PLA2G2C

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cell-cell recognition (GO:0009988)9.72409705
2cilium or flagellum-dependent cell motility (GO:0001539)9.65954603
3multicellular organism reproduction (GO:0032504)9.60981123
4axonemal dynein complex assembly (GO:0070286)9.33991147
5piRNA metabolic process (GO:0034587)9.33825228
6spermatid development (GO:0007286)9.32813145
7epithelial cilium movement (GO:0003351)8.90465491
8plasma membrane fusion (GO:0045026)8.84248191
9motile cilium assembly (GO:0044458)8.68974252
10male meiosis (GO:0007140)8.46845263
11synaptonemal complex organization (GO:0070193)8.38603682
12synaptonemal complex assembly (GO:0007130)8.22664987
13reproduction (GO:0000003)8.22623482
14regulation of cilium movement (GO:0003352)8.12618642
15cilium movement (GO:0003341)7.51289547
16epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.23352710
17single fertilization (GO:0007338)6.61095065
18negative regulation of inclusion body assembly (GO:0090084)6.53459899
19spermatogenesis (GO:0007283)6.52862771
20sperm capacitation (GO:0048240)6.52393809
21male gamete generation (GO:0048232)6.50640517
22DNA methylation involved in gamete generation (GO:0043046)6.47044370
23organic cation transport (GO:0015695)6.02821759
24gamete generation (GO:0007276)5.99207778
25fertilization (GO:0009566)5.91672214
26male meiosis I (GO:0007141)5.76609338
27chromosome organization involved in meiosis (GO:0070192)5.75056626
28behavioral response to nicotine (GO:0035095)5.65390924
29microtubule depolymerization (GO:0007019)5.64741811
30germ cell development (GO:0007281)5.55557287
31regulation of inclusion body assembly (GO:0090083)5.39708177
32cellular process involved in reproduction in multicellular organism (GO:0022412)5.36002071
33meiotic nuclear division (GO:0007126)5.28585807
34calcium ion-dependent exocytosis (GO:0017156)5.03941915
35regulation of microtubule-based movement (GO:0060632)5.03078269
36DNA deamination (GO:0045006)4.73454062
37ventricular system development (GO:0021591)4.72287424
38multicellular organismal reproductive process (GO:0048609)4.70097671
39microtubule severing (GO:0051013)4.68047796
40L-fucose catabolic process (GO:0042355)4.62364035
41fucose catabolic process (GO:0019317)4.62364035
42L-fucose metabolic process (GO:0042354)4.62364035
43meiosis I (GO:0007127)4.62177696
44cell recognition (GO:0008037)4.61219389
45chromosome condensation (GO:0030261)4.59951907
46seminiferous tubule development (GO:0072520)4.52198567
47DNA packaging (GO:0006323)4.50668810
48glycerol ether metabolic process (GO:0006662)4.43039588
49spermatid nucleus differentiation (GO:0007289)4.34714031
50single strand break repair (GO:0000012)4.20803304
51ether metabolic process (GO:0018904)4.08591265
52response to pheromone (GO:0019236)3.99230616
53left/right pattern formation (GO:0060972)3.97395876
54meiotic cell cycle (GO:0051321)3.94374567
55protein polyglutamylation (GO:0018095)3.80734392
56multicellular organismal development (GO:0007275)3.76408217
57tryptophan catabolic process (GO:0006569)3.75822245
58indole-containing compound catabolic process (GO:0042436)3.75822245
59indolalkylamine catabolic process (GO:0046218)3.75822245
60negative regulation of telomere maintenance (GO:0032205)3.74778226
61indolalkylamine metabolic process (GO:0006586)3.72279387
62kynurenine metabolic process (GO:0070189)3.67254405
63chaperone-mediated protein complex assembly (GO:0051131)3.66524698
64synapsis (GO:0007129)3.66058840
65genitalia morphogenesis (GO:0035112)3.64997849
66protein localization to cilium (GO:0061512)3.58123295
67protein-cofactor linkage (GO:0018065)3.53395559
68regulation of spindle checkpoint (GO:0090231)3.51795470
69gene silencing by RNA (GO:0031047)3.48454522
70cellular ketone body metabolic process (GO:0046950)3.48055522
71meiotic cell cycle process (GO:1903046)3.46119052
72lactate metabolic process (GO:0006089)3.45837996
73detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.42857129
74intraciliary transport (GO:0042073)3.39404241
75platelet dense granule organization (GO:0060155)3.38951072
76sexual reproduction (GO:0019953)3.38371739
77kidney morphogenesis (GO:0060993)3.38291195
78mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.30816708
79mitochondrial respiratory chain complex I assembly (GO:0032981)3.30816708
80NADH dehydrogenase complex assembly (GO:0010257)3.30816708
81detection of light stimulus involved in sensory perception (GO:0050962)3.28697290
82detection of light stimulus involved in visual perception (GO:0050908)3.28697290
83preassembly of GPI anchor in ER membrane (GO:0016254)3.24939630
84tryptophan metabolic process (GO:0006568)3.24221029
85protein K11-linked deubiquitination (GO:0035871)3.22514015
86protein refolding (GO:0042026)3.21434515
87axoneme assembly (GO:0035082)3.19871391
88protein complex biogenesis (GO:0070271)3.19719615
89sequestering of actin monomers (GO:0042989)3.17353304
90regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.13513249
91water-soluble vitamin biosynthetic process (GO:0042364)3.12281283
92regulation of hexokinase activity (GO:1903299)3.10929790
93regulation of glucokinase activity (GO:0033131)3.10929790
94monoubiquitinated protein deubiquitination (GO:0035520)3.10022060
95glycolytic process (GO:0006096)3.09004947
96ketone body metabolic process (GO:1902224)3.08054730
97neural tube formation (GO:0001841)3.04658922
98carnitine transport (GO:0015879)3.02825197
99amino-acid betaine transport (GO:0015838)3.02825197
100mitochondrial respiratory chain complex assembly (GO:0033108)2.96731083
101negative regulation of mast cell activation (GO:0033004)2.96574480
102nucleus organization (GO:0006997)2.95476890
103cytidine metabolic process (GO:0046087)2.94990759
104cytidine catabolic process (GO:0006216)2.94990759
105cytidine deamination (GO:0009972)2.94990759
106nonmotile primary cilium assembly (GO:0035058)2.94136461
107cilium organization (GO:0044782)2.93081123
108somite rostral/caudal axis specification (GO:0032525)2.92652997
109ubiquinone biosynthetic process (GO:0006744)2.92198169
110carnitine transmembrane transport (GO:1902603)2.89736772
111gene silencing (GO:0016458)2.87869060
