PLA2G16

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of translational fidelity (GO:0006450)9.50738251
2modulation by symbiont of host cellular process (GO:0044068)9.46671603
3negative regulation of viral entry into host cell (GO:0046597)7.70420767
4neutrophil activation involved in immune response (GO:0002283)7.44378368
5negative regulation of viral release from host cell (GO:1902187)6.56169131
6fatty acid elongation (GO:0030497)6.46853219
7calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)6.22090425
8creatine metabolic process (GO:0006600)5.98504760
9modulation by virus of host morphology or physiology (GO:0019048)5.84190639
10vesicle targeting (GO:0006903)5.72037895
11regulation of viral entry into host cell (GO:0046596)5.62492000
12regulation of translational elongation (GO:0006448)5.53819905
13negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)5.47661656
14axon ensheathment (GO:0008366)5.40082387
15ensheathment of neurons (GO:0007272)5.40082387
16myelination (GO:0042552)5.33517467
17myelin maintenance (GO:0043217)5.32100770
18beta-amyloid metabolic process (GO:0050435)5.28823703
19transcytosis (GO:0045056)5.05003894
20long-chain fatty-acyl-CoA metabolic process (GO:0035336)5.01224996
21long-chain fatty acid biosynthetic process (GO:0042759)5.00995596
22long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)4.97824415
23skin morphogenesis (GO:0043589)4.88802587
24regulation of sequestering of triglyceride (GO:0010889)4.85749578
25fatty-acyl-CoA metabolic process (GO:0035337)4.82630071
26positive regulation of receptor recycling (GO:0001921)4.67889549
27fatty-acyl-CoA biosynthetic process (GO:0046949)4.67581521
28negative regulation of protein localization to cell surface (GO:2000009)4.49950854
29regulation of lipoprotein metabolic process (GO:0050746)4.49688664
30positive regulation of oligodendrocyte differentiation (GO:0048714)4.45078231
31regulation of viral release from host cell (GO:1902186)4.43451260
32thioester biosynthetic process (GO:0035384)4.41068404
33acyl-CoA biosynthetic process (GO:0071616)4.41068404
34cellular response to zinc ion (GO:0071294)4.36936272
35response to lipoprotein particle (GO:0055094)4.30320612
36import into cell (GO:0098657)4.15843074
37triglyceride biosynthetic process (GO:0019432)4.08880944
38triglyceride catabolic process (GO:0019433)4.06853606
39response to dietary excess (GO:0002021)4.06012971
40basic amino acid transport (GO:0015802)3.98855839
41response to methylmercury (GO:0051597)3.94942448
42low-density lipoprotein particle clearance (GO:0034383)3.93355369
43neutral lipid biosynthetic process (GO:0046460)3.89765131
44acylglycerol biosynthetic process (GO:0046463)3.89765131
45macrophage activation involved in immune response (GO:0002281)3.88197581
46cholesterol biosynthetic process (GO:0006695)3.81668676
47mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.79532927
48endoplasmic reticulum calcium ion homeostasis (GO:0032469)3.75602483
49tight junction assembly (GO:0070830)3.68072315
50regulation of meiosis I (GO:0060631)3.65724873
51negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)3.63932499
52mitochondrion degradation (GO:0000422)3.62205319
53antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.59244721
54amyloid precursor protein metabolic process (GO:0042982)3.54205969
55oligodendrocyte differentiation (GO:0048709)3.53023157
56positive regulation of mitochondrial calcium ion concentration (GO:0051561)3.51671759
57negative regulation of receptor activity (GO:2000272)3.51128027
58glycerolipid catabolic process (GO:0046503)3.48128132
59membrane raft organization (GO:0031579)3.46152551
60neutral lipid catabolic process (GO:0046461)3.45706751
61acylglycerol catabolic process (GO:0046464)3.45706751
62sterol biosynthetic process (GO:0016126)3.44680862
63membrane tubulation (GO:0097320)3.44422832
64cellular response to epinephrine stimulus (GO:0071872)3.44067234
65very long-chain fatty acid metabolic process (GO:0000038)3.43161362
66autophagic vacuole fusion (GO:0000046)3.42652214
67lipid particle organization (GO:0034389)3.40406221
68positive regulation of glomerulus development (GO:0090193)3.38204331
69cerebral cortex neuron differentiation (GO:0021895)3.37425938
70modification by symbiont of host morphology or physiology (GO:0044003)3.37037657
71brain morphogenesis (GO:0048854)3.35452133
72biotin metabolic process (GO:0006768)3.35068308
73establishment of mitochondrion localization (GO:0051654)3.34048467
74photoreceptor cell differentiation (GO:0046530)3.28697848
75eye photoreceptor cell differentiation (GO:0001754)3.28697848
76brown fat cell differentiation (GO:0050873)3.28668519
77amino acid salvage (GO:0043102)3.27230703
78L-methionine salvage (GO:0071267)3.27230703
79L-methionine biosynthetic process (GO:0071265)3.27230703
80cellular response to pH (GO:0071467)3.26771339
81white fat cell differentiation (GO:0050872)3.24780556
82response to epinephrine (GO:0071871)3.24029808
83L-glutamate transport (GO:0015813)3.12025303
84branched-chain amino acid catabolic process (GO:0009083)3.09206693
85regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:23.09151259
86respiratory electron transport chain (GO:0022904)3.08422951
87acidic amino acid transport (GO:0015800)3.08043512
88regulation of collateral sprouting (GO:0048670)3.06396473
89astrocyte development (GO:0014002)3.06206444
90acyl-CoA metabolic process (GO:0006637)3.04936967
91thioester metabolic process (GO:0035383)3.04936967
92negative regulation of acute inflammatory response (GO:0002674)3.04005395
93negative regulation of protein tyrosine kinase activity (GO:0061099)3.03679563
94GPI anchor biosynthetic process (GO:0006506)3.02962534
95fatty acid beta-oxidation (GO:0006635)3.01904313
96negative regulation of neurotransmitter transport (GO:0051589)3.01798041
97electron transport chain (GO:0022900)3.00084068
98S-adenosylmethionine metabolic process (GO:0046500)2.99870867
99membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.94870251
100isoprenoid biosynthetic process (GO:0008299)2.94526366
101ethanol oxidation (GO:0006069)2.94322757
102cellular ketone body metabolic process (GO:0046950)2.93928238
103phosphatidic acid biosynthetic process (GO:0006654)2.93163205
104phosphatidic acid metabolic process (GO:0046473)2.93163205
105dorsal/ventral neural tube patterning (GO:0021904)2.91115328
106negative regulation of neurotransmitter secretion (GO:0046929)2.89176100
107response to acidic pH (GO:0010447)2.88504515
108virion attachment to host cell (GO:0019062)2.88376841
109adhesion of symbiont to host cell (GO:0044650)2.88376841
110response to redox state (GO:0051775)2.87805814
111negative regulation of execution phase of apoptosis (GO:1900118)2.86087817
112glycerophospholipid catabolic process (GO:0046475)2.85768365
113peptidyl-tyrosine autophosphorylation (GO:0038083)2.84644151
114neutrophil activation (GO:0042119)2.83770625
115fatty acid catabolic process (GO:0009062)2.82911508
116regulation of receptor recycling (GO:0001919)2.82329844
117cerebellar Purkinje cell layer development (GO:0021680)2.82158218
118positive regulation of glial cell differentiation (GO:0045687)2.81793831
119GPI anchor metabolic process (GO:0006505)2.80619115
120amino-acid betaine metabolic process (GO:0006577)2.80525116
121branched-chain amino acid metabolic process (GO:0009081)2.79566962
122L-amino acid import (GO:0043092)2.76411988
123multicellular organism reproduction (GO:0032504)2.75882676
124regulation of somitogenesis (GO:0014807)2.75855521
125negative regulation of JUN kinase activity (GO:0043508)2.75154648
126tissue regeneration (GO:0042246)2.72158558
127substantia nigra development (GO:0021762)2.72155630
128regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.70863759
129valine metabolic process (GO:0006573)2.68434375
130amyloid precursor protein catabolic process (GO:0042987)2.68230380
131triglyceride metabolic process (GO:0006641)2.68147755
132regulation of lipopolysaccharide-mediated signaling pathway (GO:0031664)2.68053777
133synaptic vesicle docking involved in exocytosis (GO:0016081)2.67128649
134mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.64636945
135CDP-diacylglycerol biosynthetic process (GO:0016024)2.64581203
136regulation of metalloenzyme activity (GO:0048552)2.64291535
137positive regulation of meiosis (GO:0045836)2.63757251
138positive regulation of gliogenesis (GO:0014015)2.62909215
139acetyl-CoA metabolic process (GO:0006084)2.61739750
140ATP synthesis coupled proton transport (GO:0015986)2.61560248
141energy coupled proton transport, down electrochemical gradient (GO:0015985)2.61560248
142ketone body metabolic process (GO:1902224)2.61007461
143piRNA metabolic process (GO:0034587)2.60894992
144myelination in peripheral nervous system (GO:0022011)2.60640790
145peripheral nervous system axon ensheathment (GO:0032292)2.60640790
146regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.60114237
147asymmetric protein localization (GO:0008105)2.58881161
148axon development (GO:0061564)2.58731377
149fatty acid transmembrane transport (GO:1902001)2.58527354
150negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)2.58244705
151response to pH (GO:0009268)2.57250232
152carnitine shuttle (GO:0006853)2.56828365
153organelle membrane fusion (GO:0090174)2.56595866
154fatty acid homeostasis (GO:0055089)2.55347125
155fatty acid oxidation (GO:0019395)2.54264445
156positive regulation of meiotic cell cycle (GO:0051446)2.52804457
157fatty acid biosynthetic process (GO:0006633)2.51895165
158lipid oxidation (GO:0034440)2.51695051
159positive regulation of pseudopodium assembly (GO:0031274)2.51485160
160positive regulation of insulin receptor signaling pathway (GO:0046628)2.51406949
161CDP-diacylglycerol metabolic process (GO:0046341)2.48191218
162natural killer cell mediated cytotoxicity (GO:0042267)2.46373124
163natural killer cell mediated immunity (GO:0002228)2.46373124
164positive regulation of receptor activity (GO:2000273)2.45501939
165granulocyte activation (GO:0036230)2.43618477
166seminiferous tubule development (GO:0072520)2.42653897
167acylglycerol homeostasis (GO:0055090)2.37561692
168triglyceride homeostasis (GO:0070328)2.37561692
169negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)2.37548747
170ribosomal small subunit assembly (GO:0000028)2.37143825
171positive regulation of tolerance induction (GO:0002645)2.36129945
172regulation of phospholipase A2 activity (GO:0032429)2.35955098
173positive regulation of translation (GO:0045727)2.35393128
174mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.33955089
175synaptic vesicle maturation (GO:0016188)2.31814609
176ethanol metabolic process (GO:0006067)2.31066986
177regulation of glomerulus development (GO:0090192)2.31054852
178ribosomal small subunit biogenesis (GO:0042274)2.29128038
179poly(A)+ mRNA export from nucleus (GO:0016973)12.2571919
180modulation by virus of host process (GO:0019054)11.5341850
181axon ensheathment in central nervous system (GO:0032291)10.2065043
182central nervous system myelination (GO:0022010)10.2065043

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse7.00951408
2TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.14917463
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.80904312
4STAT6_21828071_ChIP-Seq_BEAS2B_Human2.57173376
5ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.24716389
6SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.21463144
7PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.19951689
8SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.12008498
9CDX2_19796622_ChIP-Seq_MESCs_Mouse2.05940310
10MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.04417317
11EZH2_22144423_ChIP-Seq_EOC_Human1.94581410
12CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.93422526
13GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.77488742
14EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.76933556
15TRIM28_21343339_ChIP-Seq_HEK293_Human1.73663276
16CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.73197201
17TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.72674439
18PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.70131110
19PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.69260116
20E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.59326117
21FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.59013477
22RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.57438565
23SMAD3_21741376_ChIP-Seq_HESCs_Human1.57114027
24EP300_21415370_ChIP-Seq_HL-1_Mouse1.56561853
25CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.52863469
26ER_23166858_ChIP-Seq_MCF-7_Human1.50594821
27EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.50554727
28RARG_19884340_ChIP-ChIP_MEFs_Mouse1.47304734
29ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.46762354
30OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.46240303
31NRF2_20460467_ChIP-Seq_MEFs_Mouse1.45739326
32NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.45739326
33SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.41864024
34SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.40772426
35ESR1_20079471_ChIP-ChIP_T-47D_Human1.40550280
36IGF1R_20145208_ChIP-Seq_DFB_Human1.37747813
37MTF2_20144788_ChIP-Seq_MESCs_Mouse1.36474331
38CLOCK_20551151_ChIP-Seq_293T_Human1.36411428
39SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.35683507
40RAD21_21589869_ChIP-Seq_MESCs_Mouse1.34086589
41TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.33143914
42VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.33058733
43TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.29756436
44GATA2_21666600_ChIP-Seq_HMVEC_Human1.26188544
45* ERA_21632823_ChIP-Seq_H3396_Human1.26032742
46STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.25201212
47EGR1_23403033_ChIP-Seq_LIVER_Mouse1.23181282
48RNF2_18974828_ChIP-Seq_MESCs_Mouse1.22367021
49EZH2_18974828_ChIP-Seq_MESCs_Mouse1.22367021
50EOMES_21245162_ChIP-Seq_HESCs_Human1.22076114
51TBX20_22328084_ChIP-Seq_HEART_Mouse1.20545388
52TBX20_22080862_ChIP-Seq_HEART_Mouse1.20545388
53* CDX2_22108803_ChIP-Seq_LS180_Human1.19992285
54PPARA_22158963_ChIP-Seq_LIVER_Mouse1.18686923
55IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.17114231
56* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.16499887
57GATA1_19941826_ChIP-Seq_K562_Human1.15132466
58ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.14860113
59RXR_22158963_ChIP-Seq_LIVER_Mouse1.14502828
60GBX2_23144817_ChIP-Seq_PC3_Human1.14202965
61* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.14161915
62FOXO3_23340844_ChIP-Seq_DLD1_Human1.13174068
63AR_21572438_ChIP-Seq_LNCaP_Human1.13002286
64P53_21459846_ChIP-Seq_SAOS-2_Human1.12583985
65* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse1.11920584
66ERG_21242973_ChIP-ChIP_JURKAT_Human1.11526443
67SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.11080260
68BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.10882661
69LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.10434532
70KLF4_19829295_ChIP-Seq_ESCs_Human1.08897634
71* MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.08660330
72PPAR_26484153_Chip-Seq_NCI-H1993_Human1.08158849
73PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.08087637
74SA1_27219007_Chip-Seq_Bcells_Human1.07532756
75TET1_21451524_ChIP-Seq_MESCs_Mouse1.07406366
76* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.06300100
77SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.06158431
78WT1_19549856_ChIP-ChIP_CCG9911_Human1.05787761
79ESR1_21235772_ChIP-Seq_MCF-7_Human1.05478422
80SOX2_21211035_ChIP-Seq_LN229_Human1.04680345
81GATA3_21878914_ChIP-Seq_MCF-7_Human1.03969242
82ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.03949328
83* ESR2_21235772_ChIP-Seq_MCF-7_Human1.03592103
84NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.03537500
85BCAT_22108803_ChIP-Seq_LS180_Human1.03177249
86CTCF_27219007_Chip-Seq_Bcells_Human1.02434099
87REST_21632747_ChIP-Seq_MESCs_Mouse1.02236698
88JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.01542908
89MYC_19829295_ChIP-Seq_ESCs_Human1.01455530
90ETS1_21867929_ChIP-Seq_TH2_Mouse1.00696924
91CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.00150598
92FOXH1_21741376_ChIP-Seq_EPCs_Human0.99363015
93UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.99077545
94JARID2_20064375_ChIP-Seq_MESCs_Mouse0.98764765
95EZH2_27294783_Chip-Seq_ESCs_Mouse0.98706834
96SMAD4_21741376_ChIP-Seq_HESCs_Human0.98482510
97SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.97693956
98* CBP_21632823_ChIP-Seq_H3396_Human0.97146939
99EED_16625203_ChIP-ChIP_MESCs_Mouse0.96721730
100SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.96539562
101TCF4_22108803_ChIP-Seq_LS180_Human0.95977517
102NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.94949945
103EZH2_27304074_Chip-Seq_ESCs_Mouse0.93826626
104ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.93444269
105LXR_22292898_ChIP-Seq_THP-1_Human0.92628747
106* HOXB7_26014856_ChIP-Seq_BT474_Human0.92472931
107CTBP1_25329375_ChIP-Seq_LNCAP_Human0.92463296
108FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.91974070
109SMAD3_21741376_ChIP-Seq_ESCs_Human0.91704642
110P68_20966046_ChIP-Seq_HELA_Human0.91570978
111SOX2_20726797_ChIP-Seq_SW620_Human0.91277009
112SUZ12_27294783_Chip-Seq_ESCs_Mouse0.90981608
113SOX2_27498859_Chip-Seq_STOMACH_Mouse0.90758641
114FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.90693042
115ZFP57_27257070_Chip-Seq_ESCs_Mouse0.90514052
116TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.90105218
117EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.90095392
118LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.89735745
