ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	8.20145649
2	ATP synthesis coupled proton transport (GO:0015986)	7.12476287
3	energy coupled proton transport, down electrochemical gradient (GO:0015985)	7.12476287
4	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	5.75924564
5	respiratory electron transport chain (GO:0022904)	5.60433840
6	chaperone-mediated protein transport (GO:0072321)	5.49415624
7	electron transport chain (GO:0022900)	5.48878577
8	regulation of mitochondrial translation (GO:0070129)	5.34196609
9	protein complex biogenesis (GO:0070271)	5.34068913
10	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	5.26015891
11	mitochondrial respiratory chain complex I assembly (GO:0032981)	5.26015891
12	NADH dehydrogenase complex assembly (GO:0010257)	5.26015891
13	establishment of protein localization to mitochondrial membrane (GO:0090151)	5.12408292
14	mitochondrial respiratory chain complex assembly (GO:0033108)	4.81953082
15	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	4.76873274
16	respiratory chain complex IV assembly (GO:0008535)	4.44603820
17	epithelial cilium movement (GO:0003351)	4.31365351
18	inner mitochondrial membrane organization (GO:0007007)	4.27408635
19	ribosomal small subunit biogenesis (GO:0042274)	4.27341406
20	transcription elongation from RNA polymerase III promoter (GO:0006385)	4.20605707
21	termination of RNA polymerase III transcription (GO:0006386)	4.20605707
22	translational termination (GO:0006415)	4.12418696
23	axonemal dynein complex assembly (GO:0070286)	4.01541769
24	behavioral response to cocaine (GO:0048148)	4.01468943
25	ATP biosynthetic process (GO:0006754)	3.98478798
26	viral transcription (GO:0019083)	3.97487591
27	folic acid metabolic process (GO:0046655)	3.94776169
28	cytochrome complex assembly (GO:0017004)	3.90772100
29	proteasome assembly (GO:0043248)	3.89972273
30	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.86680550
31	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.85997225
32	regulation of synapse structural plasticity (GO:0051823)	3.80612518
33	peristalsis (GO:0030432)	3.76918184
34	cilium movement (GO:0003341)	3.75778251
35	CENP-A containing nucleosome assembly (GO:0034080)	3.75732117
36	DNA replication checkpoint (GO:0000076)	3.69435030
37	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	3.65243975
38	maturation of SSU-rRNA (GO:0030490)	3.61960534
39	ribonucleoside triphosphate biosynthetic process (GO:0009201)	3.60697461
40	chromatin remodeling at centromere (GO:0031055)	3.59078035
41	cotranslational protein targeting to membrane (GO:0006613)	3.58152621
42	protein targeting to ER (GO:0045047)	3.56597772
43	nucleoside triphosphate biosynthetic process (GO:0009142)	3.51851389
44	protein localization to mitochondrion (GO:0070585)	3.49228554
45	striatum development (GO:0021756)	3.47552509
46	GTP biosynthetic process (GO:0006183)	3.46472245
47	protein targeting to mitochondrion (GO:0006626)	3.46319103
48	substrate-independent telencephalic tangential migration (GO:0021826)	3.46224870
49	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	3.46224870
50	spliceosomal snRNP assembly (GO:0000387)	3.46194894
51	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	3.45072012
52	ribosomal small subunit assembly (GO:0000028)	3.43088138
53	regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)	3.40760523
54	regulation of dopamine uptake involved in synaptic transmission (GO:0051584)	3.40760523
55	cilium or flagellum-dependent cell motility (GO:0001539)	3.40692237
56	establishment of protein localization to endoplasmic reticulum (GO:0072599)	3.35937665
57	protein localization to endoplasmic reticulum (GO:0070972)	3.32651258
58	establishment of protein localization to mitochondrion (GO:0072655)	3.32560826
59	hydrogen ion transmembrane transport (GO:1902600)	3.31743550
