PLA2G4F

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1establishment of skin barrier (GO:0061436)8.90824960
2keratinization (GO:0031424)8.51026698
3regulation of water loss via skin (GO:0033561)8.26145763
4interferon-gamma secretion (GO:0072643)7.46407726
5keratinocyte differentiation (GO:0030216)6.01329102
6multicellular organismal water homeostasis (GO:0050891)5.65486110
7sphingoid metabolic process (GO:0046519)5.63292370
8linoleic acid metabolic process (GO:0043651)5.61685429
9daunorubicin metabolic process (GO:0044597)5.34712761
10polyketide metabolic process (GO:0030638)5.34712761
11doxorubicin metabolic process (GO:0044598)5.34712761
12molting cycle (GO:0042303)5.25036087
13hair cycle (GO:0042633)5.25036087
14long-chain fatty acid biosynthetic process (GO:0042759)5.20981167
15diol metabolic process (GO:0034311)5.12722694
16lipoxygenase pathway (GO:0019372)5.09872372
17hemidesmosome assembly (GO:0031581)4.90676931
18sphingosine metabolic process (GO:0006670)4.88335478
19water homeostasis (GO:0030104)4.83754283
20negative regulation of interleukin-2 production (GO:0032703)4.83122358
21keratinocyte proliferation (GO:0043616)4.80651466
22ribosomal small subunit biogenesis (GO:0042274)4.60664648
23bundle of His cell to Purkinje myocyte communication (GO:0086069)4.57697624
24epidermal cell differentiation (GO:0009913)4.55178912
25regulation of mammary gland epithelial cell proliferation (GO:0033599)4.54379005
26somite rostral/caudal axis specification (GO:0032525)4.47167073
27regulation of response to osmotic stress (GO:0047484)4.46346850
28regulation of MHC class I biosynthetic process (GO:0045343)4.27180462
29alpha-beta T cell activation involved in immune response (GO:0002287)4.20835898
30T cell differentiation involved in immune response (GO:0002292)4.20835898
31alpha-beta T cell differentiation involved in immune response (GO:0002293)4.20835898
32regulation of ruffle assembly (GO:1900027)4.13813200
33peptide cross-linking (GO:0018149)4.10209427
34regulation of hypersensitivity (GO:0002883)4.09953299
35muscle organ morphogenesis (GO:0048644)4.05932119
36negative regulation of epidermis development (GO:0045683)4.05681011
37intestinal epithelial cell development (GO:0060576)4.02541830
38ectoderm development (GO:0007398)4.00506628
39cellular response to nitric oxide (GO:0071732)3.99913432
40intermediate filament organization (GO:0045109)3.96823649
41glucosamine-containing compound catabolic process (GO:1901072)3.92696660
42one-carbon compound transport (GO:0019755)3.89535527
43CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)3.88763122
44T-helper cell differentiation (GO:0042093)3.88763122
45epidermis development (GO:0008544)3.80469369
46regulation of chemokine secretion (GO:0090196)3.79339850
47* phosphatidylserine acyl-chain remodeling (GO:0036150)3.77110400
48cyclooxygenase pathway (GO:0019371)3.65119484
49intermediate filament cytoskeleton organization (GO:0045104)3.60296773
50positive regulation of interleukin-8 secretion (GO:2000484)3.58480650
51NIK/NF-kappaB signaling (GO:0038061)3.57963992
52viral transcription (GO:0019083)3.55616278
53hormone catabolic process (GO:0042447)3.54938418
54intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator (GO:0042771)3.50759471
55regulation of keratinocyte differentiation (GO:0045616)3.50101419
56cytidine metabolic process (GO:0046087)3.47964689
57cytidine catabolic process (GO:0006216)3.47964689
58cytidine deamination (GO:0009972)3.47964689
59intermediate filament-based process (GO:0045103)3.47428693
60primary alcohol catabolic process (GO:0034310)3.47336475
61positive regulation of interleukin-4 production (GO:0032753)3.45107479
62* phosphatidylinositol acyl-chain remodeling (GO:0036149)3.41956316
63epithelial cell-cell adhesion (GO:0090136)3.40085437
64cellular response to reactive nitrogen species (GO:1902170)3.38084464
65polarized epithelial cell differentiation (GO:0030859)3.34673426
66maintenance of protein location in nucleus (GO:0051457)3.33389544
67transepithelial transport (GO:0070633)3.33048221
68endothelial cell chemotaxis (GO:0035767)3.31581195
69negative regulation of epidermal cell differentiation (GO:0045605)3.30704776
70gap junction assembly (GO:0016264)3.29731440
71translational termination (GO:0006415)3.28588401
72aminoglycoside antibiotic metabolic process (GO:0030647)3.26376228
73ventricular cardiac muscle cell action potential (GO:0086005)3.25623995
74atrioventricular valve morphogenesis (GO:0003181)3.20401920
75surfactant homeostasis (GO:0043129)3.16967358
76regulation of phospholipase A2 activity (GO:0032429)3.16494304
77regulation of cell proliferation involved in kidney development (GO:1901722)3.13675542
78cellular response to interferon-alpha (GO:0035457)3.12919676
79regulation of apoptotic process involved in morphogenesis (GO:1902337)3.09765806
80positive regulation of epidermal cell differentiation (GO:0045606)3.08326486
81negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)3.07004081
82keratinocyte development (GO:0003334)3.05971342
83regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.05706026
84polyol transport (GO:0015791)3.04796345
85renal system process involved in regulation of blood volume (GO:0001977)3.04396465
86regulation of keratinocyte proliferation (GO:0010837)3.01756087
87positive regulation of keratinocyte differentiation (GO:0045618)3.00585520
88calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.00120197
89regulation of epidermis development (GO:0045682)3.00021287
90regulation of cholesterol homeostasis (GO:2000188)2.97969698
91skin morphogenesis (GO:0043589)2.95874387
92response to nitric oxide (GO:0071731)2.95455082
93establishment of planar polarity (GO:0001736)2.92550420
