PLAC1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of vascular permeability (GO:0043116)9.52032506
2branching involved in labyrinthine layer morphogenesis (GO:0060670)9.34953613
3progesterone metabolic process (GO:0042448)7.83338044
4endothelium development (GO:0003158)7.56237541
5estrogen biosynthetic process (GO:0006703)7.48909720
6C21-steroid hormone biosynthetic process (GO:0006700)7.17472386
7cAMP biosynthetic process (GO:0006171)6.91422471
8blood vessel maturation (GO:0001955)6.04764009
9basement membrane organization (GO:0071711)5.99311355
10response to follicle-stimulating hormone (GO:0032354)5.50559765
11trophectodermal cell differentiation (GO:0001829)5.42447199
12cell differentiation involved in embryonic placenta development (GO:0060706)5.39628319
13angiogenesis involved in wound healing (GO:0060055)5.30905876
14morphogenesis of an endothelium (GO:0003159)5.21618069
15endothelial tube morphogenesis (GO:0061154)5.21618069
16trophoblast giant cell differentiation (GO:0060707)5.19192695
17regulation of vascular permeability (GO:0043114)5.11096591
18G-protein coupled receptor internalization (GO:0002031)4.97115960
19regulation of gonadotropin secretion (GO:0032276)4.86794069
20positive regulation of vasodilation (GO:0045909)4.55895075
21C21-steroid hormone metabolic process (GO:0008207)4.41762842
22vasculogenesis (GO:0001570)4.11829323
23androgen biosynthetic process (GO:0006702)4.11425763
24maturation of SSU-rRNA (GO:0030490)4.04009925
25lymph vessel development (GO:0001945)4.02098108
26positive regulation of heart rate (GO:0010460)3.93416237
27mitotic metaphase plate congression (GO:0007080)3.93173560
28DNA strand elongation involved in DNA replication (GO:0006271)3.92749756
29positive regulation of male gonad development (GO:2000020)3.90698797
30glucocorticoid biosynthetic process (GO:0006704)3.90342783
31telomere maintenance via semi-conservative replication (GO:0032201)3.89796925
32cellular response to follicle-stimulating hormone stimulus (GO:0071372)3.85806015
33DNA strand elongation (GO:0022616)3.83122571
34regulation of lipoprotein metabolic process (GO:0050746)3.82348400
35wound healing, spreading of epidermal cells (GO:0035313)3.79287490
36maternal placenta development (GO:0001893)3.77265364
37sister chromatid segregation (GO:0000819)3.76129377
38embryonic heart tube development (GO:0035050)3.72606170
39keratinocyte development (GO:0003334)3.67426603
40CENP-A containing nucleosome assembly (GO:0034080)3.67180240
41DNA unwinding involved in DNA replication (GO:0006268)3.66550828
42mitotic chromosome condensation (GO:0007076)3.66372235
43ribosome assembly (GO:0042255)3.66302654
44endothelial cell morphogenesis (GO:0001886)3.62611747
45cellular response to vascular endothelial growth factor stimulus (GO:0035924)3.59676557
46positive regulation of endothelial cell differentiation (GO:0045603)3.58081855
47protein localization to kinetochore (GO:0034501)3.55119321
48pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.52040385
49chromatin remodeling at centromere (GO:0031055)3.50701755
50* placenta development (GO:0001890)3.50515169
51regulation of endothelial cell differentiation (GO:0045601)3.45773808
52negative regulation of epidermis development (GO:0045683)3.43035382
53purine nucleotide salvage (GO:0032261)3.42863119
54metaphase plate congression (GO:0051310)3.42059873
55proteasome assembly (GO:0043248)3.41819638
56cellular response to gonadotropin stimulus (GO:0071371)3.39777416
57uterus development (GO:0060065)3.39622830
58response to gonadotropin (GO:0034698)3.37713497
59bundle of His cell to Purkinje myocyte communication (GO:0086069)3.34890763
60establishment of endothelial barrier (GO:0061028)3.33696866
61protein targeting to mitochondrion (GO:0006626)3.32832733
62ribosomal small subunit biogenesis (GO:0042274)3.32764666
63nuclear pore complex assembly (GO:0051292)3.30562678
64regulation of tight junction assembly (GO:2000810)3.26871380
65nucleobase-containing small molecule interconversion (GO:0015949)3.26774824
66proline biosynthetic process (GO:0006561)3.26723178
67attachment of spindle microtubules to kinetochore (GO:0008608)3.25015534
68IMP biosynthetic process (GO:0006188)3.24419169
69nucleobase biosynthetic process (GO:0046112)3.24220588
70labyrinthine layer development (GO:0060711)3.24197961
71anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.19746429
72mitotic sister chromatid cohesion (GO:0007064)3.19571434
73telomere maintenance via recombination (GO:0000722)3.19167218
74positive regulation of odontogenesis (GO:0042482)3.17420757
75vitamin A metabolic process (GO:0006776)3.16862908
76cullin deneddylation (GO:0010388)3.16108970
77muscle cell fate commitment (GO:0042693)3.16070447
78DNA replication checkpoint (GO:0000076)3.15694654
79blood circulation (GO:0008015)3.15512577
80regulation of vasodilation (GO:0042312)3.14629986
81DNA replication initiation (GO:0006270)3.13049245
82regulation of mitochondrial translation (GO:0070129)3.12645974
83cyclic purine nucleotide metabolic process (GO:0052652)3.12089441
84kidney mesenchyme development (GO:0072074)3.11188918
85guanosine-containing compound biosynthetic process (GO:1901070)3.11025361
86pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.09567673
87regulation of cardioblast differentiation (GO:0051890)3.09508566
88mesenchymal to epithelial transition (GO:0060231)3.08083883
89interferon-gamma secretion (GO:0072643)3.08067153
90termination of RNA polymerase III transcription (GO:0006386)3.07008395
91transcription elongation from RNA polymerase III promoter (GO:0006385)3.07008395
92dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.05849427
93negative regulation of metanephros development (GO:0072217)3.04703140
94negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.03756584
95chaperone-mediated protein transport (GO:0072321)3.03734833
96pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.03276485
97regulation of translational fidelity (GO:0006450)3.02924833
98establishment of chromosome localization (GO:0051303)3.01775371
99regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.01738743
100regulation of the force of heart contraction (GO:0002026)3.01568015
101spliceosomal snRNP assembly (GO:0000387)3.00297505
102Arp2/3 complex-mediated actin nucleation (GO:0034314)3.00187915
103regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.99676854
104positive regulation of DNA-dependent DNA replication (GO:2000105)2.99632421
105establishment of integrated proviral latency (GO:0075713)2.99364839
106negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)2.99175288
107protein maturation by protein folding (GO:0022417)2.96300735
108nucleotide-excision repair, DNA gap filling (GO:0006297)2.94743921
109mitotic recombination (GO:0006312)2.94002975
110protein complex localization (GO:0031503)2.93467180
111DNA replication-dependent nucleosome organization (GO:0034723)2.93200864
112DNA replication-dependent nucleosome assembly (GO:0006335)2.93200864
113establishment of protein localization to mitochondrial membrane (GO:0090151)2.92726030
114establishment of protein localization to mitochondrion (GO:0072655)2.91195700
115spindle checkpoint (GO:0031577)2.91150160
116estrogen metabolic process (GO:0008210)2.90697560
117formation of translation preinitiation complex (GO:0001731)2.90596668
118cyclic nucleotide biosynthetic process (GO:0009190)2.90495866
119mesodermal cell differentiation (GO:0048333)2.90179612
120regulation of female gonad development (GO:2000194)2.89872236
121pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.89786175
122UTP biosynthetic process (GO:0006228)2.89477869
123protein deneddylation (GO:0000338)2.89201893
124positive regulation of heart contraction (GO:0045823)2.89141579
125galactose catabolic process (GO:0019388)2.87078878
126sprouting angiogenesis (GO:0002040)2.86275285
127pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.86065255
128positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.84473938
129histone exchange (GO:0043486)2.84270171
130DNA replication-independent nucleosome assembly (GO:0006336)2.83508742
131DNA replication-independent nucleosome organization (GO:0034724)2.83508742
132pyrimidine nucleotide catabolic process (GO:0006244)2.83106631
133cartilage morphogenesis (GO:0060536)2.83017644
134negative regulation of ligase activity (GO:0051352)2.82243171
135negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.82243171
136kinetochore organization (GO:0051383)2.82004113
137cytoskeletal anchoring at plasma membrane (GO:0007016)2.81996167
138ketone biosynthetic process (GO:0042181)2.81994407
139histone H2A monoubiquitination (GO:0035518)2.81780611
140regulation of male gonad development (GO:2000018)2.81317556
141metanephric mesenchyme development (GO:0072075)2.80440993
142negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)2.80307832
143paraxial mesoderm development (GO:0048339)2.79939619
144protein localization to mitochondrion (GO:0070585)2.79557776
145adherens junction organization (GO:0034332)2.79250883
146regulation of establishment or maintenance of cell polarity (GO:0032878)2.78974922
147mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.77006197
148IMP metabolic process (GO:0046040)2.76774594
149nuclear pore organization (GO:0006999)2.76359573
150regulation of spindle organization (GO:0090224)2.76352849
151transcription-coupled nucleotide-excision repair (GO:0006283)2.76264744
152peptidyl-histidine modification (GO:0018202)2.75617367
153blastocyst development (GO:0001824)2.75487375
154regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)2.74444753
155CTP biosynthetic process (GO:0006241)2.74224755
156CTP metabolic process (GO:0046036)2.74224755
157notochord development (GO:0030903)2.74028903
158GTP biosynthetic process (GO:0006183)2.72988212
159regulation of establishment of cell polarity (GO:2000114)2.72585082
160pteridine-containing compound biosynthetic process (GO:0042559)2.72557541
161androgen metabolic process (GO:0008209)2.70476592
162ventricular trabecula myocardium morphogenesis (GO:0003222)2.70200394
163ribosomal large subunit biogenesis (GO:0042273)2.69993544
164female pregnancy (GO:0007565)2.69454290
165phagocytosis, recognition (GO:0006910)2.69208041
166endothelial cell differentiation (GO:0045446)2.68544862
167actin nucleation (GO:0045010)2.68424666
168wound healing, spreading of cells (GO:0044319)2.65443357
169nucleoside salvage (GO:0043174)2.64135507
170blood vessel endothelial cell migration (GO:0043534)2.63011459
171regulation of lipoprotein particle clearance (GO:0010984)2.62262489
172adherens junction assembly (GO:0034333)2.61197193
173negative regulation of cell cycle G2/M phase transition (GO:1902750)2.61088856
174mitotic sister chromatid segregation (GO:0000070)2.60374240
175pore complex assembly (GO:0046931)2.60334963
176low-density lipoprotein particle clearance (GO:0034383)2.59260336
177endothelial cell proliferation (GO:0001935)2.59011098
178regulation of G0 to G1 transition (GO:0070316)2.58397065
179purine nucleobase biosynthetic process (GO:0009113)2.57719216
180substrate adhesion-dependent cell spreading (GO:0034446)2.57177860
181protein localization to chromosome, centromeric region (GO:0071459)2.53593908
182Notch signaling involved in heart development (GO:0061314)2.52932917
183receptor internalization (GO:0031623)2.52415441
184regulation of mammary gland epithelial cell proliferation (GO:0033599)2.51208992
185vascular endothelial growth factor signaling pathway (GO:0038084)2.51128942
186mitotic cytokinesis (GO:0000281)2.50945719
187heart trabecula morphogenesis (GO:0061384)2.48882641
188hormone catabolic process (GO:0042447)2.48184888
189positive regulation of cell size (GO:0045793)2.47854236
190doxorubicin metabolic process (GO:0044598)2.45461805
191positive regulation of vasculogenesis (GO:2001214)14.1167487
192regulation of vasculogenesis (GO:2001212)10.4804427

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.51125012
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.26030762
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.22042197
4TP63_17297297_ChIP-ChIP_HaCaT_Human3.91344181
5HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.56883863
6RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.37566698
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.27356656
8HIF1A_21447827_ChIP-Seq_MCF-7_Human3.20940714
9GABP_17652178_ChIP-ChIP_JURKAT_Human2.86042684
10KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.82093355
11KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.82093355
12KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.82093355
13ETS1_20019798_ChIP-Seq_JURKAT_Human2.80615730
14POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.63385160
15NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.62241602
16AR_21909140_ChIP-Seq_LNCAP_Human2.59791425
17NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.59314532
18THAP11_20581084_ChIP-Seq_MESCs_Mouse2.54349409
19ELK3_25401928_ChIP-Seq_HUVEC_Human2.52892764
20DCP1A_22483619_ChIP-Seq_HELA_Human2.51947879
21EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.50207005
22MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.45328327
23ZNF263_19887448_ChIP-Seq_K562_Human2.41667073
24KLF4_18358816_ChIP-ChIP_MESCs_Mouse2.39592646
25FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.37955581
26PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.34374385
27MYC_18555785_ChIP-Seq_MESCs_Mouse2.29769981
28SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse2.09577527
29EOMES_20176728_ChIP-ChIP_TSCs_Mouse2.07327750
30TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.03831100
31STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.00708912
32FOXM1_23109430_ChIP-Seq_U2OS_Human1.98180183
33CLOCK_20551151_ChIP-Seq_293T_Human1.96667449
34FOXP3_21729870_ChIP-Seq_TREG_Human1.93802094
35TCF3_18692474_ChIP-Seq_MEFs_Mouse1.87608450
36TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.86923373
37EGR1_19374776_ChIP-ChIP_THP-1_Human1.86620029
38VDR_23849224_ChIP-Seq_CD4+_Human1.84548971
39TP63_19390658_ChIP-ChIP_HaCaT_Human1.81414118
40E2F4_17652178_ChIP-ChIP_JURKAT_Human1.80940793
41HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.80866087
42FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.75392123
43MYCN_18555785_ChIP-Seq_MESCs_Mouse1.74899421
44NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.74896486
45ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.74127338
46SRF_21415370_ChIP-Seq_HL-1_Mouse1.71807780
47YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.71774237
48GATA2_21666600_ChIP-Seq_HMVEC_Human1.71001135
49PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.70873876
50FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.68977376
51ELK1_19687146_ChIP-ChIP_HELA_Human1.68431747
52KDM5A_27292631_Chip-Seq_BREAST_Human1.68023644
53MYC_19079543_ChIP-ChIP_MESCs_Mouse1.66464073
54ZFP281_18757296_ChIP-ChIP_E14_Mouse1.65017644
55MYC_22102868_ChIP-Seq_BL_Human1.60888319
56MYC_19030024_ChIP-ChIP_MESCs_Mouse1.58668438
57NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.57736702
58SALL4_18804426_ChIP-ChIP_XEN_Mouse1.57608277
59KLF4_18555785_ChIP-Seq_MESCs_Mouse1.55921395
60CDX2_20551321_ChIP-Seq_CACO-2_Human1.54316814
61PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.53832598
62MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.52659759
63HOXB4_20404135_ChIP-ChIP_EML_Mouse1.52496025
64ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.52226667
65ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.50831594
66PADI4_21655091_ChIP-ChIP_MCF-7_Human1.49927608
67STAT3_1855785_ChIP-Seq_MESCs_Mouse1.48538526
68ESR1_15608294_ChIP-ChIP_MCF-7_Human1.45808785
69CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.44779137
70ATF3_27146783_Chip-Seq_COLON_Human1.44498379
71OCT4_18692474_ChIP-Seq_MEFs_Mouse1.43856958
72XRN2_22483619_ChIP-Seq_HELA_Human1.42668391
73NELFA_20434984_ChIP-Seq_ESCs_Mouse1.42270292
74MYC_18358816_ChIP-ChIP_MESCs_Mouse1.41216633
75E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.40280515
76RACK7_27058665_Chip-Seq_MCF-7_Human1.38558966
77KDM2B_26808549_Chip-Seq_SUP-B15_Human1.37558376
78SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.37350248
79ELF1_17652178_ChIP-ChIP_JURKAT_Human1.35402963
80CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.34898941
81SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.34463070
82ERG_20887958_ChIP-Seq_HPC-7_Mouse1.34087093
83RARG_19884340_ChIP-ChIP_MEFs_Mouse1.32573340
84HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.30774260
85TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.30539517
86KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.29157355
87DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.28977920
88KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.28760730
89POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.27971535
90KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.25475863
91CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.24863544
92MYC_18940864_ChIP-ChIP_HL60_Human1.21944748
93SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.21796118
94NCOR1_26117541_ChIP-Seq_K562_Human1.21727215
95CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.21466733
96NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.20195129
97CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.18652320
98MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.18123091
99CREB1_15753290_ChIP-ChIP_HEK293T_Human1.18120776
100E2F1_18555785_ChIP-Seq_MESCs_Mouse1.17979219
101KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.16238714
102NANOG_18555785_ChIP-Seq_MESCs_Mouse1.14922086
103CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.14568393
104BP1_19119308_ChIP-ChIP_Hs578T_Human1.14042533
105RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.13531279
106YY1_21170310_ChIP-Seq_MESCs_Mouse1.13335776
107TCF3_18692474_ChIP-Seq_MESCs_Mouse1.11955316
108POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.10276007
109ZFX_18555785_ChIP-Seq_MESCs_Mouse1.08407263
110SCL_19346495_ChIP-Seq_HPC-7_Human1.06280387
111KDM2B_26808549_Chip-Seq_K562_Human1.06123327
112PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.04871488
113SOX2_18692474_ChIP-Seq_MEFs_Mouse1.04868016
114ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.04220602
115CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.04132266
116TCF7_22412390_ChIP-Seq_EML_Mouse1.04101836
117SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.03339508
118KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.03060132
119CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.02732544
120GABP_19822575_ChIP-Seq_HepG2_Human1.02696551
121TTF2_22483619_ChIP-Seq_HELA_Human1.01877158
122TFEB_21752829_ChIP-Seq_HELA_Human1.01003991
123GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.00833487
124SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.00326819
125SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.00326819
