
134Abnormality of T cell physiology (HP:0011840)1.58621525
135Germ cell neoplasia (HP:0100728)1.58605272
136Abnormality of the distal phalanx of the thumb (HP:0009617)1.58535718
137Abnormality of the dental pulp (HP:0006479)1.58309815
138Carious teeth (HP:0000670)1.57671475
139Abnormality of the labia majora (HP:0012881)1.57340686
140Malnutrition (HP:0004395)1.56910130
141Abnormality of T cells (HP:0002843)1.55922724

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST1R3.88363031
2MST43.62899567
3MAPKAPK33.15232321
4MAP3K32.96884379
5ERN12.78420740
6IRAK32.76104762
7SMG12.73552658
8MAP4K12.71492162
9EPHA22.67322659
10FGFR42.44238811
11RPS6KB22.33903951
12TXK2.24477360
13STK102.23958656
14PIK3CA2.19192983
15TYK22.08579919
16MAP3K22.08463517
17RIPK12.02956734
18EPHB22.01978522
19FER1.96133725
20MAP3K141.86315457
21ICK1.80405847
22LRRK21.80333420
23EEF2K1.79406497
24IKBKE1.79348234
25MAP2K21.79100262
26TAOK11.71031503
27ITK1.65397542
28ZAP701.63948724
29PAK41.63067279
30MAP2K61.61418615
31BLK1.52747155
32TESK11.50034035
33MAP3K61.45315905
34FGFR31.44227369
35TBK11.42055580
36NLK1.41909806
37JAK31.32514221
38MAP3K11.30904654
39EPHA31.29439919
40NME11.27818216
41ARAF1.27293282
42PIM21.26918594
43EPHB11.19308797
44JAK11.19078130
45TRIB31.16319832
46LATS21.14765836
47TRPM71.11383444
48CDK121.09319879
49PTK61.04255988
50RPS6KA41.02349754
51PIK3CG1.00191395
52GRK60.99624601
53MUSK0.96578364
54PKN20.96494163
55PRKCI0.95843934
56BMX0.94697549
57PRPF4B0.93446934
58MAP3K120.93156644
59MAP3K110.92210308
60MAP3K90.90918207
61LCK0.90609578
62BTK0.90465277
63MAPKAPK20.89919610
64TGFBR20.88849930
65PDGFRA0.87081713
66MTOR0.85880122
67MAP2K30.85123596
68NME20.84533037
69FGFR10.83809278
70FRK0.81918075
71MET0.81651629
72IKBKB0.80762143
73SCYL20.79737611
74CHUK0.79206672
75KDR0.79021285
76IRAK20.77352531
77TTN0.76525412
78PTK20.76325551
79PRKD20.75267648
80MAP3K70.73283865
81STK240.73074768
82TEC0.72987541
83HCK0.69849425
84SYK0.68211862
85MAPK150.65250132
86NTRK10.63187382
87MAP3K100.63064067
88TESK20.61141754
89CSK0.60661143
90FGFR20.60583500
91KSR20.58855552
92SIK10.58367104
93PRKD30.55956306
94MYLK0.55229777
95RPS6KA20.54926885
96JAK20.53766797
97NEK60.50705998
98DYRK1B0.50098479
99CDK70.48814686
100BRAF0.48714758
101LATS10.46651666
102MAP3K80.44879137
103STK380.44817149
104CDK60.44304719
105CDC42BPA0.43820935
106LMTK20.43552168
107PRKG20.42789322
108EIF2AK10.42779525
109PDPK10.41781756
110ILK0.41528367
111MARK20.40623045
112RPS6KA10.39158831
113MAPK110.38909023
114STK390.38376292
115KIT0.38152461
116PBK0.37214344
117MAP2K10.37175502
118RET0.37121136
119IRAK10.36387169
120TAOK30.33332462
121CAMK2G0.32834277
122DMPK0.31043408
123PRKD10.30939988
124ERBB20.30769886
125TGFBR10.30639594
126PIM10.29899211
127LYN0.29312299
128SRC0.29005929
129PRKCQ0.28520446
130RIPK40.26401076
131HIPK20.26332319
132MATK0.25112549
133LIMK10.24847721
134AURKB0.24362663
135TAOK20.23711302
136IRAK40.23473289
137RPS6KL10.21850198
138RPS6KC10.21850198
139MAPKAPK50.21058908
140MAP3K130.20360337
141ABL20.20108246
142CAMK1D0.19008071
143PDGFRB0.16890169

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053403.81126516
2Ribosome_Homo sapiens_hsa030103.30805170
3Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.66658115
4Fructose and mannose metabolism_Homo sapiens_hsa000512.64576471
5Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.60344481
6Cyanoamino acid metabolism_Homo sapiens_hsa004602.60042193
7Antigen processing and presentation_Homo sapiens_hsa046122.39145766
8T cell receptor signaling pathway_Homo sapiens_hsa046602.17443673
9Intestinal immune network for IgA production_Homo sapiens_hsa046722.09013869
10Graft-versus-host disease_Homo sapiens_hsa053322.08847224
11Arginine biosynthesis_Homo sapiens_hsa002201.99562870
12Galactose metabolism_Homo sapiens_hsa000521.94825479
13Linoleic acid metabolism_Homo sapiens_hsa005911.94226924
14alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.90585597
15Hematopoietic cell lineage_Homo sapiens_hsa046401.90359638
16Central carbon metabolism in cancer_Homo sapiens_hsa052301.81670235
17Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.79229115
