PLA2G4E

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the cytosolic phospholipase A2 group IV family. Members of this family are involved in regulation of membrane tubule-mediated transport. The enzyme encoded by this member of the family plays a role in trafficking through the clathrin-independent endocytic pathway. The enzyme regulates the recycling process via formation of tubules that transport internalized clathrin-independent cargo proteins back to the cell surface. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1keratinocyte differentiation (GO:0030216)9.88969243
2molting cycle (GO:0042303)8.86007342
3hair cycle (GO:0042633)8.86007342
4desmosome organization (GO:0002934)8.74908194
5polyketide metabolic process (GO:0030638)8.58148667
6doxorubicin metabolic process (GO:0044598)8.58148667
7daunorubicin metabolic process (GO:0044597)8.58148667
8multicellular organismal water homeostasis (GO:0050891)7.51466804
9epidermal cell differentiation (GO:0009913)7.47186185
10keratinocyte proliferation (GO:0043616)7.02839766
11peptide cross-linking (GO:0018149)6.79121557
12* phosphatidylinositol acyl-chain remodeling (GO:0036149)6.57166465
13water homeostasis (GO:0030104)6.52071862
14epidermis development (GO:0008544)6.50101852
15* phosphatidylserine acyl-chain remodeling (GO:0036150)6.28922825
16phosphatidylglycerol acyl-chain remodeling (GO:0036148)5.96754736
17maintenance of protein location in nucleus (GO:0051457)5.93127127
18intermediate filament organization (GO:0045109)5.60686447
19bundle of His cell to Purkinje myocyte communication (GO:0086069)5.38058392
20aminoglycoside antibiotic metabolic process (GO:0030647)5.37236269
21regulation of response to osmotic stress (GO:0047484)5.25431376
22* phosphatidylethanolamine acyl-chain remodeling (GO:0036152)5.25335303
23regulation of natural killer cell differentiation (GO:0032823)5.19271587
24somite rostral/caudal axis specification (GO:0032525)5.16677725
25lipoxygenase pathway (GO:0019372)4.92758807
26negative regulation of epidermis development (GO:0045683)4.78814290
27intermediate filament cytoskeleton organization (GO:0045104)4.76298244
28regulation of MHC class I biosynthetic process (GO:0045343)4.67521228
29intermediate filament-based process (GO:0045103)4.66908917
30detection of bacterium (GO:0016045)4.66342612
31linoleic acid metabolic process (GO:0043651)4.65008074
32negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)4.62145615
33* phosphatidylcholine acyl-chain remodeling (GO:0036151)4.59999017
34regulation of mammary gland epithelial cell proliferation (GO:0033599)4.50704439
35negative regulation of potassium ion transmembrane transporter activity (GO:1901017)4.48090255
36response to dietary excess (GO:0002021)4.41761252
37phenol-containing compound catabolic process (GO:0019336)4.40307361
38keratinocyte development (GO:0003334)4.38164122
39cytidine deamination (GO:0009972)4.37540329
40cytidine metabolic process (GO:0046087)4.37540329
41cytidine catabolic process (GO:0006216)4.37540329
42regulation of nuclear cell cycle DNA replication (GO:0033262)4.26534562
43regulation of cilium movement (GO:0003352)4.23309195
44proline transport (GO:0015824)4.11990812
45detection of other organism (GO:0098543)4.06437761
46muscle organ morphogenesis (GO:0048644)4.00119601
47mitochondrion distribution (GO:0048311)3.96368151
48negative regulation of cell cycle G2/M phase transition (GO:1902750)3.93839474
49histone H4-K12 acetylation (GO:0043983)3.93718553
50calcium-mediated signaling using intracellular calcium source (GO:0035584)3.92585019
51ectoderm development (GO:0007398)3.92102800
52quinone metabolic process (GO:1901661)3.89367510
53histone H4-K8 acetylation (GO:0043982)3.87834891
54histone H4-K5 acetylation (GO:0043981)3.87834891
55response to pheromone (GO:0019236)3.85707802
56microtubule severing (GO:0051013)3.76668999
57negative regulation of epidermal cell differentiation (GO:0045605)3.76190497
58protein polyglutamylation (GO:0018095)3.69827573
59regulation of telomere maintenance via telomerase (GO:0032210)3.66373178
60establishment of planar polarity (GO:0001736)3.64920602
61establishment of tissue polarity (GO:0007164)3.64920602
62rRNA methylation (GO:0031167)3.64082704
63synaptic vesicle maturation (GO:0016188)3.63297889
64gap junction assembly (GO:0016264)3.62417396
65rRNA transcription (GO:0009303)3.60051975
66negative regulation of telomerase activity (GO:0051974)3.56661762
67notochord development (GO:0030903)3.56368826
68neuron cell-cell adhesion (GO:0007158)3.53912755
69negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)3.51127801
70* phosphatidylserine metabolic process (GO:0006658)3.47119199
71negative regulation of potassium ion transmembrane transport (GO:1901380)3.46792603
72behavioral response to nicotine (GO:0035095)3.42943214
73detection of temperature stimulus (GO:0016048)3.37179980
74negative regulation of interferon-gamma production (GO:0032689)3.36826766
75cell fate commitment involved in formation of primary germ layer (GO:0060795)3.36067651
76branching involved in mammary gland duct morphogenesis (GO:0060444)3.33530492
77phosphatidylglycerol metabolic process (GO:0046471)3.32578899
78cerebellar granule cell differentiation (GO:0021707)3.31576980
79negative regulation of telomere maintenance (GO:0032205)3.29112687
80positive regulation of monocyte chemotaxis (GO:0090026)3.28933411
81skin morphogenesis (GO:0043589)3.26974514
82* phospholipid catabolic process (GO:0009395)3.20528065
83pyrimidine ribonucleoside catabolic process (GO:0046133)3.18532390
84ceramide biosynthetic process (GO:0046513)3.16043409
85nucleoside transmembrane transport (GO:1901642)3.14110727
86hemidesmosome assembly (GO:0031581)3.13679405
87rRNA modification (GO:0000154)3.13614033
88positive regulation of T cell chemotaxis (GO:0010820)3.12972648
89regulation of T cell chemotaxis (GO:0010819)3.12972648
90epithelium development (GO:0060429)3.12911251
91neuronal action potential propagation (GO:0019227)3.12797270
92lateral sprouting from an epithelium (GO:0060601)3.11519792
93ventricular system development (GO:0021591)3.03993084
94coenzyme catabolic process (GO:0009109)3.03777060
95regulation of microtubule-based movement (GO:0060632)3.03026221
96one-carbon compound transport (GO:0019755)3.02604499
97positive regulation of digestive system process (GO:0060456)3.00714790
98glutamate secretion (GO:0014047)2.95484620
99bone trabecula formation (GO:0060346)2.94564205
100regulation of odontogenesis of dentin-containing tooth (GO:0042487)2.93718673
