PLA2G2A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the phospholipase A2 family (PLA2). PLA2s constitute a diverse family of enzymes with respect to sequence, function, localization, and divalent cation requirements. This gene product belongs to group II, which contains secreted form of PLA2, an extracellular enzyme that has a low molecular mass and requires calcium ions for catalysis. It catalyzes the hydrolysis of the sn-2 fatty acid acyl ester bond of phosphoglycerides, releasing free fatty acids and lysophospholipids, and thought to participate in the regulation of the phospholipid metabolism in biomembranes. Several alternatively spliced transcript variants with different 5' UTRs have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of glucose import in response to insulin stimulus (GO:2001273)9.93851995
2lung secretory cell differentiation (GO:0061140)9.59419998
3positive regulation of cellular response to insulin stimulus (GO:1900078)8.12292614
4maintenance of gastrointestinal epithelium (GO:0030277)8.11813602
5regulation of norepinephrine secretion (GO:0014061)7.75462840
6hepatocyte apoptotic process (GO:0097284)7.20960023
7sulfation (GO:0051923)6.85306638
8regulation of guanylate cyclase activity (GO:0031282)6.78556223
9glandular epithelial cell differentiation (GO:0002067)6.63041919
10regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)6.55713872
11regulation of cellular extravasation (GO:0002691)6.15912562
12epithelial structure maintenance (GO:0010669)6.11513764
13NADH metabolic process (GO:0006734)5.92652138
14bile acid metabolic process (GO:0008206)5.90167925
15mucosal immune response (GO:0002385)5.66932892
16complement activation, classical pathway (GO:0006958)5.53255943
17intestinal absorption (GO:0050892)5.49768221
18positive regulation of pseudopodium assembly (GO:0031274)5.46889684
19antibacterial humoral response (GO:0019731)5.44706777
20negative regulation of cell fate commitment (GO:0010454)5.42242923
21pyrimidine-containing compound transmembrane transport (GO:0072531)5.38323402
22organ or tissue specific immune response (GO:0002251)5.37229714
23antimicrobial humoral response (GO:0019730)5.32653601
24positive regulation of guanylate cyclase activity (GO:0031284)5.30868520
25positive regulation of respiratory burst (GO:0060267)5.29914208
26regulation of hormone biosynthetic process (GO:0046885)5.11093279
27positive regulation of cytokine production involved in immune response (GO:0002720)5.04984718
28bundle of His cell to Purkinje myocyte communication (GO:0086069)5.02731159
29calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)4.96064828
30regulation of pseudopodium assembly (GO:0031272)4.93337955
31glomerular filtration (GO:0003094)4.78780524
32epoxygenase P450 pathway (GO:0019373)4.75090911
33galactose metabolic process (GO:0006012)4.71303545
34complement activation (GO:0006956)4.57722580
35regulation of cytokine secretion involved in immune response (GO:0002739)4.54179589
36regulation of bile acid biosynthetic process (GO:0070857)4.53352019
37digestive system process (GO:0022600)4.51732143
38positive regulation of glucose import (GO:0046326)4.50636865
39regulation of systemic arterial blood pressure by hormone (GO:0001990)4.42219833
40regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)4.42219833
41endocrine process (GO:0050886)4.42219833
42fat-soluble vitamin biosynthetic process (GO:0042362)4.41356514
43O-glycan processing (GO:0016266)4.37839088
44lung cell differentiation (GO:0060479)4.35879131
45lung epithelial cell differentiation (GO:0060487)4.31967457
46leukocyte tethering or rolling (GO:0050901)4.31945283
47renal filtration (GO:0097205)4.31405255
48negative regulation of keratinocyte proliferation (GO:0010839)4.30769855
49regulation of cGMP biosynthetic process (GO:0030826)4.30261233
50cellular response to fatty acid (GO:0071398)4.26589365
51hormone catabolic process (GO:0042447)4.26335531
52regulation of viral entry into host cell (GO:0046596)4.21426757
53urea cycle (GO:0000050)4.19948501
54purine deoxyribonucleotide catabolic process (GO:0009155)4.19664561
55antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.19118598
56tumor necrosis factor-mediated signaling pathway (GO:0033209)4.12678081
57lipoprotein transport (GO:0042953)4.10459849
58N-acetylglucosamine metabolic process (GO:0006044)4.09871519
59antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.06275921
60urea metabolic process (GO:0019627)4.04546958
61negative regulation of epidermal cell differentiation (GO:0045605)4.03626794
62regulation of systemic arterial blood pressure (GO:0003073)4.01926627
63receptor guanylyl cyclase signaling pathway (GO:0007168)4.00183135
64adhesion of symbiont to host cell (GO:0044650)3.99354086
65virion attachment to host cell (GO:0019062)3.99354086
66positive regulation of acute inflammatory response (GO:0002675)3.93496825
67regulation of dendritic cell antigen processing and presentation (GO:0002604)3.93015945
68antigen processing and presentation of endogenous antigen (GO:0019883)3.92616826
69peptide catabolic process (GO:0043171)3.89437499
70regulation of keratinocyte proliferation (GO:0010837)3.85953189
71positive regulation of glycoprotein biosynthetic process (GO:0010560)3.85646056
72very-low-density lipoprotein particle assembly (GO:0034379)3.83583231
73arginine metabolic process (GO:0006525)3.81987088
74nitrogen cycle metabolic process (GO:0071941)3.80432988
75positive regulation of cell fate commitment (GO:0010455)3.79986559
76positive regulation of glucose transport (GO:0010828)3.78203253
77intestinal cholesterol absorption (GO:0030299)3.73481239
78galactose catabolic process (GO:0019388)3.73361000
