PLAC8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)6.12181982
2DNA deamination (GO:0045006)5.55821654
3negative regulation of phagocytosis (GO:0050765)5.24403004
4immunoglobulin mediated immune response (GO:0016064)5.20067909
5positive regulation of gamma-delta T cell activation (GO:0046645)5.05664562
6antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.88387932
7regulation of B cell receptor signaling pathway (GO:0050855)4.87141286
8antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.80121559
9antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.80121559
10neutrophil mediated immunity (GO:0002446)4.77318350
11disruption of cells of other organism involved in symbiotic interaction (GO:0051818)4.67275783
12killing of cells in other organism involved in symbiotic interaction (GO:0051883)4.67275783
13DNA strand elongation involved in DNA replication (GO:0006271)4.56628947
14regulation of growth of symbiont in host (GO:0044126)4.56398116
15negative regulation of growth of symbiont in host (GO:0044130)4.56398116
16negative regulation of growth of symbiont involved in interaction with host (GO:0044146)4.56398116
17modulation of growth of symbiont involved in interaction with host (GO:0044144)4.56398116
18telomere maintenance via semi-conservative replication (GO:0032201)4.56139720
19viral transcription (GO:0019083)4.54237404
20defense response to fungus (GO:0050832)4.49656277
21translational termination (GO:0006415)4.38845969
22DNA strand elongation (GO:0022616)4.36120715
23SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.30705544
24B cell mediated immunity (GO:0019724)4.20972140
25cotranslational protein targeting to membrane (GO:0006613)4.20650821
26protein targeting to ER (GO:0045047)4.18045549
27negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.16886981
28negative regulation of cell killing (GO:0031342)4.16886981
29response to fungus (GO:0009620)4.08015131
30Arp2/3 complex-mediated actin nucleation (GO:0034314)4.01245232
31antigen processing and presentation of endogenous antigen (GO:0019883)3.99901323
32protein localization to endoplasmic reticulum (GO:0070972)3.97947405
33establishment of protein localization to endoplasmic reticulum (GO:0072599)3.97119319
34telomere maintenance via recombination (GO:0000722)3.91982349
35translational elongation (GO:0006414)3.91553714
36negative thymic T cell selection (GO:0045060)3.88843536
37myeloid leukocyte mediated immunity (GO:0002444)3.88501206
38disruption of cells of other organism (GO:0044364)3.85896644
39killing of cells of other organism (GO:0031640)3.85896644
40negative T cell selection (GO:0043383)3.83384732
41ribosomal small subunit biogenesis (GO:0042274)3.82026978
42leukocyte aggregation (GO:0070486)3.81209895
43cellular response to zinc ion (GO:0071294)3.77639478
44DNA replication initiation (GO:0006270)3.74738193
45DNA unwinding involved in DNA replication (GO:0006268)3.73790186
46regulation of gamma-delta T cell activation (GO:0046643)3.67614465
47B cell receptor signaling pathway (GO:0050853)3.66290030
48regulation of B cell differentiation (GO:0045577)3.62495246
49regulation of gamma-delta T cell differentiation (GO:0045586)3.60621906
50pentose-phosphate shunt (GO:0006098)3.59362279
51detection of bacterium (GO:0016045)3.58791483
52interferon-gamma-mediated signaling pathway (GO:0060333)3.57437207
53positive regulation of antigen processing and presentation (GO:0002579)3.57251363
54regulation of germinal center formation (GO:0002634)3.54979770
55T cell migration (GO:0072678)3.54346317
56mitotic recombination (GO:0006312)3.54121403
57positive thymic T cell selection (GO:0045059)3.52440427
58cellular response to type I interferon (GO:0071357)3.49485617
59type I interferon signaling pathway (GO:0060337)3.49485617
60response to type I interferon (GO:0034340)3.47581406
61detection of other organism (GO:0098543)3.46198676
62regulation of alpha-beta T cell proliferation (GO:0046640)3.43742409
63cellular protein complex disassembly (GO:0043624)3.42989961
64respiratory burst (GO:0045730)3.42906972
65regulation of antigen processing and presentation (GO:0002577)3.41206364
66nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.41053191
67viral life cycle (GO:0019058)3.40716412
68L-fucose catabolic process (GO:0042355)3.39318224
69fucose catabolic process (GO:0019317)3.39318224
70L-fucose metabolic process (GO:0042354)3.39318224
71response to peptidoglycan (GO:0032494)3.38567724
72angiotensin maturation (GO:0002003)3.35823214
73regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.35814507
74modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.35750160
75positive regulation by organism of defense response of other organism involved in symbiotic interact3.35750160
76modulation by symbiont of host immune response (GO:0052553)3.35750160
77positive regulation by symbiont of host defense response (GO:0052509)3.35750160
78modulation by symbiont of host defense response (GO:0052031)3.35750160
79modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.35750160
80cellular extravasation (GO:0045123)3.35370236
81angiogenesis involved in wound healing (GO:0060055)3.34176031
82microglial cell activation (GO:0001774)3.33068623
83maturation of SSU-rRNA (GO:0030490)3.32426471
84defense response to protozoan (GO:0042832)3.32263451
85telomere maintenance via telomere lengthening (GO:0010833)3.29307631
86regulation of hypersensitivity (GO:0002883)3.29280438
87translational initiation (GO:0006413)3.29191471
88NADPH regeneration (GO:0006740)3.27322450
