PLA2G2D

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a secreted member of the phospholipase A2 family, and is found in a cluster of related family members on chromosome 1. Phospholipase A2 family members hydrolyze the sn-2 fatty acid ester bond of glycerophospholipids to produce lysophospholipids and free fatty acid. This gene may be involved in inflammation and immune response, and in weight loss associated with chronic obstructive pulmonary disease. Alternative splicing results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of mast cell activation (GO:0033004)4.77448830
2L-fucose catabolic process (GO:0042355)4.75194338
3fucose catabolic process (GO:0019317)4.75194338
4L-fucose metabolic process (GO:0042354)4.75194338
5positive regulation of respiratory burst (GO:0060267)4.73617137
6positive regulation of glycoprotein biosynthetic process (GO:0010560)3.86242200
7regulation of cellular extravasation (GO:0002691)3.82091907
8regulation of guanylate cyclase activity (GO:0031282)3.78302225
9superoxide anion generation (GO:0042554)3.62633801
10alkaloid metabolic process (GO:0009820)3.61331822
11dendritic cell chemotaxis (GO:0002407)3.59384766
12detection of other organism (GO:0098543)3.56328109
13indole-containing compound catabolic process (GO:0042436)3.48735685
14indolalkylamine catabolic process (GO:0046218)3.48735685
15tryptophan catabolic process (GO:0006569)3.48735685
16drug catabolic process (GO:0042737)3.47028970
17complement activation, classical pathway (GO:0006958)3.46577805
18DNA deamination (GO:0045006)3.38537565
19positive regulation of guanylate cyclase activity (GO:0031284)3.38436909
20positive regulation of cellular amide metabolic process (GO:0034250)3.36173812
21cellular response to interferon-beta (GO:0035458)3.35483375
22water-soluble vitamin biosynthetic process (GO:0042364)3.34430717
23histamine secretion (GO:0001821)3.34010711
24regulation of nuclear cell cycle DNA replication (GO:0033262)3.30725276
25G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.29087950
26indolalkylamine metabolic process (GO:0006586)3.25524972
27kynurenine metabolic process (GO:0070189)3.24101651
28regulation of dendritic cell antigen processing and presentation (GO:0002604)3.21836627
29platelet dense granule organization (GO:0060155)3.13815497
30exogenous drug catabolic process (GO:0042738)3.09485717
31positive regulation of antigen processing and presentation (GO:0002579)3.09393112
32production of molecular mediator involved in inflammatory response (GO:0002532)3.09297943
33activated T cell proliferation (GO:0050798)3.07881456
34lipoxygenase pathway (GO:0019372)3.06758001
35detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.05086505
36regulation of mast cell activation (GO:0033003)3.05010841
37natural killer cell activation involved in immune response (GO:0002323)3.02476093
38energy homeostasis (GO:0097009)3.02063819
39positive regulation of T-helper 1 type immune response (GO:0002827)3.01009465
40killing of cells of other organism (GO:0031640)3.00233549
41disruption of cells of other organism (GO:0044364)3.00233549
42regulation of activation of Janus kinase activity (GO:0010533)3.00201421
43dendritic cell migration (GO:0036336)2.99895150
44* phosphatidylinositol acyl-chain remodeling (GO:0036149)2.99597952
45response to pheromone (GO:0019236)2.98551397
46arginine metabolic process (GO:0006525)2.98441291
47regulation of B cell receptor signaling pathway (GO:0050855)2.94258706
48sulfation (GO:0051923)2.93871176
49interferon-gamma production (GO:0032609)2.93861037
50detection of bacterium (GO:0016045)2.93771896
51* phosphatidylcholine acyl-chain remodeling (GO:0036151)2.91898178
52signal peptide processing (GO:0006465)2.91807943
53positive regulation of glycoprotein metabolic process (GO:1903020)2.89234103
54detection of molecule of bacterial origin (GO:0032490)2.88998780
55regulation of antigen processing and presentation (GO:0002577)2.88885149
56tryptophan metabolic process (GO:0006568)2.86998873
57cytidine deamination (GO:0009972)2.86737990
58cytidine metabolic process (GO:0046087)2.86737990
59cytidine catabolic process (GO:0006216)2.86737990
60negative regulation of telomere maintenance (GO:0032205)2.84850633
61regulation of respiratory burst (GO:0060263)2.84269793
62regulation of mast cell activation involved in immune response (GO:0033006)2.81343669
63response to peptidoglycan (GO:0032494)2.80510684
64GPI anchor biosynthetic process (GO:0006506)2.78394369
65behavioral response to nicotine (GO:0035095)2.77298129
66epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.73858136
67behavioral response to ethanol (GO:0048149)2.73580344
68* phosphatidylserine acyl-chain remodeling (GO:0036150)2.73148661
69regulation of mast cell degranulation (GO:0043304)2.72813939
70mesenchymal cell differentiation involved in renal system development (GO:2001012)2.72734807
71mesenchymal cell differentiation involved in kidney development (GO:0072161)2.72734807
72antibacterial humoral response (GO:0019731)2.72502634
73complement activation (GO:0006956)2.71781010
74* phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.71354948
75cytochrome complex assembly (GO:0017004)2.70814656
76endosome to melanosome transport (GO:0035646)2.70254469
77endosome to pigment granule transport (GO:0043485)2.70254469
78histone H3-K4 trimethylation (GO:0080182)2.70094111
79antigen processing and presentation of endogenous antigen (GO:0019883)2.68938811
80fucosylation (GO:0036065)2.68217583
81negative regulation of DNA-dependent DNA replication (GO:2000104)2.67987766
82angiotensin maturation (GO:0002003)2.66494830
83* phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.65520912
84glomerular filtration (GO:0003094)2.65002165
85regulation of timing of cell differentiation (GO:0048505)2.63305124
86cellular biogenic amine catabolic process (GO:0042402)2.62881193
87amine catabolic process (GO:0009310)2.62881193
88regulation of cGMP biosynthetic process (GO:0030826)2.62266179
89positive regulation of T cell migration (GO:2000406)2.62247691
90neural tube formation (GO:0001841)2.62102580
91retinal cone cell development (GO:0046549)2.61574670
92daunorubicin metabolic process (GO:0044597)2.61559916