101regulation of short-term neuronal synaptic plasticity (GO:0048172)2.93356984
102neurotransmitter uptake (GO:0001504)2.92726447
103presynaptic membrane assembly (GO:0097105)2.91708205
104detection of light stimulus involved in sensory perception (GO:0050962)2.91469612
105detection of light stimulus involved in visual perception (GO:0050908)2.91469612
106histone H4-K16 acetylation (GO:0043984)2.90997629
107positive regulation of DNA-dependent DNA replication (GO:2000105)2.90657962
108cullin deneddylation (GO:0010388)2.87084565
109fatty acid elongation (GO:0030497)2.85480020
110polarized epithelial cell differentiation (GO:0030859)2.84766945
111sequestering of metal ion (GO:0051238)2.82262619
112synaptic vesicle exocytosis (GO:0016079)2.82126293
113mitotic sister chromatid segregation (GO:0000070)2.80686973
114negative regulation of peptidyl-serine phosphorylation (GO:0033137)2.78876405
115vocalization behavior (GO:0071625)2.78177947
116transepithelial transport (GO:0070633)2.77868403
117synaptic transmission, glutamatergic (GO:0035249)2.76645849
118phosphatidylinositol 3-kinase signaling (GO:0014065)2.75413665
119regulation of natural killer cell activation (GO:0032814)2.75098633
120fucose catabolic process (GO:0019317)2.74965238
121L-fucose metabolic process (GO:0042354)2.74965238
122L-fucose catabolic process (GO:0042355)2.74965238
123regulation of keratinocyte proliferation (GO:0010837)2.74388065
124establishment of skin barrier (GO:0061436)2.74382321
125hormone catabolic process (GO:0042447)2.74293589
126magnesium ion transport (GO:0015693)2.74251809
127negative regulation of systemic arterial blood pressure (GO:0003085)2.71432988
128protein localization to synapse (GO:0035418)2.70385322
129arachidonic acid secretion (GO:0050482)2.70226704
130icosanoid secretion (GO:0032309)2.70226704
131presynaptic membrane organization (GO:0097090)2.70158331
132interferon-gamma production (GO:0032609)2.70103566
133platelet dense granule organization (GO:0060155)2.68859184
134tachykinin receptor signaling pathway (GO:0007217)2.68219492
135primitive streak formation (GO:0090009)2.67136534
136regulation of telomere maintenance (GO:0032204)2.66748138
137cardiovascular system development (GO:0072358)2.66044934
138negative regulation of keratinocyte proliferation (GO:0010839)2.65036660
139G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.64099117
140intestinal epithelial cell development (GO:0060576)2.63937379
141* alditol phosphate metabolic process (GO:0052646)2.63216652
142neuron-neuron synaptic transmission (GO:0007270)2.62132153
143sarcoplasmic reticulum calcium ion transport (GO:0070296)2.61956306
144protein K11-linked deubiquitination (GO:0035871)2.61690673
145epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.60842733
146establishment of mitochondrion localization (GO:0051654)2.60548845
147mitochondrion localization (GO:0051646)2.60110651
148defense response to fungus (GO:0050832)2.59108377
149protein localization to kinetochore (GO:0034501)2.58638587
150long-chain fatty acid biosynthetic process (GO:0042759)2.58178866
151cellular ketone body metabolic process (GO:0046950)2.57653451
152behavioral defense response (GO:0002209)2.57341694
153behavioral fear response (GO:0001662)2.57341694
154regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.55939719
155negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.55238650
156regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.55224754
157tryptophan catabolic process (GO:0006569)2.53190785
158indole-containing compound catabolic process (GO:0042436)2.53190785
159indolalkylamine catabolic process (GO:0046218)2.53190785
160maintenance of protein localization in organelle (GO:0072595)2.51356968
161keratinization (GO:0031424)2.51351746
162cornea development in camera-type eye (GO:0061303)2.51241410
163positive regulation of synapse maturation (GO:0090129)2.51183342
164protein localization to cilium (GO:0061512)2.51135731
165phosphatidic acid metabolic process (GO:0046473)2.49913172
166phosphatidic acid biosynthetic process (GO:0006654)2.49913172
167glutamate receptor signaling pathway (GO:0007215)2.49590223
168anterior/posterior axis specification (GO:0009948)2.49402947
169negative regulation of interleukin-17 production (GO:0032700)2.49399833
170regulation of mesoderm development (GO:2000380)2.47631663
171kynurenine metabolic process (GO:0070189)2.47127218
172regulation of heart rate by cardiac conduction (GO:0086091)2.46936635
173kidney morphogenesis (GO:0060993)2.45383243
174photoreceptor cell maintenance (GO:0045494)2.43198673
175serotonin metabolic process (GO:0042428)2.42925224
176parturition (GO:0007567)2.42333547
177primary amino compound metabolic process (GO:1901160)2.39763869
178hair follicle morphogenesis (GO:0031069)2.39748994
179detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.38525653
180indolalkylamine metabolic process (GO:0006586)2.37378065
181positive regulation of glomerulus development (GO:0090193)2.33430684
182ketone body metabolic process (GO:1902224)2.32710025
183sphingolipid biosynthetic process (GO:0030148)2.31961202
184gamma-aminobutyric acid transport (GO:0015812)2.28537356
185thyroid hormone metabolic process (GO:0042403)2.26419410
186* phosphatidylcholine metabolic process (GO:0046470)2.24944503
187piRNA metabolic process (GO:0034587)2.24688802
188tryptophan metabolic process (GO:0006568)2.24258763
189ventricular cardiac muscle cell action potential (GO:0086005)2.23775416
190neuronal action potential (GO:0019228)2.21130988
191indole-containing compound metabolic process (GO:0042430)2.20823965
192multicellular organism reproduction (GO:0032504)2.19166449
193sympathetic nervous system development (GO:0048485)2.19067133
194action potential (GO:0001508)2.18726264
195glycerophospholipid catabolic process (GO:0046475)2.12534444
196regulation of water loss via skin (GO:0033561)11.8323526

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human5.98270645
2KLF5_18264089_ChIP-ChIP_MESCs_Mouse5.66096903
3KLF4_18264089_ChIP-ChIP_MESCs_Mouse5.66096903
4KLF2_18264089_ChIP-ChIP_MESCs_Mouse5.66096903
5BP1_19119308_ChIP-ChIP_Hs578T_Human5.65902343
6ZNF274_21170338_ChIP-Seq_K562_Hela3.09255546
7EZH2_22144423_ChIP-Seq_EOC_Human3.05543507
8NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.81220198
9NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.72440636
10SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.50514816
11TP63_19390658_ChIP-ChIP_HaCaT_Human2.29904332
12SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.29815742
13* P63_26484246_Chip-Seq_KERATINOCYTES_Human2.26695101
14ZFP57_27257070_Chip-Seq_ESCs_Mouse2.24076172
15RNF2_27304074_Chip-Seq_NSC_Mouse2.04176184
16SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.97920175
17RNF2_18974828_ChIP-Seq_MESCs_Mouse1.92451020
18EZH2_18974828_ChIP-Seq_MESCs_Mouse1.92451020
19GBX2_23144817_ChIP-Seq_PC3_Human1.91990416
20RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.91582393
21* TCF3_18692474_ChIP-Seq_MESCs_Mouse1.89718249
22GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.89117132
23IRF1_19129219_ChIP-ChIP_H3396_Human1.89055568
24BMI1_23680149_ChIP-Seq_NPCS_Mouse1.88470199
25EZH2_27304074_Chip-Seq_ESCs_Mouse1.84720626
26NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.84468705
27JARID2_20064375_ChIP-Seq_MESCs_Mouse1.82656640
28ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.81310227
29VDR_22108803_ChIP-Seq_LS180_Human1.79670806
30GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.75824155
31TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.74326952
32SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.72525189
33REST_21632747_ChIP-Seq_MESCs_Mouse1.71372157
34POU3F2_20337985_ChIP-ChIP_501MEL_Human1.71064355
35AR_21572438_ChIP-Seq_LNCaP_Human1.70538061
36SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.69865063
37FOXA1_25329375_ChIP-Seq_VCAP_Human1.68108448
38FOXA1_27270436_Chip-Seq_PROSTATE_Human1.68108448
39* NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.65103112
40CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.63865334
41FUS_26573619_Chip-Seq_HEK293_Human1.60304714
42RNF2_27304074_Chip-Seq_ESCs_Mouse1.58376495
43PIAS1_25552417_ChIP-Seq_VCAP_Human1.56794811
44GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.56609421
45SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.55860432
46* NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.55260900
47JARID2_20075857_ChIP-Seq_MESCs_Mouse1.55127975
48AR_25329375_ChIP-Seq_VCAP_Human1.52799016
49EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.52780950
50RXR_22108803_ChIP-Seq_LS180_Human1.52514503
51* TP63_23658742_ChIP-Seq_EP156T_Human1.52312394
52ERG_20517297_ChIP-Seq_VCAP_Human1.51326442
53REST_18959480_ChIP-ChIP_MESCs_Mouse1.50430604
54TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.50214126
55GATA6_21074721_ChIP-Seq_CACO-2_Human1.49806766
56POU5F1_16153702_ChIP-ChIP_HESCs_Human1.49794234
57BCAT_22108803_ChIP-Seq_LS180_Human1.43493924
58TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.42594087
59FOXA1_21572438_ChIP-Seq_LNCaP_Human1.42072294
60GATA3_21878914_ChIP-Seq_MCF-7_Human1.41788082
61TCF3_18692474_ChIP-Seq_MEFs_Mouse1.41637376
62P300_19829295_ChIP-Seq_ESCs_Human1.41052471
63GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.40750389
64IKZF1_21737484_ChIP-ChIP_HCT116_Human1.40043690
65SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.39965669
66EZH2_27294783_Chip-Seq_ESCs_Mouse1.38638755
67* NCOR_22424771_ChIP-Seq_293T_Human1.38451496
68RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.37855565
69GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.37667166
70AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.36877719
71P53_21459846_ChIP-Seq_SAOS-2_Human1.36720730
72RING1B_27294783_Chip-Seq_NPCs_Mouse1.35558082
73TAF15_26573619_Chip-Seq_HEK293_Human1.35510796
74PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.34838107
75RARB_27405468_Chip-Seq_BRAIN_Mouse1.34461364
76POU5F1_16518401_ChIP-PET_MESCs_Mouse1.34278209
77AR_20517297_ChIP-Seq_VCAP_Human1.34119867
78SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.34028520
79E2F1_17053090_ChIP-ChIP_MCF-7_Human1.33760039
80SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.33383296
81MTF2_20144788_ChIP-Seq_MESCs_Mouse1.33291283
82NR3C1_21868756_ChIP-Seq_MCF10A_Human1.33131806
83IGF1R_20145208_ChIP-Seq_DFB_Human1.32957918
84POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.32688838
85ER_23166858_ChIP-Seq_MCF-7_Human1.32601223
86STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.32385363
87UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.30832600
88CBX2_27304074_Chip-Seq_ESCs_Mouse1.30154505
89* TAF2_19829295_ChIP-Seq_ESCs_Human1.29862460
90TCF4_22108803_ChIP-Seq_LS180_Human1.29522698
91MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.24857443
92SUZ12_27294783_Chip-Seq_ESCs_Mouse1.23824955
93EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.23811373
94EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.23120296
95CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.22991311
96VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.22694540
97CTBP1_25329375_ChIP-Seq_LNCAP_Human1.21409171
98* NANOG_18692474_ChIP-Seq_MESCs_Mouse1.19464876
99SMAD3_21741376_ChIP-Seq_EPCs_Human1.17855297
100RBPJ_21746931_ChIP-Seq_IB4_Human1.17069581
101ETV2_25802403_ChIP-Seq_MESCs_Mouse1.16351855
102ERG_21242973_ChIP-ChIP_JURKAT_Human1.16306821
103P53_22127205_ChIP-Seq_FIBROBLAST_Human1.16139920
104SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.16044082
105TP53_20018659_ChIP-ChIP_R1E_Mouse1.15649717
106SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.14714186
107ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.13072119
108BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.12898264
109SMAD4_21741376_ChIP-Seq_EPCs_Human1.11777060
110EED_16625203_ChIP-ChIP_MESCs_Mouse1.11704852
111TCF4_23295773_ChIP-Seq_U87_Human1.11338603
112STAT3_18555785_ChIP-Seq_MESCs_Mouse1.10181408
113IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.10076787
114CBP_20019798_ChIP-Seq_JUKART_Human1.10076787
115NANOG_20526341_ChIP-Seq_ESCs_Human1.09711991
116EWS_26573619_Chip-Seq_HEK293_Human1.08952623
117PCGF2_27294783_Chip-Seq_NPCs_Mouse1.08062206
118PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.07999353
119ETV1_20927104_ChIP-Seq_GIST48_Human1.07772515
120AUTS2_25519132_ChIP-Seq_293T-REX_Human1.07590550
121ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.07588622
122NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.07421349
123ERA_21632823_ChIP-Seq_H3396_Human1.07276769
124FOXH1_21741376_ChIP-Seq_EPCs_Human1.06490676
125TBX3_20139965_ChIP-Seq_MESCs_Mouse1.06240844
126KLF5_20875108_ChIP-Seq_MESCs_Mouse1.05440905
127ZNF217_24962896_ChIP-Seq_MCF-7_Human1.05376907
128TBX3_20139965_ChIP-Seq_ESCs_Mouse1.05237723
129CJUN_26792858_Chip-Seq_BT549_Human1.04881014
130HOXB7_26014856_ChIP-Seq_BT474_Human1.04839661