119* CSB_26484114_Chip-Seq_FIBROBLAST_Human0.89675621
120* AR_25329375_ChIP-Seq_VCAP_Human0.88296091
121SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.88204898
122TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88184896
123RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.87146676
124SOX2_19829295_ChIP-Seq_ESCs_Human0.86829556
125NANOG_19829295_ChIP-Seq_ESCs_Human0.86829556
126CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.86785975
127CJUN_26792858_Chip-Seq_BT549_Human0.86600567
128EGR1_19032775_ChIP-ChIP_M12_Human0.86537705
129TAF2_19829295_ChIP-Seq_ESCs_Human0.86533441
130MYC_19915707_ChIP-ChIP_AK7_Human0.86400282
131BMI1_23680149_ChIP-Seq_NPCS_Mouse0.86049370
132SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.85861088
133FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.84835846
134RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.83203551
135NANOG_20526341_ChIP-Seq_ESCs_Human0.83149843
136VDR_24787735_ChIP-Seq_THP-1_Human0.82861148
137FOXA1_25552417_ChIP-Seq_VCAP_Human0.82526193
138PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.82491235
139TAL1_26923725_Chip-Seq_HPCs_Mouse0.82202269
140HTT_18923047_ChIP-ChIP_STHdh_Human0.82116405
141* PIAS1_25552417_ChIP-Seq_VCAP_Human0.81605747
142LXR_22158963_ChIP-Seq_LIVER_Mouse0.81038434
143POU3F2_20337985_ChIP-ChIP_501MEL_Human0.80579807
144JARID2_20075857_ChIP-Seq_MESCs_Mouse0.79516488
145EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.79408133
146PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.77628683
147VDR_22108803_ChIP-Seq_LS180_Human0.76518955
148CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.75162898
149GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.74810829
150STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.74677145
151OCT4_20526341_ChIP-Seq_ESCs_Human0.74156147
152AUTS2_25519132_ChIP-Seq_293T-REX_Human0.74095571
153STAT1_20625510_ChIP-Seq_HELA_Human0.73715933
154PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.73260719
155FOXH1_21741376_ChIP-Seq_ESCs_Human0.72945995
156GATA2_19941826_ChIP-Seq_K562_Human0.72936700
157* AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.72767774
158RNF2_27304074_Chip-Seq_ESCs_Mouse0.71426154
159DROSHA_22980978_ChIP-Seq_HELA_Human0.71413242
160SMAD3_21741376_ChIP-Seq_EPCs_Human0.70984365
161TAF15_26573619_Chip-Seq_HEK293_Human0.70441466

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006054_spinal_hemorrhage5.78917463
2MP0005670_abnormal_white_adipose4.30626046
3MP0000920_abnormal_myelination4.29651388
4MP0003950_abnormal_plasma_membrane3.93944021
5MP0004185_abnormal_adipocyte_glucose3.76289776
6MP0005666_abnormal_adipose_tissue3.56503185
7MP0002138_abnormal_hepatobiliary_system3.47505979
8MP0004130_abnormal_muscle_cell3.28552396
9MP0003690_abnormal_glial_cell2.87987035
10MP0005375_adipose_tissue_phenotype2.83724694
11MP0008438_abnormal_cutaneous_collagen2.65251911
12MP0002837_dystrophic_cardiac_calcinosis2.62384454
13MP0000749_muscle_degeneration2.38896920
14MP0002089_abnormal_postnatal_growth/wei2.21750620
15MP0002254_reproductive_system_inflammat2.17344985
16MP0004147_increased_porphyrin_level2.16036888
17MP0000013_abnormal_adipose_tissue2.16011862
18MP0000003_abnormal_adipose_tissue2.11800739
19MP0002653_abnormal_ependyma_morphology2.05847053
20MP0004858_abnormal_nervous_system2.02164630
21MP0004036_abnormal_muscle_relaxation1.99139462
22MP0003329_amyloid_beta_deposits1.96566207
23MP0003136_yellow_coat_color1.95540851
24MP0005360_urolithiasis1.94297899
25MP0000751_myopathy1.91852754
26MP0002971_abnormal_brown_adipose1.87367347
27MP0001915_intracranial_hemorrhage1.85925879
28MP0001661_extended_life_span1.83939347
29MP0001529_abnormal_vocalization1.82773844
30MP0004043_abnormal_pH_regulation1.77254004
31MP0010329_abnormal_lipoprotein_level1.76577717
32MP0010386_abnormal_urinary_bladder1.74819019
33MP0005171_absent_coat_pigmentation1.73583653
34MP0000747_muscle_weakness1.72127481
35MP0004145_abnormal_muscle_electrophysio1.71611236
36MP0005451_abnormal_body_composition1.69747437
37MP0003195_calcinosis1.69458222
38MP0003879_abnormal_hair_cell1.65022181
39MP0005595_abnormal_vascular_smooth1.63245861
40MP0005646_abnormal_pituitary_gland1.60106208
41MP0003646_muscle_fatigue1.57184507
42MP0005330_cardiomyopathy1.56331361
43MP0003186_abnormal_redox_activity1.55720790
44MP0009780_abnormal_chondrocyte_physiolo1.53896360
45MP0003634_abnormal_glial_cell1.53548405
46MP0003806_abnormal_nucleotide_metabolis1.47866691
47MP0001984_abnormal_olfaction1.47346378
48MP0003724_increased_susceptibility_to1.43510518
49MP0005620_abnormal_muscle_contractility1.36180143
50MP0003635_abnormal_synaptic_transmissio1.34513836
51MP0002118_abnormal_lipid_homeostasis1.34098376
52MP0004142_abnormal_muscle_tone1.32962860
53MP0004087_abnormal_muscle_fiber1.28797922
54MP0004381_abnormal_hair_follicle1.28150443
55MP0008775_abnormal_heart_ventricle1.25397700
56MP0001905_abnormal_dopamine_level1.24984495
57MP0004270_analgesia1.24506566
58MP0000759_abnormal_skeletal_muscle1.23083420
59MP0005423_abnormal_somatic_nervous1.22862051
60MP0004742_abnormal_vestibular_system1.22680378
61MP0005275_abnormal_skin_tensile1.22195799
62MP0006036_abnormal_mitochondrial_physio1.21056742
63MP0004885_abnormal_endolymph1.20975143
64MP0009745_abnormal_behavioral_response1.20927132
65MP0005058_abnormal_lysosome_morphology1.20648243
66MP0001299_abnormal_eye_distance/1.20183092
67MP0002272_abnormal_nervous_system1.19706691
68MP0004215_abnormal_myocardial_fiber1.18853692
69MP0000467_abnormal_esophagus_morphology1.18095473
70MP0002064_seizures1.17277631
71MP0005551_abnormal_eye_electrophysiolog1.17040078
72MP0002106_abnormal_muscle_physiology1.16980241
73MP0002972_abnormal_cardiac_muscle1.15481549
74MP0000613_abnormal_salivary_gland1.15040300
75MP0005334_abnormal_fat_pad1.14334632
76MP0002876_abnormal_thyroid_physiology1.13978484
77MP0001502_abnormal_circadian_rhythm1.11689842
