PLA2G1B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a secreted member of the phospholipase A2 (PLA2) class of enzymes, which is produced by the pancreatic acinar cells. The encoded calcium-dependent enzyme catalyzes the hydrolysis of the sn-2 position of membrane glycerophospholipids to release arachidonic acid (AA) and lysophospholipids. AA is subsequently converted by downstream metabolic enzymes to several bioactive lipophilic compounds (eicosanoids), including prostaglandins (PGs) and leukotrienes (LTs). The enzyme may be involved in several physiological processes including cell contraction, cell proliferation and pathological response. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cobalamin metabolic process (GO:0009235)9.93527527
2peptidyl-proline hydroxylation (GO:0019511)8.43676441
3regulation of keratinocyte differentiation (GO:0045616)7.58414598
4intestinal absorption (GO:0050892)7.30816388
5regulation of keratinocyte proliferation (GO:0010837)7.29966132
6transcytosis (GO:0045056)7.25123179
7negative regulation of digestive system process (GO:0060457)7.05566410
8branched-chain amino acid catabolic process (GO:0009083)6.72495380
9protein hydroxylation (GO:0018126)6.53230308
10cholesterol catabolic process (GO:0006707)6.41162985
11sterol catabolic process (GO:0016127)6.41162985
12valine metabolic process (GO:0006573)6.26225115
13glycolipid catabolic process (GO:0019377)6.21630837
14proline biosynthetic process (GO:0006561)6.04847009
15regulation of proton transport (GO:0010155)5.82807417
16branched-chain amino acid metabolic process (GO:0009081)5.76984047
17cysteine metabolic process (GO:0006534)5.75416771
18membrane lipid catabolic process (GO:0046466)5.70521797
19cellular protein catabolic process (GO:0044257)5.60633611
20regulation of acrosome reaction (GO:0060046)5.52845775
21acute-phase response (GO:0006953)5.25381934
22sterol transport (GO:0015918)5.15974280
23cholesterol transport (GO:0030301)5.15974280
24intestinal epithelial cell development (GO:0060576)5.07065379
25COPI coating of Golgi vesicle (GO:0048205)5.02334204
26Golgi transport vesicle coating (GO:0048200)5.02334204
27polyketide metabolic process (GO:0030638)4.90673471
28doxorubicin metabolic process (GO:0044598)4.90673471
29daunorubicin metabolic process (GO:0044597)4.90673471
30digestive system process (GO:0022600)4.78390402
31maintenance of protein localization in organelle (GO:0072595)4.61740627
32GDP-mannose metabolic process (GO:0019673)4.60695347
33ceramide catabolic process (GO:0046514)4.56592611
34cellular modified amino acid catabolic process (GO:0042219)4.54217355
35maintenance of gastrointestinal epithelium (GO:0030277)4.49920640
36aminoglycoside antibiotic metabolic process (GO:0030647)4.43928403
37regulation of epidermal cell differentiation (GO:0045604)4.43798744
38mitochondrial calcium ion transport (GO:0006851)4.43701933
39negative regulation of epithelial cell differentiation (GO:0030857)4.40834253
40activation of signaling protein activity involved in unfolded protein response (GO:0006987)4.29919610
41serine family amino acid biosynthetic process (GO:0009070)4.24838465
42response to endoplasmic reticulum stress (GO:0034976)4.20202373
43aspartate family amino acid catabolic process (GO:0009068)4.19255048
44zinc ion transport (GO:0006829)4.17568969
45positive regulation of nuclease activity (GO:0032075)4.12907446
46positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003604.10197862
47positive regulation of wound healing (GO:0090303)4.07099505
48proline metabolic process (GO:0006560)4.04294473
49protein maturation by protein folding (GO:0022417)4.02987439
50phospholipid catabolic process (GO:0009395)4.01878813
51signal peptide processing (GO:0006465)3.94743301
52endoplasmic reticulum unfolded protein response (GO:0030968)3.92568284
534-hydroxyproline metabolic process (GO:0019471)3.88966995
54endothelial cell migration (GO:0043542)3.87482455
55homocysteine metabolic process (GO:0050667)3.86895874
56glutamine metabolic process (GO:0006541)3.82787650
57cellular response to unfolded protein (GO:0034620)3.80786639
58regulation of nuclease activity (GO:0032069)3.79545021
59regulation of oxidative stress-induced intrinsic apoptotic signaling pathway (GO:1902175)3.77307220
60regulation of cholesterol homeostasis (GO:2000188)3.77208126
61acute inflammatory response (GO:0002526)3.73939839
62positive regulation of growth hormone secretion (GO:0060124)3.69620311
63vitamin metabolic process (GO:0006766)3.64486450
64cellular response to topologically incorrect protein (GO:0035967)3.61646837
65steroid catabolic process (GO:0006706)3.61596348
66ER-nucleus signaling pathway (GO:0006984)3.58728939
67positive regulation of heat generation (GO:0031652)3.58485484
68coenzyme catabolic process (GO:0009109)3.58451607
69retinoid metabolic process (GO:0001523)3.57831346
70sulfation (GO:0051923)3.57359756
71pH reduction (GO:0045851)3.56752980
72biotin metabolic process (GO:0006768)3.52475524
73glutathione derivative biosynthetic process (GO:1901687)3.52049814
74glutathione derivative metabolic process (GO:1901685)3.52049814
75epithelial structure maintenance (GO:0010669)3.44416542
76growth hormone secretion (GO:0030252)3.43456370
77regulation of fever generation (GO:0031620)3.43056825
78L-serine metabolic process (GO:0006563)3.42925732
79serine family amino acid metabolic process (GO:0009069)3.40496163
80tetrapyrrole metabolic process (GO:0033013)3.38945386
81diterpenoid metabolic process (GO:0016101)3.37927714
82regulation of calcium ion import (GO:0090279)3.33412696
83cellular response to zinc ion (GO:0071294)3.32929362
84regulation of oxidative stress-induced cell death (GO:1903201)3.31470415
85sulfur amino acid catabolic process (GO:0000098)3.31104465
86protein autoprocessing (GO:0016540)3.30937977
