PLA2G2E

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1keratinization (GO:0031424)9.35989104
2citrulline biosynthetic process (GO:0019240)9.27225056
3melanin biosynthetic process (GO:0042438)8.17445556
4melanin metabolic process (GO:0006582)7.22014681
5adhesion of symbiont to host cell (GO:0044650)6.82981007
6virion attachment to host cell (GO:0019062)6.82981007
7secondary metabolite biosynthetic process (GO:0044550)6.64438111
8intermediate filament organization (GO:0045109)6.34738640
9citrulline metabolic process (GO:0000052)5.99551323
10adhesion of symbiont to host (GO:0044406)5.94824661
11keratinocyte differentiation (GO:0030216)5.51723395
12desmosome organization (GO:0002934)5.24149168
13hemidesmosome assembly (GO:0031581)5.03745542
14peptidyl-arginine modification (GO:0018195)4.92520686
15epidermis development (GO:0008544)4.90927066
16peptide cross-linking (GO:0018149)4.76753590
17hair follicle morphogenesis (GO:0031069)4.71730825
18low-density lipoprotein particle clearance (GO:0034383)4.57283399
19skin morphogenesis (GO:0043589)4.39121622
20epidermal cell differentiation (GO:0009913)4.14615337
21positive regulation of osteoblast proliferation (GO:0033690)4.08684391
22wound healing, spreading of epidermal cells (GO:0035313)4.03873994
23negative regulation of complement activation (GO:0045916)3.56560400
24positive regulation of p38MAPK cascade (GO:1900745)3.42995626
25positive regulation of hair cycle (GO:0042635)3.38880883
26positive regulation of hair follicle development (GO:0051798)3.38880883
27intermediate filament cytoskeleton organization (GO:0045104)3.34694651
28pentose-phosphate shunt (GO:0006098)3.22210243
29intermediate filament-based process (GO:0045103)3.21925160
30tyrosine metabolic process (GO:0006570)3.11882654
31negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.00969799
32maintenance of gastrointestinal epithelium (GO:0030277)3.00556382
33wound healing, spreading of cells (GO:0044319)3.00432634
34interferon-gamma secretion (GO:0072643)2.97067046
35response to host immune response (GO:0052572)2.97027286
36response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.97027286
37hair cycle process (GO:0022405)2.94613069
38molting cycle process (GO:0022404)2.94613069
39branching involved in salivary gland morphogenesis (GO:0060445)2.92812626
40NADPH regeneration (GO:0006740)2.91357657
41positive regulation by symbiont of host defense response (GO:0052509)2.90574304
42modulation by symbiont of host defense response (GO:0052031)2.90574304
43modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.90574304
44modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.90574304
45positive regulation by organism of defense response of other organism involved in symbiotic interact2.90574304
46modulation by symbiont of host immune response (GO:0052553)2.90574304
47regulation of water loss via skin (GO:0033561)2.89569984
48decidualization (GO:0046697)2.88885816
49regulation of hair follicle development (GO:0051797)2.88862791
50tooth mineralization (GO:0034505)2.85465314
51cell-substrate junction assembly (GO:0007044)2.84122980
52developmental pigmentation (GO:0048066)2.80028093
53negative regulation of protein activation cascade (GO:2000258)2.79596908
54lung lobe morphogenesis (GO:0060463)2.77750781
55regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.76590660
56regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.73411747
57myotube differentiation (GO:0014902)2.71951942
58regulation of mononuclear cell migration (GO:0071675)2.71730420
59peptidyl-proline hydroxylation (GO:0019511)2.70457541
60apoptotic cell clearance (GO:0043277)2.69656905