94establishment of tissue polarity (GO:0007164)2.92550420
95intrinsic apoptotic signaling pathway by p53 class mediator (GO:0072332)2.91847306
96* phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.91322173
97chemical homeostasis within a tissue (GO:0048875)2.90842907
98T cell activation involved in immune response (GO:0002286)2.89555249
99negative regulation of interferon-gamma production (GO:0032689)2.89217720
100* phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.88809397
101trophectodermal cell differentiation (GO:0001829)2.88724983
102negative regulation of cell fate commitment (GO:0010454)2.87100856
103notochord development (GO:0030903)2.85416477
104* phosphatidylcholine acyl-chain remodeling (GO:0036151)2.85306913
105positive regulation of epidermis development (GO:0045684)2.82881051
106detection of bacterium (GO:0016045)2.80676482
107iron ion import (GO:0097286)2.80187860
108negative regulation by host of viral transcription (GO:0043922)2.79092659
109fatty acid elongation (GO:0030497)2.79040581
110cardiac right ventricle morphogenesis (GO:0003215)2.76724938
111antigen processing and presentation of endogenous antigen (GO:0019883)2.76496070
112antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.74070716
113antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.74070716
114regulation of interleukin-8 secretion (GO:2000482)2.73934026
115alpha-beta T cell activation (GO:0046631)2.72067716
116negative regulation of cell cycle G2/M phase transition (GO:1902750)2.70710556
117regulation of protein localization to cell surface (GO:2000008)2.69596773
118negative regulation of keratinocyte proliferation (GO:0010839)2.68334755
119fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.68177870
120lung lobe morphogenesis (GO:0060463)2.67845007
121interferon-gamma production (GO:0032609)2.67728445
122renal absorption (GO:0070293)2.67521121
123branching involved in mammary gland duct morphogenesis (GO:0060444)2.67345975
124cell-cell junction assembly (GO:0007043)2.66298647
125establishment of endothelial barrier (GO:0061028)2.65759646
126hair follicle morphogenesis (GO:0031069)2.64539290
127regulation of integrin-mediated signaling pathway (GO:2001044)2.64119947
128negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.62866455
129ethanol metabolic process (GO:0006067)2.62597090
130epithelial cell maturation (GO:0002070)2.62332298
131epithelium development (GO:0060429)2.62108813
132epithelial cell differentiation involved in prostate gland development (GO:0060742)2.61210896
133very long-chain fatty acid metabolic process (GO:0000038)2.60393232
134alpha-beta T cell differentiation (GO:0046632)2.59032062
135viral life cycle (GO:0019058)2.58603265
136lateral sprouting from an epithelium (GO:0060601)2.58402341
137* phosphatidylserine metabolic process (GO:0006658)2.58136733
138regulation of interleukin-4 production (GO:0032673)2.58013798
139nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.55921139
140negative regulation of necroptotic process (GO:0060546)2.54926236
141branching involved in labyrinthine layer morphogenesis (GO:0060670)2.54543100
142positive regulation of chemokine secretion (GO:0090197)2.53693665
143regulation of histone H3-K27 methylation (GO:0061085)2.52822019
144detection of other organism (GO:0098543)2.47209817
145phospholipid efflux (GO:0033700)2.47162171
146regulation of glomerular filtration (GO:0003093)2.46072080
147skeletal muscle adaptation (GO:0043501)2.44137089
148regulation of vasculogenesis (GO:2001212)2.43073403
149peptide catabolic process (GO:0043171)2.41553331
150regulation of epidermal cell differentiation (GO:0045604)2.41160144
151tight junction assembly (GO:0070830)2.40380256
152glandular epithelial cell differentiation (GO:0002067)2.39962957
153ceramide biosynthetic process (GO:0046513)2.39672103
154columnar/cuboidal epithelial cell development (GO:0002066)2.36679006
155positive regulation of Cdc42 GTPase activity (GO:0043089)2.35942985
156regulation of cardioblast differentiation (GO:0051890)2.35902097
157hair cell differentiation (GO:0035315)2.35406079
158cytoskeletal anchoring at plasma membrane (GO:0007016)2.34288449
159* alditol phosphate metabolic process (GO:0052646)2.32985296
160regulation of heart rate by cardiac conduction (GO:0086091)2.32229379
161striated muscle atrophy (GO:0014891)2.32123732
162auditory receptor cell differentiation (GO:0042491)2.31018110
163negative regulation of protein localization to cell surface (GO:2000009)2.26352320
164cardiac conduction (GO:0061337)2.25964920
165negative regulation of complement activation (GO:0045916)2.24742741
166respiratory gaseous exchange (GO:0007585)2.23483253
167cell-substrate junction assembly (GO:0007044)2.22654765
168regulation of p38MAPK cascade (GO:1900744)2.22549422
169desmosome organization (GO:0002934)11.7032396

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KLF2_18264089_ChIP-ChIP_MESCs_Mouse4.11240621
2KLF5_18264089_ChIP-ChIP_MESCs_Mouse4.11240621
3KLF4_18264089_ChIP-ChIP_MESCs_Mouse4.11240621
4TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse4.09190071
5BP1_19119308_ChIP-ChIP_Hs578T_Human3.85187595
6ESR1_20079471_ChIP-ChIP_T-47D_Human2.78819409
7* P63_26484246_Chip-Seq_KERATINOCYTES_Human2.53417685
8STAT6_21828071_ChIP-Seq_BEAS2B_Human2.49639873
9ZNF217_24962896_ChIP-Seq_MCF-7_Human2.28952311
10ZNF263_19887448_ChIP-Seq_K562_Human2.15734754
11TP63_17297297_ChIP-ChIP_HaCaT_Human13.9003844
12FOXO3_23340844_ChIP-Seq_DLD1_Human1.99210385
13AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.95077983
14NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.91875564
15SOX9_24532713_ChIP-Seq_HFSC_Mouse1.89897792
16FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.89086791