60	mitochondrial transport (GO:0006839)	3.27473783
61	translational elongation (GO:0006414)	3.24183169
62	cellular protein complex disassembly (GO:0043624)	3.23154340
63	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	3.21875702
64	negative regulation of ligase activity (GO:0051352)	3.21875702
65	translational initiation (GO:0006413)	3.21218464
66	UTP biosynthetic process (GO:0006228)	3.20620643
67	protein neddylation (GO:0045116)	3.18697483
68	positive regulation of mitochondrial calcium ion concentration (GO:0051561)	3.16895384
69	ribosomal large subunit biogenesis (GO:0042273)	3.15550427
70	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	3.14673002
71	response to inactivity (GO:0014854)	3.14005583
72	motile cilium assembly (GO:0044458)	3.10810545
73	G-protein coupled receptor internalization (GO:0002031)	3.10600869
74	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	3.08109020
75	establishment of integrated proviral latency (GO:0075713)	3.06375904
76	pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)	3.04762474
77	kinetochore assembly (GO:0051382)	3.04409505
78	pyrimidine nucleoside triphosphate metabolic process (GO:0009147)	3.03570575
79	viral life cycle (GO:0019058)	3.02286716
80	oxidative phosphorylation (GO:0006119)	3.01857887
81	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0	2.99058441
82	CTP biosynthetic process (GO:0006241)	2.96850709
83	CTP metabolic process (GO:0046036)	2.96850709
84	kinetochore organization (GO:0051383)	2.96150710
85	rRNA modification (GO:0000154)	2.96007967
86	UTP metabolic process (GO:0046051)	2.95360431
87	protein K11-linked ubiquitination (GO:0070979)	2.93517528
88	translation (GO:0006412)	2.93090521
89	guanosine-containing compound biosynthetic process (GO:1901070)	2.92975092
90	folic acid-containing compound biosynthetic process (GO:0009396)	2.92071524
91	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	2.91882886
92	mitochondrial calcium ion transport (GO:0006851)	2.89732367
93	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.86336026
94	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.86138448
95	viral mRNA export from host cell nucleus (GO:0046784)	2.83712940
96	nucleobase-containing small molecule interconversion (GO:0015949)	2.83669895
97	left/right pattern formation (GO:0060972)	2.83451947
98	histone exchange (GO:0043486)	2.82743093
99	telomere maintenance via semi-conservative replication (GO:0032201)	2.82718861
100	pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)	2.80936860

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E2F7_22180533_ChIP-Seq_HELA_Human	6.32989953
2	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	5.35549151
3	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.60589514
4	MYC_18555785_ChIP-Seq_MESCs_Mouse	4.20832262
5	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.82477122
6	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.74843468
7	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	3.58125903
8	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	3.41486914
9	ETS1_20019798_ChIP-Seq_JURKAT_Human	3.37515333
10	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	3.25617948
11	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	3.25579822
12	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.90842022
13	MYC_18358816_ChIP-ChIP_MESCs_Mouse	2.90032013
14	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	2.89767472
15	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.87883734
16	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.84726144
17	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.70465419
18	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.69173033
19	MYC_19030024_ChIP-ChIP_MESCs_Mouse	2.68021752
20	XRN2_22483619_ChIP-Seq_HELA_Human	2.65999679
21	THAP11_20581084_ChIP-Seq_MESCs_Mouse	2.56258455