112microtubule-based movement (GO:0007018)2.87765879
113photoreceptor cell maintenance (GO:0045494)2.86545300
114indole-containing compound metabolic process (GO:0042430)2.85720603
115cellular biogenic amine catabolic process (GO:0042402)2.83734030
116amine catabolic process (GO:0009310)2.83734030
117RNA localization (GO:0006403)2.83124944
118positive regulation of macrophage activation (GO:0043032)2.82530325
119respiratory chain complex IV assembly (GO:0008535)2.81190649
120cilium assembly (GO:0042384)2.79654166
121synaptic transmission, cholinergic (GO:0007271)2.79406238
122mannosylation (GO:0097502)2.79331873
123regulation of meiosis I (GO:0060631)2.78871305
124tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.77911456
125RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.77911456
126cilium morphogenesis (GO:0060271)2.77217720
127rhodopsin mediated signaling pathway (GO:0016056)2.77201904
128regulation of rhodopsin mediated signaling pathway (GO:0022400)2.76723619
129DNA demethylation (GO:0080111)2.76670542
130regulation of action potential (GO:0098900)2.75199448
131microtubule polymerization or depolymerization (GO:0031109)2.75184121
132nephron tubule morphogenesis (GO:0072078)2.74803095
133nephron epithelium morphogenesis (GO:0072088)2.74803095
134negative regulation of organelle assembly (GO:1902116)2.74595357
135cellular component assembly involved in morphogenesis (GO:0010927)2.74133359
136nucleoside diphosphate phosphorylation (GO:0006165)2.74012532
137ubiquinone metabolic process (GO:0006743)2.73233126
138positive regulation of defense response to virus by host (GO:0002230)2.70974214
139neuronal action potential (GO:0019228)2.70917679
140mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.69918619
141interferon-gamma secretion (GO:0072643)2.69757195
142energy coupled proton transport, down electrochemical gradient (GO:0015985)2.68618044
143ATP synthesis coupled proton transport (GO:0015986)2.68618044
144sulfation (GO:0051923)2.68320304
145negative regulation of synaptic transmission, GABAergic (GO:0032229)2.67299309
146pyrimidine ribonucleoside catabolic process (GO:0046133)2.66674239
147primary amino compound metabolic process (GO:1901160)2.66393085
148pyrimidine nucleobase catabolic process (GO:0006208)2.65461109
149mitotic sister chromatid cohesion (GO:0007064)2.60145642
150cytochrome complex assembly (GO:0017004)2.59684965
151retinal cone cell development (GO:0046549)2.58296567
152cellular response to ATP (GO:0071318)2.56443925
153dopamine transport (GO:0015872)2.55988257
154cornea development in camera-type eye (GO:0061303)2.55638172
155DNA methylation (GO:0006306)2.54010373
156DNA alkylation (GO:0006305)2.54010373
157L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.52703053
158maturation of 5.8S rRNA (GO:0000460)2.52555056
159GTP biosynthetic process (GO:0006183)2.52490575
160polyol catabolic process (GO:0046174)2.51253108
161chromatin silencing (GO:0006342)2.50663962
162behavioral response to ethanol (GO:0048149)2.48156684
163regulation of mesoderm development (GO:2000380)2.48131758
164regulation of cilium assembly (GO:1902017)2.46905676
165spinal cord motor neuron differentiation (GO:0021522)2.45840894
166nucleosome disassembly (GO:0006337)2.45297330
167protein-DNA complex disassembly (GO:0032986)2.45297330
168S-adenosylmethionine metabolic process (GO:0046500)2.44402698
169nucleobase catabolic process (GO:0046113)2.43032499
170RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.42692605
171establishment of protein localization to mitochondrial membrane (GO:0090151)2.42034144
172reflex (GO:0060004)2.41953954
173negative regulation of reactive oxygen species metabolic process (GO:2000378)2.41921624
174photoreceptor cell development (GO:0042461)2.41779027
175regulation of telomere maintenance (GO:0032204)2.40582939
176DNA double-strand break processing (GO:0000729)2.40033840
177gamma-aminobutyric acid transport (GO:0015812)2.39451075
178negative regulation of transcription regulatory region DNA binding (GO:2000678)2.38795622
179sperm motility (GO:0030317)12.7008841
180fusion of sperm to egg plasma membrane (GO:0007342)11.6820374
181cell wall macromolecule metabolic process (GO:0044036)11.1697302
182cell wall macromolecule catabolic process (GO:0016998)11.1697302
183acrosome assembly (GO:0001675)11.0109486
184sperm-egg recognition (GO:0035036)10.9153118
185acrosome reaction (GO:0007340)10.8944275
186binding of sperm to zona pellucida (GO:0007339)10.1044807

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.21544481
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.12520619
3GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.22006825
4PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse3.00400012
5GBX2_23144817_ChIP-Seq_PC3_Human2.88056379
6BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.67127554
7IGF1R_20145208_ChIP-Seq_DFB_Human2.58295375
8CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.51872942
9ZFP57_27257070_Chip-Seq_ESCs_Mouse2.44007802
10STAT6_21828071_ChIP-Seq_BEAS2B_Human2.43767672
11VDR_22108803_ChIP-Seq_LS180_Human2.42229896
12ZNF274_21170338_ChIP-Seq_K562_Hela2.28518636
13POU3F2_20337985_ChIP-ChIP_501MEL_Human2.24077130
14TAF15_26573619_Chip-Seq_HEK293_Human2.21958105
15HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.18102273
16EWS_26573619_Chip-Seq_HEK293_Human2.14087422
17GATA1_26923725_Chip-Seq_HPCs_Mouse2.09699340
18FLI1_27457419_Chip-Seq_LIVER_Mouse2.05417871
19MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse10.0770270
20CTBP1_25329375_ChIP-Seq_LNCAP_Human1.99635814
21FUS_26573619_Chip-Seq_HEK293_Human1.98331108
22P300_19829295_ChIP-Seq_ESCs_Human1.96626788
23EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.88442413
24GABP_17652178_ChIP-ChIP_JURKAT_Human1.85163063
25ER_23166858_ChIP-Seq_MCF-7_Human1.83522620
26CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.83260556
27PCGF2_27294783_Chip-Seq_ESCs_Mouse1.80603274
28NOTCH1_21737748_ChIP-Seq_TLL_Human1.79578085
29ELK4_26923725_Chip-Seq_MESODERM_Mouse1.78784476
30KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.70757799
31SALL1_21062744_ChIP-ChIP_HESCs_Human1.65659702
32FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.64506460
33GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.61864880
34GATA3_21867929_ChIP-Seq_CD8_Mouse1.61182641
35IRF1_19129219_ChIP-ChIP_H3396_Human1.60863364
36STAT1_17558387_ChIP-Seq_HELA_Human1.60544202
37UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.60298180
38SOX2_22085726_ChIP-Seq_NPCs_Mouse1.59868054
39MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.59097064
40MYC_18940864_ChIP-ChIP_HL60_Human1.58977044
41BCAT_22108803_ChIP-Seq_LS180_Human1.58348417
42TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.58052479
43ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.56711843
44TP53_22573176_ChIP-Seq_HFKS_Human1.55732608
45RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.54881929
46HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.54587725
47WDR5_24793694_ChIP-Seq_LNCAP_Human1.54581496
48* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.54505606
49EST1_17652178_ChIP-ChIP_JURKAT_Human1.53455438
50CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.51482749
51TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.47696728
52AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.42777670
53PIAS1_25552417_ChIP-Seq_VCAP_Human1.42108942
54FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.42010662
55GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.41463844
56MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.41301225
57FOXA1_27270436_Chip-Seq_PROSTATE_Human1.40878072
58FOXA1_25329375_ChIP-Seq_VCAP_Human1.40878072
59AR_25329375_ChIP-Seq_VCAP_Human1.40803725
60KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.39774088
61STAT3_23295773_ChIP-Seq_U87_Human1.38833550
62RBPJ_22232070_ChIP-Seq_NCS_Mouse1.37543274
63PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.37410378
64GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.36981849
65KAP1_22055183_ChIP-Seq_ESCs_Mouse1.36078214
66REST_21632747_ChIP-Seq_MESCs_Mouse1.35653892
67BMI1_23680149_ChIP-Seq_NPCS_Mouse1.33541156
68SMAD4_21799915_ChIP-Seq_A2780_Human1.33109846
69PCGF2_27294783_Chip-Seq_NPCs_Mouse1.32066757
70GATA3_21878914_ChIP-Seq_MCF-7_Human1.30101022
71NANOG_19829295_ChIP-Seq_ESCs_Human1.29947890
72SOX2_19829295_ChIP-Seq_ESCs_Human1.29947890
73TCF4_23295773_ChIP-Seq_U87_Human1.29653871
74SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.28492437
75SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.27929999
76YY1_22570637_ChIP-Seq_MALME-3M_Human1.27527879
77SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.27415590
78LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.26642519
79TCF4_22108803_ChIP-Seq_LS180_Human1.26631108
80NCOR_22424771_ChIP-Seq_293T_Human1.26361067
81TAL1_26923725_Chip-Seq_HPCs_Mouse1.26288278
82ETV2_25802403_ChIP-Seq_MESCs_Mouse1.25811668
83ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.25557592
84* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.24842906
85KDM2B_26808549_Chip-Seq_REH_Human1.24289189
86RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.24250323
87P53_21459846_ChIP-Seq_SAOS-2_Human1.23990412
88FOXA1_21572438_ChIP-Seq_LNCaP_Human1.23211666
89GATA3_21867929_ChIP-Seq_TH1_Mouse1.22889398
90RUNX1_26923725_Chip-Seq_HPCs_Mouse1.21673446
91NFE2_27457419_Chip-Seq_LIVER_Mouse1.21464606
92SMAD3_21741376_ChIP-Seq_EPCs_Human1.20872463
93EZH2_27294783_Chip-Seq_NPCs_Mouse1.20623696
94CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.19980562
95ERG_20517297_ChIP-Seq_VCAP_Human1.19371189
96TOP2B_26459242_ChIP-Seq_MCF-7_Human1.19113826
97CBP_20019798_ChIP-Seq_JUKART_Human1.18546479
98IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.18546479
99* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.18362520
100CBX2_27304074_Chip-Seq_ESCs_Mouse1.18061446
101TET1_21451524_ChIP-Seq_MESCs_Mouse1.16603793
102* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.15895525
103* SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.15417914
104RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.15304638
105RUNX2_22187159_ChIP-Seq_PCA_Human1.15282224
106FLI1_21867929_ChIP-Seq_TH2_Mouse1.15210621
107RXRA_24833708_ChIP-Seq_LIVER_Mouse1.15108293
108SPI1_26923725_Chip-Seq_HPCs_Mouse1.14569631
109SMAD4_21741376_ChIP-Seq_EPCs_Human1.14339239
110RAD21_21589869_ChIP-Seq_MESCs_Mouse1.13755037
111NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.13642795
112GF1_26923725_Chip-Seq_HPCs_Mouse1.13523951
113AR_20517297_ChIP-Seq_VCAP_Human1.12814798
114E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.12033056
115ELK1_19687146_ChIP-ChIP_HELA_Human1.11102978
116MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.11030025
117* HOXB7_26014856_ChIP-Seq_BT474_Human1.11003467
118VDR_23849224_ChIP-Seq_CD4+_Human1.09409693
119PRDM14_20953172_ChIP-Seq_ESCs_Human1.08657318
120RNF2_27304074_Chip-Seq_NSC_Mouse1.08585682
121CTBP2_25329375_ChIP-Seq_LNCAP_Human1.08426618
122SUZ12_27294783_Chip-Seq_NPCs_Mouse1.07440647
123EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.06249247
124EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.05884078
125EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.05393723
126* RARA_24833708_ChIP-Seq_LIVER_Mouse1.05196820
127CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.04571726
128TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.04023248
129SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.03621409
130SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.02831077
131OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.02718401
132* ESET_19884257_ChIP-Seq_ESCs_Mouse1.02208147
133CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.01811844
134* SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.00983765
135P53_22387025_ChIP-Seq_ESCs_Mouse1.00215658
136MYC_27129775_Chip-Seq_CORNEA_Mouse0.99636177
137POU5F1_16153702_ChIP-ChIP_HESCs_Human0.99611206
138ELF1_20517297_ChIP-Seq_JURKAT_Human0.99187710
139TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.97971810
140POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.97631837
141TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97631837
142TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97247389
