PLA2G6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is an A2 phospholipase, a class of enzyme that catalyzes the release of fatty acids from phospholipids. The encoded protein may play a role in phospholipid remodelling, arachidonic acid release, leukotriene and prostaglandin synthesis, fas-mediated apoptosis, and transmembrane ion flux in glucose-stimulated B-cells. Several transcript variants encoding multiple isoforms have been described, but the full-length nature of only three of them have been determined to date. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)6.19895184
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.19895184
3L-phenylalanine metabolic process (GO:0006558)6.03825155
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.03825155
5triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.67153204
6alpha-linolenic acid metabolic process (GO:0036109)5.59097116
7negative regulation of erythrocyte differentiation (GO:0045647)5.30019793
8aromatic amino acid family catabolic process (GO:0009074)5.17008887
9antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.14615539
10positive thymic T cell selection (GO:0045059)5.08549311
11positive regulation of gamma-delta T cell activation (GO:0046645)5.03362207
12fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.91094934
13antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.82442874
14negative regulation of cell killing (GO:0031342)4.80613719
15negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.80613719
16regulation of gamma-delta T cell differentiation (GO:0045586)4.80438340
17antigen processing and presentation of endogenous antigen (GO:0019883)4.77237618
18thymic T cell selection (GO:0045061)4.75885342
19sulfur amino acid catabolic process (GO:0000098)4.74472171
20high-density lipoprotein particle remodeling (GO:0034375)4.72401645
21sperm motility (GO:0030317)4.70072996
22glyoxylate metabolic process (GO:0046487)4.69853108
23negative thymic T cell selection (GO:0045060)4.62843762
24urea cycle (GO:0000050)4.62028231
25urea metabolic process (GO:0019627)4.62028231
26negative regulation of fibrinolysis (GO:0051918)4.59456842
27negative T cell selection (GO:0043383)4.56373121
28kynurenine metabolic process (GO:0070189)4.51255387
29bile acid biosynthetic process (GO:0006699)4.48915968
30positive T cell selection (GO:0043368)4.48860671
31reverse cholesterol transport (GO:0043691)4.44774743
32antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.39773793
33cysteine metabolic process (GO:0006534)4.37744920
34regulation of gamma-delta T cell activation (GO:0046643)4.34860339
35tryptophan catabolic process (GO:0006569)4.34197686
36indole-containing compound catabolic process (GO:0042436)4.34197686
37indolalkylamine catabolic process (GO:0046218)4.34197686
38protein carboxylation (GO:0018214)4.30691863
39peptidyl-glutamic acid carboxylation (GO:0017187)4.30691863
40regulation of triglyceride catabolic process (GO:0010896)4.30345699
41amino-acid betaine metabolic process (GO:0006577)4.29020145
42fusion of sperm to egg plasma membrane (GO:0007342)4.28457276
43nitrogen cycle metabolic process (GO:0071941)4.24556666
44serine family amino acid catabolic process (GO:0009071)4.23218834
45negative regulation of cholesterol transport (GO:0032375)4.21316405
46negative regulation of sterol transport (GO:0032372)4.21316405
47regulation of fibrinolysis (GO:0051917)4.19500500
48plasma lipoprotein particle clearance (GO:0034381)4.18075330
49regulation of cholesterol esterification (GO:0010872)4.17381965
50positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.16093645
51T cell selection (GO:0045058)4.12517977
52tryptophan metabolic process (GO:0006568)4.10173179
53mannose metabolic process (GO:0006013)4.09896377
54sperm-egg recognition (GO:0035036)4.06868125
55glycine metabolic process (GO:0006544)4.04836837
56regulation of protein activation cascade (GO:2000257)4.02182218
57phospholipid efflux (GO:0033700)3.99609818
58bile acid metabolic process (GO:0008206)3.98979949
59acylglycerol homeostasis (GO:0055090)3.98816377
60triglyceride homeostasis (GO:0070328)3.98816377
61binding of sperm to zona pellucida (GO:0007339)3.98815860
62lysine metabolic process (GO:0006553)3.96914365
63lysine catabolic process (GO:0006554)3.96914365
64plasma lipoprotein particle remodeling (GO:0034369)3.96906847
65protein-lipid complex remodeling (GO:0034368)3.96906847
66macromolecular complex remodeling (GO:0034367)3.96906847
67complement activation, alternative pathway (GO:0006957)3.94474437
68coenzyme catabolic process (GO:0009109)3.88401833
69response to interleukin-15 (GO:0070672)3.87947581
70acrosome reaction (GO:0007340)3.81624006
71tyrosine metabolic process (GO:0006570)3.79454258
72regulation of cholesterol homeostasis (GO:2000188)3.79446409
73serine family amino acid biosynthetic process (GO:0009070)3.77527930
74alpha-amino acid catabolic process (GO:1901606)3.76463695
75serine family amino acid metabolic process (GO:0009069)3.76374663
76aromatic amino acid family metabolic process (GO:0009072)3.76289381
77regulation of B cell receptor signaling pathway (GO:0050855)3.75163814
78regulation of complement activation (GO:0030449)3.73629280
79positive regulation of lipoprotein lipase activity (GO:0051006)3.66641347
80positive regulation of triglyceride lipase activity (GO:0061365)3.66641347
81homocysteine metabolic process (GO:0050667)3.62517163
82tolerance induction (GO:0002507)3.61427427
83negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.60778678
84carnitine metabolic process (GO:0009437)3.60596193
85T cell migration (GO:0072678)3.60081503
86positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.59485828
87cell-cell recognition (GO:0009988)3.57902739
88response to muramyl dipeptide (GO:0032495)3.57736935
89cellular amino acid catabolic process (GO:0009063)3.52328893
90organic cation transport (GO:0015695)3.50163909
91plasma lipoprotein particle assembly (GO:0034377)3.49744948
92cellular response to interleukin-15 (GO:0071350)3.48418275
93aspartate family amino acid catabolic process (GO:0009068)3.43875060
94imidazole-containing compound metabolic process (GO:0052803)3.42865936
95negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.41373408
96cholesterol efflux (GO:0033344)3.39252876
97regulation of ARF protein signal transduction (GO:0032012)3.38882378
98leukocyte aggregation (GO:0070486)3.38338500
99B cell receptor signaling pathway (GO:0050853)3.38183817
100fatty acid beta-oxidation (GO:0006635)3.36476259
101activated T cell proliferation (GO:0050798)3.36328967
102fructose metabolic process (GO:0006000)3.36069521
103bile acid and bile salt transport (GO:0015721)3.34266506
104cellular ketone body metabolic process (GO:0046950)3.34192864
105spermatid development (GO:0007286)3.34154382
106cell wall macromolecule metabolic process (GO:0044036)3.31740324
107cell wall macromolecule catabolic process (GO:0016998)3.31740324