22	DCP1A_22483619_ChIP-Seq_HELA_Human	2.54787531
23	TTF2_22483619_ChIP-Seq_HELA_Human	2.52343195
24	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.38829689
25	VDR_23849224_ChIP-Seq_CD4+_Human	2.34135152
26	ELK1_19687146_ChIP-ChIP_HELA_Human	2.32334417
27	MYC_19079543_ChIP-ChIP_MESCs_Mouse	2.26526743
28	SRF_21415370_ChIP-Seq_HL-1_Mouse	2.23307358
29	FOXM1_23109430_ChIP-Seq_U2OS_Human	2.17540015
30	E2F1_18555785_ChIP-Seq_MESCs_Mouse	2.16065224
31	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	2.10740944
32	FOXP3_21729870_ChIP-Seq_TREG_Human	2.08448718
33	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.90621464
34	GATA1_22025678_ChIP-Seq_K562_Human	1.85835085
35	MYC_18940864_ChIP-ChIP_HL60_Human	1.84080437
36	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.83385642
37	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.73025088
38	GABP_19822575_ChIP-Seq_HepG2_Human	1.72948081
39	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.63127427
40	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.61357373
41	FUS_26573619_Chip-Seq_HEK293_Human	1.57520897
42	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.56880438
43	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.54610967
44	AR_21909140_ChIP-Seq_LNCAP_Human	1.50142582
45	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.47922689
46	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.47263336
47	ZNF263_19887448_ChIP-Seq_K562_Human	1.41979289
48	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.41206787
49	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.38809903
50	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.36981791
51	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.35757892
52	EWS_26573619_Chip-Seq_HEK293_Human	1.33447146
53	NANOG_18555785_ChIP-Seq_MESCs_Mouse	1.33305951
54	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.32043390
55	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.30801510
56	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.30534743
57	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.27211721
58	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.26974083
59	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.24255541
60	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.23903839
61	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.16510835
62	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	1.16391416
63	CNOT3_19339689_ChIP-ChIP_MESCs_Mouse	1.14165405
64	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.13660518
65	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	1.13522594
66	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	1.13302346
67	MYCN_18555785_ChIP-Seq_MESCs_Mouse	1.11474525
68	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.06691630
69	ZFX_18555785_ChIP-Seq_MESCs_Mouse	1.05904907
70	KDM5A_27292631_Chip-Seq_BREAST_Human	1.04859866
71	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.04040672
72	POU5F1_18700969_ChIP-ChIP_MESCs_Mouse	1.04023504
73	SOX17_20123909_ChIP-Seq_XEN_Mouse	1.03362732
74	NANOG_16153702_ChIP-ChIP_HESCs_Human	1.01837112
75	ERG_20517297_ChIP-Seq_VCAP_Human	1.00232951
76	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	0.99790417
77	CIITA_25753668_ChIP-Seq_RAJI_Human	0.98853808
78	TP63_19390658_ChIP-ChIP_HaCaT_Human	0.96864233
79	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	0.94233294
80	FOXP1_21924763_ChIP-Seq_HESCs_Human	0.93507309
81	GFI1B_20887958_ChIP-Seq_HPC-7_Mouse	0.92964991
82	SRY_22984422_ChIP-ChIP_TESTIS_Rat	0.92671730
83	TRIM28_19339689_ChIP-ChIP_MESCs_Mouse	0.84689713
84	ATF3_23680149_ChIP-Seq_GBM1-GSC_Human	0.84195470
85	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	0.82011633
86	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	0.80504753
87	SOX2_22085726_ChIP-Seq_NPCs_Mouse	0.77087233
