PLA1A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a phospholipase that hydrolyzes fatty acids at the sn-1 position of phosphatidylserine and 1-acyl-2-lysophosphatidylserine. This secreted protein hydrolyzes phosphatidylserine in liposomes. Three transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of heterotypic cell-cell adhesion (GO:0034116)7.45903669
2regulation of cytokine secretion involved in immune response (GO:0002739)6.72898227
3L-phenylalanine catabolic process (GO:0006559)6.09514238
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.09514238
5ketone body metabolic process (GO:1902224)6.07418869
6L-phenylalanine metabolic process (GO:0006558)5.89403910
7erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.89403910
8regulation of protein activation cascade (GO:2000257)5.83850982
9opsonization (GO:0008228)5.73368363
10regulation of complement activation (GO:0030449)5.66161102
11regulation of heterotypic cell-cell adhesion (GO:0034114)5.60408870
12negative regulation of lipase activity (GO:0060192)5.58882810
13aromatic amino acid family catabolic process (GO:0009074)5.51807457
14very-low-density lipoprotein particle assembly (GO:0034379)5.39188451
15triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.36230785
16complement activation, alternative pathway (GO:0006957)5.31101246
17negative regulation of fibrinolysis (GO:0051918)5.22562654
18negative regulation of protein activation cascade (GO:2000258)5.20899051
19kynurenine metabolic process (GO:0070189)5.01549560
20glyoxylate metabolic process (GO:0046487)5.01250433
21sulfur amino acid catabolic process (GO:0000098)5.00093698
22tryptophan catabolic process (GO:0006569)4.99463701
23indole-containing compound catabolic process (GO:0042436)4.99463701
24indolalkylamine catabolic process (GO:0046218)4.99463701
25protein carboxylation (GO:0018214)4.95192806
26peptidyl-glutamic acid carboxylation (GO:0017187)4.95192806
27regulation of fibrinolysis (GO:0051917)4.91269237
28negative regulation of complement activation (GO:0045916)4.82532462
29high-density lipoprotein particle remodeling (GO:0034375)4.74177986
30urea cycle (GO:0000050)4.73456553
31urea metabolic process (GO:0019627)4.73456553
32tryptophan metabolic process (GO:0006568)4.67145723
33cysteine metabolic process (GO:0006534)4.66471919
34positive regulation of respiratory burst (GO:0060267)4.65495737
35bile acid biosynthetic process (GO:0006699)4.63577213
36alpha-linolenic acid metabolic process (GO:0036109)4.54480436
37homocysteine metabolic process (GO:0050667)4.43761878
38melanin metabolic process (GO:0006582)4.40056572
39melanin biosynthetic process (GO:0042438)4.37577263
40nitrogen cycle metabolic process (GO:0071941)4.35655081
41serine family amino acid catabolic process (GO:0009071)4.33233958
42plasma lipoprotein particle clearance (GO:0034381)4.32792440
43reverse cholesterol transport (GO:0043691)4.32239239
44regulation of lipoprotein metabolic process (GO:0050746)4.28462670
45fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.27672636
46fibrinolysis (GO:0042730)4.19098304
47regulation of cholesterol esterification (GO:0010872)4.15405991
48regulation of triglyceride catabolic process (GO:0010896)4.12728775
49plasma lipoprotein particle remodeling (GO:0034369)4.08955564
50protein-lipid complex remodeling (GO:0034368)4.08955564
51macromolecular complex remodeling (GO:0034367)4.08955564
52protein-lipid complex subunit organization (GO:0071825)4.07818777
53lysine metabolic process (GO:0006553)4.04103552
54lysine catabolic process (GO:0006554)4.04103552
55bile acid metabolic process (GO:0008206)4.03126989
56acylglycerol homeostasis (GO:0055090)4.00672598
57triglyceride homeostasis (GO:0070328)4.00672598
58phospholipid efflux (GO:0033700)4.00163475
59negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)3.94818721
60amino-acid betaine metabolic process (GO:0006577)3.91926420
61aromatic amino acid family metabolic process (GO:0009072)3.91547129
62tyrosine metabolic process (GO:0006570)3.79559397
63alpha-amino acid catabolic process (GO:1901606)3.79282572
64bile acid and bile salt transport (GO:0015721)3.79224419
65acute-phase response (GO:0006953)3.78272952
66positive regulation of steroid metabolic process (GO:0045940)3.77354440
67secondary metabolite biosynthetic process (GO:0044550)3.75400852
68complement activation (GO:0006956)3.74069217
69cholesterol efflux (GO:0033344)3.70985531
70complement activation, classical pathway (GO:0006958)3.70571294
71cellular modified amino acid catabolic process (GO:0042219)3.65377849
72negative regulation of sterol transport (GO:0032372)3.63744983
73negative regulation of cholesterol transport (GO:0032375)3.63744983
74phospholipid homeostasis (GO:0055091)3.62984191
75protein activation cascade (GO:0072376)3.60805902
76blood coagulation, intrinsic pathway (GO:0007597)3.57335000
77cellular amino acid catabolic process (GO:0009063)3.57225627
78positive regulation of substrate adhesion-dependent cell spreading (GO:1900026)3.56904733
79cellular glucuronidation (GO:0052695)3.55207658
80cholesterol transport (GO:0030301)3.52753302
81sterol transport (GO:0015918)3.52753302
82plasma lipoprotein particle assembly (GO:0034377)3.49761729
83cellular ketone body metabolic process (GO:0046950)3.48310129
84aldehyde catabolic process (GO:0046185)3.47909034
85regulation of humoral immune response (GO:0002920)3.44875393
