PLA2G5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the secretory phospholipase A2 family. It is located in a tightly-linked cluster of secretory phospholipase A2 genes on chromosome 1. The encoded enzyme catalyzes the hydrolysis of membrane phospholipids to generate lysophospholipids and free fatty acids including arachidonic acid. It preferentially hydrolyzes linoleoyl-containing phosphatidylcholine substrates. Secretion of this enzyme is thought to induce inflammatory responses in neighboring cells. Alternatively spliced transcript variants have been found, but their full-length nature has not been determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1vitamin A metabolic process (GO:0006776)7.23296658
2sarcomere organization (GO:0045214)6.77773254
3cardiac myofibril assembly (GO:0055003)6.58733514
4negative regulation of potassium ion transmembrane transporter activity (GO:1901017)6.22569921
5tricarboxylic acid cycle (GO:0006099)5.93440534
6protein K11-linked deubiquitination (GO:0035871)5.89467888
7negative regulation of potassium ion transmembrane transport (GO:1901380)5.73602766
8myofibril assembly (GO:0030239)5.59503706
9bundle of His cell to Purkinje myocyte communication (GO:0086069)5.55642671
10detection of chemical stimulus involved in sensory perception of smell (GO:0050911)5.39533710
11regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO5.38363029
12tooth mineralization (GO:0034505)5.33289696
13activation of protein kinase A activity (GO:0034199)5.30433695
14regulation of rhodopsin mediated signaling pathway (GO:0022400)5.26481522
15ventricular cardiac muscle cell action potential (GO:0086005)5.25146703
16positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)5.23663883
17rhodopsin mediated signaling pathway (GO:0016056)5.21413939
18cardiac muscle contraction (GO:0060048)5.12845488
19cardiac muscle cell development (GO:0055013)4.88444791
20regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)4.82712144
21regulation of actin filament-based movement (GO:1903115)4.76136427
22regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)4.69876374
23cAMP biosynthetic process (GO:0006171)4.64060516
24cardiac cell development (GO:0055006)4.59603987
25membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.59597411
26regulation of skeletal muscle contraction (GO:0014819)4.57233502
27thyroid hormone generation (GO:0006590)4.56179172
28plasma membrane repair (GO:0001778)4.54582487
29negative regulation of cytosolic calcium ion concentration (GO:0051481)4.52648827
30regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)4.51615582
31regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)4.46634701
32cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.38620228
33mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.38303163
34receptor guanylyl cyclase signaling pathway (GO:0007168)4.30957595
35regulation of the force of heart contraction (GO:0002026)4.29151117
36cell communication involved in cardiac conduction (GO:0086065)4.25884892
37actomyosin structure organization (GO:0031032)4.24407103
38muscle filament sliding (GO:0030049)4.22399502
39actin-myosin filament sliding (GO:0033275)4.22399502
40ventricular cardiac muscle tissue morphogenesis (GO:0055010)4.14924387
41carnitine shuttle (GO:0006853)4.14109338
42C21-steroid hormone biosynthetic process (GO:0006700)4.11456333
43cardiac muscle tissue morphogenesis (GO:0055008)4.06288424
44regulation of relaxation of muscle (GO:1901077)4.05038797
45ATP synthesis coupled proton transport (GO:0015986)4.03553970
46energy coupled proton transport, down electrochemical gradient (GO:0015985)4.03553970
47heart trabecula formation (GO:0060347)4.03498054
48regulation of acyl-CoA biosynthetic process (GO:0050812)3.94814932
49detection of calcium ion (GO:0005513)3.92662293
50adult heart development (GO:0007512)3.92506670
51righting reflex (GO:0060013)3.87534869
52oxidative phosphorylation (GO:0006119)3.80905336
53regulation of cardioblast differentiation (GO:0051890)3.76107358
54regulation of cardiac muscle cell contraction (GO:0086004)3.76055105
55cell communication by electrical coupling (GO:0010644)3.75057852
56regulation of coenzyme metabolic process (GO:0051196)3.74068875
57regulation of cofactor metabolic process (GO:0051193)3.74068875
58heterotypic cell-cell adhesion (GO:0034113)3.74051111
59seminiferous tubule development (GO:0072520)3.72405494
60phototransduction, visible light (GO:0007603)3.68742467
61phototransduction (GO:0007602)3.67314796
62regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.66717004
63respiratory electron transport chain (GO:0022904)3.66372837
64protein-chromophore linkage (GO:0018298)3.65671555
65NADH metabolic process (GO:0006734)3.65279885
66muscle tissue morphogenesis (GO:0060415)3.65246801
67regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.65023329
68striated muscle contraction (GO:0006941)3.64290153
69relaxation of cardiac muscle (GO:0055119)3.61785661
70regulation of membrane repolarization (GO:0060306)3.59379766
71thyroid hormone metabolic process (GO:0042403)3.59304518
72photoreceptor cell development (GO:0042461)3.58994481
73cardiac muscle hypertrophy (GO:0003300)3.55264066
74electron transport chain (GO:0022900)3.55103713
75mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.53626245
76striated muscle hypertrophy (GO:0014897)3.52240930
77regulation of striated muscle contraction (GO:0006942)3.51175386
78actin-mediated cell contraction (GO:0070252)3.50890554
79response to caffeine (GO:0031000)3.49669030
80cardiac muscle cell action potential involved in contraction (GO:0086002)3.45774130
81cardiac muscle cell action potential (GO:0086001)3.45237381
82regulation of cell communication by electrical coupling (GO:0010649)3.43872890
83retinal cone cell development (GO:0046549)3.43355146
