PLA2G12B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the phospholipase A2 (PLA2) group of enzymes, which function in glycolipid hydrolysis with the release of free fatty acids and lysophospholipids. This family member has altered phospholipid-binding properties and is catalytically inactive. The protein is secreted, and together with microsomal triglyceride transfer protein, it functions to regulate HNF4alpha-induced hepatitis C virus infectivity. The expression of this gene is down-regulated in various tumors, suggesting that it may function as a negative regulator of tumor progression. Alternative splicing of this gene results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.34317658
2L-phenylalanine catabolic process (GO:0006559)7.34317658
3exogenous drug catabolic process (GO:0042738)7.31493093
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.06437449
5L-phenylalanine metabolic process (GO:0006558)7.06437449
6epoxygenase P450 pathway (GO:0019373)6.92208265
7triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.76102026
8aromatic amino acid family catabolic process (GO:0009074)6.58281229
9tryptophan catabolic process (GO:0006569)5.92518011
10indole-containing compound catabolic process (GO:0042436)5.92518011
11indolalkylamine catabolic process (GO:0046218)5.92518011
12high-density lipoprotein particle remodeling (GO:0034375)5.90888688
13kynurenine metabolic process (GO:0070189)5.83346667
14bile acid biosynthetic process (GO:0006699)5.77675111
15glyoxylate metabolic process (GO:0046487)5.76711225
16negative regulation of fibrinolysis (GO:0051918)5.73388528
17urea metabolic process (GO:0019627)5.68139391
18urea cycle (GO:0000050)5.68139391
19drug metabolic process (GO:0017144)5.67586904
20tryptophan metabolic process (GO:0006568)5.58901329
21regulation of fibrinolysis (GO:0051917)5.48972206
22sulfur amino acid catabolic process (GO:0000098)5.39969268
23cysteine metabolic process (GO:0006534)5.39515570
24alpha-linolenic acid metabolic process (GO:0036109)5.36837789
25omega-hydroxylase P450 pathway (GO:0097267)5.34220745
26peptidyl-glutamic acid carboxylation (GO:0017187)5.31098569
27protein carboxylation (GO:0018214)5.31098569
28regulation of protein activation cascade (GO:2000257)5.29960834
29reverse cholesterol transport (GO:0043691)5.28100998
30regulation of cholesterol esterification (GO:0010872)5.25695832
31complement activation, alternative pathway (GO:0006957)5.22542058
32nitrogen cycle metabolic process (GO:0071941)5.21836405
33regulation of triglyceride catabolic process (GO:0010896)5.17840949
34plasma lipoprotein particle remodeling (GO:0034369)5.06169764
35protein-lipid complex remodeling (GO:0034368)5.06169764
36macromolecular complex remodeling (GO:0034367)5.06169764
37serine family amino acid catabolic process (GO:0009071)5.02567373
38phospholipid efflux (GO:0033700)5.00120951
39bile acid metabolic process (GO:0008206)4.96083071
40regulation of complement activation (GO:0030449)4.92953197
41fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.80956626
42aromatic amino acid family metabolic process (GO:0009072)4.79922126
43fat-soluble vitamin biosynthetic process (GO:0042362)4.77970519
44phenylpropanoid metabolic process (GO:0009698)4.77370294
45negative regulation of sterol transport (GO:0032372)4.73309300
46negative regulation of cholesterol transport (GO:0032375)4.73309300
47homocysteine metabolic process (GO:0050667)4.71909519
48cellular ketone body metabolic process (GO:0046950)4.64303341
49tyrosine metabolic process (GO:0006570)4.63449388
50plasma lipoprotein particle clearance (GO:0034381)4.62063819
51cholesterol efflux (GO:0033344)4.54406554
52heme transport (GO:0015886)4.54172907
53* triglyceride homeostasis (GO:0070328)4.53719553
54* acylglycerol homeostasis (GO:0055090)4.53719553
55oxidative demethylation (GO:0070989)4.52473026
56amino-acid betaine metabolic process (GO:0006577)4.51330057
57alpha-amino acid catabolic process (GO:1901606)4.50855243
58lysine metabolic process (GO:0006553)4.50393737
59lysine catabolic process (GO:0006554)4.50393737
60hormone catabolic process (GO:0042447)4.46340764
61bile acid and bile salt transport (GO:0015721)4.42400902
62plasma lipoprotein particle assembly (GO:0034377)4.39744597
63negative regulation of blood coagulation (GO:0030195)4.39667271
64negative regulation of hemostasis (GO:1900047)4.39667271
65glycine metabolic process (GO:0006544)4.38320641
66regulation of plasminogen activation (GO:0010755)4.28111658
67lipoprotein transport (GO:0042953)4.27331652
68cellular glucuronidation (GO:0052695)4.24619481
69positive regulation of triglyceride lipase activity (GO:0061365)4.22143071
70positive regulation of lipoprotein lipase activity (GO:0051006)4.22143071
