PLA2G4B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the cytosolic phospholipase A2 protein family. Phospholipase A2 enzymes hydrolyze the sn-2 bond of phospholipids, releasing lysophospholipids and fatty acids. This enzyme may be associated with mitochondria and early endosomes. Most tissues also express read-through transcripts from the upstream gene into this gene, some of which may encode fusion proteins combining the N-terminus of the upstream gene including its JmjC domain with the almost complete coding region of this gene, including the C2 and cytoplasmic phospholipase A2 domains. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)8.35597810
2central nervous system myelination (GO:0022010)8.35597810
3keratinization (GO:0031424)6.11805143
4fatty acid elongation (GO:0030497)5.84805498
5long-chain fatty acid biosynthetic process (GO:0042759)5.75858860
6myelination (GO:0042552)5.26842399
7behavioral response to nicotine (GO:0035095)5.24196902
8ensheathment of neurons (GO:0007272)5.20812955
9axon ensheathment (GO:0008366)5.20812955
10presynaptic membrane assembly (GO:0097105)5.13311409
11presynaptic membrane organization (GO:0097090)4.79815847
12positive regulation of action potential (GO:0045760)4.73922400
13neuron cell-cell adhesion (GO:0007158)4.62127289
14negative regulation of neurotransmitter secretion (GO:0046929)4.34308892
15transmission of nerve impulse (GO:0019226)4.26287101
16positive regulation of growth hormone secretion (GO:0060124)4.22426429
17cholesterol biosynthetic process (GO:0006695)4.15008176
18oligodendrocyte differentiation (GO:0048709)4.13523132
19negative regulation of neurotransmitter transport (GO:0051589)4.03506853
20negative regulation of protein localization to cell surface (GO:2000009)4.00777448
21pyrimidine nucleobase catabolic process (GO:0006208)3.89655250
22regulation of collateral sprouting (GO:0048670)3.84515143
23mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.74869128
24limb bud formation (GO:0060174)3.71117076
25isoprenoid biosynthetic process (GO:0008299)3.70461877
26L-amino acid import (GO:0043092)3.69726746
27positive regulation of protein homodimerization activity (GO:0090073)3.63523803
28substantia nigra development (GO:0021762)3.63523178
29cerebral cortex radially oriented cell migration (GO:0021799)3.57239578
30sterol biosynthetic process (GO:0016126)3.57122673
31negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.56734718
32dendritic spine morphogenesis (GO:0060997)3.48946263
33regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.43483073
34chaperone-mediated protein transport (GO:0072321)3.43412799
35response to redox state (GO:0051775)3.42831755
36neuron remodeling (GO:0016322)3.41706113
37synaptic transmission, cholinergic (GO:0007271)3.35445011
38negative regulation of axon extension (GO:0030517)3.32952404
39epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.32109020
40protein neddylation (GO:0045116)3.29273387
41nucleobase catabolic process (GO:0046113)3.25762666
42phosphatidylinositol acyl-chain remodeling (GO:0036149)3.25682464
43negative regulation of telomere maintenance (GO:0032205)3.25322519
44photoreceptor cell differentiation (GO:0046530)3.20586314
45eye photoreceptor cell differentiation (GO:0001754)3.20586314
46fucose catabolic process (GO:0019317)3.17126031
47L-fucose metabolic process (GO:0042354)3.17126031
48L-fucose catabolic process (GO:0042355)3.17126031
49axoneme assembly (GO:0035082)3.15940618
50nucleotide transmembrane transport (GO:1901679)3.12427196
51mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.12261252
52* glycerophospholipid catabolic process (GO:0046475)3.09564486
53establishment of skin barrier (GO:0061436)3.08807905
54substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.08229895
55substrate-independent telencephalic tangential migration (GO:0021826)3.08229895
56cellular response to epinephrine stimulus (GO:0071872)3.06489723
57regulation of microtubule-based movement (GO:0060632)3.06029623
58neuron recognition (GO:0008038)3.04264337
59cerebellar granule cell differentiation (GO:0021707)3.01426212
60membrane assembly (GO:0071709)2.99945838
61negative regulation of synaptic transmission, GABAergic (GO:0032229)2.98242021
62adult walking behavior (GO:0007628)2.97163043
63ATP synthesis coupled proton transport (GO:0015986)2.96418047
64energy coupled proton transport, down electrochemical gradient (GO:0015985)2.96418047
65astrocyte development (GO:0014002)2.95998113
66activated T cell proliferation (GO:0050798)2.95312020
67negative regulation of axonogenesis (GO:0050771)2.92962530
68ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.92765061
69gamma-aminobutyric acid signaling pathway (GO:0007214)2.91153530
70GPI anchor biosynthetic process (GO:0006506)2.90463910
71growth hormone secretion (GO:0030252)2.90345374
72histone H2B ubiquitination (GO:0033523)2.89993226
73positive regulation of synapse assembly (GO:0051965)2.89936327
74regulation of cilium movement (GO:0003352)2.89924252
75neuronal ion channel clustering (GO:0045161)2.89161740
76neural nucleus development (GO:0048857)2.84985373
77neurotransmitter uptake (GO:0001504)2.84247855
78epithelial cilium movement (GO:0003351)2.83761577
79protein localization to cilium (GO:0061512)2.83563793
80regulation of catecholamine metabolic process (GO:0042069)2.83255240
81regulation of dopamine metabolic process (GO:0042053)2.83255240
82GPI anchor metabolic process (GO:0006505)2.83043156
83dopamine biosynthetic process (GO:0042416)2.82964771
84neuronal action potential propagation (GO:0019227)2.82738364
85amino acid import (GO:0043090)2.82451619
86molting cycle (GO:0042303)2.82273178
87hair cycle (GO:0042633)2.82273178
88preassembly of GPI anchor in ER membrane (GO:0016254)2.80855083
89nonmotile primary cilium assembly (GO:0035058)2.80683480
90adhesion of symbiont to host cell (GO:0044650)2.79058323
