PLA2G4A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the cytosolic phospholipase A2 group IV family. The enzyme catalyzes the hydrolysis of membrane phospholipids to release arachidonic acid which is subsequently metabolized into eicosanoids. Eicosanoids, including prostaglandins and leukotrienes, are lipid-based cellular hormones that regulate hemodynamics, inflammatory responses, and other intracellular pathways. The hydrolysis reaction also produces lysophospholipids that are converted into platelet-activating factor. The enzyme is activated by increased intracellular Ca(2+) levels and phosphorylation, resulting in its translocation from the cytosol and nucleus to perinuclear membrane vesicles. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)4.71453163
2central nervous system myelination (GO:0022010)4.71453163
3neutrophil activation involved in immune response (GO:0002283)4.58197251
4antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.36276138
5production of molecular mediator involved in inflammatory response (GO:0002532)4.24708574
6regulation of vitamin D biosynthetic process (GO:0060556)4.15695400
7fatty acid elongation (GO:0030497)4.11303953
8regulation of vitamin metabolic process (GO:0030656)3.89896270
9regulation of integrin activation (GO:0033623)3.81972311
10amyloid precursor protein metabolic process (GO:0042982)3.79910345
11negative regulation of interleukin-12 production (GO:0032695)3.79491906
12regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.69856018
13hemidesmosome assembly (GO:0031581)3.63456342
14definitive hemopoiesis (GO:0060216)3.56880342
15lipopolysaccharide-mediated signaling pathway (GO:0031663)3.55485535
16cell adhesion mediated by integrin (GO:0033627)3.53364487
17leukocyte migration involved in inflammatory response (GO:0002523)3.48403388
18platelet dense granule organization (GO:0060155)3.36738294
19regulation of interferon-alpha production (GO:0032647)3.36272555
20regulation of T cell migration (GO:2000404)3.29893519
21positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.24752911
22membrane raft organization (GO:0031579)3.24588340
23phagocytosis, engulfment (GO:0006911)3.20065005
24positive regulation of type 2 immune response (GO:0002830)3.15298277
25cyclooxygenase pathway (GO:0019371)3.14458299
26negative regulation of inflammatory response to antigenic stimulus (GO:0002862)3.13452409
27cellular response to interferon-alpha (GO:0035457)3.10016707
28mesodermal cell differentiation (GO:0048333)3.07689061
29response to interferon-beta (GO:0035456)3.04494943
30regulation of lymphocyte migration (GO:2000401)3.03630942
31interleukin-6-mediated signaling pathway (GO:0070102)3.03610461
32low-density lipoprotein particle clearance (GO:0034383)3.00658473
33positive regulation of mitochondrial calcium ion concentration (GO:0051561)3.00400493
34detection of molecule of bacterial origin (GO:0032490)2.99554003
35keratan sulfate catabolic process (GO:0042340)2.98775545
36immunoglobulin mediated immune response (GO:0016064)2.98621476
37negative regulation of nitric oxide biosynthetic process (GO:0045019)2.96815363
38positive regulation of chemokine secretion (GO:0090197)2.96491876
39cellular response to ATP (GO:0071318)2.95452282
40glycosphingolipid catabolic process (GO:0046479)2.94810579
41response to interferon-alpha (GO:0035455)2.92706169
42regulation of membrane protein ectodomain proteolysis (GO:0051043)2.90474878
43response to lipoprotein particle (GO:0055094)2.88799778
44negative regulation of leukocyte chemotaxis (GO:0002689)2.87858319
45myelin maintenance (GO:0043217)2.87739251
46myeloid cell homeostasis (GO:0002262)2.85298996
47positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.84239735
48regulation of fever generation (GO:0031620)2.84002423
49ensheathment of neurons (GO:0007272)2.83922631
50axon ensheathment (GO:0008366)2.83922631
51myelination (GO:0042552)2.83609948
52positive regulation of T-helper cell differentiation (GO:0045624)2.83453125
53cellular response to thyroid hormone stimulus (GO:0097067)2.82268952
54regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.82028063
55positive regulation of macrophage cytokine production (GO:0060907)2.81372152
56mesenchymal-epithelial cell signaling (GO:0060638)2.80723779
57regulation of mononuclear cell migration (GO:0071675)2.80522519
58amyloid precursor protein catabolic process (GO:0042987)2.79494316
59positive regulation of chemokine biosynthetic process (GO:0045080)2.75846147
60lipoxygenase pathway (GO:0019372)2.75248365
61adhesion of symbiont to host cell (GO:0044650)2.73941649
62virion attachment to host cell (GO:0019062)2.73941649
63skin morphogenesis (GO:0043589)2.73452326
64positive regulation of interleukin-6 production (GO:0032755)2.72014202
65negative regulation of vascular permeability (GO:0043116)2.71967140
66negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.69184938
67macrophage activation involved in immune response (GO:0002281)2.68139534
68hyaluronan catabolic process (GO:0030214)2.67378001
69cellular response to type I interferon (GO:0071357)2.67332763
70type I interferon signaling pathway (GO:0060337)2.67332763
71regulation of podosome assembly (GO:0071801)2.67105511
72signal peptide processing (GO:0006465)2.66594970
73oligosaccharide catabolic process (GO:0009313)2.66297135
74hepatocyte apoptotic process (GO:0097284)2.64257758
75response to type I interferon (GO:0034340)2.63713820