88	ZNF274_21170338_ChIP-Seq_K562_Hela	0.75554919
89	ERG_20887958_ChIP-Seq_HPC-7_Mouse	0.74260745
90	SOX2_16153702_ChIP-ChIP_HESCs_Human	0.73637843
91	REST_19997604_ChIP-ChIP_NEURONS_Mouse	0.72701375
92	SIN3A_21632747_ChIP-Seq_MESCs_Mouse	0.72053366
93	ELF1_17652178_ChIP-ChIP_JURKAT_Human	0.71958071
94	CTCF_18555785_ChIP-Seq_MESCs_Mouse	0.69006679
95	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	0.67906214
96	TP53_22573176_ChIP-Seq_HFKS_Human	0.67894977
97	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	0.67844596
98	NANOG_21062744_ChIP-ChIP_HESCs_Human	0.66393720
99	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.65767247
100	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.65475748

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002822_catalepsy	6.30494017
2	MP0001188_hyperpigmentation	5.82485682
3	MP0000372_irregular_coat_pigmentation	4.03837246
4	MP0003136_yellow_coat_color	4.00083468
5	MP0009379_abnormal_foot_pigmentation	3.09606144
6	MP0005171_absent_coat_pigmentation	2.97511132
7	MP0001529_abnormal_vocalization	2.94401180
8	MP0002653_abnormal_ependyma_morphology	2.82808094
9	MP0010094_abnormal_chromosome_stability	2.55824340
10	MP0003806_abnormal_nucleotide_metabolis	2.50626328
11	MP0005646_abnormal_pituitary_gland	2.34192920
12	MP0005409_darkened_coat_color	2.26461139
13	MP0002909_abnormal_adrenal_gland	2.26058763
14	MP0003186_abnormal_redox_activity	2.24078308
15	MP0006036_abnormal_mitochondrial_physio	2.15445787
16	MP0003693_abnormal_embryo_hatching	2.08428634
17	MP0000516_abnormal_urinary_system	2.00565492
18	MP0005367_renal/urinary_system_phenotyp	2.00565492
19	MP0002938_white_spotting	2.00547629
20	MP0003567_abnormal_fetal_cardiomyocyte	1.96741395
21	MP0006072_abnormal_retinal_apoptosis	1.96604110
22	MP0004957_abnormal_blastocyst_morpholog	1.89918768
23	MP0006292_abnormal_olfactory_placode	1.82234067
24	MP0008995_early_reproductive_senescence	1.79021778
25	MP0002254_reproductive_system_inflammat	1.75714063
26	MP0008057_abnormal_DNA_replication	1.74757937
27	MP0003111_abnormal_nucleus_morphology	1.73043927
28	MP0009697_abnormal_copulation	1.71856595
29	MP0001293_anophthalmia	1.67957963
30	MP0006035_abnormal_mitochondrial_morpho	1.65124078
31	MP0001919_abnormal_reproductive_system	1.50937239
32	MP0005084_abnormal_gallbladder_morpholo	1.42330229
33	MP0003077_abnormal_cell_cycle	1.40410929
34	MP0001905_abnormal_dopamine_level	1.36718036
35	MP0004147_increased_porphyrin_level	1.35004343
36	MP0005408_hypopigmentation	1.34973833
37	MP0001485_abnormal_pinna_reflex	1.32909035
38	MP0003786_premature_aging	1.31418310
39	MP0002277_abnormal_respiratory_mucosa	1.31117108
40	MP0004885_abnormal_endolymph	1.29714561
41	MP0005377_hearing/vestibular/ear_phenot	1.28665594
42	MP0003878_abnormal_ear_physiology	1.28665594
43	MP0005410_abnormal_fertilization	1.28214096
44	MP0008932_abnormal_embryonic_tissue	1.25313622
45	MP0000358_abnormal_cell_content/	1.25181516
46	MP0002736_abnormal_nociception_after	1.23688442
47	MP0002102_abnormal_ear_morphology	1.20869348
48	MP0003941_abnormal_skin_development	1.14480694
49	MP0002090_abnormal_vision	1.12859185
50	MP0003315_abnormal_perineum_morphology	1.10242266
51	MP0000343_altered_response_to	1.09642654
52	MP0005389_reproductive_system_phenotype	1.09138376
53	MP0005257_abnormal_intraocular_pressure	1.09103117
54	MP0008007_abnormal_cellular_replicative	1.06521636
55	MP0002210_abnormal_sex_determination	1.06172465
56	MP0005174_abnormal_tail_pigmentation	1.06006664
57	MP0009250_abnormal_appendicular_skeleto	1.05011765
58	MP0002160_abnormal_reproductive_system	1.01438489
59	MP0000534_abnormal_ureter_morphology	0.96611161
60	MP0001186_pigmentation_phenotype	0.95284174
61	MP0008058_abnormal_DNA_repair	0.94548225
62	MP0000490_abnormal_crypts_of	0.93609683
63	MP0002075_abnormal_coat/hair_pigmentati	0.93498479
