PLA2G4C

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein which is a member of the phospholipase A2 enzyme family which hydrolyzes glycerophospholipids to produce free fatty acids and lysophospholipids, both of which serve as precursors in the production of signaling molecules. The encoded protein has been shown to be a calcium-independent and membrane bound enzyme. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of female gonad development (GO:2000194)6.26088343
2intestinal absorption (GO:0050892)6.24172479
3piRNA metabolic process (GO:0034587)6.16169552
4female gamete generation (GO:0007292)5.81024611
5negative regulation of hormone biosynthetic process (GO:0032353)5.63618990
6negative regulation of hormone metabolic process (GO:0032351)5.63618990
7regulation of meiosis (GO:0040020)5.63368731
8mitotic metaphase plate congression (GO:0007080)5.54471657
9regulation of meiosis I (GO:0060631)5.19526335
10mitotic chromosome condensation (GO:0007076)5.19262420
11regulation of sister chromatid cohesion (GO:0007063)5.04694074
12meiotic cell cycle (GO:0051321)5.04625097
13regulation of RIG-I signaling pathway (GO:0039535)4.91735759
14regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.84764741
15intestinal cholesterol absorption (GO:0030299)4.83431273
16meiotic chromosome segregation (GO:0045132)4.83281625
17attachment of spindle microtubules to kinetochore (GO:0008608)4.78216743
18mitotic sister chromatid segregation (GO:0000070)4.76804950
19maturation of 5.8S rRNA (GO:0000460)4.76121154
20DNA damage induced protein phosphorylation (GO:0006975)4.73536200
21negative regulation of retinoic acid receptor signaling pathway (GO:0048387)4.71792456
22behavioral response to nicotine (GO:0035095)4.62324011
23negative regulation of meiosis (GO:0045835)4.60517351
24metaphase plate congression (GO:0051310)4.60206681
25oocyte maturation (GO:0001556)4.52985205
26regulation of glucocorticoid metabolic process (GO:0031943)4.50623383
27regulation of meiotic cell cycle (GO:0051445)4.45549104
28histone H2A monoubiquitination (GO:0035518)4.42701851
29DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla4.37569085
30regulation of exit from mitosis (GO:0007096)4.37029556
31establishment of chromosome localization (GO:0051303)4.31216597
32positive regulation of megakaryocyte differentiation (GO:0045654)4.25821516
33DNA damage response, signal transduction resulting in transcription (GO:0042772)4.24395188
34male meiosis (GO:0007140)4.17026030
35indole-containing compound catabolic process (GO:0042436)4.14551308
36indolalkylamine catabolic process (GO:0046218)4.14551308
37tryptophan catabolic process (GO:0006569)4.14551308
38regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)4.11095071
39regulation of histone H3-K27 methylation (GO:0061085)4.07935682
40kynurenine metabolic process (GO:0070189)4.03372272
41angiotensin maturation (GO:0002003)4.02808887
42membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.90351001
43DNA methylation involved in gamete generation (GO:0043046)3.88912667
44sister chromatid segregation (GO:0000819)3.84160619
45drug catabolic process (GO:0042737)3.77296362
46regulation of transforming growth factor beta2 production (GO:0032909)3.73741682
47positive regulation of chromosome segregation (GO:0051984)3.71896756
48negative regulation of reproductive process (GO:2000242)3.68522788
49regulation of retinoic acid receptor signaling pathway (GO:0048385)3.66631813
50histone H2A ubiquitination (GO:0033522)3.66276711
51chromosome segregation (GO:0007059)3.62892276
52positive regulation of mitotic sister chromatid separation (GO:1901970)3.62015369
53positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.62015369
54positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.62015369
55indolalkylamine metabolic process (GO:0006586)3.61066275
56negative regulation of meiotic cell cycle (GO:0051447)3.59013613
57protein K6-linked ubiquitination (GO:0085020)3.55139131
58intestinal epithelial cell development (GO:0060576)3.54272965
59female gonad development (GO:0008585)3.53671290
60neuronal action potential propagation (GO:0019227)3.53323391
61vitamin A metabolic process (GO:0006776)3.49624227
62regulation of skeletal muscle contraction (GO:0014819)3.48179441
63negative regulation of smooth muscle cell differentiation (GO:0051151)3.46943750
64positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)3.44330618
65protein localization to kinetochore (GO:0034501)3.44290314
66myoblast migration (GO:0051451)3.43742197
67negative regulation of circadian rhythm (GO:0042754)3.43554777
68tryptophan metabolic process (GO:0006568)3.43409315
69protein localization to chromosome, centromeric region (GO:0071459)3.41280792
70regulation of DNA methylation (GO:0044030)3.39819473
71sulfate transmembrane transport (GO:1902358)3.39186887
72regulation of spindle organization (GO:0090224)3.37305032
73type B pancreatic cell development (GO:0003323)3.36365842
74protein localization to chromosome (GO:0034502)3.35845695
75replication fork processing (GO:0031297)3.34293273
76kinetochore assembly (GO:0051382)3.31596432
77detection of light stimulus involved in sensory perception (GO:0050962)3.30184073
78detection of light stimulus involved in visual perception (GO:0050908)3.30184073
79exogenous drug catabolic process (GO:0042738)3.29000915
80cellular ketone body metabolic process (GO:0046950)3.27241886
81DNA deamination (GO:0045006)3.27238462
82L-fucose catabolic process (GO:0042355)3.24735725
83fucose catabolic process (GO:0019317)3.24735725
84L-fucose metabolic process (GO:0042354)3.24735725
85regulation of steroid hormone biosynthetic process (GO:0090030)3.24605949
86maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.24253248
87notochord development (GO:0030903)3.21475729
88regulation of double-strand break repair via homologous recombination (GO:0010569)3.20239377
89regulation of chromosome segregation (GO:0051983)3.19754761
90regulation of mononuclear cell migration (GO:0071675)3.19311234
91CENP-A containing nucleosome assembly (GO:0034080)3.19304444
92positive regulation of DNA-dependent DNA replication (GO:2000105)3.18675602
93monoubiquitinated protein deubiquitination (GO:0035520)3.17491904
94detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.17055000
95negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.15364128
96negative regulation of DNA-templated transcription, elongation (GO:0032785)3.15364128
97chromatin remodeling at centromere (GO:0031055)3.15124373
98kinetochore organization (GO:0051383)3.15044962
99cellular biogenic amine catabolic process (GO:0042402)3.14935091
100amine catabolic process (GO:0009310)3.14935091
101cytoplasmic mRNA processing body assembly (GO:0033962)3.14084420
102aromatic amino acid family catabolic process (GO:0009074)3.14000691
103regulation of mitotic spindle organization (GO:0060236)3.13194752