76respiratory burst (GO:0045730)2.62503783
77regulation of chemokine biosynthetic process (GO:0045073)2.62107432
78regulation of cytokine secretion involved in immune response (GO:0002739)2.61409283
79long-chain fatty acid biosynthetic process (GO:0042759)2.60850978
80glycolipid catabolic process (GO:0019377)2.60307867
81response to peptidoglycan (GO:0032494)2.60166514
82B cell mediated immunity (GO:0019724)2.60138388
83modulation of growth of symbiont involved in interaction with host (GO:0044144)2.60085685
84regulation of growth of symbiont in host (GO:0044126)2.60085685
85negative regulation of growth of symbiont in host (GO:0044130)2.60085685
86negative regulation of growth of symbiont involved in interaction with host (GO:0044146)2.60085685
87pinocytosis (GO:0006907)2.59723345
88cellular response to lipopolysaccharide (GO:0071222)2.59646594
89positive regulation of heat generation (GO:0031652)2.59628232
90regulation of T-helper cell differentiation (GO:0045622)2.59530435
91regulation of dendritic cell antigen processing and presentation (GO:0002604)2.59159740
92neutrophil activation (GO:0042119)2.58993247
93regulation of T-helper 2 cell differentiation (GO:0045628)2.58606613
94iron ion import (GO:0097286)2.56150906
95wound healing, spreading of epidermal cells (GO:0035313)2.56144207
96regulation of type 2 immune response (GO:0002828)2.55790630
97regulation of macrophage cytokine production (GO:0010935)2.55668878
98regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.54942173
99positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.54597422
100Arp2/3 complex-mediated actin nucleation (GO:0034314)2.54484414
101regulation of interleukin-8 secretion (GO:2000482)2.54294578
102positive regulation of actin filament depolymerization (GO:0030836)2.54258022
103positive regulation of interleukin-10 production (GO:0032733)2.54228814
104natural killer cell mediated immunity (GO:0002228)2.53670611
105natural killer cell mediated cytotoxicity (GO:0042267)2.53670611
106regulation of interleukin-12 production (GO:0032655)2.53609904
107myeloid cell activation involved in immune response (GO:0002275)2.53557751
108apoptotic cell clearance (GO:0043277)2.53423175
109response to thyroid hormone (GO:0097066)2.53206741
110histamine secretion (GO:0001821)2.53016561
111negative regulation of interleukin-8 production (GO:0032717)2.52685711
112megakaryocyte development (GO:0035855)2.52570054
113positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.52437589
114interferon-gamma-mediated signaling pathway (GO:0060333)2.52279860
115regulation of metalloenzyme activity (GO:0048552)2.51204932
116T-helper 1 type immune response (GO:0042088)2.50198188
117negative regulation of complement activation (GO:0045916)2.49756726
118negative regulation of hydrogen peroxide-induced cell death (GO:1903206)2.49551413
119positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.49466044
120leukocyte degranulation (GO:0043299)2.49407219
121positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.48673532
122cellular response to molecule of bacterial origin (GO:0071219)2.48390922
123wound healing, spreading of cells (GO:0044319)2.48380748
124chondrocyte proliferation (GO:0035988)2.48233764
125cholesterol biosynthetic process (GO:0006695)2.47842452
126positive regulation of acute inflammatory response (GO:0002675)2.46645119
127vesicle fusion (GO:0006906)2.46457832
128mast cell activation (GO:0045576)2.46150734
129regulation of monocyte chemotaxis (GO:0090025)2.46025154
130response to protozoan (GO:0001562)2.45763650
131negative regulation of interleukin-17 production (GO:0032700)2.45308372
132regulation of hypersensitivity (GO:0002883)2.45111740
133regulation of T-helper 1 cell differentiation (GO:0045625)2.45048072
134positive regulation of T cell migration (GO:2000406)2.44338749
135membrane protein ectodomain proteolysis (GO:0006509)2.44321551
136positive regulation of NF-kappaB import into nucleus (GO:0042346)2.43899593
137positive regulation of osteoblast proliferation (GO:0033690)2.43350545
138sphingosine metabolic process (GO:0006670)2.43056608
139cortical actin cytoskeleton organization (GO:0030866)2.43005964
140regulation of nitric oxide biosynthetic process (GO:0045428)2.42925556
141regulation of inflammatory response to antigenic stimulus (GO:0002861)2.42577862
142pore complex assembly (GO:0046931)2.42495695
143positive regulation of natural killer cell activation (GO:0032816)2.40689533
144integrin-mediated signaling pathway (GO:0007229)2.40545767
145regulation of interferon-beta biosynthetic process (GO:0045357)2.39966339
146regulation of cholesterol storage (GO:0010885)2.38293983
147positive regulation of interleukin-12 production (GO:0032735)2.38084948
148positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.38041830
149positive regulation of nitric oxide biosynthetic process (GO:0045429)2.37950864
150defense response to protozoan (GO:0042832)2.37860596
151positive regulation of natural killer cell differentiation (GO:0032825)2.37538361
152granulocyte activation (GO:0036230)2.37015564
153extracellular matrix assembly (GO:0085029)2.36730490
154modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.36592128
155positive regulation by organism of defense response of other organism involved in symbiotic interact2.36592128
156modulation by symbiont of host immune response (GO:0052553)2.36592128
157positive regulation by symbiont of host defense response (GO:0052509)2.36592128
