PLA2G4D

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The phospholipase A2 enzyme family, including PLA2G4D, catalyze the hydrolysis of glycerophospholipids at the sn-2 position and then liberate free fatty acids and lysophospholipids (Chiba et al., 2004 [PubMed 14709560]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1establishment of skin barrier (GO:0061436)7.73232901
2mitotic sister chromatid cohesion (GO:0007064)6.98962899
3endocrine hormone secretion (GO:0060986)6.74643089
4mitotic chromosome condensation (GO:0007076)6.50734117
5piRNA metabolic process (GO:0034587)6.38264472
6regulation of attachment of spindle microtubules to kinetochore (GO:0051988)6.19417553
7regulation of water loss via skin (GO:0033561)6.15957670
8keratinocyte differentiation (GO:0030216)6.13111504
9regulation of female gonad development (GO:2000194)5.56339073
10phenol-containing compound catabolic process (GO:0019336)5.49346554
11* phosphatidylinositol acyl-chain remodeling (GO:0036149)5.30496836
12regulation of cardioblast proliferation (GO:0003264)5.11453012
13regulation of secondary heart field cardioblast proliferation (GO:0003266)5.11453012
14mitotic sister chromatid segregation (GO:0000070)5.07647660
15sister chromatid segregation (GO:0000819)4.84028201
16detection of bacterium (GO:0016045)4.68479447
17negative regulation of retinoic acid receptor signaling pathway (GO:0048387)4.65145879
18sympathetic nervous system development (GO:0048485)4.64209906
19epidermal cell differentiation (GO:0009913)4.57238805
20mitotic metaphase plate congression (GO:0007080)4.52036470
21multicellular organism reproduction (GO:0032504)4.43987365
22attachment of spindle microtubules to kinetochore (GO:0008608)4.43502850
23* phosphatidylserine acyl-chain remodeling (GO:0036150)4.41010788
24long-chain fatty acid biosynthetic process (GO:0042759)4.40070789
25protein localization to kinetochore (GO:0034501)4.27725915
26hair cycle (GO:0042633)4.25286288
27molting cycle (GO:0042303)4.25286288
28chromosome condensation (GO:0030261)4.22857372
29histone H2A monoubiquitination (GO:0035518)4.19772162
30protein localization to chromosome, centromeric region (GO:0071459)4.19368411
31thyroid gland development (GO:0030878)4.16557609
32negative regulation of smooth muscle cell differentiation (GO:0051151)4.14547413
33negative regulation of histone methylation (GO:0031061)4.11461306
34behavioral response to ethanol (GO:0048149)4.04898112
35L-fucose catabolic process (GO:0042355)4.03898316
36fucose catabolic process (GO:0019317)4.03898316
37L-fucose metabolic process (GO:0042354)4.03898316
38mating behavior (GO:0007617)3.99422564
39thyroid hormone generation (GO:0006590)3.98110283
40sister chromatid cohesion (GO:0007062)3.95894746
41* phosphatidylethanolamine acyl-chain remodeling (GO:0036152)3.95728581
42regulation of transforming growth factor beta2 production (GO:0032909)3.95476972
43desmosome organization (GO:0002934)3.94610940
44protein K6-linked ubiquitination (GO:0085020)3.93061885
45metaphase plate congression (GO:0051310)3.92485334
46microtubule depolymerization (GO:0007019)3.91875545
47ganglion development (GO:0061548)3.87764457
48male meiosis (GO:0007140)3.86918168
49keratinocyte development (GO:0003334)3.84383452
50oocyte maturation (GO:0001556)3.82008682
51detection of light stimulus involved in sensory perception (GO:0050962)3.80103738
52detection of light stimulus involved in visual perception (GO:0050908)3.80103738
53multicellular organismal water homeostasis (GO:0050891)3.79330360
54detection of other organism (GO:0098543)3.77336380
55tryptophan catabolic process (GO:0006569)3.77028484
56indole-containing compound catabolic process (GO:0042436)3.77028484
57indolalkylamine catabolic process (GO:0046218)3.77028484
58growth hormone receptor signaling pathway (GO:0060396)3.76238903
59detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.75350393
60regulation of meiosis (GO:0040020)3.73902521
61histone H2A ubiquitination (GO:0033522)3.73574855
62neurotransmitter catabolic process (GO:0042135)3.71405023
63protein K11-linked deubiquitination (GO:0035871)3.70098911
64epidermis development (GO:0008544)3.69617078
65meiotic cell cycle (GO:0051321)3.66590953
66myoblast migration (GO:0051451)3.63586443
67kynurenine metabolic process (GO:0070189)3.63344078
68receptor guanylyl cyclase signaling pathway (GO:0007168)3.62667963
69epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.60677423
70indolalkylamine metabolic process (GO:0006586)3.59540766
71platelet dense granule organization (GO:0060155)3.57994746
72DNA methylation involved in gamete generation (GO:0043046)3.54358824
73chromosome segregation (GO:0007059)3.52728312
74reproduction (GO:0000003)3.52669727
75keratinocyte proliferation (GO:0043616)3.52138656
76regulation of retinoic acid receptor signaling pathway (GO:0048385)3.49751763
77DNA damage induced protein phosphorylation (GO:0006975)3.48863572
78negative regulation of meiosis (GO:0045835)3.47869648
79regulation of exit from mitosis (GO:0007096)3.46170415
80water homeostasis (GO:0030104)3.45120912
81* phosphatidylcholine acyl-chain remodeling (GO:0036151)3.44248881
82peptide cross-linking (GO:0018149)3.41269652
83behavioral response to nicotine (GO:0035095)3.39718655
84thyroid hormone metabolic process (GO:0042403)3.38938577
85histone exchange (GO:0043486)3.35757312
86DNA packaging (GO:0006323)3.34680936
87protein localization to chromosome (GO:0034502)3.34417063
88epithelial cilium movement (GO:0003351)3.32789566
89photoreceptor cell maintenance (GO:0045494)3.28701173
90tryptophan metabolic process (GO:0006568)3.26681747
91regulation of chromosome segregation (GO:0051983)3.26174309
92regulation of meiosis I (GO:0060631)3.25656165
93female gamete generation (GO:0007292)3.23736684
94response to pheromone (GO:0019236)3.23668331
95establishment of chromosome localization (GO:0051303)3.23465636
96oocyte development (GO:0048599)3.23383122
97regulation of sister chromatid cohesion (GO:0007063)3.22358448
98parturition (GO:0007567)3.22326988
99monoubiquitinated protein deubiquitination (GO:0035520)3.22163098
100inner ear receptor cell development (GO:0060119)3.20476510
101CENP-A containing nucleosome assembly (GO:0034080)3.20059205
102microtubule severing (GO:0051013)3.19815925
103establishment of spindle localization (GO:0051293)3.19224997