87nucleotide-sugar biosynthetic process (GO:0009226)3.30186367
88O-glycan processing (GO:0016266)3.28359107
89atrioventricular valve morphogenesis (GO:0003181)3.28340305
90negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.27794753
91phototransduction, visible light (GO:0007603)3.27573652
92COPII vesicle coating (GO:0048208)3.26256923
93mitochondrion distribution (GO:0048311)3.25350049
94cellular response to cadmium ion (GO:0071276)3.24519142
95extracellular matrix disassembly (GO:0022617)3.20537576
96cholesterol metabolic process (GO:0008203)3.18041159
97polarized epithelial cell differentiation (GO:0030859)3.13564643
98ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)3.12010620
99response to unfolded protein (GO:0006986)3.10612291
100cell redox homeostasis (GO:0045454)3.09655624
101erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.08258933
102L-phenylalanine catabolic process (GO:0006559)3.08258933
103lung secretory cell differentiation (GO:0061140)3.08023738
104creatine metabolic process (GO:0006600)3.07650494
105peptidyl-proline modification (GO:0018208)3.06386877
106L-phenylalanine metabolic process (GO:0006558)3.04532698
107erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.04532698
108regulation of digestive system process (GO:0044058)3.02750328
109sphingolipid catabolic process (GO:0030149)3.01268841
110glycine metabolic process (GO:0006544)3.01146742
111negative regulation of cell fate commitment (GO:0010454)2.99396261
112regulation of macrophage chemotaxis (GO:0010758)2.99251595
113terpenoid metabolic process (GO:0006721)2.98725278
114response to topologically incorrect protein (GO:0035966)2.98680089
115negative regulation of epidermal cell differentiation (GO:0045605)2.96188234
116regulation of cellular response to oxidative stress (GO:1900407)2.95500019
117calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.95184441
118diacylglycerol metabolic process (GO:0046339)2.93313649
119negative regulation of transcription by competitive promoter binding (GO:0010944)2.92556030
120water-soluble vitamin metabolic process (GO:0006767)2.91932409
121retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.91782705
122purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.91251415
1233-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.91251415
124sulfur amino acid biosynthetic process (GO:0000097)2.90495981
125lysine metabolic process (GO:0006553)2.90031606
126lysine catabolic process (GO:0006554)2.90031606
127cellular glucuronidation (GO:0052695)2.89243867
128L-alpha-amino acid transmembrane transport (GO:1902475)2.88475266
129sterol metabolic process (GO:0016125)2.87895770
130epithelial cell migration (GO:0010631)2.87454889
131uronic acid metabolic process (GO:0006063)2.83395795
132glucuronate metabolic process (GO:0019585)2.83395795
133detection of visible light (GO:0009584)2.75683615
134regulation of epidermis development (GO:0045682)2.72671058
135negative regulation of hormone metabolic process (GO:0032351)2.72111082
136phototransduction (GO:0007602)2.58912785
137isoprenoid metabolic process (GO:0006720)2.58809520
138progesterone metabolic process (GO:0042448)2.57466884
139regulation of bile acid biosynthetic process (GO:0070857)2.53987464
140regulation of triglyceride catabolic process (GO:0010896)2.49671051
141endocrine pancreas development (GO:0031018)2.45414207
142alcohol catabolic process (GO:0046164)2.40855983
143regulation of calcium ion-dependent exocytosis (GO:0017158)2.37899376
144UDP-N-acetylglucosamine metabolic process (GO:0006047)2.34391971
145S-adenosylmethionine metabolic process (GO:0046500)2.31095311
146detection of light stimulus (GO:0009583)2.31027819
147glycoside metabolic process (GO:0016137)2.30594494
148epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.27992967
149primary alcohol catabolic process (GO:0034310)2.27250600
150regulation of metalloenzyme activity (GO:0048552)2.27192312
151water-soluble vitamin biosynthetic process (GO:0042364)2.22413807
152regulation of cellular extravasation (GO:0002691)2.20604760
153macroautophagy (GO:0016236)2.19466984
154* defense response to Gram-positive bacterium (GO:0050830)2.19333397
155organic hydroxy compound transport (GO:0015850)2.16790422
156retinal metabolic process (GO:0042574)2.12793084
157endocardial cushion morphogenesis (GO:0003203)2.10176507
158response to mercury ion (GO:0046689)2.09720281
159* multicellular organismal catabolic process (GO:0044243)2.07574133
160digestion (GO:0007586)16.2363396
161intestinal cholesterol absorption (GO:0030299)15.1744140
162exocrine pancreas development (GO:0031017)13.9972115
163protein retention in ER lumen (GO:0006621)13.1354017
164maintenance of protein localization in endoplasmic reticulum (GO:0035437)12.1693456
165negative regulation of epidermis development (GO:0045683)10.4964900

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat6.52670912
2STAT6_21828071_ChIP-Seq_BEAS2B_Human4.24865282
3SOX2_27498859_Chip-Seq_STOMACH_Mouse3.94023275
4ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.71192175
5CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human3.06150336
6* GATA4_25053715_ChIP-Seq_YYC3_Human2.86934776
7EGR1_19032775_ChIP-ChIP_M12_Human2.79293413
8ESR1_21235772_ChIP-Seq_MCF-7_Human2.73423410
9ERG_21242973_ChIP-ChIP_JURKAT_Human2.58161005
10GATA6_25053715_ChIP-Seq_YYC3_Human2.54222072
11PPARA_22158963_ChIP-Seq_LIVER_Mouse2.50456419
12ESR2_21235772_ChIP-Seq_MCF-7_Human2.39613309
13FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.38475934
14TCF4_18268006_ChIP-ChIP_LS174T_Human2.31186439
15RXR_22158963_ChIP-Seq_LIVER_Mouse2.21423677
16HTT_18923047_ChIP-ChIP_STHdh_Human2.18322149
17FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.13584108
18NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.07031036
19PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.04078277
20FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.02106762
21STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.01596007
22RARG_19884340_ChIP-ChIP_MEFs_Mouse1.97320200
23PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.95606476
24POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.91081298
25LXR_22158963_ChIP-Seq_LIVER_Mouse1.84377622
26ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.77234375
27HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.77117369
28AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.73632597
29LXR_22292898_ChIP-Seq_THP-1_Human1.72698787
30MYC_18555785_ChIP-Seq_MESCs_Mouse1.72409022
31NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.70207060
32PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.63902448
33ETV1_20927104_ChIP-Seq_GIST48_Human1.63777975
34SRY_22984422_ChIP-ChIP_TESTIS_Rat1.62712372
35FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.61089667
36TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.60514668
37HNFA_21074721_ChIP-Seq_CACO-2_Human1.57979537
38PHF8_20622853_ChIP-Seq_HELA_Human1.56937735
39MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.55447718
40EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.54381138
41IRF8_22096565_ChIP-ChIP_GC-B_Human1.53995869
42STAT3_1855785_ChIP-Seq_MESCs_Mouse1.53855249
43CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.51820298
44NFYA_21822215_ChIP-Seq_K562_Human1.51714699
45TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.51364724
46TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.51339746
47PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.51322124
48CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.50585484
49CBX2_22325352_ChIP-Seq_293T-Rex_Human1.47828577
50ESR1_15608294_ChIP-ChIP_MCF-7_Human1.45504580
51GATA1_22025678_ChIP-Seq_K562_Human1.45494543
52ZNF217_24962896_ChIP-Seq_MCF-7_Human1.45366501
53RBPJ_21746931_ChIP-Seq_IB4_Human1.44941740
54FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.44864481
55MYC_19079543_ChIP-ChIP_MESCs_Mouse1.42491489
56GATA6_21074721_ChIP-Seq_CACO-2_Human1.42158007
57GATA1_26923725_Chip-Seq_HPCs_Mouse1.41020996
58GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.40759186
59* FOXA1_25552417_ChIP-Seq_VCAP_Human1.38428713
60P63_26484246_Chip-Seq_KERATINOCYTES_Human1.37991001
61P68_20966046_ChIP-Seq_HELA_Human1.37061323
62ATF3_27146783_Chip-Seq_COLON_Human1.37016501
63IGF1R_20145208_ChIP-Seq_DFB_Human1.36159106
64SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.31629286
65SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.31089381
66SOX2_20726797_ChIP-Seq_SW620_Human1.30707573
67NFYB_21822215_ChIP-Seq_K562_Human1.30489525
68PPAR_26484153_Chip-Seq_NCI-H1993_Human1.28346901
69BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.27766728
70JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.27384504
71STAT1_20625510_ChIP-Seq_HELA_Human1.26780958
72GATA3_24758297_ChIP-Seq_MCF-7_Human1.25533639
73SALL4_18804426_ChIP-ChIP_XEN_Mouse1.25485424
74* SA1_27219007_Chip-Seq_ERYTHROID_Human1.23795138
75CHD1_26751641_Chip-Seq_LNCaP_Human1.22963405
76TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.22826777
77E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.21819453
78EGR1_23403033_ChIP-Seq_LIVER_Mouse1.19673326
79SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.19398111
80CDX2_19796622_ChIP-Seq_MESCs_Mouse1.19396589
81JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.19083144
82KLF5_25053715_ChIP-Seq_YYC3_Human1.17844213
83FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.17443585
84CJUN_26792858_Chip-Seq_BT549_Human1.17420696
85* BCOR_27268052_Chip-Seq_Bcells_Human1.16446503
86KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.16406252
87RACK7_27058665_Chip-Seq_MCF-7_Human1.15981191
88PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.15264226
89P300_19829295_ChIP-Seq_ESCs_Human1.14855471
90FOXM1_26456572_ChIP-Seq_MCF-7_Human1.13857336
91POU3F2_20337985_ChIP-ChIP_501MEL_Human1.13775882
92KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.12291752
93NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.12055169
94* CREB1_26743006_Chip-Seq_LNCaP_Human1.11760788
95NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.11569910
96SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.10585808
97PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.10320592
98MYC_18358816_ChIP-ChIP_MESCs_Mouse1.09338383
99RUNX1_27514584_Chip-Seq_MCF-7_Human1.09235951
100CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.08164917
101PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.07461354
102* KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.06415530
103* KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.06415530
104* KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.06415530
105FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.06050425
106TP63_22573176_ChIP-Seq_HFKS_Human1.04815141
107* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.04656457
108AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.04642205
109SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.04449255
110SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.03166181
111P53_21459846_ChIP-Seq_SAOS-2_Human1.03079669
112CEBPB_22108803_ChIP-Seq_LS180_Human1.01960759
113TBL1_22424771_ChIP-Seq_293T_Human1.01243784
114ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.00754008
115TP53_18474530_ChIP-ChIP_U2OS_Human1.00459148
116NANOG_21062744_ChIP-ChIP_HESCs_Human0.99378336
117CBP_21632823_ChIP-Seq_H3396_Human0.99368674
118CDX2_20551321_ChIP-Seq_CACO-2_Human0.98681804
119CDX2_22108803_ChIP-Seq_LS180_Human0.98506373
120FOXH1_21741376_ChIP-Seq_ESCs_Human0.98219078
121RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.98058955
122SMAD4_21741376_ChIP-Seq_EPCs_Human0.97935355
123* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.96611361
124ELK4_26923725_Chip-Seq_MESODERM_Mouse0.96446655
125ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.96206999
126FOXA1_21572438_ChIP-Seq_LNCaP_Human0.96146294
127FOXP1_21924763_ChIP-Seq_HESCs_Human0.95482555
128IRF1_19129219_ChIP-ChIP_H3396_Human0.94979325
129* CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.94565801
130PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.94514179
131ETS1_20019798_ChIP-Seq_JURKAT_Human0.93540945
132RARA_24833708_ChIP-Seq_LIVER_Mouse0.92965600
133OCT4_20526341_ChIP-Seq_ESCs_Human0.92666728
134* FOXO3_23340844_ChIP-Seq_DLD1_Human0.92639748
135ESET_19884257_ChIP-Seq_ESCs_Mouse0.91452657
136MYC_19829295_ChIP-Seq_ESCs_Human0.90812555
137SMAD_19615063_ChIP-ChIP_OVARY_Human0.90793389
138SOX3_22085726_ChIP-Seq_MUSCLE_Mouse0.90758859
139TAF15_26573619_Chip-Seq_HEK293_Human0.90459815
140SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.90128386
141CTCF_20526341_ChIP-Seq_ESCs_Human0.89946413
142CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.89220311
143FOXA2_19822575_ChIP-Seq_HepG2_Human0.89058405
144TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.88182774
145SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.87998798
146NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.87874640
147SOX2_19829295_ChIP-Seq_ESCs_Human0.87283447
148NANOG_19829295_ChIP-Seq_ESCs_Human0.87283447
149CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.86230224
150PIAS1_25552417_ChIP-Seq_VCAP_Human0.84947100
151ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.84923026
152CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.83761523
153FOXH1_21741376_ChIP-Seq_EPCs_Human0.82425220
154NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.82004660
155NRF2_20460467_ChIP-Seq_MEFs_Mouse0.82004660
156KLF5_20875108_ChIP-Seq_MESCs_Mouse0.80978216
157TAF2_19829295_ChIP-Seq_ESCs_Human0.80530724
158SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.78724150
159ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.78306688
160CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.78169256
161EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.77675655
162CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.76410897
163CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.75876308
164SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.75678767
165SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.74745087
166SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.74745087
167ZFP57_27257070_Chip-Seq_ESCs_Mouse0.73129297
168CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.72919710
169RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.70548650
170ETV2_25802403_ChIP-Seq_MESCs_Mouse0.70395488

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008004_abnormal_stomach_pH9.93762071
2MP0005083_abnormal_biliary_tract8.61659931
3* MP0001666_abnormal_nutrient_absorption7.40616317
4MP0005365_abnormal_bile_salt5.22822653
5MP0005220_abnormal_exocrine_pancreas4.93077542
6MP0003868_abnormal_feces_composition4.88401183
7MP0001664_abnormal_digestion4.40651272
8MP0005084_abnormal_gallbladder_morpholo3.55155294
9MP0005085_abnormal_gallbladder_physiolo3.24589120
10MP0000470_abnormal_stomach_morphology3.13222748
11MP0003806_abnormal_nucleotide_metabolis2.55795005
12MP0001873_stomach_inflammation2.52740712
13MP0010386_abnormal_urinary_bladder2.46492578
14MP0003959_abnormal_lean_body1.92533755
15MP0002693_abnormal_pancreas_physiology1.91006985
16MP0004264_abnormal_extraembryonic_tissu1.79389328
17MP0003705_abnormal_hypodermis_morpholog1.73201997
18MP0003300_gastrointestinal_ulcer1.62252079
19MP0005165_increased_susceptibility_to1.61407023
20MP0010234_abnormal_vibrissa_follicle1.52106530
21MP0003195_calcinosis1.43265067
22MP0009780_abnormal_chondrocyte_physiolo1.37008440
23MP0002139_abnormal_hepatobiliary_system1.33993502
24MP0002277_abnormal_respiratory_mucosa1.33658651
25MP0004233_abnormal_muscle_weight1.31569106
26MP0005448_abnormal_energy_balance1.22132687
27MP0001944_abnormal_pancreas_morphology1.15636864
28MP0003638_abnormal_response/metabolism_1.12896686
29MP0001663_abnormal_digestive_system1.11206426
30MP0003186_abnormal_redox_activity1.10110820
31MP0002132_abnormal_respiratory_system1.07812554
32MP0003011_delayed_dark_adaptation1.07015687
33MP0000490_abnormal_crypts_of1.05772121
34* MP0002118_abnormal_lipid_homeostasis1.04818569
35MP0005332_abnormal_amino_acid1.02374050
36MP0002138_abnormal_hepatobiliary_system0.94099074
37MP0005381_digestive/alimentary_phenotyp0.93750885
38MP0009840_abnormal_foam_cell0.90324685
39MP0003943_abnormal_hepatobiliary_system0.85655911
40MP0009384_cardiac_valve_regurgitation0.85345595
41MP0005451_abnormal_body_composition0.81977419
42MP0010329_abnormal_lipoprotein_level0.81256616
43MP0003950_abnormal_plasma_membrane0.79017848
44MP0003045_fibrosis0.78509362
45MP0005408_hypopigmentation0.78276009
46MP0006054_spinal_hemorrhage0.77634052
47MP0001502_abnormal_circadian_rhythm0.76142916
48MP0002163_abnormal_gland_morphology0.74640496
49MP0002909_abnormal_adrenal_gland0.70482805
50MP0003252_abnormal_bile_duct0.69688296
51* MP0003953_abnormal_hormone_level0.66873448
52MP0009643_abnormal_urine_homeostasis0.64860921
53MP0002796_impaired_skin_barrier0.64747799
54* MP0002078_abnormal_glucose_homeostasis0.64587539
55MP0003283_abnormal_digestive_organ0.63978125
56MP0010678_abnormal_skin_adnexa0.62432317
57MP0000003_abnormal_adipose_tissue0.60761661
58MP0008438_abnormal_cutaneous_collagen0.60624196
59MP0001501_abnormal_sleep_pattern0.60558942
60MP0008789_abnormal_olfactory_epithelium0.58688767
61MP0006036_abnormal_mitochondrial_physio0.58289191
62MP0008995_early_reproductive_senescence0.54836801
