PLA2G15

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Lysophospholipases are enzymes that act on biological membranes to regulate the multifunctional lysophospholipids. The protein encoded by this gene hydrolyzes lysophosphatidylcholine to glycerophosphorylcholine and a free fatty acid. This enzyme is present in the plasma and thought to be associated with high-density lipoprotein. A later paper contradicts the function of this gene. It demonstrates that this gene encodes a lysosomal enzyme instead of a lysophospholipase and has both calcium-independent phospholipase A2 and transacylase activities. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1modulation by organism of immune response of other organism involved in symbiotic interaction (GO:006.68564962
2modulation by organism of defense response of other organism involved in symbiotic interaction (GO:06.68564962
3positive regulation by organism of defense response of other organism involved in symbiotic interact6.68564962
4modulation by symbiont of host immune response (GO:0052553)6.68564962
5positive regulation by symbiont of host defense response (GO:0052509)6.68564962
6modulation by symbiont of host defense response (GO:0052031)6.68564962
7regulation of interferon-beta biosynthetic process (GO:0045357)6.20664424
8mannose metabolic process (GO:0006013)5.91134241
9macrophage activation involved in immune response (GO:0002281)5.63169640
10microglial cell activation (GO:0001774)5.41567418
11negative regulation of granulocyte differentiation (GO:0030853)4.75102637
12positive regulation of interleukin-8 biosynthetic process (GO:0045416)4.72037236
13regulation of antigen processing and presentation of peptide antigen (GO:0002583)4.28564589
14keratan sulfate catabolic process (GO:0042340)4.22061525
15apoptotic cell clearance (GO:0043277)4.20496378
16barbed-end actin filament capping (GO:0051016)4.16050642
17adhesion of symbiont to host cell (GO:0044650)4.12875688
18virion attachment to host cell (GO:0019062)4.12875688
19antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.12858559
20positive regulation of interferon-alpha production (GO:0032727)4.06905426
21immunoglobulin mediated immune response (GO:0016064)4.00432043
22positive regulation of chemokine secretion (GO:0090197)3.98144246
23response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.96994501
24response to host immune response (GO:0052572)3.96994501
25macrophage activation (GO:0042116)3.93711764
26folic acid transport (GO:0015884)3.93020782
27glycosphingolipid catabolic process (GO:0046479)3.83677704
28regulation of interferon-alpha production (GO:0032647)3.83164563
29response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.78097089
30response to host (GO:0075136)3.78097089
31response to host defenses (GO:0052200)3.78097089
32pinocytosis (GO:0006907)3.71793734
33response to acidic pH (GO:0010447)3.63669199
34adhesion of symbiont to host (GO:0044406)3.59201289
35hyaluronan catabolic process (GO:0030214)3.55917230
36phagosome maturation (GO:0090382)3.53061270
37folic acid metabolic process (GO:0046655)3.44695746
38negative regulation of mast cell activation (GO:0033004)3.43136505
39glycolipid catabolic process (GO:0019377)3.40712925
40regulation of B cell receptor signaling pathway (GO:0050855)3.39095232
41positive regulation of myeloid leukocyte mediated immunity (GO:0002888)3.36630306
42regulation of cholesterol storage (GO:0010885)3.34799547
43positive regulation of antigen processing and presentation (GO:0002579)3.33668894
44positive regulation of mast cell degranulation (GO:0043306)3.31382590
45positive regulation of mast cell activation involved in immune response (GO:0033008)3.31382590
46positive regulation of B cell differentiation (GO:0045579)3.29719928
47cellular response to cadmium ion (GO:0071276)3.25542210
48positive regulation of leukocyte degranulation (GO:0043302)3.25217937
49negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.22431871
50vitamin transmembrane transport (GO:0035461)3.21199444
51positive regulation of interferon-beta production (GO:0032728)3.21169655
52cellular response to zinc ion (GO:0071294)3.18761743
53positive regulation of SMAD protein import into nucleus (GO:0060391)3.14532490
54response to xenobiotic stimulus (GO:0009410)3.13409056
55energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.13345422
56ATP hydrolysis coupled proton transport (GO:0015991)3.13345422
57neutrophil activation involved in immune response (GO:0002283)3.13137801
58adenosine receptor signaling pathway (GO:0001973)3.11957047
59transferrin transport (GO:0033572)3.08936328
60response to pH (GO:0009268)3.08643188
61negative regulation of macrophage differentiation (GO:0045650)3.07973478
62amino sugar catabolic process (GO:0046348)3.07567449
63negative regulation of nitric-oxide synthase activity (GO:0051001)3.06161878
64cellular extravasation (GO:0045123)3.04562736
65negative regulation of interleukin-12 production (GO:0032695)3.01782203
66low-density lipoprotein particle clearance (GO:0034383)2.99339469
67negative regulation of interleukin-6 production (GO:0032715)2.96313813
68regulation of interleukin-8 biosynthetic process (GO:0045414)2.95791604
69regulation of mast cell activation involved in immune response (GO:0033006)2.94988889
70ganglioside metabolic process (GO:0001573)2.93169752
71positive regulation of mast cell activation (GO:0033005)2.92992252
72ceramide catabolic process (GO:0046514)2.92749125
73negative regulation of interleukin-1 production (GO:0032692)2.91938477
74regulation of macrophage chemotaxis (GO:0010758)2.91130052
75negative regulation of nitric oxide biosynthetic process (GO:0045019)2.90126464
76B cell mediated immunity (GO:0019724)2.90089798
77antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.89195255
78antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.89195255
79regulation of SMAD protein import into nucleus (GO:0060390)2.88270858
80cellular response to arsenic-containing substance (GO:0071243)2.88152685
81macrophage differentiation (GO:0030225)2.85307580
82trivalent inorganic cation transport (GO:0072512)2.85078779
83ferric iron transport (GO:0015682)2.85078779
84interferon-gamma secretion (GO:0072643)2.84597437
85glycosphingolipid metabolic process (GO:0006687)2.84298413
86myeloid cell activation involved in immune response (GO:0002275)2.84160692
87response to peptidoglycan (GO:0032494)2.83111706
88regulation of mast cell activation (GO:0033003)2.82443749
89peptidyl-glutamic acid carboxylation (GO:0017187)2.82248332
90protein carboxylation (GO:0018214)2.82248332
91regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.81234891
92intracellular pH reduction (GO:0051452)2.80912045
93Arp2/3 complex-mediated actin nucleation (GO:0034314)2.80706091
94respiratory burst (GO:0045730)2.80415735
95regulation of antigen processing and presentation (GO:0002577)2.79879669
96alanine transport (GO:0032328)2.79064925
97decidualization (GO:0046697)2.78221453
98eosinophil chemotaxis (GO:0048245)2.78194460
99production of molecular mediator involved in inflammatory response (GO:0002532)2.75170857
100pH reduction (GO:0045851)2.75158497
101regulation of interferon-beta production (GO:0032648)2.74918268
102cellular response to thyroid hormone stimulus (GO:0097067)2.72554073
103purine nucleobase biosynthetic process (GO:0009113)2.72037642
104G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.70562734
105glycosylceramide metabolic process (GO:0006677)2.70502191
106chondroitin sulfate catabolic process (GO:0030207)2.70263861
107negative regulation of interleukin-1 beta production (GO:0032691)2.70121414
108regulation of myeloid leukocyte mediated immunity (GO:0002886)2.70120090
109positive regulation of triglyceride biosynthetic process (GO:0010867)2.70082415
110regulation of chemokine secretion (GO:0090196)2.68616218
111endosome to melanosome transport (GO:0035646)2.66288903
112endosome to pigment granule transport (GO:0043485)2.66288903
113cyclooxygenase pathway (GO:0019371)2.64772818
114regulation of leukocyte degranulation (GO:0043300)2.64642153
115autophagic vacuole assembly (GO:0000045)2.64481948
116fucose metabolic process (GO:0006004)2.62854481
117oligosaccharide catabolic process (GO:0009313)2.62565255
118response to magnesium ion (GO:0032026)2.61332796
119sphingolipid catabolic process (GO:0030149)2.59753772
120pantothenate metabolic process (GO:0015939)2.58509153
121regulation of early endosome to late endosome transport (GO:2000641)2.56575441
122glucosamine-containing compound catabolic process (GO:1901072)2.55751633
123epithelial cell differentiation involved in prostate gland development (GO:0060742)2.55186021
124complement activation, classical pathway (GO:0006958)2.54235845
125response to thyroid hormone (GO:0097066)2.53022180
126complement activation (GO:0006956)2.52851106
127regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.52522359
128negative regulation of platelet activation (GO:0010544)2.52294404
129complement activation, alternative pathway (GO:0006957)2.51370365
130modified amino acid transport (GO:0072337)2.51340062
131regulation of phagocytosis (GO:0050764)2.51165291
132cofactor catabolic process (GO:0051187)2.50683626
133N-acetylneuraminate metabolic process (GO:0006054)2.50514208
134regulation of autophagic vacuole assembly (GO:2000785)2.50393597
135negative regulation of protein autophosphorylation (GO:0031953)2.49333652
136plasma lipoprotein particle clearance (GO:0034381)2.49328412
137positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.49057349
138response to laminar fluid shear stress (GO:0034616)2.48367589
139cellular response to pH (GO:0071467)2.48218572
140regulation of mononuclear cell migration (GO:0071675)2.48155072
141cellular iron ion homeostasis (GO:0006879)2.47555489
142basic amino acid transport (GO:0015802)2.46461491
143detection of molecule of bacterial origin (GO:0032490)2.45927158
144eosinophil migration (GO:0072677)2.45887171
145I-kappaB phosphorylation (GO:0007252)2.45706762
146positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.45661539
147antigen processing and presentation of endogenous antigen (GO:0019883)2.45017686
148regulation of integrin activation (GO:0033623)2.44594199
149activation of protein kinase B activity (GO:0032148)2.44005122
150chaperone mediated protein folding requiring cofactor (GO:0051085)2.43162904
151vacuole organization (GO:0007033)2.42588986
152substrate-dependent cell migration (GO:0006929)2.42234512
153regulation of mast cell degranulation (GO:0043304)2.41731966
154sphingosine metabolic process (GO:0006670)2.39749395
155L-alpha-amino acid transmembrane transport (GO:1902475)2.38259334
156positive regulation of calcium-mediated signaling (GO:0050850)2.37911660
157serine transport (GO:0032329)2.36668955
158monocyte chemotaxis (GO:0002548)2.36625587
159response to muscle activity (GO:0014850)2.36579553
160nitric oxide biosynthetic process (GO:0006809)2.36359000
161membrane lipid catabolic process (GO:0046466)2.36178572
162positive regulation of phagocytosis (GO:0050766)2.36020161
163lytic vacuole organization (GO:0080171)2.35530617
164lysosome organization (GO:0007040)2.35530617
165regulation of chemokine-mediated signaling pathway (GO:0070099)2.35355456
166phagocytosis, recognition (GO:0006910)2.33099421
167positive regulation of monocyte chemotaxis (GO:0090026)2.32779377
168regulation of membrane protein ectodomain proteolysis (GO:0051043)2.32063638
169iron ion transport (GO:0006826)2.30601116
170autophagic vacuole fusion (GO:0000046)2.28919545
171glial cell migration (GO:0008347)2.28797841

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_21731497_ChIP-ChIP_J774_Mouse3.97845627