78MP0004084_abnormal_cardiac_muscle1.08465976
79MP0002909_abnormal_adrenal_gland1.08342372
80MP0006138_congestive_heart_failure1.08213975
81MP0003656_abnormal_erythrocyte_physiolo1.07876960
82MP0008260_abnormal_autophagy1.07821418
83MP0000750_abnormal_muscle_regeneration1.07309060
84MP0005535_abnormal_body_temperature1.07151959
85MP0001486_abnormal_startle_reflex1.06256596
86MP0003137_abnormal_impulse_conducting1.06134251
87MP0005369_muscle_phenotype1.05628746
88MP0006276_abnormal_autonomic_nervous1.05178372
89MP0002638_abnormal_pupillary_reflex1.03791900
90MP0000604_amyloidosis1.03742964
91MP0002090_abnormal_vision1.03365386
92MP0001485_abnormal_pinna_reflex1.03293921
93MP0004859_abnormal_synaptic_plasticity1.03133636
94MP0010678_abnormal_skin_adnexa0.99829762
95MP0009115_abnormal_fat_cell0.99187636
96MP0003959_abnormal_lean_body0.97437366
97MP0004085_abnormal_heartbeat0.97007615
98MP0003633_abnormal_nervous_system0.96588264
99MP0002229_neurodegeneration0.95731915
100MP0003828_pulmonary_edema0.93716590
101MP0002796_impaired_skin_barrier0.93013205
102MP0003880_abnormal_central_pattern0.92324420
103MP0005410_abnormal_fertilization0.91415894
104MP0001944_abnormal_pancreas_morphology0.91290835
105MP0001348_abnormal_lacrimal_gland0.90536566
106MP0005409_darkened_coat_color0.90236160
107MP0003191_abnormal_cellular_cholesterol0.90045129
108MP0000647_abnormal_sebaceous_gland0.89923187
109MP0004134_abnormal_chest_morphology0.89243649
110MP0005584_abnormal_enzyme/coenzyme_acti0.88972607
111MP0002295_abnormal_pulmonary_circulatio0.88653204
112MP0001440_abnormal_grooming_behavior0.88161715
113MP0000343_altered_response_to0.87554540
114MP0008569_lethality_at_weaning0.87169603
115MP0002139_abnormal_hepatobiliary_system0.86503578
116MP0005645_abnormal_hypothalamus_physiol0.86346398
117MP0005448_abnormal_energy_balance0.86318768
118MP0002078_abnormal_glucose_homeostasis0.86227232
119MP0003631_nervous_system_phenotype0.85919495
120MP0005452_abnormal_adipose_tissue0.85489278
121MP0004019_abnormal_vitamin_homeostasis0.84375546
122MP0005385_cardiovascular_system_phenoty0.83206091
123MP0001544_abnormal_cardiovascular_syste0.83206091
124MP0000383_abnormal_hair_follicle0.82925874
125MP0003283_abnormal_digestive_organ0.81668484
126MP0003221_abnormal_cardiomyocyte_apopto0.80898097
127MP0002693_abnormal_pancreas_physiology0.80267835
128MP0003868_abnormal_feces_composition0.79991164
129MP0005085_abnormal_gallbladder_physiolo0.79795826
130MP0001851_eye_inflammation0.79173570
131MP0002734_abnormal_mechanical_nocicepti0.78003695
132MP0004272_abnormal_basement_membrane0.77812383
133MP0002332_abnormal_exercise_endurance0.77213122
134MP0003632_abnormal_nervous_system0.76606988
135MP0001727_abnormal_embryo_implantation0.76318903
136MP0005332_abnormal_amino_acid0.76082362
137MP0002108_abnormal_muscle_morphology0.75906146
138MP0002063_abnormal_learning/memory/cond0.75816521
139MP0005379_endocrine/exocrine_gland_phen0.74383342
140MP0005388_respiratory_system_phenotype0.72437194
141MP0002133_abnormal_respiratory_system0.72437194
142MP0002822_catalepsy0.72412010
143MP0001756_abnormal_urination0.71880479
144MP0004484_altered_response_of0.71348694
145MP0006082_CNS_inflammation0.70482636
146MP0003011_delayed_dark_adaptation0.69658540
147MP0000230_abnormal_systemic_arterial0.68627855
148MP0001501_abnormal_sleep_pattern0.67656492
149MP0009643_abnormal_urine_homeostasis0.66971034

Predicted human phenotypes

RankGene SetZ-score
1Disinhibition (HP:0000734)8.70618009
2Progressive external ophthalmoplegia (HP:0000590)6.76112389
3Upper motor neuron abnormality (HP:0002127)6.37240772
4Inappropriate behavior (HP:0000719)5.78229369
5Personality changes (HP:0000751)5.48838392
6Mask-like facies (HP:0000298)5.37783406
7Degeneration of the lateral corticospinal tracts (HP:0002314)4.92570529
8Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)4.92570529
9Neurofibrillary tangles (HP:0002185)4.74129875
10Muscle fiber splitting (HP:0003555)4.61612127
11Polyphagia (HP:0002591)4.54124948
12Bone cyst (HP:0012062)4.20787766
13Difficulty running (HP:0009046)3.89788456
14Amyotrophic lateral sclerosis (HP:0007354)3.84626817
15Abnormality of the motor neurons (HP:0002450)3.82318265
16Abnormal neuron morphology (HP:0012757)3.82318265
17Hyporeflexia of lower limbs (HP:0002600)3.80425244
18Abnormal eating behavior (HP:0100738)3.76585242
19Onion bulb formation (HP:0003383)3.51227331
20Parakeratosis (HP:0001036)3.49486835
21Abnormality of glycolysis (HP:0004366)3.48236149
22Increased serum pyruvate (HP:0003542)3.48236149
23Muscle hypertrophy of the lower extremities (HP:0008968)3.46984884
24Acute necrotizing encephalopathy (HP:0006965)3.42826324
25Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.39643981
26Peripheral hypomyelination (HP:0007182)3.38127949
27Diminished motivation (HP:0000745)3.38113813
28Leukodystrophy (HP:0002415)3.30386595
29Exercise-induced myalgia (HP:0003738)3.28073530
30Segmental peripheral demyelination/remyelination (HP:0003481)3.22235148
31Spastic tetraparesis (HP:0001285)3.20441756
32Basal ganglia calcification (HP:0002135)3.20303550
33Acute encephalopathy (HP:0006846)3.18744026
34External ophthalmoplegia (HP:0000544)3.15362147
35Cerebral inclusion bodies (HP:0100314)3.13862999
36Abnormal mitochondria in muscle tissue (HP:0008316)3.12383297
37Syncope (HP:0001279)3.10830540
38Abnormality of the corticospinal tract (HP:0002492)3.09454005
39Calf muscle hypertrophy (HP:0008981)3.07831059
40Pathologic fracture (HP:0002756)3.04068241
41Sensory axonal neuropathy (HP:0003390)2.91250550
42Hypoglycemic coma (HP:0001325)2.90969192
43Methylmalonic acidemia (HP:0002912)2.88164260
44Hepatic necrosis (HP:0002605)2.86805821
45Progressive macrocephaly (HP:0004481)2.83292054
46Multiple enchondromatosis (HP:0005701)2.83055031
47Stridor (HP:0010307)2.80735361
48Acanthosis nigricans (HP:0000956)2.80275288
49Lower limb hyperreflexia (HP:0002395)2.79185071