86benzene-containing compound metabolic process (GO:0042537)3.44359651
87glycine metabolic process (GO:0006544)3.44230051
88imidazole-containing compound metabolic process (GO:0052803)3.44056251
89arginine metabolic process (GO:0006525)3.42384876
90indolalkylamine metabolic process (GO:0006586)3.39918345
91regulation of plasminogen activation (GO:0010755)3.36660490
92lipoprotein metabolic process (GO:0042157)3.36435436
93dicarboxylic acid biosynthetic process (GO:0043650)3.35040426
94coenzyme catabolic process (GO:0009109)3.33275394
95amine catabolic process (GO:0009310)3.33115330
96cellular biogenic amine catabolic process (GO:0042402)3.33115330
97positive regulation of lipid catabolic process (GO:0050996)3.32293750
98serine family amino acid metabolic process (GO:0009069)3.31212281
99glutamate metabolic process (GO:0006536)3.31105649
100cholesterol homeostasis (GO:0042632)3.30379843
101protein-lipid complex assembly (GO:0065005)3.29939678
102positive regulation of Rho protein signal transduction (GO:0035025)3.29541498
1032-oxoglutarate metabolic process (GO:0006103)3.27744652
104low-density lipoprotein particle remodeling (GO:0034374)3.27734046
105epoxygenase P450 pathway (GO:0019373)3.27719386
106axon regeneration (GO:0031103)3.27299053
107sterol homeostasis (GO:0055092)3.26014128
108positive regulation of triglyceride lipase activity (GO:0061365)3.25584326
109positive regulation of lipoprotein lipase activity (GO:0051006)3.25584326
110phenylpropanoid metabolic process (GO:0009698)3.23925137
111uronic acid metabolic process (GO:0006063)3.23588417
112glucuronate metabolic process (GO:0019585)3.23588417
113regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.23402233
114ethanol oxidation (GO:0006069)3.23112440
115negative regulation of endothelial cell apoptotic process (GO:2000352)3.22495324
116positive regulation of blood coagulation (GO:0030194)3.21048394
117positive regulation of hemostasis (GO:1900048)3.21048394
118acetyl-CoA metabolic process (GO:0006084)3.20686897
119negative regulation of humoral immune response (GO:0002921)3.20052432
120plasma lipoprotein particle organization (GO:0071827)3.17165128
121positive regulation of macrophage cytokine production (GO:0060907)3.14703753
122carboxylic acid catabolic process (GO:0046395)3.14558562
123organic acid catabolic process (GO:0016054)3.14558562
124COPII vesicle coating (GO:0048208)3.12183221
125Golgi transport vesicle coating (GO:0048200)3.12124851
126COPI coating of Golgi vesicle (GO:0048205)3.12124851
127regulation of cholesterol transport (GO:0032374)3.08682045
128regulation of sterol transport (GO:0032371)3.08682045
129negative regulation of interleukin-1 beta production (GO:0032691)3.03975455
130valine metabolic process (GO:0006573)2.92869632
131retinal metabolic process (GO:0042574)2.91671710
132xenobiotic catabolic process (GO:0042178)2.87258250
133regulation of lipoprotein particle clearance (GO:0010984)2.83384247
134branched-chain amino acid catabolic process (GO:0009083)2.80096296
135drug catabolic process (GO:0042737)2.77622681
136omega-hydroxylase P450 pathway (GO:0097267)2.76105829
137regulation of substrate adhesion-dependent cell spreading (GO:1900024)2.75418674
138regulation of digestive system process (GO:0044058)2.73373143
139negative regulation of cytokine production involved in immune response (GO:0002719)2.71372727
140positive regulation of humoral immune response (GO:0002922)2.68180100
141short-chain fatty acid metabolic process (GO:0046459)2.68149050
142beta-amyloid metabolic process (GO:0050435)2.66963409
143retinol metabolic process (GO:0042572)2.66175531
144cholesterol biosynthetic process (GO:0006695)2.64746115
145negative regulation of blood coagulation (GO:0030195)2.64423927
146negative regulation of hemostasis (GO:1900047)2.64423927
147intestinal cholesterol absorption (GO:0030299)2.63242388
148exogenous drug catabolic process (GO:0042738)2.62045810

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse9.91070591
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse7.31603475
3RXR_22158963_ChIP-Seq_LIVER_Mouse6.97697851
4PPARA_22158963_ChIP-Seq_LIVER_Mouse5.98339244
5LXR_22158963_ChIP-Seq_LIVER_Mouse5.50677059
6* EGR1_23403033_ChIP-Seq_LIVER_Mouse5.47021154
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.23078365
8FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.25766534
9CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.09994682
10NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.38738798
11CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.99202583
12CLOCK_20551151_ChIP-Seq_293T_Human2.53038055
13RARG_19884340_ChIP-ChIP_MEFs_Mouse2.33902188
14TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.22424368
15IRF8_22096565_ChIP-ChIP_GC-B_Human2.14889100
16IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.98353717
17IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.97294727
18BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.97130048
19RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.94172751
20TRIM28_21343339_ChIP-Seq_HEK293_Human1.93657608
21THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.83056116
22PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.79227416
23ESR1_15608294_ChIP-ChIP_MCF-7_Human1.68241856
24TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.67382426
25VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.64332824
26HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.61329652
27STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.60363399
28STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.58452638
29FOXA1_25552417_ChIP-Seq_VCAP_Human1.55705391
30TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.55090970
31E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.46542156
32DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.44455091
33CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.41836339
34IRF8_21731497_ChIP-ChIP_J774_Mouse1.41190490
35* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.40275829
36FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.40047219
37ESR2_21235772_ChIP-Seq_MCF-7_Human1.39445086
38NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.38827837
39FOXA2_19822575_ChIP-Seq_HepG2_Human1.36840384
40ESR1_21235772_ChIP-Seq_MCF-7_Human1.36329317
41ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.35393315
42TP63_17297297_ChIP-ChIP_HaCaT_Human1.23533742
43STAT3_1855785_ChIP-Seq_MESCs_Mouse1.22828552
44NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.21527870
45Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.21118329
46GATA1_22025678_ChIP-Seq_K562_Human1.21088507
47NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.17612130
48HNF4A_19822575_ChIP-Seq_HepG2_Human1.16425207
49CDX2_20551321_ChIP-Seq_CACO-2_Human1.14921379
50* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.09361212
51SALL4_18804426_ChIP-ChIP_XEN_Mouse1.06980803
52* RXRA_24833708_ChIP-Seq_LIVER_Mouse1.06422105
53ZNF263_19887448_ChIP-Seq_K562_Human1.05866255
54TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.03890940
55PPAR_26484153_Chip-Seq_NCI-H1993_Human1.03765872
56E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.02981464
57FOXO3_23340844_ChIP-Seq_DLD1_Human1.02326211
58NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.01524362
59TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.00080411
60GATA2_21666600_ChIP-Seq_HMVEC_Human0.99070445
61NRF2_20460467_ChIP-Seq_MEFs_Mouse0.97701645
62NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.97701645
63SOX2_27498859_Chip-Seq_STOMACH_Mouse0.97141801
64ERG_20517297_ChIP-Seq_VCAP_Human0.95007587
65MITF_21258399_ChIP-Seq_MELANOMA_Human0.94126918
66PIAS1_25552417_ChIP-Seq_VCAP_Human0.94053170
67ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.93676587
68SOX2_20726797_ChIP-Seq_SW620_Human0.92158865
69HTT_18923047_ChIP-ChIP_STHdh_Human0.91857279
70ELF1_20517297_ChIP-Seq_JURKAT_Human0.90709146
71GATA4_25053715_ChIP-Seq_YYC3_Human0.89952589
72STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.89617563
73PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.88513328
74STAT4_19710469_ChIP-ChIP_TH1__Mouse0.87990955
75IRF8_27001747_Chip-Seq_BMDM_Mouse0.87273057
76SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.87084327
77LXR_22292898_ChIP-Seq_THP-1_Human0.87001777
78SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.86502391
79GATA6_25053715_ChIP-Seq_YYC3_Human0.83253111
80RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.82718082
81TBX20_22080862_ChIP-Seq_HEART_Mouse0.82499643
82TBX20_22328084_ChIP-Seq_HEART_Mouse0.82499643
83PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.81572494
84PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.79503774
85NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.79341696
86ELK3_25401928_ChIP-Seq_HUVEC_Human0.74892643
87CJUN_26792858_Chip-Seq_BT549_Human0.74512289
88AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.74274968
89HIF1A_21447827_ChIP-Seq_MCF-7_Human0.74042728
90PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.73400714
91RACK7_27058665_Chip-Seq_MCF-7_Human0.72567498
92SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.72496737
93* RARA_24833708_ChIP-Seq_LIVER_Mouse0.72337450
94TCF3_18692474_ChIP-Seq_MEFs_Mouse0.71904792
95NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.71493449
96GATA1_19941827_ChIP-Seq_MEL_Mouse0.71446233
97PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.70354100
98POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.70342574
99CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.69606806
100* GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.69474875
101ESR1_20079471_ChIP-ChIP_T-47D_Human0.68299168
102STAT1_20625510_ChIP-Seq_HELA_Human0.67943321
103FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.66768120
104RARB_24833708_ChIP-Seq_LIVER_Mouse0.66338521
105* CSB_26484114_Chip-Seq_FIBROBLAST_Human0.66141271
106TFEB_21752829_ChIP-Seq_HELA_Human0.65986134
107SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.64987160
108RAD21_21589869_ChIP-Seq_MESCs_Mouse0.64949912
109AUTS2_25519132_ChIP-Seq_293T-REX_Human0.64154593
110TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.63832076
111SRF_21415370_ChIP-Seq_HL-1_Mouse0.63584484
112FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.63549387
113JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.63439502
114SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.63386375
115SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.63374583
116BRD4_27068464_Chip-Seq_AML-cells_Mouse0.63044165
117GATA3_24758297_ChIP-Seq_MCF-7_Human0.62901118
118TBX5_21415370_ChIP-Seq_HL-1_Mouse0.62826968
119GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.62826332
120PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.62512443