2EGR1_19374776_ChIP-ChIP_THP-1_Human3.09578966
3NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human3.08314108
4IRF8_27001747_Chip-Seq_BMDM_Mouse2.93094590
5SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.77386341
6LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.59916464
7NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.53696696
8PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.46733980
9NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.43968991
10IRF8_22096565_ChIP-ChIP_GC-B_Human2.41202111
11MYB_21317192_ChIP-Seq_ERMYB_Mouse2.39758788
12BP1_19119308_ChIP-ChIP_Hs578T_Human2.23036151
13* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.22213773
14ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.20688328
15VDR_21846776_ChIP-Seq_THP-1_Human2.05784088
16* FOXM1_23109430_ChIP-Seq_U2OS_Human2.04923822
17TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.97738907
18MYC_22102868_ChIP-Seq_BL_Human1.95067333
19CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.93741773
20EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.91512283
21SPI1_23547873_ChIP-Seq_NB4_Human1.90491933
22* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.88844159
23Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.84667637
24PPARA_22158963_ChIP-Seq_LIVER_Mouse1.84588324
25CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.83861122
26VDR_24787735_ChIP-Seq_THP-1_Human1.83406571
27LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.82429963
28RXR_22158963_ChIP-Seq_LIVER_Mouse1.80254999
29CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.78424090
30ELK3_25401928_ChIP-Seq_HUVEC_Human1.73840605
31PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.68802748
32IKZF1_21737484_ChIP-ChIP_HCT116_Human1.65269368
33GATA2_21666600_ChIP-Seq_HMVEC_Human1.65049850
34CLOCK_20551151_ChIP-Seq_293T_Human1.64459406
35ELF1_20517297_ChIP-Seq_JURKAT_Human1.63951287
36BCL6_27268052_Chip-Seq_Bcells_Human1.63607991
37SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.61963407
38TFEB_21752829_ChIP-Seq_HELA_Human1.54562644
39POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.52599486
40* SPI1_23127762_ChIP-Seq_K562_Human1.51650494
41JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.51299839
42SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.49128684
43VDR_24763502_ChIP-Seq_THP-1_Human1.48672673
44PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.48278573
45RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.48084052
46* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.47890150
47THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.45529216
48E2F7_22180533_ChIP-Seq_HELA_Human1.45400433
49ZNF263_19887448_ChIP-Seq_K562_Human1.45115546
50RUNX1_22412390_ChIP-Seq_EML_Mouse1.43008727
51STAT3_1855785_ChIP-Seq_MESCs_Mouse1.42051480
52VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.41279761
53ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.40379446
54STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.40042940
55* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.39916753
56TCF7_22412390_ChIP-Seq_EML_Mouse1.39708322
57TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.38664936
58TP53_22127205_ChIP-Seq_IMR90_Human1.36992814
59CTCF_20526341_ChIP-Seq_ESCs_Human1.36009495
60STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.34628427
61TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.34600927
62* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.32654437
63MAF_26560356_Chip-Seq_TH1_Human1.32631684
64ZNF274_21170338_ChIP-Seq_K562_Hela1.32300091
65LXR_22158963_ChIP-Seq_LIVER_Mouse1.32280610
66RARG_19884340_ChIP-ChIP_MEFs_Mouse1.30348741
67SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.30196639
68SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.29581883
69JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.28899636
70SCL_19346495_ChIP-Seq_HPC-7_Human1.28254431
71ERA_21632823_ChIP-Seq_H3396_Human1.27731257
72LXR_22292898_ChIP-Seq_THP-1_Human1.27072467
73KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.25641598
74* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.24056165
75TET1_21451524_ChIP-Seq_MESCs_Mouse1.23545829
76PHF8_20622854_ChIP-Seq_HELA_Human1.22767965
77P68_20966046_ChIP-Seq_HELA_Human1.22417360
78* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.22297730
79CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.22036010
80RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.21996899
81CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.21316367
82SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.20906415
83RAC3_21632823_ChIP-Seq_H3396_Human1.20830681
84KDM2B_26808549_Chip-Seq_SUP-B15_Human1.19957376
85EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.18322252
86E2F1_20622854_ChIP-Seq_HELA_Human1.18291824
87NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.17343897
88GATA1_22025678_ChIP-Seq_K562_Human1.17227611
89STAT1_20625510_ChIP-Seq_HELA_Human1.16963895
90* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.15831369
91KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.15538498
92OCT4_20526341_ChIP-Seq_ESCs_Human1.15457575
93TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.15299915
94SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.15118654
95ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.14980446
96RAD21_21589869_ChIP-Seq_MESCs_Mouse1.14766802
97SPI1_20517297_ChIP-Seq_HL60_Human1.13837347
98ESR2_21235772_ChIP-Seq_MCF-7_Human1.12395401
99ATF3_27146783_Chip-Seq_COLON_Human1.10500221
100SA1_27219007_Chip-Seq_Bcells_Human1.10319286
101UTX_26944678_Chip-Seq_JUKART_Human1.10108906
102GATA1_22383799_ChIP-Seq_G1ME_Mouse1.09885044
103KLF4_18555785_ChIP-Seq_MESCs_Mouse1.09111285
104SRY_22984422_ChIP-ChIP_TESTIS_Rat1.08320741