84detection of chemical stimulus involved in sensory perception (GO:0050907)3.41336428
85fatty acid transmembrane transport (GO:1902001)3.40293269
86detection of light stimulus involved in sensory perception (GO:0050962)3.39360440
87detection of light stimulus involved in visual perception (GO:0050908)3.39360440
88positive regulation of heart contraction (GO:0045823)3.38313911
89detection of light stimulus (GO:0009583)3.37398188
90positive regulation of action potential (GO:0045760)3.34808188
91photoreceptor cell maintenance (GO:0045494)3.34017509
92heart contraction (GO:0060047)3.32029333
93heart process (GO:0003015)3.32029333
94carnitine transmembrane transport (GO:1902603)3.29048840
95detection of visible light (GO:0009584)3.28824004
96regulation of heart rate (GO:0002027)3.28246689
97eye photoreceptor cell development (GO:0042462)3.27717373
98negative regulation of T-helper cell differentiation (GO:0045623)3.27425560
99negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.27425560
100regulation of sarcomere organization (GO:0060297)3.25537195
101positive regulation of protein sumoylation (GO:0033235)3.22265677
102positive regulation of heart rate (GO:0010460)3.22212302
103gonadal mesoderm development (GO:0007506)3.22135032
104carnitine transport (GO:0015879)3.17089207
105amino-acid betaine transport (GO:0015838)3.17089207
106positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.16660493
107retinal rod cell development (GO:0046548)3.15605881
108dendritic spine morphogenesis (GO:0060997)3.13134833
109regulation of heart rate by cardiac conduction (GO:0086091)3.12995520
110photoreceptor cell differentiation (GO:0046530)3.12589237
111eye photoreceptor cell differentiation (GO:0001754)3.12589237
1122-oxoglutarate metabolic process (GO:0006103)3.10072404
113neuronal ion channel clustering (GO:0045161)3.09613245
114desmosome organization (GO:0002934)3.09400738
115regulation of cardiac muscle contraction (GO:0055117)3.09233807
116ketone biosynthetic process (GO:0042181)3.09112478
117regulation of guanylate cyclase activity (GO:0031282)3.09095784
118cardiac conduction (GO:0061337)3.06756224
119muscle hypertrophy (GO:0014896)3.06531751
120visual perception (GO:0007601)3.06529310
121cAMP metabolic process (GO:0046058)3.04362396
122positive regulation of mitochondrial fission (GO:0090141)3.02649828
123cyclic nucleotide biosynthetic process (GO:0009190)3.01018088
124cyclic purine nucleotide metabolic process (GO:0052652)3.00781288
125regulation of cilium movement (GO:0003352)2.99847071
126nephron epithelium morphogenesis (GO:0072088)2.97386446
127nephron tubule morphogenesis (GO:0072078)2.97386446
128regulation of heart contraction (GO:0008016)2.97018896
129reflex (GO:0060004)2.92987293
130short-term memory (GO:0007614)2.92772717
131negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.89179613
132adrenergic receptor signaling pathway (GO:0071875)2.84132762
133detection of chemical stimulus (GO:0009593)2.83127682
134response to epinephrine (GO:0071871)2.82905487
135neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.76188207
136positive regulation of sodium ion transport (GO:0010765)2.73635522
137regulation of protein glycosylation (GO:0060049)2.73092464
138negative regulation of calcium ion transmembrane transport (GO:1903170)2.72771309
139negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.72771309
140enteric nervous system development (GO:0048484)2.72024018
141regulation of lipoprotein metabolic process (GO:0050746)2.71981257
142negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.69303253
143regulation of action potential (GO:0098900)2.68681074
144cardiac chamber formation (GO:0003207)2.67158123
145regulation of appetite (GO:0032098)2.66642659
146water transport (GO:0006833)2.65369759
147cardiac muscle adaptation (GO:0014887)2.63721360
148muscle hypertrophy in response to stress (GO:0003299)2.63721360

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.23979576
2EZH2_22144423_ChIP-Seq_EOC_Human4.47155813
3ESRRB_18555785_ChIP-Seq_MESCs_Mouse3.76785470
4EP300_21415370_ChIP-Seq_HL-1_Mouse3.53882745
5HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.45968459
6VDR_22108803_ChIP-Seq_LS180_Human3.39665964
7ZNF263_19887448_ChIP-Seq_K562_Human3.28510918
8TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.27593303
9RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.07963349
10GBX2_23144817_ChIP-Seq_PC3_Human3.07506545
11TBX20_22328084_ChIP-Seq_HEART_Mouse2.99550269
12TBX20_22080862_ChIP-Seq_HEART_Mouse2.99550269
13CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.89787718
14IGF1R_20145208_ChIP-Seq_DFB_Human2.83795774
15AR_21572438_ChIP-Seq_LNCaP_Human2.58421689
16RARG_19884340_ChIP-ChIP_MEFs_Mouse2.57900973
17TP63_17297297_ChIP-ChIP_HaCaT_Human2.51884367
18GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.39982522
19CLOCK_20551151_ChIP-Seq_293T_Human2.39626748
20NR0B1_18358816_ChIP-ChIP_MESCs_Mouse2.26245578
21ESR2_21235772_ChIP-Seq_MCF-7_Human2.16940603
22ZFP57_27257070_Chip-Seq_ESCs_Mouse2.11124663
23SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.02652112
24GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.91094707
25SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.87321393
26TRIM28_21343339_ChIP-Seq_HEK293_Human1.84774867
27PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.83723330
28TP53_16413492_ChIP-PET_HCT116_Human1.77179491
29MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.74518606
30EED_16625203_ChIP-ChIP_MESCs_Mouse1.73661430
31PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.72284806
32ESR1_20079471_ChIP-ChIP_T-47D_Human1.70227778
33NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.69278966
34HIF1A_21447827_ChIP-Seq_MCF-7_Human1.67802268
35RACK7_27058665_Chip-Seq_MCF-7_Human1.67196619