121BCOR_27268052_Chip-Seq_Bcells_Human0.62445939
122PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.61836968
123LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.61352476
124LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.61169941
125MYB_21317192_ChIP-Seq_ERMYB_Mouse0.60910875
126NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.60687681
127SMAD3_21741376_ChIP-Seq_HESCs_Human0.60369636
128GATA3_21867929_ChIP-Seq_CD8_Mouse0.60151944
129EGR1_19032775_ChIP-ChIP_M12_Human0.59647857
130* AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.58768843
131P63_26484246_Chip-Seq_KERATINOCYTES_Human0.58553014
132* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.58159893
133PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.57891844
134CEBPB_22108803_ChIP-Seq_LS180_Human0.57753211
135SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.57698330
136BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.57314304
137SOX2_18692474_ChIP-Seq_MEFs_Mouse0.56884810
138ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.56552239
139KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.56230764
140CDX2_19796622_ChIP-Seq_MESCs_Mouse0.55262585
141ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.55151935
142ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.54898370
143OCT4_18692474_ChIP-Seq_MEFs_Mouse0.54852619
144JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.54384707
145CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.53190172
146NFIB_24661679_ChIP-Seq_LUNG_Mouse0.52923102

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.25898981
2MP0005360_urolithiasis5.97288464
3MP0005085_abnormal_gallbladder_physiolo5.03126582
4MP0005365_abnormal_bile_salt4.80922725
5MP0000372_irregular_coat_pigmentation4.11606864
6MP0008875_abnormal_xenobiotic_pharmacok3.98919730
7MP0005171_absent_coat_pigmentation3.75638138
8MP0003252_abnormal_bile_duct3.47370561
9MP0002254_reproductive_system_inflammat3.32363768
10MP0008438_abnormal_cutaneous_collagen3.29435571
11MP0003806_abnormal_nucleotide_metabolis3.25833935
12MP0010329_abnormal_lipoprotein_level3.08876504
13MP0005075_abnormal_melanosome_morpholog3.00101536
14MP0009840_abnormal_foam_cell2.83699185
15MP0003195_calcinosis2.66831453
16MP0003191_abnormal_cellular_cholesterol2.57172949
17MP0005332_abnormal_amino_acid2.41214093
18MP0002138_abnormal_hepatobiliary_system2.29465252
19MP0005645_abnormal_hypothalamus_physiol2.26557482
20MP0005083_abnormal_biliary_tract2.21936421
21MP0002166_altered_tumor_susceptibility2.05928243
22MP0000015_abnormal_ear_pigmentation2.05251758
23MP0004381_abnormal_hair_follicle2.03121014
24MP0004019_abnormal_vitamin_homeostasis1.99391437
25MP0001666_abnormal_nutrient_absorption1.97683508
26MP0003705_abnormal_hypodermis_morpholog1.96031698
27MP0000609_abnormal_liver_physiology1.93189681
28MP0003303_peritoneal_inflammation1.87438098
29MP0000371_diluted_coat_color1.78692450
30MP0002118_abnormal_lipid_homeostasis1.78077422
31MP0002090_abnormal_vision1.75117802
32MP0005257_abnormal_intraocular_pressure1.68405609
33MP0005319_abnormal_enzyme/_coenzyme1.67709170
34MP0005275_abnormal_skin_tensile1.64227214
35MP0000604_amyloidosis1.56246995
36MP0002909_abnormal_adrenal_gland1.53417820
37MP0005220_abnormal_exocrine_pancreas1.52937505
38MP0002822_catalepsy1.51657722
39MP0009764_decreased_sensitivity_to1.45182685
40MP0001324_abnormal_eye_pigmentation1.44483826
41MP0001790_abnormal_immune_system1.42790798
42MP0005387_immune_system_phenotype1.42790798
43MP0009643_abnormal_urine_homeostasis1.41941727
44MP0005584_abnormal_enzyme/coenzyme_acti1.40298245
45MP0005310_abnormal_salivary_gland1.36267694
46MP0003186_abnormal_redox_activity1.35578509
47MP0003136_yellow_coat_color1.35009753
48MP0005671_abnormal_response_to1.32285826
49MP0002837_dystrophic_cardiac_calcinosis1.31808867
50MP0001944_abnormal_pancreas_morphology1.29155326
51MP0002006_tumorigenesis1.27988731
52MP0010368_abnormal_lymphatic_system1.26185592
53MP0005379_endocrine/exocrine_gland_phen1.25451950
54MP0003279_aneurysm1.19774377
55MP0003879_abnormal_hair_cell1.17781098
56MP0005670_abnormal_white_adipose1.16973395
57MP0001764_abnormal_homeostasis1.14858322
58MP0008469_abnormal_protein_level1.11904131
59MP0004883_abnormal_blood_vessel1.11766682
60MP0003868_abnormal_feces_composition1.11633362
61MP0009763_increased_sensitivity_to1.11223742
62MP0000598_abnormal_liver_morphology1.09529112
63MP0010386_abnormal_urinary_bladder1.08664899
64MP0005164_abnormal_response_to1.07739125
65MP0000685_abnormal_immune_system1.07681995
66MP0006082_CNS_inflammation1.06147993
67MP0000920_abnormal_myelination1.04985429
68MP0003045_fibrosis1.01789854
69MP0005636_abnormal_mineral_homeostasis1.00873140
70MP0001800_abnormal_humoral_immune0.99204672
71MP0003172_abnormal_lysosome_physiology0.97803092
72MP0001756_abnormal_urination0.97396256
73MP0003656_abnormal_erythrocyte_physiolo0.97054828
74MP0003011_delayed_dark_adaptation0.96826989
75MP0009785_altered_susceptibility_to0.96766685
76MP0002095_abnormal_skin_pigmentation0.96241284
77MP0003566_abnormal_cell_adhesion0.95662003
78MP0003436_decreased_susceptibility_to0.95589661
79MP0003283_abnormal_digestive_organ0.95075838
80MP0004130_abnormal_muscle_cell0.95055764
81MP0005647_abnormal_sex_gland0.94901905
82MP0002163_abnormal_gland_morphology0.94638636
83MP0008961_abnormal_basal_metabolism0.94243906
84MP0005503_abnormal_tendon_morphology0.93796939