104cellular response to growth hormone stimulus (GO:0071378)3.19074120
105gene silencing by RNA (GO:0031047)3.17818526
106fusion of sperm to egg plasma membrane (GO:0007342)3.17732954
107DNA replication-independent nucleosome assembly (GO:0006336)3.17101310
108DNA replication-independent nucleosome organization (GO:0034724)3.17101310
109chromatin remodeling at centromere (GO:0031055)3.16028116
110spindle checkpoint (GO:0031577)3.15556651
111acrosome assembly (GO:0001675)3.14131649
112auditory receptor cell stereocilium organization (GO:0060088)3.13866656
113axoneme assembly (GO:0035082)3.12367884
114proline transport (GO:0015824)3.07037134
115cornea development in camera-type eye (GO:0061303)3.04938775
116kinetochore organization (GO:0051383)3.04485143
117DNA replication checkpoint (GO:0000076)3.04066708
118cilium or flagellum-dependent cell motility (GO:0001539)3.00984996
119reflex (GO:0060004)3.00687666
120regulation of dopamine uptake involved in synaptic transmission (GO:0051584)3.00658800
121regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)3.00658800
122regulation of meiotic cell cycle (GO:0051445)2.99762031
123regulation of spindle organization (GO:0090224)2.99487734
124meiotic nuclear division (GO:0007126)2.94392062
125* phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.93950424
126meiotic chromosome segregation (GO:0045132)2.93695437
127cellular ketone body metabolic process (GO:0046950)2.93671689
128regulation of centriole replication (GO:0046599)2.93175362
129regulation of DNA methylation (GO:0044030)2.92927558
130negative regulation of meiotic cell cycle (GO:0051447)2.91838677
131reciprocal DNA recombination (GO:0035825)2.91345865
132reciprocal meiotic recombination (GO:0007131)2.91345865
133positive regulation of male gonad development (GO:2000020)2.90513399
134gamma-aminobutyric acid transport (GO:0015812)2.90342047
135negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.90109384
136synaptonemal complex assembly (GO:0007130)2.89353888
137negative regulation of organelle assembly (GO:1902116)2.88473077
138notochord development (GO:0030903)2.88068743
139synaptonemal complex organization (GO:0070193)2.87162959
140base-excision repair, AP site formation (GO:0006285)2.86312924
141regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.85805078
142DNA deamination (GO:0045006)2.85641579
143regulation of T cell chemotaxis (GO:0010819)2.80778835
144positive regulation of T cell chemotaxis (GO:0010820)2.80778835
145neural tube formation (GO:0001841)2.79788885
146regulation of mitotic spindle organization (GO:0060236)2.79388338
147inner ear receptor stereocilium organization (GO:0060122)2.79270271
148negative regulation of cytosolic calcium ion concentration (GO:0051481)2.79118645
149cytoplasmic mRNA processing body assembly (GO:0033962)2.78698406
150ketone body metabolic process (GO:1902224)2.76827517
151negative regulation of mast cell activation (GO:0033004)2.74952714
152rRNA catabolic process (GO:0016075)2.74263519
153ectoderm development (GO:0007398)2.70757393
154indole-containing compound metabolic process (GO:0042430)2.70226855
155water-soluble vitamin biosynthetic process (GO:0042364)2.67531087
156regulation of natural killer cell differentiation (GO:0032823)2.67367840
157sulfation (GO:0051923)2.63298396
158preassembly of GPI anchor in ER membrane (GO:0016254)2.62902623
159atrial cardiac muscle cell action potential (GO:0086014)2.59287703
160respiratory chain complex IV assembly (GO:0008535)2.57788684
161transepithelial transport (GO:0070633)2.57649414
162retinal cone cell development (GO:0046549)2.56763361
163adaptation of signaling pathway (GO:0023058)2.56245670
164regulation of nuclear cell cycle DNA replication (GO:0033262)2.53381065
165glycerophospholipid catabolic process (GO:0046475)2.53229283
166synapsis (GO:0007129)2.52650015
167* phospholipid catabolic process (GO:0009395)2.52342999
168cilium morphogenesis (GO:0060271)2.52152091
169G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.51768844
170gap junction assembly (GO:0016264)2.50426154
171negative regulation of systemic arterial blood pressure (GO:0003085)2.48146443
172intermediate filament-based process (GO:0045103)2.43978750
173male meiosis I (GO:0007141)2.43624140
174regulation of mesoderm development (GO:2000380)2.42183590
175neuronal action potential (GO:0019228)2.42021067
176photoreceptor cell development (GO:0042461)2.41568399
177ceramide biosynthetic process (GO:0046513)2.40658909
178regulation of rhodopsin mediated signaling pathway (GO:0022400)2.40345351
179one-carbon compound transport (GO:0019755)2.38283139
180intermediate filament cytoskeleton organization (GO:0045104)2.37517118
181cellular biogenic amine catabolic process (GO:0042402)2.37091899
182amine catabolic process (GO:0009310)2.37091899
183regulation of cilium movement (GO:0003352)2.37091289
1843-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.36417490
185purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.36417490
186rhodopsin mediated signaling pathway (GO:0016056)2.35158465
187lipoxygenase pathway (GO:0019372)2.34771332
188cytochrome complex assembly (GO:0017004)2.33229804
189serotonin metabolic process (GO:0042428)2.32570510
190keratinization (GO:0031424)11.3505024

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse6.59773678
2E2F7_22180533_ChIP-Seq_HELA_Human5.94981790
3FOXM1_23109430_ChIP-Seq_U2OS_Human5.61794096
4VDR_22108803_ChIP-Seq_LS180_Human3.36237236
5ZNF274_21170338_ChIP-Seq_K562_Hela3.35260711
6AR_21909140_ChIP-Seq_LNCAP_Human3.21286900
7SALL1_21062744_ChIP-ChIP_HESCs_Human3.12788158
8GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.05167917
9GBX2_23144817_ChIP-Seq_PC3_Human2.87505312
10EZH2_22144423_ChIP-Seq_EOC_Human2.62517766
11KAP1_22055183_ChIP-Seq_ESCs_Mouse2.54402282
12IGF1R_20145208_ChIP-Seq_DFB_Human2.47863215
13FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.42274530
14MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.34605159
15GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.23909044
16ZNF263_19887448_ChIP-Seq_K562_Human2.20206164
17ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.17533424
18P300_19829295_ChIP-Seq_ESCs_Human2.03455157
19PCGF2_27294783_Chip-Seq_ESCs_Mouse1.90056529
20ER_23166858_ChIP-Seq_MCF-7_Human1.83538220
21RUNX1_26923725_Chip-Seq_HPCs_Mouse1.77337876