93polyketide metabolic process (GO:0030638)2.61559916
94doxorubicin metabolic process (GO:0044598)2.61559916
95thyroid hormone metabolic process (GO:0042403)2.61409452
96arginine catabolic process (GO:0006527)2.61225959
97detection of external biotic stimulus (GO:0098581)2.61072173
98piRNA metabolic process (GO:0034587)2.60973540
99purinergic nucleotide receptor signaling pathway (GO:0035590)2.59878343
100positive regulation of interleukin-1 beta secretion (GO:0050718)2.59500705
101developmental pigmentation (GO:0048066)2.59004670
102cell differentiation involved in metanephros development (GO:0072202)2.58776612
103positive regulation of pseudopodium assembly (GO:0031274)2.58055164
104positive regulation of neutrophil chemotaxis (GO:0090023)2.57564420
105positive regulation of neutrophil migration (GO:1902624)2.57564420
106histamine transport (GO:0051608)2.55605431
107organic cation transport (GO:0015695)2.55143104
108axoneme assembly (GO:0035082)2.54426448
109protein heterotetramerization (GO:0051290)2.53911120
110auditory receptor cell stereocilium organization (GO:0060088)2.53235017
111leukotriene biosynthetic process (GO:0019370)2.52489379
112kidney morphogenesis (GO:0060993)2.51780426
113respiratory chain complex IV assembly (GO:0008535)2.51324496
114pyrimidine ribonucleoside catabolic process (GO:0046133)2.50889365
115nucleotide-binding oligomerization domain containing signaling pathway (GO:0070423)2.50655437
116positive regulation of fatty acid transport (GO:2000193)2.50531332
117antimicrobial humoral response (GO:0019730)2.50342319
118negative regulation of phagocytosis (GO:0050765)2.50117404
119antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.48155166
120mannosylation (GO:0097502)2.47520258
121leukotriene metabolic process (GO:0006691)2.47149333
122positive regulation of defense response to virus by host (GO:0002230)2.46874445
123positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.46611008
124protein K11-linked deubiquitination (GO:0035871)2.46421006
125regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.45984368
126cellular response to exogenous dsRNA (GO:0071360)2.45378328
127I-kappaB kinase/NF-kappaB signaling (GO:0007249)2.45062184
128regulation of T-helper 1 type immune response (GO:0002825)2.44510452
129GPI anchor metabolic process (GO:0006505)2.44291819
130cellular ketone body metabolic process (GO:0046950)2.43244693
131dopamine transport (GO:0015872)2.42832422
132positive regulation of toll-like receptor signaling pathway (GO:0034123)2.42806231
133regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.42753080
134modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.42257078
135positive regulation by organism of defense response of other organism involved in symbiotic interact2.42257078
136modulation by symbiont of host immune response (GO:0052553)2.42257078
137positive regulation by symbiont of host defense response (GO:0052509)2.42257078
138modulation by symbiont of host defense response (GO:0052031)2.42257078
139modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.42257078
140negative regulation of leukocyte migration (GO:0002686)2.40719527
141photoreceptor cell maintenance (GO:0045494)2.40707662
142positive regulation of T cell chemotaxis (GO:0010820)2.39545434
143regulation of T cell chemotaxis (GO:0010819)2.39545434
144positive regulation of mast cell degranulation (GO:0043306)2.38981933
145positive regulation of mast cell activation involved in immune response (GO:0033008)2.38981933
146regulation of neutrophil migration (GO:1902622)2.38548106
147regulation of neutrophil chemotaxis (GO:0090022)2.38548106
148positive regulation of growth hormone secretion (GO:0060124)2.37560964
149parturition (GO:0007567)2.37536966
150transepithelial transport (GO:0070633)2.37140073
151neuronal action potential (GO:0019228)2.37084846
152drug metabolic process (GO:0017144)2.36887353
153lymph node development (GO:0048535)2.36536457
154regulation of T cell migration (GO:2000404)2.36111234
155nucleobase catabolic process (GO:0046113)2.34842554
156proline transport (GO:0015824)2.33821769
157positive regulation of interleukin-12 production (GO:0032735)2.33772092
158eosinophil migration (GO:0072677)2.33474248
159detection of light stimulus involved in sensory perception (GO:0050962)2.33472486
160poly(A)+ mRNA export from nucleus (GO:0016973)2.33048077
161positive regulation of interleukin-1 secretion (GO:0050716)2.32949556
162tRNA methylation (GO:0030488)2.32879276
163negative regulation of myoblast differentiation (GO:0045662)2.32834738
164positive regulation of mast cell activation (GO:0033005)2.30475659
165cellular response to interleukin-15 (GO:0071350)2.29746587
166regulation of chemokine secretion (GO:0090196)2.29411030
167extracellular negative regulation of signal transduction (GO:1900116)2.29377556
168extracellular regulation of signal transduction (GO:1900115)2.29377556
169regulation of interleukin-6 biosynthetic process (GO:0045408)2.28889363
170glycosphingolipid catabolic process (GO:0046479)2.27927982
171facial nerve structural organization (GO:0021612)2.27423785
172regulation of interleukin-8 secretion (GO:2000482)2.27133122
173positive regulation of smooth muscle cell migration (GO:0014911)2.27120276
174interleukin-1-mediated signaling pathway (GO:0070498)2.27100373
175nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway (GO:0035872)2.26399341
176regulation of interleukin-12 biosynthetic process (GO:0045075)2.26380111
177neutrophil activation (GO:0042119)2.25918471
178regulation of development, heterochronic (GO:0040034)2.24806071
179superoxide metabolic process (GO:0006801)2.23667780
180positive regulation of lymphocyte migration (GO:2000403)2.23057769
181eosinophil chemotaxis (GO:0048245)2.22639827
182regulation of male gonad development (GO:2000018)2.22530435
183positive regulation of monocyte chemotaxis (GO:0090026)2.21789549
184sphingoid metabolic process (GO:0046519)2.19943065
185response to interferon-beta (GO:0035456)2.19185184
186amino sugar catabolic process (GO:0046348)2.18812468
187cytoplasmic pattern recognition receptor signaling pathway (GO:0002753)2.18436327

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.58579117