126TBX5_21415370_ChIP-Seq_HL-1_Mouse0.99008667
127HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.98375837
128SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.98091489
129* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.95910219
130TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.95803419
131SOX17_20123909_ChIP-Seq_XEN_Mouse0.95554120
132SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.94744540
133BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.94528340
134KDM2B_26808549_Chip-Seq_DND41_Human0.93724474
135* CHD1_26751641_Chip-Seq_LNCaP_Human0.93222595
136DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.92012649
137NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.91724608
138BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.91645234
139PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.91621332
140GATA6_25053715_ChIP-Seq_YYC3_Human0.91430556
141ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.91415293
142MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.90599827
143ELK1_22589737_ChIP-Seq_MCF10A_Human0.90389600
144FOXO3_23340844_ChIP-Seq_DLD1_Human0.90375849
145E2F1_21310950_ChIP-Seq_MCF-7_Human0.89234399
146TP53_22127205_ChIP-Seq_IMR90_Human0.89094329
147STAT6_21828071_ChIP-Seq_BEAS2B_Human0.88906181
148LXR_22292898_ChIP-Seq_THP-1_Human0.88543853
149CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.88324138
150SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.88240233
151TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.87532274
152EST1_17652178_ChIP-ChIP_JURKAT_Human0.86278666
153WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.85822080
154ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.85755476
155CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.85672586
156NOTCH1_21737748_ChIP-Seq_TLL_Human0.85233701
157TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.84403098
158PKCTHETA_26484144_Chip-Seq_BREAST_Human0.81520498
159CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.79812029
160NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.79708262
161SOX2_18555785_ChIP-Seq_MESCs_Mouse0.77793505
162SRY_22984422_ChIP-ChIP_TESTIS_Rat0.77227196
163TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.75259265

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005167_abnormal_blood-brain_barrier5.58905464
2MP0003122_maternal_imprinting5.50721657
3MP0004272_abnormal_basement_membrane5.06045897
4MP0003123_paternal_imprinting4.76088802
5MP0003705_abnormal_hypodermis_morpholog4.66746397
6MP0003121_genomic_imprinting4.31944120
7MP0004264_abnormal_extraembryonic_tissu4.25921467
8MP0008995_early_reproductive_senescence3.99910729
9MP0010368_abnormal_lymphatic_system3.81562799
10MP0003941_abnormal_skin_development3.79235660
11MP0010094_abnormal_chromosome_stability3.29451514
12MP0003786_premature_aging3.20895997
13MP0001879_abnormal_lymphatic_vessel3.19401723
14MP0003787_abnormal_imprinting2.82720875
15MP0008058_abnormal_DNA_repair2.60130875
16MP0006054_spinal_hemorrhage2.58820333
17MP0002160_abnormal_reproductive_system2.50515059
18MP0010352_gastrointestinal_tract_polyps2.43852398
19MP0002086_abnormal_extraembryonic_tissu2.30525726
20MP0003221_abnormal_cardiomyocyte_apopto2.28498447
21MP0001919_abnormal_reproductive_system2.27314889
22MP0005389_reproductive_system_phenotype2.24017818
23MP0003718_maternal_effect2.21348025
24MP0002295_abnormal_pulmonary_circulatio2.03020967
25MP0001661_extended_life_span2.01629639
26MP0000639_abnormal_adrenal_gland1.86758850
27MP0005023_abnormal_wound_healing1.82954339
28MP0003566_abnormal_cell_adhesion1.81683584
29MP0000013_abnormal_adipose_tissue1.81020051
30MP0004084_abnormal_cardiac_muscle1.80936591
31MP0002127_abnormal_cardiovascular_syste1.80117685
32MP0003984_embryonic_growth_retardation1.79694727
33MP0000249_abnormal_blood_vessel1.75984963
34MP0002088_abnormal_embryonic_growth/wei1.75958795
35MP0003186_abnormal_redox_activity1.74871840
36MP0003567_abnormal_fetal_cardiomyocyte1.71404883
37MP0005623_abnormal_meninges_morphology1.69072911
38MP0010030_abnormal_orbit_morphology1.67973852
39MP0004957_abnormal_blastocyst_morpholog1.66270332
40MP0000465_gastrointestinal_hemorrhage1.64441697
41MP0005380_embryogenesis_phenotype1.64378741
42MP0001672_abnormal_embryogenesis/_devel1.64378741
43MP0004197_abnormal_fetal_growth/weight/1.63363459
44MP0003942_abnormal_urinary_system1.63052445
45MP0001727_abnormal_embryo_implantation1.53754247
46MP0002210_abnormal_sex_determination1.52113807
47MP0001346_abnormal_lacrimal_gland1.51228577
48MP0005379_endocrine/exocrine_gland_phen1.47245670
49MP0002925_abnormal_cardiovascular_devel1.46949020
50MP0008775_abnormal_heart_ventricle1.46201106
51MP0005647_abnormal_sex_gland1.41022138
52MP0001697_abnormal_embryo_size1.40780330
53MP0003936_abnormal_reproductive_system1.36821905
54MP0001730_embryonic_growth_arrest1.36221700
55MP0010307_abnormal_tumor_latency1.35098035
56MP0003119_abnormal_digestive_system1.33770236
57MP0006036_abnormal_mitochondrial_physio1.29582328
58MP0001145_abnormal_male_reproductive1.28833218
59MP0001929_abnormal_gametogenesis1.24074766
60MP0000767_abnormal_smooth_muscle1.22911428
61MP0003385_abnormal_body_wall1.21414400
62MP0000653_abnormal_sex_gland1.19811233
63MP0003806_abnormal_nucleotide_metabolis1.19792053
64MP0000537_abnormal_urethra_morphology1.18899376
65MP0009697_abnormal_copulation1.17433834
66MP0002128_abnormal_blood_circulation1.11168794
67MP0003279_aneurysm1.09685071
68MP0003693_abnormal_embryo_hatching1.08688297
69MP0002163_abnormal_gland_morphology1.07511954
70MP0000678_abnormal_parathyroid_gland1.07311873
71MP0000383_abnormal_hair_follicle1.06931230
72MP0000003_abnormal_adipose_tissue1.06809870
73MP0001614_abnormal_blood_vessel1.06164867
74MP0000313_abnormal_cell_death1.05040708
75MP0006035_abnormal_mitochondrial_morpho1.03157701
76MP0002080_prenatal_lethality1.02681817
77MP0004858_abnormal_nervous_system1.02172435
78MP0001119_abnormal_female_reproductive0.98467116
79MP0009672_abnormal_birth_weight0.96954812
80MP0003091_abnormal_cell_migration0.96651419
81MP0000762_abnormal_tongue_morphology0.95516852
82MP0002084_abnormal_developmental_patter0.95340993
83MP0008007_abnormal_cellular_replicative0.93985696
84MP0009333_abnormal_splenocyte_physiolog0.93973770
85MP0001784_abnormal_fluid_regulation0.92675781
86MP0001915_intracranial_hemorrhage0.92153679
