PLA2G7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a secreted enzyme that catalyzes the degradation of platelet-activating factor to biologically inactive products. Defects in this gene are a cause of platelet-activating factor acetylhydrolase deficiency. Two transcript variants encoding the same protein have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1oligosaccharide catabolic process (GO:0009313)5.96730071
2glycosphingolipid catabolic process (GO:0046479)5.92488725
3positive regulation of cellular amide metabolic process (GO:0034250)5.71703296
4negative regulation of interleukin-12 production (GO:0032695)5.42442418
5glycolipid catabolic process (GO:0019377)5.32973883
6cellular response to thyroid hormone stimulus (GO:0097067)5.23910272
7L-amino acid import (GO:0043092)5.14883741
8amino acid import (GO:0043090)5.00972535
9ceramide catabolic process (GO:0046514)4.90201273
10alanine transport (GO:0032328)4.70626295
11cellular potassium ion homeostasis (GO:0030007)4.62541045
12amino sugar catabolic process (GO:0046348)4.58586657
13sodium ion export (GO:0071436)4.43932524
14regulation of cholesterol storage (GO:0010885)4.37869909
15negative regulation of amyloid precursor protein catabolic process (GO:1902992)4.24434084
16positive regulation by symbiont of host defense response (GO:0052509)4.21478685
17modulation by symbiont of host defense response (GO:0052031)4.21478685
18modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.21478685
19modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.21478685
20positive regulation by organism of defense response of other organism involved in symbiotic interact4.21478685
21modulation by symbiont of host immune response (GO:0052553)4.21478685
22microglial cell activation (GO:0001774)4.10277472
23positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.94122119
24C4-dicarboxylate transport (GO:0015740)3.93539502
25response to thyroid hormone (GO:0097066)3.92308134
26membrane lipid catabolic process (GO:0046466)3.89425928
27regulation of beta-amyloid formation (GO:1902003)3.86291993
28cell communication by electrical coupling (GO:0010644)3.80672718
29N-acetylneuraminate metabolic process (GO:0006054)3.74778465
30sphingolipid catabolic process (GO:0030149)3.71423392
31positive regulation of leukocyte degranulation (GO:0043302)3.65224879
32positive regulation of gamma-delta T cell activation (GO:0046645)3.64533353
33regulation of vitamin D biosynthetic process (GO:0060556)3.57283624
34immunoglobulin mediated immune response (GO:0016064)3.55467790
35gamma-aminobutyric acid transport (GO:0015812)3.55343800
36detection of molecule of bacterial origin (GO:0032490)3.52844578
37negative regulation of nitric oxide biosynthetic process (GO:0045019)3.51213014
38response to auditory stimulus (GO:0010996)3.47683565
39negative regulation of astrocyte differentiation (GO:0048712)3.46868469
40regulation of macrophage chemotaxis (GO:0010758)3.42113503
41regulation of activation of Janus kinase activity (GO:0010533)3.40459683
42positive regulation of antigen processing and presentation (GO:0002579)3.39507190
43cellular sodium ion homeostasis (GO:0006883)3.37089087
44fat-soluble vitamin biosynthetic process (GO:0042362)3.36870782
45potassium ion import (GO:0010107)3.30915090
46myeloid dendritic cell differentiation (GO:0043011)3.30423757
47regulation of mast cell degranulation (GO:0043304)3.27541120
48regulation of amyloid precursor protein catabolic process (GO:1902991)3.24756158
49negative regulation of hydrogen peroxide-induced cell death (GO:1903206)3.24680510
50regulation of cellular amide metabolic process (GO:0034248)3.22663757
51regulation of mast cell activation (GO:0033003)3.22379081
52monocyte chemotaxis (GO:0002548)3.22196613
53regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.21195456
54acidic amino acid transport (GO:0015800)3.20655443
55interferon-gamma-mediated signaling pathway (GO:0060333)3.18194266
56macrophage activation involved in immune response (GO:0002281)3.17925506
57positive regulation of cholesterol efflux (GO:0010875)3.17497655
58proline transport (GO:0015824)3.16973506
59cellular response to cholesterol (GO:0071397)3.15834271
60regulation of heat generation (GO:0031650)3.14741036
61neurotransmitter-gated ion channel clustering (GO:0072578)3.13106859
62phagosome maturation (GO:0090382)3.11313017
63cellular extravasation (GO:0045123)3.11286497
64eosinophil chemotaxis (GO:0048245)3.10919455
65regulation of podosome assembly (GO:0071801)3.10897855
66regulation of mast cell activation involved in immune response (GO:0033006)3.10131963
67hydrogen peroxide biosynthetic process (GO:0050665)3.09366024
68serine transport (GO:0032329)3.08826615
69positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.08293369
70cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.08120105
71ganglioside metabolic process (GO:0001573)3.07617580
72regulation of interleukin-12 production (GO:0032655)3.04171113
73positive regulation of myeloid leukocyte mediated immunity (GO:0002888)3.04046830
74regulation of antigen processing and presentation (GO:0002577)3.03072921
75regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.01715667
76myeloid dendritic cell activation (GO:0001773)3.01215297
77regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.99366097
78regulation of T cell tolerance induction (GO:0002664)2.98745041
79positive regulation of toll-like receptor signaling pathway (GO:0034123)2.98626873
80L-serine transport (GO:0015825)2.97916350
81negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.96667198
82regulation of leukocyte degranulation (GO:0043300)2.96145874
83regulation of interferon-beta biosynthetic process (GO:0045357)2.95521190
84superoxide anion generation (GO:0042554)2.92884394
85dendritic cell differentiation (GO:0097028)2.91724952
86negative regulation of response to reactive oxygen species (GO:1901032)2.90932598
87negative regulation of lipid storage (GO:0010888)2.90148400