105* KDM2B_26808549_Chip-Seq_DND41_Human1.08178269
106TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.07470717
107PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.05146646
108CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.05065844
109PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.04969317
110NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.04600486
111MYB_26560356_Chip-Seq_TH1_Human1.04286393
112IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.03900472
113PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.03608575
114GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03480279
115RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.03376258
116BCOR_27268052_Chip-Seq_Bcells_Human1.03243835
117GATA1_19941827_ChIP-Seq_MEL_Mouse1.02693116
118FOXH1_21741376_ChIP-Seq_ESCs_Human1.02444252
119GATA2_22383799_ChIP-Seq_G1ME_Mouse1.02348340
120SRF_21415370_ChIP-Seq_HL-1_Mouse1.01817204
121RACK7_27058665_Chip-Seq_MCF-7_Human1.01521195
122ETS1_20019798_ChIP-Seq_JURKAT_Human1.01447391
123CTCF_18555785_ChIP-Seq_MESCs_Mouse1.01105372
124CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.00637508
125PU_27001747_Chip-Seq_BMDM_Mouse1.00358771
126SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.00133431
127SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.00026198
128KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.99660491
129KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.99294422
130ESR1_21235772_ChIP-Seq_MCF-7_Human0.99138895
131TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.99067291
132SMC3_22415368_ChIP-Seq_MEFs_Mouse0.98726754
133FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.98451389
134MITF_21258399_ChIP-Seq_MELANOMA_Human0.98329573
135CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.97617405
136MYC_19829295_ChIP-Seq_ESCs_Human0.97229857
137CREB1_15753290_ChIP-ChIP_HEK293T_Human0.97223196
138P63_26484246_Chip-Seq_KERATINOCYTES_Human0.97148818
139RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.96811770
140JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.95485486
141DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.94979880
142KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.94974397
143MYB_26560356_Chip-Seq_TH2_Human0.94803082
144NCOR1_26117541_ChIP-Seq_K562_Human0.94521705
145RARB_24833708_ChIP-Seq_LIVER_Mouse0.94294815
146TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.93869356
147AR_21909140_ChIP-Seq_LNCAP_Human0.93864937
148TAF2_19829295_ChIP-Seq_ESCs_Human0.93846936
149* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.93437850
150CTCF_26484167_Chip-Seq_Bcells_Mouse0.93166738
151NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.93103374
152NELFA_20434984_ChIP-Seq_ESCs_Mouse0.92940557
153CSB_26484114_Chip-Seq_FIBROBLAST_Human0.92758567
154EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.92756181
155GATA3_21878914_ChIP-Seq_MCF-7_Human0.92459224
156TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.91263172
157TP63_22573176_ChIP-Seq_HFKS_Human0.89635227

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005058_abnormal_lysosome_morphology5.89085321
2MP0003191_abnormal_cellular_cholesterol3.97196502
3* MP0009840_abnormal_foam_cell3.87804310
4MP0003806_abnormal_nucleotide_metabolis3.32496237
5MP0003172_abnormal_lysosome_physiology3.29547485
6MP0003303_peritoneal_inflammation3.13794190
7MP0006082_CNS_inflammation3.05238122
8MP0002837_dystrophic_cardiac_calcinosis2.94494522
9MP0005167_abnormal_blood-brain_barrier2.54637681
10MP0001835_abnormal_antigen_presentation2.50554039
11MP0003436_decreased_susceptibility_to2.33846504
12* MP0002419_abnormal_innate_immunity2.22178816
13MP0008438_abnormal_cutaneous_collagen2.21119232
14MP0003705_abnormal_hypodermis_morpholog2.20349488
15MP0005464_abnormal_platelet_physiology2.05882805
16MP0003195_calcinosis1.99164084
17MP0002254_reproductive_system_inflammat1.87864696
18MP0003693_abnormal_embryo_hatching1.85632983
19MP0003690_abnormal_glial_cell1.84801194
20MP0000749_muscle_degeneration1.82786104
21MP0001533_abnormal_skeleton_physiology1.75983488
22MP0010386_abnormal_urinary_bladder1.70961428
23MP0003566_abnormal_cell_adhesion1.68297017
24MP0005000_abnormal_immune_tolerance1.67734389
25* MP0002452_abnormal_antigen_presenting1.67501243
26MP0000604_amyloidosis1.65158924
27MP0004510_myositis1.64347465
28MP0000015_abnormal_ear_pigmentation1.63291887
29MP0003075_altered_response_to1.61912959
30MP0010307_abnormal_tumor_latency1.60635839
31MP0003329_amyloid_beta_deposits1.59996814
32MP0000465_gastrointestinal_hemorrhage1.58449110
33MP0009333_abnormal_splenocyte_physiolog1.56027376
34MP0005360_urolithiasis1.54332916
35MP0005025_abnormal_response_to1.52725867
36MP0006054_spinal_hemorrhage1.52427828
37MP0005670_abnormal_white_adipose1.47974921
38MP0009764_decreased_sensitivity_to1.47055622
39MP0002723_abnormal_immune_serum1.46139334
40MP0004185_abnormal_adipocyte_glucose1.45153915
41MP0009278_abnormal_bone_marrow1.44842427
42MP0000343_altered_response_to1.44520733
43MP0003724_increased_susceptibility_to1.43393972
44MP0008875_abnormal_xenobiotic_pharmacok1.43223506
45MP0001800_abnormal_humoral_immune1.42676667
46MP0008469_abnormal_protein_level1.41250676
47MP0005671_abnormal_response_to1.40551267
48MP0003300_gastrointestinal_ulcer1.39812389
49MP0005595_abnormal_vascular_smooth1.37886578
50MP0003646_muscle_fatigue1.36274672
51MP0001790_abnormal_immune_system1.35668371
52MP0005387_immune_system_phenotype1.35668371
53MP0010329_abnormal_lipoprotein_level1.31624629
54* MP0001819_abnormal_immune_cell1.31118027
55MP0005397_hematopoietic_system_phenotyp1.30703780
56MP0001545_abnormal_hematopoietic_system1.30703780
57MP0005165_increased_susceptibility_to1.30267942
58* MP0002420_abnormal_adaptive_immunity1.28475828
59* MP0000609_abnormal_liver_physiology1.28467998