143STAT3_18555785_Chip-Seq_ESCs_Mouse0.97094410
144PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.96560837
145NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.96388046
146PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.96305739
147FOXH1_21741376_ChIP-Seq_EPCs_Human0.95861689
148PHF8_20622854_ChIP-Seq_HELA_Human0.95832987
149CRX_20693478_ChIP-Seq_RETINA_Mouse0.95654051
150ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.94627595
151AR_21572438_ChIP-Seq_LNCaP_Human0.94403392
152LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.93766532
153MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.93690567
154* MYC_19829295_ChIP-Seq_ESCs_Human0.93296316
155CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.92563223
156CDX2_22108803_ChIP-Seq_LS180_Human0.92517680
157RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.91863360
158NANOG_18555785_Chip-Seq_ESCs_Mouse0.91771772
159* FLI1_21867929_ChIP-Seq_CD8_Mouse0.91620368
160SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.91474062
161SOX11_22085726_ChIP-Seq_ESNs_Mouse0.91294975
162PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.91062300
163OCT4_18555785_Chip-Seq_ESCs_Mouse0.89921855
164KLF4_18555785_Chip-Seq_ESCs_Mouse0.89181222
165* CTCF_20526341_ChIP-Seq_ESCs_Human0.87937004
166PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.87458056
167* GATA1_19941827_ChIP-Seq_MEL86_Mouse0.87443402
168JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.86180628
169* SOX2_21211035_ChIP-Seq_LN229_Human0.85725103
170ESRRB_18555785_Chip-Seq_ESCs_Mouse0.85637172

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive5.78103539
2MP0001929_abnormal_gametogenesis5.43751830
3MP0008877_abnormal_DNA_methylation5.37286338
4MP0002210_abnormal_sex_determination3.70316063
5MP0001145_abnormal_male_reproductive3.19256313
6MP0002161_abnormal_fertility/fecundity3.17936212
7MP0000569_abnormal_digit_pigmentation2.82568809
8MP0000653_abnormal_sex_gland2.76102583
9MP0001968_abnormal_touch/_nociception2.67345744
10MP0002653_abnormal_ependyma_morphology2.61791826
11MP0006292_abnormal_olfactory_placode2.40371785
12MP0002102_abnormal_ear_morphology2.35268250
13MP0002736_abnormal_nociception_after2.28344507
14MP0004233_abnormal_muscle_weight2.15992053
15MP0005645_abnormal_hypothalamus_physiol2.07161195
16MP0005670_abnormal_white_adipose2.06170827
17MP0002160_abnormal_reproductive_system2.01796568
18MP0005410_abnormal_fertilization14.4336901
19MP0008872_abnormal_physiological_respon1.98302757
20MP0005084_abnormal_gallbladder_morpholo1.93199887
21MP0008058_abnormal_DNA_repair1.92290954
22MP0004142_abnormal_muscle_tone1.90306798
23MP0008875_abnormal_xenobiotic_pharmacok1.82615019
24MP0005646_abnormal_pituitary_gland1.82211978
25MP0009745_abnormal_behavioral_response1.80648284
26MP0002938_white_spotting1.75097051
27MP0003646_muscle_fatigue1.71586497
28MP0004147_increased_porphyrin_level1.69241129
29MP0002272_abnormal_nervous_system1.56410037
30MP0000372_irregular_coat_pigmentation1.53599330
31MP0000427_abnormal_hair_cycle1.50887346
32MP0004885_abnormal_endolymph1.49887510
33MP0002138_abnormal_hepatobiliary_system1.45637591
34MP0004043_abnormal_pH_regulation1.44165924
35MP0001486_abnormal_startle_reflex1.44121714
36MP0002876_abnormal_thyroid_physiology1.39191347
37MP0004742_abnormal_vestibular_system1.37862431
38MP0001905_abnormal_dopamine_level1.36778989
39MP0001501_abnormal_sleep_pattern1.36138287
40MP0006276_abnormal_autonomic_nervous1.34555956
41MP0003136_yellow_coat_color1.33344537
42MP0002572_abnormal_emotion/affect_behav1.32317671
43MP0003880_abnormal_central_pattern1.29911926
44MP0002733_abnormal_thermal_nociception1.29801066
45MP0002557_abnormal_social/conspecific_i1.28155188
46MP0002277_abnormal_respiratory_mucosa1.28124128
47MP0003718_maternal_effect1.27320468
48MP0002735_abnormal_chemical_nociception1.23898629
49MP0001984_abnormal_olfaction1.20669235
50MP0002064_seizures1.20317172
51MP0005623_abnormal_meninges_morphology1.18233157
52MP0005075_abnormal_melanosome_morpholog1.17769750
53MP0005174_abnormal_tail_pigmentation1.17293893
54MP0001986_abnormal_taste_sensitivity1.15833080
55MP0001970_abnormal_pain_threshold1.15731038
56MP0006072_abnormal_retinal_apoptosis1.15653958
57MP0001765_abnormal_ion_homeostasis1.13115067
58MP0005386_behavior/neurological_phenoty1.12576202
59MP0004924_abnormal_behavior1.12576202
60MP0005167_abnormal_blood-brain_barrier1.09614679
61MP0002095_abnormal_skin_pigmentation1.09485123
62MP0008995_early_reproductive_senescence1.08178245
63MP0005389_reproductive_system_phenotype1.07595056
64MP0001485_abnormal_pinna_reflex1.06478140
65MP0010094_abnormal_chromosome_stability1.06348412
66MP0002234_abnormal_pharynx_morphology1.05803097
67MP0003122_maternal_imprinting1.03200145
68MP0003252_abnormal_bile_duct1.03070966
69MP0002067_abnormal_sensory_capabilities1.02654384
70MP0004145_abnormal_muscle_electrophysio1.01700343
71MP0003283_abnormal_digestive_organ1.00715238
72MP0008007_abnormal_cellular_replicative1.00692113
73MP0002751_abnormal_autonomic_nervous0.94950832
74MP0000026_abnormal_inner_ear0.94922408
75MP0003786_premature_aging0.94422710
76MP0002063_abnormal_learning/memory/cond0.91856348
77MP0005377_hearing/vestibular/ear_phenot0.91730944
78MP0003878_abnormal_ear_physiology0.91730944
79MP0003635_abnormal_synaptic_transmissio0.88631418
80MP0005671_abnormal_response_to0.88415379
81MP0008057_abnormal_DNA_replication0.88063891
82MP0002734_abnormal_mechanical_nocicepti0.87727123
83MP0004215_abnormal_myocardial_fiber0.87468826
84MP0008789_abnormal_olfactory_epithelium0.87292252
85MP0005253_abnormal_eye_physiology0.86791002
86MP0009046_muscle_twitch0.83506279
87MP0002752_abnormal_somatic_nervous0.81133420
88MP0005332_abnormal_amino_acid0.80754750
89MP0002282_abnormal_trachea_morphology0.79582822
90MP0000383_abnormal_hair_follicle0.78964089
91MP0000230_abnormal_systemic_arterial0.78846750
92MP0004133_heterotaxia0.78838916
93MP0000778_abnormal_nervous_system0.78141711
94MP0008775_abnormal_heart_ventricle0.76425398
95MP0000049_abnormal_middle_ear0.74503718
96MP0005647_abnormal_sex_gland0.74368715
97MP0002693_abnormal_pancreas_physiology0.73810606