50Trismus (HP:0000211)2.76347544
51Hepatocellular necrosis (HP:0001404)2.76107788
52Axonal loss (HP:0003447)2.75359533
53Oligomenorrhea (HP:0000876)2.75333966
54Apathy (HP:0000741)2.70703088
55Muscle fiber inclusion bodies (HP:0100299)2.70237387
56Gowers sign (HP:0003391)2.69405760
57Nemaline bodies (HP:0003798)2.67646609
58Mitochondrial inheritance (HP:0001427)2.67123341
59Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.66806903
60Myoglobinuria (HP:0002913)2.66124553
61Abnormal auditory evoked potentials (HP:0006958)2.62872730
62Hepatosplenomegaly (HP:0001433)2.62391681
63Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.62249369
64Increased muscle lipid content (HP:0009058)2.60028208
65Choanal stenosis (HP:0000452)2.57723800
66Hypoplasia of the uterus (HP:0000013)2.56694555
67Neck muscle weakness (HP:0000467)2.54054800
68Cortical dysplasia (HP:0002539)2.53977818
69Termporal pattern (HP:0011008)2.53900441
70Insidious onset (HP:0003587)2.53900441
71Myokymia (HP:0002411)2.53100747
72Congenital ichthyosiform erythroderma (HP:0007431)2.48894198
73Cerebral hypomyelination (HP:0006808)2.48086549
74Foot dorsiflexor weakness (HP:0009027)2.47097980
75Cerebral hemorrhage (HP:0001342)2.45705219
76Abnormality of serine family amino acid metabolism (HP:0010894)2.42557594
77Abnormality of glycine metabolism (HP:0010895)2.42557594
78Pheochromocytoma (HP:0002666)2.39978501
79Intention tremor (HP:0002080)2.32615022
80Generalized aminoaciduria (HP:0002909)2.31093694
81Muscle stiffness (HP:0003552)2.29348422
82Hypoplasia of the iris (HP:0007676)2.28600103
83Respiratory failure (HP:0002878)2.27894386
84Unilateral renal agenesis (HP:0000122)2.26466082
85Abnormality of the foot musculature (HP:0001436)2.26112235
86EMG: myopathic abnormalities (HP:0003458)2.24653481
87Dicarboxylic aciduria (HP:0003215)2.24049724
88Abnormality of dicarboxylic acid metabolism (HP:0010995)2.24049724
89Premature skin wrinkling (HP:0100678)2.23276284
90Renal Fanconi syndrome (HP:0001994)2.23023831
91Cerebral edema (HP:0002181)2.22321502
92Slow saccadic eye movements (HP:0000514)2.22019378
93Supranuclear gaze palsy (HP:0000605)2.20647218
94Increased CSF lactate (HP:0002490)2.18983381
95Exercise-induced muscle cramps (HP:0003710)2.18696874
96Abnormality of fatty-acid metabolism (HP:0004359)2.17930722
97Neuroendocrine neoplasm (HP:0100634)2.16327550
98Methylmalonic aciduria (HP:0012120)2.13539482
99Increased variability in muscle fiber diameter (HP:0003557)2.12224500
100Clumsiness (HP:0002312)2.11460603
101Gliosis (HP:0002171)2.10950583
102Rhabdomyolysis (HP:0003201)2.10063839
103Type 1 muscle fiber predominance (HP:0003803)2.08297491
104Spastic paraparesis (HP:0002313)2.07166606
105Retinal dysplasia (HP:0007973)2.05619451
106Lipoatrophy (HP:0100578)2.03500189
107Ileus (HP:0002595)2.03238394
108Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.02507251
1093-Methylglutaconic aciduria (HP:0003535)2.02057436
110Difficulty walking (HP:0002355)2.00644959
111Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)13.0867834
112Agnosia (HP:0010524)12.7725855
113Hypertriglyceridemia (HP:0002155)1.99135391
114Alacrima (HP:0000522)1.97505647
115Memory impairment (HP:0002354)1.97280650
116Abnormality of the calf musculature (HP:0001430)1.96716775
117Abnormality of aromatic amino acid family metabolism (HP:0004338)1.95851851
118Spastic gait (HP:0002064)1.95739546
119Dysmetria (HP:0001310)1.94432516
120Aplasia/hypoplasia of the uterus (HP:0008684)1.93008647
121Rapidly progressive (HP:0003678)1.90485690
122Nausea (HP:0002018)1.90210675
123Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.90204064
124Decreased activity of mitochondrial respiratory chain (HP:0008972)1.90204064
125Dilated cardiomyopathy (HP:0001644)1.89807457
126Infantile muscular hypotonia (HP:0008947)1.89610234
127Lipid accumulation in hepatocytes (HP:0006561)1.88941635
128Paraparesis (HP:0002385)1.88124606
129Paralysis (HP:0003470)1.86692664
130Hyperlipoproteinemia (HP:0010980)1.86245960
131Round ear (HP:0100830)1.85975675
132Atrophy/Degeneration involving motor neurons (HP:0007373)1.83616211
133Abnormality of skeletal muscle fiber size (HP:0012084)1.83103690
134Exercise intolerance (HP:0003546)1.82984870
135Hyperglycinuria (HP:0003108)1.82805751
136Metabolic alkalosis (HP:0200114)1.79984965
137Ankle clonus (HP:0011448)1.79822042
138Polar cataract (HP:0010696)1.79684494
139Large for gestational age (HP:0001520)1.78864150
140Scanning speech (HP:0002168)1.78768886
141Increased intramyocellular lipid droplets (HP:0012240)1.78255253
142Dementia (HP:0000726)1.77569833
143Aqueductal stenosis (HP:0002410)1.76368748
144Abnormality of the basal ganglia (HP:0002134)1.75464950
145Peripheral demyelination (HP:0011096)1.74591094
146Proximal tubulopathy (HP:0000114)1.73259810
147Dysphagia (HP:0002015)1.63193146
148Insulin-resistant diabetes mellitus (HP:0000831)1.62206151
149Hypophosphatemic rickets (HP:0004912)1.60409368
150Myoclonus (HP:0001336)1.59976849
151Abnormal cartilage morphology (HP:0002763)1.59873256
152Abnormality of the middle phalanges of the toes (HP:0010183)1.59281888
153Recurrent bacterial skin infections (HP:0005406)1.58959963
154Increased IgM level (HP:0003496)1.58344462
155Decreased circulating renin level (HP:0003351)1.57532640
156Congenital, generalized hypertrichosis (HP:0004540)1.57117640
157Oculomotor apraxia (HP:0000657)1.52309863
158Insulin resistance (HP:0000855)1.49423674
159Acute hepatic failure (HP:0006554)1.47884988
160Distal lower limb muscle weakness (HP:0009053)1.46565729
161Irritability (HP:0000737)1.38874253
162Short hallux (HP:0010109)1.38221601
163Turricephaly (HP:0000262)1.37936833
164Tetraplegia (HP:0002445)1.36354976
165Fetal akinesia sequence (HP:0001989)1.35123420
166Neuronal loss in central nervous system (HP:0002529)1.34435838
167Absent thumb (HP:0009777)1.34228497
168Renal cortical cysts (HP:0000803)1.34184450