17HIF1A_21447827_ChIP-Seq_MCF-7_Human1.88777403
18ESR2_21235772_ChIP-Seq_MCF-7_Human1.86645145
19ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.80161404
20TCF3_18692474_ChIP-Seq_MEFs_Mouse1.79562544
21ESR1_21235772_ChIP-Seq_MCF-7_Human1.75997990
22TCF3_18692474_ChIP-Seq_MESCs_Mouse1.66251534
23RARG_19884340_ChIP-ChIP_MEFs_Mouse1.60729812
24STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.58424525
25FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.57826762
26FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.53548443
27KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.52588042
28NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.52517833
29IRF8_22096565_ChIP-ChIP_GC-B_Human1.51592528
30* CDX2_20551321_ChIP-Seq_CACO-2_Human1.51400942
31RXR_22108803_ChIP-Seq_LS180_Human1.48170874
32SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.44288280
33SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.44288280
34TCF4_18268006_ChIP-ChIP_LS174T_Human1.44049651
35LXR_22158963_ChIP-Seq_LIVER_Mouse1.43163261
36RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.41812906
37RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.41698369
38PPARA_22158963_ChIP-Seq_LIVER_Mouse1.40084296
39SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.38216371
40PPAR_26484153_Chip-Seq_NCI-H1993_Human1.36543190
41RACK7_27058665_Chip-Seq_MCF-7_Human1.35577308
42CDX2_19796622_ChIP-Seq_MESCs_Mouse1.34047823
43* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.32741842
44FOXA1_25552417_ChIP-Seq_VCAP_Human1.32038323
45NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.30254694
46PIAS1_25552417_ChIP-Seq_VCAP_Human1.29813738
47SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.29687474
48STAT3_1855785_ChIP-Seq_MESCs_Mouse1.29335104
49BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.27703994
50TP63_22573176_ChIP-Seq_HFKS_Human1.27416254
51TBX20_22328084_ChIP-Seq_HEART_Mouse1.26343764
52TBX20_22080862_ChIP-Seq_HEART_Mouse1.26343764
53AR_21572438_ChIP-Seq_LNCaP_Human1.25588913
54TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.25514686
55RXR_22158963_ChIP-Seq_LIVER_Mouse1.24885880
56RUNX1_27514584_Chip-Seq_MCF-7_Human1.23584053
57SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.22971958
58ARNT_22903824_ChIP-Seq_MCF-7_Human1.22933268
59CLOCK_20551151_ChIP-Seq_293T_Human1.21137528
60NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.20979409
61KLF5_25053715_ChIP-Seq_YYC3_Human1.20335879
62FOXM1_26456572_ChIP-Seq_MCF-7_Human1.19836101
63PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.19237187
64SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.19114747
65AR_21909140_ChIP-Seq_LNCAP_Human1.18176967
66POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.17920870
67GATA6_25053715_ChIP-Seq_YYC3_Human1.17610637
68KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.16945491
69TP63_19390658_ChIP-ChIP_HaCaT_Human1.16917778
70KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.15736787
71NANOG_18692474_ChIP-Seq_MEFs_Mouse1.14088745
72SRY_22984422_ChIP-ChIP_TESTIS_Rat1.12780835
73NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.12048055
74* CREB1_26743006_Chip-Seq_LNCaP_Human1.11848878
75GATA4_25053715_ChIP-Seq_YYC3_Human1.09226573
76TCF7_22412390_ChIP-Seq_EML_Mouse1.08931997
77ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.08636379
78TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.08482019
79* CTCF_27219007_Chip-Seq_Bcells_Human1.07362275
80TRIM28_21343339_ChIP-Seq_HEK293_Human1.06786285
81EGR1_19032775_ChIP-ChIP_M12_Human1.06326745
82ATF3_27146783_Chip-Seq_COLON_Human1.05973177
83IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.04342831
84NANOG_18692474_ChIP-Seq_MESCs_Mouse1.04337145
85PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.04068155
86ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.01943490
87GATA2_21666600_ChIP-Seq_HMVEC_Human1.01866677
88ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.01236192
89SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.99300142
90TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.98213070
91CHD1_26751641_Chip-Seq_LNCaP_Human0.98152678
92SOX2_20726797_ChIP-Seq_SW620_Human0.97548645
93* GATA3_24758297_ChIP-Seq_MCF-7_Human0.97213747
94BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.96423016
95STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.94935093
96TP63_23658742_ChIP-Seq_EP156T_Human0.94770876
97* LXR_22292898_ChIP-Seq_THP-1_Human0.94452445
98YY1_22570637_ChIP-Seq_MALME-3M_Human0.94055963
99ELK3_25401928_ChIP-Seq_HUVEC_Human0.93786851
100NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.93386607
101TP53_20018659_ChIP-ChIP_R1E_Mouse0.92089781
102GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.91833908
103KDM2B_26808549_Chip-Seq_SUP-B15_Human0.91774046
104CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.90515159
105BCOR_27268052_Chip-Seq_Bcells_Human0.90334981
106KDM2B_26808549_Chip-Seq_K562_Human0.90184602
107FOXA2_19822575_ChIP-Seq_HepG2_Human0.89650808
108SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.85743062
109FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.85695907
110CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.85501558
111GATA2_19941826_ChIP-Seq_K562_Human0.85222606
112P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.82992586
113ERG_21242973_ChIP-ChIP_JURKAT_Human0.82725009
114NOTCH1_21737748_ChIP-Seq_TLL_Human0.82440658
115PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.81334928
116CJUN_26792858_Chip-Seq_BT549_Human0.80444601
117GATA1_19941826_ChIP-Seq_K562_Human0.80107926
118TP53_22127205_ChIP-Seq_IMR90_Human0.78999448
119STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.78992649
120THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.78879692
121CTNNB1_20460455_ChIP-Seq_HCT116_Human0.78499239
122OCT4_18692474_ChIP-Seq_MEFs_Mouse0.78348080
123SA1_27219007_Chip-Seq_Bcells_Human0.77339214
124PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.77250029
125EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.76401279
126GATA1_22025678_ChIP-Seq_K562_Human0.76155862
127SMAD3_21741376_ChIP-Seq_HESCs_Human0.75566751
128NFIB_24661679_ChIP-Seq_LUNG_Mouse0.75403498
129TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.75359612
130UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.75020727
131WT1_25993318_ChIP-Seq_PODOCYTE_Human0.74539677
132P68_20966046_ChIP-Seq_HELA_Human0.73986968
133CEBPB_22108803_ChIP-Seq_LS180_Human0.73768186
134AHR_22903824_ChIP-Seq_MCF-7_Human0.73236136
135* CSB_26484114_Chip-Seq_FIBROBLAST_Human0.71632438
136FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.71329006
137SMC4_20622854_ChIP-Seq_HELA_Human0.71298323
138* UBF1/2_26484160_Chip-Seq_HMECs_Human0.71135439
139SOX2_27498859_Chip-Seq_STOMACH_Mouse0.71126881
140FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.71070596
141NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.71067473
142CTCF_27219007_Chip-Seq_ERYTHROID_Human0.70952276
143TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.69936176
144SA1_27219007_Chip-Seq_ERYTHROID_Human0.69544202
145CTCF_21964334_Chip-Seq_Bcells_Human0.69442829
146POU5F1_16518401_ChIP-PET_MESCs_Mouse0.68871526
147IRF8_21731497_ChIP-ChIP_J774_Mouse0.68365547
148POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.67867031
149SOX2_18692474_ChIP-Seq_MEFs_Mouse0.66723921
150ELF1_20517297_ChIP-Seq_JURKAT_Human0.65806717
151ZFP281_27345836_Chip-Seq_ESCs_Mouse0.65641056

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002796_impaired_skin_barrier6.49465716
2MP0002254_reproductive_system_inflammat6.13023432
3MP0005275_abnormal_skin_tensile4.07484639
4MP0010234_abnormal_vibrissa_follicle4.03777403
5MP0004381_abnormal_hair_follicle3.84139021
6MP0005501_abnormal_skin_physiology3.76782157
7MP0003941_abnormal_skin_development3.31909154
8MP0000383_abnormal_hair_follicle3.18870944
9MP0001216_abnormal_epidermal_layer3.10464647
10MP0003453_abnormal_keratinocyte_physiol2.95805809
11MP0003011_delayed_dark_adaptation2.94600558
12MP0010678_abnormal_skin_adnexa2.82406891
13MP0003705_abnormal_hypodermis_morpholog2.79402907
14MP0002060_abnormal_skin_morphology2.71784479
15MP0002098_abnormal_vibrissa_morphology2.65058984
16MP0004947_skin_inflammation2.55157427
17MP0000579_abnormal_nail_morphology2.54429279
18MP0000647_abnormal_sebaceous_gland2.50797235
19MP0010771_integument_phenotype2.28926876
20MP0000377_abnormal_hair_follicle2.20653581
21MP0005075_abnormal_melanosome_morpholog2.04066905
22MP0010352_gastrointestinal_tract_polyps2.02933297
23MP0004264_abnormal_extraembryonic_tissu2.01987112
24MP0002277_abnormal_respiratory_mucosa1.96124640
25MP0001958_emphysema1.94389788
26MP0005409_darkened_coat_color1.90910289
27MP0001188_hyperpigmentation1.90120163
28MP0000762_abnormal_tongue_morphology1.76641971
29MP0000467_abnormal_esophagus_morphology1.74019209
30MP0002009_preneoplasia1.73143171
31MP0004782_abnormal_surfactant_physiolog1.72178056
32MP0009780_abnormal_chondrocyte_physiolo1.69051716
33MP0001346_abnormal_lacrimal_gland1.61650077
34MP0000427_abnormal_hair_cycle1.61186899
35MP0004185_abnormal_adipocyte_glucose1.60015386
36MP0003566_abnormal_cell_adhesion1.55621922
37MP0001243_abnormal_dermal_layer1.55097467
38MP0009931_abnormal_skin_appearance1.49239201
39MP0004858_abnormal_nervous_system1.43478466
40MP0002877_abnormal_melanocyte_morpholog1.42113722
41MP0000367_abnormal_coat/_hair1.39745667
42MP0001191_abnormal_skin_condition1.35625831
43MP0003436_decreased_susceptibility_to1.29345598
44MP0001348_abnormal_lacrimal_gland1.28902431
45MP0008995_early_reproductive_senescence1.26041188
46MP0005451_abnormal_body_composition1.21667055
47MP0002006_tumorigenesis1.18280236
48MP0000566_synostosis1.17386237
49MP0002332_abnormal_exercise_endurance1.15819244
50MP0003890_abnormal_embryonic-extraembry1.13302470
51MP0002095_abnormal_skin_pigmentation1.12070268
52MP0005023_abnormal_wound_healing1.11714966
53MP0005257_abnormal_intraocular_pressure1.09987674
54MP0003183_abnormal_peptide_metabolism1.08898099
55MP0002166_altered_tumor_susceptibility1.08284929
56MP0003878_abnormal_ear_physiology1.06897014
57MP0005377_hearing/vestibular/ear_phenot1.06897014
58MP0000015_abnormal_ear_pigmentation1.06142082
59MP0008057_abnormal_DNA_replication1.03048382
60MP0005394_taste/olfaction_phenotype1.02099120
61MP0005499_abnormal_olfactory_system1.02099120
62MP0002148_abnormal_hypersensitivity_rea0.98565621
63MP0004043_abnormal_pH_regulation0.96870238
64MP0003938_abnormal_ear_development0.95971460
65MP0008961_abnormal_basal_metabolism0.95249671
66MP0000465_gastrointestinal_hemorrhage0.93561389
67MP0000627_abnormal_mammary_gland0.92658071
68MP0008004_abnormal_stomach_pH0.92537335
69MP0006138_congestive_heart_failure0.91381686
70MP0005174_abnormal_tail_pigmentation0.90139024
71MP0005647_abnormal_sex_gland0.89915998
72MP0001835_abnormal_antigen_presentation0.87030462
73MP0003191_abnormal_cellular_cholesterol0.86107427
74MP0002133_abnormal_respiratory_system0.86052005
75MP0005388_respiratory_system_phenotype0.86052005
76MP0001849_ear_inflammation0.84934232
77MP0000685_abnormal_immune_system0.84633638
78MP0001851_eye_inflammation0.84416636
79MP0005076_abnormal_cell_differentiation0.80546130
80MP0004957_abnormal_blastocyst_morpholog0.79094006
81MP0003763_abnormal_thymus_physiology0.75754676
82MP0000462_abnormal_digestive_system0.74598837
