PLA2G3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that belongs to the secreted phospholipase A2 family, whose members include the bee venom enzyme. The encoded enzyme functions in lipid metabolism and catalyzes the calcium-dependent hydrolysis of the sn-2 acyl bond of phospholipids to release arachidonic acid and lysophospholipids. This enzyme acts as a negative regulator of ciliogenesis, and may play a role in cancer development by stimulating tumor cell growth and angiogenesis. This gene is associated with oxidative stress, and polymorphisms in this gene are linked to risk for Alzheimer's disease. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of posttranscriptional gene silencing (GO:0060147)5.87731719
2regulation of gene silencing by miRNA (GO:0060964)5.87731719
3regulation of gene silencing by RNA (GO:0060966)5.87731719
4L-serine metabolic process (GO:0006563)5.22151512
5establishment of integrated proviral latency (GO:0075713)4.97464890
6pre-miRNA processing (GO:0031054)4.95773832
7axon ensheathment in central nervous system (GO:0032291)4.92004430
8central nervous system myelination (GO:0022010)4.92004430
9synaptic vesicle maturation (GO:0016188)4.87676820
10paraxial mesoderm development (GO:0048339)4.64207494
11heterochromatin organization (GO:0070828)4.52439900
12cellular potassium ion homeostasis (GO:0030007)4.49641855
13sodium ion export (GO:0071436)4.36597499
14vocalization behavior (GO:0071625)4.34150631
15IMP biosynthetic process (GO:0006188)4.24042294
16auditory behavior (GO:0031223)4.21163217
17chromatin remodeling at centromere (GO:0031055)4.20955210
18potassium ion homeostasis (GO:0055075)4.17312693
19DNA replication checkpoint (GO:0000076)4.17072375
20protein complex localization (GO:0031503)4.12911981
21regulation of short-term neuronal synaptic plasticity (GO:0048172)4.10574759
22regulation of cell fate specification (GO:0042659)4.07939825
23L-amino acid import (GO:0043092)4.03904204
24keratinization (GO:0031424)4.02868121
25CENP-A containing nucleosome assembly (GO:0034080)3.97557948
26nucleobase biosynthetic process (GO:0046112)3.88645625
27neurotransmitter uptake (GO:0001504)3.87237914
28IMP metabolic process (GO:0046040)3.86169021
29fatty acid elongation (GO:0030497)3.83764321
30purine nucleobase biosynthetic process (GO:0009113)3.79533284
31cellular sodium ion homeostasis (GO:0006883)3.79467583
32DNA unwinding involved in DNA replication (GO:0006268)3.79189590
33neuronal action potential propagation (GO:0019227)3.74601835
34protein localization to kinetochore (GO:0034501)3.72904346
35DNA strand elongation involved in DNA replication (GO:0006271)3.72254581
36positive regulation of SMAD protein import into nucleus (GO:0060391)3.70602874
37nuclear pore complex assembly (GO:0051292)3.67890363
38establishment of viral latency (GO:0019043)3.67771185
39DNA strand renaturation (GO:0000733)3.67341191
40response to auditory stimulus (GO:0010996)3.66787553
41synaptic vesicle exocytosis (GO:0016079)3.65305075
42ionotropic glutamate receptor signaling pathway (GO:0035235)3.62938784
43positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.62590800
44amino acid import (GO:0043090)3.60681363
45DNA replication-independent nucleosome assembly (GO:0006336)3.60446990
46DNA replication-independent nucleosome organization (GO:0034724)3.60446990
47potassium ion import (GO:0010107)3.58634479
48gamma-aminobutyric acid transport (GO:0015812)3.57182311
49mechanosensory behavior (GO:0007638)3.52797341
50DNA strand elongation (GO:0022616)3.51197695
51mitotic metaphase plate congression (GO:0007080)3.50384248
52negative regulation of gene silencing (GO:0060969)3.44759705
53histone exchange (GO:0043486)3.44405482
54L-alpha-amino acid transmembrane transport (GO:1902475)3.44088840
55cell fate commitment involved in formation of primary germ layer (GO:0060795)3.39928505
56membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.38679105
57planar cell polarity pathway involved in neural tube closure (GO:0090179)3.38346273
58cellular protein complex localization (GO:0034629)3.37789362
59locomotory exploration behavior (GO:0035641)3.36261615
60regulation of Wnt signaling pathway involved in heart development (GO:0003307)3.34526723
61detection of temperature stimulus involved in sensory perception (GO:0050961)3.33434282
62detection of temperature stimulus involved in sensory perception of pain (GO:0050965)3.33434282
63glutamate receptor signaling pathway (GO:0007215)3.33373650
64nuclear pore organization (GO:0006999)3.29768661
65positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.27875684
66DNA replication-dependent nucleosome organization (GO:0034723)3.24049907
67DNA replication-dependent nucleosome assembly (GO:0006335)3.24049907
68negative regulation of chromosome segregation (GO:0051985)3.23274463
69glutamate secretion (GO:0014047)3.22206960
70negative regulation of mitotic sister chromatid separation (GO:2000816)3.21290014
71negative regulation of sister chromatid segregation (GO:0033046)3.21290014
72negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.21290014
73negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.21290014
74negative regulation of mitotic sister chromatid segregation (GO:0033048)3.21290014
75regulation of helicase activity (GO:0051095)3.21246447
76cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.19248411
77convergent extension (GO:0060026)3.19036544
78negative regulation of cell fate commitment (GO:0010454)3.17809728
79negative regulation of synaptic transmission, GABAergic (GO:0032229)3.17521107
80regulation of nuclear cell cycle DNA replication (GO:0033262)3.15557277
81serine family amino acid biosynthetic process (GO:0009070)3.15205672
82establishment of mitochondrion localization (GO:0051654)3.15181251
83cell communication by electrical coupling (GO:0010644)3.13773813
84protein localization to chromosome, centromeric region (GO:0071459)3.13639196
85telomere maintenance via semi-conservative replication (GO:0032201)3.13470959
86detection of temperature stimulus (GO:0016048)3.12621573
87regulation of synaptic vesicle exocytosis (GO:2000300)3.11663768
88regulation of gene silencing (GO:0060968)3.07880304
89negative regulation of cell fate specification (GO:0009996)3.07860957
90negative regulation of telomerase activity (GO:0051974)3.07616585
91response to methylmercury (GO:0051597)3.06933758
92long-chain fatty acid biosynthetic process (GO:0042759)3.06850211
93ribosomal small subunit assembly (GO:0000028)3.06453142
94regulation of cell fate commitment (GO:0010453)3.06262675
95transmission of nerve impulse (GO:0019226)3.06165691
96positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.05930296
97innervation (GO:0060384)3.05181270
98sodium ion homeostasis (GO:0055078)3.04707364
99neuron recognition (GO:0008038)3.03908982
100neurotransmitter secretion (GO:0007269)3.03637443
101photoreceptor cell differentiation (GO:0046530)3.03103177
102eye photoreceptor cell differentiation (GO:0001754)3.03103177
103ATP-dependent chromatin remodeling (GO:0043044)3.02964759
104regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.01861970