88NIK/NF-kappaB signaling (GO:0038061)2.88989665
89neurotransmitter uptake (GO:0001504)2.88347239
90positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.88339058
91keratan sulfate catabolic process (GO:0042340)2.88254431
92L-glutamate transport (GO:0015813)2.87218900
93response to host immune response (GO:0052572)2.87153948
94response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.87153948
95regulation of cytokine secretion involved in immune response (GO:0002739)2.86581819
96detection of other organism (GO:0098543)2.86435797
97locomotory exploration behavior (GO:0035641)2.85934757
98positive regulation of chemokine biosynthetic process (GO:0045080)2.85763927
99detection of external biotic stimulus (GO:0098581)2.85091348
100vitamin D metabolic process (GO:0042359)2.84811386
101regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.84065425
102regulation of T-helper 1 cell differentiation (GO:0045625)2.83078476
103negative regulation of interleukin-1 beta production (GO:0032691)2.82792521
104regulation of interferon-alpha production (GO:0032647)2.82391330
105antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.82090191
106intracellular pH reduction (GO:0051452)2.81688083
107regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.80605347
108positive regulation of heat generation (GO:0031652)2.80461143
109positive regulation of type 2 immune response (GO:0002830)2.80250249
110potassium ion homeostasis (GO:0055075)2.78816932
111negative regulation of synaptic transmission, GABAergic (GO:0032229)2.78468004
112regulation of vitamin metabolic process (GO:0030656)2.77909717
113T-helper 1 type immune response (GO:0042088)2.77857882
114membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.77301655
115regulation of hydrogen peroxide-induced cell death (GO:1903205)2.76539740
116cellular response to lipopolysaccharide (GO:0071222)2.76341313
117regulation of membrane protein ectodomain proteolysis (GO:0051043)2.75680501
118regulation of toll-like receptor 4 signaling pathway (GO:0034143)2.75033677
119osteoclast differentiation (GO:0030316)2.74800439
120macrophage activation (GO:0042116)2.74687970
121positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.74214593
122lysosome organization (GO:0007040)2.73304504
123lytic vacuole organization (GO:0080171)2.73304504
124cellular response to molecule of bacterial origin (GO:0071219)2.72263978
125eosinophil migration (GO:0072677)2.71966679
126regulation of fever generation (GO:0031620)2.71958267
127positive regulation of sterol transport (GO:0032373)2.71739070
128positive regulation of cholesterol transport (GO:0032376)2.71739070
129negative regulation of sodium ion transport (GO:0010766)2.69893247
130neutrophil activation involved in immune response (GO:0002283)2.69508454
131reactive oxygen species biosynthetic process (GO:1903409)2.69154598
132positive regulation of mast cell activation involved in immune response (GO:0033008)2.67746639
133positive regulation of mast cell degranulation (GO:0043306)2.67746639
134response to host (GO:0075136)2.67136269
135response to host defenses (GO:0052200)2.67136269
136response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.67136269
137positive regulation of macrophage cytokine production (GO:0060907)2.66820779
138chondroitin sulfate catabolic process (GO:0030207)2.66032343
139positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.64878744
140ovulation cycle (GO:0042698)2.62791833
141regulation of astrocyte differentiation (GO:0048710)2.59333485
142cellular response to sterol (GO:0036315)2.58287190
143positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.56221011
144positive regulation of mast cell activation (GO:0033005)2.52414428
145negative regulation of interleukin-17 production (GO:0032700)2.51326625
146response to peptidoglycan (GO:0032494)2.48383966
147chronic inflammatory response (GO:0002544)2.47955114
148dermatan sulfate metabolic process (GO:0030205)2.47478473
149response to cholesterol (GO:0070723)2.46902650
150cGMP-mediated signaling (GO:0019934)2.41148084
151dermatan sulfate biosynthetic process (GO:0030208)2.40536167
152lipopolysaccharide-mediated signaling pathway (GO:0031663)2.38602922
153neuronal action potential propagation (GO:0019227)2.38506758
154positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.37872510
155positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.37654415
156G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.37591058
157positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.35275014
158phagocytosis, engulfment (GO:0006911)2.34998891
159cerebellar granule cell differentiation (GO:0021707)2.32155351
160ionotropic glutamate receptor signaling pathway (GO:0035235)2.31666803
161positive regulation of interferon-alpha production (GO:0032727)2.31553746
162phagocytosis, recognition (GO:0006910)2.31395845
163negative regulation of homotypic cell-cell adhesion (GO:0034111)2.30185936
164glial cell proliferation (GO:0014009)2.30028460
165glutamate receptor signaling pathway (GO:0007215)2.29705797
166cellular response to exogenous dsRNA (GO:0071360)2.28737760
167positive regulation of alcohol biosynthetic process (GO:1902932)2.26947098
168L-amino acid transport (GO:0015807)2.26490887
169regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.26454627
170atrial cardiac muscle cell action potential (GO:0086014)2.25198820
171regulation of mononuclear cell migration (GO:0071675)2.24489354
172respiratory burst (GO:0045730)2.23990925
173granulocyte activation (GO:0036230)2.23157919

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human3.07378829
2MYB_21317192_ChIP-Seq_ERMYB_Mouse2.93591277
3MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.92378646
4IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.75397107
5IRF8_21731497_ChIP-ChIP_J774_Mouse2.71168917
6IKZF1_21737484_ChIP-ChIP_HCT116_Human2.60603749
7STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.55761950