61cell wall macromolecule metabolic process (GO:0044036)2.68768007
62cell wall macromolecule catabolic process (GO:0016998)2.68768007
63regulation of apoptotic cell clearance (GO:2000425)2.66801814
64response to host (GO:0075136)2.66662295
65response to host defenses (GO:0052200)2.66662295
66response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.66662295
67cellular hyperosmotic response (GO:0071474)2.65121967
68negative regulation of cell fate specification (GO:0009996)2.64092350
69regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.62998722
704-hydroxyproline metabolic process (GO:0019471)2.61220229
71establishment of skin barrier (GO:0061436)2.59089293
72barbed-end actin filament capping (GO:0051016)2.57760379
73epithelial cell-cell adhesion (GO:0090136)2.54419945
74regulation of complement activation (GO:0030449)2.53258779
75macrophage activation involved in immune response (GO:0002281)2.51997720
76regulation of early endosome to late endosome transport (GO:2000641)2.51933505
77protein heterotrimerization (GO:0070208)2.48493454
78bundle of His cell to Purkinje myocyte communication (GO:0086069)2.47360876
79negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.47203597
80basement membrane organization (GO:0071711)2.46655595
81keratan sulfate catabolic process (GO:0042340)2.46391115
82regulation of epithelial cell differentiation involved in kidney development (GO:2000696)2.46131369
83regulation of cholesterol storage (GO:0010885)2.46130333
84muscle organ morphogenesis (GO:0048644)2.45669346
85regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.44759901
86endodermal cell differentiation (GO:0035987)2.44702373
87cell adhesion mediated by integrin (GO:0033627)2.44283308
88regulation of nephron tubule epithelial cell differentiation (GO:0072182)2.42138711
89apoptotic process involved in morphogenesis (GO:0060561)2.41491433
90lung vasculature development (GO:0060426)2.41136052
91regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)2.40431933
92positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)2.40431933
93epithelial structure maintenance (GO:0010669)2.39555134
94secondary metabolic process (GO:0019748)2.37166654
95antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.31179050
96antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.31179050
97positive regulation of toll-like receptor signaling pathway (GO:0034123)2.31178179
98cytoskeletal anchoring at plasma membrane (GO:0007016)2.30810740
99hair cycle (GO:0042633)19.5972998
100molting cycle (GO:0042303)19.5972998

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human9.37386534
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.98165080
3TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.93199976
4RARG_19884340_ChIP-ChIP_MEFs_Mouse3.22165935
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.17145575
6NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.72261780
7TRIM28_21343339_ChIP-Seq_HEK293_Human2.67301331
8HIF1A_21447827_ChIP-Seq_MCF-7_Human2.39752599
9CLOCK_20551151_ChIP-Seq_293T_Human2.32306686
10* P63_26484246_Chip-Seq_KERATINOCYTES_Human2.32192634
11CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.27949602
12EGR1_19374776_ChIP-ChIP_THP-1_Human2.22785691
13TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.08984333
14ESR1_21235772_ChIP-Seq_MCF-7_Human2.07591360
15SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.04144429
16RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.02765163
17ELK3_25401928_ChIP-Seq_HUVEC_Human1.90237585
18PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.88327431