83MP0002138_abnormal_hepatobiliary_system0.74546002
84MP0006082_CNS_inflammation0.73858518
85MP0005360_urolithiasis0.72906904
86MP0001790_abnormal_immune_system0.71805573
87MP0005387_immune_system_phenotype0.71805573
88MP0001765_abnormal_ion_homeostasis0.71227904
89MP0000678_abnormal_parathyroid_gland0.71212799
90MP0001666_abnormal_nutrient_absorption0.70355153
91MP0001756_abnormal_urination0.70264241
92MP0005000_abnormal_immune_tolerance0.69326594
93MP0001800_abnormal_humoral_immune0.69034837
94MP0010030_abnormal_orbit_morphology0.65245431
95MP0006292_abnormal_olfactory_placode0.64292220
96MP0005083_abnormal_biliary_tract0.63476060
97MP0003448_altered_tumor_morphology0.63283014
98MP0005666_abnormal_adipose_tissue0.62901823
99MP0001664_abnormal_digestion0.61884433
100MP0004885_abnormal_endolymph0.61303538
101MP0003950_abnormal_plasma_membrane0.60614549
102MP0005025_abnormal_response_to0.60372082
103MP0003315_abnormal_perineum_morphology0.59487018
104MP0010155_abnormal_intestine_physiology0.59436865
105MP0001340_abnormal_eyelid_morphology0.58380962
106MP0003638_abnormal_response/metabolism_0.58035409
107MP0009840_abnormal_foam_cell0.57851036
108MP0003136_yellow_coat_color0.57184368
109MP0005085_abnormal_gallbladder_physiolo0.56749101
110MP0002132_abnormal_respiratory_system0.55338829
111MP0003045_fibrosis0.54366141
112MP0004019_abnormal_vitamin_homeostasis0.52346515
113MP0005248_abnormal_Harderian_gland0.51664486
114MP0000858_altered_metastatic_potential0.49519841
115MP0003755_abnormal_palate_morphology0.48942013
116MP0002163_abnormal_gland_morphology0.48831561
117MP0002723_abnormal_immune_serum0.48689610
118MP0009379_abnormal_foot_pigmentation0.48336259
119MP0001853_heart_inflammation0.48274142
120MP0005670_abnormal_white_adipose0.47810538
121MP0001177_atelectasis0.47572899
122MP0000432_abnormal_head_morphology0.47143119
123MP0001784_abnormal_fluid_regulation0.47052933
124MP0005671_abnormal_response_to0.46142778
125MP0005310_abnormal_salivary_gland0.45734989
126MP0002092_abnormal_eye_morphology0.45393761
127MP0005508_abnormal_skeleton_morphology0.44934944
128MP0009785_altered_susceptibility_to0.44219259
129MP0000490_abnormal_crypts_of0.43544451
130MP0009643_abnormal_urine_homeostasis0.43360589
131MP0002452_abnormal_antigen_presenting0.43309996
132MP0000537_abnormal_urethra_morphology0.43180032
133MP0000613_abnormal_salivary_gland0.42160066
134MP0001819_abnormal_immune_cell0.41983354
135MP0002234_abnormal_pharynx_morphology0.41673923
136MP0001873_stomach_inflammation0.41175499
137MP0000470_abnormal_stomach_morphology0.40654809
138MP0003091_abnormal_cell_migration0.37984372
139MP0002118_abnormal_lipid_homeostasis0.37846736
140MP0005595_abnormal_vascular_smooth0.35700019
141MP0005365_abnormal_bile_salt0.33752182
142MP0002111_abnormal_tail_morphology0.33074260
143MP0004233_abnormal_muscle_weight0.31467801
144MP0001542_abnormal_bone_strength0.30714557
145MP0003879_abnormal_hair_cell0.30606259
146MP0002136_abnormal_kidney_physiology0.29846745
147MP0005375_adipose_tissue_phenotype0.29568897
148MP0002177_abnormal_outer_ear0.29461010
149MP0000477_abnormal_intestine_morphology0.28598487
150MP0005636_abnormal_mineral_homeostasis0.27842300

Predicted human phenotypes

RankGene SetZ-score
1Hypotrichosis (HP:0001006)6.55563645
2Abnormality of nail color (HP:0100643)5.65702504
3Increased IgE level (HP:0003212)5.37959703
4Interstitial pulmonary disease (HP:0006530)5.18958789
5Congenital ichthyosiform erythroderma (HP:0007431)5.18828875
6Plantar hyperkeratosis (HP:0007556)4.99824122
7Palmoplantar hyperkeratosis (HP:0000972)4.78652818
8Woolly hair (HP:0002224)4.74032181
9Right ventricular cardiomyopathy (HP:0011663)4.53657145
10Palmar hyperkeratosis (HP:0010765)4.46866000
11Lip pit (HP:0100267)4.44769237
12Congenital nonbullous ichthyosiform erythroderma (HP:0007479)4.38888200
13Erythroderma (HP:0001019)4.37518004
14Erythema (HP:0010783)4.35610928
15Parakeratosis (HP:0001036)4.04472716
16Bilateral microphthalmos (HP:0007633)3.98678043
17Onycholysis (HP:0001806)3.95646383
18Fragile nails (HP:0001808)3.91390658
19Pili torti (HP:0003777)3.58956542
20Eczematoid dermatitis (HP:0000976)3.51067715
21Abnormality of the salivary glands (HP:0010286)3.49294925
22Thick nail (HP:0001805)3.48048698
23Curly hair (HP:0002212)3.46627077
24Hyperactive renin-angiotensin system (HP:0000841)3.38512706
25Sparse eyelashes (HP:0000653)3.37815268
26Milia (HP:0001056)3.36599937
27Conjunctival hamartoma (HP:0100780)3.27989041
28Multiple enchondromatosis (HP:0005701)3.27982908
29Ventricular tachycardia (HP:0004756)3.24185442
30Abnormal blistering of the skin (HP:0008066)3.12554982
31Nail dystrophy (HP:0008404)3.07879691
32Trismus (HP:0000211)3.07350863
33Partial duplication of thumb phalanx (HP:0009944)3.04908103
34Abnormality of secondary sexual hair (HP:0009888)3.03932960
35Abnormality of the axillary hair (HP:0100134)3.03932960
36Concave nail (HP:0001598)3.01699410
37Hypochromic microcytic anemia (HP:0004840)2.90928507
38Nasal polyposis (HP:0100582)2.89410611
39Absent eyelashes (HP:0000561)2.87522752
40Abnormal hemoglobin (HP:0011902)2.85213425
41Hamartoma of the eye (HP:0010568)2.83783818
42Oral leukoplakia (HP:0002745)2.82281842
43Gangrene (HP:0100758)2.79579337
44Hypohidrosis (HP:0000966)2.72094472
45Natal tooth (HP:0000695)2.68722388
46Abnormality of small intestinal villus morphology (HP:0011472)2.67194327
47Villous atrophy (HP:0011473)2.67194327
48Corneal erosion (HP:0200020)2.67159990
49Increased connective tissue (HP:0009025)2.65243684
50Partial duplication of the phalanx of hand (HP:0009999)2.62668602
51Abnormality of the fingertips (HP:0001211)2.61988534
52Ectropion (HP:0000656)2.59040845
53Rib fusion (HP:0000902)2.53849055