158modulation by symbiont of host defense response (GO:0052031)2.36592128
159modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.36592128
160response to muramyl dipeptide (GO:0032495)2.35141254
161regulation of antigen processing and presentation (GO:0002577)2.35109738
162positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.35041077
163osteoclast differentiation (GO:0030316)2.34001606
164positive regulation of lymphocyte migration (GO:2000403)2.33865450
165negative regulation of bone mineralization (GO:0030502)2.33862296
166positive regulation of monocyte chemotaxis (GO:0090026)2.32652870
167decidualization (GO:0046697)2.32581418
168regulation of necroptotic process (GO:0060544)2.32195629
169positive regulation of interferon-alpha production (GO:0032727)2.31016549
170sterol biosynthetic process (GO:0016126)2.30476305
171regulation of chemokine secretion (GO:0090196)2.29823966
172response to fungus (GO:0009620)2.29459232
173tyrosine phosphorylation of STAT protein (GO:0007260)2.28686926
174positive regulation of macrophage differentiation (GO:0045651)2.27702904
175negative regulation of biomineral tissue development (GO:0070168)2.24953942
176regulation of lymphocyte chemotaxis (GO:1901623)2.24920198
177sequestering of metal ion (GO:0051238)2.23893339
178cellular response to vitamin D (GO:0071305)2.23600952
179positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.23385809

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human4.95194721
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.29932914
3GATA1_22025678_ChIP-Seq_K562_Human4.03228205
4TP63_17297297_ChIP-ChIP_HaCaT_Human4.02485962
5IRF8_21731497_ChIP-ChIP_J774_Mouse3.84353168
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.80216241
7TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.74658917
8IRF8_22096565_ChIP-ChIP_GC-B_Human3.55285215
9TRIM28_21343339_ChIP-Seq_HEK293_Human3.12527661
10SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.99480343
11* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.99080852
12MYB_21317192_ChIP-Seq_ERMYB_Mouse2.97100112
13SCL_19346495_ChIP-Seq_HPC-7_Human2.90691704
14IRF8_27001747_Chip-Seq_BMDM_Mouse2.84135738
15* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.69902175
16IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.69387039
17* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.56156900
18Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.48202586
19SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.41568070
20CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.22676658
21ZNF263_19887448_ChIP-Seq_K562_Human2.18950370
22WT1_19549856_ChIP-ChIP_CCG9911_Human2.18092003
23* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.15058324
24SPI1_23547873_ChIP-Seq_NB4_Human1.97391210
25GATA2_21666600_ChIP-Seq_HMVEC_Human1.92030984
26CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.85756254
27STAT4_19710469_ChIP-ChIP_TH1__Mouse1.83974824
28* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.81870492
29STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.80322643
30CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.78008257
31SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.77648899
32SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.77648899
33* PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.77419845
34SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.77248415
35CLOCK_20551151_ChIP-Seq_293T_Human1.76743869
36PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.76008988
37IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.73783564
38E2F7_22180533_ChIP-Seq_HELA_Human1.73025014
39NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.71670848
40* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.71032890
41* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.70775729
42* SOX2_20726797_ChIP-Seq_SW620_Human1.69895720
43ELK1_19687146_ChIP-ChIP_HELA_Human1.65301959
44RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.63515431
45* CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.62654324
46* CJUN_26792858_Chip-Seq_BT549_Human1.57666916
47TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.56803637
48RUNX1_22412390_ChIP-Seq_EML_Mouse1.56496979
49* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.54594115
50* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.54594115
51* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.54590634
52RARG_19884340_ChIP-ChIP_MEFs_Mouse1.49877976
53VDR_24763502_ChIP-Seq_THP-1_Human1.46155683
54ELF1_17652178_ChIP-ChIP_JURKAT_Human1.43035951
55RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.43008570
56LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.40543819
57EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.34873581
58ERG_20887958_ChIP-Seq_HPC-7_Mouse1.33642366
59TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.33621141
60P63_26484246_Chip-Seq_KERATINOCYTES_Human1.32388043
61TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.32283567
62* PU_27001747_Chip-Seq_BMDM_Mouse1.31660630
63STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.30830961
64MYB_26560356_Chip-Seq_TH2_Human1.30039057
65* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.30012253
66AR_21909140_ChIP-Seq_LNCAP_Human1.28822672
67FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.28788794
68FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.26921507
69HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.25879650
70* NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.24916245
71EGR1_19374776_ChIP-ChIP_THP-1_Human1.23400369
72CDX2_19796622_ChIP-Seq_MESCs_Mouse1.22820463
73PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.22659562
74MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.21746131
75BRD4_25478319_ChIP-Seq_HGPS_Human1.21336810
76SALL4_18804426_ChIP-ChIP_XEN_Mouse1.16469719
77RUNX_20019798_ChIP-Seq_JUKART_Human1.15993881
78KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.15845225
79PPAR_26484153_Chip-Seq_NCI-H1993_Human1.13877184
80* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.13081159
81UBF1/2_26484160_Chip-Seq_HMECs_Human1.13036085
82VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.12598244
83FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.10850507
84STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.09819359
85ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.08035003
86* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.07244281
87VDR_24787735_ChIP-Seq_THP-1_Human1.06895702
88* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.06144374
89SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.06003655
90TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.05821330
91RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.05689885
92CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.05491130
93ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.05449561
94STAT3_1855785_ChIP-Seq_MESCs_Mouse1.05106734
95ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.04218622
96LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.03995292
97NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.02692409
98ELK3_25401928_ChIP-Seq_HUVEC_Human1.02444396
99MYB_26560356_Chip-Seq_TH1_Human1.02361214
100SPI1_23127762_ChIP-Seq_K562_Human1.01442477
101GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.00112920
102NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.99542571
103ELK1_22589737_ChIP-Seq_MCF10A_Human0.99332538
104KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.99283591
105FOXO3_23340844_ChIP-Seq_DLD1_Human0.99184403
106GATA1_22383799_ChIP-Seq_G1ME_Mouse0.98646564
107MYC_18555785_ChIP-Seq_MESCs_Mouse0.98517334
108TP53_18474530_ChIP-ChIP_U2OS_Human0.98047767
109TP53_16413492_ChIP-PET_HCT116_Human0.95504413
110ESR2_21235772_ChIP-Seq_MCF-7_Human0.94862417
111VDR_21846776_ChIP-Seq_THP-1_Human0.93797544
112EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.93212640
113PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.93022943
114PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.91623148
115HIF1A_21447827_ChIP-Seq_MCF-7_Human0.91565722
116GATA3_26560356_Chip-Seq_TH2_Human0.90619082
117HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.90459855
118NFI_21473784_ChIP-Seq_ESCs_Mouse0.89878107
119SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.87982776
120SMAD_19615063_ChIP-ChIP_OVARY_Human0.87520883
121CREB1_15753290_ChIP-ChIP_HEK293T_Human0.86964477
122CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.84556285
123CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.83948620
124PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.83900650
125TFEB_21752829_ChIP-Seq_HELA_Human0.83524037
126GATA1_19941826_ChIP-Seq_K562_Human0.83028813

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen4.61245209
2MP0003950_abnormal_plasma_membrane2.90042175
3* MP0002148_abnormal_hypersensitivity_rea2.51467433
4MP0008004_abnormal_stomach_pH2.45727318
5MP0006054_spinal_hemorrhage2.39737217
6MP0000920_abnormal_myelination2.39622550
7MP0005275_abnormal_skin_tensile2.39421354
8MP0002396_abnormal_hematopoietic_system2.38877997
9MP0005503_abnormal_tendon_morphology2.26818481
10MP0001835_abnormal_antigen_presentation2.25229620
11MP0005058_abnormal_lysosome_morphology2.19662378
12MP0003436_decreased_susceptibility_to2.19165554
13MP0003279_aneurysm2.10207738
14MP0003724_increased_susceptibility_to2.09989397
15MP0006082_CNS_inflammation2.09263540
16MP0000465_gastrointestinal_hemorrhage2.04848948
17* MP0002419_abnormal_innate_immunity2.02951932
18MP0001958_emphysema2.02137948
19MP0000685_abnormal_immune_system2.02075842
20MP0001533_abnormal_skeleton_physiology2.02019194
21MP0005464_abnormal_platelet_physiology2.01527305
22MP0009785_altered_susceptibility_to1.87149452
23MP0005023_abnormal_wound_healing1.87103316
24* MP0005000_abnormal_immune_tolerance1.85331371
25MP0001348_abnormal_lacrimal_gland1.75234378
26MP0000569_abnormal_digit_pigmentation1.71879728
27MP0005025_abnormal_response_to1.67379696
28MP0003656_abnormal_erythrocyte_physiolo1.63722471
29MP0003806_abnormal_nucleotide_metabolis1.62073421
30MP0009764_decreased_sensitivity_to1.58633318
31* MP0003075_altered_response_to1.57749582
32MP0010352_gastrointestinal_tract_polyps1.57054378
33MP0005390_skeleton_phenotype1.57018743
34MP0008260_abnormal_autophagy1.56355527
35MP0003566_abnormal_cell_adhesion1.55582851
36MP0010234_abnormal_vibrissa_follicle1.51687853
37MP0001851_eye_inflammation1.50984850
38MP0002933_joint_inflammation1.50867769
39MP0000343_altered_response_to1.49818443
40* MP0002452_abnormal_antigen_presenting1.49610235
41MP0005623_abnormal_meninges_morphology1.48572391
42MP0001790_abnormal_immune_system1.41748887
43MP0005387_immune_system_phenotype1.41748887
44MP0010155_abnormal_intestine_physiology1.41598788
45MP0000490_abnormal_crypts_of1.41003077
46MP0003705_abnormal_hypodermis_morpholog1.40845639