89macrophage activation involved in immune response (GO:0002281)3.25829191
90nucleobase biosynthetic process (GO:0046112)3.21417049
91neutrophil activation (GO:0042119)3.21011303
92IMP metabolic process (GO:0046040)3.21003054
93myeloid cell activation involved in immune response (GO:0002275)3.18080061
94positive regulation of alpha-beta T cell proliferation (GO:0046641)3.17419250
95purine deoxyribonucleotide catabolic process (GO:0009155)3.10327923
96cellular response to interleukin-15 (GO:0071350)3.08921136
97nucleotide-excision repair, DNA gap filling (GO:0006297)3.08713823
98negative regulation of lymphocyte mediated immunity (GO:0002707)3.06432242
99protein complex disassembly (GO:0043241)3.04215020
100regulation of dendritic cell antigen processing and presentation (GO:0002604)3.03025183
101positive T cell selection (GO:0043368)3.02908587
102positive regulation of granulocyte differentiation (GO:0030854)3.02860712
103actin nucleation (GO:0045010)3.01806858
104DNA replication checkpoint (GO:0000076)3.01710764
105positive regulation of B cell differentiation (GO:0045579)3.01143960
106positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.98415934
107positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.96518996
108negative regulation of T cell mediated immunity (GO:0002710)2.96386659
109mature B cell differentiation involved in immune response (GO:0002313)2.96189774
110response to interleukin-15 (GO:0070672)2.96051221
111T cell selection (GO:0045058)2.94194972
112regulation of tolerance induction (GO:0002643)2.93812633
113regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.92304922
114regulation of mast cell degranulation (GO:0043304)2.92096436
115leukocyte mediated cytotoxicity (GO:0001909)2.88984948
116cellular response to exogenous dsRNA (GO:0071360)2.88927137
117mast cell activation (GO:0045576)2.88569673
118antigen processing and presentation via MHC class Ib (GO:0002475)2.87343066
119tolerance induction (GO:0002507)2.86170009
120IMP biosynthetic process (GO:0006188)2.86030054
121positive regulation of T cell mediated cytotoxicity (GO:0001916)2.85371684
122antigen receptor-mediated signaling pathway (GO:0050851)2.84140261
123macromolecular complex disassembly (GO:0032984)2.83969462
124regulation of T cell mediated cytotoxicity (GO:0001914)2.83645006
125purine nucleobase biosynthetic process (GO:0009113)2.82494823
126negative regulation of interleukin-12 production (GO:0032695)2.82368547
127response to interferon-beta (GO:0035456)2.82220008
128pentose metabolic process (GO:0019321)2.82196223
129thymic T cell selection (GO:0045061)2.80510495
130glucose 6-phosphate metabolic process (GO:0051156)2.80502137
131positive regulation of mast cell activation (GO:0033005)2.77968488
132negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.77361298
133regulation of mast cell activation (GO:0033003)2.76773316
134response to host immune response (GO:0052572)2.75794821
135response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.75794821
136cellular response to interferon-gamma (GO:0071346)2.75773112
137regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.75710804
138reactive oxygen species biosynthetic process (GO:1903409)2.75371739
139nuclear-transcribed mRNA catabolic process (GO:0000956)2.75290835
140negative regulation of leukocyte mediated immunity (GO:0002704)2.75060632
141regulation of protein heterodimerization activity (GO:0043497)2.74320736
142ribosomal large subunit biogenesis (GO:0042273)2.73633491
143granulocyte activation (GO:0036230)2.73526830
144detection of external biotic stimulus (GO:0098581)2.73009003
145mast cell activation involved in immune response (GO:0002279)2.71646692
146mast cell degranulation (GO:0043303)2.71646692
147protein targeting to membrane (GO:0006612)2.70879207
148protein localization to kinetochore (GO:0034501)2.70189008
149autophagic vacuole fusion (GO:0000046)2.69599130
150regulation of mast cell activation involved in immune response (GO:0033006)2.67831975
151leukocyte degranulation (GO:0043299)2.67424492
152necroptotic process (GO:0070266)2.67028653
153positive regulation of interferon-alpha production (GO:0032727)2.66889839
154interferon-gamma production (GO:0032609)2.66447079
155positive regulation of B cell activation (GO:0050871)2.66278809
156translation (GO:0006412)2.65332239
157signal peptide processing (GO:0006465)2.65313262
158lymphoid progenitor cell differentiation (GO:0002320)2.65089305
159pseudouridine synthesis (GO:0001522)2.65060244
160CENP-A containing nucleosome assembly (GO:0034080)2.64755239
161mRNA catabolic process (GO:0006402)2.62779732
162leukotriene biosynthetic process (GO:0019370)2.62234513
163purine nucleotide salvage (GO:0032261)2.61276424
164DNA topological change (GO:0006265)2.59427130
165cellular response to interferon-beta (GO:0035458)2.58889642
166deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.58500042
167negative regulation of RNA splicing (GO:0033119)2.57583435
168formation of translation preinitiation complex (GO:0001731)2.56965461
169purine-containing compound salvage (GO:0043101)2.56172370
170chromatin remodeling at centromere (GO:0031055)2.54865581
171RNA catabolic process (GO:0006401)2.54676937
172ribonucleoprotein complex biogenesis (GO:0022613)2.54125509
173hydrogen peroxide catabolic process (GO:0042744)2.53594115
174neutrophil activation involved in immune response (GO:0002283)2.51888749
175macrophage differentiation (GO:0030225)2.51739139
176response to protozoan (GO:0001562)2.47345363
177purine nucleobase metabolic process (GO:0006144)2.46895325