54Sparse scalp hair (HP:0002209)2.52380220
55Distal lower limb muscle weakness (HP:0009053)2.51327857
56Amelogenesis imperfecta (HP:0000705)2.47116853
57Abnormality of permanent molar morphology (HP:0011071)2.46437329
58Abnormality of the dental root (HP:0006486)2.46437329
59Taurodontia (HP:0000679)2.46437329
60Decreased circulating renin level (HP:0003351)2.43139043
61Septate vagina (HP:0001153)2.41080339
62Absent hair (HP:0002298)2.36928703
63Abnormality of the nasal mucosa (HP:0000433)2.33760323
64Abnormality of the dental pulp (HP:0006479)2.33162594
65Abnormality of the distal phalanges of the toes (HP:0010182)2.32843510
66Peritonitis (HP:0002586)2.31962414
67Advanced eruption of teeth (HP:0006288)2.31538167
68Skin pits (HP:0100276)2.31413019
69Hypergammaglobulinemia (HP:0010702)2.28254798
70Hyperkalemia (HP:0002153)2.27916742
71Abnormality of molar (HP:0011077)2.26993040
72Abnormality of molar morphology (HP:0011070)2.26993040
73Hypochromic anemia (HP:0001931)2.26049379
74Hyporeflexia of lower limbs (HP:0002600)2.26007297
75Pruritus (HP:0000989)2.22495927
76Hepatoblastoma (HP:0002884)2.19297875
77Depressed nasal tip (HP:0000437)2.19250399
78Nasolacrimal duct obstruction (HP:0000579)2.18991423
79Palmoplantar keratoderma (HP:0000982)2.18784718
80Testicular atrophy (HP:0000029)2.18608297
81Dehydration (HP:0001944)2.17396853
82Alopecia of scalp (HP:0002293)2.16907810
83Fused cervical vertebrae (HP:0002949)2.15997077
84Cheilitis (HP:0100825)2.14517111
85Achilles tendon contracture (HP:0001771)2.13776066
86Duplicated collecting system (HP:0000081)2.11197865
87Abnormal hair laboratory examination (HP:0003328)2.11006757
88Sensory axonal neuropathy (HP:0003390)2.07225253
89Acanthosis nigricans (HP:0000956)2.06789235
90Blepharitis (HP:0000498)2.06611120
91Anomalous pulmonary venous return (HP:0010772)2.06554154
92Elevated erythrocyte sedimentation rate (HP:0003565)2.06406794
93Seborrheic dermatitis (HP:0001051)2.04197667
94Hypoplastic labia majora (HP:0000059)2.04063542
95Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.04057077
96Pustule (HP:0200039)1.99121229
97Neonatal death (HP:0003811)1.97878568
98Fasciculations (HP:0002380)1.94999781
99Slow-growing hair (HP:0002217)1.94692705
100Abnormality of hair growth rate (HP:0011363)1.94692705
101Abnormality of the Achilles tendon (HP:0005109)1.94465570
102Abnormality of renin-angiotensin system (HP:0000847)1.92855384
103Laryngomalacia (HP:0001601)1.92056321
104Hamartoma (HP:0010566)1.91342571
105Tachypnea (HP:0002789)1.90819512
106Abnormal cartilage morphology (HP:0002763)1.90446807
107Melanocytic nevus (HP:0000995)1.90298866
108Neoplasm of striated muscle (HP:0009728)1.89974049
109Ridged nail (HP:0001807)1.89957991
110Anhidrosis (HP:0000970)1.88738718
111Premature loss of primary teeth (HP:0006323)1.87973807
112Abnormality of the musculature of the hand (HP:0001421)1.87694541
113Popliteal pterygium (HP:0009756)1.87272482
114Abnormality of the lower motor neuron (HP:0002366)1.87178269
115Mildly elevated creatine phosphokinase (HP:0008180)1.86557151
116Difficulty running (HP:0009046)1.86114609
117Aplasia involving bones of the upper limbs (HP:0009823)1.85371317
118Aplasia of the phalanges of the hand (HP:0009802)1.85371317
119Aplasia involving bones of the extremities (HP:0009825)1.85371317
120Abnormality of the renal collecting system (HP:0004742)1.84823981
121Premature ovarian failure (HP:0008209)1.84430052
122Tubulointerstitial fibrosis (HP:0005576)1.84177570
123Multifactorial inheritance (HP:0001426)1.82975939
124Ependymoma (HP:0002888)1.82340743
125Germ cell neoplasia (HP:0100728)1.82287499
126Skin ulcer (HP:0200042)1.81254100
127Abnormality of the labia majora (HP:0012881)1.80828739
128Abnormality of chloride homeostasis (HP:0011422)1.80567449
129Conical tooth (HP:0000698)1.80048510
130Rhabdomyosarcoma (HP:0002859)1.79471313
131Malnutrition (HP:0004395)1.77560799
132Preauricular skin tag (HP:0000384)1.74670409
133Flat acetabular roof (HP:0003180)1.74533281
134Abnormality of the pulmonary veins (HP:0011718)1.71646672
135Absent hand (HP:0004050)1.70984981
136Ventricular fibrillation (HP:0001663)1.70244670
137Myopathic facies (HP:0002058)1.70063400
138Visceral angiomatosis (HP:0100761)1.69953362
139Glossoptosis (HP:0000162)1.69479184
140Abnormality of cells of the erythroid lineage (HP:0012130)1.69088289
141Upper limb muscle weakness (HP:0003484)1.69019063
142Exercise-induced myalgia (HP:0003738)1.68481922
143Xerostomia (HP:0000217)1.64850277
144Split foot (HP:0001839)1.63360006
145Oligodontia (HP:0000677)1.61921170
146Abnormality of sodium homeostasis (HP:0010931)1.60658112
147Furrowed tongue (HP:0000221)1.58446292
148Lack of skin elasticity (HP:0100679)1.56629806
149Abnormality of the gastric mucosa (HP:0004295)1.56347090

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK125.14700122
2MST1R4.48922148
3GRK53.88818339
4ERN13.76768048
5MAP3K63.03183723
6GRK63.03059901
7MST42.98158912
8STK102.72055031
9AKT32.70709968
10GRK12.48695087
11MAPKAPK32.28849247
12ADRBK22.15418472
13MAP3K32.15360697
14TYRO32.15271272
15TGFBR22.13972287
16TGFBR12.13657283
17LMTK22.03848632
18MAP3K142.01571175
19GRK71.92610899
20CSF1R1.82351310
21IKBKB1.78761635
22CAMK1D1.78728621
23FGFR31.76583786
24MOS1.71548637
25MATK1.62802487
26PIM21.59470788
27TYK21.59233469
28PRKD31.58589507
29EPHA21.55784437
30STK241.54280523
31TTK1.53166134
32FGFR11.49153217
33FGFR41.44087188
34MET1.43265048
35RPS6KB21.39634015
36SMG11.39266812
37CAMK1G1.38537813
38ICK1.38388080
39MAP2K61.38015139
40ACVR1B1.37669218
41MAPK71.28897279
42PKN21.26463755
43FER1.22805455
44CHUK1.19178084
45MAP3K21.18657757
46PIK3CA1.15284581
47PRKD21.15136015
48STK391.14821000
49LRRK21.10786180
50ADRBK11.08311744
51TRPM71.06993548