169Abnormality of the proximal phalanges of the hand (HP:0009834)1.34140633
170Myotonia (HP:0002486)1.31207877
171Increased circulating renin level (HP:0000848)1.30385046
172Facial cleft (HP:0002006)1.28755430
173Aplasia/Hypoplasia of the hallux (HP:0008362)1.28204884
174Abnormality of renin-angiotensin system (HP:0000847)1.27956000
175Hemiplegia (HP:0002301)1.27788836
176Annular pancreas (HP:0001734)1.27627041
177Short chin (HP:0000331)1.26499806
178Urinary incontinence (HP:0000020)1.25698827
179Coronal craniosynostosis (HP:0004440)1.25155348
180Abnormality of glutamine family amino acid metabolism (HP:0010902)1.21360229
181Reduced subcutaneous adipose tissue (HP:0003758)1.21251226
182Bone pain (HP:0002653)1.18837192

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SCYL26.73914511
2EIF2AK16.43903475
3STK395.83411890
4EPHB13.67917583
5OXSR13.39184138
6EEF2K3.28180914
7MAPKAPK53.19742137
8MAPKAPK32.82131550
9PKN12.77944399
10WNK42.47456716
11PBK2.45534036
12BCKDK2.23081525
13PHKG22.21310925
14PHKG12.21310925
15OBSCN2.16963609
16MET2.08111573
17BCR1.96250781
18CAMK1D1.93603391
19FGFR21.84797505
20WNK11.80565390
21RPS6KB21.69936665
22MUSK1.66700407
23DYRK1A1.66218186
24LIMK11.59610915
25TESK11.59453014
26MAP2K61.56910890
27PTK2B1.56253869
28CAMK1G1.56145892
29CDK191.55684888
30FGFR11.51017401
31MST41.48075997
32MAP3K41.47784972
33MAP3K11.46437649
34LMTK21.39060982
35EPHA21.38443733
36TESK21.31990829
37PIK3CA1.31427818
38CAMK2D1.28059250
39ROCK21.22088899
40PRKD11.20465836
41NEK21.19669216
42TTN1.19166240
43TRPM71.18552296
44CSNK1G31.18405266
45CAMK2B1.18064717
46CSNK1A1L1.13018376
47NTRK31.11973172
48CLK11.08102989
49SGK4941.07262542
50SGK2231.07262542
51MARK11.05492938
52CSNK1G11.05008181
53MAPK151.04984210
54GRK51.03659223
55FRK1.00940295
56CAMK2G0.99611575
57BMPR1B0.98171133
58PINK10.96210967
59PDK20.92530039
60SIK10.91614280
61PDK30.91369082
62PDK40.91369082
63EPHA40.91165648
64PDPK10.90264845
65DYRK20.89331710
66PRKAA20.88614497
67DAPK20.87786226
68EPHA30.87038839
69NEK60.86895711
70RPS6KA50.85566454
71DMPK0.84610681
72TIE10.83703944
73PRKCQ0.82812653
74UHMK10.81695681
75MAP4K20.78502994
76MAP3K90.78404115
77CDK150.77138314
78GRK10.76000102
79GRK70.75479562
80LATS20.74801365
81NME20.73987800
82CDK180.72327885
83CDK11A0.72221043
84NEK90.72206832
85MAP2K20.71629985
86FGR0.71496687
87MARK20.71280638
88MAPK70.70579604
89NTRK10.68516613
90ILK0.68330666
91IRAK20.67896365
92PIK3CG0.67618270
93CSNK1G20.67567816
94MYLK0.66009212
95PRKCE0.65826762
96FER0.65798374
97DAPK30.64193308
98GSK3A0.62303060
99SYK0.61703838
100CDK140.58733340
101INSRR0.57266878
102PAK30.56492957
103ARAF0.56351951
104PRKCZ0.55881704
105MAPK130.55875954
106TNIK0.55860908
107CAMK2A0.54378339
108PRKD20.53791905
109MAPK120.53077257
110EPHB20.52693997
111PDK10.52266968
112PKN20.52190716
113PRKD30.51872644
114PRKCH0.51194248
115PRKG10.50323066
116IRAK10.50191021
117CSNK1D0.49145256
118NME10.47707151
119BLK0.46349579
120RIPK10.46098962
121MST1R0.46041418
122IGF1R0.45015650
123KSR20.44546511
124PRKACG0.43993664
125PRKCA0.42635930
126PRKACB0.40617303
127TLK10.39734930
128PRKAA10.38955770
129FLT30.38739780
130STK160.37847740
131CDK50.37775058
132PRKCG0.36674913
133TYRO30.36579778
134TEC0.36248185
135CAMK10.36172327
136PRKACA0.35619770
137ADRBK20.35488310
138NTRK20.35165781
139PRKG20.33961763
140FYN0.33264403
141ITK0.33210412
142ICK0.32687401
143MOS0.32568397
144PTK20.32565980
145DDR20.32258481
146JAK10.31583062
147HIPK20.30617158
148PAK60.30414739
149INSR0.30396867

Predicted pathways (KEGG)

RankGene SetZ-score
1Sulfur relay system_Homo sapiens_hsa041225.53638252
2Fatty acid elongation_Homo sapiens_hsa000624.81445594
3Terpenoid backbone biosynthesis_Homo sapiens_hsa009004.25808344
4Propanoate metabolism_Homo sapiens_hsa006403.39840940
5Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.90490016
6Steroid biosynthesis_Homo sapiens_hsa001002.89125392
7Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.82337784
8Oxidative phosphorylation_Homo sapiens_hsa001902.76076077
9Fatty acid biosynthesis_Homo sapiens_hsa000612.49657522
10mRNA surveillance pathway_Homo sapiens_hsa030152.48297434
11Vitamin B6 metabolism_Homo sapiens_hsa007502.44329427
12Fatty acid metabolism_Homo sapiens_hsa012122.42246858
13Parkinsons disease_Homo sapiens_hsa050122.39561047
14Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.34850207
15* Regulation of lipolysis in adipocytes_Homo sapiens_hsa049232.32102039
16PPAR signaling pathway_Homo sapiens_hsa033202.22626542
17Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.19375232
18Nitrogen metabolism_Homo sapiens_hsa009102.09724777
19Sulfur metabolism_Homo sapiens_hsa009202.06535239
20Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.01423742
21Alzheimers disease_Homo sapiens_hsa050102.00076337
22* Ether lipid metabolism_Homo sapiens_hsa005651.83702568
23Primary bile acid biosynthesis_Homo sapiens_hsa001201.77668138
24Fatty acid degradation_Homo sapiens_hsa000711.66568069
25Butanoate metabolism_Homo sapiens_hsa006501.61628157
26Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.54877511
27Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.53615228
28Circadian rhythm_Homo sapiens_hsa047101.53169854
29Protein export_Homo sapiens_hsa030601.53098902
30Synaptic vesicle cycle_Homo sapiens_hsa047211.51955254
31Histidine metabolism_Homo sapiens_hsa003401.48949034
32Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.43491049
33Glycerolipid metabolism_Homo sapiens_hsa005611.42596603
34Cardiac muscle contraction_Homo sapiens_hsa042601.42507726
35Pyruvate metabolism_Homo sapiens_hsa006201.40056591
36Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.39901261
37Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.37079310
38Peroxisome_Homo sapiens_hsa041461.34438299
39Sphingolipid metabolism_Homo sapiens_hsa006001.33528663
40Collecting duct acid secretion_Homo sapiens_hsa049661.30878914