104oogenesis (GO:0048477)3.13133593
105gene silencing by RNA (GO:0031047)3.12293865
106mitotic nuclear envelope disassembly (GO:0007077)3.10486263
107gamma-aminobutyric acid transport (GO:0015812)3.09629983
108indole-containing compound metabolic process (GO:0042430)3.06257976
109spindle checkpoint (GO:0031577)3.05254253
110columnar/cuboidal epithelial cell development (GO:0002066)3.05063377
111sarcoplasmic reticulum calcium ion transport (GO:0070296)3.03718401
112positive regulation of sodium ion transmembrane transporter activity (GO:2000651)3.01817112
113platelet dense granule organization (GO:0060155)3.00360802
114positive regulation of Cdc42 GTPase activity (GO:0043089)3.00018786
115sulfate transport (GO:0008272)2.99525835
116DNA replication-independent nucleosome assembly (GO:0006336)2.97330344
117DNA replication-independent nucleosome organization (GO:0034724)2.97330344
118regulation of acrosome reaction (GO:0060046)2.96652215
119regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.93976353
120negative regulation of cell division (GO:0051782)2.92625949
121membrane depolarization during action potential (GO:0086010)2.92280088
122membrane disassembly (GO:0030397)2.91336148
123nuclear envelope disassembly (GO:0051081)2.91336148
124negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.90816302
125negative regulation of cytosolic calcium ion concentration (GO:0051481)2.90391789
126regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.90364995
127negative regulation of steroid biosynthetic process (GO:0010894)2.89389575
128ketone body metabolic process (GO:1902224)2.88728281
129microtubule nucleation (GO:0007020)2.88624932
130neuronal action potential (GO:0019228)2.86774544
131negative regulation of telomere maintenance (GO:0032205)2.83904344
132L-methionine salvage (GO:0071267)2.80311037
133L-methionine biosynthetic process (GO:0071265)2.80311037
134amino acid salvage (GO:0043102)2.80311037
135negative regulation of synaptic transmission, GABAergic (GO:0032229)2.77794948
136synaptic transmission, cholinergic (GO:0007271)2.77681859
137response to pheromone (GO:0019236)2.77125481
138auditory receptor cell stereocilium organization (GO:0060088)2.76999247
139regulation of action potential (GO:0098900)2.75193492
140protein complex biogenesis (GO:0070271)2.68145645
141regulation of hexokinase activity (GO:1903299)2.64936272
142regulation of glucokinase activity (GO:0033131)2.64936272
143retinal cone cell development (GO:0046549)2.64544347
144water-soluble vitamin biosynthetic process (GO:0042364)2.62224081
145dopamine transport (GO:0015872)2.62157058
146G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.61940228
147primary amino compound metabolic process (GO:1901160)2.61256550
148regulation of relaxation of muscle (GO:1901077)2.58678181
149muscle filament sliding (GO:0030049)2.58048259
150actin-myosin filament sliding (GO:0033275)2.58048259
151L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.56689500
152regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.56622779
153cellular response to ATP (GO:0071318)2.52987588
154serotonin metabolic process (GO:0042428)2.51895078
155positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.51859526
156benzene-containing compound metabolic process (GO:0042537)2.51654729
157protein polyglutamylation (GO:0018095)2.51568105
158cAMP catabolic process (GO:0006198)2.51413469
159positive regulation of sodium ion transmembrane transport (GO:1902307)2.50866193
160neuromuscular synaptic transmission (GO:0007274)2.50688399
161mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.50570839
162mitochondrial respiratory chain complex I assembly (GO:0032981)2.50570839
163NADH dehydrogenase complex assembly (GO:0010257)2.50570839
164NAD biosynthetic process (GO:0009435)2.49679735
165cytidine deamination (GO:0009972)2.47034770
166cytidine metabolic process (GO:0046087)2.47034770
167cytidine catabolic process (GO:0006216)2.47034770
168positive regulation of fatty acid transport (GO:2000193)2.45472028
169transmission of nerve impulse (GO:0019226)2.45411004
170mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.44361584
171oxidative demethylation (GO:0070989)2.44081990
172regulation of cell communication by electrical coupling (GO:0010649)2.43866640
173respiratory chain complex IV assembly (GO:0008535)2.43645174
174cyclic nucleotide catabolic process (GO:0009214)2.41818533
175axoneme assembly (GO:0035082)2.41746154
176negative regulation of mast cell activation (GO:0033004)2.39753187
177glyoxylate metabolic process (GO:0046487)2.39418385
178regulation of neurotransmitter uptake (GO:0051580)2.39175431
179reflex (GO:0060004)2.38151732
180action potential (GO:0001508)2.37047774
181neurotransmitter metabolic process (GO:0042133)2.36079141
182proline transport (GO:0015824)2.35664601
183S-adenosylmethionine metabolic process (GO:0046500)2.34855002
184positive regulation of meiosis (GO:0045836)2.34226607
185regulation of rhodopsin mediated signaling pathway (GO:0022400)2.32752232
186multicellular organism reproduction (GO:0032504)2.32553819
187negative regulation of reactive oxygen species metabolic process (GO:2000378)2.32245200
188ubiquinone biosynthetic process (GO:0006744)2.31386196
189alanine transport (GO:0032328)2.31246964
190positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.30414180
191mitochondrial respiratory chain complex assembly (GO:0033108)2.30143286
192aromatic amino acid family metabolic process (GO:0009072)2.30124167
193sulfation (GO:0051923)2.29327226
194epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.26130529
195cytochrome complex assembly (GO:0017004)2.26032051
196inner ear receptor stereocilium organization (GO:0060122)2.25768121
197positive regulation of cAMP-mediated signaling (GO:0043950)2.25690470
198postsynaptic membrane organization (GO:0001941)2.25671538

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human5.74480625
2EZH2_22144423_ChIP-Seq_EOC_Human4.26696998
3FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human4.04306838
4E2F7_22180533_ChIP-Seq_HELA_Human3.84472951
5* KAP1_22055183_ChIP-Seq_ESCs_Mouse3.80397315
6AR_21909140_ChIP-Seq_LNCAP_Human3.61336775
7SALL1_21062744_ChIP-ChIP_HESCs_Human3.60237113
8NANOG_18700969_ChIP-ChIP_MESCs_Mouse3.58430016
9SMAD_19615063_ChIP-ChIP_OVARY_Human3.40397072
10RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.18854608
11GBX2_23144817_ChIP-Seq_PC3_Human3.08150650
12ZNF274_21170338_ChIP-Seq_K562_Hela2.87074662
13GATA1_26923725_Chip-Seq_HPCs_Mouse2.87020049
14MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.84161235
15GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.64516047
16ZFP57_27257070_Chip-Seq_ESCs_Mouse2.35847668
17STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.02460144
18TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.98393197
19SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.96155473