8EZH2_22144423_ChIP-Seq_EOC_Human2.49636957
9GATA1_22025678_ChIP-Seq_K562_Human2.48927672
10SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.45742222
11SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.37423706
12SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.36489419
13GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.26232693
14SPI1_23127762_ChIP-Seq_K562_Human2.20325418
15STAT4_19710469_ChIP-ChIP_TH1__Mouse2.17808451
16SPI1_23547873_ChIP-Seq_NB4_Human2.16794931
17SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.13771350
18SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.13397328
19SMAD_19615063_ChIP-ChIP_OVARY_Human2.08787048
20SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.07871786
21BRD4_27068464_Chip-Seq_AML-cells_Mouse2.03413095
22CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.03384753
23PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse2.03364501
24MTF2_20144788_ChIP-Seq_MESCs_Mouse2.01359537
25JARID2_20064375_ChIP-Seq_MESCs_Mouse2.00321125
26EED_16625203_ChIP-ChIP_MESCs_Mouse1.99751349
27RNF2_18974828_ChIP-Seq_MESCs_Mouse1.97723291
28EZH2_18974828_ChIP-Seq_MESCs_Mouse1.97723291
29IRF8_22096565_ChIP-ChIP_GC-B_Human1.92988516
30GBX2_23144817_ChIP-Seq_PC3_Human1.92837022
31SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.92756573
32JARID2_20075857_ChIP-Seq_MESCs_Mouse1.91064511
33RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.87530751
34* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.86988120
35VDR_24763502_ChIP-Seq_THP-1_Human1.85817297
36* IRF8_27001747_Chip-Seq_BMDM_Mouse1.84073543
37SCL_19346495_ChIP-Seq_HPC-7_Human1.82727993
38* CDX2_19796622_ChIP-Seq_MESCs_Mouse1.82040748
39LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.81484756
40THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.80638307
41AR_21572438_ChIP-Seq_LNCaP_Human1.76706297
42RNF2_27304074_Chip-Seq_ESCs_Mouse1.72737322
43CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.71828755
44PU_27001747_Chip-Seq_BMDM_Mouse1.71133655
45SUZ12_27294783_Chip-Seq_ESCs_Mouse1.56911441
46EZH2_27294783_Chip-Seq_ESCs_Mouse1.56684939
47REST_21632747_ChIP-Seq_MESCs_Mouse1.54477613
48MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.53932140
49NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.53693049
50MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.50196789
51DROSHA_22980978_ChIP-Seq_HELA_Human1.49643514
52EZH2_27304074_Chip-Seq_ESCs_Mouse1.48010780
53LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.47360400
54SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.47212949
55TFEB_21752829_ChIP-Seq_HELA_Human1.44737237
56TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.44076492
57RUNX1_22412390_ChIP-Seq_EML_Mouse1.40845115
58BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.39099668
59RXR_22108803_ChIP-Seq_LS180_Human1.38937419
60CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.37349473
61CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.35855166
62VDR_24787735_ChIP-Seq_THP-1_Human1.35705321
63STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.35129427
64NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.34331030
65NRF2_20460467_ChIP-Seq_MEFs_Mouse1.34331030
66IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.32234268
67* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.31492208
68E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.29831462
69RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.24903839
70AR_25329375_ChIP-Seq_VCAP_Human1.24059005
71P300_19829295_ChIP-Seq_ESCs_Human1.23604601
72VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.23210112
73CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.23019434
74PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.21668036
75TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.21315447
76GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.20474198
77TP53_18474530_ChIP-ChIP_U2OS_Human1.19056827
78GATA2_21666600_ChIP-Seq_HMVEC_Human1.18063482
79MYB_26560356_Chip-Seq_TH2_Human1.17985032
80VDR_21846776_ChIP-Seq_THP-1_Human1.17931376
81BCAT_22108803_ChIP-Seq_LS180_Human1.17006864
82TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.16650201
83SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.16143298
84PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.15655492
85GATA1_19941827_ChIP-Seq_MEL_Mouse1.14913060
86SMAD4_21799915_ChIP-Seq_A2780_Human1.14163597
87PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.13285845
88TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.12785130
89TRIM28_21343339_ChIP-Seq_HEK293_Human1.12461292
90STAT1_20625510_ChIP-Seq_HELA_Human1.11870298
91NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.11638660
92SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.11582218
93GATA1_19941826_ChIP-Seq_K562_Human1.10128961
94PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.08573063
95PIAS1_25552417_ChIP-Seq_VCAP_Human1.08315631
96FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.08237873
97SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.07224220
98NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.07079902
99RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.06971796
100ZFP57_27257070_Chip-Seq_ESCs_Mouse1.06609588
101GATA3_26560356_Chip-Seq_TH2_Human1.06377298
102FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.06158051
103ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.05454818
104NR3C1_21868756_ChIP-Seq_MCF10A_Human1.05284717
105CBX2_27304074_Chip-Seq_ESCs_Mouse1.05271393
106ERG_21242973_ChIP-ChIP_JURKAT_Human1.03997896
107* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.03604141
108NR3C1_23031785_ChIP-Seq_PC12_Mouse1.03338165
109REST_18959480_ChIP-ChIP_MESCs_Mouse1.03015506
110FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.02897734
111STAT6_21828071_ChIP-Seq_BEAS2B_Human1.02877517
112CTBP2_25329375_ChIP-Seq_LNCAP_Human1.02728610
113FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.02452324
114GATA3_27048872_Chip-Seq_THYMUS_Human0.99710250
115PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.99404694
116EGR1_19374776_ChIP-ChIP_THP-1_Human0.98461573
117RING1B_27294783_Chip-Seq_ESCs_Mouse0.96080269
118ZNF217_24962896_ChIP-Seq_MCF-7_Human0.96055034
119SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.95652276
120SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.95136678
121CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.93425445
122ESR2_21235772_ChIP-Seq_MCF-7_Human0.91082749
123TP53_16413492_ChIP-PET_HCT116_Human0.90803639
124* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.90660873
125OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.89846129
126LXR_22158963_ChIP-Seq_LIVER_Mouse0.89518260
127RUNX_20019798_ChIP-Seq_JUKART_Human0.89358576
128MAF_26560356_Chip-Seq_TH1_Human0.88316925
129AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.87006333
130TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.86447323
131JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.86044886
132STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.85401268
133SMAD3_21741376_ChIP-Seq_EPCs_Human0.85006599
134CJUN_26792858_Chip-Seq_BT549_Human0.84917990
135TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.84726205
136* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.84587265
137TOP2B_26459242_ChIP-Seq_MCF-7_Human0.83935131
138EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.83698260
139GATA2_22383799_ChIP-Seq_G1ME_Mouse0.83439268
140TP53_20018659_ChIP-ChIP_R1E_Mouse0.83371668
141TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.82938905
142SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.82036722
143CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.81664636
144CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.79900884
145AR_19668381_ChIP-Seq_PC3_Human0.79792973
146TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.79711287
147PRDM14_20953172_ChIP-Seq_ESCs_Human0.79366225
148GATA2_19941826_ChIP-Seq_K562_Human0.78697845
149WT1_25993318_ChIP-Seq_PODOCYTE_Human0.78671458
150E2F1_18555785_Chip-Seq_ESCs_Mouse0.78579056
151RARB_27405468_Chip-Seq_BRAIN_Mouse0.78358027
152GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.78009186
153SOX2_21211035_ChIP-Seq_LN229_Gbm0.77676311
154JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.77424573
155STAT3_23295773_ChIP-Seq_U87_Human0.77334682
156TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.77107173
157CTBP1_25329375_ChIP-Seq_LNCAP_Human0.77076704
158TCF4_22108803_ChIP-Seq_LS180_Human0.76999285
159GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.76335260
160SMAD4_21741376_ChIP-Seq_HESCs_Human0.76230970
161KDM2B_26808549_Chip-Seq_SUP-B15_Human0.75989136
162VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.75826705
163RXR_22158963_ChIP-Seq_LIVER_Mouse0.74367150
164MYB_26560356_Chip-Seq_TH1_Human0.74192561
165GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.73913190
166* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.72938685
167SMRT_27268052_Chip-Seq_Bcells_Human0.72648312
168LXR_22292898_ChIP-Seq_THP-1_Human0.70553301
169ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.70195817
170SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.69432824
171PPARA_22158963_ChIP-Seq_LIVER_Mouse0.68163891
172GATA1_19941827_ChIP-Seq_MEL86_Mouse0.67392484
173SOX2_20726797_ChIP-Seq_SW620_Human0.67253337
174ESR1_21235772_ChIP-Seq_MCF-7_Human0.66790867
175GATA1_22383799_ChIP-Seq_G1ME_Mouse0.65598693
176BCL6_27268052_Chip-Seq_Bcells_Human0.65454007

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003690_abnormal_glial_cell3.99847279
2MP0004858_abnormal_nervous_system3.69002471
3MP0003191_abnormal_cellular_cholesterol2.89156728
4MP0002139_abnormal_hepatobiliary_system2.88301861
5MP0003075_altered_response_to2.87960541
6MP0003136_yellow_coat_color2.71312536
7MP0002254_reproductive_system_inflammat2.71068761
8MP0003329_amyloid_beta_deposits2.67886737
9MP0004859_abnormal_synaptic_plasticity2.65389136
10MP0005058_abnormal_lysosome_morphology2.56251876
11MP0001853_heart_inflammation2.42338068
12MP0000604_amyloidosis2.38065640
13MP0005167_abnormal_blood-brain_barrier2.29192688
14MP0009046_muscle_twitch2.27827371
15MP0004885_abnormal_endolymph2.14220771
16MP0002736_abnormal_nociception_after2.04453541
17MP0001968_abnormal_touch/_nociception1.96614840
18MP0005646_abnormal_pituitary_gland1.94863657
19MP0002148_abnormal_hypersensitivity_rea1.91094220
20MP0003634_abnormal_glial_cell1.91046467
21MP0005451_abnormal_body_composition1.90430813
22MP0003300_gastrointestinal_ulcer1.86480397
23MP0003635_abnormal_synaptic_transmissio1.84453399
24MP0004270_analgesia1.84173337
25MP0003279_aneurysm1.82450139
26MP0003633_abnormal_nervous_system1.81185920
27MP0002419_abnormal_innate_immunity1.79895474
28MP0005166_decreased_susceptibility_to1.79653167
29MP0001800_abnormal_humoral_immune1.77579243
30MP0005423_abnormal_somatic_nervous1.76028628
31MP0002064_seizures1.75229862
32MP0002638_abnormal_pupillary_reflex1.74876345
33MP0001486_abnormal_startle_reflex1.73796254
34MP0003806_abnormal_nucleotide_metabolis1.72652430
35MP0001845_abnormal_inflammatory_respons1.69203914
36MP0001440_abnormal_grooming_behavior1.69103354
37MP0002735_abnormal_chemical_nociception1.68366948
38MP0003172_abnormal_lysosome_physiology1.68038591
39MP0003878_abnormal_ear_physiology1.67862020
40MP0005377_hearing/vestibular/ear_phenot1.67862020
41MP0006082_CNS_inflammation1.65911885
42MP0001502_abnormal_circadian_rhythm1.65815421
43MP0001835_abnormal_antigen_presentation1.65726404
44MP0009764_decreased_sensitivity_to1.64171454
45MP0009840_abnormal_foam_cell1.63779794
46MP0003195_calcinosis1.61072302
47MP0001819_abnormal_immune_cell1.60383750
48MP0009745_abnormal_behavioral_response1.60240591
49MP0002420_abnormal_adaptive_immunity1.60176144
50MP0002733_abnormal_thermal_nociception1.60146526
51MP0003303_peritoneal_inflammation1.54264714