131* NANOG_19829295_ChIP-Seq_ESCs_Human1.04569192
132* SOX2_19829295_ChIP-Seq_ESCs_Human1.04569192
133OCT1_27270436_Chip-Seq_PROSTATE_Human1.04067293
134ZFP281_18757296_ChIP-ChIP_E14_Mouse1.04056248
135MYC_19829295_ChIP-Seq_ESCs_Human1.03990478
136EGR1_23403033_ChIP-Seq_LIVER_Mouse1.03191816
137HNFA_21074721_ChIP-Seq_CACO-2_Human1.00969934
138POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.00527762
139CDX2_22108803_ChIP-Seq_LS180_Human1.00305586
140* TP63_22573176_ChIP-Seq_HFKS_Human1.00289977
141CEBPB_22108803_ChIP-Seq_LS180_Human0.99885856
142PRDM14_20953172_ChIP-Seq_ESCs_Human0.99874532
143NANOG_18692474_ChIP-Seq_MEFs_Mouse0.99848608
144CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.99450033
145* AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.99114338
146NANOG_16518401_ChIP-PET_MESCs_Mouse0.99070371
147OCT4_20526341_ChIP-Seq_ESCs_Human0.98215248
148SMAD3_21741376_ChIP-Seq_ESCs_Human0.98125797
149TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.97820594
150CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.97525478
151RING1B_27294783_Chip-Seq_ESCs_Mouse0.97272709
152CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.97229034
153PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.96978494
154SMAD3_21741376_ChIP-Seq_HESCs_Human0.96935348
155ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.96866910
156ZFP281_27345836_Chip-Seq_ESCs_Mouse0.96543644
157TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96155102
158AHR_22903824_ChIP-Seq_MCF-7_Human0.95095813
159CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94281707
160TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93924695
161POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.93924695
162MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.93458354
163FLI1_27457419_Chip-Seq_LIVER_Mouse0.92986085
164GATA1_26923725_Chip-Seq_HPCs_Mouse0.92345393
165POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.91976626
166CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.88135754
167* POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.86715870
168ARNT_22903824_ChIP-Seq_MCF-7_Human0.85313818
169ELK4_26923725_Chip-Seq_MESODERM_Mouse0.84656726
170STAT3_23295773_ChIP-Seq_U87_Human0.82176475
171SMAD4_21799915_ChIP-Seq_A2780_Human0.82011653
172* KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.81652828
173SOX2_21211035_ChIP-Seq_LN229_Gbm0.81325097
174TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.79778363
175PCGF2_27294783_Chip-Seq_ESCs_Mouse0.79489809
176CTBP2_25329375_ChIP-Seq_LNCAP_Human0.78198649
177EOMES_21245162_ChIP-Seq_HESCs_Human0.76815667
178* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.75851342

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005275_abnormal_skin_tensile6.16277365
2MP0005501_abnormal_skin_physiology4.61828188
3MP0010234_abnormal_vibrissa_follicle4.06293713
4MP0006292_abnormal_olfactory_placode3.86071100
5MP0004858_abnormal_nervous_system2.99412534
6MP0005394_taste/olfaction_phenotype2.98963733
7MP0005499_abnormal_olfactory_system2.98963733
8MP0003878_abnormal_ear_physiology2.90477457
9MP0005377_hearing/vestibular/ear_phenot2.90477457
10MP0001216_abnormal_epidermal_layer2.89108657
11MP0003122_maternal_imprinting2.81233515
12MP0003011_delayed_dark_adaptation2.73983171
13MP0003880_abnormal_central_pattern2.72644845
14MP0002254_reproductive_system_inflammat2.70725162
15MP0002332_abnormal_exercise_endurance2.67302532
16MP0010771_integument_phenotype2.66802994
17MP0004270_analgesia2.66326427
18MP0003890_abnormal_embryonic-extraembry2.48572168
19MP0009379_abnormal_foot_pigmentation2.41703264
20MP0003453_abnormal_keratinocyte_physiol2.31766954
21MP0004264_abnormal_extraembryonic_tissu2.31292460
22MP0000427_abnormal_hair_cycle2.27117691
23MP0003941_abnormal_skin_development2.24663951
24MP0000467_abnormal_esophagus_morphology2.20825724
25MP0004859_abnormal_synaptic_plasticity2.13962776
26MP0002098_abnormal_vibrissa_morphology2.13655326
27MP0009046_muscle_twitch2.12527517
28MP0005075_abnormal_melanosome_morpholog2.06811510
29MP0002095_abnormal_skin_pigmentation2.05571226
30MP0000377_abnormal_hair_follicle2.04264319
31MP0004145_abnormal_muscle_electrophysio2.03897084
32MP0000749_muscle_degeneration2.00803146
33MP0002060_abnormal_skin_morphology1.98705489
34MP0004782_abnormal_surfactant_physiolog1.97896698
35MP0006035_abnormal_mitochondrial_morpho1.87626967
36MP0003121_genomic_imprinting1.84133889
37MP0003938_abnormal_ear_development1.82958642
38MP0001486_abnormal_startle_reflex1.81179814
39MP0003635_abnormal_synaptic_transmissio1.78537428
40MP0004381_abnormal_hair_follicle1.75728198
41MP0002572_abnormal_emotion/affect_behav1.75714248
42MP0000762_abnormal_tongue_morphology1.75174181
43MP0002064_seizures1.74588845
44MP0000566_synostosis1.72326473
45MP0002734_abnormal_mechanical_nocicepti1.71029092
46MP0004142_abnormal_muscle_tone1.70397226
47MP0004947_skin_inflammation1.70062504
48MP0003137_abnormal_impulse_conducting1.66831832
49MP0002272_abnormal_nervous_system1.62568451
50MP0005174_abnormal_tail_pigmentation1.59887830
51MP0005257_abnormal_intraocular_pressure1.56789866
52MP0002277_abnormal_respiratory_mucosa1.53019511
53MP0009745_abnormal_behavioral_response1.51215010
54MP0002063_abnormal_learning/memory/cond1.50395724
55MP0004043_abnormal_pH_regulation1.50228639
56MP0002127_abnormal_cardiovascular_syste1.46096907
57MP0001485_abnormal_pinna_reflex1.43244417
58MP0003787_abnormal_imprinting1.42619344
59MP0002653_abnormal_ependyma_morphology1.41507380
60MP0009931_abnormal_skin_appearance1.37361213
61MP0002184_abnormal_innervation1.35996594
62MP0008789_abnormal_olfactory_epithelium1.35497594
63MP0000569_abnormal_digit_pigmentation1.34629489
64MP0003136_yellow_coat_color1.33606155
65MP0008961_abnormal_basal_metabolism1.30973220
66MP0000778_abnormal_nervous_system1.29897534
67MP0002733_abnormal_thermal_nociception1.27750050
68MP0002796_impaired_skin_barrier1.27448349
69MP0000579_abnormal_nail_morphology1.25705487
70MP0000367_abnormal_coat/_hair1.24561839
71MP0001191_abnormal_skin_condition1.23160057
72MP0003950_abnormal_plasma_membrane1.22092694
73MP0000751_myopathy1.21755238
74MP0002138_abnormal_hepatobiliary_system1.21448583
75MP0005423_abnormal_somatic_nervous1.19957189
76MP0001501_abnormal_sleep_pattern1.19355432
77MP0002735_abnormal_chemical_nociception1.18961478
78MP0003195_calcinosis1.18145645
79MP0000955_abnormal_spinal_cord1.15360913
80MP0001970_abnormal_pain_threshold1.15085732
81MP0000383_abnormal_hair_follicle1.14446539