64	MP0002095_abnormal_skin_pigmentation	0.92901384
65	MP0005253_abnormal_eye_physiology	0.91014025
66	MP0005360_urolithiasis	0.90370655
67	MP0004019_abnormal_vitamin_homeostasis	0.89775129
68	MP0009053_abnormal_anal_canal	0.88317201
69	MP0003195_calcinosis	0.83892632
70	MP0004142_abnormal_muscle_tone	0.83113726
71	MP0008775_abnormal_heart_ventricle	0.83061117
72	MP0008961_abnormal_basal_metabolism	0.83009565
73	MP0003718_maternal_effect	0.79140183
74	MP0005670_abnormal_white_adipose	0.79064115
75	MP0006276_abnormal_autonomic_nervous	0.76488642
76	MP0004145_abnormal_muscle_electrophysio	0.74758696
77	MP0005551_abnormal_eye_electrophysiolog	0.73821228
78	MP0001346_abnormal_lacrimal_gland	0.72813335
79	MP0000639_abnormal_adrenal_gland	0.71870915
80	MP0002877_abnormal_melanocyte_morpholog	0.71859365
81	MP0001145_abnormal_male_reproductive	0.70729081
82	MP0010030_abnormal_orbit_morphology	0.70640313
83	MP0001299_abnormal_eye_distance/	0.68191787
84	MP0002638_abnormal_pupillary_reflex	0.68173025
85	MP0001764_abnormal_homeostasis	0.67467120
86	MP0001756_abnormal_urination	0.65632360
87	MP0002332_abnormal_exercise_endurance	0.64268173
88	MP0000537_abnormal_urethra_morphology	0.62416953
89	MP0000653_abnormal_sex_gland	0.60962063
90	MP0008873_increased_physiological_sensi	0.60631039
91	MP0005391_vision/eye_phenotype	0.60202437
92	MP0001727_abnormal_embryo_implantation	0.59877723
93	MP0001119_abnormal_female_reproductive	0.58349491
94	MP0001929_abnormal_gametogenesis	0.57534336
95	MP0002697_abnormal_eye_size	0.56719381
96	MP0002006_tumorigenesis	0.56288842
97	MP0005330_cardiomyopathy	0.54644099
98	MP0005075_abnormal_melanosome_morpholog	0.54314575
99	MP0002009_preneoplasia	0.53476841
100	MP0005266_abnormal_metabolism	0.53278836

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Increased hepatocellular lipid droplets (HP:0006565)	5.79558624
2	Lipid accumulation in hepatocytes (HP:0006561)	5.36637505
3	Increased CSF lactate (HP:0002490)	4.84576050
4	Mitochondrial inheritance (HP:0001427)	4.78424843
5	Acute necrotizing encephalopathy (HP:0006965)	4.78003443
6	Abnormal mitochondria in muscle tissue (HP:0008316)	4.64525636
7	Hepatocellular necrosis (HP:0001404)	4.64454967
8	Increased intramyocellular lipid droplets (HP:0012240)	4.59707869
9	Renal Fanconi syndrome (HP:0001994)	4.44728807
10	Increased serum pyruvate (HP:0003542)	4.43857549
11	Decreased activity of mitochondrial respiratory chain (HP:0008972)	4.21671068
12	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	4.21671068
13	Acute encephalopathy (HP:0006846)	4.10015804
14	Exertional dyspnea (HP:0002875)	4.07986396
15	Increased muscle lipid content (HP:0009058)	3.87286678
16	Abnormality of glycolysis (HP:0004366)	3.84557956
17	Hepatic necrosis (HP:0002605)	3.77633084
18	Reticulocytopenia (HP:0001896)	3.68785158
19	Progressive macrocephaly (HP:0004481)	3.65760947
20	Abnormal number of erythroid precursors (HP:0012131)	3.35458539
21	Abnormal respiratory motile cilium physiology (HP:0012261)	3.14093391
22	Abnormal ciliary motility (HP:0012262)	3.12434312
23	Abnormality of cells of the erythroid lineage (HP:0012130)	3.08315637
24	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	3.03920906
25	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	2.99028483
26	Increased serum lactate (HP:0002151)	2.90278684
27	Abnormality of renal resorption (HP:0011038)	2.90018785
28	Oral leukoplakia (HP:0002745)	2.85801893
29	Respiratory difficulties (HP:0002880)	2.84260294
30	Cerebral edema (HP:0002181)	2.83358990
31	Poor head control (HP:0002421)	2.81285026
32	Macrocytic anemia (HP:0001972)	2.76444891
33	Abnormality of dentin (HP:0010299)	2.72559050
34	Testicular atrophy (HP:0000029)	2.69870199
35	Absent/shortened dynein arms (HP:0200106)	2.68744843
36	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.68744843