52OBSCN1.02399518
53BLK1.02397057
54IRAK10.98455595
55EPHA30.98039461
56SGK2230.97893939
57SGK4940.97893939
58RPS6KA20.97313146
59RIPK10.93028073
60MTOR0.91941133
61PRPF4B0.91134584
62EIF2AK20.91054968
63MAP3K70.90188768
64WNK10.89819475
65SGK20.89331831
66NTRK20.86723002
67PBK0.85538014
68CDC42BPA0.84357234
69FGFR20.82868556
70MAP3K110.81967497
71ITK0.81083038
72PIK3CG0.79976161
73MUSK0.78304800
74MAP2K40.77393046
75PHKG10.76352116
76PHKG20.76352116
77EPHB10.75598555
78HIPK20.75417999
79MARK20.74571278
80TNK20.73811917
81JAK10.73034399
82PDPK10.72876314
83STK38L0.72848633
84MAP3K100.72129759
85SGK30.71930931
86TESK10.71811405
87MAPKAPK20.70655764
88PRKD10.69143780
89JAK30.68618661
90IKBKE0.68307122
91MYLK0.67531135
92TAOK10.66401943
93CSK0.63376569
94MAP3K10.62982186
95MAP3K130.62407266
96PRKG20.61388134
97PRKAA20.60689272
98NME10.60584901
99DYRK1B0.60510064
100JAK20.59066890
101FRK0.58534478
102RPS6KB10.57989163
103RET0.56891758
104PTK60.56215311
105MAPK150.55686587
106PRKCI0.54245582
107NLK0.54020081
108MAPKAPK50.53469175
109TBK10.52557346
110MAP3K90.52557209
111MAP2K20.52129814
112STK30.50685995
113EEF2K0.48653033
114NTRK10.48568338
115MAPK120.48269273
116NEK60.46611045
117PTK20.44979111
118DMPK0.44538420
119MAP2K10.43818544
120CAMK40.43725475
121MAPK110.39443287
122CDK70.38376229
123STK380.37774856
124PDGFRA0.36023216
125IGF1R0.35809269
126SIK10.35453824
127IRAK30.34955981
128TTN0.34193094
129AKT20.33757403
130LATS20.32202477
131RPS6KA40.30913176
132TRIB30.30000387
133PDGFRB0.29733957
134PRKCD0.29439679
135GSK3A0.29388155
136RPS6KC10.28853892
137RPS6KL10.28853892
138MAP3K50.28472460
139EPHB20.28033379
140HCK0.27362884
141ALK0.26859376
142LATS10.26507661
143BMX0.25635797
144CHEK20.25446055
145ERBB20.24355834
146PAK40.24317263
147ABL10.23382606
148SYK0.23193149
149CDK60.22192104
150PKN10.22004680
151LCK0.20797562

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006034.30045190
2Ribosome_Homo sapiens_hsa030103.44630542
3Cyanoamino acid metabolism_Homo sapiens_hsa004602.88478908
4* Arachidonic acid metabolism_Homo sapiens_hsa005902.70306250
5Vitamin B6 metabolism_Homo sapiens_hsa007502.35544085
6Mineral absorption_Homo sapiens_hsa049782.19742877
7Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.12192391
8Sphingolipid metabolism_Homo sapiens_hsa006002.01578485
9NF-kappa B signaling pathway_Homo sapiens_hsa040641.98667170
10Vitamin digestion and absorption_Homo sapiens_hsa049771.92182470
11* Linoleic acid metabolism_Homo sapiens_hsa005911.84420579
12Fructose and mannose metabolism_Homo sapiens_hsa000511.83677625
13* alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.78679179
14RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.75503113
15p53 signaling pathway_Homo sapiens_hsa041151.73403426
16Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.58649458
17Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.58185930
18Renin-angiotensin system_Homo sapiens_hsa046141.56615960
19Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.56147509
20Toxoplasmosis_Homo sapiens_hsa051451.46712020
21Thyroid cancer_Homo sapiens_hsa052161.46047109
22Phenylalanine metabolism_Homo sapiens_hsa003601.45811142
23Retinol metabolism_Homo sapiens_hsa008301.38430635
24Arginine and proline metabolism_Homo sapiens_hsa003301.36378474
25Jak-STAT signaling pathway_Homo sapiens_hsa046301.36189915
26Fat digestion and absorption_Homo sapiens_hsa049751.35748840
27Fatty acid degradation_Homo sapiens_hsa000711.35685960
28Renin secretion_Homo sapiens_hsa049241.34892191
29Arginine biosynthesis_Homo sapiens_hsa002201.32555956
30Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.32415914
31Circadian rhythm_Homo sapiens_hsa047101.31942646
32NOD-like receptor signaling pathway_Homo sapiens_hsa046211.31356987
33Apoptosis_Homo sapiens_hsa042101.30248389
34Intestinal immune network for IgA production_Homo sapiens_hsa046721.29774442
35beta-Alanine metabolism_Homo sapiens_hsa004101.29628972
36* Vascular smooth muscle contraction_Homo sapiens_hsa042701.29140676
37Leishmaniasis_Homo sapiens_hsa051401.28454148
38Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.26941547
39* GnRH signaling pathway_Homo sapiens_hsa049121.26507066
40Acute myeloid leukemia_Homo sapiens_hsa052211.25184099
41PPAR signaling pathway_Homo sapiens_hsa033201.24957757
42Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.24550908
43Chemical carcinogenesis_Homo sapiens_hsa052041.23913842
44Caffeine metabolism_Homo sapiens_hsa002321.21716236
45Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.19899106
46Herpes simplex infection_Homo sapiens_hsa051681.18604552
47Tryptophan metabolism_Homo sapiens_hsa003801.15922390
48Primary immunodeficiency_Homo sapiens_hsa053401.15760846
49MicroRNAs in cancer_Homo sapiens_hsa052061.12778996
50Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.11798716
51Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.11785829
52Allograft rejection_Homo sapiens_hsa053301.11454552
53TNF signaling pathway_Homo sapiens_hsa046681.10788668
54* Glycerophospholipid metabolism_Homo sapiens_hsa005641.10742634
55Nitrogen metabolism_Homo sapiens_hsa009101.10298042
56Hepatitis C_Homo sapiens_hsa051601.09797860
57* Ovarian steroidogenesis_Homo sapiens_hsa049131.09214377
58Staphylococcus aureus infection_Homo sapiens_hsa051501.07559708
59Bile secretion_Homo sapiens_hsa049761.07487923
60Histidine metabolism_Homo sapiens_hsa003401.05727342
61Leukocyte transendothelial migration_Homo sapiens_hsa046701.04802703
62Influenza A_Homo sapiens_hsa051641.03507525
63Pancreatic secretion_Homo sapiens_hsa049721.02068829
64Sphingolipid signaling pathway_Homo sapiens_hsa040711.00697715
65Fatty acid metabolism_Homo sapiens_hsa012121.00223468