85MP0005023_abnormal_wound_healing0.93713951
86MP0001881_abnormal_mammary_gland0.91081840
87MP0002075_abnormal_coat/hair_pigmentati0.90069938
88MP0002693_abnormal_pancreas_physiology0.89855977
89MP0005451_abnormal_body_composition0.87539482
90MP0002938_white_spotting0.86771619
91MP0003724_increased_susceptibility_to0.86160067
92MP0005376_homeostasis/metabolism_phenot0.85715005
93MP0004272_abnormal_basement_membrane0.83835494
94MP0001958_emphysema0.83522531
95MP0001542_abnormal_bone_strength0.83175527
96MP0009642_abnormal_blood_homeostasis0.82620338
97MP0005058_abnormal_lysosome_morphology0.82426377
98MP0002060_abnormal_skin_morphology0.82332191
99MP0004510_myositis0.81324985
100MP0002876_abnormal_thyroid_physiology0.81244849
101MP0002971_abnormal_brown_adipose0.80826728
102MP0003633_abnormal_nervous_system0.79969479
103MP0000569_abnormal_digit_pigmentation0.79421670
104MP0000249_abnormal_blood_vessel0.78982495
105MP0001661_extended_life_span0.78898357
106MP0005367_renal/urinary_system_phenotyp0.78551553
107MP0000516_abnormal_urinary_system0.78551553
108MP0002136_abnormal_kidney_physiology0.77585107
109MP0005167_abnormal_blood-brain_barrier0.75429995
110MP0005000_abnormal_immune_tolerance0.74746508
111MP0010234_abnormal_vibrissa_follicle0.74662680
112MP0002168_other_aberrant_phenotype0.74614513
113MP0000343_altered_response_to0.73425928
114MP0009697_abnormal_copulation0.72035859
115MP0002269_muscular_atrophy0.71165679
116MP0005408_hypopigmentation0.70892270
117MP0005623_abnormal_meninges_morphology0.70482053
118MP0002723_abnormal_immune_serum0.70454183
119MP0001835_abnormal_antigen_presentation0.70324217
120MP0001533_abnormal_skeleton_physiology0.68704147
121MP0001348_abnormal_lacrimal_gland0.68299229
122MP0002452_abnormal_antigen_presenting0.68234184
123MP0001186_pigmentation_phenotype0.68028034
124MP0009046_muscle_twitch0.65962481
125MP0002295_abnormal_pulmonary_circulatio0.65844155
126MP0005395_other_phenotype0.65458585
127MP0005166_decreased_susceptibility_to0.65284093
128MP0000767_abnormal_smooth_muscle0.65244593
129MP0003183_abnormal_peptide_metabolism0.64985355
130MP0006054_spinal_hemorrhage0.64743220
131MP0005464_abnormal_platelet_physiology0.64225887
132MP0005666_abnormal_adipose_tissue0.63696512
133MP0003953_abnormal_hormone_level0.63677294
134MP0005551_abnormal_eye_electrophysiolog0.62517152
135MP0009765_abnormal_xenobiotic_induced0.62426179
136MP0001845_abnormal_inflammatory_respons0.62386341
137MP0005334_abnormal_fat_pad0.62301879
138MP0005253_abnormal_eye_physiology0.62114060
139MP0002078_abnormal_glucose_homeostasis0.61057799
140MP0000537_abnormal_urethra_morphology0.58890485
141MP0001243_abnormal_dermal_layer0.57037944
142MP0000858_altered_metastatic_potential0.56572673
143MP0005330_cardiomyopathy0.56083413
144MP0000639_abnormal_adrenal_gland0.55425744
145MP0002419_abnormal_innate_immunity0.54949057
146MP0003075_altered_response_to0.54935692
147MP0009115_abnormal_fat_cell0.54336825
148MP0005025_abnormal_response_to0.54083192
149MP0005084_abnormal_gallbladder_morpholo0.53994223
150MP0001915_intracranial_hemorrhage0.53918721
151MP0003453_abnormal_keratinocyte_physiol0.52486257
152MP0003690_abnormal_glial_cell0.52402094
153MP0003329_amyloid_beta_deposits0.52156386
154MP0008775_abnormal_heart_ventricle0.51400755
155MP0003448_altered_tumor_morphology0.50482076

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)6.65077734
2Intrahepatic cholestasis (HP:0001406)5.89955334
3Abnormality of aromatic amino acid family metabolism (HP:0004338)5.65154159
4Abnormality of monocarboxylic acid metabolism (HP:0010996)5.43297641
5Xanthomatosis (HP:0000991)5.29869980
6Prolonged partial thromboplastin time (HP:0003645)5.15166184
7Complement deficiency (HP:0004431)5.13638693
8Systemic lupus erythematosus (HP:0002725)4.77130944
9Hypobetalipoproteinemia (HP:0003563)4.76568210
10Gastrointestinal stroma tumor (HP:0100723)4.64723868
11Hyperlipoproteinemia (HP:0010980)4.44795256
12Abnormality of glutamine family amino acid metabolism (HP:0010902)4.29884729
13Joint hemorrhage (HP:0005261)4.17710994
14Abnormality of the common coagulation pathway (HP:0010990)4.11645533
15Hypolipoproteinemia (HP:0010981)3.99790737
16Hyperammonemia (HP:0001987)3.87095352
17Hypoalphalipoproteinemia (HP:0003233)3.86665175
18Abnormality of complement system (HP:0005339)3.86184063
19Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.68896319
20Joint swelling (HP:0001386)3.62095230
21Epidermoid cyst (HP:0200040)3.59482518
22Spontaneous abortion (HP:0005268)3.53588400
23Myocardial infarction (HP:0001658)3.48891919
24Ketosis (HP:0001946)3.47793276
25Hyperglycinuria (HP:0003108)3.44128913
26Abnormality of sulfur amino acid metabolism (HP:0004339)3.41713399
27Hypoglycemic coma (HP:0001325)3.34403215
28Blue irides (HP:0000635)3.29923751
29Abnormality of the intrinsic pathway (HP:0010989)3.29707803
30Hyperglycinemia (HP:0002154)3.28669961
31Abnormality of aspartate family amino acid metabolism (HP:0010899)3.25744773
32Fat malabsorption (HP:0002630)3.25581728
33Abnormality of methionine metabolism (HP:0010901)3.23477656
34Retinal atrophy (HP:0001105)3.21302222
35Abnormality of serine family amino acid metabolism (HP:0010894)3.18103202
36Abnormality of glycine metabolism (HP:0010895)3.18103202
37Aplasia/Hypoplasia of the fovea (HP:0008060)3.06416852
38Hypoplasia of the fovea (HP:0007750)3.06416852
39White forelock (HP:0002211)3.06150878