71positive regulation of heterotypic cell-cell adhesion (GO:0034116)4.21107494
72indolalkylamine metabolic process (GO:0006586)4.20116880
73alkaloid metabolic process (GO:0009820)4.18977613
74coenzyme catabolic process (GO:0009109)4.18308775
75serine family amino acid metabolic process (GO:0009069)4.16956808
76imidazole-containing compound metabolic process (GO:0052803)4.16878909
77cellular amino acid catabolic process (GO:0009063)4.16764037
78glutamate metabolic process (GO:0006536)4.16560271
79cellular biogenic amine catabolic process (GO:0042402)4.10039749
80amine catabolic process (GO:0009310)4.10039749
81serine family amino acid biosynthetic process (GO:0009070)4.08055905
82fibrinolysis (GO:0042730)4.04718909
83aldehyde catabolic process (GO:0046185)4.04057897
84arginine metabolic process (GO:0006525)4.03521895
85negative regulation of coagulation (GO:0050819)4.03273506
86ketone body metabolic process (GO:1902224)4.01746537
87ethanol oxidation (GO:0006069)4.01594317
88low-density lipoprotein particle remodeling (GO:0034374)4.00671893
89benzene-containing compound metabolic process (GO:0042537)3.99920741
90cellular modified amino acid catabolic process (GO:0042219)3.99460335
91intestinal absorption (GO:0050892)3.99103167
92protein-lipid complex assembly (GO:0065005)3.96605806
93drug catabolic process (GO:0042737)3.96124527
94very-low-density lipoprotein particle assembly (GO:0034379)3.95565848
95dicarboxylic acid biosynthetic process (GO:0043650)3.95229082
96daunorubicin metabolic process (GO:0044597)3.91205964
97polyketide metabolic process (GO:0030638)3.91205964
98doxorubicin metabolic process (GO:0044598)3.91205964
99negative regulation of wound healing (GO:0061045)3.90999762
100plasma lipoprotein particle organization (GO:0071827)3.88945430
101blood coagulation, intrinsic pathway (GO:0007597)3.86585859
102positive regulation of lipid catabolic process (GO:0050996)3.85104257
103phospholipid homeostasis (GO:0055091)3.84796939
104* cholesterol homeostasis (GO:0042632)3.82195708
105regulation of bile acid biosynthetic process (GO:0070857)3.77228536
106glucuronate metabolic process (GO:0019585)3.77098561
107uronic acid metabolic process (GO:0006063)3.77098561
108negative regulation of lipase activity (GO:0060192)3.76601768
109* sterol homeostasis (GO:0055092)3.75919084
110regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.75869943
111lipoprotein metabolic process (GO:0042157)3.75567181
112intestinal cholesterol absorption (GO:0030299)3.70808483
113flavonoid metabolic process (GO:0009812)3.70804213
114complement activation, classical pathway (GO:0006958)3.70089722
115ethanol metabolic process (GO:0006067)3.68561440
116cofactor catabolic process (GO:0051187)3.68521663
117protein activation cascade (GO:0072376)3.68196428
118protein-lipid complex subunit organization (GO:0071825)3.67174466
119carboxylic acid catabolic process (GO:0046395)3.65480837
120organic acid catabolic process (GO:0016054)3.65480837
121drug transmembrane transport (GO:0006855)3.65276128
122regulation of cholesterol homeostasis (GO:2000188)3.64789870
123response to nitrosative stress (GO:0051409)3.64293434
124complement activation (GO:0006956)3.63861991
125aminoglycoside antibiotic metabolic process (GO:0030647)3.55235822
126drug transport (GO:0015893)3.55164419
127negative regulation of protein activation cascade (GO:2000258)3.53003399
128primary alcohol catabolic process (GO:0034310)3.49325626
129glutamine family amino acid biosynthetic process (GO:0009084)3.40404711
130sterol transport (GO:0015918)3.38793749
131cholesterol transport (GO:0030301)3.38793749
132angiotensin maturation (GO:0002003)3.38139567
133xenobiotic metabolic process (GO:0006805)3.37937738
134regulation of sterol transport (GO:0032371)3.35117654
135regulation of cholesterol transport (GO:0032374)3.35117654
136steroid catabolic process (GO:0006706)3.34705651

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse8.33153488
2PPARA_22158963_ChIP-Seq_LIVER_Mouse7.22300128
3EGR1_23403033_ChIP-Seq_LIVER_Mouse7.01539544
4LXR_22158963_ChIP-Seq_LIVER_Mouse6.45046654
5CEBPA_23403033_ChIP-Seq_LIVER_Mouse5.16485473
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.15959948
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.92342341
8CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.98089181
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.97242849
10* HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.19235442
11TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.04222847
12ESR1_17901129_ChIP-ChIP_LIVER_Mouse12.0396370
13TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.99266418
14FOXA2_19822575_ChIP-Seq_HepG2_Human1.59677266
15CLOCK_20551151_ChIP-Seq_293T_Human1.59234496
16HTT_18923047_ChIP-ChIP_STHdh_Human1.50742559