178telomere maintenance (GO:0000723)2.46098620
179telomere organization (GO:0032200)2.45553112

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.76904289
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.68029302
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.07783952
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.02123177
5E2F4_17652178_ChIP-ChIP_JURKAT_Human2.79223332
6* MYB_21317192_ChIP-Seq_ERMYB_Mouse2.78323366
7SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.75747426
8VDR_21846776_ChIP-Seq_THP-1_Human2.66078244
9ELF1_17652178_ChIP-ChIP_JURKAT_Human2.64276529
10* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.62660989
11RUNX_20019798_ChIP-Seq_JUKART_Human2.59851208
12FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.48559533
13FOXM1_23109430_ChIP-Seq_U2OS_Human2.48139040
14IRF8_22096565_ChIP-ChIP_GC-B_Human2.37659470
15SCL_19346495_ChIP-Seq_HPC-7_Human2.35739692
16NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.31997794
17KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.27667205
18FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.26726740
19EGR1_19374776_ChIP-ChIP_THP-1_Human2.26417702
20TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.25765594
21MYC_18358816_ChIP-ChIP_MESCs_Mouse2.23215512
22MYC_22102868_ChIP-Seq_BL_Human2.21955712
23EST1_17652178_ChIP-ChIP_JURKAT_Human2.19308309
24FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.19009313
25RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.18350724
26CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.17294835
27GABP_17652178_ChIP-ChIP_JURKAT_Human2.15033790
28IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.14656644
29SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.12555470
30SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.11594328
31SPI1_23547873_ChIP-Seq_NB4_Human2.08062672
32JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.99195097
33IRF8_21731497_ChIP-ChIP_J774_Mouse1.98405140
34GATA1_22025678_ChIP-Seq_K562_Human1.93253604
35MYC_19030024_ChIP-ChIP_MESCs_Mouse1.93199540
36* GATA3_27048872_Chip-Seq_THYMUS_Human1.92863411
37VDR_24763502_ChIP-Seq_THP-1_Human1.90160441
38ETS1_20019798_ChIP-Seq_JURKAT_Human1.89605771
39VDR_23849224_ChIP-Seq_CD4+_Human1.88082488
40HOXB4_20404135_ChIP-ChIP_EML_Mouse1.86760597
41SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.86390873
42MYC_19079543_ChIP-ChIP_MESCs_Mouse1.85413305
43HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.84707566
44ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.82752219
45* GATA3_26560356_Chip-Seq_TH2_Human1.81092484
46ERG_20887958_ChIP-Seq_HPC-7_Mouse1.79689321
47FOXP3_21729870_ChIP-Seq_TREG_Human1.76550788
48NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.73613059
49BRD4_27068464_Chip-Seq_AML-cells_Mouse1.71297974
50CREB1_15753290_ChIP-ChIP_HEK293T_Human1.70206523
51XRN2_22483619_ChIP-Seq_HELA_Human1.69736226
52RUNX1_22412390_ChIP-Seq_EML_Mouse1.65925755
53BP1_19119308_ChIP-ChIP_Hs578T_Human1.64972954
54CIITA_25753668_ChIP-Seq_RAJI_Human1.64342533
55E2F1_21310950_ChIP-Seq_MCF-7_Human1.61027891
56* MYB_26560356_Chip-Seq_TH2_Human1.58651454
57* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.57209411
58VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.56445210
59VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.52895034
60RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.52245427
61FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.47083770
62NELFA_20434984_ChIP-Seq_ESCs_Mouse1.46543778
63VDR_24787735_ChIP-Seq_THP-1_Human1.46266223
64* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.45340516
65STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.45165043
66* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.45098971
67DCP1A_22483619_ChIP-Seq_HELA_Human1.44145029
68GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.43834123
69AR_21909140_ChIP-Seq_LNCAP_Human1.43484236
70IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.41318534
71MYB_26560356_Chip-Seq_TH1_Human1.41103156
72* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.40785332
73MAF_26560356_Chip-Seq_TH1_Human1.39950108
74MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.35790471
75EGR1_23403033_ChIP-Seq_LIVER_Mouse1.35327913
76* UTX_26944678_Chip-Seq_JUKART_Human1.35110340
77GABP_19822575_ChIP-Seq_HepG2_Human1.34870417
78BCL6_27268052_Chip-Seq_Bcells_Human1.34146757
79E2F1_18555785_ChIP-Seq_MESCs_Mouse1.33505097
80GATA2_22383799_ChIP-Seq_G1ME_Mouse1.32595883
81LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.30873768
82SRF_21415370_ChIP-Seq_HL-1_Mouse1.28427584
83LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.27272717
84IRF8_27001747_Chip-Seq_BMDM_Mouse1.27030580
85TTF2_22483619_ChIP-Seq_HELA_Human1.26980237
86STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.23224146
87PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.23188819
88CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.22111835
89HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.21201196
90YY1_21170310_ChIP-Seq_MESCs_Mouse1.21125925
91ELK1_19687146_ChIP-ChIP_HELA_Human1.19289312
92* P300_27268052_Chip-Seq_Bcells_Human1.17861431
93CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.17839169
94MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.15756315
95ZFX_18555785_ChIP-Seq_MESCs_Mouse1.15530105
96STAT1_20625510_ChIP-Seq_HELA_Human1.15302168
97CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.11272785
98CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.10834326