91virion attachment to host cell (GO:0019062)2.79058323
92response to epinephrine (GO:0071871)2.76870221
93positive regulation of oligodendrocyte differentiation (GO:0048714)2.73617085
94amyloid precursor protein metabolic process (GO:0042982)2.73041521
95cranial nerve development (GO:0021545)2.71610286
96import into cell (GO:0098657)2.68323431
97protein palmitoylation (GO:0018345)2.67736160
98peripheral nervous system development (GO:0007422)2.63991566
99mannosylation (GO:0097502)2.63897079
100ionotropic glutamate receptor signaling pathway (GO:0035235)2.63805305
101gamma-aminobutyric acid transport (GO:0015812)2.63239771
102respiratory electron transport chain (GO:0022904)2.63052500
103arginine catabolic process (GO:0006527)2.62517156
104cellular response to hepatocyte growth factor stimulus (GO:0035729)2.61860785
105response to hepatocyte growth factor (GO:0035728)2.61860785
106axonal fasciculation (GO:0007413)2.61243214
107myelination in peripheral nervous system (GO:0022011)2.60492874
108peripheral nervous system axon ensheathment (GO:0032292)2.60492874
109* phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.59131885
110righting reflex (GO:0060013)2.59111747
111opioid receptor signaling pathway (GO:0038003)2.59055804
112negative regulation of execution phase of apoptosis (GO:1900118)2.57978949
113protein polyglutamylation (GO:0018095)2.57600587
114RNA destabilization (GO:0050779)2.56457359
115head development (GO:0060322)2.55973211
116glutamate receptor signaling pathway (GO:0007215)2.55870852
117electron transport chain (GO:0022900)2.54816721
118regulation of growth hormone secretion (GO:0060123)2.54173858
119regulation of neuron projection regeneration (GO:0070570)2.54007610
120regulation of axon regeneration (GO:0048679)2.54007610
121detection of light stimulus involved in sensory perception (GO:0050962)2.52687798
122detection of light stimulus involved in visual perception (GO:0050908)2.52687798
123negative regulation of cAMP-mediated signaling (GO:0043951)2.51650152
124establishment of mitochondrion localization (GO:0051654)2.51554960
125detection of bacterium (GO:0016045)2.51298895
126postsynaptic membrane organization (GO:0001941)2.51285617
127viral transcription (GO:0019083)2.51253833
128magnesium ion transport (GO:0015693)2.50624539
129negative regulation of exocytosis (GO:0045920)2.50435353
130myelin maintenance (GO:0043217)2.50096974
131cell proliferation in forebrain (GO:0021846)2.48716045
132membrane depolarization during action potential (GO:0086010)2.47451705
133detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.47386077
134asymmetric protein localization (GO:0008105)2.47060027
135lateral sprouting from an epithelium (GO:0060601)2.46019706
136startle response (GO:0001964)2.45610947
137positive regulation of Notch signaling pathway (GO:0045747)2.44960961
138peptidyl-tyrosine autophosphorylation (GO:0038083)2.44119513
139positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)2.43073165
140synaptic transmission, glutamatergic (GO:0035249)2.42685142
141forebrain morphogenesis (GO:0048853)2.42057522
142retina layer formation (GO:0010842)2.41704233
143positive regulation of cellular amine metabolic process (GO:0033240)2.41656350
144organ growth (GO:0035265)2.40832495
145neuron-neuron synaptic transmission (GO:0007270)2.39965855
146interferon-gamma production (GO:0032609)2.38448112
147cell migration in hindbrain (GO:0021535)2.38149411
148nephron tubule morphogenesis (GO:0072078)2.37612374
149nephron epithelium morphogenesis (GO:0072088)2.37612374
150keratinocyte differentiation (GO:0030216)2.36615586
151* phosphatidylserine acyl-chain remodeling (GO:0036150)2.36245974
152negative regulation of interleukin-1 production (GO:0032692)2.36062876
153somite development (GO:0061053)2.35950752
154adaptation of signaling pathway (GO:0023058)2.35402307
155retinal ganglion cell axon guidance (GO:0031290)2.34675633
156cilium movement (GO:0003341)2.33352219
157tyrosine phosphorylation of STAT protein (GO:0007260)2.32993902
158negative regulation of mast cell activation (GO:0033004)2.32091450
159membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.32059737
160positive regulation of CREB transcription factor activity (GO:0032793)2.30906703
161indole-containing compound catabolic process (GO:0042436)2.30023586
162indolalkylamine catabolic process (GO:0046218)2.30023586
163tryptophan catabolic process (GO:0006569)2.30023586
164response to pheromone (GO:0019236)2.29567019
165spinal cord association neuron differentiation (GO:0021527)2.28923220
166cornea development in camera-type eye (GO:0061303)2.28773797
167forebrain neuron differentiation (GO:0021879)2.28586733
168negative regulation of cell killing (GO:0031342)2.27473300
169negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.27473300
170translational termination (GO:0006415)2.27362764
171neuronal action potential (GO:0019228)2.26867914
172regulation of action potential (GO:0098900)2.26507270
173indolalkylamine metabolic process (GO:0006586)2.24610163
174positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.24119041
175* phosphatidylcholine acyl-chain remodeling (GO:0036151)2.23058987
176positive regulation of defense response to virus by host (GO:0002230)2.22127809
177photoreceptor cell maintenance (GO:0045494)2.22122352
178defense response to fungus (GO:0050832)2.20942914
179negative regulation of interleukin-1 beta production (GO:0032691)2.20802409
180telencephalon development (GO:0021537)2.18433444
181regulation of water loss via skin (GO:0033561)2.13479845
182mechanosensory behavior (GO:0007638)2.13319896
183detection of other organism (GO:0098543)2.12875670
184viral protein processing (GO:0019082)2.12575924

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human3.84312785
2EZH2_22144423_ChIP-Seq_EOC_Human3.81083206
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.40701696
4TAF15_26573619_Chip-Seq_HEK293_Human3.22638776
5SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.19393873
6ZNF274_21170338_ChIP-Seq_K562_Hela2.67986743
7JARID2_20064375_ChIP-Seq_MESCs_Mouse2.56117977
8ZFP57_27257070_Chip-Seq_ESCs_Mouse2.51083276
9SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.49124325
10EZH2_27304074_Chip-Seq_ESCs_Mouse2.44999540
11SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.40858925
12EED_16625203_ChIP-ChIP_MESCs_Mouse2.33618178
13IKZF1_21737484_ChIP-ChIP_HCT116_Human2.33537285
14CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.26710121
15BMI1_23680149_ChIP-Seq_NPCS_Mouse2.24445725
16GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.18511755
17VDR_22108803_ChIP-Seq_LS180_Human2.16265160
18SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.14362229
19CBX2_27304074_Chip-Seq_ESCs_Mouse2.11549056
20CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.10647455
21SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.10491589
22POU3F2_20337985_ChIP-ChIP_501MEL_Human2.09114016
23SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.08282861
24SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.02858267
25RNF2_18974828_ChIP-Seq_MESCs_Mouse2.02628793
26EZH2_18974828_ChIP-Seq_MESCs_Mouse2.02628793
27CTBP1_25329375_ChIP-Seq_LNCAP_Human1.99404366
28FUS_26573619_Chip-Seq_HEK293_Human1.93844094
29TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.93064018
30ER_23166858_ChIP-Seq_MCF-7_Human1.92446552
31JARID2_20075857_ChIP-Seq_MESCs_Mouse1.91982343
32CTBP2_25329375_ChIP-Seq_LNCAP_Human1.85423977
33EZH2_27294783_Chip-Seq_ESCs_Mouse1.82164964
34P300_19829295_ChIP-Seq_ESCs_Human1.79126863
35E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.79065109
36OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.77145043
37MTF2_20144788_ChIP-Seq_MESCs_Mouse1.77015759
38SUZ12_27294783_Chip-Seq_ESCs_Mouse1.75996467
39CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.74374144
40PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.73882063
41PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.72706979
42SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.71489331
43ETV2_25802403_ChIP-Seq_MESCs_Mouse1.71249794
44AR_21572438_ChIP-Seq_LNCaP_Human1.69673278
45RNF2_27304074_Chip-Seq_ESCs_Mouse1.67264238
46CTCF_27219007_Chip-Seq_Bcells_Human1.62785113
47CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.62463583
48RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.61635831
49RNF2_27304074_Chip-Seq_NSC_Mouse1.61615394
50SMAD3_21741376_ChIP-Seq_EPCs_Human1.60529281
51EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.56031448
52ERA_21632823_ChIP-Seq_H3396_Human1.46892589
53REST_21632747_ChIP-Seq_MESCs_Mouse1.43407583
54PCGF2_27294783_Chip-Seq_ESCs_Mouse1.42752361
55BCL6_27268052_Chip-Seq_Bcells_Human1.41774414
56* NANOG_18555785_Chip-Seq_ESCs_Mouse1.40815491
57POU5F1_16153702_ChIP-ChIP_HESCs_Human1.40701779
58LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.40042998
59GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.39800894
60CDX2_19796622_ChIP-Seq_MESCs_Mouse1.38328887
61TAF2_19829295_ChIP-Seq_ESCs_Human1.38314203
62PIAS1_25552417_ChIP-Seq_VCAP_Human1.37410520
63WT1_19549856_ChIP-ChIP_CCG9911_Human1.37161923
64SMAD4_21799915_ChIP-Seq_A2780_Human1.36090776
65* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.36025780
66NANOG_20526341_ChIP-Seq_ESCs_Human1.35232368
67FLI1_27457419_Chip-Seq_LIVER_Mouse1.34415100
68IRF1_19129219_ChIP-ChIP_H3396_Human1.34126770
69GATA3_21878914_ChIP-Seq_MCF-7_Human1.33837790
70RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.33741357
71TOP2B_26459242_ChIP-Seq_MCF-7_Human1.33480069
72* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.32575811
73UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.32476946
74DROSHA_22980978_ChIP-Seq_HELA_Human1.32144374
75E2F1_20622854_ChIP-Seq_HELA_Human1.31749719
76* NCOR_22424771_ChIP-Seq_293T_Human1.29795797
77TAL1_26923725_Chip-Seq_HPCs_Mouse1.29494554
78* CMYC_18555785_Chip-Seq_ESCs_Mouse1.28983738
79* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.28171372
80* P300_18555785_Chip-Seq_ESCs_Mouse1.26668916
81PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.26349197
82SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.25756638
83POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.24303097
84TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24303097
85P68_20966046_ChIP-Seq_HELA_Human1.24278073
86DNAJC2_21179169_ChIP-ChIP_NT2_Human1.24158426
87TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22849793
88SUZ12_27294783_Chip-Seq_NPCs_Mouse1.22709939
89EWS_26573619_Chip-Seq_HEK293_Human1.22022597
90OCT4_20526341_ChIP-Seq_ESCs_Human1.21176541
91* E2F1_18555785_Chip-Seq_ESCs_Mouse1.21130305
92SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.20830937
93* P53_22387025_ChIP-Seq_ESCs_Mouse1.20442630
94CTCF_20526341_ChIP-Seq_ESCs_Human1.20376249
95* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.18004570
96PCGF2_27294783_Chip-Seq_NPCs_Mouse1.17427516
97YY1_22570637_ChIP-Seq_MALME-3M_Human1.17266372
98MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.16454591
99* MYC_19829295_ChIP-Seq_ESCs_Human1.15868742
100GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.15588762
101OCT4_19829295_ChIP-Seq_ESCs_Human1.15453625
102RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.15150516
103RUNX1_27457419_Chip-Seq_LIVER_Mouse1.15120868
104* STAT3_18555785_Chip-Seq_ESCs_Mouse1.14602433
105NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.14451603
106RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.12400912
107STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.12309622
108BCOR_27268052_Chip-Seq_Bcells_Human1.12215874
109RUNX2_22187159_ChIP-Seq_PCA_Human1.12110404
110EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.12103822
111MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.11535803
112BCAT_22108803_ChIP-Seq_LS180_Human1.11529031