37	Leukodystrophy (HP:0002415)	2.68375996
38	Congenital, generalized hypertrichosis (HP:0004540)	2.63437929
39	Progressive microcephaly (HP:0000253)	2.61929135
40	Abnormal number of incisors (HP:0011064)	2.58554109
41	Respiratory failure (HP:0002878)	2.58000929
42	3-Methylglutaconic aciduria (HP:0003535)	2.57887932
43	Birth length less than 3rd percentile (HP:0003561)	2.55859642
44	Abnormality of placental membranes (HP:0011409)	2.48668918
45	Amniotic constriction ring (HP:0009775)	2.48668918
46	Abnormal respiratory motile cilium morphology (HP:0005938)	2.48446746
47	Abnormal respiratory epithelium morphology (HP:0012253)	2.48446746
48	Lactic acidosis (HP:0003128)	2.48359465
49	Hyperinsulinemic hypoglycemia (HP:0000825)	2.44663973
50	Exercise intolerance (HP:0003546)	2.44427837
51	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.42730303
52	Absent thumb (HP:0009777)	2.39369222
53	Molar tooth sign on MRI (HP:0002419)	2.38332243
54	Abnormality of midbrain morphology (HP:0002418)	2.38332243
55	Generalized aminoaciduria (HP:0002909)	2.34067452
56	Orthostatic hypotension (HP:0001278)	2.33025308
57	Pallor (HP:0000980)	2.32424402
58	Pancytopenia (HP:0001876)	2.26206120
59	Fibular hypoplasia (HP:0003038)	2.25986116
60	Type I transferrin isoform profile (HP:0003642)	2.24129765
61	Hypothermia (HP:0002045)	2.23512286
62	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.22064891
63	Meckel diverticulum (HP:0002245)	2.20873678
64	Optic disc pallor (HP:0000543)	2.17543482
65	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.15245153
66	Aplastic anemia (HP:0001915)	2.10406614
67	Cleft eyelid (HP:0000625)	2.08789654
68	Ragged-red muscle fibers (HP:0003200)	2.03672041
69	Tinnitus (HP:0000360)	2.02657544
70	Wide nose (HP:0000445)	2.02640106
71	Midline defect of the nose (HP:0004122)	2.01653176
72	Nephronophthisis (HP:0000090)	1.97627363
73	Lethargy (HP:0001254)	1.94823792
74	Chromsome breakage (HP:0040012)	1.92616160
75	Abnormality of the ileum (HP:0001549)	1.91624433
76	Abnormality of cochlea (HP:0000375)	1.89615118
77	Abnormality of the preputium (HP:0100587)	1.86360467
78	Hyperphosphaturia (HP:0003109)	1.84061686
79	Abnormal protein glycosylation (HP:0012346)	1.82736742
80	Abnormal glycosylation (HP:0012345)	1.82736742
81	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.82736742
82	Abnormal protein N-linked glycosylation (HP:0012347)	1.82736742
83	Hypoplasia of the radius (HP:0002984)	1.82734383
84	Craniofacial dystonia (HP:0012179)	1.81212837
85	Rough bone trabeculation (HP:0100670)	1.79233411
86	Short thumb (HP:0009778)	1.79229952
87	Megaloblastic anemia (HP:0001889)	1.78571964
88	Abnormal autonomic nervous system physiology (HP:0012332)	1.77128156
89	Rhinitis (HP:0012384)	1.76522630
90	Short tibia (HP:0005736)	1.73616532
91	Nasolacrimal duct obstruction (HP:0000579)	1.73372133
92	Aplasia/Hypoplasia of the patella (HP:0006498)	1.72636774
93	Ileus (HP:0002595)	1.71381800
94	Sclerocornea (HP:0000647)	1.70407703
95	Pancreatic cysts (HP:0001737)	1.70098995
96	Hypoplastic heart (HP:0001961)	1.66385659
97	Microvesicular hepatic steatosis (HP:0001414)	1.66290853
98	Emotional lability (HP:0000712)	1.66133187
99	CNS demyelination (HP:0007305)	1.64071719
100	Male infertility (HP:0003251)	1.63094618

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	CAMKK2	4.13769019
2	BUB1	3.86210016
3	BMPR1B	3.82472670
4	MST1R	3.26946565
5	CDC7	3.07270325
6	CAMK1D	3.00471176
7	NME2	2.97306924
8	WEE1	2.77957895
9	VRK2	2.77829516
10	NME1	2.43447848
11	EIF2AK1	2.38906614
12	PNCK	2.38610172
13	CAMK1G	2.28492631
14	SCYL2	2.08237107
15	MAPK15	2.06612486
16	DYRK2	1.92554628
17	KDR	1.77064172
18	SRPK1	1.65677477
19	MAP4K2	1.58106755
20	FLT3	1.55283922
21	ARAF	1.55039641
22	BRSK2	1.54446431
23	CDK8	1.51329105
24	NEK1	1.48294790
25	STK16	1.48036912
26	PKN2	1.41688871
27	VRK1	1.40196723