99ELF1_20517297_ChIP-Seq_JURKAT_Human1.10633130
100CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.07912993
101MYCN_18555785_ChIP-Seq_MESCs_Mouse1.06492888
102MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.06390022
103PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.06247508
104PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.04769606
105RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.03943414
106SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.03226482
107NOTCH1_21737748_ChIP-Seq_TLL_Human1.02874644
108TCF7_22412390_ChIP-Seq_EML_Mouse1.02871342
109E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.02543379
110CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.01928020
111BCOR_27268052_Chip-Seq_Bcells_Human1.01883387
112* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01361187
113KDM5A_27292631_Chip-Seq_BREAST_Human0.99630549
114GATA1_19941827_ChIP-Seq_MEL_Mouse0.99318373
115* GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.98808184
116THAP11_20581084_ChIP-Seq_MESCs_Mouse0.97886806
117PU.1_20513432_ChIP-Seq_Bcells_Mouse0.97705133
118SPI1_20517297_ChIP-Seq_HL60_Human0.97175616
119* STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.96909783
120CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.95617298
121FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.95527440
122* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.94672055
123EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.94107579
124GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93547361
125MAF_26560356_Chip-Seq_TH2_Human0.92289471
126* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.91980650
127PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.91670624
128STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.91400593
129SPI1_23127762_ChIP-Seq_K562_Human0.89664602
130PU_27001747_Chip-Seq_BMDM_Mouse0.89444850
131CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.89013028
132PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.87269756
133TFEB_21752829_ChIP-Seq_HELA_Human0.87176647
134* RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.86918478
135SMRT_27268052_Chip-Seq_Bcells_Human0.86252584
136RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.85962087
137CEBPB_22108803_ChIP-Seq_LS180_Human0.85152887
138* E2F1_20622854_ChIP-Seq_HELA_Human0.84486897
139CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.82817041
140Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.79237639
141TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.79001253
142TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.78738693
143GATA3_26560356_Chip-Seq_TH1_Human0.78421936
144PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.77995266
145GATA1_19941826_ChIP-Seq_K562_Human0.76759074
146CTCF_26484167_Chip-Seq_Bcells_Mouse0.76266242
147* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.76126972
148BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.75929263

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002396_abnormal_hematopoietic_system4.14072492
2MP0003693_abnormal_embryo_hatching3.48096766
3MP0001835_abnormal_antigen_presentation3.18487612
4MP0000490_abnormal_crypts_of2.69634313
5MP0002166_altered_tumor_susceptibility2.65414362
6MP0006082_CNS_inflammation2.61795174
7MP0009785_altered_susceptibility_to2.51260993
8MP0010094_abnormal_chromosome_stability2.49098518
9MP0000465_gastrointestinal_hemorrhage2.38887369
10MP0006054_spinal_hemorrhage2.38790571
11MP0003436_decreased_susceptibility_to2.34275111
12MP0005174_abnormal_tail_pigmentation2.30159807
13* MP0005025_abnormal_response_to2.24528771
14MP0005464_abnormal_platelet_physiology2.23927370
15* MP0002419_abnormal_innate_immunity2.19881903
16MP0001873_stomach_inflammation2.19688786
17MP0008057_abnormal_DNA_replication2.19351929
18MP0004957_abnormal_blastocyst_morpholog2.18426095
19MP0009333_abnormal_splenocyte_physiolog2.17043155
20MP0002148_abnormal_hypersensitivity_rea2.16861135
21MP0005397_hematopoietic_system_phenotyp2.13737507
22MP0001545_abnormal_hematopoietic_system2.13737507
23MP0003303_peritoneal_inflammation2.12216857
24MP0003763_abnormal_thymus_physiology2.09828082
25MP0002398_abnormal_bone_marrow2.09700623
26MP0003111_abnormal_nucleus_morphology2.09044533
27MP0002006_tumorigenesis2.08092406
28* MP0002420_abnormal_adaptive_immunity2.07588563
29MP0010155_abnormal_intestine_physiology2.07317421
30* MP0001819_abnormal_immune_cell2.04059503
31MP0003724_increased_susceptibility_to2.03125436
32MP0003866_abnormal_defecation2.01692808
33MP0005671_abnormal_response_to2.00337693
34MP0001800_abnormal_humoral_immune2.00302419
35MP0005000_abnormal_immune_tolerance1.98324107
36MP0003077_abnormal_cell_cycle1.96282202
37MP0002452_abnormal_antigen_presenting1.94718245
38MP0004808_abnormal_hematopoietic_stem1.93706834
39MP0000685_abnormal_immune_system1.93201954
40MP0009379_abnormal_foot_pigmentation1.93061206
41MP0003183_abnormal_peptide_metabolism1.91268594
42MP0002723_abnormal_immune_serum1.85077487
43* MP0000716_abnormal_immune_system1.83592296
44MP0001853_heart_inflammation1.79854925
45MP0005075_abnormal_melanosome_morpholog1.75268864
46MP0000689_abnormal_spleen_morphology1.74549376
47MP0002722_abnormal_immune_system1.72807961
48* MP0002429_abnormal_blood_cell1.71425998
49MP0000858_altered_metastatic_potential1.70301479
50MP0008007_abnormal_cellular_replicative1.58594404
51MP0008058_abnormal_DNA_repair1.55307097
52MP0009764_decreased_sensitivity_to1.53150476
53MP0002405_respiratory_system_inflammati1.52796282