108cellular modified amino acid catabolic process (GO:0042219)3.31431944
109cilium or flagellum-dependent cell motility (GO:0001539)3.30038155
110negative regulation of type 2 immune response (GO:0002829)3.29609913
111cofactor catabolic process (GO:0051187)3.28048009
112positive regulation of lipid catabolic process (GO:0050996)3.26667548
113piRNA metabolic process (GO:0034587)3.26274525
114cholesterol homeostasis (GO:0042632)3.25350117
115fatty acid catabolic process (GO:0009062)3.24744566
116L-serine metabolic process (GO:0006563)3.22790367
117positive regulation of triglyceride metabolic process (GO:0090208)3.22778403
118carboxylic acid catabolic process (GO:0046395)3.21754470
119organic acid catabolic process (GO:0016054)3.21754470
120negative regulation of leukocyte mediated immunity (GO:0002704)3.20616817
121fatty acid oxidation (GO:0019395)3.20358659
122ethanol oxidation (GO:0006069)3.18834276
123sterol homeostasis (GO:0055092)3.18791581
124glutamate metabolic process (GO:0006536)3.17608056
125negative regulation of lymphocyte mediated immunity (GO:0002707)3.17456135
126protein-lipid complex assembly (GO:0065005)3.17261620
127positive regulation of B cell differentiation (GO:0045579)3.17006277
128synaptonemal complex assembly (GO:0007130)3.16154483
129acetyl-CoA metabolic process (GO:0006084)3.15405524
130monocarboxylic acid catabolic process (GO:0072329)3.15099959
131germinal center formation (GO:0002467)3.14500765
132arginine metabolic process (GO:0006525)3.14345407
133synaptonemal complex organization (GO:0070193)3.13496493
134lipid oxidation (GO:0034440)3.13476567
135indolalkylamine metabolic process (GO:0006586)3.13404970
136mucosal-associated lymphoid tissue development (GO:0048537)3.13330240
137Peyers patch development (GO:0048541)3.13330240
138positive regulation of granulocyte differentiation (GO:0030854)3.12158116
139positive regulation of fatty acid beta-oxidation (GO:0032000)3.11661509
140regulation of B cell differentiation (GO:0045577)3.08430779
141positive regulation of Rap GTPase activity (GO:0032854)3.03350584
142regulation of granulocyte differentiation (GO:0030852)3.00156856
143positive regulation of histone deacetylation (GO:0031065)2.98597554
144positive regulation of CREB transcription factor activity (GO:0032793)2.90356642
145regulation of ARF GTPase activity (GO:0032312)2.87739284
146histone H4 deacetylation (GO:0070933)2.85966563
147positive regulation by symbiont of host defense response (GO:0052509)2.77440920
148modulation by symbiont of host defense response (GO:0052031)2.77440920
149modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.77440920
150modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.77440920
151positive regulation by organism of defense response of other organism involved in symbiotic interact2.77440920
152modulation by symbiont of host immune response (GO:0052553)2.77440920
153detection of bacterium (GO:0016045)2.73701594
154negative regulation of granulocyte differentiation (GO:0030853)2.71876245
155signal complex assembly (GO:0007172)2.70736482
156negative regulation of myotube differentiation (GO:0010832)2.70062081
157negative regulation of bone resorption (GO:0045779)2.65345161
158lymphocyte migration (GO:0072676)2.63694629
159positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.63082902
160histone H3 deacetylation (GO:0070932)2.57907222
161negative regulation of innate immune response (GO:0045824)2.57724374
162regulation of alpha-beta T cell proliferation (GO:0046640)2.57329833
163antigen receptor-mediated signaling pathway (GO:0050851)2.57167877
164macrophage activation involved in immune response (GO:0002281)2.56492315
165detection of other organism (GO:0098543)2.53492402
166histone H3-K36 demethylation (GO:0070544)2.51288021
167peptidyl-tyrosine autophosphorylation (GO:0038083)2.50837937
168negative regulation of T cell mediated immunity (GO:0002710)2.49892720
169natural killer cell differentiation (GO:0001779)2.49681748
170regulation of natural killer cell mediated immunity (GO:0002715)2.49243125
171regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.49243125
172T cell homeostasis (GO:0043029)2.48610702
173regulation of Rap GTPase activity (GO:0032317)2.46867363
174positive regulation of protein deacetylation (GO:0090312)2.46775303
175interferon-gamma production (GO:0032609)2.45653956
176regulation of monocyte differentiation (GO:0045655)2.43667696
177regulation of myeloid leukocyte mediated immunity (GO:0002886)2.42046439
178regulation of interleukin-4 production (GO:0032673)2.41754748
179T cell receptor signaling pathway (GO:0050852)2.41339498
180CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.38802237
181regulation of necroptotic process (GO:0060544)2.37689971
182dendritic cell chemotaxis (GO:0002407)2.34230624
183positive regulation of tolerance induction (GO:0002645)2.33759199
184regulation of tolerance induction (GO:0002643)2.33373812
185regulation of leukocyte degranulation (GO:0043300)2.31803245
186megakaryocyte development (GO:0035855)2.30931068
187histone H3-K9 modification (GO:0061647)2.30765871
188negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.30157522
189activation of JUN kinase activity (GO:0007257)2.29017745
190negative regulation of interleukin-6 production (GO:0032715)2.28687142
191positive regulation of interleukin-4 production (GO:0032753)2.27005864
192response to type I interferon (GO:0034340)2.25754322
193actin filament polymerization (GO:0030041)2.23112037
194regulation of T cell mediated cytotoxicity (GO:0001914)2.21750042
195regulation of histone deacetylation (GO:0031063)2.21547181
196oxygen transport (GO:0015671)2.20974234
197negative regulation of cAMP-mediated signaling (GO:0043951)2.20748474
198positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.19865507
199lymphocyte homeostasis (GO:0002260)2.19828895

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* ESR1_17901129_ChIP-ChIP_LIVER_Mouse8.60934025
2* RXR_22158963_ChIP-Seq_LIVER_Mouse6.23965375
3* PPARA_22158963_ChIP-Seq_LIVER_Mouse5.65792822
4* LXR_22158963_ChIP-Seq_LIVER_Mouse4.85786330
5EGR1_23403033_ChIP-Seq_LIVER_Mouse4.53873413
6* MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse4.35025010
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.02197452
8PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.01343257
9CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.71614563
10CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.11597089
11VDR_21846776_ChIP-Seq_THP-1_Human3.02781327
12THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.99799847
13KDM2B_26808549_Chip-Seq_SUP-B15_Human2.84197895
14NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.66037609
15MYC_22102868_ChIP-Seq_BL_Human2.62603008
16BP1_19119308_ChIP-ChIP_Hs578T_Human2.58722779
17STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.53383648
18EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.47429383