19RACK7_27058665_Chip-Seq_MCF-7_Human1.87407776
20* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.86318692
21* ATF3_27146783_Chip-Seq_COLON_Human1.84233208
22NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.75624905
23ESR1_15608294_ChIP-ChIP_MCF-7_Human1.75472859
24LXR_22292898_ChIP-Seq_THP-1_Human1.74350226
25* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.71518221
26* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.71518221
27RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.71350765
28ESR2_21235772_ChIP-Seq_MCF-7_Human1.67176805
29FOXO3_23340844_ChIP-Seq_DLD1_Human1.64585225
30SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.55473790
31UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.55282132
32* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.55215168
33IRF8_22096565_ChIP-ChIP_GC-B_Human1.53290895
34CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.52814639
35EGR1_19032775_ChIP-ChIP_M12_Human1.50891661
36* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.47526182
37TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.47418712
38JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.45307778
39IRF8_21731497_ChIP-ChIP_J774_Mouse1.43619846
40SOX2_20726797_ChIP-Seq_SW620_Human1.41001973
41ZNF263_19887448_ChIP-Seq_K562_Human1.40156178
42UBF1/2_26484160_Chip-Seq_HMECs_Human1.37402360
43HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.36925459
44NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.36366519
45CTCF_20526341_ChIP-Seq_ESCs_Human1.34518337
46* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.34281558
47BRD4_27068464_Chip-Seq_AML-cells_Mouse1.31817830
48CDX2_19796622_ChIP-Seq_MESCs_Mouse1.28729939
49* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.25397643
50MYB_21317192_ChIP-Seq_ERMYB_Mouse1.24578168
51JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.24202551
52Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.22725175
53SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.21122375
54SOX9_24532713_ChIP-Seq_HFSC_Mouse1.20475748
55VDR_21846776_ChIP-Seq_THP-1_Human1.20243352
56* CSB_26484114_Chip-Seq_FIBROBLAST_Human1.19715467
57BCL6_27268052_Chip-Seq_Bcells_Human1.19421683
58BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.18961976
59* IRF8_27001747_Chip-Seq_BMDM_Mouse1.18475190
60PPAR_26484153_Chip-Seq_NCI-H1993_Human1.18221917
61KDM2B_26808549_Chip-Seq_SUP-B15_Human1.16584467
62DNAJC2_21179169_ChIP-ChIP_NT2_Human1.15522073
63GATA4_25053715_ChIP-Seq_YYC3_Human1.12846251
64TFEB_21752829_ChIP-Seq_HELA_Human1.12245629
65GATA3_24758297_ChIP-Seq_MCF-7_Human1.11891800
66KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.10954205
67THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.10733428
68TP63_22573176_ChIP-Seq_HFKS_Human1.02344358
69GATA6_25053715_ChIP-Seq_YYC3_Human1.02330230
70STAT3_1855785_ChIP-Seq_MESCs_Mouse1.02004884
71E2F1_20622854_ChIP-Seq_HELA_Human1.01989697
72TAF2_19829295_ChIP-Seq_ESCs_Human0.99312389
73BCOR_27268052_Chip-Seq_Bcells_Human0.98795440
74* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.98778238
75POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.97420568
76KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.96266067
77TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.96159059
78KDM2B_26808549_Chip-Seq_DND41_Human0.95686068
79CJUN_26792858_Chip-Seq_BT549_Human0.95446558
80TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.95251849
81STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.93255866
82TP53_20018659_ChIP-ChIP_R1E_Mouse0.92482449
83RUNX1_27514584_Chip-Seq_MCF-7_Human0.92303606
84ZFP281_18757296_ChIP-ChIP_E14_Mouse0.91774867