54MP0001845_abnormal_inflammatory_respons1.51662569
55MP0003806_abnormal_nucleotide_metabolis1.49862876
56MP0002019_abnormal_tumor_incidence1.48496962
57MP0010352_gastrointestinal_tract_polyps1.47571718
58MP0001663_abnormal_digestive_system1.46956403
59MP0003300_gastrointestinal_ulcer1.36980361
60MP0010307_abnormal_tumor_latency1.36674018
61MP0002095_abnormal_skin_pigmentation1.32146006
62MP0000015_abnormal_ear_pigmentation1.30492509
63MP0001790_abnormal_immune_system1.29991307
64MP0005387_immune_system_phenotype1.29991307
65MP0000703_abnormal_thymus_morphology1.27253646
66MP0004264_abnormal_extraembryonic_tissu1.26185915
67MP0003172_abnormal_lysosome_physiology1.25950149
68MP0003252_abnormal_bile_duct1.15891252
69MP0008469_abnormal_protein_level1.13849479
70MP0005310_abnormal_salivary_gland1.11482259
71MP0000343_altered_response_to1.10519372
72MP0005166_decreased_susceptibility_to1.05967027
73MP0003186_abnormal_redox_activity1.04986355
74MP0001533_abnormal_skeleton_physiology1.04526710
75MP0004147_increased_porphyrin_level1.02290981
76MP0000477_abnormal_intestine_morphology1.01395316
77MP0003075_altered_response_to0.99715610
78MP0008875_abnormal_xenobiotic_pharmacok0.99072019
79MP0005645_abnormal_hypothalamus_physiol0.98957167
80MP0002138_abnormal_hepatobiliary_system0.97106473
81MP0000313_abnormal_cell_death0.96606701
82MP0005381_digestive/alimentary_phenotyp0.96186775
83MP0008873_increased_physiological_sensi0.95205217
84MP0002009_preneoplasia0.92418786
85MP0002876_abnormal_thyroid_physiology0.92093708
86MP0005360_urolithiasis0.91175045
87MP0003221_abnormal_cardiomyocyte_apopto0.90087193
88MP0000350_abnormal_cell_proliferation0.89906029
89MP0001765_abnormal_ion_homeostasis0.89504120
90MP0006036_abnormal_mitochondrial_physio0.86117128
91MP0003656_abnormal_erythrocyte_physiolo0.85167905
92MP0003191_abnormal_cellular_cholesterol0.84466112
93MP0004883_abnormal_blood_vessel0.83744327
94MP0001851_eye_inflammation0.83347391
95MP0004043_abnormal_pH_regulation0.80607109
96MP0004381_abnormal_hair_follicle0.80405517
97MP0005164_abnormal_response_to0.78473429
98MP0005319_abnormal_enzyme/_coenzyme0.78039693
99MP0002998_abnormal_bone_remodeling0.77393612
100MP0001986_abnormal_taste_sensitivity0.76854896
101MP0001666_abnormal_nutrient_absorption0.76821542
102MP0009278_abnormal_bone_marrow0.76047764
103MP0004947_skin_inflammation0.75561602
104MP0009840_abnormal_foam_cell0.74824773
105MP0009643_abnormal_urine_homeostasis0.74591267
106MP0001764_abnormal_homeostasis0.74391682
107MP0010234_abnormal_vibrissa_follicle0.73655831
108MP0002933_joint_inflammation0.73000340
109MP0005409_darkened_coat_color0.72600302
110MP0003786_premature_aging0.72566052
111MP0002693_abnormal_pancreas_physiology0.72121117
112MP0003448_altered_tumor_morphology0.71736257
113MP0001730_embryonic_growth_arrest0.71626529
114MP0008932_abnormal_embryonic_tissue0.70525027
115MP0008872_abnormal_physiological_respon0.69234979
116MP0009763_increased_sensitivity_to0.66350362
117MP0005085_abnormal_gallbladder_physiolo0.65486074
118MP0002136_abnormal_kidney_physiology0.65130835
119MP0009697_abnormal_copulation0.65020361
120MP0002277_abnormal_respiratory_mucosa0.64852574
121MP0009765_abnormal_xenobiotic_induced0.64157561
122MP0002163_abnormal_gland_morphology0.62199496
123MP0005058_abnormal_lysosome_morphology0.62090698
124MP0002139_abnormal_hepatobiliary_system0.60147164
125MP0000358_abnormal_cell_content/0.59824247
126* MP0000249_abnormal_blood_vessel0.58969948
127MP0005165_increased_susceptibility_to0.58819179
128MP0000371_diluted_coat_color0.58543161
129MP0003567_abnormal_fetal_cardiomyocyte0.58262802
130MP0005376_homeostasis/metabolism_phenot0.58020894
131MP0002132_abnormal_respiratory_system0.57801344
132MP0005584_abnormal_enzyme/coenzyme_acti0.57466621
133MP0008260_abnormal_autophagy0.57028651
134MP0003638_abnormal_response/metabolism_0.56844731

Predicted human phenotypes

RankGene SetZ-score
1Thrombocytosis (HP:0001894)6.41396063
2Agammaglobulinemia (HP:0004432)4.96800625
3Elevated erythrocyte sedimentation rate (HP:0003565)4.86753030
4Abnormal number of erythroid precursors (HP:0012131)4.78919416
5Abnormality of cells of the erythroid lineage (HP:0012130)4.72840605
6Reduced antithrombin III activity (HP:0001976)4.31915504
7Aplastic anemia (HP:0001915)4.24269741
8Reticulocytopenia (HP:0001896)4.17956802
9IgM deficiency (HP:0002850)4.08762307
10Chronic otitis media (HP:0000389)3.97164620
11Myositis (HP:0100614)3.75823561
12Petechiae (HP:0000967)3.75706426
13Recurrent abscess formation (HP:0002722)3.74897755
14Type I transferrin isoform profile (HP:0003642)3.57990987
15Recurrent bacterial skin infections (HP:0005406)3.53291607
16Stomatitis (HP:0010280)3.36594008
17Abnormality of the prostate (HP:0008775)3.36346869
18Chronic sinusitis (HP:0011109)3.35552924
19Autoimmune hemolytic anemia (HP:0001890)3.35268986
20B lymphocytopenia (HP:0010976)3.33058198
21Abnormality of B cell number (HP:0010975)3.33058198
22Abnormality of macrophages (HP:0004311)3.32054561
23Orchitis (HP:0100796)3.29868817
24Papilledema (HP:0001085)3.20529458
25Optic neuritis (HP:0100653)3.17577016
26Retrobulbar optic neuritis (HP:0100654)3.17577016
27Recurrent gram-negative bacterial infections (HP:0005420)3.15314022
28Abnormality of T cell physiology (HP:0011840)3.15056194
29Recurrent viral infections (HP:0004429)3.12808852
30Obstructive lung disease (HP:0006536)3.08030146
31Chronic obstructive pulmonary disease (HP:0006510)3.08030146
32Abnormal protein glycosylation (HP:0012346)3.05100193