98MP0001963_abnormal_hearing_physiology0.73361174
99MP0002909_abnormal_adrenal_gland0.70237971
100MP0005551_abnormal_eye_electrophysiolog0.66397290
101MP0004036_abnormal_muscle_relaxation0.66327591
102MP0000358_abnormal_cell_content/0.62015861
103MP0005636_abnormal_mineral_homeostasis0.60966593
104MP0002269_muscular_atrophy0.60767642
105MP0001944_abnormal_pancreas_morphology0.60721259
106MP0001661_extended_life_span0.60237464
107MP0006036_abnormal_mitochondrial_physio0.60103257
108MP0003011_delayed_dark_adaptation0.59635534
109MP0003699_abnormal_female_reproductive0.59172173
110MP0001293_anophthalmia0.57020538
111MP0004270_analgesia0.54939450
112MP0003111_abnormal_nucleus_morphology0.54847981
113MP0005391_vision/eye_phenotype0.54144245
114MP0001324_abnormal_eye_pigmentation0.52919767
115MP0001764_abnormal_homeostasis0.50739836
116MP0010386_abnormal_urinary_bladder0.50480187
117MP0002837_dystrophic_cardiac_calcinosis0.49751348
118MP0003787_abnormal_imprinting0.49266674
119MP0003115_abnormal_respiratory_system0.49190307
120MP0004264_abnormal_extraembryonic_tissu0.49066564
121MP0002928_abnormal_bile_duct0.48464127
122MP0001730_embryonic_growth_arrest0.47826826
123MP0001119_abnormal_female_reproductive0.47549328
124MP0001529_abnormal_vocalization0.46153863
125MP0005379_endocrine/exocrine_gland_phen0.45012035
126MP0000678_abnormal_parathyroid_gland0.42268892
127MP0002638_abnormal_pupillary_reflex0.42127772
128MP0003119_abnormal_digestive_system0.41128631
129MP0002084_abnormal_developmental_patter0.38447531
130MP0000534_abnormal_ureter_morphology0.38370495
131MP0000462_abnormal_digestive_system0.38172081
132MP0000631_abnormal_neuroendocrine_gland0.37738921
133MP0000013_abnormal_adipose_tissue0.36158110
134MP0003890_abnormal_embryonic-extraembry0.34770283
135MP0003942_abnormal_urinary_system0.34108039
136MP0003861_abnormal_nervous_system0.33124086
137MP0005423_abnormal_somatic_nervous0.31843341
138MP0003953_abnormal_hormone_level0.30762813
139MP0006035_abnormal_mitochondrial_morpho0.30384052
140MP0002078_abnormal_glucose_homeostasis0.30104444
141MP0002229_neurodegeneration0.29228009
142MP0005195_abnormal_posterior_eye0.29039205
143MP0004019_abnormal_vitamin_homeostasis0.28751750
144MP0005666_abnormal_adipose_tissue0.28283284
145MP0009278_abnormal_bone_marrow0.27405955
146MP0009672_abnormal_birth_weight0.26966982
147MP0000313_abnormal_cell_death0.26665805
148MP0004811_abnormal_neuron_physiology0.26539548
149MP0003195_calcinosis0.26499881
150MP0003077_abnormal_cell_cycle0.25697554
151MP0002085_abnormal_embryonic_tissue0.25524283
152MP0001697_abnormal_embryo_size0.25484896
153MP0003879_abnormal_hair_cell0.25336088
154MP0002163_abnormal_gland_morphology0.25125452
155MP0002108_abnormal_muscle_morphology0.24776526
156MP0001849_ear_inflammation0.24630908
157MP0001672_abnormal_embryogenesis/_devel0.24382123
158MP0005380_embryogenesis_phenotype0.24382123
159MP0003959_abnormal_lean_body0.23695968
160MP0003936_abnormal_reproductive_system0.23503597
161MP0002152_abnormal_brain_morphology0.23272088
162MP0003121_genomic_imprinting0.23027619

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)8.99794357
2Abnormal respiratory epithelium morphology (HP:0012253)8.49948680
3Abnormal respiratory motile cilium morphology (HP:0005938)8.49948680
4Chronic bronchitis (HP:0004469)7.56601639
5Rhinitis (HP:0012384)7.50877729
6Abnormal ciliary motility (HP:0012262)7.04346839
7Infertility (HP:0000789)6.54722869
8Nasal polyposis (HP:0100582)5.94798352
9Abnormality of the nasal mucosa (HP:0000433)4.79586865
10Pancreatic cysts (HP:0001737)4.43570086
11Bronchiectasis (HP:0002110)4.41502497
12Bronchitis (HP:0012387)4.38192186
13Nephronophthisis (HP:0000090)4.33952566
14Male infertility (HP:0003251)4.18465691
15Abnormal spermatogenesis (HP:0008669)3.96757847
16Congenital stationary night blindness (HP:0007642)3.72602157
17Abnormality of the renal medulla (HP:0100957)3.26892648
18Azoospermia (HP:0000027)2.97801623
19Recurrent otitis media (HP:0000403)2.95749170
20Molar tooth sign on MRI (HP:0002419)2.92268208
21Abnormality of midbrain morphology (HP:0002418)2.92268208
22Attenuation of retinal blood vessels (HP:0007843)2.86778950
23Abolished electroretinogram (ERG) (HP:0000550)2.86243187
24Abnormality of alanine metabolism (HP:0010916)2.82471523
25Hyperalaninemia (HP:0003348)2.82471523
26Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.82471523
27Chronic hepatic failure (HP:0100626)2.82186313
28Acute necrotizing encephalopathy (HP:0006965)2.81502817
29Congenital, generalized hypertrichosis (HP:0004540)2.78151171
30Pendular nystagmus (HP:0012043)2.75946724
31Tubular atrophy (HP:0000092)2.74070036
32Hyperventilation (HP:0002883)2.70837196
33Recurrent sinusitis (HP:0011108)2.70236869
34Tubulointerstitial nephritis (HP:0001970)2.69796112
35Mitochondrial inheritance (HP:0001427)2.67205493
36Abnormality of the lower motor neuron (HP:0002366)2.67104261
37Medial flaring of the eyebrow (HP:0010747)2.62714912
38Bile duct proliferation (HP:0001408)2.58840831
39Abnormal biliary tract physiology (HP:0012439)2.58840831
40Impulsivity (HP:0100710)2.57863244
41Gonadotropin excess (HP:0000837)2.54069091
42Increased CSF lactate (HP:0002490)2.46788869
43Renal cortical cysts (HP:0000803)2.46073570
44Abnormal rod and cone electroretinograms (HP:0008323)2.45588263
45Progressive macrocephaly (HP:0004481)2.45090275
46Tubulointerstitial abnormality (HP:0001969)2.44956508
47Acute encephalopathy (HP:0006846)2.37017068
48Abnormal mitochondria in muscle tissue (HP:0008316)2.33983561
49Inability to walk (HP:0002540)2.33944714
50Sclerocornea (HP:0000647)2.33903718
51Hepatocellular necrosis (HP:0001404)2.31682236
523-Methylglutaconic aciduria (HP:0003535)2.29880131
53Hepatic necrosis (HP:0002605)2.27012551
54Polydipsia (HP:0001959)2.26351910
55Abnormal drinking behavior (HP:0030082)2.26351910
56Abnormality of the pons (HP:0007361)2.26295354
57Increased corneal curvature (HP:0100692)2.26118382
58Keratoconus (HP:0000563)2.26118382
59Recurrent bronchitis (HP:0002837)2.25919217
60Optic disc pallor (HP:0000543)2.22937915
61Facial cleft (HP:0002006)2.21943259
62Progressive inability to walk (HP:0002505)2.19483634