20CTBP2_25329375_ChIP-Seq_LNCAP_Human1.95482715
21GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.90789410
22E2F4_17652178_ChIP-ChIP_JURKAT_Human1.83956456
23SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.80543825
24CTBP1_25329375_ChIP-Seq_LNCAP_Human1.78846951
25P300_19829295_ChIP-Seq_ESCs_Human1.76679969
26TAF15_26573619_Chip-Seq_HEK293_Human1.73912989
27ESR1_20079471_ChIP-ChIP_T-47D_Human1.71522281
28NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.69319000
29TCF3_18692474_ChIP-Seq_MESCs_Mouse1.67855723
30ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.66335178
31REST_21632747_ChIP-Seq_MESCs_Mouse1.66321402
32ER_23166858_ChIP-Seq_MCF-7_Human1.66229915
33TP63_17297297_ChIP-ChIP_HaCaT_Human1.59890374
34RUNX1_26923725_Chip-Seq_HPCs_Mouse1.59378161
35BCAT_22108803_ChIP-Seq_LS180_Human1.56763148
36MYC_18940864_ChIP-ChIP_HL60_Human1.55779179
37SMAD4_21799915_ChIP-Seq_A2780_Human1.54695846
38HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.53427467
39UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.52558874
40CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.51834951
41EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.51310117
42CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.50903618
43NANOG_18555785_ChIP-Seq_MESCs_Mouse1.50716115
44PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.46288189
45STAT1_17558387_ChIP-Seq_HELA_Human1.45872224
46AR_25329375_ChIP-Seq_VCAP_Human1.45751883
47IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.44213542
48CBP_20019798_ChIP-Seq_JUKART_Human1.44213542
49SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.43655036
50E2F1_21310950_ChIP-Seq_MCF-7_Human1.42529491
51TCF4_23295773_ChIP-Seq_U87_Human1.41896141
52FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.41376674
53PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.41182364
54MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.41086864
55PIAS1_25552417_ChIP-Seq_VCAP_Human1.39896582
56SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.37616657
57FOXM1_26456572_ChIP-Seq_MCF-7_Human1.36310609
58NR3C1_21868756_ChIP-Seq_MCF10A_Human1.36219235
59NANOG_21062744_ChIP-ChIP_HESCs_Human1.35545757
60NANOG_19829295_ChIP-Seq_ESCs_Human1.35188208
61SOX2_19829295_ChIP-Seq_ESCs_Human1.35188208
62EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.35091050
63TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.35020705
64KAP1_27257070_Chip-Seq_ESCs_Mouse1.33229993
65SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.32616455
66EWS_26573619_Chip-Seq_HEK293_Human1.31803461
67DROSHA_22980978_ChIP-Seq_HELA_Human1.31348261
68SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.30169995
69EZH2_27294783_Chip-Seq_NPCs_Mouse1.28684778
70TP53_22573176_ChIP-Seq_HFKS_Human1.27627091
71* CDX2_22108803_ChIP-Seq_LS180_Human1.25304733
72TP63_19390658_ChIP-ChIP_HaCaT_Human1.25215959
73LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.24700125
74PCGF2_27294783_Chip-Seq_NPCs_Mouse1.23175198
75SMAD3_21741376_ChIP-Seq_EPCs_Human1.23057540
76SMAD4_21741376_ChIP-Seq_EPCs_Human1.22094342
77RNF2_27304074_Chip-Seq_NSC_Mouse1.20567067
78GATA6_25053715_ChIP-Seq_YYC3_Human1.20558408
79MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.20056581
80SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.19716589
81LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.19603980
82FLI1_21867929_ChIP-Seq_TH2_Mouse1.18882584
83REST_18959480_ChIP-ChIP_MESCs_Mouse1.18609560
84TOP2B_26459242_ChIP-Seq_MCF-7_Human1.18064432
85KLF5_20875108_ChIP-Seq_MESCs_Mouse1.18047528
86AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.18037311
87CRX_20693478_ChIP-Seq_RETINA_Mouse1.16687457
88FLI1_27457419_Chip-Seq_LIVER_Mouse1.16520276
89KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.16408283
90TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16090879
91POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.16090879
92FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.15850891
93TCF4_22108803_ChIP-Seq_LS180_Human1.15606127
94BMI1_23680149_ChIP-Seq_NPCS_Mouse1.15395300
95ELK4_26923725_Chip-Seq_MESODERM_Mouse1.15111645
96CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.14894741
97FOXA1_27270436_Chip-Seq_PROSTATE_Human1.14397085
98FOXA1_25329375_ChIP-Seq_VCAP_Human1.14397085
99EZH2_27294783_Chip-Seq_ESCs_Mouse1.14288468
100GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.14265404
101SALL4_18804426_ChIP-ChIP_XEN_Mouse1.14060304
102PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.13403157
103PPAR_26484153_Chip-Seq_NCI-H1993_Human1.12993310
104* PRDM14_20953172_ChIP-Seq_ESCs_Human1.12884344
105CBX2_27304074_Chip-Seq_ESCs_Mouse1.12275307
106RUNX2_22187159_ChIP-Seq_PCA_Human1.11390351
107GATA3_21878914_ChIP-Seq_MCF-7_Human1.11367112
108EGR1_23403033_ChIP-Seq_LIVER_Mouse1.10894360
109VDR_22108803_ChIP-Seq_LS180_Human1.10651238
110IRF8_22096565_ChIP-ChIP_GC-B_Human1.10208254
111NANOG_18692474_ChIP-Seq_MESCs_Mouse1.10118531
112* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.10022391
113OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.10019815
114SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.09883331
115CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.09275973
116IRF1_19129219_ChIP-ChIP_H3396_Human1.09138119
117MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.08260851
118NFYA_21822215_ChIP-Seq_K562_Human1.08047529
119TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.07532741
120FOXA1_21572438_ChIP-Seq_LNCaP_Human1.07306746
121PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.07090470
122KLF4_18555785_ChIP-Seq_MESCs_Mouse1.07037632
123FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.07019254
124P53_22387025_ChIP-Seq_ESCs_Mouse1.05717092
125CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.05550291
126ETV2_25802403_ChIP-Seq_MESCs_Mouse1.05526452
127NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.05524458
128TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.05487635
129* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.04768572
130EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.04125304
131TCF3_18692474_ChIP-Seq_MEFs_Mouse1.04087598
132HTT_18923047_ChIP-ChIP_STHdh_Human1.03856905
133NCOR_22424771_ChIP-Seq_293T_Human1.03446614
134* SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.03077059
135HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.02802425
136FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.01956253
137ATF3_27146783_Chip-Seq_COLON_Human1.01786177
138SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.01609877
139GATA4_25053715_ChIP-Seq_YYC3_Human1.01316634
140JARID2_20064375_ChIP-Seq_MESCs_Mouse1.01153749
141PCGF2_27294783_Chip-Seq_ESCs_Mouse1.00925070
142SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.00918781
143GATA3_21867929_ChIP-Seq_TH1_Mouse1.00321284
144PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.00281468