79regulation of hormone metabolic process (GO:0032350)3.70400141
80regulation of cytokine production involved in immune response (GO:0002718)3.67485603
81positive regulation of monocyte chemotaxis (GO:0090026)3.67076484
82negative regulation of protein tyrosine kinase activity (GO:0061099)3.61546144
83positive regulation of glycoprotein metabolic process (GO:1903020)3.60622147
84regulation of cGMP metabolic process (GO:0030823)3.59521055
85protein activation cascade (GO:0072376)3.58703673
86membrane tubulation (GO:0097320)3.51201309
87drug metabolic process (GO:0017144)3.50711937
88nucleotide transmembrane transport (GO:1901679)3.49780466
89ethanol oxidation (GO:0006069)3.46951664
90peptide hormone processing (GO:0016486)3.45430701
91regulation of podosome assembly (GO:0071801)3.43279835
92renal system process involved in regulation of blood volume (GO:0001977)3.42333598
93adhesion of symbiont to host (GO:0044406)3.41827306
94vitamin A metabolic process (GO:0006776)3.39308571
95regulation of vitamin metabolic process (GO:0030656)3.36696382
96positive regulation of Cdc42 GTPase activity (GO:0043089)3.36180400
97arginine catabolic process (GO:0006527)3.32599999
98regulation of triglyceride catabolic process (GO:0010896)3.32532494
99digestion (GO:0007586)3.29813839
100positive regulation of triglyceride lipase activity (GO:0061365)3.26795380
101positive regulation of lipoprotein lipase activity (GO:0051006)3.26795380
102positive regulation of cGMP biosynthetic process (GO:0030828)3.26213471
103columnar/cuboidal epithelial cell development (GO:0002066)3.25166752
104plasma lipoprotein particle assembly (GO:0034377)3.24657549
105GDP-mannose metabolic process (GO:0019673)3.23843657
106UDP-N-acetylglucosamine metabolic process (GO:0006047)3.20765207
107cardiac conduction (GO:0061337)3.20015904
108cGMP-mediated signaling (GO:0019934)3.17450818
109transcytosis (GO:0045056)3.17386421
110actin filament depolymerization (GO:0030042)3.16785239
111regulation of actin nucleation (GO:0051125)3.16666837
112glutathione derivative biosynthetic process (GO:1901687)3.09797911
113glutathione derivative metabolic process (GO:1901685)3.09797911
114glucuronate metabolic process (GO:0019585)3.08142053
115uronic acid metabolic process (GO:0006063)3.08142053
116cellular glucuronidation (GO:0052695)3.06091922
117vitamin transmembrane transport (GO:0035461)3.04822090
118diacylglycerol metabolic process (GO:0046339)3.04781997
119alkaloid metabolic process (GO:0009820)3.03751261
120protein-lipid complex assembly (GO:0065005)3.03400004
121glycolipid catabolic process (GO:0019377)3.03224402
122eosinophil chemotaxis (GO:0048245)3.02308092
123response to nitric oxide (GO:0071731)3.01347169
124glycosphingolipid catabolic process (GO:0046479)3.01117028
125positive regulation of chemokine production (GO:0032722)3.01070993
126humoral immune response (GO:0006959)2.99170146
127positive regulation of antigen processing and presentation (GO:0002579)2.98574363
128phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.97451209
129monocarboxylic acid transport (GO:0015718)2.97309911
130negative regulation of epidermis development (GO:0045683)2.97152367
131glucose 6-phosphate metabolic process (GO:0051156)2.96837815
132signal peptide processing (GO:0006465)2.96436484
133purine deoxyribonucleotide metabolic process (GO:0009151)2.95269406
134sexual reproduction (GO:0019953)2.93961185
135fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.90298370
136cysteine metabolic process (GO:0006534)2.90226458
137negative regulation of viral transcription (GO:0032897)2.89769573
138drug catabolic process (GO:0042737)2.89282826
139regulation of catecholamine secretion (GO:0050433)2.83356056
140oligosaccharide biosynthetic process (GO:0009312)2.83126640
141cyclooxygenase pathway (GO:0019371)2.83095174
142nucleoside diphosphate biosynthetic process (GO:0009133)2.82945554
143ventricular cardiac muscle cell action potential (GO:0086005)2.80932514
144positive regulation of cGMP metabolic process (GO:0030825)2.80539914
145angiotensin maturation (GO:0002003)2.80266239
146glutamine family amino acid biosynthetic process (GO:0009084)2.79544833
147regulation of respiratory burst (GO:0060263)2.79188094
148exogenous drug catabolic process (GO:0042738)2.73546233
149glucosamine-containing compound metabolic process (GO:1901071)2.73163101
150columnar/cuboidal epithelial cell differentiation (GO:0002065)2.73021607
151cellular response to nutrient (GO:0031670)2.72576521
152regulation of cholesterol esterification (GO:0010872)2.72103586
153regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.71733255
154desmosome organization (GO:0002934)2.71551951
155midgut development (GO:0007494)2.69933778
156regulation of water loss via skin (GO:0033561)2.69588687
157positive regulation of lipid catabolic process (GO:0050996)2.69578849
158base-excision repair, AP site formation (GO:0006285)2.69530909
159fructose metabolic process (GO:0006000)2.69438856
160keratinocyte development (GO:0003334)2.68415715
161eosinophil migration (GO:0072677)2.67860986
162receptor catabolic process (GO:0032801)2.67087710
163negative regulation of actin filament depolymerization (GO:0030835)2.65159977
164regulation of hydrogen peroxide metabolic process (GO:0010310)2.63432765
165actin filament capping (GO:0051693)2.63328421
166sulfur amino acid catabolic process (GO:0000098)2.62616520
167glutathione biosynthetic process (GO:0006750)2.60170977
168lipoprotein metabolic process (GO:0042157)2.59576515
169cytoskeletal anchoring at plasma membrane (GO:0007016)2.59173415
170regulation of glucose import (GO:0046324)2.58984770
171negative regulation of blood pressure (GO:0045776)2.56330874
172protein O-linked glycosylation (GO:0006493)2.55774917