60MP0001849_ear_inflammation1.27965894
61MP0002148_abnormal_hypersensitivity_rea1.27838404
62MP0003718_maternal_effect1.26832721
63* MP0000689_abnormal_spleen_morphology1.25324037
64MP0004947_skin_inflammation1.24940502
65MP0002295_abnormal_pulmonary_circulatio1.23228768
66MP0001845_abnormal_inflammatory_respons1.22979154
67MP0005310_abnormal_salivary_gland1.22855431
68MP0002396_abnormal_hematopoietic_system1.21989733
69MP0008260_abnormal_autophagy1.21962500
70MP0004130_abnormal_muscle_cell1.20904591
71MP0002405_respiratory_system_inflammati1.19544667
72MP0003879_abnormal_hair_cell1.18840645
73MP0008004_abnormal_stomach_pH1.14904986
74MP0003448_altered_tumor_morphology1.14370632
75MP0000747_muscle_weakness1.14162246
76MP0001542_abnormal_bone_strength1.13961717
77MP0005023_abnormal_wound_healing1.13931424
78MP0001756_abnormal_urination1.13804798
79MP0001851_eye_inflammation1.12633449
80MP0000569_abnormal_digit_pigmentation1.12563804
81MP0000685_abnormal_immune_system1.10777393
82MP0000751_myopathy1.09975839
83MP0005451_abnormal_body_composition1.07326725
84* MP0000716_abnormal_immune_system1.05761219
85MP0003183_abnormal_peptide_metabolism1.04805165
86MP0010352_gastrointestinal_tract_polyps1.04569436
87* MP0002722_abnormal_immune_system1.04415974
88MP0000598_abnormal_liver_morphology1.03780941
89MP0003828_pulmonary_edema1.00728814
90MP0005257_abnormal_intraocular_pressure1.00032347
91MP0005166_decreased_susceptibility_to0.99791289
92MP0003634_abnormal_glial_cell0.99790654
93MP0010368_abnormal_lymphatic_system0.99473695
94MP0003111_abnormal_nucleus_morphology0.98978895
95MP0003011_delayed_dark_adaptation0.98451181
96MP0003950_abnormal_plasma_membrane0.97457913
97MP0005174_abnormal_tail_pigmentation0.97360608
98MP0005330_cardiomyopathy0.95880067
99MP0005076_abnormal_cell_differentiation0.95559996
100* MP0002429_abnormal_blood_cell0.95445705
101MP0004019_abnormal_vitamin_homeostasis0.95404115
102MP0001915_intracranial_hemorrhage0.95297242
103MP0005365_abnormal_bile_salt0.95264244
104MP0002998_abnormal_bone_remodeling0.95205104
105MP0004782_abnormal_surfactant_physiolog0.94908629
106MP0004084_abnormal_cardiac_muscle0.94688208
107MP0003656_abnormal_erythrocyte_physiolo0.94305529
108MP0002398_abnormal_bone_marrow0.93863354
109MP0000538_abnormal_urinary_bladder0.93626611
110MP0002269_muscular_atrophy0.93463907
111MP0000920_abnormal_myelination0.92614088
112MP0000750_abnormal_muscle_regeneration0.92317651
113MP0009785_altered_susceptibility_to0.92312263
114MP0008007_abnormal_cellular_replicative0.91251712
115MP0003279_aneurysm0.90722843
116MP0005390_skeleton_phenotype0.89143465
117MP0003137_abnormal_impulse_conducting0.88841354
118MP0003633_abnormal_nervous_system0.88019385
119MP0000858_altered_metastatic_potential0.87581835
120MP0009643_abnormal_urine_homeostasis0.87505851
121MP0001853_heart_inflammation0.86922113
122MP0002136_abnormal_kidney_physiology0.86483027
123MP0000371_diluted_coat_color0.84650333
124MP0005666_abnormal_adipose_tissue0.84543900
125MP0001958_emphysema0.84365910
126MP0004036_abnormal_muscle_relaxation0.83856375
127MP0002090_abnormal_vision0.83633277
128MP0004883_abnormal_blood_vessel0.83179061
129MP0005319_abnormal_enzyme/_coenzyme0.83166113
130MP0003186_abnormal_redox_activity0.82034057
131MP0000490_abnormal_crypts_of0.80411172
132MP0004233_abnormal_muscle_weight0.80309898
133MP0009763_increased_sensitivity_to0.80195087
134MP0001986_abnormal_taste_sensitivity0.77818512
135MP0000767_abnormal_smooth_muscle0.77765593
136* MP0000249_abnormal_blood_vessel0.76811013
137MP0004272_abnormal_basement_membrane0.76727608
138MP0004808_abnormal_hematopoietic_stem0.76654303
139* MP0002118_abnormal_lipid_homeostasis0.76623884
140MP0008873_increased_physiological_sensi0.76207376
141MP0005410_abnormal_fertilization0.75300562
142MP0005395_other_phenotype0.74918701
143MP0005164_abnormal_response_to0.74623487
144MP0002139_abnormal_hepatobiliary_system0.74450499
145MP0003795_abnormal_bone_structure0.72235530
146MP0002896_abnormal_bone_mineralization0.72083667
147MP0002933_joint_inflammation0.70830350
148MP0002653_abnormal_ependyma_morphology0.70628761
149MP0002138_abnormal_hepatobiliary_system0.66761157
150MP0002229_neurodegeneration0.65913869
151MP0002972_abnormal_cardiac_muscle0.64629422

Predicted human phenotypes

RankGene SetZ-score
1Systemic lupus erythematosus (HP:0002725)7.51073497
2Abnormality of liposaccharide metabolism (HP:0010968)6.40688683
3Abnormality of glycosphingolipid metabolism (HP:0004343)6.40688683
4Abnormality of glycolipid metabolism (HP:0010969)6.40688683
5Glomerulonephritis (HP:0000099)5.77031296
6Increased cerebral lipofuscin (HP:0011813)5.75561219
7Dysostosis multiplex (HP:0000943)5.35855012
8Vacuolated lymphocytes (HP:0001922)5.12268646
9Complement deficiency (HP:0004431)5.03243197
10Increased neuronal autofluorescent lipopigment (HP:0002074)4.71474406
11Abnormality of complement system (HP:0005339)4.17186479
12Recurrent abscess formation (HP:0002722)4.10675999
13Urinary glycosaminoglycan excretion (HP:0003541)3.95494663
14Mucopolysacchariduria (HP:0008155)3.95494663
15Recurrent bacterial skin infections (HP:0005406)3.81342215
16Abnormality of polysaccharide metabolism (HP:0011012)3.73783870
17Abnormality of glycosaminoglycan metabolism (HP:0004371)3.73783870
18Abnormality of mucopolysaccharide metabolism (HP:0011020)3.73783870
19Cerebral aneurysm (HP:0004944)3.72552917
20Disinhibition (HP:0000734)3.68216680
21Nuclear cataract (HP:0100018)3.65590905
22Axonal loss (HP:0003447)3.58925174
23Mutism (HP:0002300)3.57745390
24Abnormality of macrophages (HP:0004311)3.41944223
25Eczematoid dermatitis (HP:0000976)3.41178073
26Recurrent gram-negative bacterial infections (HP:0005420)3.27599660
27Nephritis (HP:0000123)3.14609285
28Agnosia (HP:0010524)3.02802088
29Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.01346297