82MP0003183_abnormal_peptide_metabolism1.13871772
83MP0008057_abnormal_DNA_replication1.13669445
84MP0001440_abnormal_grooming_behavior1.12059021
85MP0002269_muscular_atrophy1.10547583
86MP0002067_abnormal_sensory_capabilities1.09313155
87MP0008875_abnormal_xenobiotic_pharmacok1.09215008
88MP0000750_abnormal_muscle_regeneration1.09006503
89MP0000678_abnormal_parathyroid_gland1.08582423
90MP0000759_abnormal_skeletal_muscle1.06940741
91MP0002752_abnormal_somatic_nervous1.06642960
92MP0002234_abnormal_pharynx_morphology1.05762287
93MP0001188_hyperpigmentation1.05075751
94MP0003755_abnormal_palate_morphology1.03838420
95MP0000049_abnormal_middle_ear1.02965818
96MP0001905_abnormal_dopamine_level1.01027076
97MP0004085_abnormal_heartbeat1.01001818
98MP0002106_abnormal_muscle_physiology0.97892154
99MP0000015_abnormal_ear_pigmentation0.97467249
100MP0004742_abnormal_vestibular_system0.96002323
101MP0004885_abnormal_endolymph0.95295594
102MP0005369_muscle_phenotype0.94582874
103MP0000647_abnormal_sebaceous_gland0.93904962
104MP0002233_abnormal_nose_morphology0.93112411
105MP0004215_abnormal_myocardial_fiber0.92417024
106MP0002882_abnormal_neuron_morphology0.91641508
107MP0001968_abnormal_touch/_nociception0.90855638
108MP0003123_paternal_imprinting0.90511690
109MP0005620_abnormal_muscle_contractility0.89738091
110MP0005171_absent_coat_pigmentation0.88618079
111MP0002837_dystrophic_cardiac_calcinosis0.87918172
112MP0002114_abnormal_axial_skeleton0.86966733
113MP0003646_muscle_fatigue0.85419834
114MP0005551_abnormal_eye_electrophysiolog0.84890398
115MP0006276_abnormal_autonomic_nervous0.83965598
116MP0002751_abnormal_autonomic_nervous0.83575277
117MP0000372_irregular_coat_pigmentation0.82541986
118MP0005266_abnormal_metabolism0.80922645
119MP0000747_muscle_weakness0.78705012
120MP0005623_abnormal_meninges_morphology0.78469755
121MP0005253_abnormal_eye_physiology0.78210229
122MP0008872_abnormal_physiological_respon0.77789221
123MP0005645_abnormal_hypothalamus_physiol0.77277735
124MP0001963_abnormal_hearing_physiology0.76089872
125MP0002932_abnormal_joint_morphology0.75957528
126MP0010678_abnormal_skin_adnexa0.75136250
127MP0003638_abnormal_response/metabolism_0.74451107
128MP0002066_abnormal_motor_capabilities/c0.73966579
129MP0001984_abnormal_olfaction0.73917807
130MP0008877_abnormal_DNA_methylation0.73625253
131MP0005409_darkened_coat_color0.73175393
132MP0004036_abnormal_muscle_relaxation0.72204678
133MP0002557_abnormal_social/conspecific_i0.72093506
134MP0005330_cardiomyopathy0.70100558
135MP0002229_neurodegeneration0.70012389
136MP0002736_abnormal_nociception_after0.69540851
137MP0001529_abnormal_vocalization0.69027884
138MP0003861_abnormal_nervous_system0.68059130
139MP0001784_abnormal_fluid_regulation0.67707718
140MP0000465_gastrointestinal_hemorrhage0.64253669
141MP0006072_abnormal_retinal_apoptosis0.61290432
142MP0003191_abnormal_cellular_cholesterol0.58130437
143MP0002282_abnormal_trachea_morphology0.54447253
144MP0001243_abnormal_dermal_layer0.52282551
145MP0002102_abnormal_ear_morphology0.48997256
146MP0002938_white_spotting0.48164001
147MP0009053_abnormal_anal_canal0.47139335
148MP0001502_abnormal_circadian_rhythm0.46372212
149MP0005646_abnormal_pituitary_gland0.45837405
150MP0001851_eye_inflammation0.45793205
151MP0009780_abnormal_chondrocyte_physiolo0.43924140
152MP0002177_abnormal_outer_ear0.43698152
153MP0002909_abnormal_adrenal_gland0.41959318
154MP0001765_abnormal_ion_homeostasis0.39561992
155MP0005410_abnormal_fertilization0.38085445
156MP0002638_abnormal_pupillary_reflex0.37829972
157MP0000026_abnormal_inner_ear0.37782441
158MP0001177_atelectasis0.33448331
159MP0004924_abnormal_behavior0.33421399
160MP0005386_behavior/neurological_phenoty0.33421399
161MP0004147_increased_porphyrin_level0.32954746
162MP0000631_abnormal_neuroendocrine_gland0.31648903
163MP0002111_abnormal_tail_morphology0.29909584

Predicted human phenotypes

RankGene SetZ-score
1Palmoplantar hyperkeratosis (HP:0000972)7.89738729
2Erythroderma (HP:0001019)7.61672357
3Palmar hyperkeratosis (HP:0010765)7.52328354
4Increased IgE level (HP:0003212)7.27206981
5Congenital nonbullous ichthyosiform erythroderma (HP:0007479)6.54448370
6Congenital ichthyosiform erythroderma (HP:0007431)6.53720048
7Plantar hyperkeratosis (HP:0007556)6.34573949
8Bilateral microphthalmos (HP:0007633)6.29768682
9Abnormality of the axillary hair (HP:0100134)6.05938063
10Abnormality of secondary sexual hair (HP:0009888)6.05938063
11Alopecia of scalp (HP:0002293)6.01251413
12Hypotrichosis (HP:0001006)5.63088336
13Onycholysis (HP:0001806)5.53908545
14Oral leukoplakia (HP:0002745)5.53398056
15Parakeratosis (HP:0001036)5.35962795
16Thick nail (HP:0001805)5.32018047
17Conjunctival hamartoma (HP:0100780)5.17724088
18Corneal erosion (HP:0200020)5.13758856
19Erythema (HP:0010783)4.98732616
20Hypochromic microcytic anemia (HP:0004840)4.63351726
21Hyperventilation (HP:0002883)4.23384841
22Hepatoblastoma (HP:0002884)4.08000247
23Abnormality of the lower motor neuron (HP:0002366)4.03710460
24Woolly hair (HP:0002224)3.97322166
25Gangrene (HP:0100758)3.96221119
26Furrowed tongue (HP:0000221)3.94820190
27Sensory axonal neuropathy (HP:0003390)3.92882793
28Palmoplantar keratoderma (HP:0000982)3.90260225
29Hypohidrosis (HP:0000966)3.86718508
30Ectropion (HP:0000656)3.76222967
31Hamartoma of the eye (HP:0010568)3.72630582
32Febrile seizures (HP:0002373)3.70253408
33Epileptic encephalopathy (HP:0200134)3.48686651
34Hypoplasia of the fovea (HP:0007750)3.43421031
35Aplasia/Hypoplasia of the fovea (HP:0008060)3.43421031
36Difficulty running (HP:0009046)3.42832238
37Rib fusion (HP:0000902)3.40813453
38Absent hair (HP:0002298)3.24091687
39Focal motor seizures (HP:0011153)3.20459258
40Sparse eyelashes (HP:0000653)3.14538485
41Chromosomal breakage induced by crosslinking agents (HP:0003221)3.13523287
42Nephroblastoma (Wilms tumor) (HP:0002667)3.07420631
43Anomalous pulmonary venous return (HP:0010772)3.06642663
44Nail dystrophy (HP:0008404)3.04028317
45Amblyopia (HP:0000646)3.03237138
46Testicular atrophy (HP:0000029)2.99429218
47Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.96152126
48Abnormal blistering of the skin (HP:0008066)2.88896219
49Absent eyelashes (HP:0000561)2.88227820
50Atonic seizures (HP:0010819)2.85979513
51Pruritus (HP:0000989)2.84721682
52Right ventricular cardiomyopathy (HP:0011663)2.84017749
53Embryonal renal neoplasm (HP:0011794)2.83120277
54Multiple enchondromatosis (HP:0005701)2.81251825
55Bifid tongue (HP:0010297)2.75504617