28	MET	1.34156745
29	TTK	1.30391691
30	TSSK6	1.28064511
31	BMPR2	1.23493920
32	EPHB2	1.16227169
33	ABL2	1.15904523
34	AURKA	1.15131179
35	GRK6	1.13956738
36	CAMKK1	1.13586990
37	BMX	1.12446319
38	TLK1	1.12182871
39	RPS6KA5	1.10162871
40	MAP2K3	1.07080717
41	EPHA3	1.04266503
42	PIM2	1.00982532
43	TESK1	1.00322503
44	RPS6KA4	0.97610954
45	MST4	0.97506514
46	MAP3K10	0.91979833
47	NEK2	0.90250126
48	MAP3K12	0.88748271
49	NLK	0.86563803
50	MATK	0.85160992
51	IRAK3	0.83815829
52	CLK1	0.82520828
53	TAOK1	0.77627786
54	PLK1	0.77079569
55	MAP2K6	0.72970406
56	TGFBR1	0.69443828
57	PLK3	0.67930007
58	PBK	0.67010113
59	MAP3K8	0.66558489
60	AURKB	0.64439913
61	BRSK1	0.63350304
62	MKNK2	0.62228186
63	NTRK1	0.61539200
64	CHEK2	0.60242669
65	DYRK3	0.59320762
66	PTK2B	0.59108003
67	PLK4	0.57193291
68	DAPK1	0.55831993
69	LRRK2	0.55804629
70	TNIK	0.55724144
71	MINK1	0.54921106
72	WNK4	0.53906191
73	MOS	0.52629869
74	WNK3	0.51371545
75	MYLK	0.50594378
76	ERBB4	0.50299179
77	BRAF	0.49604245
78	ATR	0.48684672
79	CSNK2A1	0.47713294
80	PAK1	0.46020259
81	MAP3K2	0.44885134
82	CSNK1G1	0.44440939
83	ILK	0.44399801
84	MAP2K4	0.40509425
85	DAPK3	0.40176165
86	STK4	0.38052396
87	CHEK1	0.37726477
88	STK3	0.37112525
89	ZAK	0.36180346
90	MELK	0.35285826
91	CSNK2A2	0.33493929
92	CDK4	0.32474156
93	PRKCG	0.31583991
94	PRKCE	0.31296566
95	CDK3	0.30302519
96	ADRBK2	0.29752479
97	MKNK1	0.28567443
98	PIM1	0.28467940
99	EIF2AK2	0.27804829
100	PRKD2	0.26689007

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Oxidative phosphorylation_Homo sapiens_hsa00190	5.05592087
2	Parkinsons disease_Homo sapiens_hsa05012	4.51287919
3	Ribosome_Homo sapiens_hsa03010	4.12924444
4	RNA polymerase_Homo sapiens_hsa03020	3.89893107
5	Proteasome_Homo sapiens_hsa03050	3.72474815
6	Huntingtons disease_Homo sapiens_hsa05016	3.57343299
7	Alzheimers disease_Homo sapiens_hsa05010	2.98395137
8	DNA replication_Homo sapiens_hsa03030	2.96829115
9	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.61513278
10	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.55377769
11	Protein export_Homo sapiens_hsa03060	2.46812327
12	One carbon pool by folate_Homo sapiens_hsa00670	2.40883706
13	Pyrimidine metabolism_Homo sapiens_hsa00240	2.26742847
14	Mismatch repair_Homo sapiens_hsa03430	2.23905182
15	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.22690837
16	Spliceosome_Homo sapiens_hsa03040	2.19188751
17	Homologous recombination_Homo sapiens_hsa03440	2.09977092
18	Cardiac muscle contraction_Homo sapiens_hsa04260	2.03842718
19	Fanconi anemia pathway_Homo sapiens_hsa03460	1.88577814
20	RNA transport_Homo sapiens_hsa03013	1.70580112
21	Nucleotide excision repair_Homo sapiens_hsa03420	1.64057267
22	Non-homologous end-joining_Homo sapiens_hsa03450	1.62060429
23	Folate biosynthesis_Homo sapiens_hsa00790	1.56908946
24	Sulfur relay system_Homo sapiens_hsa04122	1.56233881
25	Cell cycle_Homo sapiens_hsa04110	1.37096150
26	Purine metabolism_Homo sapiens_hsa00230	1.32768163
27	Base excision repair_Homo sapiens_hsa03410	1.29186794
28	Glutathione metabolism_Homo sapiens_hsa00480	1.28545651
29	Selenocompound metabolism_Homo sapiens_hsa00450	1.24352421
30	RNA degradation_Homo sapiens_hsa03018	1.20972287
31	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.10499047
32	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.06422100
33	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.04458432
34	Pyruvate metabolism_Homo sapiens_hsa00620	0.97190397
35	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.95554481
36	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.88520060
37	Phototransduction_Homo sapiens_hsa04744	0.86927913
38	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.84365293
39	Basal transcription factors_Homo sapiens_hsa03022	0.83966053
40	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.78951066