173amino sugar metabolic process (GO:0006040)2.52194459
174regulation of cholesterol homeostasis (GO:2000188)2.51097802
175regulation of monocyte chemotaxis (GO:0090025)2.51022576
176regulation of cholesterol metabolic process (GO:0090181)2.50972094
177negative regulation by host of viral transcription (GO:0043922)2.47267214
178regulation of cellular amide metabolic process (GO:0034248)2.45788902
179positive regulation of production of molecular mediator of immune response (GO:0002702)2.43168922
180killing of cells of other organism (GO:0031640)2.42198299
181disruption of cells of other organism (GO:0044364)2.42198299
182bile acid and bile salt transport (GO:0015721)10.8508724
183intestinal epithelial cell development (GO:0060576)10.0074134

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human4.22743378
2CDX2_20551321_ChIP-Seq_CACO-2_Human4.13329334
3THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse3.85780743
4ESR1_20079471_ChIP-ChIP_T-47D_Human3.85308825
5ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.77133300
6TRIM28_21343339_ChIP-Seq_HEK293_Human3.57947158
7BP1_19119308_ChIP-ChIP_Hs578T_Human2.87521508
8CDX2_19796622_ChIP-Seq_MESCs_Mouse2.67417813
9PPARA_22158963_ChIP-Seq_LIVER_Mouse2.58425965
10SOX2_27498859_Chip-Seq_STOMACH_Mouse2.54144475
11ZNF263_19887448_ChIP-Seq_K562_Human2.52819811
12SOX2_20726797_ChIP-Seq_SW620_Human2.49680430
13IRF8_22096565_ChIP-ChIP_GC-B_Human2.40990917
14STAT1_20625510_ChIP-Seq_HELA_Human2.37087007
15ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse2.29549276
16PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.23158173
17RXR_22158963_ChIP-Seq_LIVER_Mouse2.22237811
18MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.16518685
19RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.07421651
20* GATA6_25053715_ChIP-Seq_YYC3_Human2.05548024
21BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human2.01635656
22ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.00924656
23* GATA4_25053715_ChIP-Seq_YYC3_Human1.98732595
24RARG_19884340_ChIP-ChIP_MEFs_Mouse1.95590773
25CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.95391187
26ESR2_21235772_ChIP-Seq_MCF-7_Human1.93176697
27EGR1_23403033_ChIP-Seq_LIVER_Mouse1.92626251
28RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.91488775
29LXR_22158963_ChIP-Seq_LIVER_Mouse1.89922987
30TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.89127285
31FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.82277824
32ERG_21242973_ChIP-ChIP_JURKAT_Human1.78093909
33TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.68661187
34FOXO3_23340844_ChIP-Seq_DLD1_Human1.66650874
35PPAR_26484153_Chip-Seq_NCI-H1993_Human1.56474944
36* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.56347512
37SRY_22984422_ChIP-ChIP_TESTIS_Rat1.54049956
38LXR_22292898_ChIP-Seq_THP-1_Human1.50364432
39KLF5_25053715_ChIP-Seq_YYC3_Human1.47773804
40HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.45949294
41RUNX1_27514584_Chip-Seq_MCF-7_Human1.43000683
42CLOCK_20551151_ChIP-Seq_293T_Human1.42617865
43GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.41011616
44BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.36367546
45UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.35477201
46GATA1_19941826_ChIP-Seq_K562_Human1.35451964
47RACK7_27058665_Chip-Seq_MCF-7_Human1.35298775
48GATA2_21666600_ChIP-Seq_HMVEC_Human1.34791142
49SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.30966630
50KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.30918594
51GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28403738
52PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.27379334
53ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.26918136
54GATA2_19941826_ChIP-Seq_K562_Human1.25661403
55SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.25153293
56IKZF1_21737484_ChIP-ChIP_HCT116_Human1.25146903
57SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.25086968
58GATA1_22025678_ChIP-Seq_K562_Human1.24466569
59CTCF_27219007_Chip-Seq_Bcells_Human1.24285415
60AR_21909140_ChIP-Seq_LNCAP_Human1.22665054
61NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.22271467
62ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.22235485
63KDM2B_26808549_Chip-Seq_SUP-B15_Human1.21599598
64BCAT_22108803_ChIP-Seq_LS180_Human1.21269865
65EGR1_19032775_ChIP-ChIP_M12_Human1.19367098
66FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.18702697
67IRF8_21731497_ChIP-ChIP_J774_Mouse1.18589861
68KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.17478835
69SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.17342342
70TP53_16413492_ChIP-PET_HCT116_Human1.17061674
71AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.16761756
72KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.15716325
73TET1_21451524_ChIP-Seq_MESCs_Mouse1.14881130
74POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.14575410
75VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.12824506
76IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.12697829
77SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.07716581
78ZNF217_24962896_ChIP-Seq_MCF-7_Human1.06760567
79DROSHA_22980978_ChIP-Seq_HELA_Human1.04880350
80ELK3_25401928_ChIP-Seq_HUVEC_Human1.04720095
81ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.03370172
82CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.03264208
83BCOR_27268052_Chip-Seq_Bcells_Human1.02261572
84TCF4_18268006_ChIP-ChIP_LS174T_Human1.01662814
85VDR_24763502_ChIP-Seq_THP-1_Human1.00706186
86CTNNB1_20460455_ChIP-Seq_HCT116_Human1.00468937
87* HNF4A_19822575_ChIP-Seq_HepG2_Human0.99965818
88KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.99608016