56Follicular hyperkeratosis (HP:0007502)2.71915700
57Abnormality of the salivary glands (HP:0010286)2.71680593
58Horizontal nystagmus (HP:0000666)2.69516694
59Fragile nails (HP:0001808)2.68706481
60Abnormality of the fovea (HP:0000493)2.67382351
61Rectal fistula (HP:0100590)2.65546486
62Rectovaginal fistula (HP:0000143)2.65546486
63Dialeptic seizures (HP:0011146)2.64218773
64Hemiparesis (HP:0001269)2.63826819
65Focal seizures (HP:0007359)2.61331762
66Abnormality of nail color (HP:0100643)2.57845250
67Ependymoma (HP:0002888)2.57489616
68Abnormality of the pulmonary veins (HP:0011718)2.55714001
69Abnormal hair laboratory examination (HP:0003328)2.55272638
70Amyotrophic lateral sclerosis (HP:0007354)2.55100813
71Pili torti (HP:0003777)2.54371151
72Pustule (HP:0200039)2.52881413
73Exercise-induced muscle cramps (HP:0003710)2.52755383
74Generalized hypotonia (HP:0001290)2.50151377
75Progressive external ophthalmoplegia (HP:0000590)2.48248610
76Partial duplication of thumb phalanx (HP:0009944)2.45329728
77Chromsome breakage (HP:0040012)2.45050642
78Nasolacrimal duct obstruction (HP:0000579)2.43900979
79Preauricular pit (HP:0004467)2.43838937
80Periauricular skin pits (HP:0100277)2.43838937
81Abnormality of the corticospinal tract (HP:0002492)2.42537056
82Fused cervical vertebrae (HP:0002949)2.42357050
83Slow-growing hair (HP:0002217)2.38713363
84Abnormality of hair growth rate (HP:0011363)2.38713363
85Neoplasm of striated muscle (HP:0009728)2.37340441
86Lip pit (HP:0100267)2.36829710
87Sparse scalp hair (HP:0002209)2.35638479
88Ragged-red muscle fibers (HP:0003200)2.34050478
89Abnormality of placental membranes (HP:0011409)2.33643565
90Amniotic constriction ring (HP:0009775)2.33643565
91Progressive muscle weakness (HP:0003323)2.33270120
92Brittle hair (HP:0002299)2.31310435
93Increased connective tissue (HP:0009025)2.30240924
94Concave nail (HP:0001598)2.26751558
95Intestinal fistula (HP:0100819)2.22643053
96Exercise-induced myalgia (HP:0003738)2.21217692
97Conical tooth (HP:0000698)2.20891053
98Hyperinsulinemic hypoglycemia (HP:0000825)2.20312933
99Aplasia/hypoplasia of the humerus (HP:0006507)2.16997072
100Abnormality of chromosome segregation (HP:0002916)2.16624315
101Muscle hypertrophy of the lower extremities (HP:0008968)2.16540828
102Generalized tonic-clonic seizures (HP:0002069)2.15899191
103Recurrent corneal erosions (HP:0000495)2.15639500
104Short humerus (HP:0005792)2.14759906
105Duplicated collecting system (HP:0000081)2.14673083
106Abnormality of glycolysis (HP:0004366)2.13706950
107Increased serum pyruvate (HP:0003542)2.13706950
108Pancreatic cysts (HP:0001737)2.12049790
109Melanocytic nevus (HP:0000995)2.11083264
110Abnormality of the pubic bones (HP:0003172)2.07413645
111Hypoplastic labia majora (HP:0000059)2.06593140
112Increased variability in muscle fiber diameter (HP:0003557)2.05973953
113Blepharitis (HP:0000498)2.05233688
1143-Methylglutaconic aciduria (HP:0003535)2.03935934
115Partial duplication of the phalanx of hand (HP:0009999)2.02854590
116Rhabdomyosarcoma (HP:0002859)2.02487985
117Muscle fiber inclusion bodies (HP:0100299)2.01687556
118Tetraplegia (HP:0002445)2.00857349
119Fair hair (HP:0002286)1.99687254
120Abnormality of the astrocytes (HP:0100707)1.96632012
121Astrocytoma (HP:0009592)1.96632012
122Abnormality of the phalanges of the hallux (HP:0010057)1.96527084
123Inability to walk (HP:0002540)1.96258635
124Abnormal lung lobation (HP:0002101)1.95434922
125Vaginal fistula (HP:0004320)1.95248018
126Large earlobe (HP:0009748)1.93187495
127Abnormality of the renal collecting system (HP:0004742)1.93089899
128Congenital, generalized hypertrichosis (HP:0004540)1.92603565
129Abnormality of the lacrimal duct (HP:0011481)1.92592410
130EMG: neuropathic changes (HP:0003445)1.92117189
131Shawl scrotum (HP:0000049)1.91972969
132EMG: myopathic abnormalities (HP:0003458)1.91892683
133Lack of skin elasticity (HP:0100679)1.90866451
134Dehydration (HP:0001944)1.90300667
135Aplasia/Hypoplasia of the macula (HP:0008059)1.89756020
136Pancreatic fibrosis (HP:0100732)1.89166402
137Aplasia/Hypoplasia affecting the retina (HP:0008061)1.88854830
138Absence seizures (HP:0002121)1.87655368
139Upper limb muscle weakness (HP:0003484)1.87235181
140Abnormality of midbrain morphology (HP:0002418)1.86966975
141Molar tooth sign on MRI (HP:0002419)1.86966975
142Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.86504354
143Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.85814119
144Abnormality of the labia majora (HP:0012881)1.85789649
145Drooling (HP:0002307)1.85535093
146Excessive salivation (HP:0003781)1.85535093
147Skin pits (HP:0100276)1.85284203
148Spastic tetraparesis (HP:0001285)1.85213073
149Calf muscle hypertrophy (HP:0008981)1.84076149
150Myotonia (HP:0002486)1.83332260
151Keratoconjunctivitis (HP:0001096)1.83000954
152Supernumerary spleens (HP:0009799)1.81328582
153Mildly elevated creatine phosphokinase (HP:0008180)1.81142724
154Ridged nail (HP:0001807)1.79449122
155Abnormality of skeletal muscle fiber size (HP:0012084)1.79034038
156Keratoconjunctivitis sicca (HP:0001097)1.78856180
157Abnormality of the labia minora (HP:0012880)1.78501058
158True hermaphroditism (HP:0010459)1.78434387
159Achilles tendon contracture (HP:0001771)1.76759137
160Nemaline bodies (HP:0003798)1.76529382
161Myokymia (HP:0002411)1.76214697
162Milia (HP:0001056)1.76070525
163Generalized myoclonic seizures (HP:0002123)1.75813107
164Congenital stationary night blindness (HP:0007642)1.72959117
165Curly hair (HP:0002212)1.71857059
166Ventricular tachycardia (HP:0004756)1.71853159
167Hamartoma (HP:0010566)1.70719841
168Paralysis (HP:0003470)1.68975834
169Tubular atrophy (HP:0000092)1.67421736
170Laryngomalacia (HP:0001601)1.66304024
171Type II lissencephaly (HP:0007260)1.66110891
172Abnormality of the renal cortex (HP:0011035)1.63860474
173Hypergammaglobulinemia (HP:0010702)1.63216083
174Fine hair (HP:0002213)1.63002627
175Dry skin (HP:0000958)1.62653893
176Abnormality of the neuromuscular junction (HP:0003398)1.62418886
177Fatigable weakness (HP:0003473)1.62418886
178Nephronophthisis (HP:0000090)1.62181004
179Hyperhidrosis (HP:0000975)1.62176267
180Generalized hypopigmentation of hair (HP:0011358)1.62006962
181Attenuation of retinal blood vessels (HP:0007843)1.61944105
182Anonychia (HP:0001798)1.60419519
183Dry hair (HP:0011359)1.59501867
184Polydipsia (HP:0001959)1.57978289
185Abnormal drinking behavior (HP:0030082)1.57978289
186Breast hypoplasia (HP:0003187)1.54709400