113PHF8_20622854_ChIP-Seq_HELA_Human1.11084346
114CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.10140392
115TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.09606675
116P53_22127205_ChIP-Seq_FIBROBLAST_Human1.09569401
117BP1_19119308_ChIP-ChIP_Hs578T_Human1.08906950
118PRDM14_20953172_ChIP-Seq_ESCs_Human1.08547836
119THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.08523099
120TP53_22573176_ChIP-Seq_HFKS_Human1.07199665
121SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.07195854
122EZH2_27294783_Chip-Seq_NPCs_Mouse1.06636065
123RING1B_27294783_Chip-Seq_ESCs_Mouse1.06609763
124CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06604320
125IGF1R_20145208_ChIP-Seq_DFB_Human1.06316081
126VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.06277764
127TCF4_23295773_ChIP-Seq_U87_Human1.06195724
128* SOX2_18555785_Chip-Seq_ESCs_Mouse1.05716398
129RAC3_21632823_ChIP-Seq_H3396_Human1.05448170
130JUN_21703547_ChIP-Seq_K562_Human1.04485587
131AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.04407138
132* KLF4_18555785_Chip-Seq_ESCs_Mouse1.04381076
133ERG_21242973_ChIP-ChIP_JURKAT_Human1.04195352
134STAT3_23295773_ChIP-Seq_U87_Human1.04186132
135MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.02736688
136FOXH1_21741376_ChIP-Seq_ESCs_Human1.02382009
137TP53_18474530_ChIP-ChIP_U2OS_Human1.02292318
138RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human1.02106016
139STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.01845702
140* SMAD1_18555785_Chip-Seq_ESCs_Mouse1.01698501
141NFE2_27457419_Chip-Seq_LIVER_Mouse1.01637782
142GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01536332
143SA1_27219007_Chip-Seq_Bcells_Human1.01334265
144EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.00981327
145* NMYC_18555785_Chip-Seq_ESCs_Mouse1.00346190
146RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.00159552
147REST_18959480_ChIP-ChIP_MESCs_Mouse0.99240614
148* TP63_22573176_ChIP-Seq_HFKS_Human0.99065976
149* OCT4_18555785_Chip-Seq_ESCs_Mouse0.98349747
150HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.98277682
151FOXA1_25329375_ChIP-Seq_VCAP_Human0.97712058
152FOXA1_27270436_Chip-Seq_PROSTATE_Human0.97712058
153P300_27268052_Chip-Seq_Bcells_Human0.97502208
154IRF8_22096565_ChIP-ChIP_GC-B_Human0.96946920
155SMC4_20622854_ChIP-Seq_HELA_Human0.96939692
156SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.94192551
157CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.94073172
158P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.89778251
159ELF1_20517297_ChIP-Seq_JURKAT_Human0.89491864
160HOXB7_26014856_ChIP-Seq_BT474_Human0.89398378
161WDR5_24793694_ChIP-Seq_LNCAP_Human0.88831891
162VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.88691648
163SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.88518700
164P53_21459846_ChIP-Seq_SAOS-2_Human0.87456357
165AR_25329375_ChIP-Seq_VCAP_Human0.86234998
166BCL6_25482012_ChIP-Seq_CML-JURL-MK1_Human0.85189930
167OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.84686510

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern5.38371803
2MP0000920_abnormal_myelination3.46066786
3MP0005409_darkened_coat_color3.44080648
4MP0001529_abnormal_vocalization3.16432236
5MP0002653_abnormal_ependyma_morphology2.99102009
6MP0003136_yellow_coat_color2.91027135
7MP0005171_absent_coat_pigmentation2.81644344
8MP0004270_analgesia2.78928693
9MP0003878_abnormal_ear_physiology2.73792185
10MP0005377_hearing/vestibular/ear_phenot2.73792185
11MP0001905_abnormal_dopamine_level2.61466565
12MP0004742_abnormal_vestibular_system2.43026273
13MP0002272_abnormal_nervous_system2.41250316
14MP0001486_abnormal_startle_reflex2.37461832
15MP0006276_abnormal_autonomic_nervous2.34806297
16MP0002064_seizures2.34597362
17MP0000778_abnormal_nervous_system2.32367638
18MP0004142_abnormal_muscle_tone2.27211085
19MP0009745_abnormal_behavioral_response2.23258287
20MP0003011_delayed_dark_adaptation2.22512659
21MP0009046_muscle_twitch2.03702379
22MP0001440_abnormal_grooming_behavior2.01701707
23MP0001188_hyperpigmentation1.99713934
24MP0003635_abnormal_synaptic_transmissio1.98836981
25MP0003690_abnormal_glial_cell1.96685378
26MP0000566_synostosis1.93341888
27MP0004885_abnormal_endolymph1.91671305
28MP0008877_abnormal_DNA_methylation1.87702142
29MP0002735_abnormal_chemical_nociception1.87640247
30MP0004859_abnormal_synaptic_plasticity1.87362191
31MP0005423_abnormal_somatic_nervous1.86666290
32MP0002796_impaired_skin_barrier1.84165994
33MP0001485_abnormal_pinna_reflex1.82641773
34MP0002734_abnormal_mechanical_nocicepti1.81282918
35MP0002572_abnormal_emotion/affect_behav1.80545190
36MP0003123_paternal_imprinting1.77422263
37MP0004381_abnormal_hair_follicle1.71828577
38MP0001968_abnormal_touch/_nociception1.68630701
39MP0003329_amyloid_beta_deposits1.64140974
40MP0002163_abnormal_gland_morphology1.61087777
41MP0005551_abnormal_eye_electrophysiolog1.60353648
42MP0000579_abnormal_nail_morphology1.59134060
43MP0002063_abnormal_learning/memory/cond1.57268334
44MP0002736_abnormal_nociception_after1.54013394
45MP0002067_abnormal_sensory_capabilities1.52571965
46MP0005451_abnormal_body_composition1.52563888
47MP0003634_abnormal_glial_cell1.50081888
48MP0002638_abnormal_pupillary_reflex1.46332179
49MP0001970_abnormal_pain_threshold1.44424317
50MP0003632_abnormal_nervous_system1.43546890
51MP0002928_abnormal_bile_duct1.42340160
52MP0006292_abnormal_olfactory_placode1.41277100
53MP0002733_abnormal_thermal_nociception1.41190797
54MP0000462_abnormal_digestive_system1.40491358
55MP0003950_abnormal_plasma_membrane1.39785490
56MP0002229_neurodegeneration1.38877241
57MP0005386_behavior/neurological_phenoty1.38519637
58MP0004924_abnormal_behavior1.38519637
59MP0005671_abnormal_response_to1.33176631
60MP0002882_abnormal_neuron_morphology1.32889499
61MP0003121_genomic_imprinting1.30489311
62MP0005410_abnormal_fertilization1.30304271