89ATF3_27146783_Chip-Seq_COLON_Human0.98732405
90TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.98650280
91JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.96912649
92NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.96323619
93SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.95803176
94SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.94519704
95NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.94014791
96GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.93432512
97MTF2_20144788_ChIP-Seq_MESCs_Mouse0.93012752
98CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.91656194
99SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90916628
100RXR_22108803_ChIP-Seq_LS180_Human0.90488518
101STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.90472302
102RAD21_21589869_ChIP-Seq_MESCs_Mouse0.89924989
103NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.89283687
104CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.87595577
105EZH2_27294783_Chip-Seq_ESCs_Mouse0.87566274
106P63_26484246_Chip-Seq_KERATINOCYTES_Human0.87561373
107* DNAJC2_21179169_ChIP-ChIP_NT2_Human0.87323206
108IRF8_27001747_Chip-Seq_BMDM_Mouse0.87034675
109SPI1_23127762_ChIP-Seq_K562_Human0.86898858
110NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.86264471
111* GATA3_24758297_ChIP-Seq_MCF-7_Human0.85970628
112CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.85624808
113P300_27058665_Chip-Seq_ZR-75-30cells_Human0.85527280
114ELF5_23300383_ChIP-Seq_T47D_Human0.85355464
115SA1_27219007_Chip-Seq_ERYTHROID_Human0.84932783
116CDX2_22108803_ChIP-Seq_LS180_Human0.84078659
117* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.82675040
118* FOXA1_25552417_ChIP-Seq_VCAP_Human0.82222828
119SMAD_19615063_ChIP-ChIP_OVARY_Human0.81282382
120SA1_27219007_Chip-Seq_Bcells_Human0.80827346
121VDR_21846776_ChIP-Seq_THP-1_Human0.80793361
122CREB1_26743006_Chip-Seq_LNCaP_Human0.80451185
123SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.80289470
124FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.80010539
125ESR1_21235772_ChIP-Seq_MCF-7_Human0.79589782
126TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.79442242
127STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.79185755
128GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.78926394
129E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.78280423
130NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.77923970
131CTCF_27219007_Chip-Seq_ERYTHROID_Human0.77823703
132* FOXA2_19822575_ChIP-Seq_HepG2_Human0.77609953
133ELF1_20517297_ChIP-Seq_JURKAT_Human0.76642027
134ZFP281_18757296_ChIP-ChIP_E14_Mouse0.76585842
135BCL6_27268052_Chip-Seq_Bcells_Human0.75090354

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003868_abnormal_feces_composition6.23752228
2MP0005360_urolithiasis5.13521063
3MP0001666_abnormal_nutrient_absorption4.23438091
4MP0005666_abnormal_adipose_tissue3.85862010
5MP0002139_abnormal_hepatobiliary_system3.53941318
6MP0001873_stomach_inflammation3.33294141
7MP0009379_abnormal_foot_pigmentation3.32909249
8MP0005085_abnormal_gallbladder_physiolo3.32558004
9MP0010155_abnormal_intestine_physiology3.31238170
10MP0009780_abnormal_chondrocyte_physiolo3.15190372
11MP0010234_abnormal_vibrissa_follicle3.09857183
12MP0003866_abnormal_defecation2.91169939
13MP0008875_abnormal_xenobiotic_pharmacok2.85270172
14MP0004858_abnormal_nervous_system2.78312220
15MP0002277_abnormal_respiratory_mucosa2.72857042
16MP0004264_abnormal_extraembryonic_tissu2.71906188
17MP0003252_abnormal_bile_duct2.63677942
18MP0000490_abnormal_crypts_of2.60527708
19MP0000465_gastrointestinal_hemorrhage2.58167162
20MP0005365_abnormal_bile_salt2.48601462
21MP0001663_abnormal_digestive_system2.46053966
22MP0003183_abnormal_peptide_metabolism2.40578146
23MP0000477_abnormal_intestine_morphology2.37298741
24MP0003011_delayed_dark_adaptation2.34528612
25MP0003705_abnormal_hypodermis_morpholog2.32799480
26MP0005375_adipose_tissue_phenotype2.25196791
27MP0001664_abnormal_digestion2.19969480
28MP0000462_abnormal_digestive_system2.11548151
29MP0005381_digestive/alimentary_phenotyp2.09783498
30MP0005409_darkened_coat_color2.06905075
31MP0004019_abnormal_vitamin_homeostasis2.04518098
32MP0005165_increased_susceptibility_to1.92521309
33MP0005451_abnormal_body_composition1.90966511
34MP0002876_abnormal_thyroid_physiology1.87881006
35MP0004782_abnormal_surfactant_physiolog1.86762899
36MP0003300_gastrointestinal_ulcer1.68859509
37MP0004185_abnormal_adipocyte_glucose1.66052484
38MP0005076_abnormal_cell_differentiation1.51367779
39MP0000678_abnormal_parathyroid_gland1.50749727
40MP0004147_increased_porphyrin_level1.50450275
41MP0001849_ear_inflammation1.50333986
42MP0000537_abnormal_urethra_morphology1.49986813
43MP0003191_abnormal_cellular_cholesterol1.45981203
44MP0005448_abnormal_energy_balance1.42834704
45MP0003329_amyloid_beta_deposits1.42501289
46MP0001764_abnormal_homeostasis1.42089366
47MP0010329_abnormal_lipoprotein_level1.39297561
48MP0005377_hearing/vestibular/ear_phenot1.32914329
49MP0003878_abnormal_ear_physiology1.32914329
50MP0005503_abnormal_tendon_morphology1.29937435
51MP0002166_altered_tumor_susceptibility1.29478552
52MP0010352_gastrointestinal_tract_polyps1.28501201
53MP0005334_abnormal_fat_pad1.27349095
54MP0003879_abnormal_hair_cell1.22496854
55MP0009840_abnormal_foam_cell1.22319860
56MP0005387_immune_system_phenotype1.20674792
57MP0001790_abnormal_immune_system1.20674792
58MP0000604_amyloidosis1.20157826
59MP0009785_altered_susceptibility_to1.17206922
60MP0002136_abnormal_kidney_physiology1.15845658
61MP0002118_abnormal_lipid_homeostasis1.14118957
62MP0001835_abnormal_antigen_presentation1.12457881
63MP0010030_abnormal_orbit_morphology1.09760802