63MP0004185_abnormal_adipocyte_glucose0.50772254
64* MP0005452_abnormal_adipose_tissue0.50503105
65MP0000613_abnormal_salivary_gland0.49348958
66MP0005319_abnormal_enzyme/_coenzyme0.48762236
67MP0005379_endocrine/exocrine_gland_phen0.48092970
68MP0004043_abnormal_pH_regulation0.44518193
69MP0005266_abnormal_metabolism0.44379374
70MP0005535_abnormal_body_temperature0.44248722
71MP0005499_abnormal_olfactory_system0.43452162
72MP0005394_taste/olfaction_phenotype0.43452162
73MP0004019_abnormal_vitamin_homeostasis0.42130429
74MP0000367_abnormal_coat/_hair0.41723556
75MP0008961_abnormal_basal_metabolism0.41367668
76MP0001764_abnormal_homeostasis0.41319061
77MP0000750_abnormal_muscle_regeneration0.39875083
78MP0005636_abnormal_mineral_homeostasis0.39687842
79* MP0000598_abnormal_liver_morphology0.39076831
80MP0002060_abnormal_skin_morphology0.37679082
81MP0003879_abnormal_hair_cell0.37409150
82MP0001731_abnormal_postnatal_growth0.37180960
83MP0002098_abnormal_vibrissa_morphology0.37032982
84MP0000477_abnormal_intestine_morphology0.36170903
85MP0009765_abnormal_xenobiotic_induced0.35694993
86MP0000371_diluted_coat_color0.35494202
87MP0000609_abnormal_liver_physiology0.34716585
88MP0008875_abnormal_xenobiotic_pharmacok0.34545734
89MP0005058_abnormal_lysosome_morphology0.34210774
90MP0001765_abnormal_ion_homeostasis0.33546329
91MP0001845_abnormal_inflammatory_respons0.33166884
92MP0000467_abnormal_esophagus_morphology0.32914423
93MP0001243_abnormal_dermal_layer0.32768793
94MP0003693_abnormal_embryo_hatching0.32355311
95MP0002168_other_aberrant_phenotype0.31191882
96MP0005375_adipose_tissue_phenotype0.29087743
97MP0002876_abnormal_thyroid_physiology0.28481665
98* MP0009642_abnormal_blood_homeostasis0.27950530
99MP0005166_decreased_susceptibility_to0.27942417
100MP0003119_abnormal_digestive_system0.27681687
101MP0002837_dystrophic_cardiac_calcinosis0.27071621
102MP0003656_abnormal_erythrocyte_physiolo0.26998490
103MP0004133_heterotaxia0.26516811
104MP0002069_abnormal_eating/drinking_beha0.26357489
105MP0002089_abnormal_postnatal_growth/wei0.26076372
106MP0000537_abnormal_urethra_morphology0.26054260
107MP0005360_urolithiasis0.26017618
108MP0005595_abnormal_vascular_smooth0.25732881
109MP0000383_abnormal_hair_follicle0.25462131
110MP0002928_abnormal_bile_duct0.25276667
111MP0000538_abnormal_urinary_bladder0.25152845
112MP0008770_decreased_survivor_rate0.25111837
113MP0008872_abnormal_physiological_respon0.24747384
114MP0000377_abnormal_hair_follicle0.24299306
115MP0003191_abnormal_cellular_cholesterol0.23566338
116MP0010352_gastrointestinal_tract_polyps0.23252688
117MP0003329_amyloid_beta_deposits0.21771790
118MP0003453_abnormal_keratinocyte_physiol0.21692794
119MP0009763_increased_sensitivity_to0.21602239
120MP0003436_decreased_susceptibility_to0.21485048
121MP0009333_abnormal_splenocyte_physiolog0.20885489
122MP0005646_abnormal_pituitary_gland0.20562688
123MP0002136_abnormal_kidney_physiology0.20352467
124MP0000858_altered_metastatic_potential0.20255261
125MP0001756_abnormal_urination0.20255206
126MP0003828_pulmonary_edema0.20127340
127MP0002295_abnormal_pulmonary_circulatio0.20087673
128MP0001849_ear_inflammation0.19518407
129MP0005501_abnormal_skin_physiology0.19264874
130MP0005410_abnormal_fertilization0.19106400
131MP0009931_abnormal_skin_appearance0.19082877
132MP0003866_abnormal_defecation0.18988780
133MP0000462_abnormal_digestive_system0.18794070
134MP0003941_abnormal_skin_development0.18384702
135MP0010155_abnormal_intestine_physiology0.18064927
136MP0000920_abnormal_myelination0.17865900
137MP0003566_abnormal_cell_adhesion0.17111431
138MP0004484_altered_response_of0.16823684
139MP0001485_abnormal_pinna_reflex0.16539284
140MP0003795_abnormal_bone_structure0.16223503
141MP0005164_abnormal_response_to0.16079209
142MP0004957_abnormal_blastocyst_morpholog0.15269477
143MP0008469_abnormal_protein_level0.14553531

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)9.61782777
2Gout (HP:0001997)7.07196049
3Steatorrhea (HP:0002570)6.73017692
4Megaloblastic anemia (HP:0001889)6.09563364
5Fat malabsorption (HP:0002630)5.61936990
6Abnormality of the vitamin B12 metabolism (HP:0004341)5.21278949
7Short chin (HP:0000331)5.17046319
8Abnormality of vitamin B metabolism (HP:0004340)4.96029990
9Decreased subcutaneous fat (HP:0001002)4.67588080
10Abnormality of the pleura (HP:0002103)4.52960438
11Tubulointerstitial nephritis (HP:0001970)4.42108237
12Type I diabetes mellitus (HP:0100651)4.25366625
13Abnormality of subcutaneous fat tissue (HP:0001001)4.24748595
14Maternal diabetes (HP:0009800)4.16601479
15Abnormality of vitamin metabolism (HP:0100508)4.06076902
16Hypoplasia of the pons (HP:0012110)4.05685487
17Exocrine pancreatic insufficiency (HP:0001738)3.79166577
18Abnormality of the pons (HP:0007361)3.79157775
19Tubulointerstitial fibrosis (HP:0005576)3.72717975
20Cortical dysplasia (HP:0002539)3.71430187
21Abnormality of the intrinsic pathway (HP:0010989)3.65901658
22Ketosis (HP:0001946)3.54346702
23Pancreatitis (HP:0001733)3.50043485
24Carpal bone hypoplasia (HP:0001498)3.48390587
25Increased purine levels (HP:0004368)3.45020237
26Hyperuricemia (HP:0002149)3.45020237
27Hyperglycinemia (HP:0002154)3.38942913
28Ketoacidosis (HP:0001993)3.33556555
29Right ventricular cardiomyopathy (HP:0011663)3.24234461
30Premature skin wrinkling (HP:0100678)3.22117496
31Hyperglycinuria (HP:0003108)3.18866683
32Long foot (HP:0001833)3.16739077
33Abnormality of aromatic amino acid family metabolism (HP:0004338)3.09125841
34Ventricular fibrillation (HP:0001663)3.08194182
35Joint stiffness (HP:0001387)3.02872443
36Anal atresia (HP:0002023)2.96318013
37Abnormal pancreas size (HP:0012094)2.94732074
38Renal salt wasting (HP:0000127)2.88978630
39Macrocytic anemia (HP:0001972)2.85563809