30Upper motor neuron abnormality (HP:0002127)2.99834714
31Loss of speech (HP:0002371)2.98768824
32Global brain atrophy (HP:0002283)2.97549410
33Pustule (HP:0200039)2.91543107
34Retinal atrophy (HP:0001105)2.86215639
35Personality changes (HP:0000751)2.82015643
36Purpura (HP:0000979)2.71807416
37Osteolytic defects of the phalanges of the hand (HP:0009771)2.69447914
38Osteolytic defects of the hand bones (HP:0009699)2.69447914
39Progressive neurologic deterioration (HP:0002344)2.69315984
40Myocardial infarction (HP:0001658)2.67163629
41Hematochezia (HP:0002573)2.61741887
42Hepatosplenomegaly (HP:0001433)2.61269351
43Inappropriate behavior (HP:0000719)2.56263943
44Arterial tortuosity (HP:0005116)2.53886896
45Thoracic kyphosis (HP:0002942)2.51709959
46Diminished motivation (HP:0000745)2.49400523
47Vertebral compression fractures (HP:0002953)2.46295306
48Apathy (HP:0000741)2.46096657
49Asymmetric septal hypertrophy (HP:0001670)2.44769441
50J-shaped sella turcica (HP:0002680)2.43936065
51Premature rupture of membranes (HP:0001788)2.37835974
52Neuronal loss in central nervous system (HP:0002529)2.36740221
53Cervical subluxation (HP:0003308)2.36403646
54Vascular tortuosity (HP:0004948)2.28127892
55Xanthomatosis (HP:0000991)2.25408661
56Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.24326271
57Clumsiness (HP:0002312)2.20611693
58Abnormality of the vasculature of the conjunctiva (HP:0008054)2.19976251
59Agitation (HP:0000713)2.16642451
60Joint stiffness (HP:0001387)2.16488339
61Conjunctival telangiectasia (HP:0000524)2.15190282
62Peripheral demyelination (HP:0011096)2.14946589
63Protuberant abdomen (HP:0001538)2.13209440
64Interstitial pulmonary disease (HP:0006530)2.13055684
65Polycythemia (HP:0001901)2.09470923
66Bone cyst (HP:0012062)2.07868423
67Recurrent skin infections (HP:0001581)2.07558545
68Pathologic fracture (HP:0002756)2.03709961
69Spondylolisthesis (HP:0003302)2.01834543
70Mesangial abnormality (HP:0001966)1.96240117
71Hyperlipoproteinemia (HP:0010980)1.95176327
72Neoplasm of head and neck (HP:0012288)1.94445881
73Esophageal neoplasm (HP:0100751)1.94445881
74Albinism (HP:0001022)1.94056596
75Opisthotonus (HP:0002179)1.93260057
76Mitral stenosis (HP:0001718)1.92803645
77Abnormality of the motor neurons (HP:0002450)1.92576080
78Abnormal neuron morphology (HP:0012757)1.92576080
79Progressive visual loss (HP:0000529)1.92263739
80Zonular cataract (HP:0010920)1.91886796
81Abnormality of the lumbar spine (HP:0100712)1.91882035
82Hand muscle atrophy (HP:0009130)1.91617844
83Spontaneous hematomas (HP:0007420)1.89147685
84Metaphyseal irregularity (HP:0003025)1.88623324
85Impaired platelet aggregation (HP:0003540)1.88014417
86Abnormal platelet function (HP:0011869)1.88014417
87Type II lissencephaly (HP:0007260)1.86863204
88Abnormality of the thoracic spine (HP:0100711)1.86661220
89Aortic aneurysm (HP:0004942)1.86155731
90Increased serum ferritin (HP:0003281)1.83999273
91Spinal rigidity (HP:0003306)1.83365316
92Ovoid vertebral bodies (HP:0003300)1.81260506
93Autoimmune thrombocytopenia (HP:0001973)1.81256389
94Cardiomegaly (HP:0001640)1.80515441
95Abnormality of lateral ventricle (HP:0030047)1.80403200
96Obstructive lung disease (HP:0006536)1.79687117
97Chronic obstructive pulmonary disease (HP:0006510)1.79687117
98Beaking of vertebral bodies (HP:0004568)1.78428091
99Basal ganglia calcification (HP:0002135)1.77410399
100Poor head control (HP:0002421)1.76726602
101Disproportionate tall stature (HP:0001519)1.76222751
102Striae distensae (HP:0001065)1.74992462
103Spinal muscular atrophy (HP:0007269)1.73863031
104Neurodegeneration (HP:0002180)1.73577626
105Joint hemorrhage (HP:0005261)1.73514860
106Aortic dissection (HP:0002647)1.73207536
107Ulnar deviation of the wrist (HP:0003049)1.72965776
108Increased CSF protein (HP:0002922)1.72559565
109Recurrent fungal infections (HP:0002841)1.71934573
110Abnormality of the distal phalanges of the toes (HP:0010182)1.71934356
111Gingivitis (HP:0000230)1.71350521
112Deep venous thrombosis (HP:0002625)1.68544491
113Colitis (HP:0002583)1.68291413
114Petechiae (HP:0000967)1.67661294
115Decreased electroretinogram (ERG) amplitude (HP:0000654)1.67513908
116Diaphragmatic weakness (HP:0009113)1.66720688
117Prolonged neonatal jaundice (HP:0006579)1.65890922
118Dementia (HP:0000726)1.64558980
119Hydroxyprolinuria (HP:0003080)1.64432441
120Abnormality of proline metabolism (HP:0010907)1.64432441
121Neurofibrillary tangles (HP:0002185)1.63767009
122Hypoalphalipoproteinemia (HP:0003233)1.63669262
123Hypoplasia of the odontoid process (HP:0003311)1.62937415
124Myoclonus (HP:0001336)1.62918331
125Achilles tendon contracture (HP:0001771)1.62815053
126Cerebral inclusion bodies (HP:0100314)1.61084283
127Polygenic inheritance (HP:0010982)1.60256069
128Amyloidosis (HP:0011034)1.59687107
129Myositis (HP:0100614)1.59250714
130Microretrognathia (HP:0000308)1.57192833
131Generalized amyotrophy (HP:0003700)1.57142248
132Long toe (HP:0010511)1.57121440
133Abnormality of iron homeostasis (HP:0011031)1.56214183
134Frequent falls (HP:0002359)1.55792000
135Supranuclear gaze palsy (HP:0000605)1.53340247
136Deformed sella turcica (HP:0002681)1.50607836
137Breast hypoplasia (HP:0003187)1.49923978
138Muscular dystrophy (HP:0003560)1.44838238
139Bulbar palsy (HP:0001283)1.43700956
140Distal lower limb muscle weakness (HP:0009053)1.43417850
141Abnormality of the vertebral endplates (HP:0005106)1.42851840
142Abnormality of transition element cation homeostasis (HP:0011030)1.42487170

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TGFBR25.04284973
2PINK13.88427694
3EPHA23.19352743
4ERN13.12006300
5BLK3.07271996
6TRIB33.03683360
7BUB12.98325761
8TYK22.71586213
9BMPR1B2.66729216
10ADRBK22.55449676
11CAMK1D2.46266026
12CSF1R2.37565389
13DAPK22.22877118
14MAP4K12.21011768
15PAK42.19839330