19KDM2B_26808549_Chip-Seq_DND41_Human2.45552770
20IRF8_22096565_ChIP-ChIP_GC-B_Human2.44829631
21KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.42386994
22DROSHA_22980978_ChIP-Seq_HELA_Human2.30911419
23* TCF7_22412390_ChIP-Seq_EML_Mouse2.30530758
24E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.22970464
25EZH2_22144423_ChIP-Seq_EOC_Human2.19260365
26TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.15320630
27VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.13913667
28UTX_26944678_Chip-Seq_JUKART_Human2.06174886
29* MAF_26560356_Chip-Seq_TH1_Human1.99365841
30KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.96206404
31MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.94767311
32RUNX_20019798_ChIP-Seq_JUKART_Human1.94651079
33VDR_24763502_ChIP-Seq_THP-1_Human1.93709230
34TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.93321412
35SCL_19346495_ChIP-Seq_HPC-7_Human1.92810532
36PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.90917016
37MAF_26560356_Chip-Seq_TH2_Human1.87265386
38IKZF1_21737484_ChIP-ChIP_HCT116_Human1.83292346
39RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.83176870
40KDM2B_26808549_Chip-Seq_K562_Human1.79776393
41* ELK3_25401928_ChIP-Seq_HUVEC_Human1.79689291
42GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.78652429
43KDM2B_26808549_Chip-Seq_JURKAT_Human1.78136027
44TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.74747283
45MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.73677200
46SA1_27219007_Chip-Seq_ERYTHROID_Human1.70797921
47DNAJC2_21179169_ChIP-ChIP_NT2_Human1.67684448
48EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.67635810
49GATA1_19941827_ChIP-Seq_MEL_Mouse1.64899045
50CTCF_27219007_Chip-Seq_ERYTHROID_Human1.62911745
51RUNX1_22412390_ChIP-Seq_EML_Mouse1.62904533
52RXRA_24833708_ChIP-Seq_LIVER_Mouse1.55400428
53ERG_21242973_ChIP-ChIP_JURKAT_Human1.49229653
54* TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.46612421
55IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.43983652
56STAT3_1855785_ChIP-Seq_MESCs_Mouse1.42838002
57CREB1_26743006_Chip-Seq_LNCaP_Human1.42246031
58RACK7_27058665_Chip-Seq_MCF-7_Human1.42238895
59FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.41178744
60MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.40595807
61GATA1_19941826_ChIP-Seq_K562_Human1.40233780
62POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.39243959
63RARA_24833708_ChIP-Seq_LIVER_Mouse1.38478388
64SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.36495956
65TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.35993847
66SPI1_23127762_ChIP-Seq_K562_Human1.35564866
67TET1_21451524_ChIP-Seq_MESCs_Mouse1.32547976
68* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.32160274
69SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.25438954
70ZFP281_18757296_ChIP-ChIP_E14_Mouse1.24994148
71ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.23665879
72MYB_26560356_Chip-Seq_TH2_Human1.22557060
73GATA1_22025678_ChIP-Seq_K562_Human1.22547170
74FOXA2_19822575_ChIP-Seq_HepG2_Human1.22215736
75GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.19204754
76CLOCK_20551151_ChIP-Seq_293T_Human1.19150967
77OCT4_19829295_ChIP-Seq_ESCs_Human1.18480183
78RARB_24833708_ChIP-Seq_LIVER_Mouse1.18109134
79TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.18071781
80NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.17938967
81SUZ12_27294783_Chip-Seq_ESCs_Mouse1.17279945
82* RARG_19884340_ChIP-ChIP_MEFs_Mouse1.17108238
83SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.16457936
84ELF1_20517297_ChIP-Seq_JURKAT_Human1.16397658
85MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.16261340
86HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.15639789
87SA1_27219007_Chip-Seq_Bcells_Human1.15591887
88HNF4A_19822575_ChIP-Seq_HepG2_Human1.15323405
89NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.14578657
90* MYB_26560356_Chip-Seq_TH1_Human1.14102028
91ZFP281_27345836_Chip-Seq_ESCs_Mouse1.13422957
92* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.12961508
93CTCF_21964334_ChIP-Seq_BJAB-B_Human1.12144319
94CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.11787031
95SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.11206562
96EZH2_27294783_Chip-Seq_ESCs_Mouse1.11190522
97NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.10347366
98ESR2_21235772_ChIP-Seq_MCF-7_Human1.10213960
99YY1_22570637_ChIP-Seq_MALME-3M_Human1.10073425
100CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.09437342
101* PU.1_20513432_ChIP-Seq_Bcells_Mouse1.09259770
102ZNF263_19887448_ChIP-Seq_K562_Human1.08269537
103PHF8_20622854_ChIP-Seq_HELA_Human1.07910445
104RUNX1_27514584_Chip-Seq_MCF-7_Human1.07842210
105GATA3_27048872_Chip-Seq_THYMUS_Human1.06036946
106BRD4_27068464_Chip-Seq_AML-cells_Mouse1.05843392
107SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.05528543
108LXR_22292898_ChIP-Seq_THP-1_Human1.05469364
109FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.05214896
110* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.04752757
111RARB_27405468_Chip-Seq_BRAIN_Mouse1.03558268
112LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.00907088
113UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.00685479
114EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.00158158
115BCOR_27268052_Chip-Seq_Bcells_Human0.99785069
116GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99552112
117NCOR1_26117541_ChIP-Seq_K562_Human0.98878966
118GATA1_22383799_ChIP-Seq_G1ME_Mouse0.98627613
119VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.98462797
120STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.97256124
121RAD21_21589869_ChIP-Seq_MESCs_Mouse0.96668210
122P68_20966046_ChIP-Seq_HELA_Human0.96620010
123SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.95206112
124CTCF_20526341_ChIP-Seq_ESCs_Human0.94780765
125* SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.93890885
126PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.93604193
127* SOX2_22085726_ChIP-Seq_NPCs_Mouse0.91508988
128SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.91417555
129E2F1_20622854_ChIP-Seq_HELA_Human0.91320105
130PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.90829481
131BCL6_27268052_Chip-Seq_Bcells_Human0.90278506
132CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.89805984
133P53_21459846_ChIP-Seq_SAOS-2_Human0.89704411
134GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.88269918
135POU5F1_16518401_ChIP-PET_MESCs_Mouse0.86922392
136SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.86686630
137NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.86505716
138* CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.84902543
139FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.84158418
140* MYC_18358816_ChIP-ChIP_MESCs_Mouse0.83594761
141ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.83559734