105regulation of neuronal synaptic plasticity (GO:0048168)3.01836145
106glycine transport (GO:0015816)3.01180422
107gamma-aminobutyric acid signaling pathway (GO:0007214)3.00837691
108DNA replication initiation (GO:0006270)3.00713723
109DNA ligation (GO:0006266)2.97263650
110negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.97032007
111negative regulation of translation, ncRNA-mediated (GO:0040033)2.97032007
112regulation of translation, ncRNA-mediated (GO:0045974)2.97032007
113neurotransmitter transport (GO:0006836)2.96673025
114synaptic transmission, glutamatergic (GO:0035249)2.95177698
115histone arginine methylation (GO:0034969)2.94443176
116neuron cell-cell adhesion (GO:0007158)2.92513828
117membrane hyperpolarization (GO:0060081)2.92420533
118cerebellar Purkinje cell differentiation (GO:0021702)2.92167034
119regulation of mitotic spindle checkpoint (GO:1903504)2.91814396
120regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.91814396
121positive regulation of potassium ion transmembrane transport (GO:1901381)2.91604836
122DNA damage response, detection of DNA damage (GO:0042769)2.91092843
123mitotic spindle checkpoint (GO:0071174)2.87892792
124C4-dicarboxylate transport (GO:0015740)2.87030607
125regulation of chromosome segregation (GO:0051983)2.86695494
126regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.85205478
127regulation of synaptic vesicle transport (GO:1902803)2.85131179
128regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.84614325
129regulation of mitotic metaphase/anaphase transition (GO:0030071)2.84614325
130lung-associated mesenchyme development (GO:0060484)2.84444324
131cell migration in hindbrain (GO:0021535)2.84151472
132regulation of histone H3-K9 methylation (GO:0051570)2.83272415
133spindle checkpoint (GO:0031577)2.83223945
134DNA double-strand break processing (GO:0000729)2.82856477
135chromatin assembly or disassembly (GO:0006333)2.82632550
136lysine metabolic process (GO:0006553)2.82166321
137lysine catabolic process (GO:0006554)2.82166321
138G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.81059575
139neuronal ion channel clustering (GO:0045161)2.80822816
140cell communication involved in cardiac conduction (GO:0086065)2.80316497
141axonal fasciculation (GO:0007413)2.78910884
142regulation of sister chromatid segregation (GO:0033045)2.78712707
143regulation of mitotic sister chromatid separation (GO:0010965)2.78712707
144regulation of mitotic sister chromatid segregation (GO:0033047)2.78712707
145membrane depolarization during action potential (GO:0086010)2.78694437
146regulation of long-term neuronal synaptic plasticity (GO:0048169)2.77996492
147regulation of neurotransmitter levels (GO:0001505)2.77624159
148regulation of translational fidelity (GO:0006450)2.76025426
149mitotic sister chromatid segregation (GO:0000070)2.75771251
150DNA topological change (GO:0006265)2.74879137
151metaphase plate congression (GO:0051310)2.74158677
152layer formation in cerebral cortex (GO:0021819)2.74095240
153notochord development (GO:0030903)2.74073784
154mitotic spindle assembly checkpoint (GO:0007094)2.73954582
155myelination (GO:0042552)2.73573212
156regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.73261777
157regulation of stem cell maintenance (GO:2000036)2.71976005
158cerebellar granule cell differentiation (GO:0021707)2.71142220
159regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.71070284
160axon ensheathment (GO:0008366)2.70862105
161ensheathment of neurons (GO:0007272)2.70862105
162neuron-neuron synaptic transmission (GO:0007270)2.70733969
163establishment of apical/basal cell polarity (GO:0035089)2.69096716
164positive regulation of chromosome segregation (GO:0051984)2.68621569
165neuron remodeling (GO:0016322)2.67648271
166regulation of chromatin silencing (GO:0031935)2.67387162
167protein localization to synapse (GO:0035418)2.67093638
168positive regulation of potassium ion transport (GO:0043268)2.66673297
169mitotic nuclear envelope disassembly (GO:0007077)2.66556863
170anterior/posterior axis specification, embryo (GO:0008595)2.66395421
171spindle assembly checkpoint (GO:0071173)2.65935840
172protein-DNA complex disassembly (GO:0032986)2.65934277
173nucleosome disassembly (GO:0006337)2.65934277
174negative regulation of mitosis (GO:0045839)2.65283588
175lateral sprouting from an epithelium (GO:0060601)2.62986920
176adult walking behavior (GO:0007628)2.62699784
177proline transport (GO:0015824)2.61122411
178cerebral cortex radially oriented cell migration (GO:0021799)2.60943568
179neurotransmitter catabolic process (GO:0042135)2.58678577
180regulation of synapse structural plasticity (GO:0051823)2.56615075
181regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.56378940
182negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.56030153
183negative regulation of protein localization to cell surface (GO:2000009)2.55859113
184regulation of glutamate receptor signaling pathway (GO:1900449)2.55327976
185startle response (GO:0001964)2.55105276
186regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.53799848
187synaptic vesicle docking involved in exocytosis (GO:0016081)2.52663619
188dendrite morphogenesis (GO:0048813)2.50091926
189neuromuscular process controlling balance (GO:0050885)2.48949593
190negative regulation of cytosolic calcium ion concentration (GO:0051481)2.48347741
191neurofilament cytoskeleton organization (GO:0060052)2.47704963
192exploration behavior (GO:0035640)2.47387628
193G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.47209571
194regulation of cardiac muscle cell contraction (GO:0086004)2.46085715
195cochlea development (GO:0090102)2.45469408
196acidic amino acid transport (GO:0015800)2.43472180
197substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.41938052
198substrate-independent telencephalic tangential migration (GO:0021826)2.41938052
199negative regulation of neurotransmitter transport (GO:0051589)2.41904894
200neuronal action potential (GO:0019228)2.39586167

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.66961047
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.31122316
3EZH2_22144423_ChIP-Seq_EOC_Human3.85046487
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.61981676
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.52357713
6GBX2_23144817_ChIP-Seq_PC3_Human3.18074278
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.13023581
8MYC_19079543_ChIP-ChIP_MESCs_Mouse3.10502564
9KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.93510446
10KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.93510446
11KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.93510446
12SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.91463384
13KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.86471065
14MYC_19030024_ChIP-ChIP_MESCs_Mouse2.84297968
15SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.83806481
16JARID2_20064375_ChIP-Seq_MESCs_Mouse2.72922639
17CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.60924402
18HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.60695571
19EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.59358164
20MYC_18358816_ChIP-ChIP_MESCs_Mouse2.48435266
21RNF2_18974828_ChIP-Seq_MESCs_Mouse2.45271670
22EZH2_18974828_ChIP-Seq_MESCs_Mouse2.45271670
23JARID2_20075857_ChIP-Seq_MESCs_Mouse2.42775022
24MTF2_20144788_ChIP-Seq_MESCs_Mouse2.42456667
25SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.41693481
26POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.38548065
27SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.32609101
28SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.31808720
29SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.31225898
30XRN2_22483619_ChIP-Seq_HELA_Human2.26790805
31NELFA_20434984_ChIP-Seq_ESCs_Mouse2.24841884
32DROSHA_22980978_ChIP-Seq_HELA_Human2.21382276
33POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.20504791
34EZH2_27304074_Chip-Seq_ESCs_Mouse2.17496596
35MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.16026665
36EED_16625203_ChIP-ChIP_MESCs_Mouse2.14105380
37NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.14042991
38SUZ12_27294783_Chip-Seq_ESCs_Mouse2.12364370
39EST1_17652178_ChIP-ChIP_JURKAT_Human2.12358426
40EZH2_27294783_Chip-Seq_ESCs_Mouse2.11222753
41MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.11129507
42GABP_17652178_ChIP-ChIP_JURKAT_Human2.10788360
43AR_21572438_ChIP-Seq_LNCaP_Human2.10705846
44SALL1_21062744_ChIP-ChIP_HESCs_Human2.06726325
45RNF2_27304074_Chip-Seq_ESCs_Mouse2.06534286
46KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.03039654
47NANOG_18555785_ChIP-Seq_MESCs_Mouse2.00611942
48E2F1_18555785_ChIP-Seq_MESCs_Mouse2.00497710
49CREB1_15753290_ChIP-ChIP_HEK293T_Human1.99296808
50SOX2_16153702_ChIP-ChIP_HESCs_Human1.99115570
51POU5F1_16153702_ChIP-ChIP_HESCs_Human1.97072977
52E2F1_21310950_ChIP-Seq_MCF-7_Human1.96837000
53THAP11_20581084_ChIP-Seq_MESCs_Mouse1.95240321
54AR_21909140_ChIP-Seq_LNCAP_Human1.95026155
55REST_21632747_ChIP-Seq_MESCs_Mouse1.94871541
56NANOG_16153702_ChIP-ChIP_HESCs_Human1.93222836
57NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.93079334
58ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.91909403
59SOX2_18555785_ChIP-Seq_MESCs_Mouse1.90420129
60MYCN_18555785_ChIP-Seq_MESCs_Mouse1.86937610
61JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.85734557
62TCF3_18692474_ChIP-Seq_MEFs_Mouse1.82754091
63E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.78870911
64ETS1_20019798_ChIP-Seq_JURKAT_Human1.75181049
65IKZF1_21737484_ChIP-ChIP_HCT116_Human1.73920774
66TTF2_22483619_ChIP-Seq_HELA_Human1.71099534
67TP63_19390658_ChIP-ChIP_HaCaT_Human1.62052317
68PIAS1_25552417_ChIP-Seq_VCAP_Human1.59085576
69ZFX_18555785_ChIP-Seq_MESCs_Mouse1.58831984
70CTBP2_25329375_ChIP-Seq_LNCAP_Human1.57536537
71RARB_27405468_Chip-Seq_BRAIN_Mouse1.56731019
72CDX2_19796622_ChIP-Seq_MESCs_Mouse1.56524029
73YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.56219882
74GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.53702448
75DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.53368566
76CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.52991701
77VDR_22108803_ChIP-Seq_LS180_Human1.51630303
78ZFP57_27257070_Chip-Seq_ESCs_Mouse1.49999490
79TCF3_18692474_ChIP-Seq_MESCs_Mouse1.48668674
80PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.48404052
81* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.47394837
82TAF15_26573619_Chip-Seq_HEK293_Human1.46616632
83SMAD4_21799915_ChIP-Seq_A2780_Human1.46089047
84ELK1_19687146_ChIP-ChIP_HELA_Human1.44815843
85REST_18959480_ChIP-ChIP_MESCs_Mouse1.44251443
86NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.43930694
87ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.42698886
88ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.42290362
89CTBP1_25329375_ChIP-Seq_LNCAP_Human1.41821546
90KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.39556298
91ARNT_22903824_ChIP-Seq_MCF-7_Human1.39477685
92SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.39209455
93TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.38714569
94VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.38628128
95SMAD_19615063_ChIP-ChIP_OVARY_Human1.37760154
96POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.36035732
97BMI1_23680149_ChIP-Seq_NPCS_Mouse1.35556533
98FOXP3_21729870_ChIP-Seq_TREG_Human1.35354739
99SMAD3_21741376_ChIP-Seq_EPCs_Human1.35022953
100ERG_21242973_ChIP-ChIP_JURKAT_Human1.34575381
101P300_19829295_ChIP-Seq_ESCs_Human1.32621636
102YY1_21170310_ChIP-Seq_MESCs_Mouse1.31219317
103SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.31135528
104DCP1A_22483619_ChIP-Seq_HELA_Human1.30997418
105OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.30422915
106AHR_22903824_ChIP-Seq_MCF-7_Human1.29893825
107CBX2_27304074_Chip-Seq_ESCs_Mouse1.27317503
108SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.26116478
109GABP_19822575_ChIP-Seq_HepG2_Human1.25714367
110SOX2_18692474_ChIP-Seq_MEFs_Mouse1.25515927
111ZNF217_24962896_ChIP-Seq_MCF-7_Human1.25393236
112SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.24687471
113RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.24665576
114NR3C1_23031785_ChIP-Seq_PC12_Mouse1.24470425
115HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.24373654
116AR_25329375_ChIP-Seq_VCAP_Human1.24363881
117RING1B_27294783_Chip-Seq_ESCs_Mouse1.23801739
118KLF4_18555785_ChIP-Seq_MESCs_Mouse1.23468135
119CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.21647312
120PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.21119789
121SOX2_21211035_ChIP-Seq_LN229_Gbm1.19573743
122BCAT_22108803_ChIP-Seq_LS180_Human1.17292421
123NANOG_21062744_ChIP-ChIP_HESCs_Human1.17102051
124STAT3_23295773_ChIP-Seq_U87_Human1.17100552
125WT1_25993318_ChIP-Seq_PODOCYTE_Human1.15335287
126MYC_18940864_ChIP-ChIP_HL60_Human1.14666287
127TOP2B_26459242_ChIP-Seq_MCF-7_Human1.14374599
128NR3C1_21868756_ChIP-Seq_MCF10A_Human1.13783994
129ZFP281_18757296_ChIP-ChIP_E14_Mouse1.13632651
130ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.13189188
131SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.13014981
132RXR_22108803_ChIP-Seq_LS180_Human1.12872786
133EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.12649161
134* SOX2_18692474_ChIP-Seq_MESCs_Mouse1.11813900
135AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.10265147
136PADI4_21655091_ChIP-ChIP_MCF-7_Human1.09268581
137CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.09244322
138ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.09109689
139TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08927772
140TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.08288806
141CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.07760249
142MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.06758376
143POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.05693922
144E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.05188396
145TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.05088595
146PRDM14_20953172_ChIP-Seq_ESCs_Human1.05032607
147AR_19668381_ChIP-Seq_PC3_Human1.04912645