22FLI1_27457419_Chip-Seq_LIVER_Mouse1.75374549
23TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.70803994
24PIAS1_25552417_ChIP-Seq_VCAP_Human1.70405674
25E2F4_17652178_ChIP-ChIP_JURKAT_Human1.70111965
26MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.69806123
27* BCAT_22108803_ChIP-Seq_LS180_Human1.69681428
28RNF2_27304074_Chip-Seq_NSC_Mouse1.68867875
29FUS_26573619_Chip-Seq_HEK293_Human1.64601394
30KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.64258183
31TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.64257671
32* NMYC_18555785_Chip-Seq_ESCs_Mouse1.61514214
33* CTCF_18555785_Chip-Seq_ESCs_Mouse1.60315589
34AR_25329375_ChIP-Seq_VCAP_Human1.59955498
35ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.58567304
36* SOX2_18555785_Chip-Seq_ESCs_Mouse1.57630626
37OCT4_18555785_Chip-Seq_ESCs_Mouse1.56561844
38* CMYC_18555785_Chip-Seq_ESCs_Mouse1.55372431
39NANOG_18555785_Chip-Seq_ESCs_Mouse1.55355027
40CBP_20019798_ChIP-Seq_JUKART_Human1.54951111
41IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.54951111
42EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.54303880
43ESRRB_18555785_Chip-Seq_ESCs_Mouse1.54259018
44EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.53033280
45* TCF4_22108803_ChIP-Seq_LS180_Human1.51579701
46AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.51365327
47* KLF4_18555785_Chip-Seq_ESCs_Mouse1.50925450
48EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.50046286
49FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.49260210
50* STAT3_18555785_Chip-Seq_ESCs_Mouse1.49232677
51TCF4_23295773_ChIP-Seq_U87_Human1.49232035
52KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.48684313
53NFE2_27457419_Chip-Seq_LIVER_Mouse1.48143830
54NR3C1_21868756_ChIP-Seq_MCF10A_Human1.47123938
55ZFX_18555785_Chip-Seq_ESCs_Mouse1.46679819
56SUZ12_18555785_Chip-Seq_ESCs_Mouse1.45403361
57MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.43818725
58* SMAD1_18555785_Chip-Seq_ESCs_Mouse1.43772048
59CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.43504046
60SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.42474346
61NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.42160505
62MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.41933759
63FOXA1_25329375_ChIP-Seq_VCAP_Human1.41457403
64FOXA1_27270436_Chip-Seq_PROSTATE_Human1.41457403
65* P300_18555785_Chip-Seq_ESCs_Mouse1.41111960
66POU3F2_20337985_ChIP-ChIP_501MEL_Human1.41011139
67SMAD3_21741376_ChIP-Seq_EPCs_Human1.40469886
68EWS_26573619_Chip-Seq_HEK293_Human1.40352507
69ZFP57_27257070_Chip-Seq_ESCs_Mouse1.39481025
70GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.37540716
71FOXA1_21572438_ChIP-Seq_LNCaP_Human1.36534699
72MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.36214822
73SOX2_19829295_ChIP-Seq_ESCs_Human1.35994735
74NANOG_19829295_ChIP-Seq_ESCs_Human1.35994735
75NOTCH1_21737748_ChIP-Seq_TLL_Human1.35860116
76SUZ12_27294783_Chip-Seq_NPCs_Mouse1.35574479
77E2F1_18555785_Chip-Seq_ESCs_Mouse1.34733116
78RUNX1_27457419_Chip-Seq_LIVER_Mouse1.33222627
79NCOR_22424771_ChIP-Seq_293T_Human1.32643867
80SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.31601413
81AR_20517297_ChIP-Seq_VCAP_Human1.31597863
82SMAD_19615063_ChIP-ChIP_OVARY_Human1.30866732
83TOP2B_26459242_ChIP-Seq_MCF-7_Human1.30505767
84EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.30287359
85HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.29702488
86ESR1_20079471_ChIP-ChIP_T-47D_Human1.28220904
87TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.25937637
88GATA1_26923725_Chip-Seq_HPCs_Mouse1.24802859
89PRDM14_20953172_ChIP-Seq_ESCs_Human1.24265203
90SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.24111206
91GATA3_21878914_ChIP-Seq_MCF-7_Human1.23707153
92TAF15_26573619_Chip-Seq_HEK293_Human1.23387297
93FLI1_21867929_ChIP-Seq_TH2_Mouse1.23124838
94AUTS2_25519132_ChIP-Seq_293T-REX_Human1.22866662
95RUNX2_22187159_ChIP-Seq_PCA_Human1.22298685
96P53_22387025_ChIP-Seq_ESCs_Mouse1.22019637
97UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.21552422
98PU1_27457419_Chip-Seq_LIVER_Mouse1.21080583
99SMAD4_21741376_ChIP-Seq_EPCs_Human1.21004864
100TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19845394
101POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.19845394
102TP53_22573176_ChIP-Seq_HFKS_Human1.19816186
103STAT6_21828071_ChIP-Seq_BEAS2B_Human1.17882814
104SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.17701684
105EZH2_27294783_Chip-Seq_NPCs_Mouse1.17696396
106CDX2_19796622_ChIP-Seq_MESCs_Mouse1.17583350
107IRF1_19129219_ChIP-ChIP_H3396_Human1.16943784
108STAT3_23295773_ChIP-Seq_U87_Human1.16360946
109TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.15813881
110HTT_18923047_ChIP-ChIP_STHdh_Human1.14758841
111HOXB7_26014856_ChIP-Seq_BT474_Human1.14728990
112CTBP2_25329375_ChIP-Seq_LNCAP_Human1.13664530
113GF1B_26923725_Chip-Seq_HPCs_Mouse1.13293230
114RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.13197128
115AR_21572438_ChIP-Seq_LNCaP_Human1.12648546
116SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.11952692
117TBL1_22424771_ChIP-Seq_293T_Human1.11903574
118PKCTHETA_26484144_Chip-Seq_BREAST_Human1.11608574
119BMI1_23680149_ChIP-Seq_NPCS_Mouse1.11279895
120GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.10671039
121OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.09740868
122EGR1_23403033_ChIP-Seq_LIVER_Mouse1.09607182
123TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.09143894
124ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.07798610
125E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.07580314
126RXR_22108803_ChIP-Seq_LS180_Human1.07099532
127OCT4_21477851_ChIP-Seq_ESCs_Mouse1.07011743
128MYC_18940864_ChIP-ChIP_HL60_Human1.06331523
129TP63_19390658_ChIP-ChIP_HaCaT_Human1.06275761
130ETV2_25802403_ChIP-Seq_MESCs_Mouse1.05927171
131NFYA_21822215_ChIP-Seq_K562_Human1.05375988
132TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.05321735
133CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.04949618
134* TP63_23658742_ChIP-Seq_EP156T_Human1.04602594
135CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.02324801
136SMAD4_21799915_ChIP-Seq_A2780_Human1.01421741
137E2F1_21310950_ChIP-Seq_MCF-7_Human1.00907626
138PCGF2_27294783_Chip-Seq_NPCs_Mouse0.99920551
139KDM2B_26808549_Chip-Seq_REH_Human0.97562241