47MP0002295_abnormal_pulmonary_circulatio1.40581954
48MP0004808_abnormal_hematopoietic_stem1.39322611
49MP0001542_abnormal_bone_strength1.39012772
50MP0000383_abnormal_hair_follicle1.36555246
51MP0002060_abnormal_skin_morphology1.36346644
52MP0005257_abnormal_intraocular_pressure1.35477298
53MP0004272_abnormal_basement_membrane1.33713334
54MP0005508_abnormal_skeleton_morphology1.31754505
55MP0003300_gastrointestinal_ulcer1.31365820
56* MP0002723_abnormal_immune_serum1.30725632
57MP0010678_abnormal_skin_adnexa1.28762459
58MP0002998_abnormal_bone_remodeling1.26674012
59* MP0002420_abnormal_adaptive_immunity1.26669022
60* MP0001819_abnormal_immune_cell1.26381339
61MP0005671_abnormal_response_to1.25698949
62MP0003091_abnormal_cell_migration1.24214728
63MP0003448_altered_tumor_morphology1.22461065
64MP0001243_abnormal_dermal_layer1.21502506
65MP0002405_respiratory_system_inflammati1.20360529
66MP0001986_abnormal_taste_sensitivity1.17874838
67MP0003690_abnormal_glial_cell1.17563590
68MP0001800_abnormal_humoral_immune1.15235348
69MP0009278_abnormal_bone_marrow1.15038436
70MP0009384_cardiac_valve_regurgitation1.14746844
71MP0004947_skin_inflammation1.14623063
72* MP0005165_increased_susceptibility_to1.13737638
73MP0005397_hematopoietic_system_phenotyp1.11781514
74MP0001545_abnormal_hematopoietic_system1.11781514
75MP0002332_abnormal_exercise_endurance1.11449399
76MP0002877_abnormal_melanocyte_morpholog1.09594251
77MP0000579_abnormal_nail_morphology1.08393878
78MP0000372_irregular_coat_pigmentation1.07617606
79MP0005451_abnormal_body_composition1.07207389
80MP0003303_peritoneal_inflammation1.06687975
81MP0001216_abnormal_epidermal_layer1.06478322
82MP0000858_altered_metastatic_potential1.03472997
83MP0003186_abnormal_redox_activity1.03010685
84MP0003172_abnormal_lysosome_physiology1.02484497
85MP0003453_abnormal_keratinocyte_physiol1.01278125
86MP0000015_abnormal_ear_pigmentation1.01225632
87MP0009840_abnormal_foam_cell1.01049917
88MP0005171_absent_coat_pigmentation1.00725185
89MP0003795_abnormal_bone_structure1.00198822
90* MP0005166_decreased_susceptibility_to0.99539762
91MP0005167_abnormal_blood-brain_barrier0.98256922
92* MP0005164_abnormal_response_to0.98091739
93MP0002254_reproductive_system_inflammat0.96628021
94MP0001853_heart_inflammation0.96552183
95* MP0001845_abnormal_inflammatory_respons0.95614569
96MP0004134_abnormal_chest_morphology0.94839018
97MP0002166_altered_tumor_susceptibility0.93942207
98MP0000767_abnormal_smooth_muscle0.92656472
99MP0005666_abnormal_adipose_tissue0.92648076
100MP0002006_tumorigenesis0.92285607
101MP0009333_abnormal_splenocyte_physiolog0.90886906
102MP0003191_abnormal_cellular_cholesterol0.88864558
103MP0001849_ear_inflammation0.87304315
104MP0000733_abnormal_muscle_development0.86846091
105MP0002282_abnormal_trachea_morphology0.86713036
106MP0005174_abnormal_tail_pigmentation0.86577900
107* MP0000716_abnormal_immune_system0.85537185
108MP0001346_abnormal_lacrimal_gland0.80836108
109MP0002896_abnormal_bone_mineralization0.80529329
110MP0002398_abnormal_bone_marrow0.79749116
111MP0010307_abnormal_tumor_latency0.79090484
112* MP0008469_abnormal_protein_level0.78933899
113MP0001873_stomach_inflammation0.77992283
114MP0000371_diluted_coat_color0.77577778
115MP0002133_abnormal_respiratory_system0.76271516
116MP0005388_respiratory_system_phenotype0.76271516
117MP0009765_abnormal_xenobiotic_induced0.75976704
118MP0009250_abnormal_appendicular_skeleto0.74910525
119MP0003195_calcinosis0.74886475
120MP0002009_preneoplasia0.74312402
121MP0004147_increased_porphyrin_level0.73937867
122* MP0002429_abnormal_blood_cell0.73774857
123MP0009763_increased_sensitivity_to0.73730042
124MP0004233_abnormal_muscle_weight0.73545633
125MP0002113_abnormal_skeleton_development0.72689487
126MP0003828_pulmonary_edema0.72434752
127MP0005375_adipose_tissue_phenotype0.72180065
128MP0005621_abnormal_cell_physiology0.71434788
129MP0000689_abnormal_spleen_morphology0.70814917
130MP0001915_intracranial_hemorrhage0.70402741
131MP0000627_abnormal_mammary_gland0.69758158

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)5.45973110
2Abnormality of liposaccharide metabolism (HP:0010968)4.84884620
3Abnormality of glycosphingolipid metabolism (HP:0004343)4.84884620
4Abnormality of glycolipid metabolism (HP:0010969)4.84884620
5Osteolytic defects of the phalanges of the hand (HP:0009771)3.87209895
6Osteolytic defects of the hand bones (HP:0009699)3.87209895
7Protrusio acetabuli (HP:0003179)3.86718395
8Recurrent abscess formation (HP:0002722)3.70097007
9Parakeratosis (HP:0001036)3.63949909
10Peritonitis (HP:0002586)3.48426507
11Atrophic scars (HP:0001075)3.39666850
12Recurrent bacterial skin infections (HP:0005406)3.35800840
13Aortic dissection (HP:0002647)3.34303895
14Vertebral compression fractures (HP:0002953)3.26733643
15Petechiae (HP:0000967)3.20079264
16Increased neuronal autofluorescent lipopigment (HP:0002074)3.17942900
17Eczematoid dermatitis (HP:0000976)3.04579835
18Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.00932780
19Soft skin (HP:0000977)2.99409563
20Purpura (HP:0000979)2.94591897
21Onycholysis (HP:0001806)2.93955433
22Abnormality of macrophages (HP:0004311)2.88877910
23Syringomyelia (HP:0003396)2.86149943
24Spinal cord lesions (HP:0100561)2.86149943
25Mucopolysacchariduria (HP:0008155)2.84569895
26Urinary glycosaminoglycan excretion (HP:0003541)2.84569895
27Fragile skin (HP:0001030)2.82829752