17* HNF4A_19822575_ChIP-Seq_HepG2_Human1.44705781
18GATA1_22025678_ChIP-Seq_K562_Human1.40700357
19CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.30904003
20TCF4_18268006_ChIP-ChIP_LS174T_Human1.28614202
21THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.28246482
22GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.25760959
23STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.23880381
24RXRA_24833708_ChIP-Seq_LIVER_Mouse1.21886486
25FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.19385651
26STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.14119834
27SOX2_27498859_Chip-Seq_STOMACH_Mouse1.11495126
28ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.09413941
29ESR1_15608294_ChIP-ChIP_MCF-7_Human1.08868377
30TRIM28_21343339_ChIP-Seq_HEK293_Human1.07263350
31PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.06713005
32MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.06343377
33TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.04460709
34IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.01253670
35ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.98580142
36* GATA4_25053715_ChIP-Seq_YYC3_Human0.95450632
37* CDX2_19796622_ChIP-Seq_MESCs_Mouse0.94731544
38PCGF2_27294783_Chip-Seq_NPCs_Mouse0.94379394
39PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.91708072
40NFE2_27457419_Chip-Seq_LIVER_Mouse0.91049493
41ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.85632130
42RARG_19884340_ChIP-ChIP_MEFs_Mouse0.84689987
43ZNF263_19887448_ChIP-Seq_K562_Human0.83021848
44* HNFA_21074721_ChIP-Seq_CACO-2_Human0.82047432
45SALL4_18804426_ChIP-ChIP_XEN_Mouse0.81846232
46KAP1_22055183_ChIP-Seq_ESCs_Mouse0.81335963
47CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.80533182
48PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.79765533
49AUTS2_25519132_ChIP-Seq_293T-REX_Human0.79687870
50AR_21909140_ChIP-Seq_LNCAP_Human0.78703077
51RARA_24833708_ChIP-Seq_LIVER_Mouse0.78638405
52IRF8_22096565_ChIP-ChIP_GC-B_Human0.78199156
53SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.77934219
54SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.76054723
55FOXA1_21572438_ChIP-Seq_LNCaP_Human0.74737122
56ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.74111645
57NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.73335240
58SOX2_21211035_ChIP-Seq_LN229_Human0.72024892
59CDX2_20551321_ChIP-Seq_CACO-2_Human0.71195817
60BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.71123437
61SUZ12_27294783_Chip-Seq_NPCs_Mouse0.70242213
62SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.69473659
63ESR2_21235772_ChIP-Seq_MCF-7_Human0.69342910
64TP53_18474530_ChIP-ChIP_U2OS_Human0.68127926
65CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.68063478
66* PHF8_20622853_ChIP-Seq_HELA_Human0.67840878
67AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.67817393
68Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.67193309
69RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.67129038
70TCF4_22108803_ChIP-Seq_LS180_Human0.66606094
71RARB_24833708_ChIP-Seq_LIVER_Mouse0.66276590
72NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.65192614
73CBX2_22325352_ChIP-Seq_293T-Rex_Human0.64997995
74GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.64825273
75SMAD1_18555785_Chip-Seq_ESCs_Mouse0.64622552
76BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.64599390
77* EZH2_27294783_Chip-Seq_NPCs_Mouse0.64412745
78EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.63730383
79NFYA_21822215_ChIP-Seq_K562_Human0.63425989
80RAD21_21589869_ChIP-Seq_MESCs_Mouse0.63239644
81STAT3_1855785_ChIP-Seq_MESCs_Mouse0.62404230
82ESRRB_18555785_Chip-Seq_ESCs_Mouse0.61915077
83* KLF5_20875108_ChIP-Seq_MESCs_Mouse0.61797034
84FOXH1_21741376_ChIP-Seq_EPCs_Human0.61534372
85SOX2_22085726_ChIP-Seq_NPCs_Mouse0.61076245
86ZFX_18555785_Chip-Seq_ESCs_Mouse0.60688613
87FOXA1_25329375_ChIP-Seq_VCAP_Human0.60217783
88FOXA1_27270436_Chip-Seq_PROSTATE_Human0.60217783
89CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.59483454
90RUNX1_27457419_Chip-Seq_LIVER_Mouse0.59170203
91ETV1_20927104_ChIP-Seq_GIST48_Human0.58845238
92CEBPB_22108803_ChIP-Seq_LS180_Human0.58477841
93PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.58295588
94ETV2_25802403_ChIP-Seq_MESCs_Mouse0.57889942
95NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.57881875
96NRF2_20460467_ChIP-Seq_MEFs_Mouse0.57881875
97TP53_16413492_ChIP-PET_HCT116_Human0.57795077
98GATA6_21074721_ChIP-Seq_CACO-2_Human0.57551875
99EGR1_19032775_ChIP-ChIP_M12_Human0.56909895
100LXR_22292898_ChIP-Seq_THP-1_Human0.55376568
101PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.54039448
102* GATA6_25053715_ChIP-Seq_YYC3_Human0.53986481