36CTBP1_25329375_ChIP-Seq_LNCAP_Human1.66857738
37ZNF274_21170338_ChIP-Seq_K562_Hela1.66378311
38SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.66193668
39ATF3_27146783_Chip-Seq_COLON_Human1.65649592
40SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.64498346
41NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.62323000
42EZH2_27304074_Chip-Seq_ESCs_Mouse1.61580555
43LXR_22292898_ChIP-Seq_THP-1_Human1.61573974
44SMAD4_21799915_ChIP-Seq_A2780_Human1.61414305
45CTBP2_25329375_ChIP-Seq_LNCAP_Human1.59876321
46CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.59239666
47* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.59017522
48EZH2_27294783_Chip-Seq_ESCs_Mouse1.57319381
49BCAT_22108803_ChIP-Seq_LS180_Human1.57247584
50DROSHA_22980978_ChIP-Seq_HELA_Human1.55271665
51ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.54911383
52* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.54119341
53JARID2_20075857_ChIP-Seq_MESCs_Mouse1.52699331
54STAT3_1855785_ChIP-Seq_MESCs_Mouse1.52300022
55JARID2_20064375_ChIP-Seq_MESCs_Mouse1.52125028
56TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.52033648
57RUNX1_27514584_Chip-Seq_MCF-7_Human1.51451669
58PCGF2_27294783_Chip-Seq_NPCs_Mouse1.49535057
59POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.49521765
60KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.49471447
61ER_23166858_ChIP-Seq_MCF-7_Human1.48423707
62NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.46550030
63CBX2_27304074_Chip-Seq_ESCs_Mouse1.46316190
64SMAD3_21741376_ChIP-Seq_EPCs_Human1.46283302
65GATA4_21415370_ChIP-Seq_HL-1_Mouse1.45113310
66SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.45012489
67TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.43104649
68P68_20966046_ChIP-Seq_HELA_Human1.42781077
69KDM2B_26808549_Chip-Seq_SUP-B15_Human1.42736735
70MTF2_20144788_ChIP-Seq_MESCs_Mouse1.42514629
71SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.42364426
72PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.42113642
73CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.42104338
74EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.42049639
75SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.41132378
76RNF2_27304074_Chip-Seq_ESCs_Mouse1.39357531
77SUZ12_27294783_Chip-Seq_ESCs_Mouse1.37479907
78UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.37447576
79SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.36840810
80EZH2_18974828_ChIP-Seq_MESCs_Mouse1.35968091
81RNF2_18974828_ChIP-Seq_MESCs_Mouse1.35968091
82CDX2_19796622_ChIP-Seq_MESCs_Mouse1.34682946
83TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.34658983
84RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.34331618
85SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.34053560
86ZFP281_18757296_ChIP-ChIP_E14_Mouse1.33398214
87KDM2B_26808549_Chip-Seq_DND41_Human1.33019433
88TP63_22573176_ChIP-Seq_HFKS_Human1.31602432
89ESR1_21235772_ChIP-Seq_MCF-7_Human1.31172433
90SMAD3_21741376_ChIP-Seq_HESCs_Human1.30308757
91PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.29695811
92CTCF_27219007_Chip-Seq_Bcells_Human1.28578316
93THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.28402829
94EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.27905837
95TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.26829766
96POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.26829766
97ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.24903511
98* STAT3_23295773_ChIP-Seq_U87_Human1.24567582
99EGR1_23403033_ChIP-Seq_LIVER_Mouse1.22885074
100KDM2B_26808549_Chip-Seq_K562_Human1.22555234
101GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.22435815
102FLI1_27457419_Chip-Seq_LIVER_Mouse1.21281914
103NR3C1_21868756_ChIP-Seq_MCF10A_Human1.20659857
104* PIAS1_25552417_ChIP-Seq_VCAP_Human1.20483060
105ELK3_25401928_ChIP-Seq_HUVEC_Human1.20343437
106CREB1_26743006_Chip-Seq_LNCaP_Human1.20217216
107PPARA_22158963_ChIP-Seq_LIVER_Mouse1.19932207
108SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.19097878
109TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.18949590
110* AR_25329375_ChIP-Seq_VCAP_Human1.17344944
111TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.15987972
112P300_19829295_ChIP-Seq_ESCs_Human1.15819008
113MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.15370254
114SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.15107382
115POU3F2_20337985_ChIP-ChIP_501MEL_Human1.14859457
116P300_27058665_Chip-Seq_ZR-75-30cells_Human1.14742572
117TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.14162548
118ISL1_27105846_Chip-Seq_CPCs_Mouse1.13464072
119ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.13343294
120EGR1_19032775_ChIP-ChIP_M12_Human1.13318152
121NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.12897202
122TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.12870402
123TCF4_23295773_ChIP-Seq_U87_Human1.12102366
124SUZ12_27294783_Chip-Seq_NPCs_Mouse1.11408061
125SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.11071228
126REST_21632747_ChIP-Seq_MESCs_Mouse1.10613320
127EZH2_27294783_Chip-Seq_NPCs_Mouse1.10410412
128SMAD4_21741376_ChIP-Seq_EPCs_Human1.09665417
129UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.08980355
130NR3C1_23031785_ChIP-Seq_PC12_Mouse1.08939593
131TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.08827489
132CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.07516200
133TCF4_22108803_ChIP-Seq_LS180_Human1.06947628
134SMC4_20622854_ChIP-Seq_HELA_Human1.06916341
135ERG_21242973_ChIP-ChIP_JURKAT_Human1.06132146
136RNF2_27304074_Chip-Seq_NSC_Mouse1.05742338
137NFE2_27457419_Chip-Seq_LIVER_Mouse1.05209925
138GATA6_25053715_ChIP-Seq_YYC3_Human1.04923025
139PCGF2_27294783_Chip-Seq_ESCs_Mouse1.04257155
140CJUN_26792858_Chip-Seq_BT549_Human1.04245177
141EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.03142765
142KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.02254600
143SOX2_27498859_Chip-Seq_STOMACH_Mouse1.01739538
144BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.01567184
145IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.01397518
146CBP_20019798_ChIP-Seq_JUKART_Human1.01397518
147NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.01099133
148SMAD4_21741376_ChIP-Seq_HESCs_Human1.00602810
149BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.00483826
150PPAR_26484153_Chip-Seq_NCI-H1993_Human1.00296467
151NANOG_18692474_ChIP-Seq_MEFs_Mouse0.97834072
152RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.97768197
153FOXO3_23340844_ChIP-Seq_DLD1_Human0.97644355
154IKZF1_21737484_ChIP-ChIP_HCT116_Human0.97534243
155* PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.97337320
156NANOG_18555785_Chip-Seq_ESCs_Mouse0.97098310
157GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.96158115
158RXR_22108803_ChIP-Seq_LS180_Human0.96081958
159KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.95484970
160CTCF_21964334_Chip-Seq_Bcells_Human0.95169592
161SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.95003906
162ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.94366932
163CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.93710485
164TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.93379717
165BCOR_27268052_Chip-Seq_Bcells_Human0.93009993
166TAF15_26573619_Chip-Seq_HEK293_Human0.92993999
167TP53_18474530_ChIP-ChIP_U2OS_Human0.92901768
168LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.91952443
169KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.91759932
170LXR_22158963_ChIP-Seq_LIVER_Mouse0.91385699
171* TBL1_22424771_ChIP-Seq_293T_Human0.90720477
172ETV2_25802403_ChIP-Seq_MESCs_Mouse0.89464924
173SOX9_24532713_ChIP-Seq_HFSC_Mouse0.89412859
174OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.89186953
175EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.88657536
176KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.88599293
177KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.88599293
178KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.88599293
179BCL6_27268052_Chip-Seq_Bcells_Human0.88518377
180RUNX2_22187159_ChIP-Seq_PCA_Human0.88329379
181GATA3_24758297_ChIP-Seq_MCF-7_Human0.88315275
182OCT4_19829295_ChIP-Seq_ESCs_Human0.88284419
183SA1_27219007_Chip-Seq_ERYTHROID_Human0.87501329
184E2F1_20622854_ChIP-Seq_HELA_Human0.86671067
185SA1_27219007_Chip-Seq_Bcells_Human0.86339497
186FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.86314154
187RXR_22158963_ChIP-Seq_LIVER_Mouse0.85912149
188ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.85698504
189DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.84873175

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003011_delayed_dark_adaptation6.57612509
2MP0004084_abnormal_cardiac_muscle5.30733810
3MP0002837_dystrophic_cardiac_calcinosis4.99278119
4MP0003646_muscle_fatigue4.72111541
5MP0000751_myopathy4.04073480
6MP0004215_abnormal_myocardial_fiber3.83186207
7MP0005084_abnormal_gallbladder_morpholo3.61232722
8MP0004036_abnormal_muscle_relaxation3.57406477
9MP0005551_abnormal_eye_electrophysiolog3.39654335
10MP0005330_cardiomyopathy3.09226862
11MP0005253_abnormal_eye_physiology2.72805036
12MP0003950_abnormal_plasma_membrane2.70223750
13MP0000749_muscle_degeneration2.64630553
14MP0002972_abnormal_cardiac_muscle2.60878395
15MP0008775_abnormal_heart_ventricle2.50592974
16MP0001984_abnormal_olfaction2.48783094
17MP0004087_abnormal_muscle_fiber2.43961116
18MP0006072_abnormal_retinal_apoptosis2.39489041
19MP0000750_abnormal_muscle_regeneration2.23323096
20MP0003137_abnormal_impulse_conducting2.21488114
21MP0004484_altered_response_of2.19863881
22MP0001544_abnormal_cardiovascular_syste2.15363148
23MP0005385_cardiovascular_system_phenoty2.15363148
24MP0005620_abnormal_muscle_contractility2.13509553
25MP0010630_abnormal_cardiac_muscle2.11860718
26MP0003221_abnormal_cardiomyocyte_apopto2.05158526
27MP0004130_abnormal_muscle_cell1.98309859
28MP0004233_abnormal_muscle_weight1.93650226
29MP0006138_congestive_heart_failure1.93136333
30MP0004043_abnormal_pH_regulation1.89871121
31MP0002269_muscular_atrophy1.89263989
32MP0005503_abnormal_tendon_morphology1.82204274
33MP0002106_abnormal_muscle_physiology1.78873393
34MP0003705_abnormal_hypodermis_morpholog1.72335877
35MP0005423_abnormal_somatic_nervous1.65182183
36MP0001986_abnormal_taste_sensitivity1.63783821
37MP0002127_abnormal_cardiovascular_syste1.61266772
38MP0004085_abnormal_heartbeat1.61242641
39MP0000747_muscle_weakness1.60748803
40MP0003828_pulmonary_edema1.54286277
41MP0002736_abnormal_nociception_after1.50363534
42MP0001324_abnormal_eye_pigmentation1.47374366
43MP0005369_muscle_phenotype1.43560814
44MP0002090_abnormal_vision1.43070370
45MP0001968_abnormal_touch/_nociception1.41371817
46MP0001486_abnormal_startle_reflex1.35186688
47MP0006276_abnormal_autonomic_nervous1.34314292
48MP0000759_abnormal_skeletal_muscle1.33626338
49MP0002332_abnormal_exercise_endurance1.32693711
50MP0009745_abnormal_behavioral_response1.31123783
51MP0002272_abnormal_nervous_system1.30569084
52MP0002876_abnormal_thyroid_physiology1.29711876
53MP0006036_abnormal_mitochondrial_physio1.28435897
54MP0005666_abnormal_adipose_tissue1.27083793
55MP0005195_abnormal_posterior_eye1.27014527
56MP0002572_abnormal_emotion/affect_behav1.26743809
57MP0003567_abnormal_fetal_cardiomyocyte1.26240368
58MP0003878_abnormal_ear_physiology1.24310055
59MP0005377_hearing/vestibular/ear_phenot1.24310055
60MP0004272_abnormal_basement_membrane1.23565515
61MP0005391_vision/eye_phenotype1.21959904
62MP0003136_yellow_coat_color1.21456873
63MP0005448_abnormal_energy_balance1.18055247
64MP0008875_abnormal_xenobiotic_pharmacok1.17274056