145SOX2_21211035_ChIP-Seq_LN229_Gbm0.99567538
146STAT3_18555785_Chip-Seq_ESCs_Mouse0.98689702
147OCT4_21477851_ChIP-Seq_ESCs_Mouse0.98633423
148TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.98494130
149STAT3_23295773_ChIP-Seq_U87_Human0.97517642
150SPI1_26923725_Chip-Seq_HPCs_Mouse0.96733136
151ERG_20517297_ChIP-Seq_VCAP_Human0.96286630
152FUS_26573619_Chip-Seq_HEK293_Human0.95508756
153TBL1_22424771_ChIP-Seq_293T_Human0.95181250
154IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.93264809
155IGF1R_20145208_ChIP-Seq_DFB_Human0.92764885
156SUZ12_27294783_Chip-Seq_NPCs_Mouse0.91664022
157NANOG_20526341_ChIP-Seq_ESCs_Human0.91335083
158AUTS2_25519132_ChIP-Seq_293T-REX_Human0.90645563
159SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.89772454
160DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.86622730
161NANOG_18555785_Chip-Seq_ESCs_Mouse0.85462980
162HNFA_21074721_ChIP-Seq_CACO-2_Human0.84774042
163FOXO3_23340844_ChIP-Seq_DLD1_Human0.84723415
164POU5F1_16518401_ChIP-PET_MESCs_Mouse0.84142523
165POU3F2_20337985_ChIP-ChIP_501MEL_Human0.83996064
166* RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.83915224
167KDM2B_26808549_Chip-Seq_REH_Human0.83569174
168TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.83376563
169KLF4_18555785_Chip-Seq_ESCs_Mouse0.83094696
170STAT6_21828071_ChIP-Seq_BEAS2B_Human0.83041835
171TP63_23658742_ChIP-Seq_EP156T_Human0.82500787
172ESET_19884257_ChIP-Seq_ESCs_Mouse0.82268018
173GF1B_26923725_Chip-Seq_HPCs_Mouse0.80735550
174NFE2_27457419_Chip-Seq_LIVER_Mouse0.80280041
175NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.79893053
176CJUN_26792858_Chip-Seq_BT549_Human0.79815255
177ESRRB_18555785_Chip-Seq_ESCs_Mouse0.79390022
178STAT3_18555785_ChIP-Seq_MESCs_Mouse0.79235940
179ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.79094259
180POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.78879204

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003718_maternal_effect6.01678111
2MP0005360_urolithiasis5.65128990
3MP0005451_abnormal_body_composition5.23036140
4MP0002102_abnormal_ear_morphology4.06840793
5MP0003646_muscle_fatigue3.77306771
6MP0003693_abnormal_embryo_hatching3.62919890
7MP0004145_abnormal_muscle_electrophysio3.39043608
8MP0002837_dystrophic_cardiac_calcinosis3.27862702
9MP0002653_abnormal_ependyma_morphology3.13828790
10MP0003195_calcinosis3.07507495
11MP0004264_abnormal_extraembryonic_tissu2.96843228
12MP0000462_abnormal_digestive_system2.95111153
13MP0008877_abnormal_DNA_methylation2.94722219
14MP0010094_abnormal_chromosome_stability2.73261158
15MP0005395_other_phenotype2.58101662
16MP0010234_abnormal_vibrissa_follicle2.47090288
17MP0003111_abnormal_nucleus_morphology2.33696483
18MP0003699_abnormal_female_reproductive2.33120040
19MP0001119_abnormal_female_reproductive2.30261922
20MP0004957_abnormal_blastocyst_morpholog2.27449981
21MP0003077_abnormal_cell_cycle2.24945335
22MP0005551_abnormal_eye_electrophysiolog2.23585346
23MP0002249_abnormal_larynx_morphology2.22685564
24MP0001666_abnormal_nutrient_absorption2.20456853
25MP0009745_abnormal_behavioral_response2.16668502
26MP0009046_muscle_twitch2.13951592
27MP0002272_abnormal_nervous_system2.09422948
28MP0005167_abnormal_blood-brain_barrier2.09088428
29MP0001501_abnormal_sleep_pattern2.08443900
30MP0001968_abnormal_touch/_nociception2.04604646
31MP0000579_abnormal_nail_morphology2.03533389
32MP0009840_abnormal_foam_cell2.00007977
33MP0005408_hypopigmentation1.91005792
34MP0002064_seizures1.85387647
35MP0009697_abnormal_copulation1.83765605
36MP0004215_abnormal_myocardial_fiber1.82288396
37MP0004142_abnormal_muscle_tone1.78783014
38MP0000653_abnormal_sex_gland1.77356606
39MP0006276_abnormal_autonomic_nervous1.77125541
40MP0003880_abnormal_central_pattern1.76631890
41MP0002138_abnormal_hepatobiliary_system1.76112901
42MP0005645_abnormal_hypothalamus_physiol1.74396665
43MP0001929_abnormal_gametogenesis1.74333998
44MP0003011_delayed_dark_adaptation1.69176648
45MP0001486_abnormal_startle_reflex1.67869808
46MP0002332_abnormal_exercise_endurance1.59230534
47MP0000490_abnormal_crypts_of1.56831092
48MP0008872_abnormal_physiological_respon1.56458761
49MP0004043_abnormal_pH_regulation1.55131386
50MP0008057_abnormal_DNA_replication1.53809568
51MP0002735_abnormal_chemical_nociception1.53466020
52MP0002210_abnormal_sex_determination1.53204756
53MP0003787_abnormal_imprinting1.51934076
54MP0002139_abnormal_hepatobiliary_system1.51494792
55MP0003123_paternal_imprinting1.50961450
56MP0000749_muscle_degeneration1.49333780
57MP0002736_abnormal_nociception_after1.48846263
58MP0001986_abnormal_taste_sensitivity1.47710397
59MP0003635_abnormal_synaptic_transmissio1.47093393
60MP0002638_abnormal_pupillary_reflex1.42523977
61MP0002572_abnormal_emotion/affect_behav1.41777794
62MP0003937_abnormal_limbs/digits/tail_de1.40252122
63MP0003879_abnormal_hair_cell1.39607772
64MP0004130_abnormal_muscle_cell1.39194461
65MP0001970_abnormal_pain_threshold1.38877568
66MP0002733_abnormal_thermal_nociception1.38692809
67MP0003252_abnormal_bile_duct1.35877748
68MP0008932_abnormal_embryonic_tissue1.34930950
69MP0005253_abnormal_eye_physiology1.34689391
70MP0004036_abnormal_muscle_relaxation1.34686095
71MP0002063_abnormal_learning/memory/cond1.31077735
72MP0001984_abnormal_olfaction1.29525170
73MP0002734_abnormal_mechanical_nocicepti1.28246258
74MP0001485_abnormal_pinna_reflex1.27147566
75MP0005620_abnormal_muscle_contractility1.26093913
76MP0003121_genomic_imprinting1.24981465
77MP0002085_abnormal_embryonic_tissue1.23498463
78MP0003137_abnormal_impulse_conducting1.23425501
79MP0005386_behavior/neurological_phenoty1.22330602
80MP0004924_abnormal_behavior1.22330602
81MP0002067_abnormal_sensory_capabilities1.21502654
82MP0003315_abnormal_perineum_morphology1.20554468
83MP0003453_abnormal_keratinocyte_physiol1.20059329
84MP0004885_abnormal_endolymph1.19987134
85MP0005310_abnormal_salivary_gland1.19960803
86MP0000538_abnormal_urinary_bladder1.19636666
87MP0002161_abnormal_fertility/fecundity1.18118578
88MP0001730_embryonic_growth_arrest1.17503219
89MP0008775_abnormal_heart_ventricle1.16925859
90MP0001145_abnormal_male_reproductive1.16505939
91MP0005365_abnormal_bile_salt1.15893283
92MP0001697_abnormal_embryo_size1.15058056
93MP0000230_abnormal_systemic_arterial1.13661812
94MP0005423_abnormal_somatic_nervous1.13600382
95MP0001502_abnormal_circadian_rhythm1.12813146
96MP0006036_abnormal_mitochondrial_physio1.11958901
97MP0003183_abnormal_peptide_metabolism1.11662789
98MP0003656_abnormal_erythrocyte_physiolo1.11150239
99MP0002106_abnormal_muscle_physiology1.10706118
100MP0002877_abnormal_melanocyte_morpholog1.09690660
101MP0005332_abnormal_amino_acid1.09535353
102MP0004084_abnormal_cardiac_muscle1.09419930
103MP0000569_abnormal_digit_pigmentation1.09418128
104MP0000350_abnormal_cell_proliferation1.09371691
105MP0002084_abnormal_developmental_patter1.09081718