40Ocular albinism (HP:0001107)3.02438204
41Abnormality of fatty-acid metabolism (HP:0004359)3.02253281
42Hydroxyprolinuria (HP:0003080)3.00461306
43Abnormality of proline metabolism (HP:0010907)3.00461306
44Vacuolated lymphocytes (HP:0001922)2.96651677
45Hypercholesterolemia (HP:0003124)2.94841561
46Conjugated hyperbilirubinemia (HP:0002908)2.88873170
47Patchy hypopigmentation of hair (HP:0011365)2.88779264
48Skin nodule (HP:0200036)2.88530414
49Recurrent sinusitis (HP:0011108)2.86224187
50Glomerulonephritis (HP:0000099)2.85182536
51Abnormality of the fovea (HP:0000493)2.84120362
52Abnormality of purine metabolism (HP:0004352)2.83741104
53Gingival bleeding (HP:0000225)2.83073352
54Abnormality of nucleobase metabolism (HP:0010932)2.82872718
55Abnormality of pyrimidine metabolism (HP:0004353)2.81135945
56Purpura (HP:0000979)2.77127916
57Nuclear cataract (HP:0100018)2.75395728
58Iris hypopigmentation (HP:0007730)2.69875483
59Hyperbilirubinemia (HP:0002904)2.67873590
60Malnutrition (HP:0004395)2.65480022
61Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.64240920
62Esophageal varix (HP:0002040)2.63829233
63Abnormal cartilage morphology (HP:0002763)2.62431610
64Hepatocellular carcinoma (HP:0001402)2.61502657
65Emphysema (HP:0002097)2.60383140
66Nephritis (HP:0000123)2.57709001
67Recurrent bronchitis (HP:0002837)2.56300513
68Mitral stenosis (HP:0001718)2.55116838
69Aplasia/Hypoplasia of the macula (HP:0008059)2.54815144
70Ketoacidosis (HP:0001993)2.53248871
71Premature rupture of membranes (HP:0001788)2.53248589
72Petechiae (HP:0000967)2.49915599
73Amyloidosis (HP:0011034)2.46759063
74Spastic diplegia (HP:0001264)2.42704481
75IgA deficiency (HP:0002720)2.40182227
76Lower limb hyperreflexia (HP:0002395)2.37646007
77Hemorrhage of the eye (HP:0011885)2.37548267
78Gout (HP:0001997)2.36399339
79Aplasia/Hypoplasia affecting the retina (HP:0008061)2.35087177
80Steatorrhea (HP:0002570)2.34657761
81Cardiovascular calcification (HP:0011915)2.34638092
82Hyperinsulinemic hypoglycemia (HP:0000825)2.34616512
83Abnormality of the pancreatic islet cells (HP:0006476)2.33715020
84Abnormality of endocrine pancreas physiology (HP:0012093)2.33715020
85Albinism (HP:0001022)2.32088110
86Abnormal pupillary function (HP:0007686)2.30570683
87Vascular calcification (HP:0004934)2.29292642
88Peritonitis (HP:0002586)2.27609952
89Increased CSF protein (HP:0002922)2.26642306
90Right ventricular cardiomyopathy (HP:0011663)2.25293541
91Abnormality of serum amino acid levels (HP:0003112)2.23925503
92Generalized hypopigmentation (HP:0007513)2.18994962
93Osteolytic defects of the phalanges of the hand (HP:0009771)2.18373253
94Osteolytic defects of the hand bones (HP:0009699)2.18373253
95Menorrhagia (HP:0000132)2.17142441
96Cholelithiasis (HP:0001081)2.16968558
97Recurrent gram-negative bacterial infections (HP:0005420)2.15702967
98Aortic dissection (HP:0002647)2.14379918
99Abnormal gallbladder morphology (HP:0012437)2.14229478
100Pancreatitis (HP:0001733)2.14181097
101Hypochromic microcytic anemia (HP:0004840)2.13514875
102Peripheral hypomyelination (HP:0007182)2.11924911
103Spondylolisthesis (HP:0003302)2.11621632
104Abnormal delivery (HP:0001787)2.11234056
105Metabolic acidosis (HP:0001942)2.09470776
106Delayed CNS myelination (HP:0002188)2.09015571
107J-shaped sella turcica (HP:0002680)2.05634166
108Bilateral sensorineural hearing impairment (HP:0008619)2.05254802
109Vasculitis (HP:0002633)2.05240267
110Neonatal onset (HP:0003623)2.05042393
111Lymphopenia (HP:0001888)2.04856711
112Spastic paraparesis (HP:0002313)2.04520467
113Thrombophlebitis (HP:0004418)2.04518150
114Late onset (HP:0003584)2.02786062
115Abnormality of dicarboxylic acid metabolism (HP:0010995)2.02019817
116Dicarboxylic aciduria (HP:0003215)2.02019817
117Lethargy (HP:0001254)1.99577556
118Abnormality of iron homeostasis (HP:0011031)1.99275077
119Stroke (HP:0001297)1.98812387
120Hypopigmentation of the fundus (HP:0007894)1.98612298
121Epistaxis (HP:0000421)1.97163980
122Nausea (HP:0002018)1.96427695
123Abnormal pancreas size (HP:0012094)1.95634680
124Irritability (HP:0000737)1.95395320
125Restrictive lung disease (HP:0002091)1.94843573
126Alkalosis (HP:0001948)1.94292657
127Abnormality of transition element cation homeostasis (HP:0011030)1.94259486
128Protrusio acetabuli (HP:0003179)1.92700843
129Paraparesis (HP:0002385)1.91853652
130Abnormality of cells of the lymphoid lineage (HP:0012140)1.89334181
131Increased mean platelet volume (HP:0011877)1.88917811
132Hypoglycemic seizures (HP:0002173)1.88250180
133Vomiting (HP:0002013)1.88176105
134Abnormality of vitamin metabolism (HP:0100508)1.88113931
135Tongue fasciculations (HP:0001308)1.87333816
136Polycythemia (HP:0001901)1.85233854
137Increased purine levels (HP:0004368)1.84615942
138Hyperuricemia (HP:0002149)1.84615942
139Generalized aminoaciduria (HP:0002909)1.83632949
140Gastrointestinal infarctions (HP:0005244)1.82672638
141Progressive neurologic deterioration (HP:0002344)1.81776749
142Dysostosis multiplex (HP:0000943)1.81108759
143Tetraparesis (HP:0002273)1.80357909
144Sensorimotor neuropathy (HP:0007141)1.79438430
145Prolonged neonatal jaundice (HP:0006579)1.79240491
146Stridor (HP:0010307)1.79071460
147Impaired proprioception (HP:0010831)1.78292167
148Postural tremor (HP:0002174)1.77307804
149Agammaglobulinemia (HP:0004432)1.77152742
150Aortic aneurysm (HP:0004942)1.76861080
151Elevated hepatic transaminases (HP:0002910)1.75960436