87MP0003315_abnormal_perineum_morphology0.92102987
88MP0003699_abnormal_female_reproductive0.90842910
89MP0005410_abnormal_fertilization0.88994769
90MP0010678_abnormal_skin_adnexa0.88770714
91MP0002972_abnormal_cardiac_muscle0.88754854
92MP0005395_other_phenotype0.88054889
93MP0009384_cardiac_valve_regurgitation0.87649218
94MP0000749_muscle_degeneration0.87590207
95MP0003077_abnormal_cell_cycle0.87532454
96MP0002234_abnormal_pharynx_morphology0.86829047
97MP0004883_abnormal_blood_vessel0.86193777
98MP0004233_abnormal_muscle_weight0.85219158
99MP0005330_cardiomyopathy0.84923071
100MP0000266_abnormal_heart_morphology0.84277539
101MP0000358_abnormal_cell_content/0.83742287
102MP0005408_hypopigmentation0.82965470
103MP0000350_abnormal_cell_proliferation0.82892815
104MP0010630_abnormal_cardiac_muscle0.82760673
105MP0001544_abnormal_cardiovascular_syste0.82705668
106MP0005385_cardiovascular_system_phenoty0.82705668
107MP0002085_abnormal_embryonic_tissue0.82163663
108MP0001764_abnormal_homeostasis0.80984243
109MP0003111_abnormal_nucleus_morphology0.79608561
110MP0003183_abnormal_peptide_metabolism0.78120915
111MP0008877_abnormal_DNA_methylation0.77926080
112MP0002332_abnormal_exercise_endurance0.77226038
113MP0006138_congestive_heart_failure0.76789075
114MP0003890_abnormal_embryonic-extraembry0.76659081
115MP0001756_abnormal_urination0.76126012
116MP0003453_abnormal_keratinocyte_physiol0.75466183
117MP0005646_abnormal_pituitary_gland0.75146561
118MP0004085_abnormal_heartbeat0.75129242
119MP0008932_abnormal_embryonic_tissue0.74195947
120MP0000343_altered_response_to0.73786731
121MP0004510_myositis0.73173643
122MP0002249_abnormal_larynx_morphology0.72844110
123MP0000230_abnormal_systemic_arterial0.72797843
124MP0009780_abnormal_chondrocyte_physiolo0.72755177
125MP0003698_abnormal_male_reproductive0.72324014
126MP0008770_decreased_survivor_rate0.70546259
127MP0002132_abnormal_respiratory_system0.69984251
128MP0005220_abnormal_exocrine_pancreas0.69821785
129MP0000049_abnormal_middle_ear0.69341131
130MP0003943_abnormal_hepatobiliary_system0.69162538
131MP0002796_impaired_skin_barrier0.67436724
132MP0005187_abnormal_penis_morphology0.67409036
133MP0002161_abnormal_fertility/fecundity0.66881648
134MP0003115_abnormal_respiratory_system0.66387856
135MP0008057_abnormal_DNA_replication0.66266732
136MP0001881_abnormal_mammary_gland0.64997844
137MP0009703_decreased_birth_body0.63798538
138MP0002177_abnormal_outer_ear0.62938105
139MP0009379_abnormal_foot_pigmentation0.62456557
140MP0002938_white_spotting0.61962973
141MP0002697_abnormal_eye_size0.61542141
142MP0005595_abnormal_vascular_smooth0.61459958
143MP0003828_pulmonary_edema0.61272190
144MP0000733_abnormal_muscle_development0.61224312
145MP0001293_anophthalmia0.61136547
146MP0002114_abnormal_axial_skeleton0.59377131
147MP0005501_abnormal_skin_physiology0.59177347
148MP0005620_abnormal_muscle_contractility0.58734761
149MP0002396_abnormal_hematopoietic_system0.58591172
150MP0005257_abnormal_intraocular_pressure0.58328708
151MP0004036_abnormal_muscle_relaxation0.57957333
152MP0004782_abnormal_surfactant_physiolog0.55558755
153MP0002254_reproductive_system_inflammat0.55355275
154MP0002877_abnormal_melanocyte_morpholog0.52461980
155MP0003937_abnormal_limbs/digits/tail_de0.52036614
156MP0003011_delayed_dark_adaptation0.51218258
157MP0003448_altered_tumor_morphology0.50918516
158MP0005367_renal/urinary_system_phenotyp0.50664230
159MP0000516_abnormal_urinary_system0.50664230
160MP0005164_abnormal_response_to0.49250555
161MP0002269_muscular_atrophy0.49104507

Predicted human phenotypes

RankGene SetZ-score
1Hepatoblastoma (HP:0002884)5.95406499
2Asymmetry of the thorax (HP:0001555)5.22342953
3Diastasis recti (HP:0001540)5.04595940
4Gonadal dysgenesis (HP:0000133)5.01331617
5Degeneration of anterior horn cells (HP:0002398)4.75891204
6Abnormality of the anterior horn cell (HP:0006802)4.75891204
7Hypoplastic left heart (HP:0004383)4.66539005
8Testicular neoplasm (HP:0010788)4.52690649
9Septate vagina (HP:0001153)4.20969808
10Diaphragmatic weakness (HP:0009113)4.04848222
11Nephroblastoma (Wilms tumor) (HP:0002667)3.85487881
12Spontaneous hematomas (HP:0007420)3.83694690
13Multiple enchondromatosis (HP:0005701)3.80167841
14Transposition of the great arteries (HP:0001669)3.69399681
15Abnormal connection of the cardiac segments (HP:0011545)3.69399681
16Abnormal ventriculo-arterial connection (HP:0011563)3.69399681
17Hypoplastic heart (HP:0001961)3.68173411
18Metaphyseal dysplasia (HP:0100255)3.65903775
19Embryonal renal neoplasm (HP:0011794)3.57838190
20Male infertility (HP:0003251)3.54302414
21Stridor (HP:0010307)3.54290059
22Right ventricular cardiomyopathy (HP:0011663)3.44717114
23Abnormal sex determination (HP:0012244)3.41788959
24Sex reversal (HP:0012245)3.41788959
25Short 5th finger (HP:0009237)3.40259372
26Selective tooth agenesis (HP:0001592)3.27615777
27Esophageal varix (HP:0002040)3.20986084
28Female pseudohermaphroditism (HP:0010458)3.17225268
29Polycythemia (HP:0001901)3.14606203
30Aplasia/Hypoplasia of the 5th finger (HP:0006262)3.09784033
31Increased connective tissue (HP:0009025)3.07689090
32Lymphangioma (HP:0100764)2.99704400
33Tongue fasciculations (HP:0001308)2.94085868
34Bilateral microphthalmos (HP:0007633)2.89407314
35Periauricular skin pits (HP:0100277)2.88723519
36Preauricular pit (HP:0004467)2.88723519
37Chromosomal breakage induced by crosslinking agents (HP:0003221)2.87379860
38Abnormal pancreas size (HP:0012094)2.86424052
39Micronodular cirrhosis (HP:0001413)2.86257710
40Purpura (HP:0000979)2.84384411
41Abnormal tarsal ossification (HP:0008369)2.82425849
42Proximal placement of thumb (HP:0009623)2.80022022
43Abnormality of the umbilical cord (HP:0010881)2.78683658
44Abnormality of the fetal cardiovascular system (HP:0010948)2.74128310
45Abnormal umbilical cord blood vessels (HP:0011403)2.74128310
46Single umbilical artery (HP:0001195)2.74128310
47Neoplasm of the adrenal cortex (HP:0100641)2.72070175
48Reduced antithrombin III activity (HP:0001976)2.72055635
49Male pseudohermaphroditism (HP:0000037)2.69722792
50Increased variability in muscle fiber diameter (HP:0003557)2.69466033
51Abnormality of skeletal muscle fiber size (HP:0012084)2.69111139
52Chromsome breakage (HP:0040012)2.67145060
53Petechiae (HP:0000967)2.61876302
54Deep venous thrombosis (HP:0002625)2.56104807