40Abnormality of serine family amino acid metabolism (HP:0010894)2.83442026
41Abnormality of glycine metabolism (HP:0010895)2.83442026
42Cardiovascular calcification (HP:0011915)2.83002809
43Tubular atrophy (HP:0000092)2.71441549
44Tetraparesis (HP:0002273)2.50884989
45Large for gestational age (HP:0001520)2.49590646
46Abnormality of sulfur amino acid metabolism (HP:0004339)2.48848309
47Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.39916368
48Hypoglycemic coma (HP:0001325)2.36703850
49Prenatal maternal abnormality (HP:0002686)2.36272549
50Abnormality of the renal cortex (HP:0011035)2.31592984
51Abnormality of the nasal septum (HP:0000419)2.31110687
52Hypoproteinemia (HP:0003075)2.29667388
53Progressive muscle weakness (HP:0003323)2.29179407
54Abnormality of endocrine pancreas physiology (HP:0012093)2.28959107
55Abnormality of the pancreatic islet cells (HP:0006476)2.28959107
56Abnormal tarsal ossification (HP:0008369)2.27237612
57Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.17983230
58Abnormal protein N-linked glycosylation (HP:0012347)2.17983230
59Abnormal protein glycosylation (HP:0012346)2.17983230
60Abnormal glycosylation (HP:0012345)2.17983230
61Optic nerve hypoplasia (HP:0000609)2.17206952
62Sex reversal (HP:0012245)2.17023255
63Abnormal sex determination (HP:0012244)2.17023255
64Abnormality of purine metabolism (HP:0004352)2.16595064
65Lethargy (HP:0001254)2.15211716
66Syncope (HP:0001279)2.11869125
67Hyperammonemia (HP:0001987)2.09263200
68Prolonged QT interval (HP:0001657)2.07870571
69Glomerulosclerosis (HP:0000096)2.07864019
70Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.07626201
71Tubulointerstitial abnormality (HP:0001969)2.04518300
72Malnutrition (HP:0004395)2.03557611
73Abnormal number of erythroid precursors (HP:0012131)10.4249274
74Popliteal pterygium (HP:0009756)1.99203976
75Vacuolated lymphocytes (HP:0001922)1.98035574
76Type I transferrin isoform profile (HP:0003642)1.97974993
77Opisthotonus (HP:0002179)1.97968761
78Abnormality of the common coagulation pathway (HP:0010990)1.97953367
79Cortical visual impairment (HP:0100704)1.94538263
80Ankyloglossia (HP:0010296)1.93459221
81Pectus carinatum (HP:0000768)1.92532271
82Male infertility (HP:0003251)1.92069423
83Methylmalonic aciduria (HP:0012120)1.89463700
84Acute hepatic failure (HP:0006554)1.89461182
85Reduced antithrombin III activity (HP:0001976)1.88503697
86Small epiphyses (HP:0010585)1.87477074
87Ileus (HP:0002595)1.87372663
88Acute encephalopathy (HP:0006846)1.85968446
89Rectal prolapse (HP:0002035)1.85031325
90Dicarboxylic aciduria (HP:0003215)1.84924933
91Abnormality of dicarboxylic acid metabolism (HP:0010995)1.84924933
92Cerebral edema (HP:0002181)1.83616956
93Abnormality of methionine metabolism (HP:0010901)1.82862113
94Esophageal varix (HP:0002040)1.81127489
95Fatigue (HP:0012378)1.78271461
96Hypoplasia of the odontoid process (HP:0003311)1.76684283
97Large hands (HP:0001176)1.75725462
98Abnormality of proline metabolism (HP:0010907)1.75454159
99Hydroxyprolinuria (HP:0003080)1.75454159
100Abnormal biliary tract morphology (HP:0012440)1.75081112
101Methylmalonic acidemia (HP:0002912)1.74124423
102Multiple enchondromatosis (HP:0005701)1.72527318
103Intrahepatic cholestasis (HP:0001406)1.72398623
104Abdominal pain (HP:0002027)1.72338959
105Late onset (HP:0003584)1.72021931
106Stenosis of the external auditory canal (HP:0000402)1.71805856
107Barrel-shaped chest (HP:0001552)1.70331434
108Congenital, generalized hypertrichosis (HP:0004540)1.68806949
109Congenital glaucoma (HP:0001087)1.67972916
110Redundant skin (HP:0001582)1.67141293
111Abnormality of fatty-acid metabolism (HP:0004359)1.65839290
112Abnormal hemoglobin (HP:0011902)1.65722307
113Hyperinsulinemic hypoglycemia (HP:0000825)1.65367596
114Abnormal foot bone ossification (HP:0010675)1.64994764
115Flat acetabular roof (HP:0003180)1.64092879
116Goiter (HP:0000853)1.63617074
117Limb hypertonia (HP:0002509)1.63506475
118Abnormality of aspartate family amino acid metabolism (HP:0010899)1.62771168
119Hypoglycemic seizures (HP:0002173)1.62327129
120Insulin-resistant diabetes mellitus (HP:0000831)1.61553559
121Vascular calcification (HP:0004934)1.60236580
122Arterial tortuosity (HP:0005116)1.59707158
123Homocystinuria (HP:0002156)1.58679738
124Abnormality of homocysteine metabolism (HP:0010919)1.58679738
125Lower limb hyperreflexia (HP:0002395)1.56814200
126Vascular tortuosity (HP:0004948)1.47648019
127Facial shape deformation (HP:0011334)1.45126076
128Potter facies (HP:0002009)1.45126076
129Glomerulonephritis (HP:0000099)1.44697080
130Hyperphosphatemia (HP:0002905)1.43102977
131Abnormality of glutamine family amino acid metabolism (HP:0010902)1.42428222
132Increased CSF protein (HP:0002922)1.41873485
133Absent eyebrow (HP:0002223)1.41543034
134Paraparesis (HP:0002385)1.40345038
135Double outlet right ventricle (HP:0001719)1.38700065
136Congenital malformation of the right heart (HP:0011723)1.38700065
137Abnormality of urine glucose concentration (HP:0011016)1.38488767
138Glycosuria (HP:0003076)1.38488767
139Neoplasm of the pancreas (HP:0002894)1.36390936
140Abnormal cartilage morphology (HP:0002763)1.35021079
141Portal hypertension (HP:0001409)1.34834424
142Glossoptosis (HP:0000162)1.33086018
143Preauricular pit (HP:0004467)1.32746813
144Periauricular skin pits (HP:0100277)1.32746813
145Bifid uvula (HP:0000193)1.29282219
146Villous atrophy (HP:0011473)1.28555912
147Abnormality of small intestinal villus morphology (HP:0011472)1.28555912
148Unilateral renal agenesis (HP:0000122)1.26068338
149Enlarged kidneys (HP:0000105)1.23930398
150Hyperglycemia (HP:0003074)1.22952919
151Skin pits (HP:0100276)1.21942636
152Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.21294711
153Azoospermia (HP:0000027)1.21103898
154Abnormality of the hepatic vasculature (HP:0006707)1.20280056