142SPI1_26923725_Chip-Seq_HPCs_Mouse0.82596274
143LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.81601606
144EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.81344580
145PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.81281285
146* KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.80741113
147KLF4_18555785_ChIP-Seq_MESCs_Mouse0.80310241
148FOXP1_21924763_ChIP-Seq_HESCs_Human0.80190439
149SRY_22984422_ChIP-ChIP_TESTIS_Rat0.77761618
150GATA3_21867929_ChIP-Seq_CD8_Mouse0.76831860
151ESET_19884257_ChIP-Seq_ESCs_Mouse0.76613497
152KAP1_22055183_ChIP-Seq_ESCs_Mouse0.76445329
153ETS1_21867929_ChIP-Seq_TH2_Mouse0.76345936
154SPI1_20517297_ChIP-Seq_HL60_Human0.75287156
155CTCF_26484167_Chip-Seq_Bcells_Mouse0.74241708
156* MYCN_18555785_ChIP-Seq_MESCs_Mouse0.73926015
157SOX2_21211035_ChIP-Seq_LN229_Human0.73786418
158SMC4_20622854_ChIP-Seq_HELA_Human0.73729048
159CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.73044318
160* SOX2_18692474_ChIP-Seq_MESCs_Mouse0.72555683
161STAT1_17558387_ChIP-Seq_HELA_Human0.72454680
162SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.72425833
163KAP1_27257070_Chip-Seq_ESCs_Mouse0.71207806
164JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.71029660
165CTCF_27219007_Chip-Seq_Bcells_Human0.70778175
166POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.70598946
167CTCF_21964334_Chip-Seq_Bcells_Human0.70356174
168SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.70338151
169STAT6_21828071_ChIP-Seq_BEAS2B_Human0.70006689
170POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.69218758
171NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.68394749
172NFIB_24661679_ChIP-Seq_LUNG_Mouse0.68248583
173DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.67969474
174ERG_20517297_ChIP-Seq_VCAP_Human0.67447462
175SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.67256561
176RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.67155581
177* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.66763742
178HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.66586021
179* TP63_22573176_ChIP-Seq_HFKS_Human0.66302948
180* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.66112082

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.21830531
2MP0005360_urolithiasis6.14773858
3MP0005365_abnormal_bile_salt5.57754050
4MP0005085_abnormal_gallbladder_physiolo5.05875701
5MP0005410_abnormal_fertilization4.71901848
6MP0003806_abnormal_nucleotide_metabolis4.49687564
7MP0008875_abnormal_xenobiotic_pharmacok3.88935586
8MP0003252_abnormal_bile_duct3.50646764
9MP0003436_decreased_susceptibility_to3.48576844
10MP0009840_abnormal_foam_cell3.43127871
11MP0010329_abnormal_lipoprotein_level3.20449535
12MP0003763_abnormal_thymus_physiology2.93091781
13MP0005670_abnormal_white_adipose2.82999639
14MP0005671_abnormal_response_to2.58815183
15MP0009278_abnormal_bone_marrow2.55315724
16MP0005083_abnormal_biliary_tract2.55307606
17MP0001800_abnormal_humoral_immune2.46686557
18MP0005332_abnormal_amino_acid2.40572647
19MP0003195_calcinosis2.38723710
20MP0003724_increased_susceptibility_to2.36115551
21MP0001835_abnormal_antigen_presentation2.28931482
22MP0001666_abnormal_nutrient_absorption2.20874324
23MP0005000_abnormal_immune_tolerance2.20675501
24MP0004381_abnormal_hair_follicle2.10749056
25MP0001790_abnormal_immune_system2.10036014
26MP0005387_immune_system_phenotype2.10036014
27MP0004859_abnormal_synaptic_plasticity2.07036909
28MP0005025_abnormal_response_to2.06848460
29MP0000685_abnormal_immune_system2.03854059
30MP0000609_abnormal_liver_physiology2.01669787
31MP0002723_abnormal_immune_serum2.01194699
32MP0002420_abnormal_adaptive_immunity1.99608544
33MP0003172_abnormal_lysosome_physiology1.96260019
34MP0001819_abnormal_immune_cell1.96199259
35MP0002118_abnormal_lipid_homeostasis1.94143374
36MP0003303_peritoneal_inflammation1.91857930
37MP0002822_catalepsy1.87524116
38MP0001986_abnormal_taste_sensitivity1.82356887
39MP0002419_abnormal_innate_immunity1.79607225
40MP0002132_abnormal_respiratory_system1.78580803
41MP0003690_abnormal_glial_cell1.76921364
42MP0003866_abnormal_defecation1.76822191
43MP0004019_abnormal_vitamin_homeostasis1.76304826
44* MP0002398_abnormal_bone_marrow1.75761154
45* MP0003698_abnormal_male_reproductive1.73908903
46MP0002452_abnormal_antigen_presenting1.71956494
47MP0001929_abnormal_gametogenesis1.71876697
48MP0003191_abnormal_cellular_cholesterol1.67554638
49MP0005319_abnormal_enzyme/_coenzyme1.66587955
50MP0004947_skin_inflammation1.66457044
51MP0001873_stomach_inflammation1.65699897
52MP0005423_abnormal_somatic_nervous1.63513181
53MP0010155_abnormal_intestine_physiology1.62692482
54MP0009333_abnormal_splenocyte_physiolog1.61386382
55* MP0000716_abnormal_immune_system1.60370671
56MP0003868_abnormal_feces_composition1.59040109
57MP0002653_abnormal_ependyma_morphology1.57155769
58MP0003183_abnormal_peptide_metabolism1.57073438
59MP0001764_abnormal_homeostasis1.57005341
60MP0004858_abnormal_nervous_system1.52651088
61MP0000703_abnormal_thymus_morphology1.48427077
62MP0005397_hematopoietic_system_phenotyp1.46930564
63MP0001545_abnormal_hematopoietic_system1.46930564
64MP0002933_joint_inflammation1.44606087
65MP0002722_abnormal_immune_system1.37551787
66MP0002405_respiratory_system_inflammati1.35328138
67MP0002396_abnormal_hematopoietic_system1.34375441
68MP0005464_abnormal_platelet_physiology1.34025370
69MP0000689_abnormal_spleen_morphology1.31593444
70MP0009643_abnormal_urine_homeostasis1.29998898
71MP0003011_delayed_dark_adaptation1.27785959
72MP0005584_abnormal_enzyme/coenzyme_acti1.26983818
73MP0003705_abnormal_hypodermis_morpholog1.24755612
74* MP0002429_abnormal_blood_cell1.23209362
75MP0001533_abnormal_skeleton_physiology1.22862336
76MP0003879_abnormal_hair_cell1.22683333
77MP0000598_abnormal_liver_morphology1.22474907
78MP0008260_abnormal_autophagy1.22387247
79MP0002138_abnormal_hepatobiliary_system1.18200819
80MP0008569_lethality_at_weaning1.17221812
81MP0005666_abnormal_adipose_tissue1.16740381
82MP0002249_abnormal_larynx_morphology1.14915593
83MP0003635_abnormal_synaptic_transmissio1.13216721
84MP0005377_hearing/vestibular/ear_phenot1.11545557
85MP0003878_abnormal_ear_physiology1.11545557
86MP0003186_abnormal_redox_activity1.11490022
87MP0009785_altered_susceptibility_to1.11251086
88* MP0002161_abnormal_fertility/fecundity1.10223958
89MP0005076_abnormal_cell_differentiation1.10124691
90MP0003329_amyloid_beta_deposits1.10113473
91MP0005310_abnormal_salivary_gland1.09882425
92* MP0002063_abnormal_learning/memory/cond1.07830533
93MP0003300_gastrointestinal_ulcer1.07510144
94MP0001502_abnormal_circadian_rhythm1.07145911
95MP0001348_abnormal_lacrimal_gland1.06874608
96MP0008877_abnormal_DNA_methylation1.05017149
97MP0000465_gastrointestinal_hemorrhage1.04836996
98MP0001501_abnormal_sleep_pattern1.04755244
99MP0002078_abnormal_glucose_homeostasis1.04363819
100MP0005266_abnormal_metabolism1.02944865