63MP0001963_abnormal_hearing_physiology1.28417864
64MP0004043_abnormal_pH_regulation1.27580379
65MP0000427_abnormal_hair_cycle1.26533095
66MP0003938_abnormal_ear_development1.25459126
67MP0001501_abnormal_sleep_pattern1.24452736
68MP0002184_abnormal_innervation1.23982441
69MP0000955_abnormal_spinal_cord1.23286063
70MP0004133_heterotaxia1.22633446
71MP0002752_abnormal_somatic_nervous1.22037499
72MP0002095_abnormal_skin_pigmentation1.20116278
73MP0008789_abnormal_olfactory_epithelium1.19098694
74MP0009379_abnormal_foot_pigmentation1.17860484
75MP0001984_abnormal_olfaction1.17380896
76MP0005075_abnormal_melanosome_morpholog1.17134705
77MP0002557_abnormal_social/conspecific_i1.16465068
78MP0000026_abnormal_inner_ear1.15521772
79MP0002066_abnormal_motor_capabilities/c1.15345329
80MP0008995_early_reproductive_senescence1.15336382
81MP0005499_abnormal_olfactory_system1.12813995
82MP0005394_taste/olfaction_phenotype1.12813995
83MP0008569_lethality_at_weaning1.11462181
84MP0010386_abnormal_urinary_bladder1.09780527
85MP0002138_abnormal_hepatobiliary_system1.09469387
86MP0002876_abnormal_thyroid_physiology1.09290822
87MP0006072_abnormal_retinal_apoptosis1.08297407
88MP0008872_abnormal_physiological_respon1.05009334
89MP0000383_abnormal_hair_follicle1.04408624
90MP0008875_abnormal_xenobiotic_pharmacok1.03888960
91MP0005253_abnormal_eye_physiology1.02864959
92MP0005167_abnormal_blood-brain_barrier1.02458161
93MP0002102_abnormal_ear_morphology1.00926534
94MP0003879_abnormal_hair_cell0.99814285
95MP0005645_abnormal_hypothalamus_physiol0.99220262
96MP0003631_nervous_system_phenotype0.97868168
97MP0002160_abnormal_reproductive_system0.94536343
98MP0002822_catalepsy0.93362213
99MP0005084_abnormal_gallbladder_morpholo0.93286221
100MP0000631_abnormal_neuroendocrine_gland0.93062784
101MP0001346_abnormal_lacrimal_gland0.92892276
102MP0002938_white_spotting0.91920938
103MP0005389_reproductive_system_phenotype0.91721131
104MP0005448_abnormal_energy_balance0.91608112
105MP0005379_endocrine/exocrine_gland_phen0.90493182
106MP0005195_abnormal_posterior_eye0.89423911
107MP0005408_hypopigmentation0.88849459
108MP0004134_abnormal_chest_morphology0.88661745
109MP0002277_abnormal_respiratory_mucosa0.88280832
110MP0000762_abnormal_tongue_morphology0.88136391
111MP0002249_abnormal_larynx_morphology0.88015059
112MP0000372_irregular_coat_pigmentation0.87517137
113MP0001502_abnormal_circadian_rhythm0.85431930
114MP0001986_abnormal_taste_sensitivity0.84291791
115MP0000647_abnormal_sebaceous_gland0.84110393
116MP0003646_muscle_fatigue0.82597371
117MP0001177_atelectasis0.82104554
118MP0001800_abnormal_humoral_immune0.80410371
119MP0002152_abnormal_brain_morphology0.79856466
120MP0003937_abnormal_limbs/digits/tail_de0.79819387
121MP0001790_abnormal_immune_system0.79327808
122MP0005387_immune_system_phenotype0.79327808
123MP0008057_abnormal_DNA_replication0.79124221
124MP0004145_abnormal_muscle_electrophysio0.78860175
125MP0009250_abnormal_appendicular_skeleto0.77683372
126MP0000569_abnormal_digit_pigmentation0.77270122
127MP0005174_abnormal_tail_pigmentation0.77085379
128MP0001299_abnormal_eye_distance/0.76652631
129MP0003122_maternal_imprinting0.76589306
130MP0005535_abnormal_body_temperature0.76188940
131MP0001661_extended_life_span0.74845369
132MP0005646_abnormal_pituitary_gland0.74418365
133MP0002751_abnormal_autonomic_nervous0.72758883
134MP0000015_abnormal_ear_pigmentation0.69956383
135MP0001727_abnormal_embryo_implantation0.68844054
136MP0003633_abnormal_nervous_system0.66145041
137MP0003787_abnormal_imprinting0.65847597
138MP0010678_abnormal_skin_adnexa0.63886362
139MP0003137_abnormal_impulse_conducting0.63402162

Predicted human phenotypes

RankGene SetZ-score
1Degeneration of the lateral corticospinal tracts (HP:0002314)5.01678273
2Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)5.01678273
3Parakeratosis (HP:0001036)4.87123247
4Neurofibrillary tangles (HP:0002185)4.40092187
5Abnormality of nail color (HP:0100643)4.14239386
6Congenital nonbullous ichthyosiform erythroderma (HP:0007479)4.10508551
7Sensory axonal neuropathy (HP:0003390)3.87224707
8Congenital stationary night blindness (HP:0007642)3.64332443
9Abnormality of the corticospinal tract (HP:0002492)3.54787188
10Abnormality of midbrain morphology (HP:0002418)3.43750955
11Molar tooth sign on MRI (HP:0002419)3.43750955
12Nephronophthisis (HP:0000090)3.34141702
13Increased IgE level (HP:0003212)3.26737392
14Absent rod-and cone-mediated responses on ERG (HP:0007688)3.21746588
15Renal Fanconi syndrome (HP:0001994)3.20172147
16Abnormal rod and cone electroretinograms (HP:0008323)3.19529536
17Peripheral hypomyelination (HP:0007182)3.09540620
18Pancreatic cysts (HP:0001737)3.03545107
19Abnormality of the renal medulla (HP:0100957)2.95204655
20Cerebral inclusion bodies (HP:0100314)2.93915685
21Pancreatic fibrosis (HP:0100732)2.93685243
22Chronic hepatic failure (HP:0100626)2.90158973
23Palmoplantar hyperkeratosis (HP:0000972)2.85402631
24Congenital ichthyosiform erythroderma (HP:0007431)2.82517823
25Cupped ear (HP:0000378)2.77181046
26Atonic seizures (HP:0010819)2.75626061
27Acute necrotizing encephalopathy (HP:0006965)2.74698055
28Patchy hypopigmentation of hair (HP:0011365)2.74152528
29White forelock (HP:0002211)2.72716069
30Palmar hyperkeratosis (HP:0010765)2.68226090
31True hermaphroditism (HP:0010459)2.67554698
32Adrenal hypoplasia (HP:0000835)2.66473087
33Increased hepatocellular lipid droplets (HP:0006565)2.65514865
34Absent/shortened dynein arms (HP:0200106)2.60670873
35Dynein arm defect of respiratory motile cilia (HP:0012255)2.60670873
36Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.58974218
37Oligodactyly (hands) (HP:0001180)2.58932543
38Alacrima (HP:0000522)2.53730377
39Stomatitis (HP:0010280)2.48697553
40Mitochondrial inheritance (HP:0001427)2.46679329
41Cerebral hypomyelination (HP:0006808)2.46428976
42Abnormal hair whorl (HP:0010721)2.46200683