140CJUN_26792858_Chip-Seq_BT549_Human0.97238715
141CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.97213979
142CDX2_22108803_ChIP-Seq_LS180_Human0.97087268
143CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.94632428
144FOXM1_26456572_ChIP-Seq_MCF-7_Human0.94621848
145PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.94116344
146NR3C1_23031785_ChIP-Seq_PC12_Mouse0.91642615
147TAL1_26923725_Chip-Seq_HPCs_Mouse0.91444266
148GF1_26923725_Chip-Seq_HPCs_Mouse0.90784293
149CTBP1_25329375_ChIP-Seq_LNCAP_Human0.90420320
150PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.89899758
151STAT1_17558387_ChIP-Seq_HELA_Human0.89814318
152KLF5_20875108_ChIP-Seq_MESCs_Mouse0.89684173
153GATA3_21867929_ChIP-Seq_TH1_Mouse0.89635551
154CBX2_27304074_Chip-Seq_ESCs_Mouse0.89553988
155* FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.88840409
156CRX_20693478_ChIP-Seq_RETINA_Mouse0.88084047

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005187_abnormal_penis_morphology5.37223934
2MP0002822_catalepsy4.60397105
3MP0003315_abnormal_perineum_morphology4.52124514
4MP0004885_abnormal_endolymph4.09490027
5MP0005275_abnormal_skin_tensile4.07857152
6MP0002876_abnormal_thyroid_physiology4.03622284
7MP0000569_abnormal_digit_pigmentation3.17162865
8MP0005501_abnormal_skin_physiology3.11092748
9MP0002102_abnormal_ear_morphology3.05346848
10MP0003718_maternal_effect2.99345807
11MP0002638_abnormal_pupillary_reflex2.93170563
12MP0008877_abnormal_DNA_methylation2.85960377
13MP0002138_abnormal_hepatobiliary_system2.80892062
14MP0003878_abnormal_ear_physiology2.60975759
15MP0005377_hearing/vestibular/ear_phenot2.60975759
16MP0001929_abnormal_gametogenesis2.47653127
17MP0003011_delayed_dark_adaptation2.44175508
18MP0003195_calcinosis2.38528084
19MP0005551_abnormal_eye_electrophysiolog2.33236147
20MP0004185_abnormal_adipocyte_glucose2.19101292
21MP0010094_abnormal_chromosome_stability2.18450590
22MP0000647_abnormal_sebaceous_gland2.17984692
23MP0003123_paternal_imprinting2.12977522
24MP0002210_abnormal_sex_determination2.10388678
25MP0003693_abnormal_embryo_hatching2.08333360
26MP0002095_abnormal_skin_pigmentation2.01577467
27MP0005174_abnormal_tail_pigmentation2.00028517
28MP0000579_abnormal_nail_morphology2.00024956
29MP0005451_abnormal_body_composition1.99527356
30MP0005410_abnormal_fertilization1.92551058
31MP0000653_abnormal_sex_gland1.91300410
32MP0010771_integument_phenotype1.88734631
33MP0000631_abnormal_neuroendocrine_gland1.85614038
34MP0003111_abnormal_nucleus_morphology1.85563607
35MP0003699_abnormal_female_reproductive1.83544720
36MP0003787_abnormal_imprinting1.83432481
37MP0003698_abnormal_male_reproductive1.81711591
38MP0003121_genomic_imprinting1.75855543
39MP0001968_abnormal_touch/_nociception1.75798464
40MP0001119_abnormal_female_reproductive1.75740232
41MP0008875_abnormal_xenobiotic_pharmacok1.75462351
42MP0001346_abnormal_lacrimal_gland1.74387178
43MP0004043_abnormal_pH_regulation1.71693371
44MP0003646_muscle_fatigue1.65654535
45MP0001216_abnormal_epidermal_layer1.65599723
46MP0005253_abnormal_eye_physiology1.65513314
47MP0005646_abnormal_pituitary_gland1.63368148
48MP0003937_abnormal_limbs/digits/tail_de1.62444107
49MP0009046_muscle_twitch1.59708375
50MP0002736_abnormal_nociception_after1.58745600
51MP0000681_abnormal_thyroid_gland1.58709175
52MP0001145_abnormal_male_reproductive1.58614151
53MP0004381_abnormal_hair_follicle1.58453100
54MP0010386_abnormal_urinary_bladder1.56128233
55MP0002161_abnormal_fertility/fecundity1.54934757
56MP0003077_abnormal_cell_cycle1.52570584
57MP0000383_abnormal_hair_follicle1.51813598
58MP0008872_abnormal_physiological_respon1.48093567
59MP0001501_abnormal_sleep_pattern1.46722090
60MP0000372_irregular_coat_pigmentation1.45154632
61MP0008057_abnormal_DNA_replication1.44348744
62MP0002009_preneoplasia1.43905732
63MP0001529_abnormal_vocalization1.43274967
64MP0004957_abnormal_blastocyst_morpholog1.41080236
65MP0008789_abnormal_olfactory_epithelium1.40261878
66MP0009379_abnormal_foot_pigmentation1.36142688
67MP0000015_abnormal_ear_pigmentation1.36132192
68MP0001984_abnormal_olfaction1.33596434
69MP0002098_abnormal_vibrissa_morphology1.33276069
70MP0010678_abnormal_skin_adnexa1.30295595
71MP0009745_abnormal_behavioral_response1.29852397
72MP0003941_abnormal_skin_development1.29071111
73MP0005645_abnormal_hypothalamus_physiol1.28907273
74MP0003705_abnormal_hypodermis_morpholog1.28122890
75MP0003890_abnormal_embryonic-extraembry1.26904542
76MP0004782_abnormal_surfactant_physiolog1.24313082
77MP0003880_abnormal_central_pattern1.21916674
78MP0002938_white_spotting1.20117044
79MP0003950_abnormal_plasma_membrane1.18313546
80MP0003942_abnormal_urinary_system1.17441060
81MP0004142_abnormal_muscle_tone1.17231138
82MP0000566_synostosis1.17177653
83MP0000427_abnormal_hair_cycle1.16566427
84MP0001188_hyperpigmentation1.16504913
85MP0005075_abnormal_melanosome_morpholog1.16255216
86MP0005666_abnormal_adipose_tissue1.15650269
87MP0001502_abnormal_circadian_rhythm1.14740115
88MP0002751_abnormal_autonomic_nervous1.14241602
89MP0008932_abnormal_embryonic_tissue1.12580825
90MP0001905_abnormal_dopamine_level1.11173200
91MP0002160_abnormal_reproductive_system1.10535728
92MP0003136_yellow_coat_color1.09785104
93MP0010030_abnormal_orbit_morphology1.09447196
94MP0005408_hypopigmentation1.08448243
95MP0002272_abnormal_nervous_system1.07668647
96MP0005380_embryogenesis_phenotype1.05762200
97MP0001672_abnormal_embryogenesis/_devel1.05762200
98MP0000613_abnormal_salivary_gland1.04828978
99MP0004924_abnormal_behavior1.04405666
100MP0005386_behavior/neurological_phenoty1.04405666
101MP0000377_abnormal_hair_follicle1.03908798
102MP0005389_reproductive_system_phenotype1.01485901
103MP0002084_abnormal_developmental_patter1.00875693
104MP0002837_dystrophic_cardiac_calcinosis1.00435888
105MP0001730_embryonic_growth_arrest1.00219746
106MP0003091_abnormal_cell_migration0.99386412
107MP0010307_abnormal_tumor_latency0.98917043
108MP0000350_abnormal_cell_proliferation0.98497609
109MP0009780_abnormal_chondrocyte_physiolo0.97213117
110MP0005395_other_phenotype0.96333399
111MP0001485_abnormal_pinna_reflex0.96179818
112MP0000534_abnormal_ureter_morphology0.95863530
113MP0001191_abnormal_skin_condition0.95455151
114MP0004215_abnormal_myocardial_fiber0.94998086
115MP0003453_abnormal_keratinocyte_physiol0.94469210