52MP0002405_respiratory_system_inflammati1.53757528
53MP0005171_absent_coat_pigmentation1.53693513
54MP0009780_abnormal_chondrocyte_physiolo1.53380523
55MP0003436_decreased_susceptibility_to1.52746326
56MP0008469_abnormal_protein_level1.52674153
57MP0002734_abnormal_mechanical_nocicepti1.52380068
58MP0002063_abnormal_learning/memory/cond1.52009011
59MP0001501_abnormal_sleep_pattern1.51421032
60MP0009278_abnormal_bone_marrow1.47972292
61MP0005464_abnormal_platelet_physiology1.46498684
62MP0001986_abnormal_taste_sensitivity1.44678354
63MP0003011_delayed_dark_adaptation1.44557242
64MP0004947_skin_inflammation1.42390457
65MP0003448_altered_tumor_morphology1.41807533
66MP0002090_abnormal_vision1.40622921
67MP0002572_abnormal_emotion/affect_behav1.40610452
68MP0003631_nervous_system_phenotype1.40217626
69MP0005397_hematopoietic_system_phenotyp1.39730677
70MP0001545_abnormal_hematopoietic_system1.39730677
71MP0003880_abnormal_central_pattern1.39468306
72MP0001970_abnormal_pain_threshold1.39420403
73MP0009785_altered_susceptibility_to1.39363431
74MP0000920_abnormal_myelination1.38448064
75MP0006054_spinal_hemorrhage1.34995144
76MP0005365_abnormal_bile_salt1.31089992
77MP0005000_abnormal_immune_tolerance1.30151318
78MP0010155_abnormal_intestine_physiology1.29553460
79MP0000343_altered_response_to1.28826860
80MP0008569_lethality_at_weaning1.24317028
81MP0001984_abnormal_olfaction1.23531415
82MP0002067_abnormal_sensory_capabilities1.23064647
83MP0002272_abnormal_nervous_system1.20268098
84MP0003183_abnormal_peptide_metabolism1.20034409
85MP0009384_cardiac_valve_regurgitation1.17937658
86MP0003656_abnormal_erythrocyte_physiolo1.17216519
87MP0005253_abnormal_eye_physiology1.14401312
88MP0003632_abnormal_nervous_system1.13963932
89MP0004510_myositis1.13835496
90MP0005025_abnormal_response_to1.12849752
91MP0000858_altered_metastatic_potential1.10748217
92MP0009333_abnormal_splenocyte_physiolog1.07286312
93MP0005257_abnormal_intraocular_pressure1.07175237
94MP0000569_abnormal_digit_pigmentation1.06222432
95MP0000371_diluted_coat_color1.05511498
96MP0003453_abnormal_keratinocyte_physiol1.05417693
97MP0003828_pulmonary_edema1.05119497
98MP0001485_abnormal_pinna_reflex1.03403440
99MP0000716_abnormal_immune_system1.02941009
100MP0002998_abnormal_bone_remodeling1.02489791
101MP0005164_abnormal_response_to1.02384084
102MP0004883_abnormal_blood_vessel1.00418313
103MP0001533_abnormal_skeleton_physiology1.00315703
104MP0005551_abnormal_eye_electrophysiolog0.99057310
105MP0002877_abnormal_melanocyte_morpholog0.96631687
106MP0005647_abnormal_sex_gland0.93923996
107MP0004019_abnormal_vitamin_homeostasis0.92692888
108MP0005387_immune_system_phenotype0.92296443
109MP0001790_abnormal_immune_system0.92296443
110MP0005165_increased_susceptibility_to0.90792941
111MP0005645_abnormal_hypothalamus_physiol0.90393595
112MP0005310_abnormal_salivary_gland0.88830748
113MP0003724_increased_susceptibility_to0.87381947
114MP0002452_abnormal_antigen_presenting0.84908501
115MP0002557_abnormal_social/conspecific_i0.84551074
116MP0004742_abnormal_vestibular_system0.83524148
117MP0001963_abnormal_hearing_physiology0.82912784
118MP0008004_abnormal_stomach_pH0.82528693
119MP0005671_abnormal_response_to0.80480310
120MP0002229_neurodegeneration0.80084055
121MP0009763_increased_sensitivity_to0.80056342
122MP0002837_dystrophic_cardiac_calcinosis0.79929657
123MP0004924_abnormal_behavior0.78627288
124MP0005386_behavior/neurological_phenoty0.78627288
125MP0010386_abnormal_urinary_bladder0.76056546
126MP0000689_abnormal_spleen_morphology0.75825721
127MP0004142_abnormal_muscle_tone0.75240164
128MP0003795_abnormal_bone_structure0.74604035
129MP0002332_abnormal_exercise_endurance0.74511551
130MP0005595_abnormal_vascular_smooth0.74465727
131MP0000685_abnormal_immune_system0.74216771
132MP0002138_abnormal_hepatobiliary_system0.73513586
133MP0002429_abnormal_blood_cell0.73201006
134MP0005535_abnormal_body_temperature0.72912378
135MP0002882_abnormal_neuron_morphology0.72517576
136MP0002089_abnormal_postnatal_growth/wei0.69315842
137MP0004130_abnormal_muscle_cell0.68701929
138MP0008260_abnormal_autophagy0.68349042
139MP0002723_abnormal_immune_serum0.68097574
140MP0002398_abnormal_bone_marrow0.67734703
141MP0005390_skeleton_phenotype0.67201966
142MP0001663_abnormal_digestive_system0.65343095
143MP0001905_abnormal_dopamine_level0.64975839
144MP0002909_abnormal_adrenal_gland0.64369612
145MP0010307_abnormal_tumor_latency0.64054278
146MP0000465_gastrointestinal_hemorrhage0.63753892
147MP0003646_muscle_fatigue0.63308478
148MP0000249_abnormal_blood_vessel0.61851548
149MP0005319_abnormal_enzyme/_coenzyme0.59582942
150MP0009765_abnormal_xenobiotic_induced0.58971270
151MP0000609_abnormal_liver_physiology0.57700882
152MP0005584_abnormal_enzyme/coenzyme_acti0.57373998
153MP0003879_abnormal_hair_cell0.57242637
154MP0002722_abnormal_immune_system0.57217314
155MP0000015_abnormal_ear_pigmentation0.56169559

Predicted human phenotypes

RankGene SetZ-score
1Aplasia of the phalanges of the hand (HP:0009802)5.31036418
2Aplasia involving bones of the extremities (HP:0009825)5.31036418
3Aplasia involving bones of the upper limbs (HP:0009823)5.31036418
4Neurofibrillary tangles (HP:0002185)4.78288296
5Disinhibition (HP:0000734)4.71325071
6Diplopia (HP:0000651)4.61580413
7Abnormality of binocular vision (HP:0011514)4.61580413
8Recurrent abscess formation (HP:0002722)4.33448322
9Increased cerebral lipofuscin (HP:0011813)4.21532777
10Hemiparesis (HP:0001269)4.16946185
11Megalencephaly (HP:0001355)4.01259080
12Eczematoid dermatitis (HP:0000976)3.99219691
13Recurrent bacterial skin infections (HP:0005406)3.93241466
14Increased neuronal autofluorescent lipopigment (HP:0002074)3.91935518
15Mutism (HP:0002300)3.90385336
16Myocardial infarction (HP:0001658)3.80356881
17Tetraparesis (HP:0002273)3.76340061
18Recurrent gram-negative bacterial infections (HP:0005420)3.63486147
19Abnormality of the axillary hair (HP:0100134)3.62759472