148ZNF274_21170338_ChIP-Seq_K562_Hela1.03773558
149NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.03062930
150FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.02585319
151MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.01392773
152MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.00854113
153OCT4_18692474_ChIP-Seq_MEFs_Mouse1.00340285
154P53_22127205_ChIP-Seq_FIBROBLAST_Human1.00104244
155RING1B_27294783_Chip-Seq_NPCs_Mouse0.99911491
156PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.99786551
157POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.98285795
158BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.98018997
159NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.97699146
160ESR2_21235772_ChIP-Seq_MCF-7_Human0.97626837
161HOXB4_20404135_ChIP-ChIP_EML_Mouse0.96166419
162POU3F2_20337985_ChIP-ChIP_501MEL_Human0.96038407
163RUNX2_22187159_ChIP-Seq_PCA_Human0.95546058
164UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.95534965
165TCF4_23295773_ChIP-Seq_U87_Human0.95503921
166CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.94769182
167KAP1_27257070_Chip-Seq_ESCs_Mouse0.94386626
168RBPJ_22232070_ChIP-Seq_NCS_Mouse0.93503024
169GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93220933
170SMAD4_21741376_ChIP-Seq_HESCs_Human0.93053141
171PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.92490471
172RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.92249101
173SMAD3_21741376_ChIP-Seq_HESCs_Human0.91407794
174NANOG_18692474_ChIP-Seq_MEFs_Mouse0.91323625
175* YAP1_20516196_ChIP-Seq_MESCs_Mouse0.91185846
176CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.90597342
177SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.90418088
178EP300_21415370_ChIP-Seq_HL-1_Mouse0.89682679
179VDR_23849224_ChIP-Seq_CD4+_Human0.89430088
180NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.89303044
181NRF2_20460467_ChIP-Seq_MEFs_Mouse0.89303044
182TRIM28_21343339_ChIP-Seq_HEK293_Human0.89111266
183TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.88817114
184TP53_18474530_ChIP-ChIP_U2OS_Human0.88786080
185STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.88726275
186KDM2B_26808549_Chip-Seq_K562_Human0.88206166
187GATA1_26923725_Chip-Seq_HPCs_Mouse0.87948960
188STAT3_1855785_ChIP-Seq_MESCs_Mouse0.87117987
189TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.86851338
190POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.86851338
191HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.86801113
192DNAJC2_21179169_ChIP-ChIP_NT2_Human0.86468843
193NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.86178031
194NANOG_18692474_ChIP-Seq_MESCs_Mouse0.86070473
195RNF2_27304074_Chip-Seq_NSC_Mouse0.85970433
196SMAD3_21741376_ChIP-Seq_ESCs_Human0.84845594
197CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.83645119
198SOX17_20123909_ChIP-Seq_XEN_Mouse0.83001278
199KDM5A_27292631_Chip-Seq_BREAST_Human0.81991643

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003941_abnormal_skin_development4.76467632
2MP0004859_abnormal_synaptic_plasticity4.24198441
3MP0004270_analgesia3.98332858
4MP0003693_abnormal_embryo_hatching3.50786256
5MP0003880_abnormal_central_pattern3.38415483
6MP0004957_abnormal_blastocyst_morpholog3.33336417
7MP0002735_abnormal_chemical_nociception3.09215935
8MP0003635_abnormal_synaptic_transmissio2.99748977
9MP0003111_abnormal_nucleus_morphology2.98569407
10MP0002734_abnormal_mechanical_nocicepti2.83937180
11MP0001968_abnormal_touch/_nociception2.72721249
12MP0005423_abnormal_somatic_nervous2.71668650
13MP0010030_abnormal_orbit_morphology2.67163207
14MP0002272_abnormal_nervous_system2.66644747
15MP0004885_abnormal_endolymph2.63966683
16MP0010094_abnormal_chromosome_stability2.57981169
17MP0009745_abnormal_behavioral_response2.55520144
18MP0001188_hyperpigmentation2.54815042
19MP0009046_muscle_twitch2.54457917
20MP0002736_abnormal_nociception_after2.54258508
21MP0002064_seizures2.53433198
22MP0001486_abnormal_startle_reflex2.52499508
23MP0002063_abnormal_learning/memory/cond2.42607852
24MP0003890_abnormal_embryonic-extraembry2.38991271
25MP0002822_catalepsy2.37966611
26MP0006292_abnormal_olfactory_placode2.36455219
27MP0008932_abnormal_embryonic_tissue2.36337209
28MP0003329_amyloid_beta_deposits2.34601458
29MP0004858_abnormal_nervous_system2.29742876
30MP0008057_abnormal_DNA_replication2.28956294
31MP0002572_abnormal_emotion/affect_behav2.28924205
32MP0003690_abnormal_glial_cell2.26806924
33MP0002733_abnormal_thermal_nociception2.24014630
34MP0009672_abnormal_birth_weight2.21629022
35MP0008058_abnormal_DNA_repair2.19004288
36MP0005501_abnormal_skin_physiology2.18274041
37MP0001970_abnormal_pain_threshold2.11229137
38MP0000920_abnormal_myelination2.06850033
39MP0001293_anophthalmia2.06657051
40MP0001485_abnormal_pinna_reflex2.06070321
41MP0008569_lethality_at_weaning2.03756240
42MP0003077_abnormal_cell_cycle2.02299643
43MP0001501_abnormal_sleep_pattern2.00921096
44MP0008877_abnormal_DNA_methylation1.92773794
45MP0002067_abnormal_sensory_capabilities1.92260373
46MP0000778_abnormal_nervous_system1.90497499
47MP0003718_maternal_effect1.86422441
48MP0003136_yellow_coat_color1.85023166
49MP0001440_abnormal_grooming_behavior1.82595751
50MP0003567_abnormal_fetal_cardiomyocyte1.80275340
51MP0003633_abnormal_nervous_system1.68250137
52MP0003937_abnormal_limbs/digits/tail_de1.67841304
53MP0000955_abnormal_spinal_cord1.60180279
54MP0002697_abnormal_eye_size1.58679706
55MP0004133_heterotaxia1.58277459
56MP0003119_abnormal_digestive_system1.57613916
57MP0001502_abnormal_circadian_rhythm1.56564144
58MP0001730_embryonic_growth_arrest1.55274891
59MP0002184_abnormal_innervation1.54774275
60MP0009379_abnormal_foot_pigmentation1.54244336
61MP0002085_abnormal_embryonic_tissue1.53069392
62MP0006276_abnormal_autonomic_nervous1.52709604
63MP0004142_abnormal_muscle_tone1.52425988
64MP0010234_abnormal_vibrissa_follicle1.50763318
65MP0002111_abnormal_tail_morphology1.49581950
66MP0003634_abnormal_glial_cell1.49308558
67MP0004043_abnormal_pH_regulation1.48984125
68MP0002557_abnormal_social/conspecific_i1.46936922
69MP0008007_abnormal_cellular_replicative1.46275869
70MP0001529_abnormal_vocalization1.46195161
71MP0000566_synostosis1.45569947
72MP0005386_behavior/neurological_phenoty1.44032708
73MP0004924_abnormal_behavior1.44032708
74MP0002229_neurodegeneration1.42824470
75MP0003631_nervous_system_phenotype1.41164285
76* MP0005380_embryogenesis_phenotype1.40039456
77* MP0001672_abnormal_embryogenesis/_devel1.40039456
78MP0004742_abnormal_vestibular_system1.39925175
79MP0001881_abnormal_mammary_gland1.39842415
80MP0002084_abnormal_developmental_patter1.39435138
81MP0002254_reproductive_system_inflammat1.39116971
82MP0002938_white_spotting1.39003557
83MP0008789_abnormal_olfactory_epithelium1.37088806
84MP0005645_abnormal_hypothalamus_physiol1.37007258
85MP0002882_abnormal_neuron_morphology1.33239861
86MP0001905_abnormal_dopamine_level1.32983705
87MP0010352_gastrointestinal_tract_polyps1.32346051
88MP0002066_abnormal_motor_capabilities/c1.31405438
89MP0003879_abnormal_hair_cell1.30987010
90MP0005167_abnormal_blood-brain_barrier1.26967911