85KLF5_25053715_ChIP-Seq_YYC3_Human0.90911310
86ELF1_20517297_ChIP-Seq_JURKAT_Human0.88860920
87SMC4_20622854_ChIP-Seq_HELA_Human0.87905518
88IKZF1_21737484_ChIP-ChIP_HCT116_Human0.87624909
89SMC1_22415368_ChIP-Seq_MEFs_Mouse0.84755255
90SOX2_27498859_Chip-Seq_STOMACH_Mouse0.84301766
91PPARA_22158963_ChIP-Seq_LIVER_Mouse0.83924918
92GATA2_21666600_ChIP-Seq_HMVEC_Human0.83288444
93ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.83239964
94VDR_24763502_ChIP-Seq_THP-1_Human0.82798212
95SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.82087160
96SA1_27219007_Chip-Seq_ERYTHROID_Human0.81626519
97ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.81580748
98TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.80504035
99ERG_20517297_ChIP-Seq_VCAP_Human0.80141735
100TBX20_22328084_ChIP-Seq_HEART_Mouse0.79208482

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle4.95519300
2MP0003705_abnormal_hypodermis_morpholog4.67590081
3MP0005275_abnormal_skin_tensile4.28037239
4MP0000372_irregular_coat_pigmentation4.07800945
5MP0008438_abnormal_cutaneous_collagen4.00937886
6MP0002098_abnormal_vibrissa_morphology4.00019292
7MP0002796_impaired_skin_barrier3.53423707
8MP0000647_abnormal_sebaceous_gland3.42924299
9MP0005171_absent_coat_pigmentation3.32834352
10MP0000579_abnormal_nail_morphology3.24536581
11MP0010678_abnormal_skin_adnexa2.53166536
12MP0000377_abnormal_hair_follicle2.50604267
13MP0005257_abnormal_intraocular_pressure2.41353116
14MP0000383_abnormal_hair_follicle2.33169201
15MP0003566_abnormal_cell_adhesion2.25963506
16MP0005501_abnormal_skin_physiology2.25162024
17MP0002254_reproductive_system_inflammat2.18885828
18MP0004381_abnormal_hair_follicle2.17034047
19MP0002877_abnormal_melanocyte_morpholog2.14595946
20MP0005058_abnormal_lysosome_morphology2.04625220
21MP0003453_abnormal_keratinocyte_physiol2.04083758
22MP0006054_spinal_hemorrhage2.03165824
23MP0005408_hypopigmentation1.89911537
24MP0002060_abnormal_skin_morphology1.89497406
25MP0000427_abnormal_hair_cycle1.87121386
26MP0004947_skin_inflammation1.82644421
27MP0004885_abnormal_endolymph1.76818151
28MP0000371_diluted_coat_color1.76131601
29MP0001216_abnormal_epidermal_layer1.65618612
30MP0000367_abnormal_coat/_hair1.58097851
31MP0001958_emphysema1.54207143
32MP0001849_ear_inflammation1.47335760
33MP0001243_abnormal_dermal_layer1.45486894
34MP0009840_abnormal_foam_cell1.44964592
35MP0010771_integument_phenotype1.38953056
36MP0003191_abnormal_cellular_cholesterol1.37728286
37MP0005023_abnormal_wound_healing1.35114920
38MP0003436_decreased_susceptibility_to1.34675149
39MP0004185_abnormal_adipocyte_glucose1.31608325
40MP0002095_abnormal_skin_pigmentation1.29959770
41MP0003172_abnormal_lysosome_physiology1.23024620
42MP0003878_abnormal_ear_physiology1.19798351
43MP0005377_hearing/vestibular/ear_phenot1.19798351
44MP0001542_abnormal_bone_strength1.13611439
45MP0003303_peritoneal_inflammation1.12870418
46MP0004272_abnormal_basement_membrane1.11670897
47MP0003279_aneurysm1.10063484
48MP0000762_abnormal_tongue_morphology1.07898473
49MP0000604_amyloidosis1.04339098
50MP0002234_abnormal_pharynx_morphology1.03930839
51MP0000733_abnormal_muscle_development0.96827719
52MP0009931_abnormal_skin_appearance0.96096282
53MP0001533_abnormal_skeleton_physiology0.92765939
54MP0002998_abnormal_bone_remodeling0.92702001
55MP0005197_abnormal_uvea_morphology0.91926585
56MP0005623_abnormal_meninges_morphology0.91923426
57MP0003448_altered_tumor_morphology0.91376398
58MP0003136_yellow_coat_color0.89889532
59MP0010307_abnormal_tumor_latency0.88833188
60MP0001324_abnormal_eye_pigmentation0.87692098