103MYC_19915707_ChIP-ChIP_AK7_Human0.53501758
104PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.53180735
105FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.52858865
106* FOXA1_25552417_ChIP-Seq_VCAP_Human0.51160419
107* AR_20517297_ChIP-Seq_VCAP_Human0.51053279
108* FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.49388217
109PPAR_26484153_Chip-Seq_NCI-H1993_Human0.48483812
110ESET_19884257_ChIP-Seq_ESCs_Mouse0.48429743
111NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.47686924
112ESR1_21235772_ChIP-Seq_MCF-7_Human0.47673797
113P53_21459846_ChIP-Seq_SAOS-2_Human0.47119181
114STAT1_17558387_ChIP-Seq_HELA_Human0.46577649
115FOXO3_23340844_ChIP-Seq_DLD1_Human0.46331804
116TAF2_19829295_ChIP-Seq_ESCs_Human0.45280435
117GATA1_19941826_ChIP-Seq_K562_Human0.45091673
118* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.44990565
119GATA2_19941826_ChIP-Seq_K562_Human0.44586884
120* CBP_21632823_ChIP-Seq_H3396_Human0.43918281
121* PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.43403661
122SOX2_20726797_ChIP-Seq_SW620_Human0.43334394
123GATA1_19941827_ChIP-Seq_MEL_Mouse0.43063691
124PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.42966237
125SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.42935823
126FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.40080156
127ESR1_20079471_ChIP-ChIP_T-47D_Human0.39632147
128E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.38356602
129CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.38190700
130SPI1_26923725_Chip-Seq_HPCs_Mouse0.37186205
131STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.36909715
132BCOR_27268052_Chip-Seq_Bcells_Human0.36718864
133ERG_21242973_ChIP-ChIP_JURKAT_Human0.36146187
134MYC_27129775_Chip-Seq_CORNEA_Mouse0.35986005
135ERG_20517297_ChIP-Seq_VCAP_Human0.35651438
136GATA3_24758297_ChIP-Seq_MCF-7_Human0.35503312
137SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.35475781
138GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.34805378
139SOX3_22085726_ChIP-Seq_MUSCLE_Mouse0.34026664
140BCAT_22108803_ChIP-Seq_LS180_Human0.33768445
141CDX2_22108803_ChIP-Seq_LS180_Human0.33739284

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.21747279
2MP0005360_urolithiasis7.85796853
3MP0005085_abnormal_gallbladder_physiolo6.33040207
4MP0005365_abnormal_bile_salt6.05080352
5MP0008875_abnormal_xenobiotic_pharmacok4.96773736
6MP0003806_abnormal_nucleotide_metabolis4.32745865
7MP0003252_abnormal_bile_duct3.89331004
8MP0010329_abnormal_lipoprotein_level3.68973263
9MP0009840_abnormal_foam_cell3.58247698
10MP0005083_abnormal_biliary_tract2.90224226
11MP0001666_abnormal_nutrient_absorption2.86201769
12MP0005332_abnormal_amino_acid2.71856721
13MP0003195_calcinosis2.64938551
14MP0003191_abnormal_cellular_cholesterol2.46954787
15MP0004019_abnormal_vitamin_homeostasis2.21091206
16MP0000609_abnormal_liver_physiology2.14674290
17MP0002118_abnormal_lipid_homeostasis2.07533168
18MP0002138_abnormal_hepatobiliary_system1.87675099
19MP0003868_abnormal_feces_composition1.86237298
20MP0005319_abnormal_enzyme/_coenzyme1.78895457
21MP0009697_abnormal_copulation1.73199295
22MP0001764_abnormal_homeostasis1.69112448
23MP0005584_abnormal_enzyme/coenzyme_acti1.54379362
24MP0005451_abnormal_body_composition1.51147019
25MP0003183_abnormal_peptide_metabolism1.49864684
26MP0003011_delayed_dark_adaptation1.45018331
27MP0003656_abnormal_erythrocyte_physiolo1.29707215
28MP0009643_abnormal_urine_homeostasis1.26560719
29MP0003186_abnormal_redox_activity1.24669597
30MP0003705_abnormal_hypodermis_morpholog1.23016208
31MP0000598_abnormal_liver_morphology1.17028761
32MP0000604_amyloidosis1.09318745
33MP0005647_abnormal_sex_gland1.04689038
34MP0002254_reproductive_system_inflammat1.03835081
35MP0009764_decreased_sensitivity_to0.99936232
36MP0009763_increased_sensitivity_to0.98175969
37MP0005636_abnormal_mineral_homeostasis0.96466555
38MP0005084_abnormal_gallbladder_morpholo0.93118849
39MP0010368_abnormal_lymphatic_system0.92902457
40MP0009642_abnormal_blood_homeostasis0.87789216
41MP0008469_abnormal_protein_level0.87629699
42MP0005408_hypopigmentation0.86551395
43MP0003879_abnormal_hair_cell0.86190661
44MP0005376_homeostasis/metabolism_phenot0.83756337
45MP0006036_abnormal_mitochondrial_physio0.82049203
46MP0002876_abnormal_thyroid_physiology0.78974823
47MP0009765_abnormal_xenobiotic_induced0.76808740
48MP0002078_abnormal_glucose_homeostasis0.75351453
49MP0005266_abnormal_metabolism0.70897327
50MP0009053_abnormal_anal_canal0.70472386
51MP0002971_abnormal_brown_adipose0.67534501
52MP0005220_abnormal_exocrine_pancreas0.66487962
53MP0005334_abnormal_fat_pad0.64878527
54MP0001986_abnormal_taste_sensitivity0.64492773
55MP0005058_abnormal_lysosome_morphology0.63212843