20Abnormality of secondary sexual hair (HP:0009888)3.62759472
21Supranuclear gaze palsy (HP:0000605)3.53397362
22Hemiplegia (HP:0002301)3.50493434
23Abnormality of macrophages (HP:0004311)3.45295044
24Mediastinal lymphadenopathy (HP:0100721)3.43674828
25Cerebral inclusion bodies (HP:0100314)3.31946447
26Clumsiness (HP:0002312)3.22609724
27Hypoplastic left heart (HP:0004383)3.09971536
28Vacuolated lymphocytes (HP:0001922)3.07157445
29Systemic lupus erythematosus (HP:0002725)3.06731844
30Agnosia (HP:0010524)3.04947617
31Abnormality of liposaccharide metabolism (HP:0010968)3.02117029
32Abnormality of glycosphingolipid metabolism (HP:0004343)3.02117029
33Abnormality of glycolipid metabolism (HP:0010969)3.02117029
34Abnormality of the vasculature of the conjunctiva (HP:0008054)2.98772747
35Action tremor (HP:0002345)2.92928229
36Dysostosis multiplex (HP:0000943)2.87465978
37Metaphyseal irregularity (HP:0003025)2.82377146
38Inappropriate behavior (HP:0000719)2.82022468
39Focal motor seizures (HP:0011153)2.80890719
40Basal ganglia calcification (HP:0002135)2.76666001
41Stomatitis (HP:0010280)2.74628810
42Myokymia (HP:0002411)2.67833009
43Abnormality of the periventricular white matter (HP:0002518)2.65904506
44Hematochezia (HP:0002573)2.65577633
45Hepatosplenomegaly (HP:0001433)2.59911179
46Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.59236453
47Upper motor neuron abnormality (HP:0002127)2.57929774
48Neuronal loss in central nervous system (HP:0002529)2.56829670
49Onycholysis (HP:0001806)2.56106658
50Glomerulonephritis (HP:0000099)2.53162866
51Myositis (HP:0100614)2.52394434
52Purpura (HP:0000979)2.51281176
53Epileptic encephalopathy (HP:0200134)2.48239502
54Progressive cerebellar ataxia (HP:0002073)2.45639031
55Mixed hearing impairment (HP:0000410)2.44417264
56Long nose (HP:0003189)2.42739920
57Global brain atrophy (HP:0002283)2.42688673
58Progressive neurologic deterioration (HP:0002344)2.38300946
59Prostate neoplasm (HP:0100787)2.37944580
60Hypoplastic heart (HP:0001961)2.37311884
61Gingivitis (HP:0000230)2.36429100
62Generalized tonic-clonic seizures (HP:0002069)2.35711480
63Synostosis involving the elbow (HP:0003938)2.33897981
64Humeroradial synostosis (HP:0003041)2.33897981
65Adactyly (HP:0009776)2.33208087
66Xanthomatosis (HP:0000991)2.31529986
67Short middle phalanx of the 5th finger (HP:0004220)2.31469861
68Increased serum ferritin (HP:0003281)2.30681931
69Urticaria (HP:0001025)2.30072529
70Asymmetric septal hypertrophy (HP:0001670)2.26596626
71Pulmonary infiltrates (HP:0002113)2.24096796
72T lymphocytopenia (HP:0005403)2.20204923
73Potter facies (HP:0002009)2.16517087
74Facial shape deformation (HP:0011334)2.16517087
75Short hallux (HP:0010109)2.15261966
76Recurrent fungal infections (HP:0002841)2.11935731
77Autoimmune thrombocytopenia (HP:0001973)2.11660522
78Polyneuropathy (HP:0001271)2.10946983
79Peripheral demyelination (HP:0011096)2.10069034
80Recurrent skin infections (HP:0001581)2.09576763
81Dementia (HP:0000726)2.08941625
82Paraparesis (HP:0002385)2.08746311
83Hemoptysis (HP:0002105)2.08313589
84Abnormality of the middle phalanges of the toes (HP:0010183)2.07615881
85Increased CSF protein (HP:0002922)2.07206711
86Urinary glycosaminoglycan excretion (HP:0003541)2.05995242
87Mucopolysacchariduria (HP:0008155)2.05995242
88Personality changes (HP:0000751)2.05564103
89Cardiomegaly (HP:0001640)2.03012981
90Axonal loss (HP:0003447)2.02613824
91Nausea (HP:0002018)2.02493350
92Status epilepticus (HP:0002133)2.01286536
93Abnormality of nail color (HP:0100643)2.00665255
94Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)2.00015811
95Premature loss of primary teeth (HP:0006323)1.99973676
96Aplasia/Hypoplasia of the hallux (HP:0008362)1.99447528
97Amyloidosis (HP:0011034)1.99116991
98Multiple enchondromatosis (HP:0005701)1.98902001
99Poor head control (HP:0002421)1.98116062
100Progressive visual loss (HP:0000529)1.96714707
101Abnormal eating behavior (HP:0100738)1.95629746
102Retinal atrophy (HP:0001105)1.95354923
103Abnormality of T cell number (HP:0011839)1.95075377
104Prolonged neonatal jaundice (HP:0006579)1.93826876
105Protuberant abdomen (HP:0001538)1.93711378
106Abnormality of polysaccharide metabolism (HP:0011012)1.93364723
107Abnormality of glycosaminoglycan metabolism (HP:0004371)1.93364723
108Abnormality of mucopolysaccharide metabolism (HP:0011020)1.93364723
109Focal seizures (HP:0007359)1.93028649
110Pathologic fracture (HP:0002756)1.92215332
111Abnormality of iron homeostasis (HP:0011031)1.87909212
112Skin nodule (HP:0200036)1.87693595
113Postural instability (HP:0002172)1.87628596
114Abnormality of the dental pulp (HP:0006479)1.86768229
115Keratoconjunctivitis sicca (HP:0001097)1.85740229
116Craniofacial hyperostosis (HP:0004493)1.85418475
117Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.84570874
118Petechiae (HP:0000967)1.83979645
119Nuclear cataract (HP:0100018)1.83476967
120Zonular cataract (HP:0010920)1.82508105
121Spontaneous hematomas (HP:0007420)1.82359738
122Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.82040699
123Split foot (HP:0001839)1.82019015
124Obstructive lung disease (HP:0006536)1.81068014
125Chronic obstructive pulmonary disease (HP:0006510)1.81068014
126Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.80532143
127Thoracic kyphosis (HP:0002942)1.80310425
128Complement deficiency (HP:0004431)1.80222197
129Orchitis (HP:0100796)1.79105927
130Abnormality of the prostate (HP:0008775)1.78787979
131Bone pain (HP:0002653)1.78396310
132Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.77657000
133Narrow nasal bridge (HP:0000446)1.76719951
134Apathy (HP:0000741)1.75800252
135Conjunctival telangiectasia (HP:0000524)1.75479853
136Recurrent viral infections (HP:0004429)1.75448005
137Keratoconjunctivitis (HP:0001096)1.74990106
138Increased IgM level (HP:0003496)1.72880779
139Loss of speech (HP:0002371)1.72794079
140Retrobulbar optic neuritis (HP:0100654)1.72691668