61MP0000858_altered_metastatic_potential0.87602925
62MP0010352_gastrointestinal_tract_polyps0.87558861
63MP0005670_abnormal_white_adipose0.87103881
64MP0009053_abnormal_anal_canal0.83726084
65MP0003091_abnormal_cell_migration0.83456907
66MP0000343_altered_response_to0.81489053
67MP0005666_abnormal_adipose_tissue0.80375406
68MP0006082_CNS_inflammation0.80180592
69MP0002090_abnormal_vision0.77092881
70MP0002075_abnormal_coat/hair_pigmentati0.74058268
71MP0000627_abnormal_mammary_gland0.73722396
72MP0003950_abnormal_plasma_membrane0.72152747
73MP0005503_abnormal_tendon_morphology0.71783226
74MP0005248_abnormal_Harderian_gland0.71463734
75MP0000015_abnormal_ear_pigmentation0.71142337
76MP0005508_abnormal_skeleton_morphology0.70497042
77MP0004858_abnormal_nervous_system0.69692768
78MP0003300_gastrointestinal_ulcer0.68254971
79MP0000467_abnormal_esophagus_morphology0.67986120
80MP0005083_abnormal_biliary_tract0.65001383
81MP0001851_eye_inflammation0.64795591
82MP0009785_altered_susceptibility_to0.62906843
83MP0005390_skeleton_phenotype0.62370619
84MP0000569_abnormal_digit_pigmentation0.61258157
85MP0003045_fibrosis0.61210574
86MP0000750_abnormal_muscle_regeneration0.60926150
87MP0005375_adipose_tissue_phenotype0.60740802
88MP0005075_abnormal_melanosome_morpholog0.59856455
89MP0005174_abnormal_tail_pigmentation0.59717571
90MP0005076_abnormal_cell_differentiation0.59549044
91MP0005164_abnormal_response_to0.58999436
92MP0001191_abnormal_skin_condition0.57566298
93MP0001879_abnormal_lymphatic_vessel0.55701760
94MP0002970_abnormal_white_adipose0.52900459
95MP0002419_abnormal_innate_immunity0.51486449
96MP0003567_abnormal_fetal_cardiomyocyte0.51265401
97MP0009384_cardiac_valve_regurgitation0.49736130
98MP0002111_abnormal_tail_morphology0.46472813
99MP0001186_pigmentation_phenotype0.46461065
100MP0002837_dystrophic_cardiac_calcinosis0.46048544

Predicted human phenotypes

RankGene SetZ-score
1Hypotrichosis (HP:0001006)8.73650282
2Woolly hair (HP:0002224)6.36812385
3Abnormality of hair growth rate (HP:0011363)6.29468328
4Slow-growing hair (HP:0002217)6.29468328
5Brittle hair (HP:0002299)6.05143729
6Pili torti (HP:0003777)5.99756835
7Nail dystrophy (HP:0008404)5.17710198
8Premature rupture of membranes (HP:0001788)4.28636758
9Alopecia of scalp (HP:0002293)4.23201884
10Right ventricular cardiomyopathy (HP:0011663)4.22915036
11Abnormal hair laboratory examination (HP:0003328)3.83675205
12Onycholysis (HP:0001806)3.78326501
13Fragile nails (HP:0001808)3.70699110
14Abnormality of nail color (HP:0100643)3.43708785
15Systemic lupus erythematosus (HP:0002725)3.33888954
16Congenital sensorineural hearing impairment (HP:0008527)3.29083542
17Follicular hyperkeratosis (HP:0007502)3.18619465
18Abnormality of the frontal sinuses (HP:0002687)3.16992470
19Thick nail (HP:0001805)3.10885170
20Plantar hyperkeratosis (HP:0007556)2.97703562
21Protrusio acetabuli (HP:0003179)2.97118719
22Increased cerebral lipofuscin (HP:0011813)2.95987716
23Mucopolysacchariduria (HP:0008155)2.90676491
24Urinary glycosaminoglycan excretion (HP:0003541)2.90676491
25Increased IgE level (HP:0003212)2.88703801
26Dysostosis multiplex (HP:0000943)2.84983087
27Cervical subluxation (HP:0003308)2.83645119
28Atrophic scars (HP:0001075)2.80412480
29Palmoplantar hyperkeratosis (HP:0000972)2.80225678
30Fine hair (HP:0002213)2.78480230
31Osteolytic defects of the phalanges of the hand (HP:0009771)2.73244908
32Osteolytic defects of the hand bones (HP:0009699)2.73244908
33Aplasia/Hypoplasia of the macula (HP:0008059)2.72402556
34Milia (HP:0001056)2.69588300
35Abnormality of mucopolysaccharide metabolism (HP:0011020)2.65034615