2ZNF274_21170338_ChIP-Seq_K562_Hela3.55698893
3IRF8_21731497_ChIP-ChIP_J774_Mouse3.48722835
4GBX2_23144817_ChIP-Seq_PC3_Human3.42172658
5IRF8_22096565_ChIP-ChIP_GC-B_Human3.21875726
6IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.11657246
7GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.06727349
8BP1_19119308_ChIP-ChIP_Hs578T_Human3.06697099
9PCGF2_27294783_Chip-Seq_ESCs_Mouse2.72905873
10FLI1_27457419_Chip-Seq_LIVER_Mouse2.56986054
11EZH2_22144423_ChIP-Seq_EOC_Human2.50832241
12ZFP57_27257070_Chip-Seq_ESCs_Mouse2.37937160
13ELF1_17652178_ChIP-ChIP_JURKAT_Human2.36822473
14HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.34992779
15CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.17594479
16SUZ12_27294783_Chip-Seq_NPCs_Mouse2.15652136
17FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.14159976
18NFE2_27457419_Chip-Seq_LIVER_Mouse2.11507112
19IGF1R_20145208_ChIP-Seq_DFB_Human2.11086926
20PCGF2_27294783_Chip-Seq_NPCs_Mouse2.06455268
21BMI1_23680149_ChIP-Seq_NPCS_Mouse2.06204468
22STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.04831326
23STAT3_18555785_Chip-Seq_ESCs_Mouse2.01881314
24SUZ12_18555785_Chip-Seq_ESCs_Mouse1.98838623
25CTBP1_25329375_ChIP-Seq_LNCAP_Human1.91032435
26EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.87970541
27NMYC_18555785_Chip-Seq_ESCs_Mouse1.86531931
28EZH2_27294783_Chip-Seq_NPCs_Mouse1.86349629
29P53_22387025_ChIP-Seq_ESCs_Mouse1.85245899
30POU3F2_20337985_ChIP-ChIP_501MEL_Human1.84413817
31LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.83969148
32GATA1_22025678_ChIP-Seq_K562_Human1.82553066
33BCAT_22108803_ChIP-Seq_LS180_Human1.79688523
34NANOG_18555785_Chip-Seq_ESCs_Mouse1.78870951
35NOTCH1_21737748_ChIP-Seq_TLL_Human1.76547211
36TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.75877601
37E2F1_18555785_Chip-Seq_ESCs_Mouse1.75576031
38RUNX1_27457419_Chip-Seq_LIVER_Mouse1.75385888
39ETV2_25802403_ChIP-Seq_MESCs_Mouse1.73543424
40IRF8_27001747_Chip-Seq_BMDM_Mouse1.72699019
41* IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.72031565
42EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.70862290
43CTBP2_25329375_ChIP-Seq_LNCAP_Human1.70722426
44EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.70554621
45ZFX_18555785_Chip-Seq_ESCs_Mouse1.69966687
46SOX2_18555785_Chip-Seq_ESCs_Mouse1.69663440
47P300_18555785_Chip-Seq_ESCs_Mouse1.68961424
48OCT4_18555785_Chip-Seq_ESCs_Mouse1.66217354
49SMAD_19615063_ChIP-ChIP_OVARY_Human1.65440590
50PU1_27457419_Chip-Seq_LIVER_Mouse1.62567926
51STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.61463749
52SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.59363358
53KLF4_18555785_Chip-Seq_ESCs_Mouse1.58466810
54CMYC_18555785_Chip-Seq_ESCs_Mouse1.56907950
55ESRRB_18555785_Chip-Seq_ESCs_Mouse1.55506479
56IRF1_19129219_ChIP-ChIP_H3396_Human1.55145705
57* TP53_22573176_ChIP-Seq_HFKS_Human1.52940101
58GATA3_21878914_ChIP-Seq_MCF-7_Human1.48301899
59CTCF_18555785_Chip-Seq_ESCs_Mouse1.47189596
60SMAD1_18555785_Chip-Seq_ESCs_Mouse1.46965214
61MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.44732024
62SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.40885760
63* PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.39216858
64EGR1_23403033_ChIP-Seq_LIVER_Mouse1.38984873
65P300_19829295_ChIP-Seq_ESCs_Human1.38465929
66FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.37870553
67NANOG_19829295_ChIP-Seq_ESCs_Human1.37279278
68SOX2_19829295_ChIP-Seq_ESCs_Human1.37279278
69* FOXA1_27270436_Chip-Seq_PROSTATE_Human1.37161240
70* FOXA1_25329375_ChIP-Seq_VCAP_Human1.37161240
71CRX_20693478_ChIP-Seq_RETINA_Mouse1.36979951
72TAL1_26923725_Chip-Seq_HPCs_Mouse1.36207394
73KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.36125396
74IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.35793386
75CBP_20019798_ChIP-Seq_JUKART_Human1.35793386
76TP63_19390658_ChIP-ChIP_HaCaT_Human1.35186315
77FOXA1_21572438_ChIP-Seq_LNCaP_Human1.33630516
78TCF4_22108803_ChIP-Seq_LS180_Human1.32777567
79AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.31276692
80AR_20517297_ChIP-Seq_VCAP_Human1.31056221
81TAF15_26573619_Chip-Seq_HEK293_Human1.29660017
82REST_21632747_ChIP-Seq_MESCs_Mouse1.28664770
83MYC_19829295_ChIP-Seq_ESCs_Human1.27985191
84MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.27230071
85PRDM14_20953172_ChIP-Seq_ESCs_Human1.24956433
86POU5F1_16153702_ChIP-ChIP_HESCs_Human1.24328434
87STAT3_23295773_ChIP-Seq_U87_Human1.23557733
88HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.22937565
89EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.22219486
90OCT4_21477851_ChIP-Seq_ESCs_Mouse1.22054273
91RNF2_27304074_Chip-Seq_NSC_Mouse1.21530337
92UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.21386795
93CDX2_22108803_ChIP-Seq_LS180_Human1.20088400
94TCF4_23295773_ChIP-Seq_U87_Human1.20040231
95GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.19246451
96NR3C1_21868756_ChIP-Seq_MCF10A_Human1.19186911
97AUTS2_25519132_ChIP-Seq_293T-REX_Human1.19088600
98* CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.18449830
99GATA3_26560356_Chip-Seq_TH2_Human1.17827755
100SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.17704709
101DROSHA_22980978_ChIP-Seq_HELA_Human1.17680348
102CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.16838015
103GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.16719432
104CBX2_27304074_Chip-Seq_ESCs_Mouse1.16529054
105STAT4_19710469_ChIP-ChIP_TH1__Mouse1.16516647
106BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.16482134
107SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.16429554
108NCOR_22424771_ChIP-Seq_293T_Human1.16407424
109PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.16290117
110STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.15985654
111FOXH1_21741376_ChIP-Seq_ESCs_Human1.13636331
112TAF2_19829295_ChIP-Seq_ESCs_Human1.13078997
113SMAD4_21741376_ChIP-Seq_EPCs_Human1.09408481
114TOP2B_26459242_ChIP-Seq_MCF-7_Human1.09366026
115IKZF1_21737484_ChIP-ChIP_HCT116_Human1.09258097
116FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.08601013
117NANOG_20526341_ChIP-Seq_ESCs_Human1.07353672
118TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07181246
119POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.07181246
120CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.06144979
121CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05515241
122KLF5_20875108_ChIP-Seq_MESCs_Mouse1.05141950
123RUNX_20019798_ChIP-Seq_JUKART_Human1.05101784
124MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.04961449
125EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.04454019
126PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.03928946
127HOXB7_26014856_ChIP-Seq_BT474_Human1.03481843
128SMAD3_21741376_ChIP-Seq_EPCs_Human1.03291955
129ERA_21632823_ChIP-Seq_H3396_Human1.02645992
130LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.02279719
131EWS_26573619_Chip-Seq_HEK293_Human1.02233575
132MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.01688065
133FUS_26573619_Chip-Seq_HEK293_Human1.01526469
134VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.01402739
135SRF_21415370_ChIP-Seq_HL-1_Mouse1.01194608
136FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.00834712
137OCT4_20526341_ChIP-Seq_ESCs_Human1.00280639
138RUNX2_22187159_ChIP-Seq_PCA_Human0.99956663
139* FOXH1_21741376_ChIP-Seq_EPCs_Human0.98884294
140EED_16625203_ChIP-ChIP_MESCs_Mouse0.98209177
141NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.97980082
142MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.97939702
143TP53_18474530_ChIP-ChIP_U2OS_Human0.97628520
144* ETV1_20927104_ChIP-Seq_GIST48_Human0.96992591
145KAP1_22055183_ChIP-Seq_ESCs_Mouse0.96955393
146PIAS1_25552417_ChIP-Seq_VCAP_Human0.96585627
147PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.96535944
148CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.96519183
149SMAD4_21799915_ChIP-Seq_A2780_Human0.96366142
150PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.96167370
151TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.96063275
152Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.95950133
153SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.94711508
154GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.94391070
155PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.93996442
156WT1_19549856_ChIP-ChIP_CCG9911_Human0.93573512
157KDM2B_26808549_Chip-Seq_REH_Human0.93376617
158LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.92001731
159PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.90431023
160SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.87849400
161VDR_22108803_ChIP-Seq_LS180_Human0.87348349
162AR_25329375_ChIP-Seq_VCAP_Human0.87312075
163ER_23166858_ChIP-Seq_MCF-7_Human0.86982481

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001188_hyperpigmentation3.66649311
2MP0001835_abnormal_antigen_presentation3.34927520
3MP0000015_abnormal_ear_pigmentation3.33762805
4MP0002138_abnormal_hepatobiliary_system3.10413385
5MP0006292_abnormal_olfactory_placode3.04790151
6MP0005360_urolithiasis3.00343011
7MP0002876_abnormal_thyroid_physiology2.90040898
8MP0001986_abnormal_taste_sensitivity2.69759312
9MP0001501_abnormal_sleep_pattern2.60640459
10MP0010386_abnormal_urinary_bladder2.60579236
11MP0002148_abnormal_hypersensitivity_rea2.45565447
12MP0002009_preneoplasia2.39204938
13MP0005671_abnormal_response_to2.39037669
14MP0000566_synostosis2.38440456
15MP0005551_abnormal_eye_electrophysiolog2.37605962
16MP0005409_darkened_coat_color2.37412903
17MP0005646_abnormal_pituitary_gland2.36605019
18MP0005645_abnormal_hypothalamus_physiol2.35044167
19MP0008875_abnormal_xenobiotic_pharmacok2.28387945
20MP0001790_abnormal_immune_system2.24411449
21MP0005387_immune_system_phenotype2.24411449
22MP0001873_stomach_inflammation2.22109951
23MP0003763_abnormal_thymus_physiology2.20953569
24MP0004381_abnormal_hair_follicle2.19484693
25MP0008872_abnormal_physiological_respon2.14004394
26MP0005174_abnormal_tail_pigmentation2.11080651
27MP0002277_abnormal_respiratory_mucosa2.10239180
28MP0003136_yellow_coat_color2.03145043
29MP0002139_abnormal_hepatobiliary_system2.01221309
30MP0005379_endocrine/exocrine_gland_phen1.98368775
31MP0009785_altered_susceptibility_to1.96955723
32MP0004782_abnormal_surfactant_physiolog1.93368555
33MP0005365_abnormal_bile_salt1.92354438
34MP0005085_abnormal_gallbladder_physiolo1.92062295
35MP0000372_irregular_coat_pigmentation1.88980413
36MP0003724_increased_susceptibility_to1.87335939
37MP0002638_abnormal_pupillary_reflex1.86336093
38MP0001968_abnormal_touch/_nociception1.84869082
39MP0002653_abnormal_ependyma_morphology1.83820453
40MP0002419_abnormal_innate_immunity1.82865390
41MP0003787_abnormal_imprinting1.81315594
42MP0005000_abnormal_immune_tolerance1.76722487
43MP0002132_abnormal_respiratory_system1.73540916
44MP0005075_abnormal_melanosome_morpholog1.69265107
45MP0004043_abnormal_pH_regulation1.66499200
46MP0002452_abnormal_antigen_presenting1.66244819
47MP0001800_abnormal_humoral_immune1.65626416
48MP0005670_abnormal_white_adipose1.62527957
49MP0005171_absent_coat_pigmentation1.60681486
50MP0005025_abnormal_response_to1.56688806
51MP0000569_abnormal_digit_pigmentation1.53107627
52MP0009333_abnormal_splenocyte_physiolog1.50849089
53MP0001819_abnormal_immune_cell1.48951874
54MP0002420_abnormal_adaptive_immunity1.48848140
55MP0002723_abnormal_immune_serum1.47689731
56MP0001764_abnormal_homeostasis1.47463704
57MP0002095_abnormal_skin_pigmentation1.47359384
58MP0000678_abnormal_parathyroid_gland1.46429973
59MP0001485_abnormal_pinna_reflex1.42269163
60MP0000427_abnormal_hair_cycle1.39298711
61MP0005332_abnormal_amino_acid1.37641147
62MP0009697_abnormal_copulation1.35482470
63MP0003011_delayed_dark_adaptation1.33572440
64MP0003195_calcinosis1.32205158
65MP0005253_abnormal_eye_physiology1.32093924
66MP0001663_abnormal_digestive_system1.29875103
67MP0001666_abnormal_nutrient_absorption1.29630216
68MP0004147_increased_porphyrin_level1.29043210
69MP0004142_abnormal_muscle_tone1.26282765
70MP0005257_abnormal_intraocular_pressure1.25843184
71MP0009745_abnormal_behavioral_response1.25717539
72MP0002272_abnormal_nervous_system1.21814329
73MP0009764_decreased_sensitivity_to1.21730127
74MP0004019_abnormal_vitamin_homeostasis1.20842511
75MP0003646_muscle_fatigue1.20162014
76MP0003436_decreased_susceptibility_to1.17948209