43Leukodystrophy (HP:0002415)2.45825732
443-Methylglutaconic aciduria (HP:0003535)2.45137306
45Abnormal ciliary motility (HP:0012262)2.44145627
46Focal motor seizures (HP:0011153)2.44017444
47Oral leukoplakia (HP:0002745)2.43554293
48Split foot (HP:0001839)2.40606662
49Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.40596471
50Abnormal drinking behavior (HP:0030082)2.39183395
51Polydipsia (HP:0001959)2.39183395
52Type II lissencephaly (HP:0007260)2.38007410
53Abnormality of cells of the erythroid lineage (HP:0012130)2.37768248
54Akinesia (HP:0002304)2.37375214
55Furrowed tongue (HP:0000221)2.36130498
56Retinal dysplasia (HP:0007973)2.33184434
57Tubular atrophy (HP:0000092)2.31706600
58Abnormal number of erythroid precursors (HP:0012131)2.30159153
59Cystic liver disease (HP:0006706)2.28487884
60Anomalous pulmonary venous return (HP:0010772)2.28125970
61Absent septum pellucidum (HP:0001331)2.25935962
62Small epiphyses (HP:0010585)2.25715310
63Optic disc pallor (HP:0000543)2.25672517
64Thickened helices (HP:0000391)2.24351611
65Abnormality of incisor morphology (HP:0011063)2.23457037
66Progressive macrocephaly (HP:0004481)2.23128281
67Conical tooth (HP:0000698)2.22889268
68Dysmetria (HP:0001310)2.21291743
69Vaginal atresia (HP:0000148)2.19223777
70Scanning speech (HP:0002168)2.18534517
71Bile duct proliferation (HP:0001408)2.17792966
72Abnormal biliary tract physiology (HP:0012439)2.17792966
73Septo-optic dysplasia (HP:0100842)2.17431976
74Medial flaring of the eyebrow (HP:0010747)2.17123459
75Gangrene (HP:0100758)2.16122383
76Supranuclear gaze palsy (HP:0000605)2.15995825
77Abolished electroretinogram (ERG) (HP:0000550)2.15506053
78Aplasia/Hypoplasia of the spleen (HP:0010451)2.14935011
79Reticulocytopenia (HP:0001896)2.14334456
80Abnormality of renal resorption (HP:0011038)2.14116495
81Growth hormone deficiency (HP:0000824)2.13611609
82Nephrogenic diabetes insipidus (HP:0009806)2.13543890
83Genital tract atresia (HP:0001827)2.12585823
84Plantar hyperkeratosis (HP:0007556)2.12118243
85Increased serum pyruvate (HP:0003542)2.11798982
86Abnormality of glycolysis (HP:0004366)2.11798982
87Abnormal respiratory motile cilium morphology (HP:0005938)2.10833394
88Abnormal respiratory epithelium morphology (HP:0012253)2.10833394
89Synostosis involving the elbow (HP:0003938)2.10539654
90Humeroradial synostosis (HP:0003041)2.10539654
91Progressive cerebellar ataxia (HP:0002073)2.10165740
92Hypoplastic pelvis (HP:0008839)2.06794037
93Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.06777905
94Abnormal mitochondria in muscle tissue (HP:0008316)2.06487642
95Agitation (HP:0000713)2.06368876
96Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.06109807
97Abnormality of the renal cortex (HP:0011035)2.05976956
98Lipid accumulation in hepatocytes (HP:0006561)2.05276438
99Spastic gait (HP:0002064)2.04483658
100Hypomagnesemia (HP:0002917)2.04087706
101Abnormality of the septum pellucidum (HP:0007375)2.02974505
102Hyperventilation (HP:0002883)2.02934688
103Abnormal respiratory motile cilium physiology (HP:0012261)2.01376395
104Acute encephalopathy (HP:0006846)2.01215157
105Gait imbalance (HP:0002141)2.00334200
106Polyphagia (HP:0002591)2.00114457
107Asplenia (HP:0001746)2.00045809
108Abnormality of the renal collecting system (HP:0004742)1.99999541
109Abnormality of the pulmonary veins (HP:0011718)1.99941501
110Pendular nystagmus (HP:0012043)1.97946524
111Diminished movement (HP:0002374)1.96995654
112Hypothermia (HP:0002045)1.95589343
113Autoamputation (HP:0001218)1.94857009
114Corneal erosion (HP:0200020)1.90952363
115Decreased lacrimation (HP:0000633)1.90102863
116Poor coordination (HP:0002370)1.89573970
117Alopecia of scalp (HP:0002293)1.88929763
118Pustule (HP:0200039)1.88624965
119Febrile seizures (HP:0002373)1.88500185
120Broad-based gait (HP:0002136)1.87653255
121Partial agenesis of the corpus callosum (HP:0001338)1.87068551
122Epileptic encephalopathy (HP:0200134)1.86763341
123Elevated erythrocyte sedimentation rate (HP:0003565)1.86281610
124Onion bulb formation (HP:0003383)1.86090915
125Congenital primary aphakia (HP:0007707)1.85821126
126Optic nerve hypoplasia (HP:0000609)1.85361977
127Focal seizures (HP:0007359)1.85063025
128Anteriorly placed anus (HP:0001545)1.84419118
129Rib fusion (HP:0000902)1.84041774
130Bowel incontinence (HP:0002607)1.83917733
131Fetal akinesia sequence (HP:0001989)1.83436490
132Congenital sensorineural hearing impairment (HP:0008527)1.83042198
133Decreased central vision (HP:0007663)1.83038784
134Sclerocornea (HP:0000647)1.83007209
135Esotropia (HP:0000565)1.82336644
136Intention tremor (HP:0002080)1.82307218
137Slow saccadic eye movements (HP:0000514)1.80766423
138Myokymia (HP:0002411)1.80148414
139Abnormal pancreas size (HP:0012094)1.79373241
140Congenital hepatic fibrosis (HP:0002612)1.78447234
141Erythroderma (HP:0001019)1.78198114
142Genetic anticipation (HP:0003743)1.78146340
143Abnormal delayed hypersensitivity skin test (HP:0002963)1.78091921
144Abnormal large intestine physiology (HP:0012700)1.77907393
145Nasolacrimal duct obstruction (HP:0000579)1.77836666
146Limb dystonia (HP:0002451)1.77521380
147Esophageal atresia (HP:0002032)1.77299903
148Increased CSF lactate (HP:0002490)1.76961813
149Overfolded helix (HP:0000396)1.76765759
150Tachypnea (HP:0002789)1.76715269
151Abnormality of the phalanges of the 2nd finger (HP:0009541)1.76610197
152Abnormality of secondary sexual hair (HP:0009888)1.76369814
153Abnormality of the axillary hair (HP:0100134)1.76369814
154Morphological abnormality of the inner ear (HP:0011390)1.76312691
155Polyuria (HP:0000103)1.75287063
156Duplicated collecting system (HP:0000081)1.75041275
157Concave nail (HP:0001598)1.75004555
158Cerebellar dysplasia (HP:0007033)1.74683104
159Abnormal eating behavior (HP:0100738)1.74248001
160Inability to walk (HP:0002540)1.72578727
161Hypohidrosis (HP:0000966)1.71999871