41Huntingtons disease_Homo sapiens_hsa050161.26055163
42Nicotine addiction_Homo sapiens_hsa050331.17515529
43Dorso-ventral axis formation_Homo sapiens_hsa043201.16447475
44beta-Alanine metabolism_Homo sapiens_hsa004101.15524521
45Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.13975890
46Autoimmune thyroid disease_Homo sapiens_hsa053201.10378019
47Maturity onset diabetes of the young_Homo sapiens_hsa049501.05722720
48Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.05352417
49Phototransduction_Homo sapiens_hsa047441.04334092
50Insulin secretion_Homo sapiens_hsa049111.03645834
51Adipocytokine signaling pathway_Homo sapiens_hsa049200.98329289
52Bile secretion_Homo sapiens_hsa049760.97163767
53Arginine and proline metabolism_Homo sapiens_hsa003300.96947367
54Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.94722293
55Tryptophan metabolism_Homo sapiens_hsa003800.94098029
56Cysteine and methionine metabolism_Homo sapiens_hsa002700.93593492
57Amphetamine addiction_Homo sapiens_hsa050310.90187447
58RNA polymerase_Homo sapiens_hsa030200.86581078
59Glutathione metabolism_Homo sapiens_hsa004800.86442151
60Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.84466440
61Folate biosynthesis_Homo sapiens_hsa007900.83866483
62Carbon metabolism_Homo sapiens_hsa012000.80607694
63Arginine biosynthesis_Homo sapiens_hsa002200.79612626
64SNARE interactions in vesicular transport_Homo sapiens_hsa041300.78030641
65* Linoleic acid metabolism_Homo sapiens_hsa005910.76904502
662-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.76429361
67Fat digestion and absorption_Homo sapiens_hsa049750.74864256
68* alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.74841496
69Type I diabetes mellitus_Homo sapiens_hsa049400.73650537
70Cocaine addiction_Homo sapiens_hsa050300.73468601
71Morphine addiction_Homo sapiens_hsa050320.72242748
72* Glycerophospholipid metabolism_Homo sapiens_hsa005640.70798836
73Sphingolipid signaling pathway_Homo sapiens_hsa040710.69629149
74Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.68506497
75Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.67994756
76Pentose and glucuronate interconversions_Homo sapiens_hsa000400.67806932
77* Arachidonic acid metabolism_Homo sapiens_hsa005900.65694079
78Tight junction_Homo sapiens_hsa045300.65350456
79AMPK signaling pathway_Homo sapiens_hsa041520.64754079
80Tyrosine metabolism_Homo sapiens_hsa003500.62204986
81* Metabolic pathways_Homo sapiens_hsa011000.61516138
82Dilated cardiomyopathy_Homo sapiens_hsa054140.60221169
83Steroid hormone biosynthesis_Homo sapiens_hsa001400.58528188
84Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.58105728
85Renal cell carcinoma_Homo sapiens_hsa052110.57624520
86Circadian entrainment_Homo sapiens_hsa047130.57449459
87Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.55107251
88Long-term potentiation_Homo sapiens_hsa047200.53561103
89Aldosterone synthesis and secretion_Homo sapiens_hsa049250.53488104
90Starch and sucrose metabolism_Homo sapiens_hsa005000.53473645
91ECM-receptor interaction_Homo sapiens_hsa045120.51555189
92Lysosome_Homo sapiens_hsa041420.51349534
93Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.50497135
94Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.49354948
95Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.48221259
96Gap junction_Homo sapiens_hsa045400.45839597
97Malaria_Homo sapiens_hsa051440.45814330
98Vascular smooth muscle contraction_Homo sapiens_hsa042700.45598275
99Melanoma_Homo sapiens_hsa052180.45312715
100Caffeine metabolism_Homo sapiens_hsa002320.44735947
101Regulation of autophagy_Homo sapiens_hsa041400.44661521
102Rap1 signaling pathway_Homo sapiens_hsa040150.43339791
103Ribosome_Homo sapiens_hsa030100.40080436
104Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.39767078
105ABC transporters_Homo sapiens_hsa020100.39669570
106Taste transduction_Homo sapiens_hsa047420.39472153
107Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.37825950
108Renin secretion_Homo sapiens_hsa049240.36985689
109Pentose phosphate pathway_Homo sapiens_hsa000300.35143681
110Chemical carcinogenesis_Homo sapiens_hsa052040.32972487
111Axon guidance_Homo sapiens_hsa043600.32934557
112Allograft rejection_Homo sapiens_hsa053300.32914869
113Mineral absorption_Homo sapiens_hsa049780.32054607
114Ovarian steroidogenesis_Homo sapiens_hsa049130.30002631
115Pancreatic secretion_Homo sapiens_hsa049720.28975928
116Rheumatoid arthritis_Homo sapiens_hsa053230.28169720
117Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.27610357
118Endocytosis_Homo sapiens_hsa041440.27035921
119Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.26743677
120Serotonergic synapse_Homo sapiens_hsa047260.23379767
121Graft-versus-host disease_Homo sapiens_hsa053320.21648456
122Protein digestion and absorption_Homo sapiens_hsa049740.21505927
123Phenylalanine metabolism_Homo sapiens_hsa003600.20921178
124Retinol metabolism_Homo sapiens_hsa008300.19922697
125* Ras signaling pathway_Homo sapiens_hsa040140.19663742
126Phospholipase D signaling pathway_Homo sapiens_hsa040720.18878131
127Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.17957745
128Leukocyte transendothelial migration_Homo sapiens_hsa046700.17534244
129Gastric acid secretion_Homo sapiens_hsa049710.17384277
130Salivary secretion_Homo sapiens_hsa049700.16241299
131Viral myocarditis_Homo sapiens_hsa054160.14838878
132cAMP signaling pathway_Homo sapiens_hsa040240.13730579
133Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.12736146
134Asthma_Homo sapiens_hsa053100.11827697
135Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.11201122
136GABAergic synapse_Homo sapiens_hsa047270.11138190
137cGMP-PKG signaling pathway_Homo sapiens_hsa040220.11027370
138Vitamin digestion and absorption_Homo sapiens_hsa049770.10180342
139Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.09650214

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