16CAMKK22.11376594
17TGFBR12.10325687
18TSSK62.10014631
19PKN21.96379630
20RIPK41.90588529
21STK101.80792335
22MYLK1.76669180
23IRAK31.74600191
24LIMK11.68472937
25SCYL21.67145716
26MAP2K31.64958880
27TBK11.64725832
28OBSCN1.59056953
29NEK21.57592161
30MAPK151.56791311
31KIT1.56358193
32EPHB21.53119676
33MAP2K61.48098583
34WEE11.47890944
35ARAF1.42510709
36TESK11.41322564
37EEF2K1.36958198
38ZAP701.33801891
39CAMK1G1.32629603
40PHKG21.29203194
41PHKG11.29203194
42RPS6KA41.25326131
43CAMKK11.21614692
44TIE11.18127758
45FRK1.17283499
46MAP3K11.16690282
47GRK71.15722266
48MOS1.13372514
49JAK11.12998944
50MAP3K31.12732686
51PRKG21.11506647
52PRKD21.11431774
53PIM21.07056878
54ADRBK11.06388762
55MAP3K91.04617392
56PTK2B1.04516878
57CSNK1G31.03255478
58TAOK31.03082020
59STK381.00703842
60FES0.99702874
61JAK20.99638802
62PAK60.98778144
63NEK90.94821814
64HCK0.94775071
65MAP3K80.93996217
66MAP3K110.90229650
67CSNK1A1L0.88507106
68EIF2AK10.86360156
69IKBKB0.83858777
70KSR20.83114513
71MAP2K20.83010843
72LRRK20.82919023
73CSNK1G20.80947850
74ABL20.80177340
75TLK10.77585304
76PTK60.77573648
77EPHB10.77311495
78FGFR40.76302466
79TRIM280.75992682
80CDC42BPA0.75761988
81CSK0.74990655
82RIPK10.74690068
83TTK0.73787296
84BRSK20.72908917
85DDR20.72709424
86PAK20.72164881
87PDK20.71155406
88IRAK40.70744402
89ACVR1B0.70484636
90TTN0.70394580
91ROCK10.67438910
92KDR0.67107755
93MATK0.62934511
94INSRR0.62797252
95LMTK20.62476655
96DAPK30.62359020
97CAMK10.59347170
98MAP2K70.58431825
99CAMK40.58147433
100STK30.58004058
101PDPK10.57630590
102SYK0.57489145
103PIM10.56825387
104CDK60.56509614
105LYN0.55788073
106CLK10.55482521
107TESK20.55403266
108ZAK0.55358908
109CDK40.54765523
110BCKDK0.53649724
111MAPKAPK30.53570193
112NME20.53339221
113TAOK20.52880141
114TAOK10.52794639
115PAK10.52270480
116CSNK1G10.51926319
117MAP3K130.51650761
118GRK10.51568827
119PDK10.51386860
120ALK0.51028177
121MAPK120.50732826
122FGR0.50382240
123PLK40.50245227
124MAP3K100.48680438
125JAK30.46997740
126MAP3K50.46982352
127AKT30.46937874
128GRK60.46087469
129LCK0.44822635
130CAMK2D0.44721637
131MAP3K60.44430923
132BTK0.44115166
133MAPK40.44042278
134PTK20.43799920
135MAP2K10.43672266
136PRKCQ0.42701232
137MAPKAPK20.41021698
138BRAF0.40492756
139RAF10.40114034
140MUSK0.37505849
141MARK30.36064351
142BMX0.35486484
143PRKD10.34991453
144EGFR0.34308523
145RPS6KA60.33765007
146RPS6KC10.33333544
147RPS6KL10.33333544
148MTOR0.32671171
149RPS6KA20.32434708
150PAK30.31551216
151PRKAA20.30601343
152SIK20.30306010
153SIK10.29987666
154PRKG10.29590890
155ABL10.28516731
156WNK40.27844487

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosaminoglycan degradation_Homo sapiens_hsa005314.97328207
2Staphylococcus aureus infection_Homo sapiens_hsa051504.89664909
3Other glycan degradation_Homo sapiens_hsa005114.65558630
4* Lysosome_Homo sapiens_hsa041424.20671334
5Vitamin B6 metabolism_Homo sapiens_hsa007503.00899565
6Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.73784203
7Complement and coagulation cascades_Homo sapiens_hsa046102.30702836
8Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.00704574
9Osteoclast differentiation_Homo sapiens_hsa043801.93049371
10Antigen processing and presentation_Homo sapiens_hsa046121.91637877
11Prion diseases_Homo sapiens_hsa050201.87131409
12Pertussis_Homo sapiens_hsa051331.85670697
13Leishmaniasis_Homo sapiens_hsa051401.78311834
14Vibrio cholerae infection_Homo sapiens_hsa051101.68434521
15Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.64733097
16Tuberculosis_Homo sapiens_hsa051521.58324988
17SNARE interactions in vesicular transport_Homo sapiens_hsa041301.51042553
18Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.47916094
19Sulfur metabolism_Homo sapiens_hsa009201.47574377
20Folate biosynthesis_Homo sapiens_hsa007901.45773268
21Phagosome_Homo sapiens_hsa041451.43435909
22Caffeine metabolism_Homo sapiens_hsa002321.41573911
23Asthma_Homo sapiens_hsa053101.37562492
24Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.37395544
25B cell receptor signaling pathway_Homo sapiens_hsa046621.36779401
26Mineral absorption_Homo sapiens_hsa049781.36141014
27Legionellosis_Homo sapiens_hsa051341.34563828
28Intestinal immune network for IgA production_Homo sapiens_hsa046721.32361733
29Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.26968107
30Pentose phosphate pathway_Homo sapiens_hsa000301.26842809
31Regulation of autophagy_Homo sapiens_hsa041401.22478909
32Toll-like receptor signaling pathway_Homo sapiens_hsa046201.20949550
33Nitrogen metabolism_Homo sapiens_hsa009101.18648008
34Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.11052139
35Synaptic vesicle cycle_Homo sapiens_hsa047211.06637438
36Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.05018366
37Pentose and glucuronate interconversions_Homo sapiens_hsa000401.03899803
38Drug metabolism - other enzymes_Homo sapiens_hsa009831.03370848
39Apoptosis_Homo sapiens_hsa042100.98003553
40Malaria_Homo sapiens_hsa051440.97533526
41Endocytosis_Homo sapiens_hsa041440.96225287
42* Glycerophospholipid metabolism_Homo sapiens_hsa005640.94486958
43Glutathione metabolism_Homo sapiens_hsa004800.93457132
44Vitamin digestion and absorption_Homo sapiens_hsa049770.92003818
45Shigellosis_Homo sapiens_hsa051310.90652679
46Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.89319263
47Toxoplasmosis_Homo sapiens_hsa051450.89006384
48Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.86654259
49Rheumatoid arthritis_Homo sapiens_hsa053230.86014870
50Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.85019857
51Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.83821178
52Maturity onset diabetes of the young_Homo sapiens_hsa049500.82309173
53Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.80491013
54Chronic myeloid leukemia_Homo sapiens_hsa052200.79954639