101MP0004264_abnormal_extraembryonic_tissu1.02472307
102MP0000604_amyloidosis1.01932781
103MP0005451_abnormal_body_composition1.00944086
104MP0002210_abnormal_sex_determination0.99440088
105MP0005220_abnormal_exocrine_pancreas0.99407625
106MP0001851_eye_inflammation0.99082617
107MP0009672_abnormal_birth_weight0.98754899
108MP0005058_abnormal_lysosome_morphology0.96795853
109MP0001845_abnormal_inflammatory_respons0.96602180
110MP0006036_abnormal_mitochondrial_physio0.95883044
111MP0001145_abnormal_male_reproductive0.95084819
112MP0002148_abnormal_hypersensitivity_rea0.94223600
113MP0005535_abnormal_body_temperature0.93301822
114MP0005075_abnormal_melanosome_morpholog0.93106341
115MP0003880_abnormal_central_pattern0.93046772
116MP0005647_abnormal_sex_gland0.93030201
117MP0005636_abnormal_mineral_homeostasis0.92017618
118MP0001661_extended_life_span0.89072061
119MP0002064_seizures0.88645280
120MP0001486_abnormal_startle_reflex0.86366902
121MP0002971_abnormal_brown_adipose0.85852736
122MP0010368_abnormal_lymphatic_system0.84660940
123MP0001663_abnormal_digestive_system0.84215507
124MP0000653_abnormal_sex_gland0.83795299
125MP0005334_abnormal_fat_pad0.83370901
126MP0003045_fibrosis0.83139905
127MP0003283_abnormal_digestive_organ0.82651637
128MP0009697_abnormal_copulation0.80465192
129MP0008995_early_reproductive_senescence0.80265561
130MP0004185_abnormal_adipocyte_glucose0.78830799
131MP0008874_decreased_physiological_sensi0.78350682
132MP0005376_homeostasis/metabolism_phenot0.77848328
133MP0000639_abnormal_adrenal_gland0.77789761
134MP0002638_abnormal_pupillary_reflex0.76958121
135MP0005375_adipose_tissue_phenotype0.76839528
136MP0002998_abnormal_bone_remodeling0.76551494
137MP0009642_abnormal_blood_homeostasis0.76482286
138MP0002735_abnormal_chemical_nociception0.74020728
139MP0002970_abnormal_white_adipose0.73699073
140MP0009745_abnormal_behavioral_response0.72755018
141MP0002733_abnormal_thermal_nociception0.72628198
142MP0004130_abnormal_muscle_cell0.72118661
143MP0003656_abnormal_erythrocyte_physiolo0.71617706
144MP0000358_abnormal_cell_content/0.71022031
145MP0006082_CNS_inflammation0.70983486
146MP0001944_abnormal_pancreas_morphology0.70886421
147MP0000858_altered_metastatic_potential0.70495588
148MP0001756_abnormal_urination0.70148951
149* MP0002269_muscular_atrophy0.69728849
150MP0006035_abnormal_mitochondrial_morpho0.69232952
151MP0001970_abnormal_pain_threshold0.67247549
152MP0002166_altered_tumor_susceptibility0.66328475
153* MP0002572_abnormal_emotion/affect_behav0.66324588
154MP0008961_abnormal_basal_metabolism0.65863294
155MP0005448_abnormal_energy_balance0.64815074
156MP0009763_increased_sensitivity_to0.64087086
157MP0004233_abnormal_muscle_weight0.64082962
158MP0002837_dystrophic_cardiac_calcinosis0.60933728
159MP0001730_embryonic_growth_arrest0.59742666
160MP0003953_abnormal_hormone_level0.58708502
161MP0003890_abnormal_embryonic-extraembry0.57338471
162MP0009115_abnormal_fat_cell0.55045402
163MP0004133_heterotaxia0.54358442
164MP0002928_abnormal_bile_duct0.53573804
165MP0003959_abnormal_lean_body0.52423072
166MP0003115_abnormal_respiratory_system0.51830529
167MP0000003_abnormal_adipose_tissue0.51661700
168MP0005408_hypopigmentation0.48100660
169MP0005395_other_phenotype0.46786544
170MP0001849_ear_inflammation0.46634993
171MP0003119_abnormal_digestive_system0.45850508
172MP0000678_abnormal_parathyroid_gland0.44974296
173MP0004197_abnormal_fetal_growth/weight/0.43844811
174MP0002909_abnormal_adrenal_gland0.43747708
175MP0002693_abnormal_pancreas_physiology0.43448262
176MP0002254_reproductive_system_inflammat0.42984981
177MP0003699_abnormal_female_reproductive0.42864475
178MP0004043_abnormal_pH_regulation0.42494498
179MP0003718_maternal_effect0.42346411
180MP0001765_abnormal_ion_homeostasis0.40989968
181MP0008469_abnormal_protein_level0.39300349
182MP0002697_abnormal_eye_size0.38784367
183MP0009053_abnormal_anal_canal0.38031215
184MP0005084_abnormal_gallbladder_morpholo0.37111340
185MP0001672_abnormal_embryogenesis/_devel0.37015238

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)6.33243847
2Intrahepatic cholestasis (HP:0001406)6.28158670
3Deep venous thrombosis (HP:0002625)5.99594848
4Abnormality of monocarboxylic acid metabolism (HP:0010996)5.85627312
5Xanthomatosis (HP:0000991)5.52053937
6Hypobetalipoproteinemia (HP:0003563)5.39083547
7Prolonged partial thromboplastin time (HP:0003645)4.60615142
8Eczematoid dermatitis (HP:0000976)4.42438480
9Hypoglycemic coma (HP:0001325)4.41133090
10Ketosis (HP:0001946)4.39670302
11Panhypogammaglobulinemia (HP:0003139)4.37467446
12Hyperlipoproteinemia (HP:0010980)4.35194792
13Hypolipoproteinemia (HP:0010981)4.27053558
14Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.24652372
15Obstructive sleep apnea (HP:0002870)4.12800010
16Hyperammonemia (HP:0001987)4.00900165
17Hyperglycinemia (HP:0002154)3.96368021
18Hypoalphalipoproteinemia (HP:0003233)3.92270363
19Complement deficiency (HP:0004431)3.92121190
20Absent/shortened dynein arms (HP:0200106)3.88161047
21Dynein arm defect of respiratory motile cilia (HP:0012255)3.88161047
22Abnormality of sulfur amino acid metabolism (HP:0004339)3.82155616
23Hyperinsulinemic hypoglycemia (HP:0000825)3.75388909
24Abnormality of methionine metabolism (HP:0010901)3.73875926
25Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.72974271
26Agammaglobulinemia (HP:0004432)3.71827373
27Hyperglycinuria (HP:0003108)3.65983514
28Cholecystitis (HP:0001082)3.61882749
29Abnormal gallbladder physiology (HP:0012438)3.61882749
30Epidermoid cyst (HP:0200040)3.61179769
31Hypercholesterolemia (HP:0003124)3.57615331
32Abnormality of aspartate family amino acid metabolism (HP:0010899)3.56989221
33Abnormality of glycine metabolism (HP:0010895)3.56425167
34Abnormality of serine family amino acid metabolism (HP:0010894)3.56425167
35Colitis (HP:0002583)3.49245915
36Chronic otitis media (HP:0000389)3.48015435
37Elevated erythrocyte sedimentation rate (HP:0003565)3.44871477
38Abnormality of the intrinsic pathway (HP:0010989)3.42138150
39Abnormal delayed hypersensitivity skin test (HP:0002963)3.41556306
40Abnormality of the fingertips (HP:0001211)3.40302956
41Hypoglycemic seizures (HP:0002173)3.39280845
42Recurrent fungal infections (HP:0002841)3.33686562
43Abnormality of pyrimidine metabolism (HP:0004353)3.32247019
44Myositis (HP:0100614)3.30822902
45Ketoacidosis (HP:0001993)3.29926826
46Abnormality of the common coagulation pathway (HP:0010990)3.27178846
47Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.24638394
48Meningitis (HP:0001287)3.23339466
49Increased IgE level (HP:0003212)3.19850230
50Gastrointestinal infarctions (HP:0005244)3.16981020
51Late onset (HP:0003584)3.16846625
52Chronic bronchitis (HP:0004469)3.14286208
53Joint hemorrhage (HP:0005261)3.14058527
54Fat malabsorption (HP:0002630)3.13643109
55Abnormality of glutamine family amino acid metabolism (HP:0010902)3.11904905
56Gastrointestinal inflammation (HP:0004386)3.07515378