33Abnormal glycosylation (HP:0012345)3.05100193
34Abnormal isoelectric focusing of serum transferrin (HP:0003160)3.05100193
35Abnormal protein N-linked glycosylation (HP:0012347)3.05100193
36Meningitis (HP:0001287)3.01266590
37Abnormality of T cell number (HP:0011839)2.97215604
38Increased IgM level (HP:0003496)2.91920193
39Chest pain (HP:0100749)2.90091856
40Severe combined immunodeficiency (HP:0004430)2.81451193
41Recurrent sinusitis (HP:0011108)2.81169419
42Urticaria (HP:0001025)2.78106939
43Bronchitis (HP:0012387)2.77837578
44Chronic diarrhea (HP:0002028)2.76724852
45Granulocytopenia (HP:0001913)2.76162930
46Eosinophilia (HP:0001880)2.75572166
47Recurrent bronchitis (HP:0002837)2.75550768
48Impaired platelet aggregation (HP:0003540)2.74141687
49Abnormal platelet function (HP:0011869)2.74141687
50Poikiloderma (HP:0001029)2.71004997
51Gastrointestinal infarctions (HP:0005244)2.69233733
52Eczematoid dermatitis (HP:0000976)2.67266888
53IgG deficiency (HP:0004315)2.65147794
54Pulmonary fibrosis (HP:0002206)2.64558808
55T lymphocytopenia (HP:0005403)2.64301308
56Recurrent fungal infections (HP:0002841)2.63200569
57Colitis (HP:0002583)2.60520099
58Macrocytic anemia (HP:0001972)2.60141779
59Pallor (HP:0000980)2.55332165
60Osteomyelitis (HP:0002754)2.54168292
61Papilloma (HP:0012740)2.49915990
62Verrucae (HP:0200043)2.49915990
63Bronchiectasis (HP:0002110)2.49357803
64Cellulitis (HP:0100658)2.48848461
65Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.45655888
66Recurrent pneumonia (HP:0006532)2.45329116
6711 pairs of ribs (HP:0000878)2.45085004
68Amyloidosis (HP:0011034)2.39384724
69Mediastinal lymphadenopathy (HP:0100721)2.33862706
70Recurrent skin infections (HP:0001581)2.33443539
71Epistaxis (HP:0000421)2.31767851
72Abnormality of T cells (HP:0002843)2.31313099
73Periodontitis (HP:0000704)2.31248195
74Lymphopenia (HP:0001888)2.30607232
75Gastrointestinal inflammation (HP:0004386)2.30568578
76Keratoconjunctivitis (HP:0001096)2.29119483
77Abnormality of cells of the lymphoid lineage (HP:0012140)2.28431567
78Oral leukoplakia (HP:0002745)2.28178087
79Keratoconjunctivitis sicca (HP:0001097)2.27722359
80Autoimmune thrombocytopenia (HP:0001973)2.26327081
81Inflammation of the large intestine (HP:0002037)2.24846269
82Hypergammaglobulinemia (HP:0010702)2.23598418
83Ureteral stenosis (HP:0000071)2.23131499
84Vasculitis (HP:0002633)2.21782846
85Prolonged bleeding time (HP:0003010)2.21538716
86Recurrent lower respiratory tract infections (HP:0002783)2.21055110
87Dynein arm defect of respiratory motile cilia (HP:0012255)2.20904247
88Absent/shortened dynein arms (HP:0200106)2.20904247
89Abnormal delayed hypersensitivity skin test (HP:0002963)2.20320928
90Nasal polyposis (HP:0100582)2.17544834
91Spontaneous hematomas (HP:0007420)2.17043461
92Acute lymphatic leukemia (HP:0006721)2.16929422
93Neutropenia (HP:0001875)2.16761593
94Lymphoma (HP:0002665)2.14449714
95Chromsome breakage (HP:0040012)2.13923859
96Abnormality of eosinophils (HP:0001879)2.12305725
97Pustule (HP:0200039)2.11980719
98Leukocytosis (HP:0001974)2.10040155
99Myelodysplasia (HP:0002863)2.09640835
100Gangrene (HP:0100758)2.09166110
101Combined immunodeficiency (HP:0005387)2.08467617
102Albinism (HP:0001022)2.08217176
103Hemoptysis (HP:0002105)2.07969435
104Exertional dyspnea (HP:0002875)2.07882600
105Acute myeloid leukemia (HP:0004808)2.07265895
106Gingival bleeding (HP:0000225)2.06785622
107Gastrointestinal stroma tumor (HP:0100723)2.06774832
108Pancytopenia (HP:0001876)2.06386133
109Panhypogammaglobulinemia (HP:0003139)2.05671513
110Abnormality of the thoracic spine (HP:0100711)2.04583162
111Abnormal respiratory motile cilium physiology (HP:0012261)2.04369020
112Gingivitis (HP:0000230)2.03868169
113Increased IgE level (HP:0003212)2.03682420
114Arterial thrombosis (HP:0004420)2.03443370
115Hypochromic anemia (HP:0001931)2.02923807
116Microretrognathia (HP:0000308)2.00978464
117Agnosia (HP:0010524)2.00607676
118Amaurosis fugax (HP:0100576)2.00282162
119Skin rash (HP:0000988)1.99407269
120Skin ulcer (HP:0200042)1.98809005
121Entropion (HP:0000621)1.98387863
122Pulmonary embolism (HP:0002204)1.97765581
123Interstitial pulmonary disease (HP:0006530)1.96212661
124Stomach cancer (HP:0012126)1.96037107
125Abnormality of the nasal mucosa (HP:0000433)1.95343217
126Sepsis (HP:0100806)1.95005269
127Abnormal respiratory motile cilium morphology (HP:0005938)1.94440299
128Abnormal respiratory epithelium morphology (HP:0012253)1.94440299
1293-Methylglutaconic aciduria (HP:0003535)1.93631366
130Ureteral obstruction (HP:0006000)1.93340502
131Thoracic kyphosis (HP:0002942)1.93109216
132Hypoplasia of the thymus (HP:0000778)1.92562555
133Anorexia (HP:0002039)1.92135327
134Pulmonary infiltrates (HP:0002113)1.91582669
135Aplasia/Hypoplasia of the thymus (HP:0010515)1.91450138
136Joint swelling (HP:0001386)1.90454070
137Abnormality of the pleura (HP:0002103)1.89105193
138Birth length less than 3rd percentile (HP:0003561)1.88703659
139Bone marrow hypocellularity (HP:0005528)1.87791125
140Encephalitis (HP:0002383)1.86705745
141Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.83066650
142Multiple enchondromatosis (HP:0005701)1.83026434
143Chronic mucocutaneous candidiasis (HP:0002728)1.81337956
144Recurrent cutaneous fungal infections (HP:0011370)1.81337956
145Abnormality of DNA repair (HP:0003254)1.80633244
146Thyroiditis (HP:0100646)1.80628167
147Poor head control (HP:0002421)1.80145281

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK163.35743853
2EIF2AK32.97386462
3TEC2.68642586