187Gaze-evoked nystagmus (HP:0000640)1.52612976
188Multifactorial inheritance (HP:0001426)1.52357315
189Corneal dystrophy (HP:0001131)1.48786500
190Abnormality of alanine metabolism (HP:0010916)1.48580724
191Hyperalaninemia (HP:0003348)1.48580724
192Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.48580724
193Abnormality of the renal medulla (HP:0100957)1.47778828
194Amelogenesis imperfecta (HP:0000705)1.47517901
195Xerostomia (HP:0000217)1.45831580
196Widely spaced teeth (HP:0000687)1.44129283
197Abnormality of the dental pulp (HP:0006479)1.43356200
198Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.42918923

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK125.61573555
2GRK55.57952124
3FRK5.57325882
4TGFBR13.91773928
5INSRR3.51948113
6ADRBK23.05931136
7GRK12.98193026
8GRK62.88245195
9GRK72.84425598
10TLK12.72801109
11BMPR1B2.64129593
12CASK2.46630209
13MAPKAPK32.45438653
14MAP3K92.44111755
15TYRO32.40447878
16MAPK72.39915616
17AKT32.21444998
18ACVR1B2.18503866
19ZAK2.12855948
20WNK12.09914938
21EPHA32.09168954
22FER2.08858779
23IRAK12.02710435
24MAP2K41.97076084
25MAP4K21.95713986
26NTRK31.91825822
27NTRK11.82078978
28EPHA41.81474788
29CSF1R1.80852422
30WNK41.73360098
31MOS1.71256163
32MARK11.70672492
33MATK1.65348150
34ERN11.61164300
35PHKG11.60144406
36PHKG21.60144406
37TTK1.53480534
38OBSCN1.51354351
39IKBKB1.45506733
40MARK21.39509034
41WNK31.34528446
42STK241.29610099
43TRPM71.29461736
44MAPK121.26150680
45NUAK11.24224676
46TAOK31.21821093
47TGFBR21.20792259
48MAP3K41.19724623
49CAMK41.18827230
50FGFR11.18493438
51ADRBK11.16211184
52SGK2231.12878269
53SGK4941.12878269
54NLK1.12590591
55PAK61.11009001
56NME11.10906407
57STK38L1.10590231
58PRPF4B1.09960219
59PRKCE1.08445001
60CDK191.08206608
61TXK1.07531812
62NTRK21.06381040
63LATS21.06201022
64TIE11.05356295
65MKNK21.03816676
66MAP2K71.03237993
67BCKDK1.02900944
68FGFR21.01076108
69DYRK21.01022249
70STK31.00081227
71OXSR10.99884203
72PIK3CA0.95867259
73LATS10.92789240
74KIT0.86036714
75PRKCG0.79739471
76MST40.79267965
77PTK2B0.79110778
78CAMK1D0.77349060
79PKN10.77030530
80CHEK20.76909514
81FGFR30.76544022
82MAP2K60.76366103
83MAPK150.75835414
84PRKG20.72593820
85CAMK1G0.71949375
86PDK30.71593178
87PDK40.71593178
88BRSK20.71128507
89STK390.70859749
90PLK20.66143203
91PIK3CG0.63689308
92MAPK130.62484013
93PAK30.62261147
94PRKAA20.62256718
95HIPK20.61604971
96DYRK1A0.61340866
97MAP3K70.59972045
98PDK20.59947951
99TNIK0.59193110
100MAP3K20.59134511
101PINK10.58231991
102CDK70.57049873
103ITK0.56216553
104AKT20.54926383
105STK100.52765091
106CDK150.52696889
107SGK20.51502029
108EIF2AK30.51308505
109CDK50.50895557
110CDK180.50252666
111FLT30.49232194
112CAMK2A0.48952642
113MET0.48891683
114EIF2AK20.48378988
115BCR0.48299965
116PRKACA0.47904643
117CDK11A0.47562422
118STK380.46847631
119PLK10.46782012
120MAPK100.46462630
121PRKACB0.46027881
122MKNK10.45296740
123DAPK20.43869023
124MUSK0.43755822
125UHMK10.43712757
126CDK140.42983766
127CAMKK20.41665807
128ALK0.40835238
129CHUK0.39728535
130PRKCI0.39336389
131MAPKAPK50.38919216
132PRKCQ0.38670813
133MAP2K10.38541872
134EEF2K0.38320041
135CSNK1E0.37570304
136EPHA20.36950111
137PRKAA10.35039013
138ERBB30.34485972
139FGR0.34052982
140CDK30.34032330
141MAP3K130.33925094
142SIK20.33330006
143MINK10.33225030
144NEK60.32454242
145IKBKE0.32308104
146CSNK1G10.31543270
147TEC0.31167451
148KSR20.30878822
149PNCK0.30765753
150STK160.30581795
151SGK10.30554005
152CHEK10.30476139
153RIPK40.30267587
154RPS6KA50.29957739
155WEE10.29367827
156RPS6KA30.28947796
157CCNB10.28749804
158PRKD20.28043815
159PRKG10.27173662
160MAP3K60.26378187
161BMPR20.25755623
162TNK20.25557074
163GSK3B0.25347122
164MAPK40.24009854
165PRKACG0.23940726

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007505.33707812
2Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006034.80008614
3Nicotine addiction_Homo sapiens_hsa050332.86507143
4Nitrogen metabolism_Homo sapiens_hsa009102.56112627
5GABAergic synapse_Homo sapiens_hsa047272.43308557
6Fructose and mannose metabolism_Homo sapiens_hsa000512.32600225
7Taste transduction_Homo sapiens_hsa047422.11531891
8Cardiac muscle contraction_Homo sapiens_hsa042602.10875865
9* Glutamatergic synapse_Homo sapiens_hsa047242.03955228
10Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.00421665
11* Serotonergic synapse_Homo sapiens_hsa047261.96724909
12Synaptic vesicle cycle_Homo sapiens_hsa047211.94563834
13Histidine metabolism_Homo sapiens_hsa003401.94199683
14Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.69312456
15Morphine addiction_Homo sapiens_hsa050321.63261070
16Long-term potentiation_Homo sapiens_hsa047201.60845784
17Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.59814526
18Circadian entrainment_Homo sapiens_hsa047131.57394165
19Calcium signaling pathway_Homo sapiens_hsa040201.52107807
20Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.50957676
21Intestinal immune network for IgA production_Homo sapiens_hsa046721.49690504
22Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.49414656
23Sphingolipid metabolism_Homo sapiens_hsa006001.48759365
24Salivary secretion_Homo sapiens_hsa049701.48565403
25Caffeine metabolism_Homo sapiens_hsa002321.48038669
26* Arachidonic acid metabolism_Homo sapiens_hsa005901.47642224
27Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.43611521
28* Long-term depression_Homo sapiens_hsa047301.43069936
29Tryptophan metabolism_Homo sapiens_hsa003801.41568329
30Dilated cardiomyopathy_Homo sapiens_hsa054141.39980944
31Collecting duct acid secretion_Homo sapiens_hsa049661.39509168
32Oxidative phosphorylation_Homo sapiens_hsa001901.39299324
33Butanoate metabolism_Homo sapiens_hsa006501.38973847
34Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.37645666
35* Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.33055053
36Asthma_Homo sapiens_hsa053101.31340376
37Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.27043751
38* Oxytocin signaling pathway_Homo sapiens_hsa049211.26516129
39Axon guidance_Homo sapiens_hsa043601.26483658
40Fat digestion and absorption_Homo sapiens_hsa049751.26198182
41Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.25832210
42Cyanoamino acid metabolism_Homo sapiens_hsa004601.25047801
43Maturity onset diabetes of the young_Homo sapiens_hsa049501.23770051
44Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.21325874
45Staphylococcus aureus infection_Homo sapiens_hsa051501.19767993
46Retinol metabolism_Homo sapiens_hsa008301.18648395
47Dopaminergic synapse_Homo sapiens_hsa047281.18474384
48Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.15202190
49* Phospholipase D signaling pathway_Homo sapiens_hsa040721.12555139
50Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.11654209
51Renin secretion_Homo sapiens_hsa049241.09917600
52Amphetamine addiction_Homo sapiens_hsa050311.09841305
53ABC transporters_Homo sapiens_hsa020101.09743760
54Galactose metabolism_Homo sapiens_hsa000521.09629885
55Regulation of autophagy_Homo sapiens_hsa041401.08975369
56Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.08619542
57Steroid hormone biosynthesis_Homo sapiens_hsa001401.07422629
58Phosphatidylinositol signaling system_Homo sapiens_hsa040701.05246839
59Alzheimers disease_Homo sapiens_hsa050101.03815458
60Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.03341756
61* Ether lipid metabolism_Homo sapiens_hsa005651.02701629
62beta-Alanine metabolism_Homo sapiens_hsa004101.00780878
63Olfactory transduction_Homo sapiens_hsa047400.99664494
64* GnRH signaling pathway_Homo sapiens_hsa049120.99391311
65cAMP signaling pathway_Homo sapiens_hsa040240.98739900
66Selenocompound metabolism_Homo sapiens_hsa004500.97734741
67Inositol phosphate metabolism_Homo sapiens_hsa005620.96821536
68* Choline metabolism in cancer_Homo sapiens_hsa052310.96246282
69Insulin secretion_Homo sapiens_hsa049110.95985496
70Gap junction_Homo sapiens_hsa045400.95450159
71* Vascular smooth muscle contraction_Homo sapiens_hsa042700.95395632
72Mineral absorption_Homo sapiens_hsa049780.92954747
73* Linoleic acid metabolism_Homo sapiens_hsa005910.92385675
74Dorso-ventral axis formation_Homo sapiens_hsa043200.91025088
75Parkinsons disease_Homo sapiens_hsa050120.90591863
76mTOR signaling pathway_Homo sapiens_hsa041500.89902422
77Cholinergic synapse_Homo sapiens_hsa047250.88452917
78Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.88015948
79* Glycerophospholipid metabolism_Homo sapiens_hsa005640.87779277
80Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.85135107
81Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.84775739
82ErbB signaling pathway_Homo sapiens_hsa040120.83121795
83Chemical carcinogenesis_Homo sapiens_hsa052040.82419928
84Glycerolipid metabolism_Homo sapiens_hsa005610.81767516
85Gastric acid secretion_Homo sapiens_hsa049710.78965579
86* Ovarian steroidogenesis_Homo sapiens_hsa049130.76894326
87Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.76803860
88Fatty acid elongation_Homo sapiens_hsa000620.76133143
89Rap1 signaling pathway_Homo sapiens_hsa040150.74369909
90* Ras signaling pathway_Homo sapiens_hsa040140.73474610
91* alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.72608876
92cGMP-PKG signaling pathway_Homo sapiens_hsa040220.72159952
93Fatty acid biosynthesis_Homo sapiens_hsa000610.71895876
94Hedgehog signaling pathway_Homo sapiens_hsa043400.70937536
95Regulation of actin cytoskeleton_Homo sapiens_hsa048100.70244617
96Huntingtons disease_Homo sapiens_hsa050160.67437877
97Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.66965796
98* MAPK signaling pathway_Homo sapiens_hsa040100.66753106
99Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.66152121
100Tight junction_Homo sapiens_hsa045300.64887768
101Allograft rejection_Homo sapiens_hsa053300.63152165
102Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.62663277
103Phototransduction_Homo sapiens_hsa047440.62256360
104Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.61992708
105Primary bile acid biosynthesis_Homo sapiens_hsa001200.61742836
106Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.61578175
107African trypanosomiasis_Homo sapiens_hsa051430.61194702
108Sulfur relay system_Homo sapiens_hsa041220.58953712
109Type I diabetes mellitus_Homo sapiens_hsa049400.57921063
110Cocaine addiction_Homo sapiens_hsa050300.57566156
111Graft-versus-host disease_Homo sapiens_hsa053320.56978981
112Steroid biosynthesis_Homo sapiens_hsa001000.56810442
113Pancreatic secretion_Homo sapiens_hsa049720.55966136
114Wnt signaling pathway_Homo sapiens_hsa043100.55796728
115Peroxisome_Homo sapiens_hsa041460.55237863
116Autoimmune thyroid disease_Homo sapiens_hsa053200.53542740
117* Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.53483430
118Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.52554497
119Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.50977849
120Fanconi anemia pathway_Homo sapiens_hsa034600.50377741
121Melanogenesis_Homo sapiens_hsa049160.49305395
122Aldosterone synthesis and secretion_Homo sapiens_hsa049250.48436741
123Sphingolipid signaling pathway_Homo sapiens_hsa040710.48355780
124Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.47166922
125Oocyte meiosis_Homo sapiens_hsa041140.46975883
126Thyroid hormone signaling pathway_Homo sapiens_hsa049190.46811835
127Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.46017615
128Renal cell carcinoma_Homo sapiens_hsa052110.45188088
129Protein export_Homo sapiens_hsa030600.45081171
130Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.44437074
131NOD-like receptor signaling pathway_Homo sapiens_hsa046210.43811398
132Propanoate metabolism_Homo sapiens_hsa006400.42433731
133Rheumatoid arthritis_Homo sapiens_hsa053230.41558172
134Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.39655165
135RNA polymerase_Homo sapiens_hsa030200.39191509
136Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.38642091
137Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.37713032
138Pentose and glucuronate interconversions_Homo sapiens_hsa000400.37236335
139Vitamin digestion and absorption_Homo sapiens_hsa049770.34224174
140Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.32045927
141Longevity regulating pathway - mammal_Homo sapiens_hsa042110.31447564
142* Metabolic pathways_Homo sapiens_hsa011000.30942365
143Circadian rhythm_Homo sapiens_hsa047100.29809942
144Estrogen signaling pathway_Homo sapiens_hsa049150.28527403
145Carbohydrate digestion and absorption_Homo sapiens_hsa049730.28306716
146Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.28292726
147Basal transcription factors_Homo sapiens_hsa030220.28033496
148Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.27883986
149Basal cell carcinoma_Homo sapiens_hsa052170.27625780
150Arginine and proline metabolism_Homo sapiens_hsa003300.25693222
151Homologous recombination_Homo sapiens_hsa034400.25058443
152PPAR signaling pathway_Homo sapiens_hsa033200.23830302
153Jak-STAT signaling pathway_Homo sapiens_hsa046300.23370692

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