55Renin-angiotensin system_Homo sapiens_hsa046140.78986435
56Allograft rejection_Homo sapiens_hsa053300.73213718
57Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.71828878
58Leukocyte transendothelial migration_Homo sapiens_hsa046700.71813867
59Bladder cancer_Homo sapiens_hsa052190.69805279
60Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.68702561
61Primary bile acid biosynthesis_Homo sapiens_hsa001200.68676662
62Oxidative phosphorylation_Homo sapiens_hsa001900.67219104
63Galactose metabolism_Homo sapiens_hsa000520.67004322
64Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.66326060
65Measles_Homo sapiens_hsa051620.65873247
66Influenza A_Homo sapiens_hsa051640.65147620
67Sulfur relay system_Homo sapiens_hsa041220.62667387
68PPAR signaling pathway_Homo sapiens_hsa033200.62631651
69Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.62514070
70Pancreatic cancer_Homo sapiens_hsa052120.62122263
71Fructose and mannose metabolism_Homo sapiens_hsa000510.62006679
72Butanoate metabolism_Homo sapiens_hsa006500.61059414
73Epstein-Barr virus infection_Homo sapiens_hsa051690.60956367
74Salmonella infection_Homo sapiens_hsa051320.60423648
75Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.60371787
76p53 signaling pathway_Homo sapiens_hsa041150.59071789
77mTOR signaling pathway_Homo sapiens_hsa041500.58966111
78Tryptophan metabolism_Homo sapiens_hsa003800.57213615
79AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.55799618
80Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.55771327
81Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.55467673
82Autoimmune thyroid disease_Homo sapiens_hsa053200.55457365
83Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.54622524
84Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.53983487
85Type I diabetes mellitus_Homo sapiens_hsa049400.53432802
86NF-kappa B signaling pathway_Homo sapiens_hsa040640.52931152
87Renal cell carcinoma_Homo sapiens_hsa052110.52449486
88Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.51893723
89Phototransduction_Homo sapiens_hsa047440.51514754
90Hepatitis B_Homo sapiens_hsa051610.51345133
91Amoebiasis_Homo sapiens_hsa051460.50988139
92Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.50738884
93Hematopoietic cell lineage_Homo sapiens_hsa046400.50349484
94Chemical carcinogenesis_Homo sapiens_hsa052040.50179514
95Platelet activation_Homo sapiens_hsa046110.50007358
96Chemokine signaling pathway_Homo sapiens_hsa040620.49454652
97Arachidonic acid metabolism_Homo sapiens_hsa005900.49446907
98Dilated cardiomyopathy_Homo sapiens_hsa054140.49115733
99Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.48221669
100Graft-versus-host disease_Homo sapiens_hsa053320.46975057
101Ether lipid metabolism_Homo sapiens_hsa005650.46385647
102Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.46217878
103Acute myeloid leukemia_Homo sapiens_hsa052210.45695979
104Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.45089413
105Adipocytokine signaling pathway_Homo sapiens_hsa049200.43953278
106Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.43620503
107Sphingolipid metabolism_Homo sapiens_hsa006000.42970350
108ABC transporters_Homo sapiens_hsa020100.42550084
109Glycerolipid metabolism_Homo sapiens_hsa005610.41622713
110N-Glycan biosynthesis_Homo sapiens_hsa005100.41440837
111Biosynthesis of amino acids_Homo sapiens_hsa012300.40639420
112Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.40591247
113Selenocompound metabolism_Homo sapiens_hsa004500.40535007
114Jak-STAT signaling pathway_Homo sapiens_hsa046300.40250636
115Proteasome_Homo sapiens_hsa030500.40175501
116Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.39878225
117Fatty acid elongation_Homo sapiens_hsa000620.39303084
118Sphingolipid signaling pathway_Homo sapiens_hsa040710.39052936
119Insulin resistance_Homo sapiens_hsa049310.38608778
120Neurotrophin signaling pathway_Homo sapiens_hsa047220.38569808
121HIF-1 signaling pathway_Homo sapiens_hsa040660.38309189
122Collecting duct acid secretion_Homo sapiens_hsa049660.37971146
123Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.37506380
124Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.37049542
125RNA transport_Homo sapiens_hsa030130.36753509
126Cell cycle_Homo sapiens_hsa041100.36186304
127Colorectal cancer_Homo sapiens_hsa052100.35552152
128Herpes simplex infection_Homo sapiens_hsa051680.35297635
1292-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.34824479
130Arginine biosynthesis_Homo sapiens_hsa002200.34029930
131Longevity regulating pathway - mammal_Homo sapiens_hsa042110.33416714
132FoxO signaling pathway_Homo sapiens_hsa040680.32887836
133Steroid biosynthesis_Homo sapiens_hsa001000.31486950
134NOD-like receptor signaling pathway_Homo sapiens_hsa046210.31032025
135Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.28996404
136Ovarian steroidogenesis_Homo sapiens_hsa049130.28707096
137Viral myocarditis_Homo sapiens_hsa054160.27797342
138beta-Alanine metabolism_Homo sapiens_hsa004100.27517602
139Proteoglycans in cancer_Homo sapiens_hsa052050.26884490
140Peroxisome_Homo sapiens_hsa041460.26391214
141TNF signaling pathway_Homo sapiens_hsa046680.26260968
142Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.25686559
143Metabolic pathways_Homo sapiens_hsa011000.25043532
144ECM-receptor interaction_Homo sapiens_hsa045120.22532877
145Steroid hormone biosynthesis_Homo sapiens_hsa001400.20756311
146Oxytocin signaling pathway_Homo sapiens_hsa049210.20729521
147Focal adhesion_Homo sapiens_hsa045100.20335800
148Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.18645549
149Starch and sucrose metabolism_Homo sapiens_hsa005000.16119599
150Vascular smooth muscle contraction_Homo sapiens_hsa042700.15721613
151Renin secretion_Homo sapiens_hsa049240.14413397

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