4IRAK42.64708391
5EEF2K2.60616678
6BMPR22.56354572
7PIM22.47303764
8KIT2.42612294
9MAP4K12.42477185
10SCYL22.33098492
11BTK2.21869009
12WEE12.15625495
13MAP3K122.08539949
14TAOK32.03063418
15CDC72.00746785
16FLT31.94903961
17NME21.73498892
18EIF2AK11.70579511
19VRK11.66672795
20BLK1.66276511
21TESK21.65694084
22RPS6KB21.65032791
23FES1.64815835
24ERN11.62444039
25IKBKB1.61294154
26BUB11.60353244
27GRK61.52800475
28TNK21.52537179
29BRSK21.43550381
30VRK21.37678334
31TNIK1.36008824
32MAP2K31.34902864
33NEK21.31635911
34LRRK21.30851106
35SYK1.27924610
36MAP3K131.23870350
37CSF1R1.22315021
38PAK41.21628691
39KDR1.21162090
40PKN21.20849385
41DYRK31.19680190
42ACVR1B1.19420392
43JAK11.17652822
44TYK21.15755415
45TESK11.14387444
46MST41.11956075
47GRK71.11142813
48TBK11.10538573
49CDK191.10439796
50CDK71.09818532
51MAPKAPK31.08835661
52ITK1.07647593
53PIM11.06795322
54ATR1.05635342
55TGFBR11.04966035
56TSSK61.02846825
57CLK11.02417713
58STK101.02348033
59ZAP701.01729540
60MYLK1.01712905
61MAP3K81.01238430
62PIK3CA0.99929016
63PASK0.97487086
64MAP3K60.96808077
65MAP2K60.96456698
66CDK80.96444388
67RPS6KA40.96118906
68IRAK30.94804057
69BCKDK0.94189591
70ZAK0.93324166
71MATK0.91702756
72AURKB0.87773864
73PRKCQ0.87732595
74LYN0.86205812
75FRK0.85264434
76SRPK10.84154777
77MAPK40.83365786
78JAK30.80067269
79NUAK10.79871636
80PDK10.79643760
81CDK40.76990295
82RAF10.76538997
83CAMKK20.76044265
84RIPK40.75522566
85MARK30.74218946
86GRK50.73994363
87TGFBR20.73894565
88JAK20.72876112
89MKNK10.72083161
90OXSR10.70924043
91TLK10.70008391
92IKBKE0.69496529
93DAPK10.68897714
94PLK40.65851605
95MAP3K110.65850636
96PTK2B0.65288595
97LCK0.63578987
98TRPM70.62809613
99RIPK10.62294932
100BRSK10.62237964
101MAP4K20.60071280
102RPS6KA60.59132098
103HIPK20.58015859
104EIF2AK20.56296165
105RPS6KC10.54896010
106RPS6KL10.54896010
107MAP2K20.54666907
108PLK10.54397679
109TXK0.53584196
110PRKG20.53527563
111ILK0.52774611
112CCNB10.52712379
113MAP3K100.52070921
114RPS6KA50.50873897
115MKNK20.49076352
116MST1R0.49075814
117TTK0.48652540
118MAPK120.48061161
119HCK0.48016875
120MAPK70.47880536
121MAP3K140.47733936
122PRKCD0.46429163
123ADRBK20.46380288
124MAPK110.45979179
125PDPK10.45973910
126IRAK10.45204449
127STK40.44994588
128MAPKAPK50.44254829
129MOS0.44056896
130FGR0.43912776
131ABL20.43440934
132PRPF4B0.43073091
133ABL10.42262238
134FYN0.41875615
135PIK3CG0.41768320
136CSK0.41699703
137EPHB10.40219235
138MAPKAPK20.38560275
139MAPK150.34465479
140IGF1R0.34116006
141MAP3K10.34028793
142ADRBK10.32782049
143MAP3K30.30764497
144SMG10.24643737
145EGFR0.21569335

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.05857491
2Graft-versus-host disease_Homo sapiens_hsa053324.10433917
3Allograft rejection_Homo sapiens_hsa053304.01736401
4Ribosome_Homo sapiens_hsa030103.91041007
5Autoimmune thyroid disease_Homo sapiens_hsa053203.85032368
6Mismatch repair_Homo sapiens_hsa034303.43550237
7Type I diabetes mellitus_Homo sapiens_hsa049403.17872345
8Base excision repair_Homo sapiens_hsa034102.81882305
9Homologous recombination_Homo sapiens_hsa034402.55872789
10Staphylococcus aureus infection_Homo sapiens_hsa051502.53221638
11Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.33632590
12Non-homologous end-joining_Homo sapiens_hsa034502.14696953
13Viral myocarditis_Homo sapiens_hsa054162.10561264
14Renin-angiotensin system_Homo sapiens_hsa046142.03940878
15Nucleotide excision repair_Homo sapiens_hsa034202.03928137
16Pentose phosphate pathway_Homo sapiens_hsa000302.03159829
17Protein export_Homo sapiens_hsa030602.02317601
18Spliceosome_Homo sapiens_hsa030401.99565905
19N-Glycan biosynthesis_Homo sapiens_hsa005101.98884484
20Proteasome_Homo sapiens_hsa030501.95772969
21Pyrimidine metabolism_Homo sapiens_hsa002401.93286275
22Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.77105485
23Primary immunodeficiency_Homo sapiens_hsa053401.77030780
24Antigen processing and presentation_Homo sapiens_hsa046121.70353068
25Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.62023281
26RNA polymerase_Homo sapiens_hsa030201.59946112
27Cell cycle_Homo sapiens_hsa041101.56584630
28Other glycan degradation_Homo sapiens_hsa005111.52341375
29Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.49420907
30Leishmaniasis_Homo sapiens_hsa051401.46073070
31Fanconi anemia pathway_Homo sapiens_hsa034601.42432884
32Galactose metabolism_Homo sapiens_hsa000521.42204218
33Rheumatoid arthritis_Homo sapiens_hsa053231.35791843
34Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.34956167
35One carbon pool by folate_Homo sapiens_hsa006701.32703963
36RNA transport_Homo sapiens_hsa030131.31475662
37RNA degradation_Homo sapiens_hsa030181.25385198
38RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.19662339
39Herpes simplex infection_Homo sapiens_hsa051681.15813262
40T cell receptor signaling pathway_Homo sapiens_hsa046601.13320918
41Purine metabolism_Homo sapiens_hsa002301.11435788
42Asthma_Homo sapiens_hsa053101.05969213
43Hematopoietic cell lineage_Homo sapiens_hsa046401.05489907
44Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.05428931
45Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.04327812
46Legionellosis_Homo sapiens_hsa051341.02858738
47Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.99921307
48B cell receptor signaling pathway_Homo sapiens_hsa046620.99823373
49Intestinal immune network for IgA production_Homo sapiens_hsa046720.99570820
50SNARE interactions in vesicular transport_Homo sapiens_hsa041300.99143992
51Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.97537375