41	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.78266331
42	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.77876921
43	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.77721265
44	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.77307237
45	Metabolic pathways_Homo sapiens_hsa01100	0.71382728
46	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.67557405
47	Asthma_Homo sapiens_hsa05310	0.62217699
48	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.58118674
49	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.54685289
50	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.52060962
51	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.50418684
52	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.50369012
53	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.47271140
54	Oocyte meiosis_Homo sapiens_hsa04114	0.44502875
55	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.44495539
56	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.41589926
57	mRNA surveillance pathway_Homo sapiens_hsa03015	0.41130352
58	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.41018336
59	Alcoholism_Homo sapiens_hsa05034	0.39535380
60	Galactose metabolism_Homo sapiens_hsa00052	0.38892391
61	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.38634383
62	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.37117869
63	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.36929285
64	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.36500314
65	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.34884397
66	Chemical carcinogenesis_Homo sapiens_hsa05204	0.34248968
67	Collecting duct acid secretion_Homo sapiens_hsa04966	0.31838964
68	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.31233039
69	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.28559871
70	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.27834229
71	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.27314931
72	Propanoate metabolism_Homo sapiens_hsa00640	0.27265146
73	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.25035901
74	Type I diabetes mellitus_Homo sapiens_hsa04940	0.24248275
75	Tyrosine metabolism_Homo sapiens_hsa00350	0.23663163
76	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.23632708
77	Rheumatoid arthritis_Homo sapiens_hsa05323	0.23536538
78	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.23387058
79	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.22630356
80	Nicotine addiction_Homo sapiens_hsa05033	0.20437824
81	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.18881218
82	Steroid biosynthesis_Homo sapiens_hsa00100	0.17942161
83	Vibrio cholerae infection_Homo sapiens_hsa05110	0.16561590
84	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.15208626
85	Legionellosis_Homo sapiens_hsa05134	0.14034047
86	Cocaine addiction_Homo sapiens_hsa05030	0.13812612
87	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.13757374
88	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.12859182
89	Sphingolipid metabolism_Homo sapiens_hsa00600	0.11950948
90	Shigellosis_Homo sapiens_hsa05131	0.11846774
91	Salmonella infection_Homo sapiens_hsa05132	0.10878874
92	Sulfur metabolism_Homo sapiens_hsa00920	0.10249318
93	Carbon metabolism_Homo sapiens_hsa01200	0.08978879
94	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.08671735
95	Fatty acid elongation_Homo sapiens_hsa00062	0.08280153
96	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.06566760
97	Allograft rejection_Homo sapiens_hsa05330	0.05794232
98	Fat digestion and absorption_Homo sapiens_hsa04975	0.05551080
99	Pentose phosphate pathway_Homo sapiens_hsa00030	0.05550749
100	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.05447426

PLA2G12AP1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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