36Abnormality of polysaccharide metabolism (HP:0011012)2.65034615
37Abnormality of glycosaminoglycan metabolism (HP:0004371)2.65034615
38Ridged nail (HP:0001807)2.61886563
39Palmar hyperkeratosis (HP:0010765)2.60346374
40Aplasia/Hypoplasia affecting the retina (HP:0008061)2.57948720
41Increased neuronal autofluorescent lipopigment (HP:0002074)2.45251403
42Spondylolisthesis (HP:0003302)2.43564770
43Ankle contracture (HP:0006466)2.38275248
44Axonal loss (HP:0003447)2.36878013
45Erythema (HP:0010783)2.34322731
46Shallow orbits (HP:0000586)2.33577122
47Distal upper limb amyotrophy (HP:0007149)2.32858390
48Upper limb amyotrophy (HP:0009129)2.32858390
49Ocular albinism (HP:0001107)2.31515350
50Cerebral aneurysm (HP:0004944)2.24495633
51Increased connective tissue (HP:0009025)2.21119204
52Hand muscle atrophy (HP:0009130)2.19480504
53Absent frontal sinuses (HP:0002688)2.19313182
54Subacute progressive viral hepatitis (HP:0006572)2.19051272
55Vacuolated lymphocytes (HP:0001922)2.15894602
56Soft skin (HP:0000977)2.15369697
57Vertebral compression fractures (HP:0002953)2.12792031
58Hyporeflexia of lower limbs (HP:0002600)2.11204804
59Aplasia/Hypoplasia of the fovea (HP:0008060)2.10499255
60Hypoplasia of the fovea (HP:0007750)2.10499255
61Asymmetric septal hypertrophy (HP:0001670)2.10314831
62Neck muscle weakness (HP:0000467)2.07858994
63Peritonitis (HP:0002586)2.05885776
64Wormian bones (HP:0002645)2.04888239
65Delayed closure of the anterior fontanelle (HP:0001476)2.04237728
66Fragile skin (HP:0001030)2.02683548
67Broad metatarsal (HP:0001783)2.02409089
68Natal tooth (HP:0000695)1.99078462
69Curly hair (HP:0002212)1.96961422
70Persistence of primary teeth (HP:0006335)1.91782012
71Aortic aneurysm (HP:0004942)1.91478433
72Blue irides (HP:0000635)1.91120978
73Blue sclerae (HP:0000592)1.90211357
74Sparse eyelashes (HP:0000653)1.89745552
75Scapular winging (HP:0003691)1.87684022
76Elbow flexion contracture (HP:0002987)1.86358564
77Acanthosis nigricans (HP:0000956)1.85691844
78Hypoplasia of the iris (HP:0007676)1.85185825
79Iris hypopigmentation (HP:0007730)1.84247187
80Achilles tendon contracture (HP:0001771)1.80970680
81Myocardial infarction (HP:0001658)1.77959861
82Abnormality of proline metabolism (HP:0010907)1.77213501
83Hydroxyprolinuria (HP:0003080)1.77213501
84Advanced eruption of teeth (HP:0006288)1.74628676
85Abnormality of liposaccharide metabolism (HP:0010968)1.73186865
86Abnormality of glycosphingolipid metabolism (HP:0004343)1.73186865
87Abnormality of glycolipid metabolism (HP:0010969)1.73186865
88Congenital ichthyosiform erythroderma (HP:0007431)1.72032581
89Dilatation of the ascending aorta (HP:0005111)1.71960157
90Loss of speech (HP:0002371)1.70954330
91Ulnar deviation of the wrist (HP:0003049)1.67861188
92Joint stiffness (HP:0001387)1.67572248
93Cutaneous melanoma (HP:0012056)1.67549240
94Oral leukoplakia (HP:0002745)1.65743738
95Distal lower limb amyotrophy (HP:0008944)1.65296703
96Abnormality of macrophages (HP:0004311)1.64625320
97Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.63768944
98Vascular tortuosity (HP:0004948)1.62566390
99Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.61808325
100Abnormality of the fovea (HP:0000493)1.60669386

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST1R5.45808223
2EPHA24.63475312
3TRIB34.33047510
4ERN13.98332239
5PKN23.68891725
6BMX3.31124796
7MET2.60558215
8PAK42.33487828
9FER1.91067253
10EPHB21.83861207
11DDR21.78971450
12TBK11.71283158
13MAPKAPK31.65303996
14MAP3K31.63956178
15PTK61.55766475
16RIPK11.50784228
17TTN1.48769168
18PDGFRA1.48508057
19EPHA31.47241063
20MARK31.39547678
21LRRK21.32271774