116MP0001299_abnormal_eye_distance/0.93850815
117MP0002177_abnormal_outer_ear0.91699202
118MP0003567_abnormal_fetal_cardiomyocyte0.91170503
119MP0004147_increased_porphyrin_level0.90897186
120MP0003938_abnormal_ear_development0.88236536
121MP0000467_abnormal_esophagus_morphology0.88046088
122MP0003984_embryonic_growth_retardation0.86191708
123MP0001697_abnormal_embryo_size0.84658395
124MP0002088_abnormal_embryonic_growth/wei0.82679195
125MP0002653_abnormal_ependyma_morphology0.81324108
126MP0002085_abnormal_embryonic_tissue0.81237508
127MP0002127_abnormal_cardiovascular_syste0.81004773
128MP0002254_reproductive_system_inflammat0.80325279
129MP0001727_abnormal_embryo_implantation0.80214929
130MP0006292_abnormal_olfactory_placode0.79733041
131MP0000367_abnormal_coat/_hair0.79698775
132MP0001661_extended_life_span0.78012833
133MP0006072_abnormal_retinal_apoptosis0.77952852
134MP0002796_impaired_skin_barrier0.77909976
135MP0000639_abnormal_adrenal_gland0.76104940
136MP0009703_decreased_birth_body0.74939694
137MP0002060_abnormal_skin_morphology0.74562844
138MP0004742_abnormal_vestibular_system0.73296889
139MP0001324_abnormal_eye_pigmentation0.72679030
140MP0002064_seizures0.72549293
141MP0005310_abnormal_salivary_gland0.70634673
142MP0001986_abnormal_taste_sensitivity0.69575978
143MP0002572_abnormal_emotion/affect_behav0.69221988
144MP0001486_abnormal_startle_reflex0.68974188
145MP0009931_abnormal_skin_appearance0.68780119
146MP0004510_myositis0.68442666
147MP0002733_abnormal_thermal_nociception0.68333478
148MP0008260_abnormal_autophagy0.66227737
149MP0005647_abnormal_sex_gland0.65878591
150MP0001970_abnormal_pain_threshold0.65688279
151MP0005332_abnormal_amino_acid0.64166875
152MP0003755_abnormal_palate_morphology0.64150588
153MP0010234_abnormal_vibrissa_follicle0.63579760
154MP0002557_abnormal_social/conspecific_i0.63148787
155MP0004270_analgesia0.63104615
156MP0002229_neurodegeneration0.62805170
157MP0003935_abnormal_craniofacial_develop0.62295672
158MP0000230_abnormal_systemic_arterial0.62039451
159MP0000026_abnormal_inner_ear0.61019573
160MP0002234_abnormal_pharynx_morphology0.60787304
161MP0005195_abnormal_posterior_eye0.60720666
162MP0004264_abnormal_extraembryonic_tissu0.59655697
163MP0001764_abnormal_homeostasis0.57896042
164MP0006276_abnormal_autonomic_nervous0.57826291

Predicted human phenotypes

RankGene SetZ-score
1Lip pit (HP:0100267)5.84805603
2Erythroderma (HP:0001019)5.81457087
3Impulsivity (HP:0100710)5.79560924
4Male infertility (HP:0003251)5.69881190
5Palmoplantar hyperkeratosis (HP:0000972)5.27010468
6Palmar hyperkeratosis (HP:0010765)5.08836107
7Congenital nonbullous ichthyosiform erythroderma (HP:0007479)5.00361027
8Congenital ichthyosiform erythroderma (HP:0007431)4.68003852
9Parakeratosis (HP:0001036)4.40639644
10Abnormality of secondary sexual hair (HP:0009888)4.27394325
11Abnormality of the axillary hair (HP:0100134)4.27394325
12Neonatal hypoglycemia (HP:0001998)4.17457604
13Furrowed tongue (HP:0000221)4.16107051
14Conjunctival hamartoma (HP:0100780)4.15167516
15Plantar hyperkeratosis (HP:0007556)4.02310217
16Hypothermia (HP:0002045)4.00431620
17Chromsome breakage (HP:0040012)3.91799707
18Chromosomal breakage induced by crosslinking agents (HP:0003221)3.90070745
19Increased IgE level (HP:0003212)3.75586622
20Pancreatic cysts (HP:0001737)3.69999439
21Corneal erosion (HP:0200020)3.60195073
22Alopecia of scalp (HP:0002293)3.59973731
23Infertility (HP:0000789)3.58259809
24Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.52958491
25Volvulus (HP:0002580)3.50041063
26Congenital stationary night blindness (HP:0007642)3.47652870
27Hypogonadotrophic hypogonadism (HP:0000044)3.44899975
28Onycholysis (HP:0001806)3.39356485
29True hermaphroditism (HP:0010459)3.37710126
30Primary amenorrhea (HP:0000786)3.37322833
31Hypotrichosis (HP:0001006)3.34983946
32Hamartoma of the eye (HP:0010568)3.33678865
33Abnormality of midbrain morphology (HP:0002418)3.30226107
34Molar tooth sign on MRI (HP:0002419)3.30226107
35Premature ovarian failure (HP:0008209)3.27905881
36Pancreatic fibrosis (HP:0100732)3.27569305
37Erythema (HP:0010783)3.26458839
38Facial hemangioma (HP:0000329)3.14132097
39Conjunctival telangiectasia (HP:0000524)3.05690952
40Ectopic kidney (HP:0000086)3.04062223
41Abnormality of the renal collecting system (HP:0004742)3.02078727
42Oral leukoplakia (HP:0002745)3.00857150
43Ectropion (HP:0000656)3.00745440
44Heterotopia (HP:0002282)2.98076096
45Orthostatic hypotension (HP:0001278)2.95542587
46Hypohidrosis (HP:0000966)2.92080661
47Papillary thyroid carcinoma (HP:0002895)2.91058315
48Thick nail (HP:0001805)2.84055771
49Abnormality of the renal cortex (HP:0011035)2.83153628
50Sensory axonal neuropathy (HP:0003390)2.82928870
51Abnormality of chromosome stability (HP:0003220)2.82138298
52Abnormal spermatogenesis (HP:0008669)2.81112086
53Gangrene (HP:0100758)2.77221805
54Hyperventilation (HP:0002883)2.73058531
55Hyperthyroidism (HP:0000836)2.64938342
56Secondary amenorrhea (HP:0000869)2.63655025
57Nephronophthisis (HP:0000090)2.62058673
58Attenuation of retinal blood vessels (HP:0007843)2.56745869
59Abnormality of the renal medulla (HP:0100957)2.52695358
60Abnormal rod and cone electroretinograms (HP:0008323)2.49590373
61Hypochromic microcytic anemia (HP:0004840)2.49109651
62Abnormality of chromosome segregation (HP:0002916)2.42560198
63Abnormality of the preputium (HP:0100587)2.42263906
64Shawl scrotum (HP:0000049)2.41905709
65Palmoplantar keratoderma (HP:0000982)2.40531912
66Truncal obesity (HP:0001956)2.39488975
67Absent/shortened dynein arms (HP:0200106)2.39190531
68Dynein arm defect of respiratory motile cilia (HP:0012255)2.39190531
69Increased nuchal translucency (HP:0010880)2.37876295
70Myokymia (HP:0002411)2.37859126
71Fair hair (HP:0002286)2.35483689
72Congenital, generalized hypertrichosis (HP:0004540)2.35009328
73Cortical dysplasia (HP:0002539)2.33631364
74Abnormal autonomic nervous system physiology (HP:0012332)2.32791215
75Abnormality of the vasculature of the conjunctiva (HP:0008054)2.32721406
76Pustule (HP:0200039)2.32698009
77Absent hair (HP:0002298)2.32292581
78Abnormality of nail color (HP:0100643)2.31485489
79Oligodactyly (hands) (HP:0001180)2.30322405
80Hypoplastic labia majora (HP:0000059)2.29362571
81Tubular atrophy (HP:0000092)2.28613009
82Adrenal hypoplasia (HP:0000835)2.28608155