18Pentose phosphate pathway_Homo sapiens_hsa000301.76766396
19Fatty acid biosynthesis_Homo sapiens_hsa000611.71868575
20Toxoplasmosis_Homo sapiens_hsa051451.69789658
21Leukocyte transendothelial migration_Homo sapiens_hsa046701.66289468
222-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.65721767
23Fat digestion and absorption_Homo sapiens_hsa049751.62590299
24NF-kappa B signaling pathway_Homo sapiens_hsa040641.60434969
25Jak-STAT signaling pathway_Homo sapiens_hsa046301.60422932
26Sphingolipid metabolism_Homo sapiens_hsa006001.57646626
27Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.56882855
28Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.45665664
29Allograft rejection_Homo sapiens_hsa053301.44775518
30Biosynthesis of amino acids_Homo sapiens_hsa012301.39542665
31Leishmaniasis_Homo sapiens_hsa051401.39429076
32Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.39139000
33ECM-receptor interaction_Homo sapiens_hsa045121.38081869
34Measles_Homo sapiens_hsa051621.37628937
35RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.35736767
36Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.33129533
37Mineral absorption_Homo sapiens_hsa049781.31638404
38Hepatitis C_Homo sapiens_hsa051601.30517867
39Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.28638910
40Basal cell carcinoma_Homo sapiens_hsa052171.28152289
41Arachidonic acid metabolism_Homo sapiens_hsa005901.27767354
42Protein digestion and absorption_Homo sapiens_hsa049741.26749872
43p53 signaling pathway_Homo sapiens_hsa041151.24149772
44Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.23654091
45Insulin signaling pathway_Homo sapiens_hsa049101.21406817
46Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.21225357
47Chronic myeloid leukemia_Homo sapiens_hsa052201.19211823
48Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.17516335
49VEGF signaling pathway_Homo sapiens_hsa043701.16812140
50Osteoclast differentiation_Homo sapiens_hsa043801.14699140
51Bladder cancer_Homo sapiens_hsa052191.14142639
52Histidine metabolism_Homo sapiens_hsa003401.13797652
53Adherens junction_Homo sapiens_hsa045201.11885197
54Endometrial cancer_Homo sapiens_hsa052131.11874903
55Small cell lung cancer_Homo sapiens_hsa052221.10559341
56GnRH signaling pathway_Homo sapiens_hsa049121.08348384
57Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.07972415
58Arginine and proline metabolism_Homo sapiens_hsa003301.06701997
59ErbB signaling pathway_Homo sapiens_hsa040121.05939287
60Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.04227817
61Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.01708398
62Apoptosis_Homo sapiens_hsa042101.01230730
63Tight junction_Homo sapiens_hsa045301.00668735
64Acute myeloid leukemia_Homo sapiens_hsa052211.00428099
65Sulfur metabolism_Homo sapiens_hsa009200.99402804
66Caffeine metabolism_Homo sapiens_hsa002320.99131631
67TNF signaling pathway_Homo sapiens_hsa046680.98421297
68Amoebiasis_Homo sapiens_hsa051460.97601636
69Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.97047997
70Autoimmune thyroid disease_Homo sapiens_hsa053200.96254393
71Pancreatic secretion_Homo sapiens_hsa049720.95904988
72Phenylalanine metabolism_Homo sapiens_hsa003600.94888005
73AMPK signaling pathway_Homo sapiens_hsa041520.94273293
74Thyroid cancer_Homo sapiens_hsa052160.93691127
75Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.92770979
76B cell receptor signaling pathway_Homo sapiens_hsa046620.91537023
77Viral myocarditis_Homo sapiens_hsa054160.90560823
78Influenza A_Homo sapiens_hsa051640.90287668
79Pertussis_Homo sapiens_hsa051330.90170729
80Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.88660947
81Salmonella infection_Homo sapiens_hsa051320.88409021
82Proteoglycans in cancer_Homo sapiens_hsa052050.88202606
83Insulin resistance_Homo sapiens_hsa049310.87956273
84Pentose and glucuronate interconversions_Homo sapiens_hsa000400.86881493
85Thyroid hormone signaling pathway_Homo sapiens_hsa049190.86620028
86NOD-like receptor signaling pathway_Homo sapiens_hsa046210.86307098
87Carbon metabolism_Homo sapiens_hsa012000.86011229