64MP0002971_abnormal_brown_adipose1.08937625
65MP0005025_abnormal_response_to1.07760343
66MP0001756_abnormal_urination1.07736614
67MP0006054_spinal_hemorrhage1.03989976
68MP0001958_emphysema1.01992906
69MP0005670_abnormal_white_adipose1.01750674
70MP0001501_abnormal_sleep_pattern0.98529526
71MP0002822_catalepsy0.97688998
72MP0010678_abnormal_skin_adnexa0.97321378
73MP0003724_increased_susceptibility_to0.94124786
74MP0008438_abnormal_cutaneous_collagen0.93462424
75MP0001188_hyperpigmentation0.92411306
76MP0005584_abnormal_enzyme/coenzyme_acti0.90629428
77MP0005636_abnormal_mineral_homeostasis0.90396625
78MP0004859_abnormal_synaptic_plasticity0.86993465
79MP0000249_abnormal_blood_vessel0.86641720
80MP0005166_decreased_susceptibility_to0.84665647
81MP0002796_impaired_skin_barrier0.84308548
82MP0005058_abnormal_lysosome_morphology0.82719728
83MP0002933_joint_inflammation0.82602228
84MP0001845_abnormal_inflammatory_respons0.81703574
85MP0005535_abnormal_body_temperature0.80507086
86MP0002896_abnormal_bone_mineralization0.80095608
87MP0000230_abnormal_systemic_arterial0.79089975
88MP0000685_abnormal_immune_system0.78929891
89MP0000470_abnormal_stomach_morphology0.78894252
90MP0005319_abnormal_enzyme/_coenzyme0.77100091
91MP0005023_abnormal_wound_healing0.76834767
92MP0008469_abnormal_protein_level0.75709069
93MP0002006_tumorigenesis0.75201728
94MP0003075_altered_response_to0.75157893
95MP0004043_abnormal_pH_regulation0.75145844
96MP0002998_abnormal_bone_remodeling0.73629134
97MP0008775_abnormal_heart_ventricle0.72950360
98MP0000013_abnormal_adipose_tissue0.72931346
99MP0009764_decreased_sensitivity_to0.72289870
100MP0003091_abnormal_cell_migration0.71736428
101MP0003448_altered_tumor_morphology0.71694633
102MP0002098_abnormal_vibrissa_morphology0.70026954
103MP0003806_abnormal_nucleotide_metabolis0.69813660
104MP0010307_abnormal_tumor_latency0.69749065
105MP0001440_abnormal_grooming_behavior0.68209146
106MP0000609_abnormal_liver_physiology0.67949750
107MP0004885_abnormal_endolymph0.67804804
108MP0004947_skin_inflammation0.67397349
109MP0001881_abnormal_mammary_gland0.66487053
110MP0002148_abnormal_hypersensitivity_rea0.64883518
111MP0009053_abnormal_anal_canal0.64060334
112MP0004270_analgesia0.64024346
113MP0003303_peritoneal_inflammation0.63773216
114MP0009115_abnormal_fat_cell0.62539156
115MP0000538_abnormal_urinary_bladder0.60156983
116MP0002138_abnormal_hepatobiliary_system0.59696167
117MP0005167_abnormal_blood-brain_barrier0.59562275
118MP0008004_abnormal_stomach_pH0.58502243
119MP0002089_abnormal_postnatal_growth/wei0.58084114
120MP0008872_abnormal_physiological_respon0.57976660
121MP0009643_abnormal_urine_homeostasis0.57500188
122MP0005248_abnormal_Harderian_gland0.55082074
123MP0005332_abnormal_amino_acid0.53287123
124MP0003828_pulmonary_edema0.53263605
125MP0005084_abnormal_gallbladder_morpholo0.52495257
126MP0003436_decreased_susceptibility_to0.52261840
127MP0005671_abnormal_response_to0.51523156
128MP0003566_abnormal_cell_adhesion0.51433193
129MP0001765_abnormal_ion_homeostasis0.50404337
130MP0001216_abnormal_epidermal_layer0.50290200
131MP0001533_abnormal_skeleton_physiology0.49843891
132MP0003453_abnormal_keratinocyte_physiol0.49210299
133MP0000467_abnormal_esophagus_morphology0.48546584
134MP0000383_abnormal_hair_follicle0.48323793
135MP0008873_increased_physiological_sensi0.45776304
136MP0001879_abnormal_lymphatic_vessel0.45700991
137MP0009931_abnormal_skin_appearance0.45090001
138MP0005275_abnormal_skin_tensile0.43137816
139MP0006082_CNS_inflammation0.42242801
140MP0000003_abnormal_adipose_tissue0.41324037

Predicted human phenotypes

RankGene SetZ-score
1Systemic lupus erythematosus (HP:0002725)7.67942615
2Micronodular cirrhosis (HP:0001413)6.78497787
3Right ventricular cardiomyopathy (HP:0011663)5.86062004
4Complement deficiency (HP:0004431)5.38563249
5Abnormality of complement system (HP:0005339)5.12049360
6Ileus (HP:0002595)4.90411281
7Bundle branch block (HP:0011710)4.79715499
8Glomerulonephritis (HP:0000099)4.77087826
9Abdominal distention (HP:0003270)4.50437895
10Esophageal varix (HP:0002040)4.42867401
11Abnormality of the vitamin B12 metabolism (HP:0004341)4.33968799
12Abnormality of vitamin B metabolism (HP:0004340)4.09140008
13Syncope (HP:0001279)4.05349432
14Abnormality of vitamin metabolism (HP:0100508)3.74520987
15Abnormality of glutamine family amino acid metabolism (HP:0010902)3.73102655
16Nephritis (HP:0000123)3.72834560
17Woolly hair (HP:0002224)3.62822733
18Malnutrition (HP:0004395)3.51825189
19Hyperparathyroidism (HP:0000843)3.33471988
20Intrahepatic cholestasis (HP:0001406)3.32429548
21Prolonged QT interval (HP:0001657)3.32228727
22Hemorrhage of the eye (HP:0011885)3.25063935
23Pigmentary retinal degeneration (HP:0001146)3.22677199
24Abnormality of monocarboxylic acid metabolism (HP:0010996)3.22520939
25Fat malabsorption (HP:0002630)3.19742906
26Glycosuria (HP:0003076)3.17713906
27Abnormality of urine glucose concentration (HP:0011016)3.17713906
28Eczematoid dermatitis (HP:0000976)3.17634907
29Decreased circulating renin level (HP:0003351)3.15508873
30Hypoplastic ischia (HP:0003175)3.10782361
31Xanthomatosis (HP:0000991)3.07813413
32Exocrine pancreatic insufficiency (HP:0001738)3.02878876
33Abnormal foot bone ossification (HP:0010675)3.01900919
34Abnormality of sulfur amino acid metabolism (HP:0004339)3.00341228
35Oligomenorrhea (HP:0000876)2.99234681
36Alkalosis (HP:0001948)2.83735391
37Generalized aminoaciduria (HP:0002909)2.81635382
38Metabolic alkalosis (HP:0200114)2.77683861
39Wide cranial sutures (HP:0010537)2.71365604
40Abnormality of the ischium (HP:0003174)2.67466975
41Hypercortisolism (HP:0001578)2.67453585
42Chronic diarrhea (HP:0002028)2.62478176