83Medial flaring of the eyebrow (HP:0010747)2.27677934
84Aplasia/Hypoplasia of the uvula (HP:0010293)2.27399595
85Woolly hair (HP:0002224)2.24627331
86Decreased testicular size (HP:0008734)2.24261484
87Exotropia (HP:0000577)2.24211865
88Duodenal stenosis (HP:0100867)2.23038742
89Small intestinal stenosis (HP:0012848)2.23038742
90Abnormality of cochlea (HP:0000375)2.22352156
91Preauricular pit (HP:0004467)2.21822483
92Periauricular skin pits (HP:0100277)2.21822483
93Gaze-evoked nystagmus (HP:0000640)2.21515895
94Abnormality of the carotid arteries (HP:0005344)2.20803491
95Type II lissencephaly (HP:0007260)2.20611826
96Azoospermia (HP:0000027)2.20573396
97Sparse eyelashes (HP:0000653)2.20520824
98Cystic liver disease (HP:0006706)2.20072772
99Absent rod-and cone-mediated responses on ERG (HP:0007688)2.19380374
100Pruritus (HP:0000989)2.16999959
101Microglossia (HP:0000171)2.16119171
102Subcapsular cataract (HP:0000523)2.15321489
103Breast hypoplasia (HP:0003187)2.14497181
104Chronic hepatic failure (HP:0100626)2.14354470
105Decreased central vision (HP:0007663)2.13742409
106Breast aplasia (HP:0100783)2.13525604
107Delayed puberty (HP:0000823)2.13396114
108Cupped ear (HP:0000378)2.13152262
109Aplasia/Hypoplasia of the breasts (HP:0010311)2.12755733
110Skin pits (HP:0100276)2.12405645
111Large for gestational age (HP:0001520)2.11142197
112Thyroid carcinoma (HP:0002890)2.08028677
113Agitation (HP:0000713)2.07649737
114Overlapping toe (HP:0001845)2.04932864
115Abnormality of the labia majora (HP:0012881)2.03704248
116Increased number of teeth (HP:0011069)2.02259586
117Abnormal respiratory motile cilium physiology (HP:0012261)2.02207339
118Absent eyelashes (HP:0000561)2.00882241
119Abnormal biliary tract physiology (HP:0012439)1.99212429
120Bile duct proliferation (HP:0001408)1.99212429
121Autoamputation (HP:0001218)1.98943719
122Abolished electroretinogram (ERG) (HP:0000550)1.98502867
123Macroorchidism (HP:0000053)1.97209698
124Follicular hyperkeratosis (HP:0007502)1.96107539
125Aplasia/Hypoplasia of the tongue (HP:0010295)1.93852116
126Keratoconus (HP:0000563)1.93383637
127Increased corneal curvature (HP:0100692)1.93383637
128Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.91871622
129Abnormality of alanine metabolism (HP:0010916)1.91871622
130Hyperalaninemia (HP:0003348)1.91871622
131Generalized hypopigmentation of hair (HP:0011358)1.90830606
132Widely spaced teeth (HP:0000687)1.89003657
133Meckel diverticulum (HP:0002245)1.88430329
134Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.87230868
135Papilledema (HP:0001085)1.85627078
136Pendular nystagmus (HP:0012043)1.85171016
137Renal cortical cysts (HP:0000803)1.83097081
138Progressive inability to walk (HP:0002505)1.82727970
139Abnormal drinking behavior (HP:0030082)1.82278208
140Polydipsia (HP:0001959)1.82278208
141Inability to walk (HP:0002540)1.80550801
142Absent radius (HP:0003974)1.79928162
143Cafe-au-lait spot (HP:0000957)1.79592102
144Abnormality of the proximal phalanges of the hand (HP:0009834)1.79306350
145Chronic bronchitis (HP:0004469)1.78752875
146Oligodactyly (HP:0012165)1.77654401
147Abnormality of the diencephalon (HP:0010662)1.77013271
148Abnormality of lateral ventricle (HP:0030047)1.76688873
149Myelodysplasia (HP:0002863)1.75930994
150Arterial tortuosity (HP:0005116)1.75405122
151Gait imbalance (HP:0002141)1.74884081
152Nephroblastoma (Wilms tumor) (HP:0002667)1.74635218
153Sclerocornea (HP:0000647)1.73934780
154Congenital primary aphakia (HP:0007707)1.73835200
155Duplicated collecting system (HP:0000081)1.73702588
156Conical tooth (HP:0000698)1.72645973
157Nephrogenic diabetes insipidus (HP:0009806)1.72360459
158Chorioretinal atrophy (HP:0000533)1.71319785
159Abnormality of placental membranes (HP:0011409)1.71186390
160Amniotic constriction ring (HP:0009775)1.71186390
161Abnormality of the ileum (HP:0001549)1.70501040
162External ophthalmoplegia (HP:0000544)1.70431486
163Clubbing of toes (HP:0100760)1.69910622
164Abnormality of the duodenum (HP:0002246)1.69074663
165Bony spicule pigmentary retinopathy (HP:0007737)1.68766897
166Absent forearm bone (HP:0003953)1.68687302
167Aplasia involving forearm bones (HP:0009822)1.68687302
168Embryonal renal neoplasm (HP:0011794)1.68510622
169Brittle hair (HP:0002299)1.67580153
170Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.67170754
171Anencephaly (HP:0002323)1.66972389
172Congenital hepatic fibrosis (HP:0002612)1.66741638
173Hypoplastic pelvis (HP:0008839)1.66652381
174Lissencephaly (HP:0001339)1.66123191
175Disinhibition (HP:0000734)1.65810306
176Slow-growing hair (HP:0002217)1.65488480
177Abnormality of hair growth rate (HP:0011363)1.65488480
178Decreased electroretinogram (ERG) amplitude (HP:0000654)1.65161994
179Birth length less than 3rd percentile (HP:0003561)1.65083188
180Pili torti (HP:0003777)1.64592411
181Insidious onset (HP:0003587)1.64441703
182Termporal pattern (HP:0011008)1.64441703
183Decreased circulating renin level (HP:0003351)1.63354036
184X-linked recessive inheritance (HP:0001419)1.62779100
185Flat capital femoral epiphysis (HP:0003370)1.62275388
186Intellectual disability, mild (HP:0001256)1.62136393
187Hyporeflexia of lower limbs (HP:0002600)1.62120412
188Abnormality of macular pigmentation (HP:0008002)1.61351163
189Thyroid-stimulating hormone excess (HP:0002925)1.60686641
190Amblyopia (HP:0000646)1.60548976
191Polyuria (HP:0000103)1.59314864
192Stomatitis (HP:0010280)1.59007593

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK6.78836675
2PLK43.63476023
3KSR23.48016431
4MELK3.47308943
5LATS23.19917481
6ADRBK23.18113686
7NUAK12.91659580
8LATS12.87432669
9MAP3K62.76475680
10CDC72.75565062
11MAP4K22.72395519
12MAP3K92.58195673
13BMPR1B2.38176497
14TRPM72.29850540
15BMPR22.28418289
16TTK2.24173992
17NEK22.19290912
18ZAK2.12992009
19GRK12.05277827
20TGFBR12.00668769
21MOS1.98104780
22TXK1.83902085
23ACVR1B1.82463998
24TRIB31.81401179
25NTRK11.77653356
26CDK91.76038631
27MAP3K21.75989853
28PINK11.75729167
29TAOK31.74164972
30CAMKK21.73888839
31CASK1.71332451
32ERBB41.70056521
33STK31.68672482
34MAPK131.63124269
35MST41.54736103
36GRK51.53105294
37BRSK11.52128345
38RET1.51349027
39FER1.44384073
40MKNK21.42480644
41AURKB1.41493349
42INSRR1.39127428
43NEK91.38337797
44IRAK11.36180775
45OXSR11.35988476
46PDK31.35665134
47PDK41.35665134
48KSR11.33581755
49PRKCE1.33123038