28Cervical subluxation (HP:0003308)2.78805702
29Increased cerebral lipofuscin (HP:0011813)2.75417268
30Abnormality of glycosaminoglycan metabolism (HP:0004371)2.69509917
31Abnormality of mucopolysaccharide metabolism (HP:0011020)2.69509917
32Abnormality of polysaccharide metabolism (HP:0011012)2.69509917
33Vacuolated lymphocytes (HP:0001922)2.68186082
34Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.64229482
35Thrombocytosis (HP:0001894)2.60028963
36Wormian bones (HP:0002645)2.56081969
37Patchy hypopigmentation of hair (HP:0011365)2.55408575
38Systemic lupus erythematosus (HP:0002725)2.53208619
39Recurrent skin infections (HP:0001581)2.51337209
40Milia (HP:0001056)2.51085573
41Abnormal platelet volume (HP:0011876)2.50901991
42Glomerulonephritis (HP:0000099)2.45489248
43Elevated erythrocyte sedimentation rate (HP:0003565)2.41203400
44Myositis (HP:0100614)2.38873230
45White forelock (HP:0002211)2.35091035
46Autoimmune thrombocytopenia (HP:0001973)2.34587024
47Alopecia of scalp (HP:0002293)2.33276070
48Premature skin wrinkling (HP:0100678)2.29615348
49Plantar hyperkeratosis (HP:0007556)2.28206669
50Cellulitis (HP:0100658)2.27473209
51Spondylolisthesis (HP:0003302)2.26804114
52Hepatosplenomegaly (HP:0001433)2.23580987
53Increased mean platelet volume (HP:0011877)2.23579900
54Chronic otitis media (HP:0000389)2.23391121
55Stridor (HP:0010307)2.22374274
56Neonatal short-limb short stature (HP:0008921)2.22148783
57Myocardial infarction (HP:0001658)2.21908641
58Axonal loss (HP:0003447)2.21162356
59Disinhibition (HP:0000734)2.21049284
60Aortic aneurysm (HP:0004942)2.20792756
61Delayed cranial suture closure (HP:0000270)2.20314615
62Prolonged bleeding time (HP:0003010)2.17820884
63Delayed closure of the anterior fontanelle (HP:0001476)2.16653423
64Mitral stenosis (HP:0001718)2.13895824
65Thick nail (HP:0001805)2.12619489
66Prostate neoplasm (HP:0100787)2.12048714
67Periodontitis (HP:0000704)2.11522083
68Anhidrosis (HP:0000970)2.10752282
69Asymmetry of the thorax (HP:0001555)2.08526961
70Beaking of vertebral bodies (HP:0004568)2.08176699
71Blue sclerae (HP:0000592)2.07750488
72Broad face (HP:0000283)2.05721946
73Degeneration of the lateral corticospinal tracts (HP:0002314)2.05419672
74Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.05419672
75Recurrent viral infections (HP:0004429)2.03366047
76Neurofibrillary tangles (HP:0002185)2.03325154
77Fatigue (HP:0012378)2.03035994
78Shallow orbits (HP:0000586)2.02901518
79Interstitial pulmonary disease (HP:0006530)2.02896011
80Autoimmune hemolytic anemia (HP:0001890)2.02295316
81Abnormality of the vasculature of the conjunctiva (HP:0008054)2.02274488
82Infantile muscular hypotonia (HP:0008947)2.00785019
83Congenital ichthyosiform erythroderma (HP:0007431)2.00018682
84Keratoconjunctivitis sicca (HP:0001097)1.99559121
85Follicular hyperkeratosis (HP:0007502)1.97638701
86Ectropion (HP:0000656)1.97405139
87Autoamputation (HP:0001218)1.95747665
88Amyloidosis (HP:0011034)1.95616136
89Ulnar bowing (HP:0003031)1.95019285
90Basal ganglia calcification (HP:0002135)1.94142977
91Retrobulbar optic neuritis (HP:0100654)1.94125657
92Optic neuritis (HP:0100653)1.94125657
93Abnormality of the periventricular white matter (HP:0002518)1.93374734
94Ridged nail (HP:0001807)1.93229687
95Gingival bleeding (HP:0000225)1.92525051
96Nephritis (HP:0000123)1.91092145
97Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.89824463
98Absent frontal sinuses (HP:0002688)1.89070957
99Ankyloglossia (HP:0010296)1.88435564
100Asplenia (HP:0001746)1.88363891
101Aplasia cutis congenita (HP:0001057)1.88354810
102Vascular tortuosity (HP:0004948)1.88245574
103Orchitis (HP:0100796)1.88119728
104Abnormality of the 2nd finger (HP:0004100)1.88065200
105Mediastinal lymphadenopathy (HP:0100721)1.87953098
106Persistence of primary teeth (HP:0006335)1.87620648
107Abnormality of the frontal sinuses (HP:0002687)1.87340608
108Nuclear cataract (HP:0100018)1.86955376
109Abnormality of the lumbar spine (HP:0100712)1.86830902
110Obstructive lung disease (HP:0006536)1.86493196
111Chronic obstructive pulmonary disease (HP:0006510)1.86493196
112Osteomyelitis (HP:0002754)1.86448161
113Nonimmune hydrops fetalis (HP:0001790)1.85100412
114Femoral bowing (HP:0002980)1.85094832
115Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.84698898
116Tetraparesis (HP:0002273)1.84670788
117Gingivitis (HP:0000230)1.83827391
118Bruising susceptibility (HP:0000978)1.82353880
119Epistaxis (HP:0000421)1.82083027
120Pterygium (HP:0001059)1.81796752
121Spontaneous hematomas (HP:0007420)1.81315852
122Abnormality of the peritoneum (HP:0002585)1.80127626
123Albinism (HP:0001022)1.80094420
124Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.80029227
125Abnormality of dentin (HP:0010299)1.79805905
126Aplasia/Hypoplasia of the spleen (HP:0010451)1.79208593
127Recurrent lower respiratory tract infections (HP:0002783)1.79165653
128Neoplasm of head and neck (HP:0012288)1.78414040
129Esophageal neoplasm (HP:0100751)1.78414040
130Recurrent pneumonia (HP:0006532)1.78287423
131Upper motor neuron abnormality (HP:0002127)1.77510130
132Keratoconjunctivitis (HP:0001096)1.77079998
133Esophageal atresia (HP:0002032)1.76810274
134Abnormality of the basal ganglia (HP:0002134)1.75837342
135Short nail (HP:0001799)1.75222460
136Viral hepatitis (HP:0006562)1.75186449
137Ovoid vertebral bodies (HP:0003300)1.75139910
138Fragile nails (HP:0001808)1.75046540
139Biconcave vertebral bodies (HP:0004586)1.74508539