162Keratoconjunctivitis (HP:0001096)1.70086209
163Erythema (HP:0010783)1.69740321
164Hyperglycinemia (HP:0002154)1.69492855
165Retrobulbar optic neuritis (HP:0100654)1.69030022
166Optic neuritis (HP:0100653)1.69030022
167Oligodactyly (HP:0012165)1.66952342
168Anencephaly (HP:0002323)1.66586119
169Neoplasm of the adrenal cortex (HP:0100641)1.63698845
170Abnormality of hair growth rate (HP:0011363)1.62959019
171Slow-growing hair (HP:0002217)1.62959019
172Abnormality of DNA repair (HP:0003254)1.60300570
173Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.59724077
174Tetany (HP:0001281)1.59441691
175Anophthalmia (HP:0000528)1.59314633
176Diastasis recti (HP:0001540)1.58771915

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK394.98712148
2TNIK4.40779010
3OXSR13.56824687
4CASK3.06376365
5PINK12.45974710
6CDK192.39360003
7BCR2.30477665
8PNCK2.29493919
9TNK22.28441909
10WNK42.19476330
11EPHA42.10118903
12MST42.05641537
13MAP3K112.03688823
14NEK62.01565543
15FRK1.99707327
16TXK1.99240588
17EPHB11.97850061
18PKN11.96050025
19SIK21.92284980
20PBK1.90173885
21MARK11.78732577
22CAMKK21.69471681
23MAP4K11.65384320
24PRPF4B1.62916797
25FGFR21.58052989
26IRAK21.56069530
27CAMKK11.53679753
28UHMK11.49990646
29CSNK1G31.45323584
30WNK11.44478066
31MAPKAPK51.41432980
32STK111.36404945
33FGR1.36094733
34CLK11.32408210
35CAMK2B1.29016134
36MAPK131.28065691
37GRK71.27138333
38MAP3K61.26505015
39MAP2K61.26215860
40MAP2K41.24825460
41CSNK1A1L1.23978305
42MET1.23009922
43TESK21.21027412
44ADRBK21.20947642
45BMPR1B1.17538591
46TAOK31.16915289
47BMPR21.16446545
48IKBKE1.15351271
49MAP2K71.15304463
50CAMK2D1.13640035
51GRK61.13280660
52NME11.12770261
53ROCK21.12715685
54IRAK41.11012890
55MUSK1.10687149
56MAP4K21.09685874
57FES1.09505693
58IRAK11.06997453
59CSNK1G11.06042012
60CSNK1G21.01221896
61LIMK10.99844219
62CAMK2A0.97277068
63DYRK20.95848595
64BTK0.93264631
65DAPK20.92862075
66CAMK10.92696798
67NLK0.91778250
68TAOK10.90537763
69STK160.89742250
70IKBKB0.89285189
71CSK0.87931941
72MAP3K70.87630684
73NTRK10.85800537
74MKNK10.84282973
75PRKCZ0.84125990
76PRKD30.83694089
77ITK0.83676296
78PRKD20.83552133
79SYK0.82494165
80BCKDK0.81052492
81GRK50.80977178
82CAMK1D0.80839459
83TGFBR10.80687220
84MAPK150.80168990
85PRKCQ0.80111811
86PRKCE0.79189569
87MKNK20.77426685
88ICK0.77308850
89PRKCH0.75585338
90MARK30.75426238
91CDK50.74999613
92PLK20.74586719
93SGK20.73242071
94MAPKAPK30.73139073
95RPS6KA60.73106700
96NTRK20.72977911
97DYRK1B0.72945609
98ACVR1B0.69996207
99TYRO30.69808115
100LCK0.66743285
101SGK4940.66299153
102SGK2230.66299153
103CDK30.65795170
104CAMK2G0.65733985
105YES10.64156580
106NTRK30.63351835
107CDK140.62121359
108MAPK120.58305622
109MAP2K20.56116871
110LYN0.55813758
111SGK10.54807295
112NUAK10.54531605
113WNK30.54224866
114PASK0.53751319
115MAP3K90.52192958
116MARK20.51732015
117HCK0.51614008
118CDK180.51298285
119CDK150.51172369
120DYRK1A0.50181814
121CDK11A0.50012144
122MAP3K120.49366561
123MAPK70.48893218
124CAMK40.47894358
125RPS6KC10.47796778
126RPS6KL10.47796778
127ZAK0.47788374
128PRKCI0.47258767
129ARAF0.46933965
130PRKG10.46460428
131CAMK1G0.45148530
132PRKACA0.44412599
133ADRBK10.44264856
134IRAK30.44094634
135MAP3K40.43971606
136RPS6KA50.43901106
137STK240.42691842
138TLK10.42677167
139FYN0.41974314
140TBK10.41750144
141PRKCG0.41717876
142PHKG10.39606142
143PHKG20.39606142
144PAK30.38960879
145GRK10.38769327
146CSNK1A10.38760515
147OBSCN0.38755034
148VRK10.36641005
149INSRR0.36599000
150RIPK40.35341083
151MINK10.33895973
152ERBB40.32695408
153ABL20.31352014
154AKT30.30998994
155TRPM70.30812998
156PTK2B0.30722833
157BLK0.30557967

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009004.67010468
2Oxidative phosphorylation_Homo sapiens_hsa001903.66542031
3Steroid biosynthesis_Homo sapiens_hsa001003.48415370
4Fatty acid elongation_Homo sapiens_hsa000623.07248963
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.86229169
6Parkinsons disease_Homo sapiens_hsa050122.54922705
7Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.51842307
8* Ether lipid metabolism_Homo sapiens_hsa005652.41032970
9Alzheimers disease_Homo sapiens_hsa050102.32399284
10Nicotine addiction_Homo sapiens_hsa050332.28085094
11Protein export_Homo sapiens_hsa030602.24382578
12Collecting duct acid secretion_Homo sapiens_hsa049662.03541201
13Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.03461619
14* Serotonergic synapse_Homo sapiens_hsa047261.92306261
15Axon guidance_Homo sapiens_hsa043601.86789287
16Sphingolipid metabolism_Homo sapiens_hsa006001.83619242
17Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.81458098
18Huntingtons disease_Homo sapiens_hsa050161.77521260
19Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.71242118
20* Glutamatergic synapse_Homo sapiens_hsa047241.69883313
21GABAergic synapse_Homo sapiens_hsa047271.62554227
22Taste transduction_Homo sapiens_hsa047421.58787687
23Morphine addiction_Homo sapiens_hsa050321.56043897
24Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.53514999
25Primary immunodeficiency_Homo sapiens_hsa053401.52260413
26Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.50581606
27Vibrio cholerae infection_Homo sapiens_hsa051101.46998824
28* Glycerophospholipid metabolism_Homo sapiens_hsa005641.41439762
29Rheumatoid arthritis_Homo sapiens_hsa053231.38402352
30Phototransduction_Homo sapiens_hsa047441.32914832
31Cardiac muscle contraction_Homo sapiens_hsa042601.28651145
32Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.26733069
33Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.21338495
34RNA polymerase_Homo sapiens_hsa030201.20067872
35Sulfur metabolism_Homo sapiens_hsa009201.19447269
36ABC transporters_Homo sapiens_hsa020101.18860724
37Glycerolipid metabolism_Homo sapiens_hsa005611.16653820
38NOD-like receptor signaling pathway_Homo sapiens_hsa046211.15118609
39SNARE interactions in vesicular transport_Homo sapiens_hsa041301.10004212