77MP0000681_abnormal_thyroid_gland1.17902877
78MP0002837_dystrophic_cardiac_calcinosis1.16856082
79MP0000230_abnormal_systemic_arterial1.16429787
80MP0004885_abnormal_endolymph1.16378692
81MP0001664_abnormal_digestion1.16034314
82MP0002733_abnormal_thermal_nociception1.14907833
83MP0005058_abnormal_lysosome_morphology1.13823240
84MP0010155_abnormal_intestine_physiology1.13771429
85MP0000631_abnormal_neuroendocrine_gland1.12644347
86MP0006072_abnormal_retinal_apoptosis1.12454647
87MP0002405_respiratory_system_inflammati1.12095872
88MP0001919_abnormal_reproductive_system1.10766268
89MP0008058_abnormal_DNA_repair1.07371115
90MP0005310_abnormal_salivary_gland1.05118974
91MP0001970_abnormal_pain_threshold1.05081273
92MP0001186_pigmentation_phenotype1.04809337
93MP0010329_abnormal_lipoprotein_level1.03855349
94MP0003252_abnormal_bile_duct1.03853196
95MP0002693_abnormal_pancreas_physiology1.01642614
96MP0000716_abnormal_immune_system0.98896152
97MP0003183_abnormal_peptide_metabolism0.98858191
98MP0002006_tumorigenesis0.98724005
99MP0002254_reproductive_system_inflammat0.95131528
100MP0000490_abnormal_crypts_of0.95039235
101MP0001845_abnormal_inflammatory_respons0.94647205
102MP0008260_abnormal_autophagy0.94638640
103MP0005381_digestive/alimentary_phenotyp0.94022830
104MP0001440_abnormal_grooming_behavior0.92306675
105MP0002557_abnormal_social/conspecific_i0.92031617
106MP0009643_abnormal_urine_homeostasis0.92011148
107MP0003806_abnormal_nucleotide_metabolis0.91242951
108MP0002398_abnormal_bone_marrow0.91180808
109MP0000685_abnormal_immune_system0.90141717
110MP0002163_abnormal_gland_morphology0.89837762
111MP0001905_abnormal_dopamine_level0.89676451
112MP0008789_abnormal_olfactory_epithelium0.87169057
113MP0008995_early_reproductive_senescence0.86223250
114MP0003866_abnormal_defecation0.86183346
115MP0002166_altered_tumor_susceptibility0.85721287
116MP0003878_abnormal_ear_physiology0.85694690
117MP0005377_hearing/vestibular/ear_phenot0.85694690
118MP0006276_abnormal_autonomic_nervous0.84129241
119MP0004924_abnormal_behavior0.83901508
120MP0005386_behavior/neurological_phenoty0.83901508
121MP0005389_reproductive_system_phenotype0.83181141
122MP0003941_abnormal_skin_development0.82358273
123MP0002928_abnormal_bile_duct0.80616297
124MP0003300_gastrointestinal_ulcer0.80590395
125MP0001984_abnormal_olfaction0.80374828
126MP0008775_abnormal_heart_ventricle0.80148619
127MP0003283_abnormal_digestive_organ0.79585742
128MP0008007_abnormal_cellular_replicative0.78843766
129MP0002136_abnormal_kidney_physiology0.78303274
130MP0000538_abnormal_urinary_bladder0.77404932
131MP0000689_abnormal_spleen_morphology0.77287473
132MP0000383_abnormal_hair_follicle0.77218450
133MP0002102_abnormal_ear_morphology0.76920244
134MP0002998_abnormal_bone_remodeling0.76469446
135MP0005084_abnormal_gallbladder_morpholo0.75694369
136MP0004510_myositis0.75532433
137MP0002735_abnormal_chemical_nociception0.75515924
138MP0002064_seizures0.75266284
139MP0005195_abnormal_posterior_eye0.74962366
140MP0002429_abnormal_blood_cell0.74269249
141MP0000343_altered_response_to0.72868384
142MP0003315_abnormal_perineum_morphology0.71491690
143MP0002177_abnormal_outer_ear0.71001309
144MP0005464_abnormal_platelet_physiology0.70544875
145MP0000026_abnormal_inner_ear0.69659768
146MP0000371_diluted_coat_color0.69599355
147MP0004264_abnormal_extraembryonic_tissu0.68802835
148MP0002933_joint_inflammation0.67561764
149MP0003828_pulmonary_edema0.66769445
150MP0002098_abnormal_vibrissa_morphology0.66413295
151MP0005367_renal/urinary_system_phenotyp0.65774079
152MP0000516_abnormal_urinary_system0.65774079
153MP0004742_abnormal_vestibular_system0.65370294
154MP0002751_abnormal_autonomic_nervous0.64488168
155MP0001502_abnormal_circadian_rhythm0.63927001
156MP0008877_abnormal_DNA_methylation0.63629596
157MP0003045_fibrosis0.62720233
158MP0002736_abnormal_nociception_after0.62568169

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)4.36491017
2Congenital stationary night blindness (HP:0007642)4.24595321
3Chromsome breakage (HP:0040012)3.74963955
4Abnormality of midbrain morphology (HP:0002418)3.65821286
5Molar tooth sign on MRI (HP:0002419)3.65821286
6Vacuolated lymphocytes (HP:0001922)3.56287091
7Type I transferrin isoform profile (HP:0003642)3.37452511
8True hermaphroditism (HP:0010459)3.31305376
9Hyperventilation (HP:0002883)3.23048458
10Recurrent abscess formation (HP:0002722)3.14966733
11Abnormality of glutamine family amino acid metabolism (HP:0010902)3.13147879
12Abolished electroretinogram (ERG) (HP:0000550)3.07418597
13Abnormality of the renal cortex (HP:0011035)3.06376880
14Tubular atrophy (HP:0000092)3.05694099
15Nephronophthisis (HP:0000090)3.04348792
16Chronic diarrhea (HP:0002028)2.96939368
17Hypothermia (HP:0002045)2.88566842
18Eczematoid dermatitis (HP:0000976)2.82891338
19Hypoplasia of the fovea (HP:0007750)2.80797898
20Aplasia/Hypoplasia of the fovea (HP:0008060)2.80797898
21Duplicated collecting system (HP:0000081)2.78244600
22Prostate neoplasm (HP:0100787)2.76809896
23Panhypogammaglobulinemia (HP:0003139)2.72056768
24Recurrent bacterial skin infections (HP:0005406)2.69789948
25Abnormality of the renal medulla (HP:0100957)2.64763108
26Abnormality of homocysteine metabolism (HP:0010919)2.61398441
27Homocystinuria (HP:0002156)2.61398441
28Abnormality of vitamin B metabolism (HP:0004340)2.59565829
29Metabolic alkalosis (HP:0200114)2.58311276
30Abnormality of the renal collecting system (HP:0004742)2.58200268
31Agammaglobulinemia (HP:0004432)2.54318701
32Abnormality of the vitamin B12 metabolism (HP:0004341)2.53643260
33White forelock (HP:0002211)2.53455304
34Optic neuritis (HP:0100653)2.52802192
35Retrobulbar optic neuritis (HP:0100654)2.52802192
36Attenuation of retinal blood vessels (HP:0007843)2.52699623
37Petechiae (HP:0000967)2.50548272
38Abnormal delayed hypersensitivity skin test (HP:0002963)2.48808118
39Osteomalacia (HP:0002749)2.48411199
40Decreased electroretinogram (ERG) amplitude (HP:0000654)2.47112941
41Pancreatic fibrosis (HP:0100732)2.45658452
42Malnutrition (HP:0004395)2.44769885
43Polydipsia (HP:0001959)2.44749946
44Abnormal drinking behavior (HP:0030082)2.44749946
45Renal cortical cysts (HP:0000803)2.44535417