56MP0005670_abnormal_white_adipose0.61870463
57MP0000566_synostosis0.61656313
58MP0005535_abnormal_body_temperature0.61628578
59MP0003718_maternal_effect0.60513685
60MP0005409_darkened_coat_color0.60100829
61MP0005448_abnormal_energy_balance0.59780803
62MP0003329_amyloid_beta_deposits0.59365465
63MP0000639_abnormal_adrenal_gland0.58975429
64MP0001756_abnormal_urination0.58440690
65MP0003690_abnormal_glial_cell0.58153135
66MP0004130_abnormal_muscle_cell0.57845072
67MP0001661_extended_life_span0.57683638
68MP0006035_abnormal_mitochondrial_morpho0.56233914
69MP0005464_abnormal_platelet_physiology0.54503250
70MP0001915_intracranial_hemorrhage0.54153142
71MP0002822_catalepsy0.52586320
72MP0004264_abnormal_extraembryonic_tissu0.51466128
73MP0010155_abnormal_intestine_physiology0.51212232
74MP0005395_other_phenotype0.50599217
75MP0002089_abnormal_postnatal_growth/wei0.46962485
76MP0002136_abnormal_kidney_physiology0.46939566
77MP0008873_increased_physiological_sensi0.46711371
78MP0003638_abnormal_response/metabolism_0.46108212
79MP0002796_impaired_skin_barrier0.43376223
80MP0005023_abnormal_wound_healing0.43349933
81MP0005187_abnormal_penis_morphology0.43025882
82MP0003941_abnormal_skin_development0.41256896
83MP0004782_abnormal_surfactant_physiolog0.41256264
84MP0005166_decreased_susceptibility_to0.41053374
85MP0003953_abnormal_hormone_level0.40352882
86MP0008872_abnormal_physiological_respon0.39723025
87MP0003436_decreased_susceptibility_to0.38841683
88MP0008874_decreased_physiological_sensi0.38050699
89MP0002928_abnormal_bile_duct0.37928166
90MP0003075_altered_response_to0.37722955
91MP0005248_abnormal_Harderian_gland0.37524592
92MP0009384_cardiac_valve_regurgitation0.37252582
93MP0002090_abnormal_vision0.36807349
94MP0009672_abnormal_birth_weight0.36291996
95MP0010234_abnormal_vibrissa_follicle0.34891610
96MP0003724_increased_susceptibility_to0.34705158
97MP0009115_abnormal_fat_cell0.34473520
98MP0009379_abnormal_foot_pigmentation0.34426187
99MP0005666_abnormal_adipose_tissue0.33615685
100MP0004883_abnormal_blood_vessel0.33251286
101MP0000579_abnormal_nail_morphology0.32594888
102MP0000249_abnormal_blood_vessel0.32493536
103MP0004272_abnormal_basement_membrane0.32072374
104MP0002837_dystrophic_cardiac_calcinosis0.32012368
105MP0001664_abnormal_digestion0.31403734
106MP0001243_abnormal_dermal_layer0.30673886
107MP0004381_abnormal_hair_follicle0.30480101
108MP0000230_abnormal_systemic_arterial0.29533124
109MP0005410_abnormal_fertilization0.29478421
110MP0002132_abnormal_respiratory_system0.29252095
111MP0001845_abnormal_inflammatory_respons0.28890320
112MP0006082_CNS_inflammation0.28759467
113MP0001881_abnormal_mammary_gland0.28382059
114MP0002970_abnormal_white_adipose0.27020413
115MP0005164_abnormal_response_to0.26747419
116MP0000477_abnormal_intestine_morphology0.26372479
117MP0004147_increased_porphyrin_level0.26055929
118MP0000538_abnormal_urinary_bladder0.24895947
119MP0002168_other_aberrant_phenotype0.24385715
120MP0003453_abnormal_keratinocyte_physiol0.23630566
121MP0001765_abnormal_ion_homeostasis0.22919469
122MP0003890_abnormal_embryonic-extraembry0.20919184
123MP0002135_abnormal_kidney_morphology0.20227804
124MP0001324_abnormal_eye_pigmentation0.19298106
125MP0003699_abnormal_female_reproductive0.18025741
126MP0005551_abnormal_eye_electrophysiolog0.17782051
127MP0003632_abnormal_nervous_system0.17374480
128MP0001663_abnormal_digestive_system0.16741919

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)7.37792970
2Intrahepatic cholestasis (HP:0001406)7.21523926
3Abnormality of aromatic amino acid family metabolism (HP:0004338)7.19482922
4Hypobetalipoproteinemia (HP:0003563)6.66253775
5Abnormality of monocarboxylic acid metabolism (HP:0010996)6.56870529
6Prolonged partial thromboplastin time (HP:0003645)6.46268647
7Xanthomatosis (HP:0000991)6.30543676
8Hyperlipoproteinemia (HP:0010980)5.42987705
9Complement deficiency (HP:0004431)5.28212820
10Hypolipoproteinemia (HP:0010981)4.98835376
11Joint hemorrhage (HP:0005261)4.75225840
12Hyperammonemia (HP:0001987)4.60657515
13Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.51668810
14Abnormality of the common coagulation pathway (HP:0010990)4.48150723
15Abnormality of glutamine family amino acid metabolism (HP:0010902)4.38753520
16Epidermoid cyst (HP:0200040)4.36345104
17Hyperglycinemia (HP:0002154)4.32850526
18Hypoalphalipoproteinemia (HP:0003233)4.27183235
19Abnormality of sulfur amino acid metabolism (HP:0004339)4.26048948
20Fat malabsorption (HP:0002630)4.21690763
21Abnormality of aspartate family amino acid metabolism (HP:0010899)4.14447659
22Abnormality of methionine metabolism (HP:0010901)4.13647136
23Ketosis (HP:0001946)4.10323878
24Hyperglycinuria (HP:0003108)4.00069818