106MP0004484_altered_response_of1.07334820
107MP0003633_abnormal_nervous_system1.06374805
108MP0001440_abnormal_grooming_behavior1.06040747
109MP0002557_abnormal_social/conspecific_i1.04380160
110MP0005381_digestive/alimentary_phenotyp1.04177688
111MP0006292_abnormal_olfactory_placode1.04005709
112MP0004185_abnormal_adipocyte_glucose1.03993362
113MP0010329_abnormal_lipoprotein_level1.02416348
114MP0000639_abnormal_adrenal_gland1.01319375
115MP0010030_abnormal_orbit_morphology0.99413536
116MP0001849_ear_inflammation0.99065274
117MP0002229_neurodegeneration0.99063077
118MP0004085_abnormal_heartbeat0.96183113
119MP0000372_irregular_coat_pigmentation0.90251445
120MP0001672_abnormal_embryogenesis/_devel0.90012786
121MP0005380_embryogenesis_phenotype0.90012786
122MP0003950_abnormal_plasma_membrane0.88033132
123MP0000678_abnormal_parathyroid_gland0.87956252
124MP0005085_abnormal_gallbladder_physiolo0.87934322
125MP0002972_abnormal_cardiac_muscle0.87933759
126MP0001915_intracranial_hemorrhage0.87628896
127MP0005410_abnormal_fertilization0.87488172
128MP0005369_muscle_phenotype0.86043921
129MP0005535_abnormal_body_temperature0.85408395
130MP0005084_abnormal_gallbladder_morpholo0.85315017
131MP0002693_abnormal_pancreas_physiology0.84964589
132MP0005448_abnormal_energy_balance0.83374307
133MP0000477_abnormal_intestine_morphology0.83129820
134MP0009764_decreased_sensitivity_to0.82535693
135MP0004742_abnormal_vestibular_system0.82508167
136MP0002019_abnormal_tumor_incidence0.82326719
137MP0000751_myopathy0.82167636
138MP0002909_abnormal_adrenal_gland0.77943308
139MP0003755_abnormal_palate_morphology0.76662368
140MP0001529_abnormal_vocalization0.76314589
141MP0002086_abnormal_extraembryonic_tissu0.75755906
142MP0004510_myositis0.75631429
143MP0004133_heterotaxia0.75427093
144MP0003631_nervous_system_phenotype0.75295191
145MP0000631_abnormal_neuroendocrine_gland0.75073562
146MP0005379_endocrine/exocrine_gland_phen0.75055966
147MP0008007_abnormal_cellular_replicative0.74203465
148MP0008875_abnormal_xenobiotic_pharmacok0.73436132
149MP0004859_abnormal_synaptic_plasticity0.72590004
150MP0003045_fibrosis0.71563786
151MP0010307_abnormal_tumor_latency0.67417455
152MP0010386_abnormal_urinary_bladder0.67095846
153MP0008058_abnormal_DNA_repair0.66540297
154MP0001663_abnormal_digestive_system0.64249269
155MP0000427_abnormal_hair_cycle0.64170758
156MP0001873_stomach_inflammation0.64115631
157MP0006072_abnormal_retinal_apoptosis0.63521255
158MP0001346_abnormal_lacrimal_gland0.63457905
159MP0005266_abnormal_metabolism0.63285797
160MP0010368_abnormal_lymphatic_system0.62548185
161MP0000566_synostosis0.57049035
162MP0003890_abnormal_embryonic-extraembry0.55988547
163MP0001905_abnormal_dopamine_level0.55690776
164MP0003984_embryonic_growth_retardation0.55123894
165MP0003698_abnormal_male_reproductive0.55095876
166MP0008995_early_reproductive_senescence0.53762042
167MP0005248_abnormal_Harderian_gland0.52724504
168MP0000613_abnormal_salivary_gland0.52671671
169MP0002932_abnormal_joint_morphology0.52458029
170MP0002876_abnormal_thyroid_physiology0.52130125
171MP0000432_abnormal_head_morphology0.51852329
172MP0004270_analgesia0.51667201
173MP0000470_abnormal_stomach_morphology0.51089657
174MP0003786_premature_aging0.51080014
175MP0002088_abnormal_embryonic_growth/wei0.50522546
176MP0005646_abnormal_pituitary_gland0.50114287
177MP0003938_abnormal_ear_development0.49881586
178MP0002080_prenatal_lethality0.49743631
179MP0004147_increased_porphyrin_level0.49071830
180MP0003119_abnormal_digestive_system0.48017479
181MP0002116_abnormal_craniofacial_bone0.47387639

Predicted human phenotypes

RankGene SetZ-score
1Male infertility (HP:0003251)8.08056307
2Papillary thyroid carcinoma (HP:0002895)4.75044819
3Facial hemangioma (HP:0000329)4.72922867
4Breast hypoplasia (HP:0003187)4.37360176
5Shawl scrotum (HP:0000049)4.19970989
6Chromsome breakage (HP:0040012)4.12821769
7Malnutrition (HP:0004395)4.01420851
8Cortical dysplasia (HP:0002539)3.98326923
9Patellar aplasia (HP:0006443)3.95275923
10Birth length less than 3rd percentile (HP:0003561)3.88476184
11Congenital stationary night blindness (HP:0007642)3.85587755
12Abnormality of the labia minora (HP:0012880)3.82247281
13Chromosomal breakage induced by crosslinking agents (HP:0003221)3.79951318
14Autoimmune thrombocytopenia (HP:0001973)3.76200559
15Capillary hemangiomas (HP:0005306)3.69348136
16Aplasia/Hypoplasia of the patella (HP:0006498)3.65539485
17Adrenal hypoplasia (HP:0000835)3.46157409
18Muscle fiber inclusion bodies (HP:0100299)3.44328608
19Nemaline bodies (HP:0003798)3.38710749
20Pancreatic cysts (HP:0001737)3.35805016
21Flat capital femoral epiphysis (HP:0003370)3.35546772
22Muscle hypertrophy of the lower extremities (HP:0008968)3.24742785
23Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.23541823
24Abnormality of midbrain morphology (HP:0002418)3.22003063
25Molar tooth sign on MRI (HP:0002419)3.22003063
26Calf muscle hypertrophy (HP:0008981)3.09942887
27Secondary amenorrhea (HP:0000869)3.07993293
28Abnormality of the fingertips (HP:0001211)3.05258068
29Pancreatic fibrosis (HP:0100732)3.03788837
30Hyperventilation (HP:0002883)3.02933716
31Lip pit (HP:0100267)2.99865415
32Nephronophthisis (HP:0000090)2.98257298
33Acanthocytosis (HP:0001927)2.95295465
34Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.95005854
35Abnormality of alanine metabolism (HP:0010916)2.95005854
36Hyperalaninemia (HP:0003348)2.95005854
37Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.93025969
38Pulmonary fibrosis (HP:0002206)2.90646387
39Rib fusion (HP:0000902)2.89332558
40Premature ovarian failure (HP:0008209)2.86905215
41Abnormality of glutamine family amino acid metabolism (HP:0010902)2.84206389
42Abnormality of the renal cortex (HP:0011035)2.83351151
43Infertility (HP:0000789)2.83127796
44True hermaphroditism (HP:0010459)2.82856144
45Type II lissencephaly (HP:0007260)2.79729049
46Combined immunodeficiency (HP:0005387)2.77646493
47Abolished electroretinogram (ERG) (HP:0000550)2.76816167
48Hypergonadotropic hypogonadism (HP:0000815)2.70323946
49Febrile seizures (HP:0002373)2.70208136
50Acute myeloid leukemia (HP:0004808)2.68230313
51Absent radius (HP:0003974)2.67875634
52Cholecystitis (HP:0001082)2.66275033
53Abnormal gallbladder physiology (HP:0012438)2.66275033
54Gaze-evoked nystagmus (HP:0000640)2.64937388
55Focal motor seizures (HP:0011153)2.64918316
56Sandal gap (HP:0001852)2.61009937
57Ileus (HP:0002595)2.60883193
58Attenuation of retinal blood vessels (HP:0007843)2.59389394
59Acute necrotizing encephalopathy (HP:0006965)2.59295344
60Aplasia/Hypoplasia of the breasts (HP:0010311)2.58279688
61Large for gestational age (HP:0001520)2.58102705
62Abnormality of the renal medulla (HP:0100957)2.57893521
63Breast aplasia (HP:0100783)2.55978432
64Abnormality of lateral ventricle (HP:0030047)2.55261263