57Abnormality of the lower motor neuron (HP:0002366)3.06243015
58Papilledema (HP:0001085)3.04652864
59Hyperbilirubinemia (HP:0002904)3.02474762
60Prolonged bleeding time (HP:0003010)3.01312183
61Inflammation of the large intestine (HP:0002037)2.94139413
62Abnormality of fatty-acid metabolism (HP:0004359)2.88166882
63Abnormality of complement system (HP:0005339)2.84522407
64Infertility (HP:0000789)2.83854737
65Hypochromic anemia (HP:0001931)2.76805372
66Mediastinal lymphadenopathy (HP:0100721)2.75183577
67Abnormality of nucleobase metabolism (HP:0010932)2.75138803
68Recurrent bronchitis (HP:0002837)2.73610656
69Conjugated hyperbilirubinemia (HP:0002908)2.72255838
70Abnormality of serum amino acid levels (HP:0003112)2.72228389
71Abnormal respiratory motile cilium physiology (HP:0012261)2.71805957
72Pustule (HP:0200039)2.71787928
73Recurrent viral infections (HP:0004429)2.70723251
74Hemorrhage of the eye (HP:0011885)2.69943788
75Orchitis (HP:0100796)2.67777162
76Encephalitis (HP:0002383)2.67037078
77Cellulitis (HP:0100658)2.65612430
78Recurrent cutaneous fungal infections (HP:0011370)2.58240417
79Chronic mucocutaneous candidiasis (HP:0002728)2.58240417
80Myoglobinuria (HP:0002913)2.56861598
81Annular pancreas (HP:0001734)2.55808244
82Recurrent bacterial skin infections (HP:0005406)2.55755005
83Skin nodule (HP:0200036)2.53941343
84Recurrent abscess formation (HP:0002722)2.53936195
85Malnutrition (HP:0004395)2.53631555
86Abnormal gallbladder morphology (HP:0012437)2.52873447
87Abnormality of binocular vision (HP:0011514)2.49232857
88Diplopia (HP:0000651)2.49232857
89T lymphocytopenia (HP:0005403)2.47625093
90Abnormality of dicarboxylic acid metabolism (HP:0010995)2.47158447
91Dicarboxylic aciduria (HP:0003215)2.47158447
92Chronic obstructive pulmonary disease (HP:0006510)2.46982537
93Obstructive lung disease (HP:0006536)2.46982537
94Gout (HP:0001997)2.46586905
95Abnormality of purine metabolism (HP:0004352)2.46584695
96Spontaneous hematomas (HP:0007420)2.42841282
97Nasal polyposis (HP:0100582)2.42073540
98Retrobulbar optic neuritis (HP:0100654)2.40332209
99Optic neuritis (HP:0100653)2.40332209
100Abnormal respiratory epithelium morphology (HP:0012253)2.39498206
101Abnormal respiratory motile cilium morphology (HP:0005938)2.39498206
102Broad face (HP:0000283)2.39267651
103Cholelithiasis (HP:0001081)2.38735408
104Metaphyseal cupping (HP:0003021)2.36265588
105Brushfield spots (HP:0001088)2.34953117
106Granulocytopenia (HP:0001913)2.32974405
107Back pain (HP:0003418)2.31160669
108Hemiplegia (HP:0002301)2.30380747
109Vasculitis (HP:0002633)2.30123567
110Seborrheic dermatitis (HP:0001051)2.30064011
111Irritability (HP:0000737)2.29733739
112Spastic diplegia (HP:0001264)2.28838448
113Abnormality of T cells (HP:0002843)2.26537020
114Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.25404927
115Hepatocellular carcinoma (HP:0001402)2.24237497
116Chronic sinusitis (HP:0011109)2.22965540
117Hyperglycemia (HP:0003074)2.22720230
118Metabolic acidosis (HP:0001942)2.22665467
119Severe combined immunodeficiency (HP:0004430)2.21386096
120Emphysema (HP:0002097)2.21216395
121Rhinitis (HP:0012384)2.20733524
122Stomatitis (HP:0010280)2.20551699
123Abnormality of endocrine pancreas physiology (HP:0012093)2.20389747
124Abnormality of the pancreatic islet cells (HP:0006476)2.20389747
125Abnormality of T cell number (HP:0011839)2.18680961
126Abnormality of macrophages (HP:0004311)2.18153125
127Upper motor neuron abnormality (HP:0002127)2.15210519
128Vascular calcification (HP:0004934)2.15199555
129Gastrointestinal stroma tumor (HP:0100723)2.14509207
130Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.14479518
131Symptomatic seizures (HP:0011145)2.13690926
132Lethargy (HP:0001254)2.13056349
133Chest pain (HP:0100749)2.12442840
134Gingivitis (HP:0000230)2.10097335
135Enlarged kidneys (HP:0000105)2.09436260
136Abnormality of the heme biosynthetic pathway (HP:0010472)2.08543629
137Steatorrhea (HP:0002570)2.08024128
138Verrucae (HP:0200043)2.07886178
139Papilloma (HP:0012740)2.07886178
140Acanthocytosis (HP:0001927)2.07828562
141Delayed CNS myelination (HP:0002188)2.07497139
142Myocardial infarction (HP:0001658)2.05887163
143Ankle clonus (HP:0011448)2.04801551
144Recurrent otitis media (HP:0000403)2.04754562
145Recurrent sinusitis (HP:0011108)2.04371907
146Rhabdomyolysis (HP:0003201)2.04276941
147Insulin resistance (HP:0000855)2.03676875
148Recurrent skin infections (HP:0001581)2.03381122
149Abnormality of the gallbladder (HP:0005264)2.03250084
150Supernumerary ribs (HP:0005815)2.03161111
151Supernumerary bones of the axial skeleton (HP:0009144)2.01895053
152Reticulocytosis (HP:0001923)2.01864123
153Recurrent gram-negative bacterial infections (HP:0005420)1.98625075
154Pancreatitis (HP:0001733)1.98533372
155Abnormality of the nasal mucosa (HP:0000433)1.98500136
156Spontaneous abortion (HP:0005268)1.98203814
157Hypochromic microcytic anemia (HP:0004840)1.97442149
158Epistaxis (HP:0000421)1.94620246
159Deep palmar crease (HP:0006191)1.93637635
160Sleep apnea (HP:0010535)1.93540238
161Growth hormone excess (HP:0000845)1.92132356
162Spinal canal stenosis (HP:0003416)1.89673772
163Bronchomalacia (HP:0002780)1.86718371
164Cardiovascular calcification (HP:0011915)1.86711062
165Joint swelling (HP:0001386)1.86680509
166Atelectasis (HP:0100750)1.86573429
167Bile duct proliferation (HP:0001408)1.86159414
168Abnormal biliary tract physiology (HP:0012439)1.86159414
169Pulmonary infiltrates (HP:0002113)1.85528632
170Hypoplasia of the thymus (HP:0000778)1.85444818
171Genetic anticipation (HP:0003743)1.84939091
172Hemoptysis (HP:0002105)1.84729393
173Restrictive lung disease (HP:0002091)1.83649108
174Bronchitis (HP:0012387)1.83079933
175Neonatal onset (HP:0003623)1.82718196
176Abnormality of vitamin metabolism (HP:0100508)1.80865925
177Increased serum ferritin (HP:0003281)1.80835374
178Leukocytosis (HP:0001974)1.80591956
179Male infertility (HP:0003251)1.80446774
180Thoracic kyphosis (HP:0002942)1.80289870
181Hypertriglyceridemia (HP:0002155)1.79383187
182Generalized aminoaciduria (HP:0002909)1.78079589
183Onion bulb formation (HP:0003383)1.76734092
184Retinal atrophy (HP:0001105)1.76144477
185Mitral stenosis (HP:0001718)1.74741728
186Abnormality of T cell physiology (HP:0011840)1.74205870
187Keratoconjunctivitis sicca (HP:0001097)1.74143888
188Germ cell neoplasia (HP:0100728)1.73054680
189Slow saccadic eye movements (HP:0000514)1.73016898
190Easy fatigability (HP:0003388)1.72886217

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK44.69323211
2PDK34.69323211
3BCKDK4.24364059
4ICK3.65983650
5PRKD33.59714371
6MAP4K13.46191395
7SIK13.34518274
8TESK13.33643634
9ERN13.32588413
10RIPK43.15108833
11MAP3K132.88019129
12TNK22.64156891
13PDK22.54624505
14PRPF4B2.46026408
15TRIB32.22688195
16SIK21.97621299
17FGFR41.96638490
18MET1.92423976
19TXK1.88822912
20PASK1.84166902
21TAOK31.82819018
22PKN21.82558775
23INSRR1.73082910