91MP0001963_abnormal_hearing_physiology1.26965473
92MP0001697_abnormal_embryo_size1.26828386
93MP0004197_abnormal_fetal_growth/weight/1.25356497
94MP0003878_abnormal_ear_physiology1.24089159
95MP0005377_hearing/vestibular/ear_phenot1.24089159
96MP0003984_embryonic_growth_retardation1.23801965
97MP0001286_abnormal_eye_development1.23370489
98MP0000350_abnormal_cell_proliferation1.22404357
99MP0005171_absent_coat_pigmentation1.21400233
100MP0002088_abnormal_embryonic_growth/wei1.20209421
101MP0005499_abnormal_olfactory_system1.19735786
102MP0005394_taste/olfaction_phenotype1.19735786
103MP0009703_decreased_birth_body1.18350681
104MP0005551_abnormal_eye_electrophysiolog1.14877256
105MP0000049_abnormal_middle_ear1.14290136
106MP0004811_abnormal_neuron_physiology1.13874766
107MP0002233_abnormal_nose_morphology1.12410104
108* MP0002080_prenatal_lethality1.12091294
109MP0002796_impaired_skin_barrier1.11733022
110MP0003632_abnormal_nervous_system1.10050500
111MP0000537_abnormal_urethra_morphology1.09827430
112MP0001299_abnormal_eye_distance/1.07333352
113MP0001348_abnormal_lacrimal_gland1.05023873
114MP0002876_abnormal_thyroid_physiology1.04223814
115MP0000604_amyloidosis1.03726125
116MP0003861_abnormal_nervous_system1.03259686
117MP0010678_abnormal_skin_adnexa1.02607082
118MP0003705_abnormal_hypodermis_morpholog1.02073082
119MP0001984_abnormal_olfaction1.00637592
120MP0001346_abnormal_lacrimal_gland0.98514198
121MP0000647_abnormal_sebaceous_gland0.97487022
122MP0003122_maternal_imprinting0.97328952
123MP0002752_abnormal_somatic_nervous0.95776871
124MP0005409_darkened_coat_color0.95773593
125MP0005646_abnormal_pituitary_gland0.95221170
126MP0000762_abnormal_tongue_morphology0.94878554
127MP0009780_abnormal_chondrocyte_physiolo0.94872844
128MP0003453_abnormal_keratinocyte_physiol0.94591517
129MP0003121_genomic_imprinting0.93472918
130MP0003755_abnormal_palate_morphology0.93450734
131MP0009384_cardiac_valve_regurgitation0.91580757
132MP0000377_abnormal_hair_follicle0.90451238
133MP0000428_abnormal_craniofacial_morphol0.90130436
134MP0002653_abnormal_ependyma_morphology0.89774948
135MP0010771_integument_phenotype0.88319389
136MP0003123_paternal_imprinting0.88106954
137MP0000432_abnormal_head_morphology0.86266649
138MP0003315_abnormal_perineum_morphology0.85681375
139MP0000026_abnormal_inner_ear0.84557569
140MP0001216_abnormal_epidermal_layer0.83574121
141MP0002086_abnormal_extraembryonic_tissu0.83165309
142MP0003137_abnormal_impulse_conducting0.82853589
143MP0002089_abnormal_postnatal_growth/wei0.82037949
144MP0002152_abnormal_brain_morphology0.81817875
145MP0002210_abnormal_sex_determination0.81187393
146MP0003938_abnormal_ear_development0.80960853
147MP0006072_abnormal_retinal_apoptosis0.80399479
148MP0004215_abnormal_myocardial_fiber0.80288112
149MP0001986_abnormal_taste_sensitivity0.80131347
150MP0000751_myopathy0.78936413
151MP0009053_abnormal_anal_canal0.78519075
152MP0008874_decreased_physiological_sensi0.77875402
153MP0003075_altered_response_to0.77660165
154MP0002092_abnormal_eye_morphology0.76949291
155MP0004264_abnormal_extraembryonic_tissu0.75942793
156MP0004147_increased_porphyrin_level0.74477621
157MP0002069_abnormal_eating/drinking_beha0.73967978
158MP0000467_abnormal_esophagus_morphology0.72168788
159MP0000372_irregular_coat_pigmentation0.71742329
160MP0004085_abnormal_heartbeat0.71641364
161MP0001664_abnormal_digestion0.71134128
162MP0000579_abnormal_nail_morphology0.70595875
163MP0000490_abnormal_crypts_of0.70326864
164MP0000313_abnormal_cell_death0.69883619
165MP0000462_abnormal_digestive_system0.69258241
166* MP0001145_abnormal_male_reproductive0.69193499
167MP0004036_abnormal_muscle_relaxation0.68975448
168MP0002060_abnormal_skin_morphology0.68221341
169MP0001177_atelectasis0.68006748
170MP0004145_abnormal_muscle_electrophysio0.67300990
171MP0005647_abnormal_sex_gland0.66868364
172MP0008872_abnormal_physiological_respon0.66842549
173MP0009697_abnormal_copulation0.66377756
174MP0005275_abnormal_skin_tensile0.65907894
175MP0003942_abnormal_urinary_system0.64809965
176MP0002081_perinatal_lethality0.64634438
177MP0002751_abnormal_autonomic_nervous0.62954142
178MP0003045_fibrosis0.62914241
179MP0010307_abnormal_tumor_latency0.62815014
180MP0003786_premature_aging0.61245905
181MP0003566_abnormal_cell_adhesion0.60956994
182MP0008770_decreased_survivor_rate0.60502364
183MP0001943_abnormal_respiration0.58440553
184MP0001849_ear_inflammation0.58067713
185MP0000747_muscle_weakness0.56739604
186MP0005535_abnormal_body_temperature0.55752480

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)5.60771964
2Focal motor seizures (HP:0011153)5.27769944
3Action tremor (HP:0002345)4.79328274
4Supranuclear gaze palsy (HP:0000605)4.51401077
5Focal seizures (HP:0007359)4.35242337
6Septo-optic dysplasia (HP:0100842)4.18345612
7Colon cancer (HP:0003003)4.08310427
8Abnormality of nail color (HP:0100643)4.03258096
9Neurofibrillary tangles (HP:0002185)4.00310779
10Hemiparesis (HP:0001269)3.92665544
11Abnormality of the labia minora (HP:0012880)3.52514187
12Epileptic encephalopathy (HP:0200134)3.51266807
13Febrile seizures (HP:0002373)3.47644861
14Ulnar claw (HP:0001178)3.44834124
15Progressive cerebellar ataxia (HP:0002073)3.40569634
16Pheochromocytoma (HP:0002666)3.39278366
17Onion bulb formation (HP:0003383)3.36526772
18Abnormality of the corticospinal tract (HP:0002492)3.31586453
19Hemiplegia (HP:0002301)3.26676712
20Truncal ataxia (HP:0002078)3.25683339
21Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.22698602
22Degeneration of the lateral corticospinal tracts (HP:0002314)3.22698602
23Ankle clonus (HP:0011448)3.20447604
24Dysmetria (HP:0001310)3.20263308
25Cerebral inclusion bodies (HP:0100314)3.10016690
26Insidious onset (HP:0003587)3.06176422
27Termporal pattern (HP:0011008)3.06176422
28Diplopia (HP:0000651)3.05323645
29Abnormality of binocular vision (HP:0011514)3.05323645
30Dysdiadochokinesis (HP:0002075)3.03470256
31Oral leukoplakia (HP:0002745)3.03174483
32Choanal stenosis (HP:0000452)2.98947702
33Selective tooth agenesis (HP:0001592)2.96683368
34Increased hepatocellular lipid droplets (HP:0006565)2.93634426
35Neuroendocrine neoplasm (HP:0100634)2.87198958
36Atonic seizures (HP:0010819)2.87092652
37Aplasia involving bones of the upper limbs (HP:0009823)2.86887887
38Aplasia of the phalanges of the hand (HP:0009802)2.86887887
39Aplasia involving bones of the extremities (HP:0009825)2.86887887
40Generalized tonic-clonic seizures (HP:0002069)2.84871816
41Megalencephaly (HP:0001355)2.82348937
42Spastic gait (HP:0002064)2.80672390
43Scanning speech (HP:0002168)2.79929985
44Spastic diplegia (HP:0001264)2.77381102
45Absence seizures (HP:0002121)2.77367835
46Birth length less than 3rd percentile (HP:0003561)2.75534297
47Peripheral hypomyelination (HP:0007182)2.75448997
48Abnormal lung lobation (HP:0002101)2.74326284
49Metabolic alkalosis (HP:0200114)2.72066414
50Dialeptic seizures (HP:0011146)2.69536812
51Intention tremor (HP:0002080)2.68929893
52Visual hallucinations (HP:0002367)2.68513126
53Maternal diabetes (HP:0009800)2.67317005