52Glycosaminoglycan degradation_Homo sapiens_hsa005310.95839250
53Measles_Homo sapiens_hsa051620.93894033
54Glutathione metabolism_Homo sapiens_hsa004800.92146581
55p53 signaling pathway_Homo sapiens_hsa041150.92073629
56Systemic lupus erythematosus_Homo sapiens_hsa053220.90307337
57Thyroid cancer_Homo sapiens_hsa052160.89676547
58Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.89580961
59Sulfur relay system_Homo sapiens_hsa041220.88793050
60Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.85808498
61Folate biosynthesis_Homo sapiens_hsa007900.85562843
62Pertussis_Homo sapiens_hsa051330.84413848
63NF-kappa B signaling pathway_Homo sapiens_hsa040640.83171441
64Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.83084032
65African trypanosomiasis_Homo sapiens_hsa051430.81230144
66Phagosome_Homo sapiens_hsa041450.81021465
67Malaria_Homo sapiens_hsa051440.80779950
68NOD-like receptor signaling pathway_Homo sapiens_hsa046210.79606865
69Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.79385063
70Transcriptional misregulation in cancer_Homo sapiens_hsa052020.78860880
71Drug metabolism - other enzymes_Homo sapiens_hsa009830.75518947
72Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.75204052
73Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.74179339
74Shigellosis_Homo sapiens_hsa051310.74126417
75Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.74072104
76Apoptosis_Homo sapiens_hsa042100.72794342
77alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.72370848
78Influenza A_Homo sapiens_hsa051640.72190030
79Chemokine signaling pathway_Homo sapiens_hsa040620.72141936
80Starch and sucrose metabolism_Homo sapiens_hsa005000.71831478
81Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.71034708
82Linoleic acid metabolism_Homo sapiens_hsa005910.70176475
83Osteoclast differentiation_Homo sapiens_hsa043800.69134747
84Epstein-Barr virus infection_Homo sapiens_hsa051690.67349566
85Caffeine metabolism_Homo sapiens_hsa002320.65733887
86Leukocyte transendothelial migration_Homo sapiens_hsa046700.65336951
87Acute myeloid leukemia_Homo sapiens_hsa052210.64671954
88Hepatitis B_Homo sapiens_hsa051610.64447419
89Hepatitis C_Homo sapiens_hsa051600.61882571
90Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.61742512
91Cyanoamino acid metabolism_Homo sapiens_hsa004600.61651635
92Nitrogen metabolism_Homo sapiens_hsa009100.61416583
93Toll-like receptor signaling pathway_Homo sapiens_hsa046200.61228933
94Arachidonic acid metabolism_Homo sapiens_hsa005900.59277652
95Toxoplasmosis_Homo sapiens_hsa051450.58699801
96TNF signaling pathway_Homo sapiens_hsa046680.57441635
97Ether lipid metabolism_Homo sapiens_hsa005650.56165265
98Oxidative phosphorylation_Homo sapiens_hsa001900.55380068
99Chemical carcinogenesis_Homo sapiens_hsa052040.55059781
100Salmonella infection_Homo sapiens_hsa051320.54884551
101Regulation of autophagy_Homo sapiens_hsa041400.54877805
102Basal transcription factors_Homo sapiens_hsa030220.54610722
103Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.53756272
104Viral carcinogenesis_Homo sapiens_hsa052030.53153714
105Fructose and mannose metabolism_Homo sapiens_hsa000510.52519927
106Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.52167201
107Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.52025184
108Carbohydrate digestion and absorption_Homo sapiens_hsa049730.50135583
109Tuberculosis_Homo sapiens_hsa051520.49698031
110Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.49697323
111Jak-STAT signaling pathway_Homo sapiens_hsa046300.48975339
112Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.48378312
113Small cell lung cancer_Homo sapiens_hsa052220.47932267
114Carbon metabolism_Homo sapiens_hsa012000.45860112
115Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.44741908
116Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.44225664
117Biosynthesis of amino acids_Homo sapiens_hsa012300.43961395
118Glycerophospholipid metabolism_Homo sapiens_hsa005640.42845030
119Platelet activation_Homo sapiens_hsa046110.42599957
120Fat digestion and absorption_Homo sapiens_hsa049750.42568124
121Parkinsons disease_Homo sapiens_hsa050120.41383954
122Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.41204774
123Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.40833018
124Vitamin digestion and absorption_Homo sapiens_hsa049770.38621840
125Chronic myeloid leukemia_Homo sapiens_hsa052200.35550110
126Sulfur metabolism_Homo sapiens_hsa009200.34970996
127Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.34397107
128Pentose and glucuronate interconversions_Homo sapiens_hsa000400.33988055
129Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.32877941
130Steroid hormone biosynthesis_Homo sapiens_hsa001400.32519889
131mRNA surveillance pathway_Homo sapiens_hsa030150.30924804
132Selenocompound metabolism_Homo sapiens_hsa004500.29944906
133HTLV-I infection_Homo sapiens_hsa051660.28983103
134Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.26094175
135Huntingtons disease_Homo sapiens_hsa050160.25281795
136Peroxisome_Homo sapiens_hsa041460.18715871
137Retinol metabolism_Homo sapiens_hsa008300.17689633
138Pancreatic cancer_Homo sapiens_hsa052120.15051070
139Alcoholism_Homo sapiens_hsa050340.14874373
140Alzheimers disease_Homo sapiens_hsa050100.14741672
141Non-small cell lung cancer_Homo sapiens_hsa052230.14117392
142Tryptophan metabolism_Homo sapiens_hsa003800.12919919
143Sphingolipid signaling pathway_Homo sapiens_hsa040710.09373327

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