46Abnormality of the preputium (HP:0100587)2.41368300
47Alkalosis (HP:0001948)2.40048516
48Submucous cleft hard palate (HP:0000176)2.37815707
49Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.37367395
50Abnormal protein N-linked glycosylation (HP:0012347)2.37367395
51Abnormal protein glycosylation (HP:0012346)2.37367395
52Abnormal glycosylation (HP:0012345)2.37367395
53Patchy hypopigmentation of hair (HP:0011365)2.37154024
54Recurrent pneumonia (HP:0006532)2.36969384
55Systemic lupus erythematosus (HP:0002725)2.36812520
56Decreased circulating renin level (HP:0003351)2.36415910
57Abnormal biliary tract physiology (HP:0012439)2.35674915
58Bile duct proliferation (HP:0001408)2.35674915
59Pendular nystagmus (HP:0012043)2.33711532
60Chronic mucocutaneous candidiasis (HP:0002728)2.33153084
61Recurrent cutaneous fungal infections (HP:0011370)2.33153084
62Reduced antithrombin III activity (HP:0001976)2.32031821
63Abnormality of the fovea (HP:0000493)2.30987987
64Clubbing of toes (HP:0100760)2.29725957
65Aplasia/Hypoplasia of the uvula (HP:0010293)2.29635832
66Abnormality of renin-angiotensin system (HP:0000847)2.25010850
67Abnormality of proline metabolism (HP:0010907)2.24769993
68Hydroxyprolinuria (HP:0003080)2.24769993
69Hypoproteinemia (HP:0003075)2.24585191
70Abnormal rod and cone electroretinograms (HP:0008323)2.24186708
71Abnormality of the prostate (HP:0008775)2.23790731
72Keratoconus (HP:0000563)2.22936651
73Increased corneal curvature (HP:0100692)2.22936651
74Mediastinal lymphadenopathy (HP:0100721)2.22691085
75Pancreatic cysts (HP:0001737)2.21786622
763-Methylglutaconic aciduria (HP:0003535)2.21475008
77Stomach cancer (HP:0012126)2.19847474
78Polyuria (HP:0000103)2.17162373
79Obstructive lung disease (HP:0006536)2.16753321
80Chronic obstructive pulmonary disease (HP:0006510)2.16753321
81Chorioretinal atrophy (HP:0000533)2.15579840
82Recurrent fungal infections (HP:0002841)2.13887937
83Abnormality of mucopolysaccharide metabolism (HP:0011020)2.12319421
84Abnormality of polysaccharide metabolism (HP:0011012)2.12319421
85Abnormality of glycosaminoglycan metabolism (HP:0004371)2.12319421
86Ectopic kidney (HP:0000086)2.12275872
87Absent rod-and cone-mediated responses on ERG (HP:0007688)2.11217840
88Abnormal hair whorl (HP:0010721)2.11181064
89Meningitis (HP:0001287)2.10839458
90Abnormality of urine glucose concentration (HP:0011016)2.09966792
91Glycosuria (HP:0003076)2.09966792
92Abnormal albumin level (HP:0012116)2.08373607
93Hypoalbuminemia (HP:0003073)2.08373607
94Limb dystonia (HP:0002451)2.08338615
95Inability to walk (HP:0002540)2.08326749
96Decreased central vision (HP:0007663)2.05752658
97Pigmentary retinal degeneration (HP:0001146)2.05666182
98Gingivitis (HP:0000230)2.05403248
99Dysostosis multiplex (HP:0000943)2.05203699
100Stomatitis (HP:0010280)2.03395595
101Concave nail (HP:0001598)2.03102268
102Chronic otitis media (HP:0000389)2.02229669
103Urinary glycosaminoglycan excretion (HP:0003541)2.00921128
104Mucopolysacchariduria (HP:0008155)2.00921128
105Abnormality of renal resorption (HP:0011038)2.00523336
106Myositis (HP:0100614)2.00265122
107Polyphagia (HP:0002591)2.00073412
108Gait imbalance (HP:0002141)2.00003825
109Abnormality of calcium-phosphate metabolism (HP:0100530)1.99961494
110Progressive inability to walk (HP:0002505)1.98329847
111Orchitis (HP:0100796)1.97795410
112Abnormal urine output (HP:0012590)1.96592181
113Elevated erythrocyte sedimentation rate (HP:0003565)1.96125237
114Renal tubular acidosis (HP:0001947)1.94657727
115Congenital hepatic fibrosis (HP:0002612)1.93600584
116Hyperglycinuria (HP:0003108)1.93126916
117Abnormal ciliary motility (HP:0012262)1.93062528
118Methylmalonic aciduria (HP:0012120)1.92929383
119Abnormality of B cell number (HP:0010975)1.92252213
120B lymphocytopenia (HP:0010976)1.92252213
121Nephrogenic diabetes insipidus (HP:0009806)1.91345519
122Conical tooth (HP:0000698)1.91177157
123Abnormality of the right ventricle (HP:0001707)1.91102710
124Meckel diverticulum (HP:0002245)1.91036532
125Abnormality of glycine metabolism (HP:0010895)1.90609242
126Abnormality of serine family amino acid metabolism (HP:0010894)1.90609242
127Recurrent lower respiratory tract infections (HP:0002783)1.90121871
128Cheilitis (HP:0100825)1.89917242
129Alveolar cell carcinoma (HP:0006519)1.89908129
130Male pseudohermaphroditism (HP:0000037)1.89182135
131IgG deficiency (HP:0004315)1.88844673
132Intestinal atresia (HP:0011100)1.87529107
133Abnormality of chromosome stability (HP:0003220)1.87344044
134Abnormality of macular pigmentation (HP:0008002)1.87133368
135Congenital primary aphakia (HP:0007707)1.87110997
136Abnormality of T cell physiology (HP:0011840)1.86709770
137Prolonged neonatal jaundice (HP:0006579)1.85683027
138Abnormality of DNA repair (HP:0003254)1.85355421
139Renal Fanconi syndrome (HP:0001994)1.83236695
140Absent/shortened dynein arms (HP:0200106)1.81064146
141Dynein arm defect of respiratory motile cilia (HP:0012255)1.81064146
142Abnormality of renal excretion (HP:0011036)1.80999970
143Hypoplasia of the thymus (HP:0000778)1.80794098
144Chronic sinusitis (HP:0011109)1.80746343
145Furrowed tongue (HP:0000221)1.80434598
146Glomerulonephritis (HP:0000099)1.80309322
147Medial flaring of the eyebrow (HP:0010747)1.79711946
148Type II lissencephaly (HP:0007260)1.79004045
149Hypomagnesemia (HP:0002917)1.78602622
150Amelogenesis imperfecta (HP:0000705)1.78418491
151Thyroiditis (HP:0100646)1.78089258
152Abnormality of the ileum (HP:0001549)1.77975786
153Chronic hepatic failure (HP:0100626)1.76841275
154Distal lower limb muscle weakness (HP:0009053)1.76821543
155Encephalitis (HP:0002383)1.76634767
156Recurrent skin infections (HP:0001581)1.76464055
157Abnormality of male internal genitalia (HP:0000022)1.76191037
158Sclerocornea (HP:0000647)1.76058060
159Aortic valve stenosis (HP:0001650)1.75894306
160Abnormality of dental color (HP:0011073)1.75822677
161Abnormality of dicarboxylic acid metabolism (HP:0010995)1.75043257
162Dicarboxylic aciduria (HP:0003215)1.75043257
163Mitochondrial inheritance (HP:0001427)1.74984786
164Abnormality of eosinophils (HP:0001879)1.73929370
165Hypergonadotropic hypogonadism (HP:0000815)1.73742629