54Nephroblastoma (Wilms tumor) (HP:0002667)2.64584013
55Erythroderma (HP:0001019)2.62980939
56Cortical dysplasia (HP:0002539)2.62895547
57Lipid accumulation in hepatocytes (HP:0006561)2.61367595
58Urinary urgency (HP:0000012)2.60499434
59Multiple enchondromatosis (HP:0005701)2.58569273
60Hyperglycinemia (HP:0002154)2.51560722
61Absent septum pellucidum (HP:0001331)2.49831292
62Decreased number of peripheral myelinated nerve fibers (HP:0003380)2.49711363
63Confusion (HP:0001289)2.49194564
64Hepatoblastoma (HP:0002884)2.47304833
65Meckel diverticulum (HP:0002245)2.46944627
66Reticulocytopenia (HP:0001896)2.45040672
67Partial duplication of thumb phalanx (HP:0009944)2.43444675
68Embryonal renal neoplasm (HP:0011794)2.41991524
69Breast aplasia (HP:0100783)2.41279860
70Rectovaginal fistula (HP:0000143)2.39537909
71Rectal fistula (HP:0100590)2.39537909
72Facial shape deformation (HP:0011334)2.38735103
73Potter facies (HP:0002009)2.38735103
74Steppage gait (HP:0003376)2.38491491
75Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.37934775
76Chromosomal breakage induced by crosslinking agents (HP:0003221)2.37738656
77Segmental peripheral demyelination/remyelination (HP:0003481)2.37574170
78Homocystinuria (HP:0002156)2.36712358
79Abnormality of homocysteine metabolism (HP:0010919)2.36712358
80Rib fusion (HP:0000902)2.34197817
81Hyperventilation (HP:0002883)2.33601743
82Lower limb muscle weakness (HP:0007340)2.33203199
83Aplasia/Hypoplasia of the breasts (HP:0010311)2.33099026
84Absent eyelashes (HP:0000561)2.33055221
85Vaginal fistula (HP:0004320)2.32486787
86Bifid tongue (HP:0010297)2.30334630
87Increased circulating renin level (HP:0000848)2.28901681
88Abnormality of the ileum (HP:0001549)2.28884323
89Gaze-evoked nystagmus (HP:0000640)2.27325238
90Absent hair (HP:0002298)2.27172862
91Hammertoe (HP:0001765)2.26426746
92Chromsome breakage (HP:0040012)2.24252570
93Myelomeningocele (HP:0002475)2.23910638
94Abnormality of the septum pellucidum (HP:0007375)2.23681807
95Postural instability (HP:0002172)2.23128152
96Coronal craniosynostosis (HP:0004440)2.22442909
97Impaired social interactions (HP:0000735)2.21828360
98Abnormal social behavior (HP:0012433)2.21828360
99Slow saccadic eye movements (HP:0000514)2.21704639
100Absent speech (HP:0001344)2.19407579
101Limb dystonia (HP:0002451)2.17498899
102Retinal dysplasia (HP:0007973)2.17188575
103Anxiety (HP:0000739)2.17133431
104Absent radius (HP:0003974)2.16539093
105Bilateral microphthalmos (HP:0007633)2.15909306
106High anterior hairline (HP:0009890)2.15771313
107Abnormal auditory evoked potentials (HP:0006958)2.15544958
108Hyperglycinuria (HP:0003108)2.14583080
109Depression (HP:0000716)2.14109743
110Foot dorsiflexor weakness (HP:0009027)2.12373196
111Abdominal situs inversus (HP:0003363)2.11890891
112Abnormality of abdominal situs (HP:0011620)2.11890891
113Abnormality of the salivary glands (HP:0010286)2.09987680
114Intestinal fistula (HP:0100819)2.09783565
115Abnormality of glycine metabolism (HP:0010895)2.09098146
116Abnormality of serine family amino acid metabolism (HP:0010894)2.09098146
117Turricephaly (HP:0000262)2.08710702
118Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.07791902
119Decreased motor nerve conduction velocity (HP:0003431)2.07271049
120Palmar hyperkeratosis (HP:0010765)2.06875540
121Increased nuchal translucency (HP:0010880)2.05390470
122Ependymoma (HP:0002888)2.04641342
123Poor eye contact (HP:0000817)2.03323705
124Gait ataxia (HP:0002066)2.02749911
125Abnormal eating behavior (HP:0100738)2.01931468
126Prolonged QT interval (HP:0001657)2.00199373
127Aplasia involving forearm bones (HP:0009822)1.99572746
128Absent forearm bone (HP:0003953)1.99572746
129Symphalangism affecting the phalanges of the hand (HP:0009773)1.99226304
130Urinary bladder sphincter dysfunction (HP:0002839)1.98041255
131Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.97923246
132Abnormality of the foot musculature (HP:0001436)1.97526134
133Palmoplantar hyperkeratosis (HP:0000972)1.97347607
134Non-midline cleft lip (HP:0100335)1.96701898
135Broad-based gait (HP:0002136)1.96606283
136Squamous cell carcinoma (HP:0002860)1.96244670
137Chronic bronchitis (HP:0004469)1.95993572
138Pterygium (HP:0001059)1.95262808
139Partial duplication of the phalanx of hand (HP:0009999)1.95238583
140Abnormality of serum amino acid levels (HP:0003112)1.95205449
141Generalized hypotonia (HP:0001290)1.94672258
142Distal sensory impairment (HP:0002936)1.94634287
143Abnormality of placental membranes (HP:0011409)1.93457314
144Amniotic constriction ring (HP:0009775)1.93457314
145Horseshoe kidney (HP:0000085)1.92605810
146Specific learning disability (HP:0001328)1.91626459
147Duplication of thumb phalanx (HP:0009942)1.91310420
148Poikiloderma (HP:0001029)1.90687467
149Aqueductal stenosis (HP:0002410)1.89898842
150Preauricular skin tag (HP:0000384)1.89556296
151Abnormality of the preputium (HP:0100587)1.87489023
152Increased IgE level (HP:0003212)1.86638778
153Hypoplasia of the pons (HP:0012110)1.85668162
154Widely patent fontanelles and sutures (HP:0004492)1.85491391
155Abnormality of the lacrimal duct (HP:0011481)1.84477179
156Aplasia/Hypoplasia of the sternum (HP:0006714)1.83109960
157Blue irides (HP:0000635)1.82860227
158Stereotypic behavior (HP:0000733)1.82525587
159Abnormality of chromosome stability (HP:0003220)1.81020540
160Facial cleft (HP:0002006)1.80778176
161Ventricular fibrillation (HP:0001663)1.80190967
162Hypoglycemic seizures (HP:0002173)1.80084583
163Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.79909990
164Parakeratosis (HP:0001036)1.79766845
165Gait imbalance (HP:0002141)1.78273891
166Renal Fanconi syndrome (HP:0001994)1.77253614
167Postural tremor (HP:0002174)1.76424678
168EEG with generalized epileptiform discharges (HP:0011198)1.76373244
169Ectopic kidney (HP:0000086)1.75204044
170Aplasia/Hypoplasia of the uvula (HP:0010293)1.74562160
171Clumsiness (HP:0002312)1.73434587
172Epileptiform EEG discharges (HP:0011182)1.73296579
173Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.73184586
174Optic nerve hypoplasia (HP:0000609)1.72900152
175Bradycardia (HP:0001662)1.72236493
176Stenosis of the external auditory canal (HP:0000402)1.71992766
177Congenital ichthyosiform erythroderma (HP:0007431)1.71745494
178Abnormality of cochlea (HP:0000375)1.71698410
179Abnormality of cells of the erythroid lineage (HP:0012130)1.71580601
180Triphalangeal thumb (HP:0001199)1.71348896
181Skull defect (HP:0001362)1.70971880
182Atresia of the external auditory canal (HP:0000413)1.70062061
183Abnormality of saccadic eye movements (HP:0000570)1.69978881
184Macrocytic anemia (HP:0001972)1.69554415
185Hypsarrhythmia (HP:0002521)1.69503891
186Rhabdomyosarcoma (HP:0002859)1.69470755
187Hyperinsulinemic hypoglycemia (HP:0000825)1.69230612
188Rigidity (HP:0002063)1.69153390
189Hypoplastic left heart (HP:0004383)1.68258019
190Neoplasm of the peripheral nervous system (HP:0100007)1.68064359
191Generalized myoclonic seizures (HP:0002123)1.67370831
192Impulsivity (HP:0100710)1.67295000
193Synostosis involving the elbow (HP:0003938)1.67100974