55Pili torti (HP:0003777)2.56030419
56Hematochezia (HP:0002573)2.53160675
57Capillary hemangiomas (HP:0005306)2.52516627
58Abnormality of glycolysis (HP:0004366)2.52498275
59Acute encephalopathy (HP:0006846)2.52402165
60Curly hair (HP:0002212)2.50941813
61Secondary amenorrhea (HP:0000869)2.49761967
62Small epiphyses (HP:0010585)2.46950833
63Increased mean platelet volume (HP:0011877)2.46014627
64Renal duplication (HP:0000075)2.44563400
65Abnormal foot bone ossification (HP:0010675)2.43607816
66Dry hair (HP:0011359)2.42793911
67Premature ovarian failure (HP:0008209)2.42147707
68Hypergonadotropic hypogonadism (HP:0000815)2.41396790
69Microretrognathia (HP:0000308)2.41001504
70Spinal cord compression (HP:0002176)2.40206339
71Abnormal mitochondria in muscle tissue (HP:0008316)2.39704916
72Visceral angiomatosis (HP:0100761)2.38504677
73Spinal muscular atrophy (HP:0007269)2.38272260
74Acute necrotizing encephalopathy (HP:0006965)2.34718257
75Adrenal hypoplasia (HP:0000835)2.32954891
7611 pairs of ribs (HP:0000878)2.32236252
77Increased serum pyruvate (HP:0003542)2.32205969
78Abnormal platelet volume (HP:0011876)2.32053950
79Missing ribs (HP:0000921)2.31866836
80Hemangiomatosis (HP:0007461)2.31645844
81Preauricular skin tag (HP:0000384)2.29352704
82Muscle fibrillation (HP:0010546)2.26016603
83Germ cell neoplasia (HP:0100728)2.25798718
84Abnormal gallbladder physiology (HP:0012438)2.24608395
85Cholecystitis (HP:0001082)2.24608395
86Anomalous pulmonary venous return (HP:0010772)2.23688642
87Hypotrichosis (HP:0001006)2.21422453
88Aplastic anemia (HP:0001915)2.21172742
89Epiphyseal dysplasia (HP:0002656)2.20544438
90Aplasia/hypoplasia of the humerus (HP:0006507)2.19011756
91Meckel diverticulum (HP:0002245)2.16798593
92Short humerus (HP:0005792)2.16243863
93Gout (HP:0001997)2.15703311
94Abnormality of the distal phalanx of the thumb (HP:0009617)2.14707285
95Abnormality of the preputium (HP:0100587)2.14009002
96Decreased activity of mitochondrial respiratory chain (HP:0008972)2.13729575
97Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.13729575
98Ragged-red muscle fibers (HP:0003200)2.13716850
99Mesangial abnormality (HP:0001966)2.11660229
100Abnormality of the phalanges of the hallux (HP:0010057)2.11625302
101Glossoptosis (HP:0000162)2.10203262
102Neonatal hypoglycemia (HP:0001998)2.09238524
103Macrocytic anemia (HP:0001972)2.07367571
104Conjunctival telangiectasia (HP:0000524)2.06480797
105Apathy (HP:0000741)2.06466171
106Rib fusion (HP:0000902)2.05858750
107Testicular atrophy (HP:0000029)2.05344085
108Megalocornea (HP:0000485)2.03916597
109Volvulus (HP:0002580)2.03160718
110Abnormality of the ileum (HP:0001549)2.02628465
111Microvesicular hepatic steatosis (HP:0001414)2.01730252
112Skin tags (HP:0010609)2.01272953
113Difficulty running (HP:0009046)2.01246888
114Abnormalities of placenta or umbilical cord (HP:0001194)2.01077717
115Deviation of the thumb (HP:0009603)2.00966079
116Woolly hair (HP:0002224)2.00365623
117Slender long bone (HP:0003100)2.00212080
118Overgrowth (HP:0001548)1.97319280
119Fused cervical vertebrae (HP:0002949)1.96928147
120Trismus (HP:0000211)1.96889283
121Sparse eyelashes (HP:0000653)1.95913988
122Abnormality of the intrinsic pathway (HP:0010989)1.95839581
123Reduced subcutaneous adipose tissue (HP:0003758)1.95666121
124Increased nuchal translucency (HP:0010880)1.95036770
125Atrophy/Degeneration involving motor neurons (HP:0007373)1.94996412
126Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.94754134
127Aplasia/Hypoplasia of the sacrum (HP:0008517)1.94608721
128Abnormality of the calcaneus (HP:0008364)1.94517191
129Short 4th metacarpal (HP:0010044)1.94439536
130Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.94439536
131Skin pits (HP:0100276)1.94252084
132Paralysis (HP:0003470)1.94010639
133Nonimmune hydrops fetalis (HP:0001790)1.93695762
134Abnormal lung lobation (HP:0002101)1.93493291
135Hypochromic microcytic anemia (HP:0004840)1.93304012
136Lip pit (HP:0100267)1.93166083
137Radial bowing (HP:0002986)1.92853108
138Megaloblastic anemia (HP:0001889)1.92617176
139Birth length less than 3rd percentile (HP:0003561)1.92496567
140Facial cleft (HP:0002006)1.91680246
141Increased CSF lactate (HP:0002490)1.91065032
142Lymphedema (HP:0001004)1.90466528
143Increased serum lactate (HP:0002151)1.90386561
144Achilles tendon contracture (HP:0001771)1.90085358
145Abnormality of the pulmonary veins (HP:0011718)1.90056210
146Sensory axonal neuropathy (HP:0003390)1.89916600
147Skull defect (HP:0001362)1.89546482
148Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.89236517
149Degeneration of the lateral corticospinal tracts (HP:0002314)1.89236517
150Abnormality of the lower motor neuron (HP:0002366)1.88820551
151Sprengel anomaly (HP:0000912)1.88334240
152EMG: myopathic abnormalities (HP:0003458)1.88242939
153Hyperacusis (HP:0010780)1.86335140
154Neonatal death (HP:0003811)1.86239469
155Abnormality of the distal phalanges of the toes (HP:0010182)1.84907666
156Progressive muscle weakness (HP:0003323)1.83373759
157Mitochondrial inheritance (HP:0001427)1.83243834
158Nausea (HP:0002018)1.82961044
159Ventricular tachycardia (HP:0004756)1.82376195
160Webbed neck (HP:0000465)1.82061257
161Hyperglycinemia (HP:0002154)1.81850346
162Difficulty climbing stairs (HP:0003551)1.80425744
163Intestinal polyp (HP:0005266)1.79846000
164Bifid tongue (HP:0010297)1.79416827
165Reticulocytopenia (HP:0001896)1.78332087
166Intestinal polyposis (HP:0200008)1.78121684
167Thin bony cortex (HP:0002753)1.77598674
168Bilateral sensorineural hearing impairment (HP:0008619)1.76246759
169Diminished motivation (HP:0000745)1.75632833
170Hypoplastic pelvis (HP:0008839)1.74808386
171Angiofibromas (HP:0010615)1.74430790
172Adenoma sebaceum (HP:0009720)1.74430790
173Abnormal pupillary function (HP:0007686)1.74370230
174Fasciculations (HP:0002380)1.74324027
175Deviation of the hallux (HP:0010051)1.73583947
176Submucous cleft hard palate (HP:0000176)1.73380603
177Progressive macrocephaly (HP:0004481)1.73375629
178Abnormal cartilage morphology (HP:0002763)1.72340780
179Renal Fanconi syndrome (HP:0001994)1.70556731
180Small intestinal stenosis (HP:0012848)1.70370446
181Duodenal stenosis (HP:0100867)1.70370446
182Abnormal auditory evoked potentials (HP:0006958)1.69999859
183Carpal bone hypoplasia (HP:0001498)1.68992601