25Hypoglycemic coma (HP:0001325)3.97347321
26Abnormality of glycine metabolism (HP:0010895)3.93957965
27Abnormality of serine family amino acid metabolism (HP:0010894)3.93957965
28Abnormality of complement system (HP:0005339)3.85630697
29Abnormality of the intrinsic pathway (HP:0010989)3.77501355
30Abnormality of pyrimidine metabolism (HP:0004353)3.76723333
31Conjugated hyperbilirubinemia (HP:0002908)3.74267099
32Hypercholesterolemia (HP:0003124)3.59954952
33Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.36747587
34Abnormality of fatty-acid metabolism (HP:0004359)3.36033807
35Hyperbilirubinemia (HP:0002904)3.34590858
36Osteomalacia (HP:0002749)3.23857511
37Spontaneous abortion (HP:0005268)3.12753701
38Steatorrhea (HP:0002570)3.07602640
39Abnormality of nucleobase metabolism (HP:0010932)3.02596351
40Abnormality of serum amino acid levels (HP:0003112)3.00935351
41Delayed CNS myelination (HP:0002188)2.95518557
42Hypochromic microcytic anemia (HP:0004840)2.95138003
43Hepatocellular carcinoma (HP:0001402)2.94477806
44Ketoacidosis (HP:0001993)2.92210060
45Acanthocytosis (HP:0001927)2.89548572
46Nephritis (HP:0000123)2.89493326
47Hyperphosphaturia (HP:0003109)2.81897026
48Metabolic acidosis (HP:0001942)2.79734541
49Myocardial infarction (HP:0001658)2.79468994
50Systemic lupus erythematosus (HP:0002725)2.70394396
51Skin nodule (HP:0200036)2.67336818
52Abnormality of purine metabolism (HP:0004352)2.65532860
53Nausea (HP:0002018)2.64454845
54Dicarboxylic aciduria (HP:0003215)2.61272064
55Abnormality of dicarboxylic acid metabolism (HP:0010995)2.61272064
56Lethargy (HP:0001254)2.61168700
57Cholecystitis (HP:0001082)2.59326265
58Abnormal gallbladder physiology (HP:0012438)2.59326265
59Hypoglycemic seizures (HP:0002173)2.53275871
60Vascular calcification (HP:0004934)2.52179147
61Abnormal gallbladder morphology (HP:0012437)2.51787123
62Malnutrition (HP:0004395)2.51451800
63Abnormal urine phosphate concentration (HP:0012599)2.48417601
64Cholelithiasis (HP:0001081)2.47275890
65Amyloidosis (HP:0011034)2.44911813
66Pigmentary retinal degeneration (HP:0001146)2.41759174
67Cerebral edema (HP:0002181)2.40943346
68Spastic diplegia (HP:0001264)2.40201331
69Glomerulonephritis (HP:0000099)2.39533662
70Gout (HP:0001997)2.35043244
71Reduced antithrombin III activity (HP:0001976)2.33654027
72Recurrent gram-negative bacterial infections (HP:0005420)2.31886039
73Irritability (HP:0000737)2.30728577
74Neonatal onset (HP:0003623)2.27098117
75Cardiovascular calcification (HP:0011915)2.22693010
76Gingival bleeding (HP:0000225)2.22633044
77Esophageal varix (HP:0002040)2.21911117
78Mitral stenosis (HP:0001718)2.21692760
79Poikilocytosis (HP:0004447)2.21238944
80Retinal atrophy (HP:0001105)2.20449054
81Sensorimotor neuropathy (HP:0007141)2.19651257
82Pancreatitis (HP:0001733)2.18572658
83Late onset (HP:0003584)2.13099216
84Widely patent fontanelles and sutures (HP:0004492)2.09993819
85Menorrhagia (HP:0000132)2.09563090
86Thrombophlebitis (HP:0004418)2.09214361
87Hydroxyprolinuria (HP:0003080)2.08341779
88Abnormality of proline metabolism (HP:0010907)2.08341779
89Vomiting (HP:0002013)2.07897150
90Abnormality of alkaline phosphatase activity (HP:0004379)2.07805880
91Brushfield spots (HP:0001088)2.07576678
92Generalized aminoaciduria (HP:0002909)2.06783024
93Enlarged kidneys (HP:0000105)2.06357567
94Elevated alkaline phosphatase (HP:0003155)2.06309181
95Abnormality of the gallbladder (HP:0005264)2.05208269
96Hyperinsulinemic hypoglycemia (HP:0000825)2.05118366
97Abnormality of the vitamin B12 metabolism (HP:0004341)2.03561497
98Abnormal tarsal ossification (HP:0008369)2.03286994
99Joint swelling (HP:0001386)2.00586734
100Abnormality of vitamin B metabolism (HP:0004340)1.99403678
101Hemorrhage of the eye (HP:0011885)1.98495737
102Opisthotonus (HP:0002179)1.96804112
103Abnormality of transition element cation homeostasis (HP:0011030)1.93039373
104Abnormality of iron homeostasis (HP:0011031)1.92562650
105Rickets (HP:0002748)1.91567810
106Abnormality of vitamin metabolism (HP:0100508)1.91389744
107Nephrolithiasis (HP:0000787)1.90032467
108Abnormal cartilage morphology (HP:0002763)1.89417463
109Alkalosis (HP:0001948)1.88513811
110Hypophosphatemia (HP:0002148)1.88396230
111Facial shape deformation (HP:0011334)1.87807515
112Potter facies (HP:0002009)1.87807515
113Glycosuria (HP:0003076)1.82828699
114Abnormality of urine glucose concentration (HP:0011016)1.82828699
115Renal cortical cysts (HP:0000803)1.81516600
116Confusion (HP:0001289)1.80236524
117Purpura (HP:0000979)1.80079143
118Hypophosphatemic rickets (HP:0004912)1.80008963
119Reticulocytosis (HP:0001923)1.79979958
120Arthropathy (HP:0003040)1.79780478
121Abnormal enzyme/coenzyme activity (HP:0012379)1.78941436
122Proximal tubulopathy (HP:0000114)1.78895705