43Hyperactive renin-angiotensin system (HP:0000841)2.62165765
44Hyperlipoproteinemia (HP:0010980)2.61664986
45Hypobetalipoproteinemia (HP:0003563)2.61164430
46Confusion (HP:0001289)2.58824515
47Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.58584692
48Atrophic scars (HP:0001075)2.58131020
49Abnormality of the gastric mucosa (HP:0004295)2.58073346
50Abnormality of purine metabolism (HP:0004352)2.55605039
51Dysmetric saccades (HP:0000641)2.50495057
52Facial shape deformation (HP:0011334)2.48844118
53Potter facies (HP:0002009)2.48844118
54Palpitations (HP:0001962)2.48176228
55Villous atrophy (HP:0011473)2.47935339
56Abnormality of small intestinal villus morphology (HP:0011472)2.47935339
57Hyperglycinuria (HP:0003108)2.46860885
58Protuberant abdomen (HP:0001538)2.46694384
59Abnormality of proline metabolism (HP:0010907)2.44549132
60Hydroxyprolinuria (HP:0003080)2.44549132
61Nephrolithiasis (HP:0000787)2.44353289
62Abnormal atrioventricular conduction (HP:0005150)2.43369962
63Heart block (HP:0012722)2.41440105
64Abnormality of aspartate family amino acid metabolism (HP:0010899)2.39644397
65Hyperammonemia (HP:0001987)2.37734433
66Hypercholesterolemia (HP:0003124)2.37278118
67Increased purine levels (HP:0004368)2.36978281
68Hyperuricemia (HP:0002149)2.36978281
69Conjugated hyperbilirubinemia (HP:0002908)2.36653000
70Multiple lipomas (HP:0001012)2.36132299
71Abnormality of renin-angiotensin system (HP:0000847)2.35811935
72Posterior subcapsular cataract (HP:0007787)2.34389966
73Nausea (HP:0002018)2.33309631
74Rectal prolapse (HP:0002035)2.32150789
75Hypophosphatemia (HP:0002148)2.31992180
76Emphysema (HP:0002097)2.31292116
77Congenital, generalized hypertrichosis (HP:0004540)2.29127318
78Ventricular tachycardia (HP:0004756)2.27949934
79Proximal tubulopathy (HP:0000114)2.27501880
80Cerebral palsy (HP:0100021)2.26509999
81Abnormality of glycine metabolism (HP:0010895)2.25028067
82Abnormality of serine family amino acid metabolism (HP:0010894)2.25028067
83Growth hormone excess (HP:0000845)2.23408140
84Segmental peripheral demyelination/remyelination (HP:0003481)2.22037250
85Abnormal vertebral ossification (HP:0100569)2.20511719
86Pancreatitis (HP:0001733)2.19916263
87Late onset (HP:0003584)2.19156729
88Gingivitis (HP:0000230)2.17433781
89Increased serum pyruvate (HP:0003542)2.16106136
90Abnormality of glycolysis (HP:0004366)2.16106136
91Hypolipoproteinemia (HP:0010981)2.14771153
92Abnormal pancreas size (HP:0012094)2.14739470
93Hypotension (HP:0002615)2.14444338
94Abnormality of the nasal mucosa (HP:0000433)2.11131795
95Hyperphosphaturia (HP:0003109)2.08030583
96Gastrointestinal dysmotility (HP:0002579)2.07548181
97Orchitis (HP:0100796)2.07308877
98Interstitial pulmonary disease (HP:0006530)2.05237887
99Gastrointestinal stroma tumor (HP:0100723)2.03164256
100Onycholysis (HP:0001806)2.03065658
101Abnormality of pyrimidine metabolism (HP:0004353)2.02345827
102Focal segmental glomerulosclerosis (HP:0000097)2.01472494
103Subcapsular cataract (HP:0000523)2.00425415
104Aplasia/Hypoplasia of the clavicles (HP:0006710)1.98283353
105Colitis (HP:0002583)1.97060968
106Ventricular fibrillation (HP:0001663)1.97003280
107Milia (HP:0001056)1.93848738
108Dicarboxylic aciduria (HP:0003215)1.92810280
109Abnormality of dicarboxylic acid metabolism (HP:0010995)1.92810280
110Bradycardia (HP:0001662)1.91088523
111Deep venous thrombosis (HP:0002625)1.89504884
112Renal Fanconi syndrome (HP:0001994)1.89092991
113Hyperphosphatemia (HP:0002905)1.88635464
114Thin bony cortex (HP:0002753)1.88010917
115Flat acetabular roof (HP:0003180)1.86033335
116Acanthocytosis (HP:0001927)1.85127289
117Congenital sensorineural hearing impairment (HP:0008527)1.84640580
118Action tremor (HP:0002345)1.84442923
119Short clavicles (HP:0000894)1.83985751
120Subacute progressive viral hepatitis (HP:0006572)1.83351486
121Amyloidosis (HP:0011034)1.83106754
122Abnormality of abdominal situs (HP:0011620)1.82758112
123Abdominal situs inversus (HP:0003363)1.82758112
124Abnormal EKG (HP:0003115)1.81924311
125Cholecystitis (HP:0001082)1.81563661
126Abnormal gallbladder physiology (HP:0012438)1.81563661
127Steatorrhea (HP:0002570)1.79396345
128Abnormal tarsal ossification (HP:0008369)1.78590599
129Recurrent bronchitis (HP:0002837)1.78248162
130Abnormal glucose tolerance (HP:0001952)1.77860654
131Hypoglycemic coma (HP:0001325)1.77745034
132Myokymia (HP:0002411)1.77297278
133Fragile nails (HP:0001808)1.76979246
134Increased muscle lipid content (HP:0009058)1.76433596
135Delayed epiphyseal ossification (HP:0002663)1.75345097
136Rhabdomyolysis (HP:0003201)1.75049647
137Hypoalphalipoproteinemia (HP:0003233)1.74403846
138Peritonitis (HP:0002586)1.74036673
139Vasculitis (HP:0002633)1.73313965
140Abnormality of nucleobase metabolism (HP:0010932)1.73031806
141Failure to thrive in infancy (HP:0001531)1.72642383
142Increased intramyocellular lipid droplets (HP:0012240)1.72030739
143Insulin resistance (HP:0000855)1.71386631
144Epidermoid cyst (HP:0200040)1.71074464
145Bone cyst (HP:0012062)1.70602712
146Widely patent fontanelles and sutures (HP:0004492)1.69853140
147Toxemia of pregnancy (HP:0100603)1.69712951
148Epileptic encephalopathy (HP:0200134)1.69674145
149Germ cell neoplasia (HP:0100728)1.68968447
150Ventricular arrhythmia (HP:0004308)1.68964975
151Premature loss of primary teeth (HP:0006323)1.67368921
152Megaloblastic anemia (HP:0001889)1.66415319
153Skin rash (HP:0000988)1.66204883
154Bone pain (HP:0002653)1.66080213
155Metabolic acidosis (HP:0001942)1.65194571
156Skin nodule (HP:0200036)1.64395289
157Purpura (HP:0000979)1.63133171
158Pili torti (HP:0003777)1.61982165
159Spontaneous hematomas (HP:0007420)1.61077756
160Renal tubular acidosis (HP:0001947)1.60203171