194Humeroradial synostosis (HP:0003041)1.67100974
195Progressive inability to walk (HP:0002505)1.66783548
196Abnormal number of erythroid precursors (HP:0012131)1.65706763
197Supernumerary spleens (HP:0009799)1.65403882
198Megaloblastic anemia (HP:0001889)1.64284391
199Biliary tract neoplasm (HP:0100574)1.63456300

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.12638807
2NTRK33.61055458
3TSSK63.39982692
4TTK3.37632742
5SRPK13.22594366
6BUB13.17545074
7VRK23.05317894
8TAF13.01768002
9MKNK22.81495518
10MKNK12.71683511
11STK392.68911199
12PLK32.57567532
13NTRK12.56721051
14LMTK22.44116343
15BRSK22.25076634
16MINK12.24919456
17MAP3K92.22627727
18ZAK2.21409379
19NTRK22.19266514
20CASK2.15458521
21PLK42.06712523
22MAP3K102.05281464
23MARK12.03061492
24WNK11.88705139
25EPHA41.87872444
26DYRK21.84917850
27KSR21.78849452
28PAK61.78151684
29MUSK1.74631808
30SMG11.69615100
31PHKG21.68502269
32PHKG11.68502269
33EPHB11.66802686
34OXSR11.65621651
35PLK11.63877086
36PBK1.63161958
37DDR21.62484155
38SGK4941.61017194
39SGK2231.61017194
40MAP2K71.59705471
41TYRO31.59540949
42CHEK21.59397766
43PINK11.58885622
44WNK41.58343641
45MAP3K41.56654103
46TNIK1.56275577
47NEK11.38386759
48CDK51.35673383
49PASK1.32935388
50WNK31.30557280
51DYRK31.29742723
52MAPKAPK51.29529494
53TRIM281.27899908
54PKN11.24843762
55VRK11.24106420
56MAP2K41.23994516
57CAMK2B1.22058641
58BMX1.21166516
59MST41.20677597
60NUAK11.18606999
61STK161.18463984
62WEE11.18031674
63DAPK21.16888817
64ATR1.16419793
65CAMK2D1.13816987
66MAP3K21.11265337
67CAMK2A1.11127718
68PAK41.10609915
69UHMK11.09929396
70CAMK1D1.09503327
71BRSK11.09446786
72NME11.08327680
73CDC42BPA1.08213475
74EEF2K1.07153974
75RIPK41.05387974
76LIMK11.05108410
77NEK21.03827013
78FGR1.03231266
79ROCK21.02955189
80PNCK1.02866863
81PRKCE1.02827835
82CAMK2G1.01949874
83TIE10.99075544
84PDPK10.98700819
85ALK0.98338349
86MAPK130.97755073
87GRK50.96346967
88MAP3K120.94374059
89STK240.93842913
90CHEK10.91451847
91BCR0.90569863
92STK380.90227984
93MAP2K20.89302989
94NLK0.88657542
95CDK70.88048106
96PRKCG0.87087231
97STK30.84946590
98MARK20.84744123
99FGFR20.82316113
100AURKB0.82148292
101FGFR40.81219844
102PIK3CA0.80895043
103SGK20.80319303
104ATM0.80061859
105STK38L0.79268927
106PAK30.77908760
107CAMKK10.77322172
108SGK10.77066886
109CSNK1G10.74928281
110MAP2K10.74434167
111KSR10.74349572
112MAPK120.73692428
113PRKD30.73238117
114FER0.72826050
115BRD40.72627610
116CDK190.71405274
117CDK140.70898322
118RET0.70563870
119SGK30.70426013
120LATS20.69301411
121PDK10.69175782
122PRKCH0.68354215
123DYRK1A0.68317955
124CDK60.67237477
125CAMK1G0.65138191
126EIF2AK20.64926828
127TGFBR10.63239625
128PRKG10.63227522
129CSNK1E0.63010349
130CDK10.62911145
131STK110.62676736
132CDK20.62635715
133BMPR20.61806949
134LATS10.61123300
135FYN0.60622610
136AURKA0.59268406
137STK40.58032708
138CSNK1A1L0.57860887
139CSNK1G20.57562334
140ADRBK10.57130105
141CDK180.55181632
142CDK150.55129272
143MAPK150.52479298
144MAP3K70.52324243
145CSNK1G30.51600909
146PRKDC0.51584872
147CSNK1A10.51330955
148DMPK0.50780560
149FES0.50012614
150MATK0.49630778
151PRKACA0.49195561
152MAP3K80.48607409
153PRKD10.48426556
154BRAF0.48299678
155ERBB40.47104529
156PRKCA0.46634587
157PLK20.46203616
158CDK11A0.45786628
159CAMKK20.45336982
160ARAF0.45214246
161GRK70.44953053
162PRKCQ0.44554172
163CSNK2A20.43783018
164CSNK2A10.43749557
165SRC0.43665155
166FGFR10.43242869
167MAPK100.43032102
168RPS6KA40.42957741
169RPS6KA10.41792385
170CDK40.41037007
171PIM10.39405245
172KDR0.37976931
173RPS6KB20.37420051
174EPHA20.34374206
175CDK30.33912986
176PTK60.32201865
177NME20.31787038
178PAK10.29327727
179MET0.27947722

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.55455443
2Mismatch repair_Homo sapiens_hsa034303.21792681
3Nitrogen metabolism_Homo sapiens_hsa009102.95396885
4Nicotine addiction_Homo sapiens_hsa050332.75594618
5Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.56711437
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.52426548
7Spliceosome_Homo sapiens_hsa030402.46116059
8Ribosome_Homo sapiens_hsa030102.42658837
9GABAergic synapse_Homo sapiens_hsa047272.40691481
10Base excision repair_Homo sapiens_hsa034102.30823937
11RNA transport_Homo sapiens_hsa030132.29266237
12Non-homologous end-joining_Homo sapiens_hsa034502.21083129
13Glutamatergic synapse_Homo sapiens_hsa047242.17295705
142-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.16633052
15Circadian entrainment_Homo sapiens_hsa047132.12087466
16Salivary secretion_Homo sapiens_hsa049702.11875393
17Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.11854894
18Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.10852931
19Cell cycle_Homo sapiens_hsa041102.10290619
20RNA polymerase_Homo sapiens_hsa030202.09986685
21Proteasome_Homo sapiens_hsa030502.03238715
22Synaptic vesicle cycle_Homo sapiens_hsa047212.01525783
23Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.96980349
24Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.96113166
25Cysteine and methionine metabolism_Homo sapiens_hsa002701.95723660
26Homologous recombination_Homo sapiens_hsa034401.95618227
27Biosynthesis of amino acids_Homo sapiens_hsa012301.90904139
28One carbon pool by folate_Homo sapiens_hsa006701.90731628
29Steroid biosynthesis_Homo sapiens_hsa001001.86872858
30Morphine addiction_Homo sapiens_hsa050321.86279464
31Gastric acid secretion_Homo sapiens_hsa049711.82991871
32Selenocompound metabolism_Homo sapiens_hsa004501.78011942
33Pyruvate metabolism_Homo sapiens_hsa006201.73557095
34Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.72393117
35Nucleotide excision repair_Homo sapiens_hsa034201.71275322
36Amphetamine addiction_Homo sapiens_hsa050311.68484596
37Olfactory transduction_Homo sapiens_hsa047401.66591478
38mRNA surveillance pathway_Homo sapiens_hsa030151.64671656
39Long-term potentiation_Homo sapiens_hsa047201.64536119
40Insulin secretion_Homo sapiens_hsa049111.61935606
41Serotonergic synapse_Homo sapiens_hsa047261.61334935
42Vitamin B6 metabolism_Homo sapiens_hsa007501.60976606
43Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.60773110
44Fatty acid elongation_Homo sapiens_hsa000621.58083224
45Caffeine metabolism_Homo sapiens_hsa002321.57783859
46Fanconi anemia pathway_Homo sapiens_hsa034601.56815818
47Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.53580131
48Taste transduction_Homo sapiens_hsa047421.52765973
49Dopaminergic synapse_Homo sapiens_hsa047281.52399655
50Cocaine addiction_Homo sapiens_hsa050301.48792952
51Basal transcription factors_Homo sapiens_hsa030221.48408342
52Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.46014890
53Cholinergic synapse_Homo sapiens_hsa047251.43582846
54RNA degradation_Homo sapiens_hsa030181.41799678
55Renin secretion_Homo sapiens_hsa049241.41441561
56Basal cell carcinoma_Homo sapiens_hsa052171.39436608
57Long-term depression_Homo sapiens_hsa047301.38191576
58Dorso-ventral axis formation_Homo sapiens_hsa043201.34441740
59Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.34356670
60Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.30739552
61Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.30397266
62Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.28760772
63Protein export_Homo sapiens_hsa030601.21825590
64Pyrimidine metabolism_Homo sapiens_hsa002401.21107603
65Calcium signaling pathway_Homo sapiens_hsa040201.20207794
66Carbon metabolism_Homo sapiens_hsa012001.16324330
67Gap junction_Homo sapiens_hsa045401.14095831
68Bile secretion_Homo sapiens_hsa049761.13246237
69Aldosterone synthesis and secretion_Homo sapiens_hsa049251.11085337
70* Pancreatic secretion_Homo sapiens_hsa049721.09733479
71Axon guidance_Homo sapiens_hsa043601.09487300
72Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.07979969
73Cardiac muscle contraction_Homo sapiens_hsa042601.07352937
74Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.05677970
75* Ether lipid metabolism_Homo sapiens_hsa005651.05350548
76Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.05157355
77Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.04143308
78Hippo signaling pathway_Homo sapiens_hsa043901.03301376
79Histidine metabolism_Homo sapiens_hsa003401.02362999
80Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.02184251
81Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.02073723
82Vitamin digestion and absorption_Homo sapiens_hsa049771.01744651
83cAMP signaling pathway_Homo sapiens_hsa040240.99193257
84Lysine degradation_Homo sapiens_hsa003100.98988582
85Propanoate metabolism_Homo sapiens_hsa006400.98243568
86Sulfur metabolism_Homo sapiens_hsa009200.97403073
87Mineral absorption_Homo sapiens_hsa049780.97191627
88GnRH signaling pathway_Homo sapiens_hsa049120.96908661
89Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.95697913
90Thyroid cancer_Homo sapiens_hsa052160.95627958
91Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.95138829
92Oxytocin signaling pathway_Homo sapiens_hsa049210.94792885
93Huntingtons disease_Homo sapiens_hsa050160.94782662
94Adherens junction_Homo sapiens_hsa045200.92233418
95Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.92059318
96Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.91739128
97Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.91648152
98ErbB signaling pathway_Homo sapiens_hsa040120.91383593
99Galactose metabolism_Homo sapiens_hsa000520.90689169
100Hedgehog signaling pathway_Homo sapiens_hsa043400.90535107
101Phosphatidylinositol signaling system_Homo sapiens_hsa040700.90448334
102Purine metabolism_Homo sapiens_hsa002300.90245936
103Estrogen signaling pathway_Homo sapiens_hsa049150.89567032
104Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.88966608
105Fatty acid biosynthesis_Homo sapiens_hsa000610.86974512
106Wnt signaling pathway_Homo sapiens_hsa043100.86144149
107Thyroid hormone synthesis_Homo sapiens_hsa049180.84367043
108Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.83365015
109p53 signaling pathway_Homo sapiens_hsa041150.82016416
110cGMP-PKG signaling pathway_Homo sapiens_hsa040220.81871889
111Melanogenesis_Homo sapiens_hsa049160.80902214
112Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.80076571
113Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.79103534
114* Vascular smooth muscle contraction_Homo sapiens_hsa042700.78509957
115Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.78136653
116Phototransduction_Homo sapiens_hsa047440.78118288
117Phospholipase D signaling pathway_Homo sapiens_hsa040720.77694011
118Oocyte meiosis_Homo sapiens_hsa041140.77234865
119Sulfur relay system_Homo sapiens_hsa041220.76566343
120Collecting duct acid secretion_Homo sapiens_hsa049660.74061941
121Sphingolipid signaling pathway_Homo sapiens_hsa040710.74001027
122Butanoate metabolism_Homo sapiens_hsa006500.73732679
123Arginine and proline metabolism_Homo sapiens_hsa003300.71948819
124Choline metabolism in cancer_Homo sapiens_hsa052310.70930466
125Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.70534645
126Type II diabetes mellitus_Homo sapiens_hsa049300.69817500
127Sphingolipid metabolism_Homo sapiens_hsa006000.69452544
128Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.68036245
129Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.65920724
130Glutathione metabolism_Homo sapiens_hsa004800.65066989
131Carbohydrate digestion and absorption_Homo sapiens_hsa049730.63471271
132* Glycerophospholipid metabolism_Homo sapiens_hsa005640.61513804
133Alzheimers disease_Homo sapiens_hsa050100.61206555
134Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.60848552
135Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.60717978
136Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.60093708
137* Metabolic pathways_Homo sapiens_hsa011000.57242163
138Dilated cardiomyopathy_Homo sapiens_hsa054140.57124765
139MicroRNAs in cancer_Homo sapiens_hsa052060.56995405
140Fatty acid metabolism_Homo sapiens_hsa012120.56795940
141Glioma_Homo sapiens_hsa052140.55797803
142Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.54649001
143* Ras signaling pathway_Homo sapiens_hsa040140.52211031
144Oxidative phosphorylation_Homo sapiens_hsa001900.51131482
145Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.51094808
146Central carbon metabolism in cancer_Homo sapiens_hsa052300.50676491
147Vibrio cholerae infection_Homo sapiens_hsa051100.49689666
148Pentose phosphate pathway_Homo sapiens_hsa000300.48905966
149Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.48890373
150Tight junction_Homo sapiens_hsa045300.46869333
151Inositol phosphate metabolism_Homo sapiens_hsa005620.45305620
152VEGF signaling pathway_Homo sapiens_hsa043700.45159897
153Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.44687291
154Folate biosynthesis_Homo sapiens_hsa007900.43962405
155MAPK signaling pathway_Homo sapiens_hsa040100.42696548
156Rap1 signaling pathway_Homo sapiens_hsa040150.40420213
157Arginine biosynthesis_Homo sapiens_hsa002200.39486587
158beta-Alanine metabolism_Homo sapiens_hsa004100.39128713
159Endocytosis_Homo sapiens_hsa041440.39057422
160Ovarian steroidogenesis_Homo sapiens_hsa049130.37286108
161Fatty acid degradation_Homo sapiens_hsa000710.37104219
162Renal cell carcinoma_Homo sapiens_hsa052110.36867259
163Parkinsons disease_Homo sapiens_hsa050120.35804303
164Cyanoamino acid metabolism_Homo sapiens_hsa004600.35236947
165Colorectal cancer_Homo sapiens_hsa052100.35081276
166Glycerolipid metabolism_Homo sapiens_hsa005610.33761950
167ABC transporters_Homo sapiens_hsa020100.32667511
168Pentose and glucuronate interconversions_Homo sapiens_hsa000400.32008254
169N-Glycan biosynthesis_Homo sapiens_hsa005100.31124694
170Thyroid hormone signaling pathway_Homo sapiens_hsa049190.30912500
171TGF-beta signaling pathway_Homo sapiens_hsa043500.25986677
172Fructose and mannose metabolism_Homo sapiens_hsa000510.25704511
173* Fat digestion and absorption_Homo sapiens_hsa049750.22298936
174Prostate cancer_Homo sapiens_hsa052150.21665209
175Notch signaling pathway_Homo sapiens_hsa043300.21655688
176* alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.21450889
177Tryptophan metabolism_Homo sapiens_hsa003800.20876608
178Bladder cancer_Homo sapiens_hsa052190.15700089

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