65MP0001905_abnormal_dopamine_level1.16757850
66MP0001501_abnormal_sleep_pattern1.16685362
67MP0002933_joint_inflammation1.16428258
68MP0001529_abnormal_vocalization1.16164611
69MP0004145_abnormal_muscle_electrophysio1.13966133
70MP0002234_abnormal_pharynx_morphology1.10824370
71MP0003880_abnormal_central_pattern1.08482718
72MP0001970_abnormal_pain_threshold1.06190651
73MP0005595_abnormal_vascular_smooth1.04418861
74MP0005167_abnormal_blood-brain_barrier1.01761438
75MP0002909_abnormal_adrenal_gland1.00942168
76MP0004185_abnormal_adipocyte_glucose0.99748088
77MP0002734_abnormal_mechanical_nocicepti0.97749640
78MP0003252_abnormal_bile_duct0.97040721
79MP0004019_abnormal_vitamin_homeostasis0.96403961
80MP0005623_abnormal_meninges_morphology0.96327166
81MP0000266_abnormal_heart_morphology0.94838195
82MP0000343_altered_response_to0.94716314
83MP0002064_seizures0.94705127
84MP0003329_amyloid_beta_deposits0.94542285
85MP0001879_abnormal_lymphatic_vessel0.92225244
86MP0005165_increased_susceptibility_to0.91695637
87MP0003566_abnormal_cell_adhesion0.90839344
88MP0009046_muscle_twitch0.90586968
89MP0001485_abnormal_pinna_reflex0.87904722
90MP0005375_adipose_tissue_phenotype0.87458024
91MP0002638_abnormal_pupillary_reflex0.85897649
92MP0004510_myositis0.84743877
93MP0005187_abnormal_penis_morphology0.83004919
94MP0003635_abnormal_synaptic_transmissio0.82530489
95MP0005670_abnormal_white_adipose0.81762594
96MP0008004_abnormal_stomach_pH0.81071007
97MP0002063_abnormal_learning/memory/cond0.80733796
98MP0006035_abnormal_mitochondrial_morpho0.80100340
99MP0001958_emphysema0.79235706
100MP0000230_abnormal_systemic_arterial0.78965806
101MP0004924_abnormal_behavior0.76527436
102MP0005386_behavior/neurological_phenoty0.76527436
103MP0005646_abnormal_pituitary_gland0.76104251
104MP0008569_lethality_at_weaning0.75237949
105MP0002229_neurodegeneration0.74856536
106MP0008438_abnormal_cutaneous_collagen0.73134106
107MP0002108_abnormal_muscle_morphology0.72767513
108MP0004133_heterotaxia0.72623880
109MP0001440_abnormal_grooming_behavior0.70005256
110MP0001502_abnormal_circadian_rhythm0.69261588
111MP0002735_abnormal_chemical_nociception0.67575848
112MP0002254_reproductive_system_inflammat0.65535939
113MP0009764_decreased_sensitivity_to0.63257829
114MP0002928_abnormal_bile_duct0.63124696
115MP0002751_abnormal_autonomic_nervous0.62144210
116MP0005332_abnormal_amino_acid0.61800140
117MP0005319_abnormal_enzyme/_coenzyme0.60677036
118MP0005266_abnormal_metabolism0.60114379
119MP0001270_distended_abdomen0.59769805
120MP0002653_abnormal_ependyma_morphology0.59319656
121MP0000383_abnormal_hair_follicle0.58971115
122MP0000003_abnormal_adipose_tissue0.58066414
123MP0005257_abnormal_intraocular_pressure0.57603247
124MP0002128_abnormal_blood_circulation0.57272282
125MP0003195_calcinosis0.56325745
126MP0003984_embryonic_growth_retardation0.53605356
127MP0003879_abnormal_hair_cell0.53528587
128MP0005275_abnormal_skin_tensile0.52389119
129MP0002088_abnormal_embryonic_growth/wei0.51715434
130MP0003279_aneurysm0.51310370
131MP0010678_abnormal_skin_adnexa0.49620734
132MP0009840_abnormal_foam_cell0.49204165
133MP0010368_abnormal_lymphatic_system0.47403343
134MP0003283_abnormal_digestive_organ0.47231005
135MP0002925_abnormal_cardiovascular_devel0.44693923
136MP0002295_abnormal_pulmonary_circulatio0.43442988
137MP0000733_abnormal_muscle_development0.42782766
138MP0001765_abnormal_ion_homeostasis0.40729738
139MP0008961_abnormal_basal_metabolism0.40427012
140MP0001756_abnormal_urination0.39362234
141MP0004885_abnormal_endolymph0.39200711
142MP0002896_abnormal_bone_mineralization0.39025733
143MP0009384_cardiac_valve_regurgitation0.36911678
144MP0010234_abnormal_vibrissa_follicle0.36587912
145MP0001614_abnormal_blood_vessel0.36579429
146MP0005380_embryogenesis_phenotype0.36398740
147MP0001672_abnormal_embryogenesis/_devel0.36398740
148MP0002752_abnormal_somatic_nervous0.35734181
149MP0003941_abnormal_skin_development0.35188019
150MP0000013_abnormal_adipose_tissue0.34373182

Predicted human phenotypes

RankGene SetZ-score
1Congenital stationary night blindness (HP:0007642)6.07609050
2Sudden death (HP:0001699)5.84735246
3Ventricular tachycardia (HP:0004756)5.53624844
4Bony spicule pigmentary retinopathy (HP:0007737)5.47786834
5Central scotoma (HP:0000603)5.06862233
6Scotoma (HP:0000575)4.84234985
7Exercise-induced muscle cramps (HP:0003710)4.83556806
8Muscle fiber splitting (HP:0003555)4.76648171
9Atrial fibrillation (HP:0005110)4.74221346
10Right ventricular cardiomyopathy (HP:0011663)4.65210891
11Chorioretinal atrophy (HP:0000533)4.54726449
12Attenuation of retinal blood vessels (HP:0007843)4.53787980
13Calf muscle hypertrophy (HP:0008981)4.50894730
14Decreased electroretinogram (ERG) amplitude (HP:0000654)4.48823630
15Abnormal rod and cone electroretinograms (HP:0008323)4.47687971
16Primary atrial arrhythmia (HP:0001692)4.41329865
17Pigmentary retinal degeneration (HP:0001146)4.32631661
18Syncope (HP:0001279)4.26720262
19Supraventricular tachycardia (HP:0004755)4.24397413
20Supraventricular arrhythmia (HP:0005115)4.17237334
21Exercise-induced myalgia (HP:0003738)4.05645049
22Bundle branch block (HP:0011710)4.04119768
23Palpitations (HP:0001962)4.01501690
24Absent rod-and cone-mediated responses on ERG (HP:0007688)3.96317770
25Muscle hypertrophy of the lower extremities (HP:0008968)3.95757780
26Abnormality of the calf musculature (HP:0001430)3.89108273
27Lipoatrophy (HP:0100578)3.87024437
28Hyporeflexia of lower limbs (HP:0002600)3.83926178
29Myoglobinuria (HP:0002913)3.83145693
30Amelogenesis imperfecta (HP:0000705)3.71160845
31Pendular nystagmus (HP:0012043)3.69648404
32Prolonged QT interval (HP:0001657)3.46869582
33Increased connective tissue (HP:0009025)3.40875026
34Ventricular fibrillation (HP:0001663)3.40798806