22SCYL21.30561191
23PBK1.29439250
24PIM21.28117565
25LATS21.22917852
26KIT1.18135872
27EPHB11.17936105
28MAP3K111.17685852
29MAP3K91.15884607
30KSR21.14422319
31LATS11.12905987
32TYK21.12549514
33TESK11.12308331
34CDK61.04389973
35MAP2K21.03037587
36RPS6KA41.02879815
37MAP2K31.02412189
38SIK10.99634326
39EEF2K0.95932916
40PTK20.95864830
41BLK0.91952344
42MAP3K80.91545182
43TGFBR20.89604748
44TRPM70.88954264
45FGFR40.87423908
46MAP3K60.83804138
47MAP2K10.82941844
48NME20.80583190
49MAP3K20.78909516
50FGFR10.77407826
51ARAF0.76952610
52ABL20.75163844
53RPS6KB20.74970235
54TESK20.73489341
55CAMK1D0.72420574
56TAOK10.71649127
57MOS0.69269216
58ZAP700.66525525
59ILK0.64714595
60PDK20.64560228
61PAK20.61971247
62FGFR30.61679904
63MAPKAPK20.60295493
64MAP3K10.60171687
65PDGFRB0.58801304
66LIMK10.55467438
67MAP3K130.53658116
68FLT30.52987417
69DYRK1B0.52696288
70PRKG20.52002980
71LMTK20.51822485
72GSK3A0.51776378
73JAK10.51696969
74MTOR0.51629269
75ALK0.51603156
76IKBKE0.51553429
77WEE10.49863977
78PAK10.48332378
79RET0.46115269
80BRAF0.46076054
81NEK10.42586569
82DAPK30.42094595
83NME10.41889865
84PDPK10.40431950
85TAOK20.38460325
86SRC0.37738485
87MAP3K50.35377657
88MAP3K100.35126181
89CSNK1A1L0.35028908
90PRKD10.34912515
91EGFR0.34430994
92MATK0.33580372
93PTK2B0.33579135
94CAMKK10.32159220
95CSNK1G30.31296778
96STK100.30448680
97STK30.29894212
98ROCK20.29497166
99INSR0.28672859
100FGR0.28608191

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosaminoglycan degradation_Homo sapiens_hsa005314.40644957
2Lysosome_Homo sapiens_hsa041423.22857992
3Staphylococcus aureus infection_Homo sapiens_hsa051502.40865158
4Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.09396873
5Other glycan degradation_Homo sapiens_hsa005112.02053154
6Mineral absorption_Homo sapiens_hsa049781.98959972
7Tyrosine metabolism_Homo sapiens_hsa003501.91389605
8Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.85708577
9Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.82919023
10ECM-receptor interaction_Homo sapiens_hsa045121.82801790
11Proteoglycans in cancer_Homo sapiens_hsa052051.70496006
12Pertussis_Homo sapiens_hsa051331.69220646
13Malaria_Homo sapiens_hsa051441.67899201
14Central carbon metabolism in cancer_Homo sapiens_hsa052301.60882954
15Osteoclast differentiation_Homo sapiens_hsa043801.59913963
16Apoptosis_Homo sapiens_hsa042101.58951152
17Leishmaniasis_Homo sapiens_hsa051401.57725513
18Caffeine metabolism_Homo sapiens_hsa002321.56426672
19HIF-1 signaling pathway_Homo sapiens_hsa040661.54719470
20Phagosome_Homo sapiens_hsa041451.52838310
21Toll-like receptor signaling pathway_Homo sapiens_hsa046201.45993432
22Bladder cancer_Homo sapiens_hsa052191.45751034
23Toxoplasmosis_Homo sapiens_hsa051451.38511376
24Tuberculosis_Homo sapiens_hsa051521.35497356
25Galactose metabolism_Homo sapiens_hsa000521.34288862
26Amoebiasis_Homo sapiens_hsa051461.32979118
27Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.31588066
28Focal adhesion_Homo sapiens_hsa045101.31056169
29VEGF signaling pathway_Homo sapiens_hsa043701.29337284
30Antigen processing and presentation_Homo sapiens_hsa046121.29229076
31Melanoma_Homo sapiens_hsa052181.27150501
32Legionellosis_Homo sapiens_hsa051341.23219526
33Sphingolipid metabolism_Homo sapiens_hsa006001.23201513
34Adherens junction_Homo sapiens_hsa045201.22544980
35Small cell lung cancer_Homo sapiens_hsa052221.20073909
36Chronic myeloid leukemia_Homo sapiens_hsa052201.19605961
37Pentose phosphate pathway_Homo sapiens_hsa000301.18944225
38Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.17855978
39Melanogenesis_Homo sapiens_hsa049161.14783596