63Lissencephaly (HP:0001339)2.16390797
64Large for gestational age (HP:0001520)2.14186149
65Lipid accumulation in hepatocytes (HP:0006561)2.13693345
66Hypothermia (HP:0002045)2.11589483
67Postaxial foot polydactyly (HP:0001830)2.10772758
68Hypoplasia of the pons (HP:0012110)2.10215126
69Tubulointerstitial fibrosis (HP:0005576)2.07004176
70Increased hepatocellular lipid droplets (HP:0006565)2.05614044
71Decreased electroretinogram (ERG) amplitude (HP:0000654)2.03789942
72Male pseudohermaphroditism (HP:0000037)2.02515887
73Anencephaly (HP:0002323)2.02447754
74Concave nail (HP:0001598)2.02395905
75Congenital hepatic fibrosis (HP:0002612)2.01802466
76Furrowed tongue (HP:0000221)2.01643985
77Gaze-evoked nystagmus (HP:0000640)2.00804592
78Renal Fanconi syndrome (HP:0001994)2.00558038
79Fibular hypoplasia (HP:0003038)2.00317417
80Respiratory insufficiency due to defective ciliary clearance (HP:0200073)12.7841536
81Dynein arm defect of respiratory motile cilia (HP:0012255)11.9106005
82Absent/shortened dynein arms (HP:0200106)11.9106005
83Birth length less than 3rd percentile (HP:0003561)1.97924679
84Fair hair (HP:0002286)1.97714412
85Stage 5 chronic kidney disease (HP:0003774)1.97692346
86Cholecystitis (HP:0001082)1.95757724
87Abnormal gallbladder physiology (HP:0012438)1.95757724
88Progressive cerebellar ataxia (HP:0002073)1.94822576
89Pachygyria (HP:0001302)1.92424379
90Amyotrophic lateral sclerosis (HP:0007354)1.91404439
91Hyperinsulinemic hypoglycemia (HP:0000825)1.91066626
92Optic nerve hypoplasia (HP:0000609)1.90732464
93Broad-based gait (HP:0002136)1.90548630
94Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.88961530
95Abnormality of renal excretion (HP:0011036)1.86997009
96Nephrogenic diabetes insipidus (HP:0009806)1.86955807
97Stomach cancer (HP:0012126)1.86830017
98Hypoplasia of the capital femoral epiphysis (HP:0003090)1.86031657
99Hypomagnesemia (HP:0002917)1.85710539
100Severe muscular hypotonia (HP:0006829)1.85115567
101Bony spicule pigmentary retinopathy (HP:0007737)1.84686219
102Generalized aminoaciduria (HP:0002909)1.83808623
103Aplasia/Hypoplasia of the tibia (HP:0005772)1.83019568
104Renal dysplasia (HP:0000110)1.82745679
105Hyperglycinuria (HP:0003108)1.82585788
106Short ribs (HP:0000773)1.81746907
107Aplasia/Hypoplasia of the spleen (HP:0010451)1.81518995
108Bilateral microphthalmos (HP:0007633)1.81472693
109Dyschromatopsia (HP:0007641)1.80279485
110Absent rod-and cone-mediated responses on ERG (HP:0007688)1.78941612
111Absent speech (HP:0001344)1.78825014
112Oculomotor apraxia (HP:0000657)1.78196415
113Median cleft lip (HP:0000161)1.77418140
114Genital tract atresia (HP:0001827)1.77330628
115Methylmalonic acidemia (HP:0002912)1.77158262
116Intestinal atresia (HP:0011100)1.75929676
117Increased serum lactate (HP:0002151)1.75771018
118Pancreatic fibrosis (HP:0100732)1.74408084
119Cystic liver disease (HP:0006706)1.73833476
120Limb dystonia (HP:0002451)1.73635181
121Abnormality of macular pigmentation (HP:0008002)1.73272306
122Abnormality of the renal cortex (HP:0011035)1.73023043
123Febrile seizures (HP:0002373)1.72577302
124Focal motor seizures (HP:0011153)1.71769050
125Postaxial hand polydactyly (HP:0001162)1.68649721
126Abnormal urine output (HP:0012590)1.67109130
127Spastic tetraparesis (HP:0001285)1.64471796
128Decreased central vision (HP:0007663)1.62048486
129Polyuria (HP:0000103)1.57762794
130Short thorax (HP:0010306)1.56477629
131Aplasia/Hypoplasia of the lens (HP:0008063)1.54799499
132Supernumerary spleens (HP:0009799)1.49069656
133Choroideremia (HP:0001139)1.47731864
134Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.46712187
135Myoglobinuria (HP:0002913)1.45554237
136Congenital primary aphakia (HP:0007707)1.41380260
137Abnormality of the dental root (HP:0006486)1.41140775
138Taurodontia (HP:0000679)1.41140775
139Abnormality of permanent molar morphology (HP:0011071)1.41140775
140Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.40386160
141Absent epiphyses (HP:0010577)1.40386160
142Abnormality of the anterior horn cell (HP:0006802)1.40219938
143Degeneration of anterior horn cells (HP:0002398)1.40219938
144Abnormality of the dental pulp (HP:0006479)1.39601678
145Gait imbalance (HP:0002141)1.39601653
146Nephropathy (HP:0000112)1.39315790
147Aplasia/Hypoplasia of the fibula (HP:0006492)1.38855058
148Cerebellar dysplasia (HP:0007033)1.38314962
149Asymmetric septal hypertrophy (HP:0001670)1.38287761
150Heterotopia (HP:0002282)1.37095343
151Bell-shaped thorax (HP:0001591)1.36857954
152Exercise-induced myalgia (HP:0003738)1.36836195
153Abnormality of dentin (HP:0010299)1.36809455
154Impaired proprioception (HP:0010831)1.35673959
155Occipital encephalocele (HP:0002085)1.33833272
156Double outlet right ventricle (HP:0001719)1.33219251
157Congenital malformation of the right heart (HP:0011723)1.33219251
158Aplasia/Hypoplasia of the tongue (HP:0010295)1.32927438
159Hyperkalemia (HP:0002153)1.31812353
160Aplasia/Hypoplasia affecting the retina (HP:0008061)1.31538827
16111 pairs of ribs (HP:0000878)1.31304824
162Abnormality of molar morphology (HP:0011070)1.27399154
163Abnormality of molar (HP:0011077)1.27399154
164Neurofibrillary tangles (HP:0002185)1.27297042
165True hermaphroditism (HP:0010459)1.27055042
166Constricted visual fields (HP:0001133)1.25640744
167EMG: neuropathic changes (HP:0003445)1.25330121
168Type II lissencephaly (HP:0007260)1.24148818
169Bundle branch block (HP:0011710)1.23882319
170Type II diabetes mellitus (HP:0005978)1.23130669
171Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.21962082

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK37.71537179
2PDK47.71537179
3PRKD36.18957412
4TESK15.83451990
5PDK24.94134203
6ICK3.80580341
7TLK13.36944008
8ADRBK23.14448318
9WNK42.91631036
10GRK12.52589418
11ZAK2.49794464
12TAOK32.46828217
13NUAK12.33986901
14STK392.11204121
15MAP4K22.09100262
16PTK2B2.04725471
17OXSR11.98954854
18STK381.97841860
19CASK1.82743273
20MAPK131.81463105
21TXK1.72587634
22PASK1.64531824
23NEK21.60246142
24PIK3CA1.57062429
25MAPK151.54192434
26STK38L1.49779763
27DYRK1B1.46527729
28DAPK21.45441621
29CDK191.41888433
30PNCK1.37870208
31MKNK21.37439564
32TIE11.24465565