161Glomerulosclerosis (HP:0000096)1.59605128

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK6.63779601
2NME16.34808911
3RPS6KB25.03062354
4ACVR1B4.78737935
5STK243.28288401
6FGFR43.05545655
7TEC2.98561227
8EPHA32.71025804
9MST42.69292655
10ERN12.58056449
11EEF2K2.43518799
12LMTK22.39671763
13TYK22.29099823
14PTK62.28941527
15EPHA22.15759124
16EPHB12.14684649
17BLK2.12010075
18TAOK12.04201134
19LATS12.03824468
20MAP2K21.97177091
21EPHB21.90501477
22TAOK31.80626340
23MST1R1.68373596
24TRIB31.62799360
25PIK3CA1.62569065
26CDC42BPA1.55833394
27TGFBR21.50118375
28FGFR31.47039101
29CAMK2D1.43396888
30PRPF4B1.41286225
31MAP3K111.40283846
32PRKG21.39003670
33CAMK2B1.37507422
34TESK21.31438339
35GRK11.27481051
36TESK11.26034221
37NLK1.18949974
38MAP3K21.18496127
39MAP3K71.16313681
40MAP2K11.14310083
41GRK61.08072038
42OXSR11.04606007
43JAK11.03455695
44KSR21.03289158
45PDK21.00989926
46CSK0.99208376
47CAMK2G0.98887868
48PDGFRA0.98149066
49ZAP700.97856956
50PKN20.97450485
51DMPK0.96742057
52MATK0.95286336
53FER0.94716154
54MAP3K60.92574238
55MAP3K100.91254370
56PAK40.90183935
57ILK0.86370066
58CAMK10.81320482
59PDPK10.79612990
60IKBKE0.77779404
61IRAK10.77729731
62MAP3K10.76228246
63KIT0.75300519
64MAP3K120.74195542
65PTK20.73839088
66JAK30.73802435
67NUAK10.73771139
68LRRK20.73277849
69AKT30.70688097
70TRPM70.68764281
71JAK20.67792496
72CDK120.67583106
73MAP3K80.63690073
74CSNK1G30.62362969
75PRKACG0.61748520
76ITK0.59223950
77ABL20.57776447
78RET0.57208475
79PAK30.55907816
80MYLK0.55670947
81CSNK1A1L0.54930433
82TNIK0.52276026
83MAP3K30.51445759
84MAPK110.50696782
85MAPKAPK30.50005837
86LIMK10.49592267
87SMG10.49109402
88CSNK1G20.48508822
89BMX0.48469227
90STK100.47100675
91MAPKAPK20.46889875
92RIPK10.46879544
93ERBB20.46856052
94PRKCE0.46324893
95PDK10.44453210
96CDK190.43914610
97PRKCQ0.42712788
98CSNK1A10.41844724
99RIPK40.40929296
100MAP3K140.40397029
101PRKCZ0.39827703
102CSF1R0.39800174
103EPHA40.38013513
104FYN0.36825058
105MAPK70.36696829
106CLK10.36620293
107KDR0.36539672
108DYRK1B0.35980589
109SRC0.35093196
110HIPK20.34309160
111ALK0.33909928
112MAPKAPK50.31959936
113CAMK2A0.31533120
114TBK10.31523181
115PRKAA20.30873439
116YES10.30274152
117SYK0.30140323
118IGF1R0.30007511
119CSNK1G10.29990115
120MET0.29980785
121MAP4K10.29736692
122PRKCA0.29475165
123PDGFRB0.28882037
124ERBB40.28184494
125PRKCD0.28040117
126BCR0.27345323
127LYN0.27261555
128RPS6KC10.26725647
129RPS6KL10.26725647
130CDK60.26536311
131PAK10.26222167
132BTK0.25730051
133LCK0.25172264
134TAOK20.24404075
135PAK60.24278954
136PDK30.23215119
137PDK40.23215119
138CAMKK10.22319588
139MAP2K60.22260741
140HCK0.21119433
141DDR20.19751754
142ICK0.18508750
143PIM20.17868906
144RPS6KA20.17690176
145STK390.15894571
146PRKCI0.15837842
147PAK20.13652468
148AKT20.13252813

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005335.73352813
2Sulfur metabolism_Homo sapiens_hsa009204.13522682
3Butirosin and neomycin biosynthesis_Homo sapiens_hsa005243.24771870
4* Fat digestion and absorption_Homo sapiens_hsa049753.07216745
5Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005123.01940240
6PPAR signaling pathway_Homo sapiens_hsa033202.94273806
7Bile secretion_Homo sapiens_hsa049762.62376637
8Staphylococcus aureus infection_Homo sapiens_hsa051502.23851083
9Asthma_Homo sapiens_hsa053102.18922317
10Galactose metabolism_Homo sapiens_hsa000522.06006152
11Maturity onset diabetes of the young_Homo sapiens_hsa049502.00409408
12Vibrio cholerae infection_Homo sapiens_hsa051101.83478380
13Nitrogen metabolism_Homo sapiens_hsa009101.80378859
14Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.78771721
15Mineral absorption_Homo sapiens_hsa049781.78255330
16Intestinal immune network for IgA production_Homo sapiens_hsa046721.74563542
17Retinol metabolism_Homo sapiens_hsa008301.73870548
18Renin-angiotensin system_Homo sapiens_hsa046141.63868683
19Pentose phosphate pathway_Homo sapiens_hsa000301.60762773
20Allograft rejection_Homo sapiens_hsa053301.60754471
21Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.59376935
22Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.55454170
23Fructose and mannose metabolism_Homo sapiens_hsa000511.54316478
24Autoimmune thyroid disease_Homo sapiens_hsa053201.51956864
25Graft-versus-host disease_Homo sapiens_hsa053321.45666360
26Glutathione metabolism_Homo sapiens_hsa004801.42655655
27Cyanoamino acid metabolism_Homo sapiens_hsa004601.40391205
28Starch and sucrose metabolism_Homo sapiens_hsa005001.38292512
29Leukocyte transendothelial migration_Homo sapiens_hsa046701.33462849
30Complement and coagulation cascades_Homo sapiens_hsa046101.31758251
31Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.29736564
32Drug metabolism - other enzymes_Homo sapiens_hsa009831.25653091
33Selenocompound metabolism_Homo sapiens_hsa004501.25393690
34Phenylalanine metabolism_Homo sapiens_hsa003601.24443391
35Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.23038794
36Carbohydrate digestion and absorption_Homo sapiens_hsa049731.17884096
37Type I diabetes mellitus_Homo sapiens_hsa049401.16353772
38Tight junction_Homo sapiens_hsa045301.13846507
39Histidine metabolism_Homo sapiens_hsa003401.09416573
40Pyruvate metabolism_Homo sapiens_hsa006201.03556009
41Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.02331260
42Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.01034128
43Thyroid cancer_Homo sapiens_hsa052160.97376256
44Hepatitis C_Homo sapiens_hsa051600.96234459
45* Linoleic acid metabolism_Homo sapiens_hsa005910.95111916
46Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.93603198
47Antigen processing and presentation_Homo sapiens_hsa046120.93152466
48Leishmaniasis_Homo sapiens_hsa051400.92837378
49Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.91177766
50Protein digestion and absorption_Homo sapiens_hsa049740.90804161
51Arginine biosynthesis_Homo sapiens_hsa002200.85587033
52Other glycan degradation_Homo sapiens_hsa005110.85569725
53Chemical carcinogenesis_Homo sapiens_hsa052040.84213771
54Pentose and glucuronate interconversions_Homo sapiens_hsa000400.81482524
55Amoebiasis_Homo sapiens_hsa051460.81380905
56Gastric acid secretion_Homo sapiens_hsa049710.79865281
57Vitamin digestion and absorption_Homo sapiens_hsa049770.78759316
58Folate biosynthesis_Homo sapiens_hsa007900.78625688
59Glycerolipid metabolism_Homo sapiens_hsa005610.77903719
60Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.77436751
61Viral myocarditis_Homo sapiens_hsa054160.75892599
62Fatty acid degradation_Homo sapiens_hsa000710.74836841
63* alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.72337500
64Carbon metabolism_Homo sapiens_hsa012000.71621117
65Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.69325603
66* Pancreatic secretion_Homo sapiens_hsa049720.68724958
67Tyrosine metabolism_Homo sapiens_hsa003500.68704805
68Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.68345952
69Renin secretion_Homo sapiens_hsa049240.67874417
70Tryptophan metabolism_Homo sapiens_hsa003800.67273032
71Insulin secretion_Homo sapiens_hsa049110.66135403
72Alzheimers disease_Homo sapiens_hsa050100.63464723
73Caffeine metabolism_Homo sapiens_hsa002320.63249507
74ABC transporters_Homo sapiens_hsa020100.62171832
75Oxidative phosphorylation_Homo sapiens_hsa001900.59591013
76Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.59253964
77Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.58633350
78Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.58612075
79Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.56137498
80Toxoplasmosis_Homo sapiens_hsa051450.54248735
81Thyroid hormone synthesis_Homo sapiens_hsa049180.53620408
82Prion diseases_Homo sapiens_hsa050200.53452534
83Parkinsons disease_Homo sapiens_hsa050120.53235716
84Fatty acid metabolism_Homo sapiens_hsa012120.52949382
85Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.52478210
86Cardiac muscle contraction_Homo sapiens_hsa042600.51069496
87Peroxisome_Homo sapiens_hsa041460.49465076
88Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.47884282
89Butanoate metabolism_Homo sapiens_hsa006500.47185260
90Salivary secretion_Homo sapiens_hsa049700.44915346
91Bladder cancer_Homo sapiens_hsa052190.44029594
92Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.43181970
93Protein export_Homo sapiens_hsa030600.42245391
942-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.41919292
95Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.41914737
96GnRH signaling pathway_Homo sapiens_hsa049120.41871632
97Salmonella infection_Homo sapiens_hsa051320.41434745
98Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.40762325
99Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.40634887
100Dorso-ventral axis formation_Homo sapiens_hsa043200.40621462
101Biosynthesis of amino acids_Homo sapiens_hsa012300.39686391
102Primary bile acid biosynthesis_Homo sapiens_hsa001200.39608632
103Type II diabetes mellitus_Homo sapiens_hsa049300.39335746
104Sphingolipid metabolism_Homo sapiens_hsa006000.38586710
105Gap junction_Homo sapiens_hsa045400.38276614
106Steroid hormone biosynthesis_Homo sapiens_hsa001400.37737724
107Insulin resistance_Homo sapiens_hsa049310.37105183
108Adipocytokine signaling pathway_Homo sapiens_hsa049200.37030929
109Sulfur relay system_Homo sapiens_hsa041220.35218860
110Fatty acid biosynthesis_Homo sapiens_hsa000610.34581513
111Aldosterone synthesis and secretion_Homo sapiens_hsa049250.33753332
112Tuberculosis_Homo sapiens_hsa051520.33717945
113* Ether lipid metabolism_Homo sapiens_hsa005650.31340532
114Hematopoietic cell lineage_Homo sapiens_hsa046400.31169846
115Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.31168743
116* Glycerophospholipid metabolism_Homo sapiens_hsa005640.29774168
117Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.29482010
118Rheumatoid arthritis_Homo sapiens_hsa053230.28779480
119Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.27683745
120Chemokine signaling pathway_Homo sapiens_hsa040620.27666368
121Arginine and proline metabolism_Homo sapiens_hsa003300.27576041
122* Arachidonic acid metabolism_Homo sapiens_hsa005900.27387414
123Taste transduction_Homo sapiens_hsa047420.27036315
124B cell receptor signaling pathway_Homo sapiens_hsa046620.26956686
125Influenza A_Homo sapiens_hsa051640.26532090
126Central carbon metabolism in cancer_Homo sapiens_hsa052300.26410916
127VEGF signaling pathway_Homo sapiens_hsa043700.24931218
128Small cell lung cancer_Homo sapiens_hsa052220.24798841
129Estrogen signaling pathway_Homo sapiens_hsa049150.23709786
130Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.23142733
131Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.22521334
132Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.22130054
133Long-term depression_Homo sapiens_hsa047300.21503844
134Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.20461494
135HIF-1 signaling pathway_Homo sapiens_hsa040660.18805048
136African trypanosomiasis_Homo sapiens_hsa051430.18692903
137Pertussis_Homo sapiens_hsa051330.18561160
138Cholinergic synapse_Homo sapiens_hsa047250.18155683
139Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.18011262
140Phagosome_Homo sapiens_hsa041450.16294402
141TNF signaling pathway_Homo sapiens_hsa046680.14301463
142Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.14030507
143Fatty acid elongation_Homo sapiens_hsa000620.13749115

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