155Aplasia/hypoplasia of the uterus (HP:0008684)1.15847596
156Volvulus (HP:0002580)1.15790217
157Genetic anticipation (HP:0003743)1.15519729
158Congenital sensorineural hearing impairment (HP:0008527)1.14576316
159Type II lissencephaly (HP:0007260)1.14506776

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN14.91698705
2EPHA24.14629349
3EIF2AK34.02585346
4MAP2K23.62340883
5TRIB33.28381141
6PKN23.19496285
7GRK12.60534512
8MAPKAPK32.47709484
9ZAP702.22720638
10MAP3K122.18205765
11MST1R2.00658017
12BCKDK10.3355126
13OXSR11.96272897
14MST41.86520513
15PIK3CG1.84479191
16FRK1.82489953
17EPHA31.81974826
18STK161.71720811
19RPS6KB21.71082361
20NME21.70946660
21NTRK31.66399704
22MAP2K11.62633590
23PAK21.60351605
24NME11.54384557
25IRAK11.52220840
26PDK21.51725507
27NLK1.45970681
28TGFBR21.42250541
29WNK41.42172538
30PDGFRB1.35850714
31LRRK21.35465997
32STK241.34927728
33SCYL21.33765908
34PRKG21.28800984
35INSRR1.27001825
36IRAK31.22836408
37STK38L1.14647165
38BMPR1B1.14642678
39PRKCI1.09570037
40MET1.08329530
41EEF2K1.06753970
42PASK1.02153074
43RIPK11.01502308
44FLT31.01108018
45SGK20.99442688
46KSR20.97045431
47PTK60.94723623
48TRPM70.94302597
49SGK30.93886517
50DYRK1A0.93801213
51MAP2K60.92360591
52MAP3K70.91760629
53MYLK0.90735480
54BRSK20.87542128
55PRKCE0.87204901
56MAPK150.81499566
57PIK3CA0.81290591
58MAP3K140.81126279
59STK390.78405369
60PDK40.73347758
61PDK30.73347758
62MAP3K90.72162318
63MAP3K20.70817971
64SGK2230.70537313
65SGK4940.70537313
66CDK80.70043503
67LATS10.69004580
68STK100.68614431
69DDR20.64952069
70TRIM280.62476521
71MAP3K80.61703634
72MTOR0.61200267
73ERBB30.60429409
74EPHB10.59948772
75MELK0.59302488
76STK30.58714510
77TBK10.57645060
78MAP3K50.56733380
79FGFR30.56305864
80DYRK1B0.53656106
81PINK10.53414612
82TAOK30.52774328
83FER0.51280638
84STK380.50995495
85ROCK10.49901013
86PDPK10.48605670
87EIF2AK10.46737797
88JAK10.46384899
89CASK0.46070415
90CAMKK10.44265236
91MUSK0.41198280
92PRKAA10.40886447
93RPS6KB10.39911016
94SIK10.39335938
95MATK0.38598156
96PDK10.37669141
97MAPK120.37437934
98CHUK0.37204271
99NEK60.36659854
100DAPK20.36634172
101PRKCQ0.35935074
102RPS6KA10.35196021
103ICK0.34737822
104RET0.34692641
105IRAK20.34335835
106MAPK70.32896291
107PRKACB0.32572304
108TYRO30.31957468
109ACVR1B0.31084504
110PRKCZ0.30985770
111BCR0.30932378
112PRKAA20.30883739
113DAPK30.29811944
114NEK10.29728293
115HIPK20.28972382
116ILK0.28439875
117NUAK10.27331270
118MAP3K30.27271276
119ADRBK20.27219986
120NEK90.26839765
121SRPK10.25515164
122DYRK20.25150743
123CSNK1A10.24605028
124CAMKK20.24543224
125CSNK1G10.24505050
126LMTK20.23486403
127MAPK30.22552923
128CAMK40.22248346
129PTK20.22040719
130SGK10.21956184
131EGFR0.21851242
132DAPK10.21803229
133CDC42BPA0.21046711
134TESK10.19476479
135MAP3K10.18758713
136TIE10.18406617
137ROCK20.18048578
138YES10.18022819
139ABL10.17455121
140PRKACA0.17223594
141CSNK1E0.17090913
142NTRK10.17075328
143PIM20.16790900
144FGFR40.16730947
145PAK30.15863091
146ERBB40.15211864
147RPS6KA20.14077192
148MAPK10.13849868
149JAK20.13339915
150IRAK40.12056370
151BMX0.11775191
152CSK0.10477421
153IGF1R0.10005023
154CDK190.09821307
155PAK40.09683448
156AKT20.07873979
157CDK40.07152320
158PRKD10.06627970
159PDGFRA0.06155662
160AKT10.05892157
161RPS6KL10.05656946
162RPS6KC10.05656946

Predicted pathways (KEGG)

RankGene SetZ-score
1* Pancreatic secretion_Homo sapiens_hsa049727.23636845
2* Fat digestion and absorption_Homo sapiens_hsa049755.49983711
3Protein digestion and absorption_Homo sapiens_hsa049744.70204958
4Vitamin digestion and absorption_Homo sapiens_hsa049773.64859326
5Collecting duct acid secretion_Homo sapiens_hsa049663.47186010
6Glycerolipid metabolism_Homo sapiens_hsa005613.02551846
7Protein export_Homo sapiens_hsa030602.76839007
8Folate biosynthesis_Homo sapiens_hsa007902.74341539
9Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.61937556
10Cyanoamino acid metabolism_Homo sapiens_hsa004602.49525273
11Maturity onset diabetes of the young_Homo sapiens_hsa049502.44202581
12Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.31666550
13Gastric acid secretion_Homo sapiens_hsa049712.22047791
14Propanoate metabolism_Homo sapiens_hsa006402.13037711
15Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.91158111
162-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.88439115
17Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.74102743
18Steroid biosynthesis_Homo sapiens_hsa001001.48725747
19Glutathione metabolism_Homo sapiens_hsa004801.45657709
20Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.29466571
21Biosynthesis of amino acids_Homo sapiens_hsa012301.26654143
22Chemical carcinogenesis_Homo sapiens_hsa052041.23247949
23Renin-angiotensin system_Homo sapiens_hsa046141.13006758
24Oxidative phosphorylation_Homo sapiens_hsa001901.12680001
25Sulfur metabolism_Homo sapiens_hsa009201.12449429
26Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.10568555
27Arginine and proline metabolism_Homo sapiens_hsa003301.09984368
28Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.07349964
29Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.05173549
30Cysteine and methionine metabolism_Homo sapiens_hsa002701.04412969
31Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.03142700
32Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.02815527
33Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.97914443
34Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.93892609
35Circadian rhythm_Homo sapiens_hsa047100.92880221
36One carbon pool by folate_Homo sapiens_hsa006700.91577875
37Fatty acid degradation_Homo sapiens_hsa000710.88919772
38beta-Alanine metabolism_Homo sapiens_hsa004100.86819950
39Other glycan degradation_Homo sapiens_hsa005110.83564264
40Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.80964474