33KIT1.20872949
34ADRBK11.18330097
35PAK31.12564068
36CAMKK21.11544703
37DYRK21.08146122
38MAP2K71.07087585
39VRK11.06282581
40TNIK1.05215975
41MARK11.04667003
42VRK21.03622928
43FLT31.03071280
44WNK11.02133844
45DYRK30.98079072
46BCKDK0.96386335
47PINK10.93740239
48TGFBR10.92215302
49PDK10.90613611
50PRKCE0.88135630
51CDC70.84117346
52PLK20.82947891
53TTK0.82149843
54TRIM280.81171253
55MKNK10.80813970
56ACVR1B0.75640087
57TEC0.74538567
58IRAK10.73147969
59CHEK20.72821166
60BMPR1B0.72172940
61CSNK1G10.70749206
62EPHA30.70265696
63TYRO30.69968165
64PRKCQ0.68703197
65PHKG10.68677692
66PHKG20.68677692
67TAF10.66603022
68CSNK1G20.65091440
69NTRK30.63932268
70EPHA40.62000270
71IKBKB0.61939504
72CSNK1G30.61284903
73MST40.59882487
74RPS6KA50.58262023
75MAPKAPK30.57786091
76PKN10.57639846
77ATR0.57009596
78CCNB10.56452021
79ITK0.55125056
80CHEK10.53975602
81STK30.53906545
82INSRR0.53799026
83PDPK10.52648830
84BCR0.52359656
85PLK30.50527723
86FRK0.50502072
87NLK0.49827639
88BRSK20.49519953
89ERBB30.49346994
90NME10.48146308
91WNK30.45125899
92FGFR20.43321600
93GRK70.42914009
94CAMK10.42536414
95ATM0.42386908
96STK110.40495622
97CSNK1A1L0.39121704
98DYRK1A0.38988200
99PRKCI0.38382083
100TNK20.38035085
101MAP2K40.37995596
102PRKAA10.37898806
103WEE10.37688406
104SYK0.37678726
105PRKCG0.37132524
106CSF1R0.37116187
107CAMK1G0.36937575
108PRKG10.36204387
109GRK50.35969951
110IRAK20.35672761
111PLK10.34511732
112CSNK1A10.34474362
113NTRK20.33612152
114RPS6KB10.33455609
115CHUK0.33402228
116MTOR0.32902954
117OBSCN0.32683556
118PRKD20.32041994
119BUB10.28948428
120PLK40.28755664
121PAK60.26546153
122PAK10.24943130
123BRAF0.24883291
124MUSK0.24184429
125CDK120.22687482
126BRSK10.22666294
127PRKCZ0.22136417
128MAP2K60.20409519
129CDC42BPA0.17792868
130LMTK20.17562522
131MARK20.15562476
132PAK20.15447468
133CSNK2A10.14492335
134CSNK2A20.13044535
135NEK60.12992777
136RPS6KA10.12926786
137GSK3B0.12485328
138AURKA0.12445220
139CDK20.11864963
140PRKACG0.10276211
141CDK10.10065545
142HIPK20.09877980
143EEF2K0.08678447
144CDK30.08006582
145PAK40.07809277
146PRKDC0.07805216
147CDK150.07130054
148MAPKAPK50.06334831
149TESK20.05619952
150CDK180.04840292
151CAMK2A0.04784459
152PRKACA0.04318318
153PRKCD0.04312142
154UHMK10.04190253
155PRKCH0.04093482
156PRKCA0.03800435
157PRKACB0.03787865
158RPS6KA30.03389311
159PRKCB0.03251829
160MAPK80.03163638
161CDK11A0.03148803
162CDK140.02105249
163MAPK100.02010927
164PRKG20.01886184
165MET0.01710247
166MAP3K40.01530438
167BMPR20.01334721
168STK160.01218598
169MAP3K100.01144786
170MARK30.00565213
171RIPK40.00493210
172MAP3K50.00486700

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.21875761
2Pyruvate metabolism_Homo sapiens_hsa006203.50810827
3Fatty acid biosynthesis_Homo sapiens_hsa000613.42769882
4Vitamin B6 metabolism_Homo sapiens_hsa007503.09955503
5Basal transcription factors_Homo sapiens_hsa030222.99639647
6Glucagon signaling pathway_Homo sapiens_hsa049222.84098341
7Oxidative phosphorylation_Homo sapiens_hsa001902.79527420
8Phototransduction_Homo sapiens_hsa047442.74237278
9Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.73897334
10Selenocompound metabolism_Homo sapiens_hsa004502.62013773
11Nitrogen metabolism_Homo sapiens_hsa009102.60554814
12Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.55187803
13Propanoate metabolism_Homo sapiens_hsa006402.48046928
14Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.37532574
15Maturity onset diabetes of the young_Homo sapiens_hsa049502.35641556
16Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.32334142
17Carbohydrate digestion and absorption_Homo sapiens_hsa049732.27796780
18Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.25246154
19Butanoate metabolism_Homo sapiens_hsa006502.21050305
20Parkinsons disease_Homo sapiens_hsa050122.15898887
21Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.10089152
22Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.09908797
23Caffeine metabolism_Homo sapiens_hsa002322.04252695
24Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.02948109
25Fanconi anemia pathway_Homo sapiens_hsa034602.02003227
26Fructose and mannose metabolism_Homo sapiens_hsa000512.01314010
27RNA polymerase_Homo sapiens_hsa030201.90376524
28Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.87680626
29Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.76122949
30Tryptophan metabolism_Homo sapiens_hsa003801.75836482
31Glycerolipid metabolism_Homo sapiens_hsa005611.69281785
32Intestinal immune network for IgA production_Homo sapiens_hsa046721.68856172
33Nicotine addiction_Homo sapiens_hsa050331.66591625
34Pentose phosphate pathway_Homo sapiens_hsa000301.62026639
35Amphetamine addiction_Homo sapiens_hsa050311.61792522
36Glycosaminoglycan degradation_Homo sapiens_hsa005311.61412364
37Oocyte meiosis_Homo sapiens_hsa041141.58692196
38Asthma_Homo sapiens_hsa053101.57994101
39Insulin secretion_Homo sapiens_hsa049111.55393681
40Carbon metabolism_Homo sapiens_hsa012001.44006776
41One carbon pool by folate_Homo sapiens_hsa006701.43747540
42Huntingtons disease_Homo sapiens_hsa050161.43411019
43RNA transport_Homo sapiens_hsa030131.40768656
44* alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.39900138
45Cysteine and methionine metabolism_Homo sapiens_hsa002701.39544656
46Dorso-ventral axis formation_Homo sapiens_hsa043201.39159867
47Olfactory transduction_Homo sapiens_hsa047401.38716359
48Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.38485937
49Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.36990261
50Alzheimers disease_Homo sapiens_hsa050101.35515176
51Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.34278719
52Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.33878553
53* Linoleic acid metabolism_Homo sapiens_hsa005911.31827387
54mRNA surveillance pathway_Homo sapiens_hsa030151.31755836
55Type I diabetes mellitus_Homo sapiens_hsa049401.30403016
56Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.30270784
57Allograft rejection_Homo sapiens_hsa053301.30197321
58Graft-versus-host disease_Homo sapiens_hsa053321.29295959
59Autoimmune thyroid disease_Homo sapiens_hsa053201.27022447