24FES1.66397067
25MAPK151.64684872
26FLT31.64414275
27EPHA21.64217423
28NEK21.63349828
29DYRK1B1.60600035
30CDK121.60081630
31TYK21.57026944
32ZAP701.53566350
33EEF2K1.52054388
34BTK1.44587826
35CAMKK11.35671626
36MAP3K101.35205756
37MTOR1.27579479
38PTK61.26645222
39PRKD21.24040543
40STK38L1.21488635
41WNK41.21213801
42MAP3K61.19844754
43PTK2B1.19072423
44PTK21.18407171
45ITK1.15026978
46IKBKE1.14024352
47SYK1.12827393
48JAK31.11086834
49TTK1.10641021
50SMG11.09598161
51BLK1.08832709
52LATS11.08319537
53ERBB41.07706241
54MAP3K141.07023884
55DYRK31.06696570
56STK381.05987084
57NTRK31.05151335
58RPS6KA21.04113194
59TBK11.03243011
60CSK1.03177198
61MAPK121.01217934
62PIK3CG1.01114176
63IRAK41.00150657
64MAPK70.99772840
65HCK0.99018998
66WNK30.98387420
67RPS6KC10.97501017
68RPS6KL10.97501017
69HIPK20.96815635
70TESK20.95871202
71PNCK0.95493732
72LCK0.92262064
73RPS6KA60.91909838
74NEK10.88104179
75TAOK10.87305750
76EPHB10.83295145
77JAK10.82994313
78CDC42BPA0.82703680
79PAK40.81348688
80TYRO30.79982609
81NTRK20.79925214
82PRKCH0.78629378
83BMX0.76172643
84DAPK20.75240797
85KIT0.72400381
86RIPK10.72139943
87UHMK10.71983853
88CAMK1G0.70351104
89KSR20.68308936
90LYN0.68202339
91SIK30.68042446
92PRKAA10.67702172
93IKBKB0.67667454
94CAMK1D0.66106094
95LATS20.64225897
96STK110.63826738
97CAMK10.63354721
98WEE10.61687720
99RET0.61193052
100MAPK110.60688931
101KDR0.59604025
102FYN0.57836707
103SGK2230.57648045
104SGK4940.57648045
105PDGFRA0.55426371
106MAPK40.55332921
107PAK20.55277174
108MAP2K30.54415329
109PINK10.53665795
110NTRK10.52960196
111MAP2K60.52959157
112SGK20.52170941
113ATR0.51985596
114SGK30.50649807
115MAP2K40.50603685
116MARK30.49992089
117MAP3K80.49112883
118MAP2K20.48478228
119CDK60.48005683
120CDK40.47743542
121PDK10.47524908
122STK30.46345477
123STK100.45586643
124PRKCQ0.45357772
125TLK10.45278552
126MAPK30.45226230
127CHUK0.44007095
128RPS6KA10.43789678
129PIM10.43346139
130MAPK130.41641282
131TEC0.41529968
132CSF1R0.41475378
133MAPKAPK30.41080843
134BUB10.40744775
135GRK60.38901820
136MARK20.38841279
137CDK70.38234376
138CHEK20.37088292
139CHEK10.36857321
140PRKAA20.36472676
141GSK3A0.36173103
142PLK10.34716353
143PRKACG0.33776643
144CDC70.33687527
145ATM0.33561064
146ERBB20.33386064
147MAP3K110.32885077
148FGFR10.32681732
149PDPK10.31639660
150MAP3K70.29070917
151PAK10.28867449
152MAP3K10.28227678
153JAK20.27943988
154IRAK10.27858293
155AURKA0.27648514
156CSNK1E0.26676196
157PRKCZ0.25600712
158AKT20.25493306
159CDK20.25087406
160RPS6KA40.24999583
161PAK60.23038200
162TGFBR20.21578580
163MAPK10.20893480

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.60699445
2Nitrogen metabolism_Homo sapiens_hsa009102.85561680
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.77956574
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.70119009
5Fatty acid degradation_Homo sapiens_hsa000712.68494835
6Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.65380035
7Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.60985813
8Primary immunodeficiency_Homo sapiens_hsa053402.56761142
9Selenocompound metabolism_Homo sapiens_hsa004502.50529089
10Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.43970989
11Tryptophan metabolism_Homo sapiens_hsa003802.42327667
12Arginine biosynthesis_Homo sapiens_hsa002202.41204413
13Propanoate metabolism_Homo sapiens_hsa006402.32069145
14Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.30704325
15B cell receptor signaling pathway_Homo sapiens_hsa046622.29796170
16Fatty acid metabolism_Homo sapiens_hsa012122.14131147
17Complement and coagulation cascades_Homo sapiens_hsa046102.09895696
18Pyruvate metabolism_Homo sapiens_hsa006202.08828826
19PPAR signaling pathway_Homo sapiens_hsa033202.08176226
20Acute myeloid leukemia_Homo sapiens_hsa052212.07260942
21T cell receptor signaling pathway_Homo sapiens_hsa046602.01174902
22Maturity onset diabetes of the young_Homo sapiens_hsa049501.97568044
23Notch signaling pathway_Homo sapiens_hsa043301.97499599
24Peroxisome_Homo sapiens_hsa041461.87983414
25Butanoate metabolism_Homo sapiens_hsa006501.87415695
26Pentose and glucuronate interconversions_Homo sapiens_hsa000401.86802531
27Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.86440507
28Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.79737235
29Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.78872096
30Vitamin B6 metabolism_Homo sapiens_hsa007501.75568555
31Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.75155017
32Osteoclast differentiation_Homo sapiens_hsa043801.73745318
33Biosynthesis of amino acids_Homo sapiens_hsa012301.70466666
34Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.68815921
35Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.67163352
36Fat digestion and absorption_Homo sapiens_hsa049751.66109420
37Chemical carcinogenesis_Homo sapiens_hsa052041.65783330
38VEGF signaling pathway_Homo sapiens_hsa043701.65762261
39Carbon metabolism_Homo sapiens_hsa012001.65469003
40Cysteine and methionine metabolism_Homo sapiens_hsa002701.63931231
41Graft-versus-host disease_Homo sapiens_hsa053321.63624506
422-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.63164111
43Drug metabolism - other enzymes_Homo sapiens_hsa009831.59109053
44Autoimmune thyroid disease_Homo sapiens_hsa053201.53597751
45Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.53148060
46Leishmaniasis_Homo sapiens_hsa051401.52042698
47Allograft rejection_Homo sapiens_hsa053301.50816231
48* Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.47766571
49Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.42145346
50Histidine metabolism_Homo sapiens_hsa003401.39928046
51Phospholipase D signaling pathway_Homo sapiens_hsa040721.38454317
52beta-Alanine metabolism_Homo sapiens_hsa004101.38358594
53Bile secretion_Homo sapiens_hsa049761.36237435
54Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.35849350
55Non-small cell lung cancer_Homo sapiens_hsa052231.33887379
56Sulfur metabolism_Homo sapiens_hsa009201.33775203
57Steroid hormone biosynthesis_Homo sapiens_hsa001401.31917474
58Toll-like receptor signaling pathway_Homo sapiens_hsa046201.31066295
59Phenylalanine metabolism_Homo sapiens_hsa003601.30635132
60ABC transporters_Homo sapiens_hsa020101.30200450
61One carbon pool by folate_Homo sapiens_hsa006701.29036928
62Phosphatidylinositol signaling system_Homo sapiens_hsa040701.28604102
63Choline metabolism in cancer_Homo sapiens_hsa052311.28221936
64Chemokine signaling pathway_Homo sapiens_hsa040621.23199000
65Sulfur relay system_Homo sapiens_hsa041221.22118435
66Fatty acid elongation_Homo sapiens_hsa000621.20682190
67Folate biosynthesis_Homo sapiens_hsa007901.20288654
68Retinol metabolism_Homo sapiens_hsa008301.19856746
69RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.18914065
70Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.18667007
71Tyrosine metabolism_Homo sapiens_hsa003501.17962216
72Chronic myeloid leukemia_Homo sapiens_hsa052201.17316839