88Herpes simplex infection_Homo sapiens_hsa051680.85833505
89Glycerophospholipid metabolism_Homo sapiens_hsa005640.85454980
90Starch and sucrose metabolism_Homo sapiens_hsa005000.85163717
91N-Glycan biosynthesis_Homo sapiens_hsa005100.84995117
92Vibrio cholerae infection_Homo sapiens_hsa051100.83001065
93Drug metabolism - other enzymes_Homo sapiens_hsa009830.81335396
94Bile secretion_Homo sapiens_hsa049760.79665840
95Chemical carcinogenesis_Homo sapiens_hsa052040.78674076
96Notch signaling pathway_Homo sapiens_hsa043300.77486134
97MicroRNAs in cancer_Homo sapiens_hsa052060.77031294
98HTLV-I infection_Homo sapiens_hsa051660.76524194
99Renal cell carcinoma_Homo sapiens_hsa052110.75770562
100Tyrosine metabolism_Homo sapiens_hsa003500.75708137
101Platelet activation_Homo sapiens_hsa046110.74770870
102Phosphatidylinositol signaling system_Homo sapiens_hsa040700.74508912
103Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.74405148
104Toll-like receptor signaling pathway_Homo sapiens_hsa046200.74268144
105AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.74131988
106Choline metabolism in cancer_Homo sapiens_hsa052310.73579787
107Glutathione metabolism_Homo sapiens_hsa004800.73512114
108Hippo signaling pathway_Homo sapiens_hsa043900.73312190
109Inositol phosphate metabolism_Homo sapiens_hsa005620.73304852
110Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.73082898
111Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.72610618
112Ether lipid metabolism_Homo sapiens_hsa005650.71855280
113Axon guidance_Homo sapiens_hsa043600.71472121
114Non-small cell lung cancer_Homo sapiens_hsa052230.70037266
115Shigellosis_Homo sapiens_hsa051310.68257862
116Steroid biosynthesis_Homo sapiens_hsa001000.67309689
117Vitamin digestion and absorption_Homo sapiens_hsa049770.66354868
118Malaria_Homo sapiens_hsa051440.64554186
119Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.64345010
120Endocytosis_Homo sapiens_hsa041440.64244415
121PPAR signaling pathway_Homo sapiens_hsa033200.63790575
122Glucagon signaling pathway_Homo sapiens_hsa049220.63465210
123Asthma_Homo sapiens_hsa053100.62467727
124Tuberculosis_Homo sapiens_hsa051520.61986381
125Legionellosis_Homo sapiens_hsa051340.60738865
126Pyruvate metabolism_Homo sapiens_hsa006200.59680358
127Hedgehog signaling pathway_Homo sapiens_hsa043400.57858952
128Glioma_Homo sapiens_hsa052140.57635264
129Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.56039921
130Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.55845249
131Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.55548547
132Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.55198058
133mTOR signaling pathway_Homo sapiens_hsa041500.55104642
134Pathways in cancer_Homo sapiens_hsa052000.54812454
135Staphylococcus aureus infection_Homo sapiens_hsa051500.53541577
136Estrogen signaling pathway_Homo sapiens_hsa049150.53467208
137Prolactin signaling pathway_Homo sapiens_hsa049170.51201488
138ABC transporters_Homo sapiens_hsa020100.50073139
139Prion diseases_Homo sapiens_hsa050200.50023204
140Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.49989407
141Adipocytokine signaling pathway_Homo sapiens_hsa049200.49592859
142Fatty acid metabolism_Homo sapiens_hsa012120.47759390
143Focal adhesion_Homo sapiens_hsa045100.47610120
144Ovarian steroidogenesis_Homo sapiens_hsa049130.47421161
145Hepatitis B_Homo sapiens_hsa051610.46886665
146Regulation of actin cytoskeleton_Homo sapiens_hsa048100.46783336
147Transcriptional misregulation in cancer_Homo sapiens_hsa052020.46027820
148Renin-angiotensin system_Homo sapiens_hsa046140.45744451
149Sphingolipid signaling pathway_Homo sapiens_hsa040710.45556665
150Glycerolipid metabolism_Homo sapiens_hsa005610.44452331
151Chemokine signaling pathway_Homo sapiens_hsa040620.43583632
152Sulfur relay system_Homo sapiens_hsa041220.43465288
153Retinol metabolism_Homo sapiens_hsa008300.42975892
154Pancreatic cancer_Homo sapiens_hsa052120.42787748
155Other glycan degradation_Homo sapiens_hsa005110.42747564
156Fatty acid elongation_Homo sapiens_hsa000620.42318903

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