60Cardiac muscle contraction_Homo sapiens_hsa042601.26118366
61Ribosome_Homo sapiens_hsa030101.26074549
62Mineral absorption_Homo sapiens_hsa049781.25362871
63Purine metabolism_Homo sapiens_hsa002301.19719207
64Sulfur metabolism_Homo sapiens_hsa009201.15702241
65PPAR signaling pathway_Homo sapiens_hsa033201.14166464
66Collecting duct acid secretion_Homo sapiens_hsa049661.13591891
67* Glycerophospholipid metabolism_Homo sapiens_hsa005641.12953079
68Fatty acid metabolism_Homo sapiens_hsa012121.12644429
69Fatty acid degradation_Homo sapiens_hsa000711.11310401
70Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.10187581
71Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.08975798
72Morphine addiction_Homo sapiens_hsa050321.06902374
73Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.06471619
74Primary bile acid biosynthesis_Homo sapiens_hsa001201.06054587
75Biosynthesis of amino acids_Homo sapiens_hsa012301.04297842
76Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.01204907
77Peroxisome_Homo sapiens_hsa041460.98654866
78Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.96798782
79Steroid hormone biosynthesis_Homo sapiens_hsa001400.96095296
80Retinol metabolism_Homo sapiens_hsa008300.94565534
81Glutathione metabolism_Homo sapiens_hsa004800.94373064
82Protein export_Homo sapiens_hsa030600.92181052
83Renin secretion_Homo sapiens_hsa049240.89506454
84Antigen processing and presentation_Homo sapiens_hsa046120.87629787
85Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.85657353
86Serotonergic synapse_Homo sapiens_hsa047260.84874117
87beta-Alanine metabolism_Homo sapiens_hsa004100.81486951
88Hedgehog signaling pathway_Homo sapiens_hsa043400.81042838
89ABC transporters_Homo sapiens_hsa020100.80532452
90Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.79668140
91Long-term potentiation_Homo sapiens_hsa047200.78236694
92Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.78166011
93Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.77737512
94* Arachidonic acid metabolism_Homo sapiens_hsa005900.75843878
95Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.75379819
96GABAergic synapse_Homo sapiens_hsa047270.75355731
97Thyroid hormone synthesis_Homo sapiens_hsa049180.73297860
98Homologous recombination_Homo sapiens_hsa034400.72733943
99Synaptic vesicle cycle_Homo sapiens_hsa047210.72673781
100Rheumatoid arthritis_Homo sapiens_hsa053230.71450267
101Central carbon metabolism in cancer_Homo sapiens_hsa052300.71302867
102Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.70756713
103Taste transduction_Homo sapiens_hsa047420.69146735
104Glutamatergic synapse_Homo sapiens_hsa047240.68720993
105cGMP-PKG signaling pathway_Homo sapiens_hsa040220.68194692
106Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.67980868
107Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.67578638
108Primary immunodeficiency_Homo sapiens_hsa053400.67345546
109Renin-angiotensin system_Homo sapiens_hsa046140.65770540
110Regulation of autophagy_Homo sapiens_hsa041400.62320262
111Estrogen signaling pathway_Homo sapiens_hsa049150.62304086
112RNA degradation_Homo sapiens_hsa030180.62253025
113Ovarian steroidogenesis_Homo sapiens_hsa049130.61569604
114Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.59949346
115Chemical carcinogenesis_Homo sapiens_hsa052040.58605201
116AMPK signaling pathway_Homo sapiens_hsa041520.56113717
117Alcoholism_Homo sapiens_hsa050340.55150580
118Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.54649616
119Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.53872509
120Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.53220502
121SNARE interactions in vesicular transport_Homo sapiens_hsa041300.52153995
122Adipocytokine signaling pathway_Homo sapiens_hsa049200.52053154
123Type II diabetes mellitus_Homo sapiens_hsa049300.51682704
124Cocaine addiction_Homo sapiens_hsa050300.51233575
125Salivary secretion_Homo sapiens_hsa049700.51225080
126Base excision repair_Homo sapiens_hsa034100.51176696
127Steroid biosynthesis_Homo sapiens_hsa001000.49887191
128Pyrimidine metabolism_Homo sapiens_hsa002400.49190127
129Systemic lupus erythematosus_Homo sapiens_hsa053220.48068098
130* Metabolic pathways_Homo sapiens_hsa011000.47159814
131DNA replication_Homo sapiens_hsa030300.46676895
132Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.45058251
133N-Glycan biosynthesis_Homo sapiens_hsa005100.44957543
134Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.43100281
135Non-homologous end-joining_Homo sapiens_hsa034500.41507338
136Inositol phosphate metabolism_Homo sapiens_hsa005620.40563149
137Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.39461325
138Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.36233683
139Legionellosis_Homo sapiens_hsa051340.36042444
140Bile secretion_Homo sapiens_hsa049760.35083516
141Cell cycle_Homo sapiens_hsa041100.35016572
142Dopaminergic synapse_Homo sapiens_hsa047280.34847108
143Protein digestion and absorption_Homo sapiens_hsa049740.34156760
144Calcium signaling pathway_Homo sapiens_hsa040200.33584780
145Long-term depression_Homo sapiens_hsa047300.33566906
146African trypanosomiasis_Homo sapiens_hsa051430.33332000
147Vitamin digestion and absorption_Homo sapiens_hsa049770.33224346
148Vibrio cholerae infection_Homo sapiens_hsa051100.33009699
149NOD-like receptor signaling pathway_Homo sapiens_hsa046210.30622076
150* Fat digestion and absorption_Homo sapiens_hsa049750.30454133
151Phosphatidylinositol signaling system_Homo sapiens_hsa040700.30362059
152Thyroid hormone signaling pathway_Homo sapiens_hsa049190.30318709
153Endocytosis_Homo sapiens_hsa041440.29080531
154Sphingolipid metabolism_Homo sapiens_hsa006000.28330761
155Pentose and glucuronate interconversions_Homo sapiens_hsa000400.26404868
156Proteasome_Homo sapiens_hsa030500.25425436
157Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.24985397
158Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.24257515
159* Ether lipid metabolism_Homo sapiens_hsa005650.22865449
160Circadian entrainment_Homo sapiens_hsa047130.21363753
161Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.19234789

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