65Arterial tortuosity (HP:0005116)2.54832304
66Absent forearm bone (HP:0003953)2.54210862
67Aplasia involving forearm bones (HP:0009822)2.54210862
68Medial flaring of the eyebrow (HP:0010747)2.53540986
69Polydipsia (HP:0001959)2.53486071
70Abnormal drinking behavior (HP:0030082)2.53486071
71Abnormality of chromosome segregation (HP:0002916)2.51445823
72Progressive cerebellar ataxia (HP:0002073)2.49730026
73Mitochondrial inheritance (HP:0001427)2.49266844
74Broad-based gait (HP:0002136)2.46090516
75Aplasia/Hypoplasia involving the musculature (HP:0001460)2.43031913
76Abnormality of small intestinal villus morphology (HP:0011472)2.41848861
77Villous atrophy (HP:0011473)2.41848861
78Progressive macrocephaly (HP:0004481)2.41151042
79Focal seizures (HP:0007359)2.39952745
80Decreased central vision (HP:0007663)2.39884994
81Thyroid carcinoma (HP:0002890)2.39515920
82Mesangial abnormality (HP:0001966)2.37800351
83Inability to walk (HP:0002540)2.34481594
84Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.32883360
85Increased CSF lactate (HP:0002490)2.31844362
86Abnormality of chromosome stability (HP:0003220)2.31792421
87Hemiparesis (HP:0001269)2.31443624
88Sparse lateral eyebrow (HP:0005338)2.30510107
89Polyphagia (HP:0002591)2.28695149
90Exercise-induced muscle cramps (HP:0003710)2.26509292
91Cystic hygroma (HP:0000476)2.25839762
92Distal arthrogryposis (HP:0005684)2.25508089
93Fair hair (HP:0002286)2.24757951
94Ketoacidosis (HP:0001993)2.23133753
95Dialeptic seizures (HP:0011146)2.23041524
963-Methylglutaconic aciduria (HP:0003535)2.22732950
97Hepatic necrosis (HP:0002605)2.21383893
98Acute encephalopathy (HP:0006846)2.21278539
99Renal cortical cysts (HP:0000803)2.20917742
100Short thumb (HP:0009778)2.20844026
101Insulin-resistant diabetes mellitus (HP:0000831)2.19415589
102Decreased circulating renin level (HP:0003351)2.19096637
103Chronic bronchitis (HP:0004469)2.18716682
104Spondylolisthesis (HP:0003302)2.18676386
105Abnormal mitochondria in muscle tissue (HP:0008316)2.17967750
106Abnormality of the phalanges of the hallux (HP:0010057)2.17902099
107Severe combined immunodeficiency (HP:0004430)2.17660940
108Pendular nystagmus (HP:0012043)2.17647758
109Oligodactyly (hands) (HP:0001180)2.16584705
110Prostate neoplasm (HP:0100787)2.15696015
111Congenital sensorineural hearing impairment (HP:0008527)2.14934720
112Decreased electroretinogram (ERG) amplitude (HP:0000654)2.14395060
113Supernumerary spleens (HP:0009799)2.12518832
114Tubular atrophy (HP:0000092)2.12116122
115Vascular tortuosity (HP:0004948)2.11772064
116Ketosis (HP:0001946)2.11169339
117Abnormality of placental membranes (HP:0011409)2.09112064
118Amniotic constriction ring (HP:0009775)2.09112064
119Type 2 muscle fiber atrophy (HP:0003554)2.07464428
120Abnormality of the proximal phalanges of the hand (HP:0009834)2.07372649
121Increased corneal curvature (HP:0100692)2.06486406
122Keratoconus (HP:0000563)2.06486406
123Aplasia/Hypoplasia of the uvula (HP:0010293)2.05441285
124Methylmalonic acidemia (HP:0002912)2.05238889
125Abnormal rod and cone electroretinograms (HP:0008323)2.05091803
126Pustule (HP:0200039)2.04253519
127Abnormality of the preputium (HP:0100587)2.04045083
128Abnormality of the 1st metacarpal (HP:0010009)2.03986056
129Hepatocellular necrosis (HP:0001404)2.02949422
130Frequent falls (HP:0002359)2.01982713
131Oligodactyly (HP:0012165)1.98931063
132Exercise-induced myalgia (HP:0003738)1.97864709
133Optic disc pallor (HP:0000543)1.97375562
134Bundle branch block (HP:0011710)1.97255248
135Muscle fiber atrophy (HP:0100295)1.97241220
136Hypobetalipoproteinemia (HP:0003563)1.96358644
137Cystic liver disease (HP:0006706)1.95009390
138Polycythemia (HP:0001901)1.93761856
139Congenital hepatic fibrosis (HP:0002612)1.93722885
140Cupped ribs (HP:0000887)1.92407368
141Clumsiness (HP:0002312)1.92382702
142Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.91840838
143Short 1st metacarpal (HP:0010034)1.91840838
144Polyuria (HP:0000103)1.91309936
145Lipid accumulation in hepatocytes (HP:0006561)1.90340635
146Gait imbalance (HP:0002141)1.90269948
147Duodenal stenosis (HP:0100867)1.89971341
148Small intestinal stenosis (HP:0012848)1.89971341
149Generalized tonic-clonic seizures (HP:0002069)1.89676790
150Type 1 muscle fiber predominance (HP:0003803)1.88956106
151Abnormality of the ileum (HP:0001549)1.88764378
152Abnormality of urine glucose concentration (HP:0011016)1.88455834
153Glycosuria (HP:0003076)1.88455834
154Potter facies (HP:0002009)1.87917292
155Facial shape deformation (HP:0011334)1.87917292
156Chronic hepatic failure (HP:0100626)1.87516958
157Primary amenorrhea (HP:0000786)1.87256526
158Methylmalonic aciduria (HP:0012120)1.87250411
159Agitation (HP:0000713)1.86094524
160Atonic seizures (HP:0010819)1.85519853
161Abnormality of the calf musculature (HP:0001430)1.84906784
162Severe muscular hypotonia (HP:0006829)1.84729028
163Progressive inability to walk (HP:0002505)1.84244442
164Absence seizures (HP:0002121)1.83694364
165Hypomagnesemia (HP:0002917)1.82956029
166Congenital, generalized hypertrichosis (HP:0004540)1.82233183
167Protruding tongue (HP:0010808)1.82200823
168Short humerus (HP:0005792)1.80415703
169Overlapping toe (HP:0001845)1.79167188
170Left ventricular hypertrophy (HP:0001712)1.79045510
171Absent speech (HP:0001344)1.78772252
172Hyperglycinuria (HP:0003108)1.78393718
173Genetic anticipation (HP:0003743)1.78144940
174Rhabdomyosarcoma (HP:0002859)1.77367071
175Thyroiditis (HP:0100646)1.76676916
176Goiter (HP:0000853)1.74755170
177Ectopic kidney (HP:0000086)1.74378850
178Abnormality of proline metabolism (HP:0010907)1.74371683
179Hydroxyprolinuria (HP:0003080)1.74371683
180Stomach cancer (HP:0012126)1.73696026
181Abnormality of the fovea (HP:0000493)1.73242812
182Lissencephaly (HP:0001339)1.73213465
183Meckel diverticulum (HP:0002245)1.73170287
184Pachygyria (HP:0001302)1.73097720
185Limb dystonia (HP:0002451)1.73032377
186Aplasia/Hypoplasia of the ulna (HP:0006495)1.72566099
187Impulsivity (HP:0100710)1.72483378
188Generalized hypopigmentation of hair (HP:0011358)1.71755513
189Tongue fasciculations (HP:0001308)1.71373131
190Poikilocytosis (HP:0004447)1.71108938
191Congenital primary aphakia (HP:0007707)1.70423219
192Myelodysplasia (HP:0002863)1.70314001
193Myoglobinuria (HP:0002913)1.69364241
194Abnormality of the distal phalanx of the thumb (HP:0009617)1.69324166
195Prolonged QT interval (HP:0001657)1.68663608
196Midline defect of the nose (HP:0004122)1.68591636
197Increased hepatocellular lipid droplets (HP:0006565)1.67873762
198Abnormality of the labia (HP:0000058)1.67803075
199Abnormal biliary tract physiology (HP:0012439)1.66412689

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K64.69501614
2LATS13.61629952
3OBSCN3.58978493
4TAOK33.54066701
5KSR23.50195330
6MUSK3.26585872
7ADRBK23.21304551
8PLK43.14192134
9LATS23.13503086
10MAP3K93.12543393
11TTK3.07661035
12ERBB43.06427948