140Abnormal delivery (HP:0001787)1.74410506
141Increased density of long bones (HP:0006392)1.74259691
142J-shaped sella turcica (HP:0002680)1.74040433
143Dysostosis multiplex (HP:0000943)1.73572131
144Premature loss of primary teeth (HP:0006323)1.73362287
145Elbow flexion contracture (HP:0002987)1.72241736
146Ankle contracture (HP:0006466)1.72224856
147Dilatation of the ascending aorta (HP:0005111)1.72083541
148Increased serum ferritin (HP:0003281)1.71654316
149Abnormal blistering of the skin (HP:0008066)1.71186490
150Urticaria (HP:0001025)1.69945831
151Arterial tortuosity (HP:0005116)1.69801108
152Cheilitis (HP:0100825)1.69785944
153Cutaneous melanoma (HP:0012056)1.69412208
154Loss of speech (HP:0002371)1.69229741
155Nail dystrophy (HP:0008404)1.69082889
156Abnormality of oral frenula (HP:0000190)1.68312178
157Abnormality of iron homeostasis (HP:0011031)1.67298709

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHB13.71874921
2PBK3.47238488
3PDK23.43546828
4STK393.24428437
5MST1R2.85155120
6TRPM72.82321693
7KIT2.77102695
8BMPR22.55384811
9ERBB32.27735875
10PIM22.25109957
11ERN11.97324833
12IRAK41.90596420
13PRPF4B1.87359439
14TGFBR21.87265963
15CLK11.81317383
16TTN1.76659687
17SCYL21.75654425
18BLK1.74246490
19TESK21.73924602
20TEC1.70506424
21BTK1.66490903
22LIMK11.60070679
23OXSR11.57707425
24ARAF1.54324707
25NME21.53295824
26MET1.53290774
27MAP3K141.51988885
28DDR21.51253882
29MST41.50268939
30PIK3CG1.45194379
31JAK11.44676905
32CSF1R1.44512732
33RIPK11.42781124
34FER1.41588849
35MAP3K131.41030991
36PDGFRA1.40527955
37TBK11.40231365
38IKBKB1.39009944
39TESK11.33077117
40STK101.32948795
41TAOK21.30736092
42PIK3CA1.28799619
43PAK21.26859592
44TGFBR11.26614550
45LRRK21.21147778
46* MAPKAPK51.20391935
47JAK31.19577006
48IKBKE1.16479959
49NEK91.13064499
50NEK11.12028641
51BMPR1B1.10932560
52BCR1.10886103
53MAP2K31.10272638
54TYK21.09700192
55RIPK41.08821658
56MATK1.07314596
57CCNB11.07175652
58FGFR21.05064339
59FLT30.95236803
60EIF2AK10.94438658
61HCK0.93239475
62IRAK30.92865646
63MAPKAPK20.90909857
64LYN0.90909696
65LATS20.90587932
66CSK0.89714293
67MARK30.89382070
68MOS0.89057165
69LCK0.86652416
70STK40.84433501
71ITK0.83837081
72MYLK0.83456319
73CSNK1G30.83267000
74RPS6KA40.82084800
75NEK60.81075239
76STK30.77258926
77BRSK20.76841615
78CSNK1A1L0.76673207
79JAK20.76602419
80PAK40.76058042
81* RPS6KA50.73520548
82EPHA30.72854812
83NUAK10.72309414
84DMPK0.70036402
85ABL10.69448973
86FGR0.67462460
87TNK20.66014412
88RPS6KB20.65894705
89BMX0.65334627
90MAPKAPK30.63697507
91ZAP700.63509385
92MAP4K10.63045848
93STK160.62315507
94PTK20.60990249
95FRK0.59284827
96ACVR1B0.58726761
97VRK10.58665363
98PKN10.58469211
99GRK70.58246522
100PRKG20.57887229
101PDGFRB0.57365640
102SYK0.57194008
103PAK10.56591190
104ZAK0.56199525
105TXK0.55948082
106EIF2AK20.55751412
107CSNK1G10.55146376
108STK240.53305539
109BRAF0.53201962
110CDC70.52889398
111MAP3K30.51760429
112WNK40.51626572
113PTK60.51530679
114ROCK20.50776351
115CHUK0.49672323
116MAP3K80.49318609
117TIE10.48343357
118MAP3K50.47982627
119MAP3K60.47670874
120PIM10.47630259
121RAF10.47285911
122GSK3A0.47096126
123YES10.46322345
124ABL20.45693834
125CDC42BPA0.45516193
126PRKCQ0.45295535
127ADRBK20.44787802
128CDK60.44612981
129DAPK30.43713932
130WNK10.43260215
131BUB10.43013568
132FES0.41775940
133EGFR0.41702339
134MAP2K20.41643333
135EIF2AK30.40703399
136IRAK10.39672686
137MAP3K10.39665284
138FGFR30.37633056
139PRKAA20.37534760
140PDPK10.37521830
141IRAK20.37499323
142CAMKK20.34456346
143EEF2K0.30457234
144MAP3K120.30323118

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.99314276
2Steroid biosynthesis_Homo sapiens_hsa001002.80222301
3Malaria_Homo sapiens_hsa051442.38084679
4Pathogenic Escherichia coli infection_Homo sapiens_hsa051302.32583476
5Leishmaniasis_Homo sapiens_hsa051402.21094769
6Fatty acid elongation_Homo sapiens_hsa000622.18218170
7ECM-receptor interaction_Homo sapiens_hsa045121.93735914
8Protein export_Homo sapiens_hsa030601.88364757
9Sphingolipid metabolism_Homo sapiens_hsa006001.79736605
10Shigellosis_Homo sapiens_hsa051311.79027521
11Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.76496279
12Pertussis_Homo sapiens_hsa051331.74508756
13DNA replication_Homo sapiens_hsa030301.73697652
14Phagosome_Homo sapiens_hsa041451.53121614
15Salmonella infection_Homo sapiens_hsa051321.48931754
16Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.47040950
17Type I diabetes mellitus_Homo sapiens_hsa049401.42252100
18Lysosome_Homo sapiens_hsa041421.42247481
19Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.41257803
20Leukocyte transendothelial migration_Homo sapiens_hsa046701.39892136
21Rheumatoid arthritis_Homo sapiens_hsa053231.39277882
22Hematopoietic cell lineage_Homo sapiens_hsa046401.37699527
23Toll-like receptor signaling pathway_Homo sapiens_hsa046201.37185923
24NF-kappa B signaling pathway_Homo sapiens_hsa040641.36247929
25Ribosome_Homo sapiens_hsa030101.36205713
26* Arachidonic acid metabolism_Homo sapiens_hsa005901.35885828
27Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.33574598
28NOD-like receptor signaling pathway_Homo sapiens_hsa046211.32877004
29Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.32565020
30* Ether lipid metabolism_Homo sapiens_hsa005651.32010906
31Other glycan degradation_Homo sapiens_hsa005111.31642613
32* Platelet activation_Homo sapiens_hsa046111.30640121
33Galactose metabolism_Homo sapiens_hsa000521.26201902