166Abnormal sex determination (HP:0012244)1.73234108
167Sex reversal (HP:0012245)1.73234108
168Ketosis (HP:0001946)1.73128821
169Congenital sensorineural hearing impairment (HP:0008527)1.72951420
170Conjugated hyperbilirubinemia (HP:0002908)1.72868093
171Large for gestational age (HP:0001520)1.72862477
172Severe combined immunodeficiency (HP:0004430)1.72283449
173Cystic liver disease (HP:0006706)1.71959867
174Prolonged bleeding time (HP:0003010)1.71589188
175Hemoptysis (HP:0002105)1.71383049
176Recurrent viral infections (HP:0004429)1.70840848
177Renal tubular dysfunction (HP:0000124)1.69191680

Predicted kinase interactions (KEA)

RankGene SetZ-score
1IRAK33.92225534
2MAP4K23.64852339
3IRAK43.22758687
4ZAK3.19134630
5ACVR1B3.14900886
6SIK32.74093222
7INSRR2.73098352
8STK162.68823486
9MAP3K142.59375789
10TXK2.48945556
11CASK2.35875001
12NUAK12.31892834
13WNK32.29988245
14TEC2.20206329
15BMPR1B2.09110662
16STK392.03923373
17OXSR12.00624660
18WNK41.98125571
19PRPF4B1.91072061
20YES11.89303411
21BMPR21.83496617
22PINK11.71568160
23TNK21.70417817
24ADRBK21.68680837
25NLK1.62420823
26CLK11.62276535
27IRAK11.51517194
28DAPK21.49753864
29MST41.44960278
30TNIK1.44844802
31IKBKE1.44547045
32AKT31.40828371
33STK38L1.39108142
34EIF2AK21.39083881
35NEK61.38024131
36TGFBR11.36222667
37EPHA31.36213128
38GRK71.34314238
39BLK1.32335379
40MAP2K71.23811391
41TGFBR21.23008987
42TRPM71.19756922
43MKNK21.11244905
44BTK1.07805740
45GRK11.07587064
46VRK11.06621663
47ADRBK11.05943068
48PAK31.04872731
49CDK31.03811234
50SGK21.02947768
51IKBKB1.02881759
52ERBB31.02219986
53JAK10.99830896
54HIPK20.99148229
55IRAK20.97341736
56TRIM280.96362715
57MAP3K40.96318013
58SRPK10.96009194
59JAK30.93069125
60CDK80.92122888
61MAPK130.87080605
62PLK40.84841091
63CSF1R0.84681476
64CAMKK20.83872819
65FER0.83301219
66FES0.82760916
67MAPK150.81196901
68TYK20.80531497
69MARK10.80206745
70TAOK30.79218700
71CHUK0.78200726
72KIT0.76462882
73FRK0.76195364
74SYK0.74194167
75LYN0.73931349
76CSK0.72527093
77FGFR20.71482759
78DYRK20.70986858
79PIK3CG0.69641476
80PRKCG0.69208836
81PDK20.68397837
82TAOK20.67915275
83ZAP700.66641575
84CCNB10.66131259
85CAMK2A0.65023299
86PLK20.63833706
87MKNK10.58322852
88PRKCZ0.57106070
89TLK10.56802724
90BCR0.56556792
91TBK10.54954279
92RPS6KA50.54685428
93PRKACA0.54250292
94EPHB10.54018672
95PRKCA0.53738848
96PRKCE0.53555755
97TIE10.53142865
98PRKCQ0.52519769
99MAP2K20.52415767
100BRD40.51625997
101SGK2230.51271434
102SGK4940.51271434
103ITK0.50793642
104NME10.50662852
105FGFR30.50345929
106CSNK1A10.49749862
107EIF2AK30.49567352
108PHKG10.49514041
109PHKG20.49514041
110RPS6KB10.49338672
111LCK0.47741838
112MAP4K10.46722716
113EPHB20.46223040
114GRK60.46210435
115NTRK20.46017616
116MAP2K60.45493776
117DYRK1A0.45224879
118MYLK0.43727142
119PIK3CA0.43658713
120CAMK2D0.42890193
121CSNK1G20.42884141
122FGR0.42667636
123PASK0.42440059
124PRKG20.42376952
125CSNK1G30.42060039
126ABL10.41218003
127HCK0.41150871
128PLK30.40844602
129PRKCI0.38914933
130STK240.38804522
131STK110.38591544
132PTK2B0.38124048
133MATK0.37712359
134PRKCD0.36617571
135EIF2AK10.35796941
136SGK30.35787342
137TSSK60.35696875
138BRAF0.35580812
139CSNK1G10.35253022
140IGF1R0.34987230
141MAPK70.33943252
142NEK90.33919072
143MUSK0.33188663
144PKN10.32254838
145RPS6KA60.32200119
146KDR0.30706876
147PRKACG0.30443630

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030602.91391552
2Other glycan degradation_Homo sapiens_hsa005112.77699056
3Glycosaminoglycan degradation_Homo sapiens_hsa005312.75650164
4Cyanoamino acid metabolism_Homo sapiens_hsa004602.69786407
5Caffeine metabolism_Homo sapiens_hsa002322.57756231
6NF-kappa B signaling pathway_Homo sapiens_hsa040642.40726318
7Intestinal immune network for IgA production_Homo sapiens_hsa046722.31678135
8Primary immunodeficiency_Homo sapiens_hsa053402.29647827
9Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.24720612
10Maturity onset diabetes of the young_Homo sapiens_hsa049502.13020960
11Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.96938336
12Nitrogen metabolism_Homo sapiens_hsa009101.89965450
13* Fat digestion and absorption_Homo sapiens_hsa049751.88891330
14Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.85720389
15Autoimmune thyroid disease_Homo sapiens_hsa053201.85692646
16Fanconi anemia pathway_Homo sapiens_hsa034601.74492146
17Sulfur metabolism_Homo sapiens_hsa009201.69896205
18Graft-versus-host disease_Homo sapiens_hsa053321.68288517
19* Arachidonic acid metabolism_Homo sapiens_hsa005901.63922762
20Hematopoietic cell lineage_Homo sapiens_hsa046401.63100759
21Measles_Homo sapiens_hsa051621.61178070
22Tryptophan metabolism_Homo sapiens_hsa003801.60025040
23Homologous recombination_Homo sapiens_hsa034401.58286801
24Allograft rejection_Homo sapiens_hsa053301.57933832
25Leishmaniasis_Homo sapiens_hsa051401.54156975
26Toll-like receptor signaling pathway_Homo sapiens_hsa046201.52146931
27RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.50080125
28Butanoate metabolism_Homo sapiens_hsa006501.49806641
29SNARE interactions in vesicular transport_Homo sapiens_hsa041301.49301792
30Sphingolipid metabolism_Homo sapiens_hsa006001.49232629
31Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.48801829
32Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.45031612
33Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.42750378
34Lysosome_Homo sapiens_hsa041421.40493968
35Selenocompound metabolism_Homo sapiens_hsa004501.39158767
36RNA polymerase_Homo sapiens_hsa030201.36702956
37Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.32926375
38Non-homologous end-joining_Homo sapiens_hsa034501.31287587
39Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.28133263
40Chemical carcinogenesis_Homo sapiens_hsa052041.27967784
41Rheumatoid arthritis_Homo sapiens_hsa053231.25967837
42Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.23229598
43Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.20438661
44Staphylococcus aureus infection_Homo sapiens_hsa051501.16572810
45Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.16339247
46Herpes simplex infection_Homo sapiens_hsa051681.15576748
47Antigen processing and presentation_Homo sapiens_hsa046121.15024600