35Abolished electroretinogram (ERG) (HP:0000550)3.35715616
36Asymmetric septal hypertrophy (HP:0001670)3.33743676
37Abnormality of dental color (HP:0011073)3.24883888
38Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.24519582
39Ventricular arrhythmia (HP:0004308)3.23219401
40Dilated cardiomyopathy (HP:0001644)3.22654595
41Vitreoretinal degeneration (HP:0000655)3.19324148
42Polyuria (HP:0000103)3.17747644
43Heart block (HP:0012722)3.09232093
44Abnormality of midbrain morphology (HP:0002418)3.05190377
45Molar tooth sign on MRI (HP:0002419)3.05190377
46Keratoconus (HP:0000563)3.03235546
47Increased corneal curvature (HP:0100692)3.03235546
48Decreased central vision (HP:0007663)2.97993549
49Abnormality of macular pigmentation (HP:0008002)2.96624691
50Atrioventricular block (HP:0001678)2.95782202
51Dyschromatopsia (HP:0007641)2.94639499
52EMG: myopathic abnormalities (HP:0003458)2.93025564
53Abnormal atrioventricular conduction (HP:0005150)2.92592258
54Abnormality of calcium-phosphate metabolism (HP:0100530)2.91569738
55Difficulty running (HP:0009046)2.89504160
56Abnormality of the left ventricular outflow tract (HP:0011103)2.88866883
57Subaortic stenosis (HP:0001682)2.88866883
58Hemiplegia (HP:0002301)2.86449488
59Posterior subcapsular cataract (HP:0007787)2.85245534
60Rhabdomyolysis (HP:0003201)2.79674335
61Type II diabetes mellitus (HP:0005978)2.76795878
62Overgrowth (HP:0001548)2.73516293
63Constricted visual fields (HP:0001133)2.72920763
64Abnormal urine output (HP:0012590)2.72206766
65Nephronophthisis (HP:0000090)2.70497280
66True hermaphroditism (HP:0010459)2.60715586
67Abnormal mitochondria in muscle tissue (HP:0008316)2.58036675
68Difficulty climbing stairs (HP:0003551)2.55993432
69Abnormal EKG (HP:0003115)2.52146286
70Hypoplastic ischia (HP:0003175)2.49963151
71Left ventricular hypertrophy (HP:0001712)2.48768505
72Acute necrotizing encephalopathy (HP:0006965)2.46983367
73Myotonia (HP:0002486)2.44020020
74Hypoplastic left heart (HP:0004383)2.40660893
75Choroideremia (HP:0001139)2.40304180
76Ketoacidosis (HP:0001993)2.39046333
77Pancreatic fibrosis (HP:0100732)2.35940286
78Medial flaring of the eyebrow (HP:0010747)2.35304454
79Goiter (HP:0000853)2.33190479
80Hemiparesis (HP:0001269)2.31234933
81Photophobia (HP:0000613)2.29186077
82Sudden cardiac death (HP:0001645)2.26429467
83Optic disc pallor (HP:0000543)2.26252493
84Congenital sensorineural hearing impairment (HP:0008527)2.24117530
85Mesangial abnormality (HP:0001966)2.22531906
86Abnormality of renal excretion (HP:0011036)2.21390072
87Acute encephalopathy (HP:0006846)2.20587676
88Pili torti (HP:0003777)2.20062141
89Macular degeneration (HP:0000608)2.19900851
90Pancreatic cysts (HP:0001737)2.18945733
91Gait imbalance (HP:0002141)2.18831202
92Anomalous pulmonary venous return (HP:0010772)2.17752390
93Hypoglycemic coma (HP:0001325)2.16732982
94EMG: neuropathic changes (HP:0003445)2.14497821
95Congenital primary aphakia (HP:0007707)2.14285414
96Abnormality of the ischium (HP:0003174)2.13773780
97Cerebellar dysplasia (HP:0007033)2.13471418
98Hepatic necrosis (HP:0002605)2.11602402
99Abnormality of the pulmonary veins (HP:0011718)2.11587989
100Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.11290785
101Recurrent gram-negative bacterial infections (HP:0005420)2.09593507
102Complement deficiency (HP:0004431)2.09437661
103Conjunctival hamartoma (HP:0100780)2.08179904
104Abnormality of the renal medulla (HP:0100957)2.07532347
105Testicular atrophy (HP:0000029)2.04091335
106Maternal diabetes (HP:0009800)2.01901212
107Abnormality of renal resorption (HP:0011038)2.00921771
108Distal lower limb muscle weakness (HP:0009053)2.00879661
109Abnormality of the dental pulp (HP:0006479)1.99372757
110Progressive macrocephaly (HP:0004481)1.99344668
111Dicarboxylic aciduria (HP:0003215)1.98916479
112Abnormality of dicarboxylic acid metabolism (HP:0010995)1.98916479
113Cerebral edema (HP:0002181)1.98300026
114Subcapsular cataract (HP:0000523)1.98180266
115Palmoplantar keratoderma (HP:0000982)1.97420436
116Polydipsia (HP:0001959)1.94066471
117Abnormal drinking behavior (HP:0030082)1.94066471
118Limb-girdle muscle atrophy (HP:0003797)1.93587315
119Areflexia of lower limbs (HP:0002522)1.92776310
120Prominent supraorbital ridges (HP:0000336)1.92003261
121Chronic bronchitis (HP:0004469)1.91497485
122Muscle stiffness (HP:0003552)1.90993578
123Abnormality of fatty-acid metabolism (HP:0004359)1.90187429
124Increased variability in muscle fiber diameter (HP:0003557)1.90101186
125Renal cortical cysts (HP:0000803)1.89491665
126Bradycardia (HP:0001662)1.88904124
127Nephrogenic diabetes insipidus (HP:0009806)1.87894661
128Hamartoma of the eye (HP:0010568)1.87886948
129Tachypnea (HP:0002789)1.85571550
130Hypoplastic heart (HP:0001961)1.85441405
131Hyperglycinuria (HP:0003108)1.83971131
132Increased muscle lipid content (HP:0009058)1.83305689
133Ragged-red muscle fibers (HP:0003200)1.81597180
134Mitochondrial inheritance (HP:0001427)1.79172531
135Abnormality of serine family amino acid metabolism (HP:0010894)1.79082646
136Abnormality of glycine metabolism (HP:0010895)1.79082646
137Lymphangioma (HP:0100764)1.78713707
138Round ear (HP:0100830)1.78654367
139Decreased circulating renin level (HP:0003351)1.77438824
140Type II lissencephaly (HP:0007260)1.77129495
141Cone-rod dystrophy (HP:0000548)1.74916011
142Dysmetric saccades (HP:0000641)1.74522627
143Myokymia (HP:0002411)1.74104661
144Abnormal respiratory motile cilium physiology (HP:0012261)1.73251249
145Diaphragmatic weakness (HP:0009113)1.72390760
146Pheochromocytoma (HP:0002666)1.71777352
147Pulmonary artery stenosis (HP:0004415)1.71254907
148Abnormality of the fovea (HP:0000493)1.71042617
149Hepatocellular necrosis (HP:0001404)1.70832548
150Metaphyseal cupping (HP:0003021)1.70586870
151Athetosis (HP:0002305)1.69653015