184Aplasia/Hypoplasia of the uvula (HP:0010293)1.68255460

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PLK46.09542268
2KDR4.19770269
3PKN24.07088092
4EIF2AK34.01210253
5TIE13.27463395
6STK103.24928620
7TRIB33.22473176
8CDK123.02032592
9ERN12.98670624
10GRK12.95179567
11SRPK12.86695903
12PRKG22.39555312
13PBK2.37651822
14VRK22.31811271
15LIMK12.26718706
16EIF2AK12.23962923
17WEE12.20815037
18EPHA22.19327874
19MST42.13119929
20STK162.06752717
21STK391.97487014
22TGFBR11.87337490
23TGFBR21.85142039
24LATS21.81181234
25NME11.76493892
26LRRK21.74393202
27MAP3K121.62961190
28PDK21.55969767
29PTK2B1.55210519
30ZAK1.55054747
31BRSK11.50158726
32IRAK31.48625231
33GRK51.45936340
34TSSK61.45359038
35PTK61.44883668
36RIPK11.43415397
37MAP2K31.43074849
38MAP3K111.41024186
39FER1.40245217
40TYRO31.39839688
41PTK21.34364313
42BRAF1.34191714
43EEF2K1.32122121
44TLK11.31139710
45OXSR11.29087486
46CCNB11.28593712
47MAP3K81.27761989
48PAK41.25287390
49MST1R1.24959198
50SMG11.22028091
51SIK31.19363532
52CDK71.18620712
53VRK11.15366860
54MOS1.13418126
55ATR1.11071046
56ALK1.08702789
57TRIM281.08190494
58BUB11.07377881
59CHEK21.06206451
60RPS6KB21.05689211
61MAP3K31.02108670
62PNCK1.01284896
63TTK0.99858012
64AKT30.94053760
65CHEK10.94016212
66MARK30.92408401
67TAF10.90115668
68ADRBK20.87980997
69STK40.86908129
70CDK80.86804621
71ERBB30.86500814
72PLK20.85977552
73MAP3K100.85422965
74GRK60.83117489
75NEK10.80624090
76EPHB20.77928893
77MAPK120.72995388
78MAPK70.72658588
79PRKD30.71908676
80NEK20.69194117
81CDC70.68438652
82PAK10.67459232
83BRSK20.67403652
84CSNK1G30.67026982
85PAK20.66356281
86CSF1R0.65347248
87NME20.62237117
88AKT20.62186158
89DAPK10.61916847
90MATK0.61143213
91ROCK20.60119609
92ICK0.59301374
93PLK10.58216061
94MAP2K20.57558816
95MAP3K10.56332176
96BMPR20.55026652
97ARAF0.54660346
98CSNK1G10.53630027
99TAOK20.52724596
100FRK0.52033806
101BCR0.50215904
102RPS6KA50.49804123
103CSNK2A20.49397076
104ATM0.49120974
105MET0.48891766
106ADRBK10.47019310
107ILK0.46782291
108CSNK1A1L0.46729024
109CSNK2A10.46370952
110MYLK0.45823854
111CDK10.44454095
112MAP3K90.44422112
113CDK40.44204252
114CDK20.43397442
115DMPK0.42314083
116BRD40.41756353
117AURKA0.41749352
118CSK0.41695631
119PIM20.41118082
120CDK140.39248237
121IGF1R0.38438988
122TESK20.37844401
123PDK10.37754485
124NEK60.37654532
125TESK10.37637502
126RET0.37473849
127MTOR0.36534635
128MAP2K10.36040783
129MELK0.34874262
130PLK30.34350860
131MAP2K40.33958094
132SCYL20.33526113
133ABL20.32653502
134SRC0.32059347
135CLK10.31798898
136MAPKAPK20.30729094
137SIK10.30630976
138PDGFRA0.30325317
139IRAK20.29876816
140PAK30.28283219
141AURKB0.28282377
142ERBB40.28017206
143PDPK10.27854691
144ROCK10.27791734
145EIF2AK20.27164203
146PASK0.26793876
147CAMKK10.26690901
148PRKCI0.26111070
149EGFR0.25073909
150DAPK30.24742667
151FGFR10.24683929
152CDK90.24312484
153CDK150.23502599
154CDK11A0.22940034
155CDK180.22606131
156PRKD10.22545737
157RPS6KA40.22346472

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034303.66474745
2Pathogenic Escherichia coli infection_Homo sapiens_hsa051302.96665271
3Bacterial invasion of epithelial cells_Homo sapiens_hsa051002.92719242
4Base excision repair_Homo sapiens_hsa034102.84120833
5Leukocyte transendothelial migration_Homo sapiens_hsa046702.73530103
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.62651861
7Cell cycle_Homo sapiens_hsa041102.21207924
8RNA transport_Homo sapiens_hsa030132.12539879
9Fatty acid elongation_Homo sapiens_hsa000622.12493120
10Homologous recombination_Homo sapiens_hsa034402.08996741
11Tight junction_Homo sapiens_hsa045302.08507440
12Thyroid cancer_Homo sapiens_hsa052162.03944584
13Sulfur relay system_Homo sapiens_hsa041222.00884889
14Linoleic acid metabolism_Homo sapiens_hsa005912.00474292
15Folate biosynthesis_Homo sapiens_hsa007901.98772652
16Galactose metabolism_Homo sapiens_hsa000521.94754513
17Oxidative phosphorylation_Homo sapiens_hsa001901.92273017
18Parkinsons disease_Homo sapiens_hsa050121.91868346
19Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.88960107
20Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.86725726
21Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.85306796
22Adherens junction_Homo sapiens_hsa045201.81872260
23Pyruvate metabolism_Homo sapiens_hsa006201.80844294
24alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.80235279
25Proteasome_Homo sapiens_hsa030501.78349916
26Regulation of actin cytoskeleton_Homo sapiens_hsa048101.76232802
27Shigellosis_Homo sapiens_hsa051311.75959666
28Rap1 signaling pathway_Homo sapiens_hsa040151.73699388
29Non-homologous end-joining_Homo sapiens_hsa034501.71258261
30Proteoglycans in cancer_Homo sapiens_hsa052051.66987563
31Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.65618251
32Focal adhesion_Homo sapiens_hsa045101.65230679
33Huntingtons disease_Homo sapiens_hsa050161.64029889
34Platelet activation_Homo sapiens_hsa046111.57275512
35VEGF signaling pathway_Homo sapiens_hsa043701.52852702
36Protein export_Homo sapiens_hsa030601.52256635
37Renal cell carcinoma_Homo sapiens_hsa052111.52046844
38Arachidonic acid metabolism_Homo sapiens_hsa005901.48877644
39Fanconi anemia pathway_Homo sapiens_hsa034601.47883033
40Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.45358465
412-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.44011302
42Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.42560280
43Cysteine and methionine metabolism_Homo sapiens_hsa002701.41491254
44Hippo signaling pathway_Homo sapiens_hsa043901.41256226
45DNA replication_Homo sapiens_hsa030301.40093046
46Dilated cardiomyopathy_Homo sapiens_hsa054141.37488155
47Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.37298094
48Vitamin B6 metabolism_Homo sapiens_hsa007501.32371996
49Basal transcription factors_Homo sapiens_hsa030221.31277749
50Steroid biosynthesis_Homo sapiens_hsa001001.31011277
51Dorso-ventral axis formation_Homo sapiens_hsa043201.30837290
52Oocyte meiosis_Homo sapiens_hsa041141.30784419
53Steroid hormone biosynthesis_Homo sapiens_hsa001401.29737871
54Small cell lung cancer_Homo sapiens_hsa052221.28507518
55ECM-receptor interaction_Homo sapiens_hsa045121.25562097
56Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.25488787
57Purine metabolism_Homo sapiens_hsa002301.23624099
58Propanoate metabolism_Homo sapiens_hsa006401.22347563
59Vitamin digestion and absorption_Homo sapiens_hsa049771.20756204
60Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.19696662
61MicroRNAs in cancer_Homo sapiens_hsa052061.18936503
62Biosynthesis of amino acids_Homo sapiens_hsa012301.16519499
63Vascular smooth muscle contraction_Homo sapiens_hsa042701.16266048
64Carbon metabolism_Homo sapiens_hsa012001.15454735
65Acute myeloid leukemia_Homo sapiens_hsa052211.12554958
66Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.11665939
67Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.11229240
68Alzheimers disease_Homo sapiens_hsa050101.11215640
69Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.10758195
70mRNA surveillance pathway_Homo sapiens_hsa030151.09028214
71Phospholipase D signaling pathway_Homo sapiens_hsa040721.08068705
72Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.08035972
73Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.07947537
74Spliceosome_Homo sapiens_hsa030401.06300246
75Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.05226376
76TGF-beta signaling pathway_Homo sapiens_hsa043501.03231971
77Arginine and proline metabolism_Homo sapiens_hsa003301.00135562
78Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.98347284
79PI3K-Akt signaling pathway_Homo sapiens_hsa041510.98048125
80Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.97759245
81Bladder cancer_Homo sapiens_hsa052190.97111578
82Pathways in cancer_Homo sapiens_hsa052000.94955437
83Salmonella infection_Homo sapiens_hsa051320.94648153
84Estrogen signaling pathway_Homo sapiens_hsa049150.94288460
85Cyanoamino acid metabolism_Homo sapiens_hsa004600.90190801
86Gap junction_Homo sapiens_hsa045400.89048464
87Prostate cancer_Homo sapiens_hsa052150.88735523
88Antigen processing and presentation_Homo sapiens_hsa046120.88078271
89One carbon pool by folate_Homo sapiens_hsa006700.87835608
90Ether lipid metabolism_Homo sapiens_hsa005650.85486831
91Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.84260011
92Glutathione metabolism_Homo sapiens_hsa004800.84147456
93Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.84092284
94RNA degradation_Homo sapiens_hsa030180.83124876
95Pentose phosphate pathway_Homo sapiens_hsa000300.82946750
96Legionellosis_Homo sapiens_hsa051340.82547039
97HTLV-I infection_Homo sapiens_hsa051660.81065500
98Ovarian steroidogenesis_Homo sapiens_hsa049130.80601082
99Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.80439874
100Endocytosis_Homo sapiens_hsa041440.79474383
101Metabolic pathways_Homo sapiens_hsa011000.77770521
102Selenocompound metabolism_Homo sapiens_hsa004500.76751428
103Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.75513803
104Choline metabolism in cancer_Homo sapiens_hsa052310.74915073
105Thyroid hormone signaling pathway_Homo sapiens_hsa049190.74775162
106Axon guidance_Homo sapiens_hsa043600.74637729
107Endometrial cancer_Homo sapiens_hsa052130.73401578
108Arginine biosynthesis_Homo sapiens_hsa002200.72283759
109Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.71475682
110Ras signaling pathway_Homo sapiens_hsa040140.70655024
111N-Glycan biosynthesis_Homo sapiens_hsa005100.70208995
112Central carbon metabolism in cancer_Homo sapiens_hsa052300.68531532
113AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.67623866
114Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.67601138
115mTOR signaling pathway_Homo sapiens_hsa041500.66637039
116Complement and coagulation cascades_Homo sapiens_hsa046100.65884648
117Pancreatic cancer_Homo sapiens_hsa052120.65494338
118Viral myocarditis_Homo sapiens_hsa054160.65084232
119Viral carcinogenesis_Homo sapiens_hsa052030.64267433
120Pyrimidine metabolism_Homo sapiens_hsa002400.62666802
121HIF-1 signaling pathway_Homo sapiens_hsa040660.62109988
122Hepatitis C_Homo sapiens_hsa051600.61384510
123Fructose and mannose metabolism_Homo sapiens_hsa000510.61209730
124Colorectal cancer_Homo sapiens_hsa052100.60931791
125Sphingolipid metabolism_Homo sapiens_hsa006000.60281099
126Epstein-Barr virus infection_Homo sapiens_hsa051690.59984198
127Fat digestion and absorption_Homo sapiens_hsa049750.58630201
128Nucleotide excision repair_Homo sapiens_hsa034200.57415502
129Systemic lupus erythematosus_Homo sapiens_hsa053220.53671637
130Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.52745062
131Chronic myeloid leukemia_Homo sapiens_hsa052200.52600774
132Sphingolipid signaling pathway_Homo sapiens_hsa040710.51749225
133Ribosome_Homo sapiens_hsa030100.50929241
134Glioma_Homo sapiens_hsa052140.50555129
135Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.50294100
136RNA polymerase_Homo sapiens_hsa030200.49952180
137Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.49026905
138Sulfur metabolism_Homo sapiens_hsa009200.48186066
139Non-small cell lung cancer_Homo sapiens_hsa052230.47206893
140Neurotrophin signaling pathway_Homo sapiens_hsa047220.46972832
141Vibrio cholerae infection_Homo sapiens_hsa051100.44167855
142Drug metabolism - other enzymes_Homo sapiens_hsa009830.43351194
143p53 signaling pathway_Homo sapiens_hsa041150.42721794
144Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.42622422
145Fatty acid metabolism_Homo sapiens_hsa012120.42373599
146Alcoholism_Homo sapiens_hsa050340.42251839
147Apoptosis_Homo sapiens_hsa042100.40673754
148Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.39350305
149Peroxisome_Homo sapiens_hsa041460.38978644
150Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.38376090
151GnRH signaling pathway_Homo sapiens_hsa049120.37118372
152Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.35550362
153Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.32902597
154Phenylalanine metabolism_Homo sapiens_hsa003600.30520910
155Cardiac muscle contraction_Homo sapiens_hsa042600.29264115
156Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.25595667
157Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.24498878
158Lysine degradation_Homo sapiens_hsa003100.24329217
159Hedgehog signaling pathway_Homo sapiens_hsa043400.17063819
160Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.09985193
161Fatty acid biosynthesis_Homo sapiens_hsa000610.09591106
162Fatty acid degradation_Homo sapiens_hsa000710.09029709
163Inositol phosphate metabolism_Homo sapiens_hsa005620.07729387
164Wnt signaling pathway_Homo sapiens_hsa043100.07316475

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