50PAK61.33054922
51TLK11.29617099
52BRAF1.28824048
53PLK11.28637584
54BUB11.28235926
55MAP2K61.28089349
56EPHA31.27867554
57RAF11.27327844
58BRSK21.27064932
59STK101.26694046
60TRIM281.23144131
61DYRK21.18172652
62CDK81.11733241
63MAP3K41.11408675
64DYRK1B1.10215387
65MAP2K11.09354032
66CDK121.08941116
67MUSK1.08846463
68CHEK21.08087911
69EIF2AK31.07883562
70CDK61.06683207
71PKN21.05674053
72YES11.05021709
73CSNK1G21.04370087
74NLK1.00538022
75BCR1.00321952
76STK38L0.99974319
77TAF10.97522642
78CSNK1G30.96213513
79DAPK20.95694449
80IKBKB0.93766752
81PLK20.92783149
82FGFR20.92746139
83CDK40.91964496
84TNIK0.91091133
85PNCK0.85465954
86CSNK1G10.85157441
87EEF2K0.84444719
88VRK10.83700618
89PLK30.82988119
90BRD40.82718055
91PRKCG0.82651938
92DYRK30.79666214
93PTK2B0.79428169
94MAP3K130.76880838
95NEK10.76379689
96PRKD30.74091038
97MAP2K40.73902773
98MAP3K80.73506835
99MARK10.72945952
100NTRK30.70858722
101CHEK10.70437745
102MAPKAPK50.69679455
103ATM0.66292302
104CSNK1A1L0.66234642
105TIE10.65993688
106STK380.63749545
107SCYL20.63425070
108NTRK20.62876394
109TAOK10.62802475
110PKN10.61209263
111STK110.59782938
112AKT30.59596713
113TYRO30.59477946
114PAK30.58541221
115MKNK10.57236519
116FGFR10.54357632
117ARAF0.54156589
118EIF2AK10.51357719
119MAPKAPK30.50764378
120ADRBK10.50558336
121HIPK20.49910455
122PRKCI0.49433128
123FGR0.49110849
124CDK10.48663925
125UHMK10.48402758
126KIT0.48178884
127RIPK40.48072441
128PIK3CG0.47779441
129PRKCQ0.47589536
130GRK70.47274197
131CDC42BPA0.47249695
132PIK3CA0.46265431
133CAMK2A0.45833910
134ITK0.45656617
135MATK0.45271736
136PHKG10.43953265
137PHKG20.43953265
138CDK30.43900280
139WEE10.43621126
140WNK40.43178776
141AURKA0.43085094
142TEC0.42958305
143CDK20.42650118
144ERBB30.42069451
145EPHA40.40913253
146MAP3K10.39877671
147WNK30.39393186
148MAP2K70.36972423
149WNK10.36761743
150PRKAA20.35604689
151STK390.35337111
152CHUK0.35223872
153PRKACA0.34975853
154STK240.34898226
155RPS6KA50.34848989
156PRKAA10.34479105
157RIPK10.33894424
158FGFR30.33291239
159VRK20.33080792
160BCKDK0.32967180
161MINK10.32683009
162CSNK1D0.30286099
163CAMK10.30036055
164CAMK1G0.29775145
165MAP3K120.29769996
166MAP3K50.29696599
167IGF1R0.28487171
168DYRK1A0.28226686

Predicted pathways (KEGG)

RankGene SetZ-score
1* Ovarian steroidogenesis_Homo sapiens_hsa049134.00839761
2Regulation of lipolysis in adipocytes_Homo sapiens_hsa049233.17615054
3* GnRH signaling pathway_Homo sapiens_hsa049123.07974570
4Autoimmune thyroid disease_Homo sapiens_hsa053202.97689944
5Cell cycle_Homo sapiens_hsa041102.92366085
6Dorso-ventral axis formation_Homo sapiens_hsa043202.81299418
7Caffeine metabolism_Homo sapiens_hsa002322.53572929
8Nitrogen metabolism_Homo sapiens_hsa009102.45504863
9Prolactin signaling pathway_Homo sapiens_hsa049172.43880316
10Vitamin B6 metabolism_Homo sapiens_hsa007502.40147481
11Oocyte meiosis_Homo sapiens_hsa041142.30078021
12Progesterone-mediated oocyte maturation_Homo sapiens_hsa049142.20413748
13Basal transcription factors_Homo sapiens_hsa030222.09429054
14* Arachidonic acid metabolism_Homo sapiens_hsa005902.07962129
15Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.04563826
16Phototransduction_Homo sapiens_hsa047442.01983869
17Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.99159354
18Butanoate metabolism_Homo sapiens_hsa006501.89703630
19Type II diabetes mellitus_Homo sapiens_hsa049301.75890862
20Protein export_Homo sapiens_hsa030601.75628878
21Tryptophan metabolism_Homo sapiens_hsa003801.71699656
22Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.69726438
23Circadian rhythm_Homo sapiens_hsa047101.59501309
24Selenocompound metabolism_Homo sapiens_hsa004501.58147345
25Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.57978476
26Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.57003244
27Nicotine addiction_Homo sapiens_hsa050331.55206747
28Maturity onset diabetes of the young_Homo sapiens_hsa049501.53672681
29Fanconi anemia pathway_Homo sapiens_hsa034601.50232362
30Histidine metabolism_Homo sapiens_hsa003401.48976220
31Propanoate metabolism_Homo sapiens_hsa006401.48685245
32Pancreatic cancer_Homo sapiens_hsa052121.48656310
33Longevity regulating pathway - mammal_Homo sapiens_hsa042111.45210710
34ABC transporters_Homo sapiens_hsa020101.41894149
35Regulation of autophagy_Homo sapiens_hsa041401.41824837
36Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.40380118
37Olfactory transduction_Homo sapiens_hsa047401.35369019
38Oxidative phosphorylation_Homo sapiens_hsa001901.32395150
39TGF-beta signaling pathway_Homo sapiens_hsa043501.31629029
40FoxO signaling pathway_Homo sapiens_hsa040681.30858071
41Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.29706614
42Colorectal cancer_Homo sapiens_hsa052101.28464647
43Sphingolipid metabolism_Homo sapiens_hsa006001.28162144
44Steroid hormone biosynthesis_Homo sapiens_hsa001401.27471980
45p53 signaling pathway_Homo sapiens_hsa041151.25509139
46RNA polymerase_Homo sapiens_hsa030201.24683452
47Primary bile acid biosynthesis_Homo sapiens_hsa001201.22745185
48Thyroid hormone synthesis_Homo sapiens_hsa049181.21387387
49Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.20300375
50Taste transduction_Homo sapiens_hsa047421.19612073
51Phenylalanine metabolism_Homo sapiens_hsa003601.19496982
52Chemical carcinogenesis_Homo sapiens_hsa052041.16739263
53Adipocytokine signaling pathway_Homo sapiens_hsa049201.16069013
54Estrogen signaling pathway_Homo sapiens_hsa049151.16057047
55Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.14789481
56Retinol metabolism_Homo sapiens_hsa008301.12069327
57Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.11843867
58Inositol phosphate metabolism_Homo sapiens_hsa005621.10334440
59Tyrosine metabolism_Homo sapiens_hsa003501.10086513
60RNA degradation_Homo sapiens_hsa030181.09540919
61* Ether lipid metabolism_Homo sapiens_hsa005651.08596056
62Cocaine addiction_Homo sapiens_hsa050301.03653474
63MicroRNAs in cancer_Homo sapiens_hsa052061.02855563
64Cholinergic synapse_Homo sapiens_hsa047251.02741891
65* Serotonergic synapse_Homo sapiens_hsa047261.02401577
66beta-Alanine metabolism_Homo sapiens_hsa004101.01809932
67Morphine addiction_Homo sapiens_hsa050320.99864424
68Fat digestion and absorption_Homo sapiens_hsa049750.98936359
69Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.96263308
70* alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.92872400
71Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.92562731
72Salivary secretion_Homo sapiens_hsa049700.92478472
73* Glutamatergic synapse_Homo sapiens_hsa047240.91182671
74Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.90931522
75Thyroid hormone signaling pathway_Homo sapiens_hsa049190.90795014
76Dopaminergic synapse_Homo sapiens_hsa047280.90284780
77AMPK signaling pathway_Homo sapiens_hsa041520.89510361
78Phosphatidylinositol signaling system_Homo sapiens_hsa040700.87992413
79Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.87288847
80* VEGF signaling pathway_Homo sapiens_hsa043700.86613426
81Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.86462162
82* Linoleic acid metabolism_Homo sapiens_hsa005910.86316268
83Insulin signaling pathway_Homo sapiens_hsa049100.85713583
84Amphetamine addiction_Homo sapiens_hsa050310.85129927
85Intestinal immune network for IgA production_Homo sapiens_hsa046720.84890223
86* Vascular smooth muscle contraction_Homo sapiens_hsa042700.83938228
87Fatty acid biosynthesis_Homo sapiens_hsa000610.82767078
88One carbon pool by folate_Homo sapiens_hsa006700.80811725
89Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.78691132
90Pyruvate metabolism_Homo sapiens_hsa006200.78275523
91* Choline metabolism in cancer_Homo sapiens_hsa052310.78191273
92Hippo signaling pathway_Homo sapiens_hsa043900.78170023
93Collecting duct acid secretion_Homo sapiens_hsa049660.76638911
94Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.75904260
95* Glycerophospholipid metabolism_Homo sapiens_hsa005640.74950105
96RNA transport_Homo sapiens_hsa030130.74621027
97Renal cell carcinoma_Homo sapiens_hsa052110.74045539
98mRNA surveillance pathway_Homo sapiens_hsa030150.73172395
99cGMP-PKG signaling pathway_Homo sapiens_hsa040220.73153266
100Chronic myeloid leukemia_Homo sapiens_hsa052200.71764867
101Peroxisome_Homo sapiens_hsa041460.71315360
102Small cell lung cancer_Homo sapiens_hsa052220.70957664
103Homologous recombination_Homo sapiens_hsa034400.70667332
104Calcium signaling pathway_Homo sapiens_hsa040200.69283637
105Insulin secretion_Homo sapiens_hsa049110.69258503
106Fatty acid elongation_Homo sapiens_hsa000620.68693210
107Adherens junction_Homo sapiens_hsa045200.68161132
108Parkinsons disease_Homo sapiens_hsa050120.67959954
109Steroid biosynthesis_Homo sapiens_hsa001000.67745420
110* Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.67591902
111* Long-term depression_Homo sapiens_hsa047300.65577795
112mTOR signaling pathway_Homo sapiens_hsa041500.64939475
113Cyanoamino acid metabolism_Homo sapiens_hsa004600.63419488
114Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.63077677
115Sulfur metabolism_Homo sapiens_hsa009200.61182209
116GABAergic synapse_Homo sapiens_hsa047270.60619173
117Glucagon signaling pathway_Homo sapiens_hsa049220.58848465
118Glioma_Homo sapiens_hsa052140.57589680
119Non-small cell lung cancer_Homo sapiens_hsa052230.56284845
120Glycerolipid metabolism_Homo sapiens_hsa005610.56179416
121Endometrial cancer_Homo sapiens_hsa052130.55928834
122AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.54942856
123ErbB signaling pathway_Homo sapiens_hsa040120.53617433
124Nucleotide excision repair_Homo sapiens_hsa034200.53607783
125Prostate cancer_Homo sapiens_hsa052150.53596095
126Purine metabolism_Homo sapiens_hsa002300.53115712
127Circadian entrainment_Homo sapiens_hsa047130.53097972
128Fatty acid degradation_Homo sapiens_hsa000710.53046230
129Pancreatic secretion_Homo sapiens_hsa049720.52602561
130Base excision repair_Homo sapiens_hsa034100.52169648
131* Ras signaling pathway_Homo sapiens_hsa040140.51459697
132Gap junction_Homo sapiens_hsa045400.51299488
133* Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.51185426
134Wnt signaling pathway_Homo sapiens_hsa043100.50932635
135* Metabolic pathways_Homo sapiens_hsa011000.50392472
136Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.50062975
137Thyroid cancer_Homo sapiens_hsa052160.50035025
138Sphingolipid signaling pathway_Homo sapiens_hsa040710.49872567
139Pentose and glucuronate interconversions_Homo sapiens_hsa000400.49689364
140Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.48886778
141Hepatitis B_Homo sapiens_hsa051610.48775134
142DNA replication_Homo sapiens_hsa030300.48518293
143Arginine and proline metabolism_Homo sapiens_hsa003300.47425585
144Fatty acid metabolism_Homo sapiens_hsa012120.47404341
145Alzheimers disease_Homo sapiens_hsa050100.47105746
146Huntingtons disease_Homo sapiens_hsa050160.45602363
147Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.45545618
148Mineral absorption_Homo sapiens_hsa049780.45082086
149Proteasome_Homo sapiens_hsa030500.44995845
150Asthma_Homo sapiens_hsa053100.44340310
151Aldosterone synthesis and secretion_Homo sapiens_hsa049250.44150107
152SNARE interactions in vesicular transport_Homo sapiens_hsa041300.41850971
153Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.41691175
154Epstein-Barr virus infection_Homo sapiens_hsa051690.40801510
155Gastric acid secretion_Homo sapiens_hsa049710.40750726
156Renin secretion_Homo sapiens_hsa049240.40599318
157Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.38881221
158Type I diabetes mellitus_Homo sapiens_hsa049400.38227438
159Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.38006680
160Primary immunodeficiency_Homo sapiens_hsa053400.37764340
161Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.37019542
162Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.36607340
163Melanogenesis_Homo sapiens_hsa049160.36343453
164Long-term potentiation_Homo sapiens_hsa047200.36060048
165cAMP signaling pathway_Homo sapiens_hsa040240.35678381
166Cardiac muscle contraction_Homo sapiens_hsa042600.34889897
167Hedgehog signaling pathway_Homo sapiens_hsa043400.33825469
168* Phospholipase D signaling pathway_Homo sapiens_hsa040720.33613609
169* Oxytocin signaling pathway_Homo sapiens_hsa049210.32744032
170* MAPK signaling pathway_Homo sapiens_hsa040100.32490486
171Mismatch repair_Homo sapiens_hsa034300.32283277
172Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.29732164
173Non-homologous end-joining_Homo sapiens_hsa034500.28588862
174Cysteine and methionine metabolism_Homo sapiens_hsa002700.28462934

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