141Optic neuritis (HP:0100653)1.72691668
142Dry hair (HP:0011359)1.72408356
143Malnutrition (HP:0004395)1.71972584
144Truncal ataxia (HP:0002078)1.71628508
145Dysdiadochokinesis (HP:0002075)1.71279483
146Cranial hyperostosis (HP:0004437)1.70960124
147Memory impairment (HP:0002354)1.70828488
148Albinism (HP:0001022)1.69645429
149Polyphagia (HP:0002591)1.69068608
150Abnormality of the phalanges of the 5th finger (HP:0004213)1.68973796
151Epidermoid cyst (HP:0200040)1.68146110
152Diminished motivation (HP:0000745)1.67264576
153Febrile seizures (HP:0002373)1.66684771
154Vasculitis (HP:0002633)1.65777895
155Restrictive lung disease (HP:0002091)1.65124449
156Mesangial abnormality (HP:0001966)1.64132267
157Meningitis (HP:0001287)1.63980026

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK43.90751309
2ACVR1B3.68148176
3NME23.38085098
4LMTK23.28143884
5PBK3.02150281
6EPHA42.96381215
7TGFBR22.74746547
8DDR22.66958018
9NTRK22.57337972
10PHKG22.50644043
11PHKG12.50644043
12MUSK2.45794025
13TNIK2.35830052
14NTRK32.21779493
15BLK1.96104829
16IRAK31.94842492
17MAP3K141.90770218
18TAOK21.83685001
19FGR1.75180402
20MST41.70855944
21CASK1.65259677
22PRKD31.63820215
23CAMK1D1.58204612
24ABL21.58035830
25MAP3K111.57473288
26NTRK11.53238886
27MINK11.52189975
28PDK21.51404996
29MAP3K31.38687113
30CDC42BPA1.38491393
31MAPK121.37099774
32TRIB31.36502221
33BMX1.33821907
34TAOK11.32363587
35MAP3K91.31168226
36MAP3K131.30568406
37MAP4K11.27364633
38CSF1R1.27035800
39TBK11.25782203
40ZAP701.24078513
41PIM21.22638015
42TAOK31.20005412
43SGK21.18289422
44PRKCG1.17116249
45MAP2K71.13996061
46KSR21.13300880
47MAP2K31.11043234
48MOS1.10693254
49CAMKK11.09743374
50BMPR21.03462860
51JAK11.03121631
52MATK1.03027278
53IRAK41.02895133
54NEK91.01370817
55SGK31.00629684
56DAPK21.00459246
57PRKCE1.00162745
58ARAF0.98960732
59FES0.97861833
60PAK60.97490901
61PRPF4B0.97230986
62PINK10.95709396
63SGK4940.94084101
64SGK2230.94084101
65TYK20.92758429
66GRK50.92153007
67PRKCH0.91611328
68GRK70.90923292
69CHUK0.90362917
70ADRBK10.87032329
71ERN10.84878906
72TNK20.84602594
73FGFR30.84596531
74HCK0.84562717
75MAP3K50.83773140
76CAMKK20.83340568
77JAK30.83313838
78MAP2K60.83244919
79SIK20.81673580
80LCK0.80420994
81CAMK1G0.80140044
82IRAK10.79730730
83CDK50.78888017
84BMPR1B0.77043689
85NEK60.76951394
86ERBB30.75007369
87SIK30.73751293
88IGF1R0.71139108
89MAP3K10.70975347
90MAP3K40.70606996
91EPHB10.70400027
92MAPK130.70035509
93YES10.69645013
94MARK10.69169901
95KIT0.68591834
96SIK10.68081588
97STK380.67521559
98PRKCD0.67245371
99RIPK10.67052457
100CDK60.66729680
101LYN0.66197238
102TXK0.65529904
103JAK20.62245443
104PLK20.62165592
105PDPK10.62094408
106ABL10.61060755
107CAMK2A0.60883415
108SGK10.60472934
109FYN0.58665404
110IKBKE0.57598503
111TGFBR10.57493145
112BTK0.56277188
113CSK0.55736124
114SYK0.54191387
115ADRBK20.53308085
116PDK10.53123292
117PRKCQ0.52812374
118IRAK20.52638430
119MAP3K20.52279152
120MAP3K120.51360741
121RPS6KL10.51298079
122RPS6KC10.51298079
123MAPK70.50856061
124MARK30.49607503
125SRC0.49169618
126MAP2K40.48644237
127ITK0.48282674
128TYRO30.48242918
129PRKCA0.47824224
130PRKACG0.47325964
131RPS6KA60.47099000
132ERBB40.46237579
133STK240.45852480
134IKBKB0.45623120
135RPS6KA20.45505288
136TRPM70.44799801
137LIMK10.44769579
138EGFR0.44563742
139PRKG10.44427086
140TESK20.43852146
141MAPK40.32428700
142PIM10.32247281
143PAK40.31590864
144STK100.30044554
145TEC0.29483976
146INSR0.28424894
147DYRK30.27273394
148PRKG20.26399496
149GSK3A0.24099643
150PRKAA20.22633623
151CAMK40.22299827
152FRK0.21272622
153PDGFRB0.20654815
154FER0.18090256

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.52364722
2Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.80824904
3Fatty acid biosynthesis_Homo sapiens_hsa000612.80650397
4Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.26320367
5Lysosome_Homo sapiens_hsa041421.99922365
6Nicotine addiction_Homo sapiens_hsa050331.89568559
7Antigen processing and presentation_Homo sapiens_hsa046121.87306448
8Graft-versus-host disease_Homo sapiens_hsa053321.81394667
9Staphylococcus aureus infection_Homo sapiens_hsa051501.80802572
10Malaria_Homo sapiens_hsa051441.78287542
11Rheumatoid arthritis_Homo sapiens_hsa053231.71886522
12African trypanosomiasis_Homo sapiens_hsa051431.59419171
13GABAergic synapse_Homo sapiens_hsa047271.59350478
14Mineral absorption_Homo sapiens_hsa049781.55043496
15Synaptic vesicle cycle_Homo sapiens_hsa047211.51561452
16Type I diabetes mellitus_Homo sapiens_hsa049401.50165435
17Salivary secretion_Homo sapiens_hsa049701.49930271
18Leishmaniasis_Homo sapiens_hsa051401.49914596
19Toll-like receptor signaling pathway_Homo sapiens_hsa046201.49711659
20Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.49310878
21Glutamatergic synapse_Homo sapiens_hsa047241.45372514
22Primary bile acid biosynthesis_Homo sapiens_hsa001201.44741808
23Tuberculosis_Homo sapiens_hsa051521.42748268
24Hematopoietic cell lineage_Homo sapiens_hsa046401.34114223
25Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.28747837
26RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.27917595
27Allograft rejection_Homo sapiens_hsa053301.25028202
28Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.24904967
29Gastric acid secretion_Homo sapiens_hsa049711.24849644
30Phagosome_Homo sapiens_hsa041451.19667058
31Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.19548320
32Dorso-ventral axis formation_Homo sapiens_hsa043201.16812430
33Morphine addiction_Homo sapiens_hsa050321.16694653
34Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.14113129
35Viral myocarditis_Homo sapiens_hsa054161.12419055
36Salmonella infection_Homo sapiens_hsa051321.11427126
37Pertussis_Homo sapiens_hsa051331.09215788
38Steroid biosynthesis_Homo sapiens_hsa001001.08389767
39Circadian entrainment_Homo sapiens_hsa047131.06907163
40Osteoclast differentiation_Homo sapiens_hsa043801.03103080
41Olfactory transduction_Homo sapiens_hsa047401.02238468