152Heterochromia iridis (HP:0001100)1.75239401
153Polyneuropathy (HP:0001271)1.75189015
154Recurrent pneumonia (HP:0006532)1.73947923
155Generalized hypopigmentation of hair (HP:0011358)1.71255071
156Abnormal tarsal ossification (HP:0008369)1.69387146
157Chronic diarrhea (HP:0002028)1.67925133
158Symptomatic seizures (HP:0011145)1.65386265
159Hyperglycemia (HP:0003074)1.65185315
160Progressive sensorineural hearing impairment (HP:0000408)1.64982720
161Upper limb muscle weakness (HP:0003484)1.64499722

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK4.74294320
2ERN14.32802555
3FGFR43.56479226
4TRIB33.18564005
5TGFBR22.81891663
6SIK12.81459677
7TAOK12.73038331
8RIPK42.67993570
9MAP4K12.55286394
10TNK22.48446852
11ARAF2.48071599
12EIF2AK32.41209101
13MST1R2.40389201
14TYK22.37860386
15EEF2K2.35704416
16LMTK22.30066808
17MAP3K142.27834215
18TTN2.21539703
19MYLK2.20672125
20PIK3CG2.19394584
21CAMK1G2.11900743
22NEK91.90091276
23TAOK31.82844651
24PKN21.74679678
25PDGFRA1.72491468
26EPHB11.63655651
27IRAK41.61705469
28ERBB41.60573041
29TBK11.59927420
30PRKCI1.59197624
31FLT31.47368401
32LATS11.47080038
33JAK11.43797189
34ABL21.42710259
35INSRR1.42569754
36NME21.41459529
37MAPKAPK31.39767087
38PTK61.39267385
39MET1.34302712
40GRK11.31767708
41EPHA31.31121661
42KDR1.30286386
43DDR21.28335035
44IRAK31.28137852
45PDK11.26056999
46PRPF4B1.23858225
47JAK31.22845603
48PRKD21.22556930
49PHKG11.19094215
50PHKG21.19094215
51BMX1.15482788
52SMG11.13052144
53MAPK111.06501083
54TLK11.05513846
55FGFR31.02962917
56NLK1.00727715
57MAP3K21.00525742
58MAP3K101.00330286
59JAK20.98442769
60TIE10.97759329
61CSK0.97404319
62IKBKE0.96759233
63STK38L0.95858156
64RIPK10.93935901
65MAP3K70.87373335
66TRPM70.85407779
67PTK20.84334205
68MAP3K130.84152530
69MAP2K60.82801604
70SYK0.81073930
71PIM20.80729180
72DYRK1B0.80689195
73BLK0.79732530
74PRKAA20.79331542
75MAPK120.79233667
76BRAF0.79096911
77IKBKB0.78827891
78PDK20.78249511
79CSF1R0.76960248
80MAP3K30.74093850
81PASK0.73651842
82CHUK0.73317818
83LRRK20.71436849
84GSK3A0.70429869
85STK30.69739286
86CDK60.69077100
87KIT0.68791928
88RPS6KA50.68692655
89RAF10.67565564
90NTRK30.66303654
91MAP2K30.66099739
92VRK10.62476117
93FER0.61174986
94ACVR1B0.60593513
95PBK0.60073628
96FRK0.59013722
97EPHA20.58992744
98CDC42BPA0.57229039
99PRKCQ0.53789817
100MARK30.53360898
101LYN0.51930594
102PRKCH0.51698103
103PAK20.51499337
104PDPK10.50615895
105DAPK30.50562633
106FGFR20.49870499
107PRKACG0.49866121
108MAP3K110.49822999
109MAPK40.49679029
110AKT20.49264529
111EPHB20.48462424
112PAK40.47978703
113IRAK10.46966121
114WNK30.44908787
115MAP2K10.44896686
116PINK10.44504165
117PRKAA10.44272900
118MTOR0.43790764
119IRAK20.42509989
120DAPK10.42281542
121MAPK70.41851084
122TESK20.41748454
123MAP2K40.40888533
124PDK40.40877596
125PDK30.40877596
126PRKCG0.40567472
127CDK30.40415507
128LATS20.40222905
129PAK30.40182733
130CAMK2G0.39007668
131HIPK20.38453658
132ABL10.37197512
133EGFR0.37012964
134DAPK20.36987939
135MAP2K20.36436472
136FGR0.35979306
137PRKCZ0.35862978
138IGF1R0.35335625
139PRKCE0.35011117
140PTK2B0.34594778
141ZAP700.33514616
142PIM10.33329791
143ZAK0.32378225
144CAMK1D0.32105811
145MAPKAPK50.31827245
146PKN10.30948122
147SGK2230.30902915
148SGK4940.30902915
149CSNK1A10.30504582
150MST40.30164818
151PRKD10.29101962
152EIF2AK10.28724322
153PRKCB0.28363210
154ROCK10.27272987
155AKT30.26558115
156RET0.26163283
157MAP3K50.26157276

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.99652960
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.73735380
3Nitrogen metabolism_Homo sapiens_hsa009103.69033282
4Complement and coagulation cascades_Homo sapiens_hsa046103.16445825
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.06051973
6Arginine biosynthesis_Homo sapiens_hsa002203.03340871
7Tryptophan metabolism_Homo sapiens_hsa003802.62059496
8Fatty acid degradation_Homo sapiens_hsa000712.43786077
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.43092838
10Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.34682126
11Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.34016875
12Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.30725197
13Staphylococcus aureus infection_Homo sapiens_hsa051502.27072982
14Pentose and glucuronate interconversions_Homo sapiens_hsa000402.24010093
15Caffeine metabolism_Homo sapiens_hsa002322.07596077
16Type I diabetes mellitus_Homo sapiens_hsa049402.05289197
17PPAR signaling pathway_Homo sapiens_hsa033202.03792091
18Histidine metabolism_Homo sapiens_hsa003401.90154463
19Systemic lupus erythematosus_Homo sapiens_hsa053221.89197867
20Peroxisome_Homo sapiens_hsa041461.88675313
21Propanoate metabolism_Homo sapiens_hsa006401.79068547
222-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.78458642
23Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.77950289
24Asthma_Homo sapiens_hsa053101.76462394
25Steroid hormone biosynthesis_Homo sapiens_hsa001401.74481592
26Fatty acid metabolism_Homo sapiens_hsa012121.74416970
27Butanoate metabolism_Homo sapiens_hsa006501.72867133
28Chemical carcinogenesis_Homo sapiens_hsa052041.71539328
29Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.68899594
30Phenylalanine metabolism_Homo sapiens_hsa003601.59424543
31Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.58347423
32beta-Alanine metabolism_Homo sapiens_hsa004101.57006885
33Drug metabolism - other enzymes_Homo sapiens_hsa009831.42439462
34Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.41999319
35Retinol metabolism_Homo sapiens_hsa008301.40288304
36Selenocompound metabolism_Homo sapiens_hsa004501.33784798
37Bile secretion_Homo sapiens_hsa049761.33459852
38Starch and sucrose metabolism_Homo sapiens_hsa005001.28555175
39Tyrosine metabolism_Homo sapiens_hsa003501.27430836
40Pyruvate metabolism_Homo sapiens_hsa006201.22507998
41Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.21856787
42Biosynthesis of amino acids_Homo sapiens_hsa012301.20098946
43Cyanoamino acid metabolism_Homo sapiens_hsa004601.16789417
44Carbon metabolism_Homo sapiens_hsa012001.16208463
45Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.13651198
46Cysteine and methionine metabolism_Homo sapiens_hsa002701.12483856
47Fat digestion and absorption_Homo sapiens_hsa049751.12108953
48Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.09278466
49Sulfur metabolism_Homo sapiens_hsa009201.09202361
50Arginine and proline metabolism_Homo sapiens_hsa003301.07168064
51ABC transporters_Homo sapiens_hsa020101.04889369
52Folate biosynthesis_Homo sapiens_hsa007901.02355601
53Fatty acid elongation_Homo sapiens_hsa000621.01021285
54Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.00424575
55Glutathione metabolism_Homo sapiens_hsa004800.90578629
56Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.87237618
57Steroid biosynthesis_Homo sapiens_hsa001000.87192709
58Vitamin digestion and absorption_Homo sapiens_hsa049770.81933107
59Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.76787362
60Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.76061770
61Pentose phosphate pathway_Homo sapiens_hsa000300.74635347
62Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.70657351
63Lysine degradation_Homo sapiens_hsa003100.69348214
64Glycosaminoglycan degradation_Homo sapiens_hsa005310.68284842
65Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.66525377
66Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.64612807
67Maturity onset diabetes of the young_Homo sapiens_hsa049500.64334338
68Primary immunodeficiency_Homo sapiens_hsa053400.64047165
69Sphingolipid metabolism_Homo sapiens_hsa006000.63884394
70Renin-angiotensin system_Homo sapiens_hsa046140.62220007
71Glycerolipid metabolism_Homo sapiens_hsa005610.61926872
72Sulfur relay system_Homo sapiens_hsa041220.61425398
73Fatty acid biosynthesis_Homo sapiens_hsa000610.55067454
74Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.53834386
75Vitamin B6 metabolism_Homo sapiens_hsa007500.53606790
76Prion diseases_Homo sapiens_hsa050200.53381995
77Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.52773214
78One carbon pool by folate_Homo sapiens_hsa006700.51356275
79Antigen processing and presentation_Homo sapiens_hsa046120.48891858
80Galactose metabolism_Homo sapiens_hsa000520.46802654
81Alcoholism_Homo sapiens_hsa050340.43793410
82Adipocytokine signaling pathway_Homo sapiens_hsa049200.41297715
83Graft-versus-host disease_Homo sapiens_hsa053320.40536306
84Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.37750142
85Allograft rejection_Homo sapiens_hsa053300.37138417
86Influenza A_Homo sapiens_hsa051640.36618134
87B cell receptor signaling pathway_Homo sapiens_hsa046620.36057678
88Metabolic pathways_Homo sapiens_hsa011000.34879553
89N-Glycan biosynthesis_Homo sapiens_hsa005100.34776006
90Vibrio cholerae infection_Homo sapiens_hsa051100.34558941
91Type II diabetes mellitus_Homo sapiens_hsa049300.34276611
92Insulin resistance_Homo sapiens_hsa049310.32455399
93Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.30662087
94Amoebiasis_Homo sapiens_hsa051460.30402976
95Fructose and mannose metabolism_Homo sapiens_hsa000510.29092894
96Protein export_Homo sapiens_hsa030600.28579911
97alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.27296703
98Pertussis_Homo sapiens_hsa051330.26459870
99Toll-like receptor signaling pathway_Homo sapiens_hsa046200.24468800
100Collecting duct acid secretion_Homo sapiens_hsa049660.24202488
101Lysosome_Homo sapiens_hsa041420.21396232
102ECM-receptor interaction_Homo sapiens_hsa045120.21100442
103Insulin secretion_Homo sapiens_hsa049110.20656349
104Herpes simplex infection_Homo sapiens_hsa051680.19937121
105Arachidonic acid metabolism_Homo sapiens_hsa005900.19705363
106Malaria_Homo sapiens_hsa051440.18656325
107Toxoplasmosis_Homo sapiens_hsa051450.16475244
108Linoleic acid metabolism_Homo sapiens_hsa005910.15571680
109Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.14547156
110Autoimmune thyroid disease_Homo sapiens_hsa053200.13039396
111Intestinal immune network for IgA production_Homo sapiens_hsa046720.10992971
112Legionellosis_Homo sapiens_hsa051340.09307818
113Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.08514402
114African trypanosomiasis_Homo sapiens_hsa051430.07657491
115NF-kappa B signaling pathway_Homo sapiens_hsa040640.06450030
116Other glycan degradation_Homo sapiens_hsa005110.06212200
117Viral myocarditis_Homo sapiens_hsa054160.04656946
118AMPK signaling pathway_Homo sapiens_hsa041520.02677064
119Rheumatoid arthritis_Homo sapiens_hsa053230.02316480
120RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.02066185
121Leishmaniasis_Homo sapiens_hsa051400.00085290
122Glucagon signaling pathway_Homo sapiens_hsa04922-0.0148210
123Glycerophospholipid metabolism_Homo sapiens_hsa00564-0.0034065

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