66Adherens junction_Homo sapiens_hsa045200.99873888
67T cell receptor signaling pathway_Homo sapiens_hsa046600.99642621
68Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.99292688
69Phototransduction_Homo sapiens_hsa047440.94795945
70Transcriptional misregulation in cancer_Homo sapiens_hsa052020.94606794
71Basal cell carcinoma_Homo sapiens_hsa052170.94517081
72Proteoglycans in cancer_Homo sapiens_hsa052050.93589077
73Notch signaling pathway_Homo sapiens_hsa043300.93542143
74Toll-like receptor signaling pathway_Homo sapiens_hsa046200.92873835
75African trypanosomiasis_Homo sapiens_hsa051430.91602341
76Graft-versus-host disease_Homo sapiens_hsa053320.91172307
77Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.90750830
78Pertussis_Homo sapiens_hsa051330.89199449
79Bladder cancer_Homo sapiens_hsa052190.88473353
80Insulin signaling pathway_Homo sapiens_hsa049100.88100545
81* Ether lipid metabolism_Homo sapiens_hsa005650.87345469
82Sulfur metabolism_Homo sapiens_hsa009200.87329539
83Legionellosis_Homo sapiens_hsa051340.86873875
84Small cell lung cancer_Homo sapiens_hsa052220.85962884
85Adipocytokine signaling pathway_Homo sapiens_hsa049200.84696127
86mTOR signaling pathway_Homo sapiens_hsa041500.84233891
87Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.83553151
88Tight junction_Homo sapiens_hsa045300.83507346
89Amoebiasis_Homo sapiens_hsa051460.82693657
90* Choline metabolism in cancer_Homo sapiens_hsa052310.82320081
91Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.81222637
92Galactose metabolism_Homo sapiens_hsa000520.80858123
93Pentose and glucuronate interconversions_Homo sapiens_hsa000400.80767338
94Fatty acid elongation_Homo sapiens_hsa000620.79670740
95Lysosome_Homo sapiens_hsa041420.77699298
96Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.77569297
97* Serotonergic synapse_Homo sapiens_hsa047260.77340928
98Glucagon signaling pathway_Homo sapiens_hsa049220.77335808
99Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.76498949
100Protein digestion and absorption_Homo sapiens_hsa049740.75626431
101Antigen processing and presentation_Homo sapiens_hsa046120.75420905
102Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.75387051
1032-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.75036937
104ABC transporters_Homo sapiens_hsa020100.74843326
105Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.74137344
106* VEGF signaling pathway_Homo sapiens_hsa043700.73645132
107Hippo signaling pathway_Homo sapiens_hsa043900.73531628
108Aldosterone synthesis and secretion_Homo sapiens_hsa049250.73480899
109Steroid hormone biosynthesis_Homo sapiens_hsa001400.73179567
110Regulation of actin cytoskeleton_Homo sapiens_hsa048100.72865279
111Tyrosine metabolism_Homo sapiens_hsa003500.70029079
112Pathways in cancer_Homo sapiens_hsa052000.68955456
113Fatty acid biosynthesis_Homo sapiens_hsa000610.67046845
114Salivary secretion_Homo sapiens_hsa049700.66635139
115Glycerolipid metabolism_Homo sapiens_hsa005610.65191529
116Measles_Homo sapiens_hsa051620.65023085
117Inositol phosphate metabolism_Homo sapiens_hsa005620.64173389
118Gastric acid secretion_Homo sapiens_hsa049710.62644380
119Tuberculosis_Homo sapiens_hsa051520.62287078
120Primary bile acid biosynthesis_Homo sapiens_hsa001200.61563348
121Osteoclast differentiation_Homo sapiens_hsa043800.61498560
122AMPK signaling pathway_Homo sapiens_hsa041520.61321434
123Starch and sucrose metabolism_Homo sapiens_hsa005000.57863897
124Hedgehog signaling pathway_Homo sapiens_hsa043400.57547672
125Estrogen signaling pathway_Homo sapiens_hsa049150.57308123
126Lysine degradation_Homo sapiens_hsa003100.57183237
127* Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.55852169
128Rap1 signaling pathway_Homo sapiens_hsa040150.54989536
129Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.54934835
130Axon guidance_Homo sapiens_hsa043600.53925320
131Dorso-ventral axis formation_Homo sapiens_hsa043200.53477368
132Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.52725425
133* Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.52146837
134Prolactin signaling pathway_Homo sapiens_hsa049170.51512607
135Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.51482496
136Other glycan degradation_Homo sapiens_hsa005110.50472623
137ECM-receptor interaction_Homo sapiens_hsa045120.50377411
138* Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.49958497
139Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.49731288
140Insulin resistance_Homo sapiens_hsa049310.49339010
141* Ras signaling pathway_Homo sapiens_hsa040140.48810957
142Renal cell carcinoma_Homo sapiens_hsa052110.48708988
143Steroid biosynthesis_Homo sapiens_hsa001000.46448763
144* Platelet activation_Homo sapiens_hsa046110.45738463
145Endocytosis_Homo sapiens_hsa041440.43806325
146AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.43489876
147Pancreatic cancer_Homo sapiens_hsa052120.43264927
148Hematopoietic cell lineage_Homo sapiens_hsa046400.43146175
149Thyroid hormone signaling pathway_Homo sapiens_hsa049190.42961195
150Phosphatidylinositol signaling system_Homo sapiens_hsa040700.42782078
151Malaria_Homo sapiens_hsa051440.41439782
152B cell receptor signaling pathway_Homo sapiens_hsa046620.41410347
153* Long-term depression_Homo sapiens_hsa047300.39347404
154Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.38865759
155* Oxytocin signaling pathway_Homo sapiens_hsa049210.38202610
156Focal adhesion_Homo sapiens_hsa045100.36744535
157cGMP-PKG signaling pathway_Homo sapiens_hsa040220.36217306
158Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.36087687
159Long-term potentiation_Homo sapiens_hsa047200.34712723

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