42Collecting duct acid secretion_Homo sapiens_hsa049661.01687953
43Insulin secretion_Homo sapiens_hsa049111.00635090
44B cell receptor signaling pathway_Homo sapiens_hsa046621.00496478
45Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.00132223
46Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.00095203
47Glycosaminoglycan degradation_Homo sapiens_hsa005310.98170554
48Carbohydrate digestion and absorption_Homo sapiens_hsa049730.95741213
49Legionellosis_Homo sapiens_hsa051340.95102499
50Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.93783298
51Fatty acid metabolism_Homo sapiens_hsa012120.93132195
52Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.91815439
53Prion diseases_Homo sapiens_hsa050200.90328352
54Other glycan degradation_Homo sapiens_hsa005110.89066794
55Bile secretion_Homo sapiens_hsa049760.88238613
56Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.88122435
57Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.86932581
58Asthma_Homo sapiens_hsa053100.86458003
59Chemokine signaling pathway_Homo sapiens_hsa040620.85811852
60Herpes simplex infection_Homo sapiens_hsa051680.85445912
61Calcium signaling pathway_Homo sapiens_hsa040200.85397447
62Vibrio cholerae infection_Homo sapiens_hsa051100.84672121
63NOD-like receptor signaling pathway_Homo sapiens_hsa046210.81429571
64Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.81420815
65Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.79676138
66Measles_Homo sapiens_hsa051620.79331261
67Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.76184400
68Jak-STAT signaling pathway_Homo sapiens_hsa046300.75209763
69Adipocytokine signaling pathway_Homo sapiens_hsa049200.74549022
70Sphingolipid signaling pathway_Homo sapiens_hsa040710.73863370
71Hepatitis C_Homo sapiens_hsa051600.72824380
72Pancreatic secretion_Homo sapiens_hsa049720.72394046
73Autoimmune thyroid disease_Homo sapiens_hsa053200.72225265
74TNF signaling pathway_Homo sapiens_hsa046680.71348783
75Long-term potentiation_Homo sapiens_hsa047200.71170059
76AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.70293314
77PPAR signaling pathway_Homo sapiens_hsa033200.69665880
78Renin secretion_Homo sapiens_hsa049240.69661620
79Apoptosis_Homo sapiens_hsa042100.68850934
80Phospholipase D signaling pathway_Homo sapiens_hsa040720.68843219
81Sulfur metabolism_Homo sapiens_hsa009200.68630474
82cAMP signaling pathway_Homo sapiens_hsa040240.68506406
83Serotonergic synapse_Homo sapiens_hsa047260.68126877
84Taste transduction_Homo sapiens_hsa047420.67187571
85Shigellosis_Homo sapiens_hsa051310.64780609
86Long-term depression_Homo sapiens_hsa047300.63745127
87Sphingolipid metabolism_Homo sapiens_hsa006000.63526995
88Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.63003174
89Cholinergic synapse_Homo sapiens_hsa047250.60838454
90Fatty acid degradation_Homo sapiens_hsa000710.60576220
91SNARE interactions in vesicular transport_Homo sapiens_hsa041300.59950237
92Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.59184885
93Tryptophan metabolism_Homo sapiens_hsa003800.58808073
94Complement and coagulation cascades_Homo sapiens_hsa046100.58659061
95Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.57562984
96Hepatitis B_Homo sapiens_hsa051610.56467860
97Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.55941924
98Bladder cancer_Homo sapiens_hsa052190.54629742
99Amoebiasis_Homo sapiens_hsa051460.53849422
100Galactose metabolism_Homo sapiens_hsa000520.53686995
101Cocaine addiction_Homo sapiens_hsa050300.52481365
102Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.52300087
103Intestinal immune network for IgA production_Homo sapiens_hsa046720.51646401
104Influenza A_Homo sapiens_hsa051640.51452763
105Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.51108213
106Thyroid hormone synthesis_Homo sapiens_hsa049180.50788723
107Circadian rhythm_Homo sapiens_hsa047100.50576699
108Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.49966154
109Fructose and mannose metabolism_Homo sapiens_hsa000510.48600731
110Toxoplasmosis_Homo sapiens_hsa051450.48060389
111Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.47919693
112NF-kappa B signaling pathway_Homo sapiens_hsa040640.47634720
113T cell receptor signaling pathway_Homo sapiens_hsa046600.46598714
114Primary immunodeficiency_Homo sapiens_hsa053400.44561052
115Renin-angiotensin system_Homo sapiens_hsa046140.42195465
116Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.41090818
117Neurotrophin signaling pathway_Homo sapiens_hsa047220.39616426
118Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.39460960
119Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.39123585
120Thyroid hormone signaling pathway_Homo sapiens_hsa049190.38903863
121GnRH signaling pathway_Homo sapiens_hsa049120.38820343
122Acute myeloid leukemia_Homo sapiens_hsa052210.38523512
123Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.38325226
124Dopaminergic synapse_Homo sapiens_hsa047280.38132675
125Prolactin signaling pathway_Homo sapiens_hsa049170.36540537
126Epstein-Barr virus infection_Homo sapiens_hsa051690.34088467
127Glutathione metabolism_Homo sapiens_hsa004800.31416564
128Leukocyte transendothelial migration_Homo sapiens_hsa046700.30918271
129HIF-1 signaling pathway_Homo sapiens_hsa040660.30138879
130Type II diabetes mellitus_Homo sapiens_hsa049300.25826207
131Platelet activation_Homo sapiens_hsa046110.24269493
132Endocytosis_Homo sapiens_hsa041440.20253467
133VEGF signaling pathway_Homo sapiens_hsa043700.15023268
134Transcriptional misregulation in cancer_Homo sapiens_hsa052020.14357713
135Systemic lupus erythematosus_Homo sapiens_hsa053220.13042294
136Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.10030693
137HTLV-I infection_Homo sapiens_hsa051660.07466649
138Insulin resistance_Homo sapiens_hsa049310.07219455
139Notch signaling pathway_Homo sapiens_hsa043300.04693727
140Arachidonic acid metabolism_Homo sapiens_hsa005900.04338127

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