73Starch and sucrose metabolism_Homo sapiens_hsa005001.16456911
74Fatty acid biosynthesis_Homo sapiens_hsa000611.15367814
75GnRH signaling pathway_Homo sapiens_hsa049121.14479491
76Glycerolipid metabolism_Homo sapiens_hsa005611.14034151
77NF-kappa B signaling pathway_Homo sapiens_hsa040641.13606382
78Pentose phosphate pathway_Homo sapiens_hsa000301.13435963
79Neurotrophin signaling pathway_Homo sapiens_hsa047221.12900355
80Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.12704590
81Fructose and mannose metabolism_Homo sapiens_hsa000511.12195014
82Aldosterone synthesis and secretion_Homo sapiens_hsa049251.09161631
83Inositol phosphate metabolism_Homo sapiens_hsa005621.07024828
84Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.05849144
85mTOR signaling pathway_Homo sapiens_hsa041501.05585147
86* Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.05340789
87Measles_Homo sapiens_hsa051621.04305387
88Lysine degradation_Homo sapiens_hsa003101.04133671
89Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.00971200
90Caffeine metabolism_Homo sapiens_hsa002321.00144664
91TNF signaling pathway_Homo sapiens_hsa046681.00088881
92Cholinergic synapse_Homo sapiens_hsa047250.99602813
93Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.99271978
94Long-term potentiation_Homo sapiens_hsa047200.98610077
95Prolactin signaling pathway_Homo sapiens_hsa049170.97307677
96ErbB signaling pathway_Homo sapiens_hsa040120.97159594
97Jak-STAT signaling pathway_Homo sapiens_hsa046300.97115588
98Arginine and proline metabolism_Homo sapiens_hsa003300.95712793
99Platelet activation_Homo sapiens_hsa046110.95006226
100Intestinal immune network for IgA production_Homo sapiens_hsa046720.94420526
101Steroid biosynthesis_Homo sapiens_hsa001000.91674303
102Type I diabetes mellitus_Homo sapiens_hsa049400.91479890
103Hematopoietic cell lineage_Homo sapiens_hsa046400.90992067
104Influenza A_Homo sapiens_hsa051640.90249489
105Hepatitis C_Homo sapiens_hsa051600.89694095
106Staphylococcus aureus infection_Homo sapiens_hsa051500.88614810
107Toxoplasmosis_Homo sapiens_hsa051450.88489333
108Glutathione metabolism_Homo sapiens_hsa004800.87244318
109Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.87073782
110MAPK signaling pathway_Homo sapiens_hsa040100.86878070
111Thyroid hormone signaling pathway_Homo sapiens_hsa049190.85482082
112NOD-like receptor signaling pathway_Homo sapiens_hsa046210.84426567
113Cyanoamino acid metabolism_Homo sapiens_hsa004600.84027591
114Antigen processing and presentation_Homo sapiens_hsa046120.83123651
115Endometrial cancer_Homo sapiens_hsa052130.82590364
116Tuberculosis_Homo sapiens_hsa051520.81703908
117Morphine addiction_Homo sapiens_hsa050320.81342735
118Estrogen signaling pathway_Homo sapiens_hsa049150.80098390
119Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.79399793
120Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.77826815
121Oxytocin signaling pathway_Homo sapiens_hsa049210.76720854
122Herpes simplex infection_Homo sapiens_hsa051680.76672273
123Hepatitis B_Homo sapiens_hsa051610.75957915
124Galactose metabolism_Homo sapiens_hsa000520.75928381
125Pancreatic cancer_Homo sapiens_hsa052120.74839347
126Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.74497109
127Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.71372132
128Glucagon signaling pathway_Homo sapiens_hsa049220.70946836
129Leukocyte transendothelial migration_Homo sapiens_hsa046700.70921252
130Circadian entrainment_Homo sapiens_hsa047130.70872457
131Vitamin digestion and absorption_Homo sapiens_hsa049770.70794316
132Colorectal cancer_Homo sapiens_hsa052100.70231430
133Gastric acid secretion_Homo sapiens_hsa049710.69762394
134* alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.69496805
135Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.68980807
136cAMP signaling pathway_Homo sapiens_hsa040240.67035395
137Rap1 signaling pathway_Homo sapiens_hsa040150.66845421
138Amphetamine addiction_Homo sapiens_hsa050310.66832539
139Apoptosis_Homo sapiens_hsa042100.65899693
140Renal cell carcinoma_Homo sapiens_hsa052110.65693122
141FoxO signaling pathway_Homo sapiens_hsa040680.65218613
142Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.64966385
143Malaria_Homo sapiens_hsa051440.64650250
144Glioma_Homo sapiens_hsa052140.63776036
145* Vascular smooth muscle contraction_Homo sapiens_hsa042700.61953068
146Endocytosis_Homo sapiens_hsa041440.61507609
147Viral myocarditis_Homo sapiens_hsa054160.59711753
148Calcium signaling pathway_Homo sapiens_hsa040200.59286998
149AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.58842786
150Sphingolipid signaling pathway_Homo sapiens_hsa040710.58186029
151Dorso-ventral axis formation_Homo sapiens_hsa043200.57529477
152HTLV-I infection_Homo sapiens_hsa051660.57364479
153Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.57143806
154Cocaine addiction_Homo sapiens_hsa050300.55414798
155Ovarian steroidogenesis_Homo sapiens_hsa049130.53811069
156* Linoleic acid metabolism_Homo sapiens_hsa005910.53520811
157* Glycerophospholipid metabolism_Homo sapiens_hsa005640.52312603
158Glutamatergic synapse_Homo sapiens_hsa047240.52128600
159* Ras signaling pathway_Homo sapiens_hsa040140.51449832
160* Metabolic pathways_Homo sapiens_hsa011000.51313574
161Insulin resistance_Homo sapiens_hsa049310.42828082
162Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.42791765
163AMPK signaling pathway_Homo sapiens_hsa041520.41844781
164Adipocytokine signaling pathway_Homo sapiens_hsa049200.38861545
165Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.35022780
166Carbohydrate digestion and absorption_Homo sapiens_hsa049730.34245570
167Glycosaminoglycan degradation_Homo sapiens_hsa005310.33828922
168Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.33641650
169Central carbon metabolism in cancer_Homo sapiens_hsa052300.33540742
170Prion diseases_Homo sapiens_hsa050200.26515173
171Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.15288906
172Insulin signaling pathway_Homo sapiens_hsa049100.12670583
173Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.12100175
174RNA transport_Homo sapiens_hsa030130.05074911
175Type II diabetes mellitus_Homo sapiens_hsa049300.04213475
176Renin-angiotensin system_Homo sapiens_hsa046140.03535854
177Pyrimidine metabolism_Homo sapiens_hsa002400.03354675
178Longevity regulating pathway - mammal_Homo sapiens_hsa042110.01322139
179Ubiquitin mediated proteolysis_Homo sapiens_hsa04120-0.1353076
180Systemic lupus erythematosus_Homo sapiens_hsa05322-0.1210774
181Purine metabolism_Homo sapiens_hsa00230-0.1112115
182Insulin secretion_Homo sapiens_hsa04911-0.0937818
183Bladder cancer_Homo sapiens_hsa05219-0.0591362
184Thyroid hormone synthesis_Homo sapiens_hsa04918-0.0335482
185N-Glycan biosynthesis_Homo sapiens_hsa00510-0.0282750
186Other glycan degradation_Homo sapiens_hsa00511-0.0043973

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