13BRAF3.02731021
14EEF2K2.95864263
15PHKG22.83664723
16PHKG12.83664723
17BMPR1B2.79337968
18TAOK12.59530463
19DAPK22.57191107
20MAP3K132.42790385
21STK38L2.42191555
22MOS2.42156915
23RAF12.38781056
24MAP4K22.20002177
25ARAF2.18931224
26GRK12.18637892
27MAPKAPK32.08260441
28WNK31.98668770
29CDC71.97643704
30TXK1.89828877
31TIE11.89178075
32CASK1.76159061
33TLK11.72314573
34MARK11.71996473
35STK31.63124091
36INSRR1.62783325
37CDK81.62611620
38CHEK21.62272189
39ZAK1.60042595
40WNK41.55581749
41BMPR21.50573533
42STK101.50293623
43MELK1.43084902
44CDK91.42110153
45OXSR11.41021485
46PRKD21.39469068
47TYRO31.36272983
48KSR11.34774748
49BCKDK1.33957574
50NTRK31.29000748
51MAP2K61.27553087
52NEK21.26405168
53PAK61.18179915
54FRK1.18065960
55PAK31.16679983
56PLK11.16128549
57MAP3K81.13683985
58PRKD31.11248485
59GRK71.07479055
60PIK3CG1.06793694
61TNIK1.06570133
62STK391.04497354
63ADRBK11.02564571
64PRKCE1.00094740
65TRPM70.99621539
66MAPKAPK50.97535502
67CAMKK20.97359729
68PKN10.97250670
69PRKCG0.97097307
70PRKAA20.96466927
71DYRK20.94936029
72DMPK0.91809819
73TGFBR10.91264001
74PTK2B0.88657698
75CAMK10.83260576
76PINK10.81419622
77ACVR1B0.81014501
78MAP3K40.80631318
79MAPK130.80074994
80PLK20.78896177
81FGR0.78598213
82IKBKB0.77066290
83PRKAA10.76210812
84AURKB0.74850080
85NUAK10.74376304
86EPHA40.73923279
87TNK20.72761568
88RPS6KB20.72603095
89PIK3CA0.69767381
90DDR20.66219021
91MAPK110.65878413
92MAP3K110.65807287
93CAMK2D0.63534028
94PRKACA0.63414962
95PRKG10.61714830
96ABL20.59587464
97CDK70.58893384
98GRK50.58766321
99KIT0.58664819
100LIMK10.58156831
101TEC0.57149417
102CSNK1G10.57120776
103STK240.55451240
104CAMK2G0.54357109
105MAPK120.54104026
106MARK20.53944209
107SGK4940.53708163
108SGK2230.53708163
109MAP2K70.53516127
110STK110.52983867
111IKBKE0.52596005
112AURKA0.51594508
113CAMK40.50450557
114STK380.50367283
115MAP3K50.49297739
116AKT30.49253940
117PRKCQ0.49175835
118SYK0.47322804
119MAP3K70.45115503
120MATK0.44902524
121PRKCA0.43121472
122LMTK20.42980953
123CSNK1A10.42812244
124ICK0.42747363
125CAMK2B0.42742849
126PRKCZ0.42670171
127MST40.42316297
128CHUK0.41706785
129RPS6KA50.41467311
130MAP3K10.41170411
131RET0.40076455
132ATM0.37842615
133MAPK150.37154875
134CHEK10.36667042
135MAP2K10.36520781
136SGK10.35927940
137VRK10.35006473
138MAP2K40.34641476
139SIK20.34537963
140ERBB30.34261561
141MST1R0.32510044
142FER0.32036593
143PRKACG0.31659197
144EPHA30.31506530
145CDK50.31440909
146DYRK1A0.30872138
147NLK0.30664570
148PRKG20.30194827
149IRAK10.29935643
150ITK0.29905661
151CDK120.29809073
152NME10.29368440
153PRKCI0.28659455
154NEK90.26358853
155CAMK2A0.26304017
156ABL10.25610671
157CSNK1G20.24628561
158PIM10.24109107
159NEK10.23983606
160PLK30.23044821
161CSNK1G30.22709500
162CDK40.22531177
163SGK20.21225853
164CDK20.20204983
165PAK10.20068915
166CDK30.19796155
167CDK60.19738289
168CDK10.19125916
169HIPK20.17407811
170BMX0.16903829
171RIPK10.16624361
172TESK20.16133544
173BUB10.16052600
174NTRK20.16040764
175CDK150.10444578
176JAK30.10375721

Predicted pathways (KEGG)

RankGene SetZ-score
1Cell cycle_Homo sapiens_hsa041103.85903162
2Fat digestion and absorption_Homo sapiens_hsa049753.60169066
3Circadian rhythm_Homo sapiens_hsa047103.04640715
4RNA degradation_Homo sapiens_hsa030183.02305420
5Mineral absorption_Homo sapiens_hsa049782.80144026
6Phototransduction_Homo sapiens_hsa047442.62283568
7Basal transcription factors_Homo sapiens_hsa030222.47240512
8Butanoate metabolism_Homo sapiens_hsa006502.44908547
9Vitamin digestion and absorption_Homo sapiens_hsa049772.44508506
10Renin-angiotensin system_Homo sapiens_hsa046142.35818504
11Oxidative phosphorylation_Homo sapiens_hsa001902.32967493
12Tryptophan metabolism_Homo sapiens_hsa003802.29106368
13p53 signaling pathway_Homo sapiens_hsa041152.21271351
14Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.15260142
15Folate biosynthesis_Homo sapiens_hsa007902.11952119
16Primary bile acid biosynthesis_Homo sapiens_hsa001202.07342787
17Cardiac muscle contraction_Homo sapiens_hsa042602.06554672
18TGF-beta signaling pathway_Homo sapiens_hsa043502.04936681
19Pancreatic cancer_Homo sapiens_hsa052122.04425583
20Base excision repair_Homo sapiens_hsa034102.04158320
21* Ovarian steroidogenesis_Homo sapiens_hsa049132.02661329
22Nicotine addiction_Homo sapiens_hsa050332.02261703
23Nitrogen metabolism_Homo sapiens_hsa009101.99501162
24* Linoleic acid metabolism_Homo sapiens_hsa005911.93719975
25Oocyte meiosis_Homo sapiens_hsa041141.89516591
26Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.88411584
27Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.76420370
28Homologous recombination_Homo sapiens_hsa034401.75460443
29Parkinsons disease_Homo sapiens_hsa050121.73005378
30Dorso-ventral axis formation_Homo sapiens_hsa043201.72778891
31Fanconi anemia pathway_Homo sapiens_hsa034601.71086109
32Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.67440654
33Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.63640536
34Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.62287880
35Vitamin B6 metabolism_Homo sapiens_hsa007501.59241641
36Mismatch repair_Homo sapiens_hsa034301.55652333
37* alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.53725548
38Insulin secretion_Homo sapiens_hsa049111.52692244
39Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.52662312
40Morphine addiction_Homo sapiens_hsa050321.49376546
41DNA replication_Homo sapiens_hsa030301.47555817
42Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.42590894
43Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.39316828
44GABAergic synapse_Homo sapiens_hsa047271.36966044
45Circadian entrainment_Homo sapiens_hsa047131.36274229
46Intestinal immune network for IgA production_Homo sapiens_hsa046721.34339298
47Colorectal cancer_Homo sapiens_hsa052101.31032837
48MicroRNAs in cancer_Homo sapiens_hsa052061.29328107
49ABC transporters_Homo sapiens_hsa020101.29277177
50Fatty acid biosynthesis_Homo sapiens_hsa000611.29155067
51Propanoate metabolism_Homo sapiens_hsa006401.28832037
52Alzheimers disease_Homo sapiens_hsa050101.28481228
53Adherens junction_Homo sapiens_hsa045201.28194727
54Chemical carcinogenesis_Homo sapiens_hsa052041.28167425
55Peroxisome_Homo sapiens_hsa041461.27281624
56Protein digestion and absorption_Homo sapiens_hsa049741.25160509
57Retinol metabolism_Homo sapiens_hsa008301.23998401
58Prolactin signaling pathway_Homo sapiens_hsa049171.23263644
59Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.22677139
60Taste transduction_Homo sapiens_hsa047421.21505413
61Collecting duct acid secretion_Homo sapiens_hsa049661.20508268
62Thyroid cancer_Homo sapiens_hsa052161.19984810
63Olfactory transduction_Homo sapiens_hsa047401.19770292
64Steroid hormone biosynthesis_Homo sapiens_hsa001401.19572531
65beta-Alanine metabolism_Homo sapiens_hsa004101.18867680
66Carbohydrate digestion and absorption_Homo sapiens_hsa049731.18074451
67Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.13456928
68Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.12903664
69Hippo signaling pathway_Homo sapiens_hsa043901.12738996
70Calcium signaling pathway_Homo sapiens_hsa040201.11829778
71RNA transport_Homo sapiens_hsa030131.11523104
72Bladder cancer_Homo sapiens_hsa052191.10064491
73Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.08301911
74Arginine and proline metabolism_Homo sapiens_hsa003301.06925192
75Bile secretion_Homo sapiens_hsa049761.04148321
76Type I diabetes mellitus_Homo sapiens_hsa049401.03979075
77Asthma_Homo sapiens_hsa053101.03802291
78* Glutamatergic synapse_Homo sapiens_hsa047241.03779501
79Nucleotide excision repair_Homo sapiens_hsa034201.03288949
80Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.03147578
81Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.02694509
82Non-homologous end-joining_Homo sapiens_hsa034501.01267895
83* GnRH signaling pathway_Homo sapiens_hsa049121.00675233
84* Serotonergic synapse_Homo sapiens_hsa047261.00263823
85Selenocompound metabolism_Homo sapiens_hsa004500.99875871
86Salivary secretion_Homo sapiens_hsa049700.99243288
87* Choline metabolism in cancer_Homo sapiens_hsa052310.98823316
88Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.98272650
89Fatty acid degradation_Homo sapiens_hsa000710.97225069
90Maturity onset diabetes of the young_Homo sapiens_hsa049500.95330955
91Glutathione metabolism_Homo sapiens_hsa004800.93598522
92Glycerolipid metabolism_Homo sapiens_hsa005610.92878124
93Synaptic vesicle cycle_Homo sapiens_hsa047210.92025670
94Histidine metabolism_Homo sapiens_hsa003400.90216778
95Caffeine metabolism_Homo sapiens_hsa002320.89857282
96Rheumatoid arthritis_Homo sapiens_hsa053230.89342587
97Sphingolipid metabolism_Homo sapiens_hsa006000.85723826
98* Arachidonic acid metabolism_Homo sapiens_hsa005900.85379119
99Huntingtons disease_Homo sapiens_hsa050160.84305708
100Protein export_Homo sapiens_hsa030600.84138147
101Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.84133070
102Regulation of autophagy_Homo sapiens_hsa041400.82635884
103Endometrial cancer_Homo sapiens_hsa052130.82221788
104Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.81992954
105Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.81631677
106Galactose metabolism_Homo sapiens_hsa000520.79074316
107Allograft rejection_Homo sapiens_hsa053300.76767680
108mTOR signaling pathway_Homo sapiens_hsa041500.76237277
109* Glycerophospholipid metabolism_Homo sapiens_hsa005640.75116602
110Notch signaling pathway_Homo sapiens_hsa043300.74187492
111Renin secretion_Homo sapiens_hsa049240.74160125
112Pentose and glucuronate interconversions_Homo sapiens_hsa000400.74111499
113* Oxytocin signaling pathway_Homo sapiens_hsa049210.72364046
114Starch and sucrose metabolism_Homo sapiens_hsa005000.72340749
115Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.71813171
116Gastric acid secretion_Homo sapiens_hsa049710.70560053
117Cysteine and methionine metabolism_Homo sapiens_hsa002700.70547238
118Renal cell carcinoma_Homo sapiens_hsa052110.70482623
119Thyroid hormone synthesis_Homo sapiens_hsa049180.69560980
120Graft-versus-host disease_Homo sapiens_hsa053320.69350699
121Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.69138102
122Small cell lung cancer_Homo sapiens_hsa052220.68704351
123Amphetamine addiction_Homo sapiens_hsa050310.68503005
124* Ether lipid metabolism_Homo sapiens_hsa005650.68447457
125Dopaminergic synapse_Homo sapiens_hsa047280.68175874
126FoxO signaling pathway_Homo sapiens_hsa040680.67309213
127* Vascular smooth muscle contraction_Homo sapiens_hsa042700.67212557
128Dilated cardiomyopathy_Homo sapiens_hsa054140.66463180
129SNARE interactions in vesicular transport_Homo sapiens_hsa041300.65215539
130Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.64549271
131Autoimmune thyroid disease_Homo sapiens_hsa053200.64142089
132Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.62894168
133Arginine biosynthesis_Homo sapiens_hsa002200.62547518
134Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.62205186
135RNA polymerase_Homo sapiens_hsa030200.61856232
136Tight junction_Homo sapiens_hsa045300.61220079
137Chronic myeloid leukemia_Homo sapiens_hsa052200.60368320
138Shigellosis_Homo sapiens_hsa051310.59799772
139Hepatitis B_Homo sapiens_hsa051610.59419269
140Sulfur metabolism_Homo sapiens_hsa009200.58445773
141Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.58180697
142Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.57356202
143Cocaine addiction_Homo sapiens_hsa050300.55906101
144Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.55764184
145mRNA surveillance pathway_Homo sapiens_hsa030150.55647061
146Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.53651118
147Non-small cell lung cancer_Homo sapiens_hsa052230.53153278
148cAMP signaling pathway_Homo sapiens_hsa040240.51767288
149Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.48843566
150* Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.48453699
151Longevity regulating pathway - mammal_Homo sapiens_hsa042110.48327283
152Transcriptional misregulation in cancer_Homo sapiens_hsa052020.48158344
153Purine metabolism_Homo sapiens_hsa002300.47448396
154Thyroid hormone signaling pathway_Homo sapiens_hsa049190.47360247
155* Metabolic pathways_Homo sapiens_hsa011000.46543524
156Fatty acid metabolism_Homo sapiens_hsa012120.44505505
157Cholinergic synapse_Homo sapiens_hsa047250.43672509
158Aldosterone synthesis and secretion_Homo sapiens_hsa049250.43444344
159ErbB signaling pathway_Homo sapiens_hsa040120.42803255
160Complement and coagulation cascades_Homo sapiens_hsa046100.41620131
161Lysine degradation_Homo sapiens_hsa003100.41242816
162Prostate cancer_Homo sapiens_hsa052150.40461547
163Sphingolipid signaling pathway_Homo sapiens_hsa040710.39481746
164PPAR signaling pathway_Homo sapiens_hsa033200.39067115
165Herpes simplex infection_Homo sapiens_hsa051680.38291304
166Fructose and mannose metabolism_Homo sapiens_hsa000510.36506909
167Biosynthesis of amino acids_Homo sapiens_hsa012300.36233098
168Regulation of actin cytoskeleton_Homo sapiens_hsa048100.35816487
169Estrogen signaling pathway_Homo sapiens_hsa049150.34114888
170Pyrimidine metabolism_Homo sapiens_hsa002400.33205624
171* VEGF signaling pathway_Homo sapiens_hsa043700.32938459
172Inositol phosphate metabolism_Homo sapiens_hsa005620.31959273
173Hedgehog signaling pathway_Homo sapiens_hsa043400.30561841
174Wnt signaling pathway_Homo sapiens_hsa043100.29155156
175Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.26920594
176Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.26176250
177Gap junction_Homo sapiens_hsa045400.25391121
178Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.22588549
179Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.22567005

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