34Osteoclast differentiation_Homo sapiens_hsa043801.25868652
35Legionellosis_Homo sapiens_hsa051341.25433740
36Toxoplasmosis_Homo sapiens_hsa051451.22199263
37Pentose phosphate pathway_Homo sapiens_hsa000301.18992779
38Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.18187830
39Focal adhesion_Homo sapiens_hsa045101.16597575
40Sulfur metabolism_Homo sapiens_hsa009201.16544727
41SNARE interactions in vesicular transport_Homo sapiens_hsa041301.15784375
42Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.14023132
43Glycosaminoglycan degradation_Homo sapiens_hsa005311.13556146
44Bladder cancer_Homo sapiens_hsa052191.13201476
45Small cell lung cancer_Homo sapiens_hsa052221.09497679
46Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.08520333
47Measles_Homo sapiens_hsa051621.05559599
48TNF signaling pathway_Homo sapiens_hsa046681.04847116
49Apoptosis_Homo sapiens_hsa042101.04400882
50Tuberculosis_Homo sapiens_hsa051521.03286673
51B cell receptor signaling pathway_Homo sapiens_hsa046621.02553664
52* Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.99422690
53Allograft rejection_Homo sapiens_hsa053300.98742811
54Staphylococcus aureus infection_Homo sapiens_hsa051500.98636575
55Regulation of actin cytoskeleton_Homo sapiens_hsa048100.97140008
56Antigen processing and presentation_Homo sapiens_hsa046120.96878044
57Asthma_Homo sapiens_hsa053100.96377258
58Amoebiasis_Homo sapiens_hsa051460.95429246
59Proteasome_Homo sapiens_hsa030500.95042992
60Glutathione metabolism_Homo sapiens_hsa004800.94236871
61Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.93142026
62p53 signaling pathway_Homo sapiens_hsa041150.93089093
63Base excision repair_Homo sapiens_hsa034100.90009995
64AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.89322171
65Nucleotide excision repair_Homo sapiens_hsa034200.89302002
66Jak-STAT signaling pathway_Homo sapiens_hsa046300.88915169
67Intestinal immune network for IgA production_Homo sapiens_hsa046720.88216430
68Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.88168742
69Proteoglycans in cancer_Homo sapiens_hsa052050.88069259
70Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.86327362
71Hepatitis B_Homo sapiens_hsa051610.85559469
72Mismatch repair_Homo sapiens_hsa034300.84510951
73Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.83340999
74Chemokine signaling pathway_Homo sapiens_hsa040620.82656623
75Histidine metabolism_Homo sapiens_hsa003400.82549484
76PI3K-Akt signaling pathway_Homo sapiens_hsa041510.82079389
77Viral carcinogenesis_Homo sapiens_hsa052030.81838862
78RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.80177626
79Sphingolipid signaling pathway_Homo sapiens_hsa040710.77815332
80Homologous recombination_Homo sapiens_hsa034400.76449281
81Herpes simplex infection_Homo sapiens_hsa051680.76110930
82Autoimmune thyroid disease_Homo sapiens_hsa053200.75155020
83Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.74253746
84Transcriptional misregulation in cancer_Homo sapiens_hsa052020.73589120
85Chronic myeloid leukemia_Homo sapiens_hsa052200.72876078
86Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.72713203
87Non-homologous end-joining_Homo sapiens_hsa034500.72557947
88Pancreatic cancer_Homo sapiens_hsa052120.71688378
89Influenza A_Homo sapiens_hsa051640.71442021
90N-Glycan biosynthesis_Homo sapiens_hsa005100.69549701
91MicroRNAs in cancer_Homo sapiens_hsa052060.69115455
92Graft-versus-host disease_Homo sapiens_hsa053320.68720607
93Complement and coagulation cascades_Homo sapiens_hsa046100.68548654
94Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.66362541
95Adipocytokine signaling pathway_Homo sapiens_hsa049200.65354867
96Acute myeloid leukemia_Homo sapiens_hsa052210.63530576
97Systemic lupus erythematosus_Homo sapiens_hsa053220.61530975
98HIF-1 signaling pathway_Homo sapiens_hsa040660.59590893
99Viral myocarditis_Homo sapiens_hsa054160.58933341
100Cell cycle_Homo sapiens_hsa041100.58786447
101Prion diseases_Homo sapiens_hsa050200.58706501
102Hepatitis C_Homo sapiens_hsa051600.58256599
103Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.55008728
104TGF-beta signaling pathway_Homo sapiens_hsa043500.51944869
105Pathways in cancer_Homo sapiens_hsa052000.49759414
106Renal cell carcinoma_Homo sapiens_hsa052110.49695835
107Endocytosis_Homo sapiens_hsa041440.49275733
108Epstein-Barr virus infection_Homo sapiens_hsa051690.47266521
109Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.47022871
110Melanoma_Homo sapiens_hsa052180.46963527
111Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.46597747
112Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.46328294
113African trypanosomiasis_Homo sapiens_hsa051430.44167039
114Prostate cancer_Homo sapiens_hsa052150.43265720
115Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.42692371
116Renin-angiotensin system_Homo sapiens_hsa046140.42108840
117Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.40355680
118Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.40107421
119HTLV-I infection_Homo sapiens_hsa051660.38346680
120PPAR signaling pathway_Homo sapiens_hsa033200.35869423
121Carbon metabolism_Homo sapiens_hsa012000.31572929
122Prolactin signaling pathway_Homo sapiens_hsa049170.30341936
123Fatty acid biosynthesis_Homo sapiens_hsa000610.28089296
124Central carbon metabolism in cancer_Homo sapiens_hsa052300.26510655
125Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.26257945

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