40Renal cell carcinoma_Homo sapiens_hsa052111.11873587
41TNF signaling pathway_Homo sapiens_hsa046681.11632331
42Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.10290949
43Salmonella infection_Homo sapiens_hsa051321.08711561
44Leukocyte transendothelial migration_Homo sapiens_hsa046701.07556221
45Rheumatoid arthritis_Homo sapiens_hsa053231.06628375
46Shigellosis_Homo sapiens_hsa051311.05307984
47Complement and coagulation cascades_Homo sapiens_hsa046101.05197767
48Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.95131999
49AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.95093507
50Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.92307417
51Vibrio cholerae infection_Homo sapiens_hsa051100.89026988
52PPAR signaling pathway_Homo sapiens_hsa033200.88971538
53MicroRNAs in cancer_Homo sapiens_hsa052060.87286576
54Hepatitis C_Homo sapiens_hsa051600.87068098
55Histidine metabolism_Homo sapiens_hsa003400.86623613
56Acute myeloid leukemia_Homo sapiens_hsa052210.86486399
57Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.84392928
58Thyroid cancer_Homo sapiens_hsa052160.83133784
59p53 signaling pathway_Homo sapiens_hsa041150.81764642
60Glioma_Homo sapiens_hsa052140.79974488
61Adipocytokine signaling pathway_Homo sapiens_hsa049200.76781986
62Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.72156201
63PI3K-Akt signaling pathway_Homo sapiens_hsa041510.70295687
64Influenza A_Homo sapiens_hsa051640.70239628
65Prion diseases_Homo sapiens_hsa050200.67739281
66Regulation of actin cytoskeleton_Homo sapiens_hsa048100.65156399
67Fructose and mannose metabolism_Homo sapiens_hsa000510.64796200
68Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.64298788
69Tight junction_Homo sapiens_hsa045300.63609902
70Neurotrophin signaling pathway_Homo sapiens_hsa047220.63375031
71Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.62574455
72Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.62174030
73Hepatitis B_Homo sapiens_hsa051610.61631166
74Prostate cancer_Homo sapiens_hsa052150.60957546
75mTOR signaling pathway_Homo sapiens_hsa041500.60452581
76Pancreatic cancer_Homo sapiens_hsa052120.59812781
77Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.59114117
78Basal cell carcinoma_Homo sapiens_hsa052170.59058729
79* Fat digestion and absorption_Homo sapiens_hsa049750.58982666
80Insulin resistance_Homo sapiens_hsa049310.58722063
81Viral carcinogenesis_Homo sapiens_hsa052030.57968597
82Sphingolipid signaling pathway_Homo sapiens_hsa040710.55509929
83Thyroid hormone synthesis_Homo sapiens_hsa049180.53639051
84Starch and sucrose metabolism_Homo sapiens_hsa005000.52925316
85B cell receptor signaling pathway_Homo sapiens_hsa046620.51666759
86Pathways in cancer_Homo sapiens_hsa052000.51332123
87Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.50429296
88Carbon metabolism_Homo sapiens_hsa012000.50255847
89Rap1 signaling pathway_Homo sapiens_hsa040150.49308213
90Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.49026506
91Systemic lupus erythematosus_Homo sapiens_hsa053220.47943131
92Endocytosis_Homo sapiens_hsa041440.47278605
93Glutathione metabolism_Homo sapiens_hsa004800.45545543
94Pentose and glucuronate interconversions_Homo sapiens_hsa000400.44934325
95Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.44629702
96HTLV-I infection_Homo sapiens_hsa051660.44049804
97Endometrial cancer_Homo sapiens_hsa052130.43928965
98Biosynthesis of amino acids_Homo sapiens_hsa012300.43738049
99Dilated cardiomyopathy_Homo sapiens_hsa054140.43723353
100Fatty acid biosynthesis_Homo sapiens_hsa000610.42577692

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