41Selenocompound metabolism_Homo sapiens_hsa004500.80279203
42Pyruvate metabolism_Homo sapiens_hsa006200.76956778
43Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.76403855
44Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.70246561
45N-Glycan biosynthesis_Homo sapiens_hsa005100.69720047
46Starch and sucrose metabolism_Homo sapiens_hsa005000.66986652
47Carbon metabolism_Homo sapiens_hsa012000.66248571
48Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.66016304
49Vitamin B6 metabolism_Homo sapiens_hsa007500.65904215
50Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.64523650
51Influenza A_Homo sapiens_hsa051640.59057230
52Steroid hormone biosynthesis_Homo sapiens_hsa001400.57490445
53Fructose and mannose metabolism_Homo sapiens_hsa000510.56904887
54Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.55552031
55Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.52839461
56Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.52533659
57Arginine biosynthesis_Homo sapiens_hsa002200.50249369
58Notch signaling pathway_Homo sapiens_hsa043300.48807921
59Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.48585070
60Primary bile acid biosynthesis_Homo sapiens_hsa001200.48536849
61Vibrio cholerae infection_Homo sapiens_hsa051100.44160135
62Parkinsons disease_Homo sapiens_hsa050120.42058566
63Ribosome_Homo sapiens_hsa030100.40703169
64Sulfur relay system_Homo sapiens_hsa041220.39524090
65* Metabolic pathways_Homo sapiens_hsa011000.37360694
66Tryptophan metabolism_Homo sapiens_hsa003800.34869607
67Histidine metabolism_Homo sapiens_hsa003400.33797853
68Insulin secretion_Homo sapiens_hsa049110.33731909
69Carbohydrate digestion and absorption_Homo sapiens_hsa049730.32426757
70Alzheimers disease_Homo sapiens_hsa050100.31135211
71Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.31000608
72Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.30515056
73Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.30322773
74Thyroid hormone synthesis_Homo sapiens_hsa049180.28769861
75Legionellosis_Homo sapiens_hsa051340.28071574
76Nitrogen metabolism_Homo sapiens_hsa009100.27734979
77Fatty acid metabolism_Homo sapiens_hsa012120.26887745
78Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.25961791
79Complement and coagulation cascades_Homo sapiens_hsa046100.25906906
80Bile secretion_Homo sapiens_hsa049760.23699045
81Hepatitis C_Homo sapiens_hsa051600.23582651
82Sphingolipid metabolism_Homo sapiens_hsa006000.21754186
83Lysosome_Homo sapiens_hsa041420.21455386
84Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.21144533
85Phenylalanine metabolism_Homo sapiens_hsa003600.20649489
86Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.20579091
87Jak-STAT signaling pathway_Homo sapiens_hsa046300.18152269
88Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.15546578
89Phototransduction_Homo sapiens_hsa047440.14886577
90Peroxisome_Homo sapiens_hsa041460.14870433
91VEGF signaling pathway_Homo sapiens_hsa043700.12198606
92Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.11854221
93Endometrial cancer_Homo sapiens_hsa052130.10711732
94Galactose metabolism_Homo sapiens_hsa000520.10326537
95Butanoate metabolism_Homo sapiens_hsa006500.10139900
96TGF-beta signaling pathway_Homo sapiens_hsa043500.09906293
97Adherens junction_Homo sapiens_hsa045200.08736050
98SNARE interactions in vesicular transport_Homo sapiens_hsa041300.08217937
99Tight junction_Homo sapiens_hsa045300.07949192
100Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.07194779
101Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.06405458
102Regulation of autophagy_Homo sapiens_hsa041400.05580533
103* alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.04122419
104Huntingtons disease_Homo sapiens_hsa050160.03791639
105Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.02762374
106FoxO signaling pathway_Homo sapiens_hsa040680.02098270
107ABC transporters_Homo sapiens_hsa020100.02040100
108Pentose phosphate pathway_Homo sapiens_hsa000300.01776087
109Ovarian steroidogenesis_Homo sapiens_hsa049130.01217741
110Mineral absorption_Homo sapiens_hsa049780.00954481
111Bladder cancer_Homo sapiens_hsa052190.00949563
112TNF signaling pathway_Homo sapiens_hsa046680.00710538
113Epstein-Barr virus infection_Homo sapiens_hsa05169-0.1072403
114AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933-0.1031955
115Proteasome_Homo sapiens_hsa03050-0.1028609
116HIF-1 signaling pathway_Homo sapiens_hsa04066-0.0996020
117Hippo signaling pathway_Homo sapiens_hsa04390-0.0936599
118NOD-like receptor signaling pathway_Homo sapiens_hsa04621-0.0918149
119Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960-0.0903555
120Insulin resistance_Homo sapiens_hsa04931-0.0886708
121Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514-0.0748930
122Rheumatoid arthritis_Homo sapiens_hsa05323-0.0641863
123Dorso-ventral axis formation_Homo sapiens_hsa04320-0.0571229
124Drug metabolism - other enzymes_Homo sapiens_hsa00983-0.0461551
125Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.0418685
126Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120-0.0368124
127Leukocyte transendothelial migration_Homo sapiens_hsa04670-0.0363099
128Pentose and glucuronate interconversions_Homo sapiens_hsa00040-0.0359516
129Retinol metabolism_Homo sapiens_hsa00830-0.0353496
130Tyrosine metabolism_Homo sapiens_hsa00350-0.0324500
131* Arachidonic acid metabolism_Homo sapiens_hsa00590-0.0322637
132Calcium signaling pathway_Homo sapiens_hsa04020-0.0318263
133Thyroid cancer_Homo sapiens_hsa05216-0.0300557
134mTOR signaling pathway_Homo sapiens_hsa04150-0.0242816
135Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524-0.0186447
136Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080-0.0107661

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