48NOD-like receptor signaling pathway_Homo sapiens_hsa046211.10593397
49Legionellosis_Homo sapiens_hsa051341.09405057
50Pertussis_Homo sapiens_hsa051331.09275344
51Type I diabetes mellitus_Homo sapiens_hsa049401.07795684
52Histidine metabolism_Homo sapiens_hsa003401.05455804
53Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.04534889
54Base excision repair_Homo sapiens_hsa034101.03472559
55African trypanosomiasis_Homo sapiens_hsa051430.99095100
56Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.98937177
57Steroid hormone biosynthesis_Homo sapiens_hsa001400.98862541
58Pentose and glucuronate interconversions_Homo sapiens_hsa000400.98524080
59Pyrimidine metabolism_Homo sapiens_hsa002400.97815198
60Malaria_Homo sapiens_hsa051440.97338454
61Glycerolipid metabolism_Homo sapiens_hsa005610.95416714
62Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.94285997
63Tuberculosis_Homo sapiens_hsa051520.92180278
64Osteoclast differentiation_Homo sapiens_hsa043800.91764261
65Primary bile acid biosynthesis_Homo sapiens_hsa001200.90340309
66Peroxisome_Homo sapiens_hsa041460.88633800
67TNF signaling pathway_Homo sapiens_hsa046680.85886391
68Phagosome_Homo sapiens_hsa041450.85604722
69Basal transcription factors_Homo sapiens_hsa030220.85392710
70Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.84408261
71Parkinsons disease_Homo sapiens_hsa050120.84334331
72Jak-STAT signaling pathway_Homo sapiens_hsa046300.83369172
73Regulation of autophagy_Homo sapiens_hsa041400.83114872
74* Ether lipid metabolism_Homo sapiens_hsa005650.82670793
75Asthma_Homo sapiens_hsa053100.82648337
76Taste transduction_Homo sapiens_hsa047420.82565759
77Chemokine signaling pathway_Homo sapiens_hsa040620.81979446
78Transcriptional misregulation in cancer_Homo sapiens_hsa052020.80879229
79Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.80803250
80Viral myocarditis_Homo sapiens_hsa054160.80662175
81Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.79009815
82Influenza A_Homo sapiens_hsa051640.78295998
83Purine metabolism_Homo sapiens_hsa002300.77968886
84RNA degradation_Homo sapiens_hsa030180.75581894
85Renin-angiotensin system_Homo sapiens_hsa046140.75269260
86Phototransduction_Homo sapiens_hsa047440.74135415
87Fatty acid degradation_Homo sapiens_hsa000710.69462171
88Mismatch repair_Homo sapiens_hsa034300.67964624
89Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.67841152
90Ovarian steroidogenesis_Homo sapiens_hsa049130.66259971
91T cell receptor signaling pathway_Homo sapiens_hsa046600.65089540
92Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.63584479
93Propanoate metabolism_Homo sapiens_hsa006400.63263727
94Olfactory transduction_Homo sapiens_hsa047400.62894659
95N-Glycan biosynthesis_Homo sapiens_hsa005100.62766176
96Arginine biosynthesis_Homo sapiens_hsa002200.61617975
97Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.61526910
98B cell receptor signaling pathway_Homo sapiens_hsa046620.59473308
99* alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.59081773
100Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.58912510
101* Linoleic acid metabolism_Homo sapiens_hsa005910.58379305
102Toxoplasmosis_Homo sapiens_hsa051450.58243953
103Sulfur relay system_Homo sapiens_hsa041220.57135644
104Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.56696069
105Carbohydrate digestion and absorption_Homo sapiens_hsa049730.56455278
106Apoptosis_Homo sapiens_hsa042100.55628709
107* Glycerophospholipid metabolism_Homo sapiens_hsa005640.55200062
108Arginine and proline metabolism_Homo sapiens_hsa003300.53102018
109Galactose metabolism_Homo sapiens_hsa000520.50401926
110Hepatitis C_Homo sapiens_hsa051600.48642236
111Protein digestion and absorption_Homo sapiens_hsa049740.47178609
112Serotonergic synapse_Homo sapiens_hsa047260.46764350
113Drug metabolism - other enzymes_Homo sapiens_hsa009830.46574755
114DNA replication_Homo sapiens_hsa030300.46536222
115Salmonella infection_Homo sapiens_hsa051320.46450657
116Insulin secretion_Homo sapiens_hsa049110.46406697
117Hepatitis B_Homo sapiens_hsa051610.46340686
118Salivary secretion_Homo sapiens_hsa049700.45421134
119ABC transporters_Homo sapiens_hsa020100.44878803
120Notch signaling pathway_Homo sapiens_hsa043300.44820119
121Nicotine addiction_Homo sapiens_hsa050330.44527042
122Dorso-ventral axis formation_Homo sapiens_hsa043200.43132233
123Cardiac muscle contraction_Homo sapiens_hsa042600.41574603
124Vibrio cholerae infection_Homo sapiens_hsa051100.40840189
125Morphine addiction_Homo sapiens_hsa050320.40681521
126Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.40563719
127Epstein-Barr virus infection_Homo sapiens_hsa051690.40553554
128p53 signaling pathway_Homo sapiens_hsa041150.40040878
129Circadian rhythm_Homo sapiens_hsa047100.40017585
130Mineral absorption_Homo sapiens_hsa049780.38822129
131Glutathione metabolism_Homo sapiens_hsa004800.38788445
132Nucleotide excision repair_Homo sapiens_hsa034200.38065606
133Systemic lupus erythematosus_Homo sapiens_hsa053220.37646100
134Alzheimers disease_Homo sapiens_hsa050100.37288410
135Collecting duct acid secretion_Homo sapiens_hsa049660.37226691
136Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.37168736
137Retinol metabolism_Homo sapiens_hsa008300.36249636
138* Metabolic pathways_Homo sapiens_hsa011000.36133329
139* Vascular smooth muscle contraction_Homo sapiens_hsa042700.35394382
140Vitamin digestion and absorption_Homo sapiens_hsa049770.35270625
141Cocaine addiction_Homo sapiens_hsa050300.35236346
142Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.34268729
143Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.33450874
144Oxidative phosphorylation_Homo sapiens_hsa001900.31962477
145* Pancreatic secretion_Homo sapiens_hsa049720.31960229
146Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.31729256
147Proteasome_Homo sapiens_hsa030500.30167612
148Long-term depression_Homo sapiens_hsa047300.29997892
149One carbon pool by folate_Homo sapiens_hsa006700.28819786
150Starch and sucrose metabolism_Homo sapiens_hsa005000.27830751
151Huntingtons disease_Homo sapiens_hsa050160.27417410
152PPAR signaling pathway_Homo sapiens_hsa033200.27377765

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