123Elevated hepatic transaminases (HP:0002910)1.77872297
124Abnormality of the Achilles tendon (HP:0005109)1.75655323
125Pulmonary embolism (HP:0002204)1.71884626
126Megaloblastic anemia (HP:0001889)1.71502746
127Cerebral palsy (HP:0100021)1.70921946
128Ileus (HP:0002595)1.68283573

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK7.15179017
2ACVR1B6.55536085
3PDK25.05847783
4ERN14.66815112
5FGFR44.58455002
6SIK14.05902300
7TAOK33.08180171
8ERBB42.96716415
9MAP3K122.73147874
10INSRR2.66466847
11MST1R2.52332348
12MAP2K42.12838226
13PKN22.11693153
14FRK2.09127087
15MAPK111.91497070
16MUSK1.91010630
17LATS11.87730382
18TYK21.80387348
19FLT31.76313299
20TRIB31.71806857
21PIK3CG1.69854667
22PTK61.66369053
23PIK3CA1.60291350
24NEK91.54475015
25LMTK21.54001570
26ABL21.52170637
27TNIK1.45018589
28GRK61.44512836
29DAPK21.38968284
30STK391.34406203
31KDR1.30543861
32MYLK1.24225255
33NLK1.22586456
34MAP3K101.17311048
35MAP3K71.16647787
36JAK21.14706352
37PRKAA21.10762980
38TBK11.10150064
39MAP3K31.08129588
40FGFR21.05174381
41MET1.04851508
42ERBB21.04040329
43MAP3K111.03840466
44PINK11.03779514
45MAP2K31.03151743
46STK38L0.97053891
47MAP3K140.96837713
48OXSR10.95102251
49EPHB10.90610244
50MAPK40.88808710
51CASK0.87295425
52JAK10.86791781
53MAP2K60.85784854
54PRKCZ0.85735321
55CDK60.82584039
56RIPK10.81665590
57NTRK30.78282397
58MAPK150.74163263
59BCR0.74123589
60PRKACG0.72952334
61CAMK2G0.72837318
62PTK20.71250344
63DYRK1B0.69961695
64PRKG10.68114909
65EPHA30.67547056
66WNK30.66165462
67TIE10.66044390
68CSK0.64123647
69GSK3A0.64060257
70PRKAA10.63924612
71MAPK120.63549323
72PDGFRA0.63268194
73MAP2K20.62405320
74RPS6KB10.60896474
75MAP2K10.60342318
76TAOK20.59183994
77PRKCB0.58479477
78EIF2AK30.57554328
79PRKACA0.56292262
80NEK60.56264906
81PBK0.55543412
82IRAK30.55181179
83FER0.54304268
84FGFR10.53521395
85STK160.52337412
86IKBKE0.51747839
87PDPK10.51438845
88PRKCQ0.50394773
89CDK40.49948864
90SGK30.47576086
91MAP3K50.47407378
92CAMK1D0.47078372
93GRK10.46669229
94NEK10.46626425
95CAMK2D0.45526934
96PRKACB0.45398464
97PRKCE0.45254342
98MAP3K20.44408723
99SRC0.43579624
100CSNK1G10.43281955
101TRIM280.43058809
102MATK0.42987023
103CSF1R0.42794094
104CSNK1A10.42762045
105EPHB20.41277246
106MAPK70.40542192
107TGFBR20.40444691
108FGFR30.40398408
109CDK90.39754692
110MAP3K130.39029675
111KSR20.38816911
112MAP3K60.38560075
113MAPKAPK30.37978233
114MAP3K10.36925173
115IGF1R0.36420070
116ICK0.36087502
117CSNK2A10.35251682
118RET0.34989268
119DAPK30.34380913
120CSNK2A20.34367012
121CSNK1D0.34277571
122LATS20.33433232
123EIF2AK10.32184546
124EPHA20.32047683
125EGFR0.31570050
126CSNK1E0.31409200
127MTOR0.31345114
128TESK20.31193779
129PRKCG0.30445181
130AKT30.30304456
131NUAK10.29888652
132PRKG20.28826991
133PRKCA0.27743529
134PDK10.27731818
135PAK30.27007672
136SGK20.26766486
137BMX0.22721678
138EPHA40.22580971
139CAMK40.22311808
140SGK4940.21499229
141SGK2230.21499229
142STK30.20663480

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.41707177
2Nitrogen metabolism_Homo sapiens_hsa009103.55028034
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.35772872
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.26768514
5Arginine biosynthesis_Homo sapiens_hsa002203.07049425
6Complement and coagulation cascades_Homo sapiens_hsa046102.76559484
7Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.64837152
8Tryptophan metabolism_Homo sapiens_hsa003802.64708211
9Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.57045130
10Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.54139384
11Fatty acid degradation_Homo sapiens_hsa000712.48545795
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.36553250
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.22964745
14Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.16640177
15Butanoate metabolism_Homo sapiens_hsa006502.14378249
16Peroxisome_Homo sapiens_hsa041462.04038189
17Chemical carcinogenesis_Homo sapiens_hsa052041.96755672
18Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.94019321
19Histidine metabolism_Homo sapiens_hsa003401.93643014
20PPAR signaling pathway_Homo sapiens_hsa033201.88447468
21Steroid hormone biosynthesis_Homo sapiens_hsa001401.88281124
22Propanoate metabolism_Homo sapiens_hsa006401.86821366
23Fatty acid metabolism_Homo sapiens_hsa012121.76261806
24Drug metabolism - other enzymes_Homo sapiens_hsa009831.74272494
25Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.73900043
26Caffeine metabolism_Homo sapiens_hsa002321.73277414
27Staphylococcus aureus infection_Homo sapiens_hsa051501.69382348
28Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.69093161
29Retinol metabolism_Homo sapiens_hsa008301.68589374
30beta-Alanine metabolism_Homo sapiens_hsa004101.67748003
31Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.62280826
32Selenocompound metabolism_Homo sapiens_hsa004501.56853812
332-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.53857726
34Phenylalanine metabolism_Homo sapiens_hsa003601.52458568
35Bile secretion_Homo sapiens_hsa049761.52362254
36Sulfur metabolism_Homo sapiens_hsa009201.50660641
37Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.47234653
38Tyrosine metabolism_Homo sapiens_hsa003501.41763235
39Pyruvate metabolism_Homo sapiens_hsa006201.36996026
40Starch and sucrose metabolism_Homo sapiens_hsa005001.34763759
41* Fat digestion and absorption_Homo sapiens_hsa049751.33760891
42Cysteine and methionine metabolism_Homo sapiens_hsa002701.32574073
43Fatty acid elongation_Homo sapiens_hsa000621.31784945
44Folate biosynthesis_Homo sapiens_hsa007901.31725124
45Biosynthesis of amino acids_Homo sapiens_hsa012301.22840061
46Steroid biosynthesis_Homo sapiens_hsa001001.22145598
47Carbon metabolism_Homo sapiens_hsa012001.18032540
48ABC transporters_Homo sapiens_hsa020101.14891840
49Vitamin digestion and absorption_Homo sapiens_hsa049771.09273710
50Maturity onset diabetes of the young_Homo sapiens_hsa049501.08683319
51Cyanoamino acid metabolism_Homo sapiens_hsa004601.04967544
52Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.01568319
53Arginine and proline metabolism_Homo sapiens_hsa003301.01229930
54Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.00852792
55Sulfur relay system_Homo sapiens_hsa041221.00648807
56Vitamin B6 metabolism_Homo sapiens_hsa007500.95722676
57Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.91797302
58Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.85800369
59Lysine degradation_Homo sapiens_hsa003100.78194597
60Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.77552705
61Glutathione metabolism_Homo sapiens_hsa004800.76921571
62One carbon pool by folate_Homo sapiens_hsa006700.76737432
63Glycerolipid metabolism_Homo sapiens_hsa005610.71464564
64Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.67697704
65Pentose phosphate pathway_Homo sapiens_hsa000300.66961961
66Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.51932657
67Fatty acid biosynthesis_Homo sapiens_hsa000610.48950495
68* Metabolic pathways_Homo sapiens_hsa011000.47607891
69Galactose metabolism_Homo sapiens_hsa000520.41373621
70Fructose and mannose metabolism_Homo sapiens_hsa000510.39102829
71Other glycan degradation_Homo sapiens_hsa005110.38971959
72Prion diseases_Homo sapiens_hsa050200.36807315
73Sphingolipid metabolism_Homo sapiens_hsa006000.33786134
74Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.25645328
75Insulin resistance_Homo sapiens_hsa049310.19796207
76Adipocytokine signaling pathway_Homo sapiens_hsa049200.17447754
77* Glycerophospholipid metabolism_Homo sapiens_hsa005640.11564111
78Pertussis_Homo sapiens_hsa051330.06102042
79Glucagon signaling pathway_Homo sapiens_hsa049220.05146950
80Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.04987842
81Renin-angiotensin system_Homo sapiens_hsa046140.01503051
82* alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.00671045
83* Arachidonic acid metabolism_Homo sapiens_hsa00590-0.2641697
84Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.2363814
85Amoebiasis_Homo sapiens_hsa05146-0.2303128
86Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512-0.2221360
87Protein digestion and absorption_Homo sapiens_hsa04974-0.2105920
88Bladder cancer_Homo sapiens_hsa05219-0.2086103
89Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1973160
90Regulation of autophagy_Homo sapiens_hsa04140-0.1700217
91Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.1672530
92Hepatitis C_Homo sapiens_hsa05160-0.1593749
93Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1541110
94Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1444720
95Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.1393977
96Systemic lupus erythematosus_Homo sapiens_hsa05322-0.1234977
97Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.1227633
98African trypanosomiasis_Homo sapiens_hsa05143-0.1226722
99* Ether lipid metabolism_Homo sapiens_hsa00565-0.1222212
100Insulin signaling pathway_Homo sapiens_hsa04910-0.1221179
101Mineral absorption_Homo sapiens_hsa04978-0.0955613
102Serotonergic synapse_Homo sapiens_hsa04726-0.0852252
103Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601-0.0815912
104Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0786930
105* Linoleic acid metabolism_Homo sapiens_hsa00591-0.0322288
106N-Glycan biosynthesis_Homo sapiens_hsa00510-0.0270738
107Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0084932
108AMPK signaling pathway_Homo sapiens_hsa04152-0.0065218

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