152Neoplasm of head and neck (HP:0012288)1.69058125

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK25.55506048
2TTN4.52058860
3LMTK24.18333453
4PDK33.94270808
5PDK43.94270808
6TRIB33.87454601
7PKN23.62458446
8MYLK3.08072620
9BLK2.91267072
10PHKG22.89021469
11PHKG12.89021469
12NEK12.80480048
13PDK22.78880213
14INSRR2.75184914
15PINK12.46953211
16EPHA32.43620630
17BCKDK2.15307470
18GRK12.14939203
19DDR22.05960604
20ADRBK22.00885147
21WNK31.99740732
22DMPK1.98716459
23TXK1.85745632
24WNK41.75994546
25RIPK11.67131299
26OBSCN1.65541924
27PAK31.51072226
28LATS11.47703332
29PIK3CA1.45688982
30MARK11.39738036
31MAP4K11.39290472
32MAP4K21.38757759
33ICK1.36972532
34PRKCH1.33534725
35PRKCE1.31293748
36STK38L1.31247633
37MUSK1.27331164
38PDGFRA1.21971264
39NTRK31.21847755
40PBK1.10734287
41PRKD11.10163713
42PRKD31.06592965
43STK381.06407632
44CDC42BPA1.03984274
45DAPK20.97784506
46STK240.95064333
47CAMK10.94898867
48CASK0.93812589
49PTK60.92154619
50CAMK2D0.90987898
51STK40.89976196
52TIE10.89342325
53PRKAA10.86231600
54ERN10.83376862
55AKT30.82481235
56MAP3K30.78453958
57ROCK10.77894332
58STK390.77330620
59MAP3K100.77240343
60FER0.76262129
61ILK0.76097729
62CAMK2B0.75714407
63LRRK20.75199583
64NME20.74987884
65PKN10.74950586
66EPHB10.73820400
67WNK10.70372283
68PRKG20.69423015
69PAK40.68589950
70MAPK120.68181565
71EPHA40.67734916
72PRKCQ0.67185824
73CAMK2G0.66928313
74GRK70.66359004
75OXSR10.66185983
76TAOK30.65721534
77TRPM70.64903901
78PRKG10.64107438
79NLK0.62600397
80MAPK130.61402314
81PRKCG0.61366596
82CDK120.59615664
83DAPK30.58473421
84LATS20.58212841
85FES0.57903053
86TLK10.57511529
87GRK50.57018169
88LIMK10.56752727
89MAP3K40.56335787
90MAPK150.56272042
91MAPK40.55910041
92PRKCA0.55813765
93MAP3K70.55440077
94PRKAA20.54662194
95ROCK20.54195580
96CAMK40.53811861
97MTOR0.52971248
98PDPK10.51919251
99FRK0.50352436
100AKT20.49465369
101TYRO30.49308868
102ITK0.49245917
103MARK30.48450488
104MAP3K50.47371595
105FLT30.47343234
106EPHA20.47277827
107MAPKAPK30.47040007
108PRKACG0.47011498
109PDK10.46391939
110MAPKAPK50.43571514
111KSR20.40957075
112HIPK20.39276331
113PRKACB0.39259782
114RPS6KL10.38371110
115RPS6KC10.38371110
116TNK20.38054320
117SRC0.38038384
118ALK0.38019221
119IRAK10.37920228
120RPS6KA50.37387704
121STK110.36552332
122BMPR1B0.36491725
123ERBB40.36063978
124MAP3K60.35939217
125IGF1R0.35594168
126KIT0.35476823
127KDR0.34676787
128PTK2B0.34066330
129RPS6KA10.33836088
130PRKCD0.33791003
131SIK10.33758100
132MET0.30213383
133TTK0.30021236
134STK30.29990955
135CAMK1D0.29735568
136RET0.29048602
137PRKACA0.28768470
138ADRBK10.27080131
139NEK90.26689613
140EPHB20.26650172
141CAMK2A0.26530106
142RPS6KA60.26351592
143CSNK1D0.26160292
144DYRK1B0.25310115
145TGFBR20.24420693
146BMX0.23403321
147FGFR10.18962717
148TAOK10.18200120
149RPS6KA30.17911594
150TESK10.17109945

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047446.71472028
2Citrate cycle (TCA cycle)_Homo sapiens_hsa000205.07445307
32-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.72499455
4Cardiac muscle contraction_Homo sapiens_hsa042603.38756304
5Olfactory transduction_Homo sapiens_hsa047402.92029324
6Dilated cardiomyopathy_Homo sapiens_hsa054142.70013703
7Propanoate metabolism_Homo sapiens_hsa006402.63733889
8Oxidative phosphorylation_Homo sapiens_hsa001902.61981114
9Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.59304844
10Parkinsons disease_Homo sapiens_hsa050122.57667195
11Fatty acid degradation_Homo sapiens_hsa000712.54567257
12Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.49749605
13Carbon metabolism_Homo sapiens_hsa012002.39467692
14Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.14955576
15Morphine addiction_Homo sapiens_hsa050322.14242860
16Fatty acid metabolism_Homo sapiens_hsa012122.05931447
17Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.98129120
18Salivary secretion_Homo sapiens_hsa049701.92542716
19GABAergic synapse_Homo sapiens_hsa047271.91092702
20Alzheimers disease_Homo sapiens_hsa050101.88793336
21Sulfur relay system_Homo sapiens_hsa041221.88490088
22Circadian entrainment_Homo sapiens_hsa047131.88191506
23Insulin secretion_Homo sapiens_hsa049111.83255743
24Pyruvate metabolism_Homo sapiens_hsa006201.79082120
25Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.70878845
26Huntingtons disease_Homo sapiens_hsa050161.66612332
27Glutamatergic synapse_Homo sapiens_hsa047241.65232805
28Taste transduction_Homo sapiens_hsa047421.58452984
29Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.57742257
30Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.53308776
31Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.50503480
32Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.46041611
33* Linoleic acid metabolism_Homo sapiens_hsa005911.42438771
34Nicotine addiction_Homo sapiens_hsa050331.34047145
35Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.29588924
36Butanoate metabolism_Homo sapiens_hsa006501.21261721
37Biosynthesis of amino acids_Homo sapiens_hsa012301.20812675
38Viral myocarditis_Homo sapiens_hsa054161.19654444
39Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.17154130
40Serotonergic synapse_Homo sapiens_hsa047261.08877836
41Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.08259149
42Cocaine addiction_Homo sapiens_hsa050301.07330241
43Fatty acid biosynthesis_Homo sapiens_hsa000611.06484356
44* Pancreatic secretion_Homo sapiens_hsa049721.05550318
45* alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.04924772
46ECM-receptor interaction_Homo sapiens_hsa045121.04440999
47PPAR signaling pathway_Homo sapiens_hsa033201.04111442
48Amphetamine addiction_Homo sapiens_hsa050311.02429683
49* Arachidonic acid metabolism_Homo sapiens_hsa005901.01657936
50Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.00336081
51Complement and coagulation cascades_Homo sapiens_hsa046100.98314166