40Synaptic vesicle cycle_Homo sapiens_hsa047211.08915942
41Fat digestion and absorption_Homo sapiens_hsa049751.06696563
42* Long-term depression_Homo sapiens_hsa047301.06452390
43Circadian entrainment_Homo sapiens_hsa047131.05573375
44Proteasome_Homo sapiens_hsa030501.04858314
45Notch signaling pathway_Homo sapiens_hsa043301.04850924
46Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.02615742
47Autoimmune thyroid disease_Homo sapiens_hsa053201.00376081
48Maturity onset diabetes of the young_Homo sapiens_hsa049500.99276381
49Nitrogen metabolism_Homo sapiens_hsa009100.98318132
50Caffeine metabolism_Homo sapiens_hsa002320.97785114
51Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.97144910
52RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.96879607
53Dopaminergic synapse_Homo sapiens_hsa047280.92067024
54Intestinal immune network for IgA production_Homo sapiens_hsa046720.88944484
55* Arachidonic acid metabolism_Homo sapiens_hsa005900.86386927
56Salivary secretion_Homo sapiens_hsa049700.85828810
57* Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.85341572
58Carbohydrate digestion and absorption_Homo sapiens_hsa049730.85205596
59Cholinergic synapse_Homo sapiens_hsa047250.84346932
60Histidine metabolism_Homo sapiens_hsa003400.81761460
61T cell receptor signaling pathway_Homo sapiens_hsa046600.81215445
62* Linoleic acid metabolism_Homo sapiens_hsa005910.80944779
63Amphetamine addiction_Homo sapiens_hsa050310.79262849
64Cocaine addiction_Homo sapiens_hsa050300.78722600
65Aldosterone synthesis and secretion_Homo sapiens_hsa049250.78324579
66Phagosome_Homo sapiens_hsa041450.76755956
67Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.74154257
68* GnRH signaling pathway_Homo sapiens_hsa049120.73136092
69Primary bile acid biosynthesis_Homo sapiens_hsa001200.72260536
70Glycosaminoglycan degradation_Homo sapiens_hsa005310.70332146
71Vitamin B6 metabolism_Homo sapiens_hsa007500.69977694
72Renin secretion_Homo sapiens_hsa049240.69380953
73Calcium signaling pathway_Homo sapiens_hsa040200.68830185
74Hedgehog signaling pathway_Homo sapiens_hsa043400.66671970
75Chemical carcinogenesis_Homo sapiens_hsa052040.65027199
76Tryptophan metabolism_Homo sapiens_hsa003800.62829125
77Butanoate metabolism_Homo sapiens_hsa006500.62723720
78Chemokine signaling pathway_Homo sapiens_hsa040620.62216973
79Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.61510937
80Type I diabetes mellitus_Homo sapiens_hsa049400.61071676
81Arginine and proline metabolism_Homo sapiens_hsa003300.60607216
82* Ras signaling pathway_Homo sapiens_hsa040140.58907745
83Sphingolipid signaling pathway_Homo sapiens_hsa040710.58347992
84Olfactory transduction_Homo sapiens_hsa047400.57939470
85Peroxisome_Homo sapiens_hsa041460.57874223
86* Vascular smooth muscle contraction_Homo sapiens_hsa042700.57680087
87Basal transcription factors_Homo sapiens_hsa030220.57529889
88Long-term potentiation_Homo sapiens_hsa047200.54696809
89Graft-versus-host disease_Homo sapiens_hsa053320.54081857
90* alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.53655817
91Vitamin digestion and absorption_Homo sapiens_hsa049770.52851592
92Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.51339036
93Ribosome_Homo sapiens_hsa030100.51236360
94* VEGF signaling pathway_Homo sapiens_hsa043700.51072238
95African trypanosomiasis_Homo sapiens_hsa051430.51016372
96Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.49640533
97Staphylococcus aureus infection_Homo sapiens_hsa051500.49285991
98Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.48835039
99Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.48513475
100Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.47890837
101Basal cell carcinoma_Homo sapiens_hsa052170.47598326
102* Metabolic pathways_Homo sapiens_hsa011000.46893033
103Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.45837958
104Fanconi anemia pathway_Homo sapiens_hsa034600.45384821
105* Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.45182322
106Renal cell carcinoma_Homo sapiens_hsa052110.44846233
107Gastric acid secretion_Homo sapiens_hsa049710.44678042
108Asthma_Homo sapiens_hsa053100.44506981
109Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.44473085
110Steroid hormone biosynthesis_Homo sapiens_hsa001400.43469275
111Osteoclast differentiation_Homo sapiens_hsa043800.43381951
112Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.42519112
113Malaria_Homo sapiens_hsa051440.42443588
114Allograft rejection_Homo sapiens_hsa053300.42206683
115* Ovarian steroidogenesis_Homo sapiens_hsa049130.41478383
116Glutathione metabolism_Homo sapiens_hsa004800.40858511
117* Oxytocin signaling pathway_Homo sapiens_hsa049210.40171225
118Pancreatic secretion_Homo sapiens_hsa049720.39683226
119Gap junction_Homo sapiens_hsa045400.39555940
120Melanogenesis_Homo sapiens_hsa049160.38907863
121Tyrosine metabolism_Homo sapiens_hsa003500.38419648
122Wnt signaling pathway_Homo sapiens_hsa043100.36278659
123cAMP signaling pathway_Homo sapiens_hsa040240.33784200
124Regulation of autophagy_Homo sapiens_hsa041400.33745743
125Tight junction_Homo sapiens_hsa045300.32273006
126ErbB signaling pathway_Homo sapiens_hsa040120.31991678
127ECM-receptor interaction_Homo sapiens_hsa045120.31113759
128Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.31022570
129Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.30989740
130Mineral absorption_Homo sapiens_hsa049780.30898951
131Alcoholism_Homo sapiens_hsa050340.30888177
132* Phospholipase D signaling pathway_Homo sapiens_hsa040720.29699699
133Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.29436743
134Non-homologous end-joining_Homo sapiens_hsa034500.27204322
135Dorso-ventral axis formation_Homo sapiens_hsa043200.26727577
136Insulin secretion_Homo sapiens_hsa049110.26634294
137* MAPK signaling pathway_Homo sapiens_hsa040100.25739357

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