52Cholinergic synapse_Homo sapiens_hsa047250.95724883
53Fructose and mannose metabolism_Homo sapiens_hsa000510.94777352
54Tyrosine metabolism_Homo sapiens_hsa003500.94068922
55Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.93832029
56Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.91552584
57Collecting duct acid secretion_Homo sapiens_hsa049660.87850405
58Lysine degradation_Homo sapiens_hsa003100.85490224
59Fatty acid elongation_Homo sapiens_hsa000620.85339739
60Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.85220903
61Tight junction_Homo sapiens_hsa045300.84721310
62Histidine metabolism_Homo sapiens_hsa003400.82435366
63cGMP-PKG signaling pathway_Homo sapiens_hsa040220.80955957
64ABC transporters_Homo sapiens_hsa020100.80089117
65Focal adhesion_Homo sapiens_hsa045100.77391337
66Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.76962886
67Central carbon metabolism in cancer_Homo sapiens_hsa052300.76256845
68Adipocytokine signaling pathway_Homo sapiens_hsa049200.75396826
69Starch and sucrose metabolism_Homo sapiens_hsa005000.74276918
70Thyroid hormone signaling pathway_Homo sapiens_hsa049190.73989026
71Primary bile acid biosynthesis_Homo sapiens_hsa001200.73349541
72Staphylococcus aureus infection_Homo sapiens_hsa051500.72378652
73Glucagon signaling pathway_Homo sapiens_hsa049220.71814715
74Chemical carcinogenesis_Homo sapiens_hsa052040.71452772
75Retinol metabolism_Homo sapiens_hsa008300.71422706
76Insulin resistance_Homo sapiens_hsa049310.71148130
77Synaptic vesicle cycle_Homo sapiens_hsa047210.67313345
78Arginine biosynthesis_Homo sapiens_hsa002200.66957188
79HIF-1 signaling pathway_Homo sapiens_hsa040660.66791859
80Steroid hormone biosynthesis_Homo sapiens_hsa001400.66076630
81Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.65443193
82Arginine and proline metabolism_Homo sapiens_hsa003300.65354768
83Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.64654096
84Thyroid hormone synthesis_Homo sapiens_hsa049180.64046424
85Gastric acid secretion_Homo sapiens_hsa049710.64030933
86Galactose metabolism_Homo sapiens_hsa000520.62436115
87Nitrogen metabolism_Homo sapiens_hsa009100.62228259
88Bile secretion_Homo sapiens_hsa049760.62040368
89beta-Alanine metabolism_Homo sapiens_hsa004100.61497358
90Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.61255526
91Aldosterone synthesis and secretion_Homo sapiens_hsa049250.60640161
92Mineral absorption_Homo sapiens_hsa049780.59568059
93Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.59312231
94Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.58661368
95Ovarian steroidogenesis_Homo sapiens_hsa049130.57870973
96Gap junction_Homo sapiens_hsa045400.56625693
97RNA polymerase_Homo sapiens_hsa030200.56508542
98Insulin signaling pathway_Homo sapiens_hsa049100.56191956
99Protein digestion and absorption_Homo sapiens_hsa049740.55843163
100Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.54685496
101AMPK signaling pathway_Homo sapiens_hsa041520.53790357
102Glycerolipid metabolism_Homo sapiens_hsa005610.52419941
103Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.51814063
104Dopaminergic synapse_Homo sapiens_hsa047280.51015164
105Caffeine metabolism_Homo sapiens_hsa002320.50910381
106mTOR signaling pathway_Homo sapiens_hsa041500.48815137
107Pentose phosphate pathway_Homo sapiens_hsa000300.46741739
108Prion diseases_Homo sapiens_hsa050200.44901175
109Cyanoamino acid metabolism_Homo sapiens_hsa004600.40995459
110Sulfur metabolism_Homo sapiens_hsa009200.40263309
111Dorso-ventral axis formation_Homo sapiens_hsa043200.40007251
112Longevity regulating pathway - mammal_Homo sapiens_hsa042110.39863612
113Phenylalanine metabolism_Homo sapiens_hsa003600.39435709
114Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.38900218
115Adherens junction_Homo sapiens_hsa045200.38466149
116* Ether lipid metabolism_Homo sapiens_hsa005650.37783277
117Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.35921514
118Proteoglycans in cancer_Homo sapiens_hsa052050.34129612
119cAMP signaling pathway_Homo sapiens_hsa040240.32376087
120Tryptophan metabolism_Homo sapiens_hsa003800.32368017
121Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.30797436
122Vitamin digestion and absorption_Homo sapiens_hsa049770.30627493
123Small cell lung cancer_Homo sapiens_hsa052220.30621731
124Peroxisome_Homo sapiens_hsa041460.30335808
125Circadian rhythm_Homo sapiens_hsa047100.29357592
126* Metabolic pathways_Homo sapiens_hsa011000.27742191
127Renal cell carcinoma_Homo sapiens_hsa052110.26590849
128Oxytocin signaling pathway_Homo sapiens_hsa049210.26507731
129VEGF signaling pathway_Homo sapiens_hsa043700.26106581
130Cysteine and methionine metabolism_Homo sapiens_hsa002700.26051431
131Renin secretion_Homo sapiens_hsa049240.24594740
132Hippo signaling pathway_Homo sapiens_hsa043900.24264669
133Amoebiasis_Homo sapiens_hsa051460.24222356
134Type II diabetes mellitus_Homo sapiens_hsa049300.18467091
135* Vascular smooth muscle contraction_Homo sapiens_hsa042700.17712917
136Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.17351914
137Leukocyte transendothelial migration_Homo sapiens_hsa046700.16635899
138Inositol phosphate metabolism_Homo sapiens_hsa005620.15421358
139Calcium signaling pathway_Homo sapiens_hsa040200.14899117
140* Fat digestion and absorption_Homo sapiens_hsa049750.14850360
141Autoimmune thyroid disease_Homo sapiens_hsa053200.14274205
142Glutathione metabolism_Homo sapiens_hsa004800.14013247
143Carbohydrate digestion and absorption_Homo sapiens_hsa049730.13925332
144Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.10649038
145Regulation of actin cytoskeleton_Homo sapiens_hsa048100.09519812
146Estrogen signaling pathway_Homo sapiens_hsa049150.09202824

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