PLAC8L1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axonemal dynein complex assembly (GO:0070286)9.85640757
2spermatid development (GO:0007286)9.81235761
3epithelial cilium movement (GO:0003351)9.76846933
4motile cilium assembly (GO:0044458)9.28969532
5cilium or flagellum-dependent cell motility (GO:0001539)9.27348557
6regulation of cilium movement (GO:0003352)9.11992319
7reproduction (GO:0000003)9.06041629
8cilium movement (GO:0003341)7.92500355
9piRNA metabolic process (GO:0034587)7.43369156
10sperm capacitation (GO:0048240)7.30114235
11epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.28899095
12single fertilization (GO:0007338)7.27932266
13negative regulation of inclusion body assembly (GO:0090084)7.27920017
14organic cation transport (GO:0015695)7.10564707
15male meiosis (GO:0007140)6.96595138
16synaptonemal complex organization (GO:0070193)6.87444179
17synaptonemal complex assembly (GO:0007130)6.69787804
18spermatogenesis (GO:0007283)6.66310438
19male gamete generation (GO:0048232)6.63814076
20microtubule depolymerization (GO:0007019)6.29925933
21fertilization (GO:0009566)6.25942953
22gamete generation (GO:0007276)6.08245192
23regulation of inclusion body assembly (GO:0090083)6.04489952
24calcium ion-dependent exocytosis (GO:0017156)5.57138210
25cellular process involved in reproduction in multicellular organism (GO:0022412)5.47258457
26germ cell development (GO:0007281)5.39610089
27regulation of microtubule-based movement (GO:0060632)5.31715161
28cell recognition (GO:0008037)5.05959014
29ventricular system development (GO:0021591)5.03417515
30replication fork processing (GO:0031297)4.80347959
31male meiosis I (GO:0007141)4.80199988
32multicellular organismal reproductive process (GO:0048609)4.78642811
33chromosome condensation (GO:0030261)4.72615721
34glycerol ether metabolic process (GO:0006662)4.62351702
35DNA methylation involved in gamete generation (GO:0043046)4.57241743
36spermatid nucleus differentiation (GO:0007289)4.52080955
37DNA packaging (GO:0006323)4.51788779
38left/right pattern formation (GO:0060972)4.49130810
39chromosome organization involved in meiosis (GO:0070192)4.46440104
40seminiferous tubule development (GO:0072520)4.42801067
41microtubule severing (GO:0051013)4.33009306
42chaperone-mediated protein complex assembly (GO:0051131)4.29687861
43ether metabolic process (GO:0018904)4.26056608
44short-term memory (GO:0007614)4.24682875
45response to pheromone (GO:0019236)4.20263698
46mitotic metaphase plate congression (GO:0007080)4.16373524
47cullin deneddylation (GO:0010388)4.10763534
48meiotic nuclear division (GO:0007126)4.07333332
49genitalia morphogenesis (GO:0035112)3.91821392
50multicellular organismal development (GO:0007275)3.83488889
51DNA double-strand break processing (GO:0000729)3.82098804
52protein heterotetramerization (GO:0051290)3.78593796
53kinetochore assembly (GO:0051382)3.74192808
54meiosis I (GO:0007127)3.72259272
55positive regulation of mitochondrial fission (GO:0090141)3.68205257
56sequestering of actin monomers (GO:0042989)3.66919415
57metaphase plate congression (GO:0051310)3.65492694
58protein deneddylation (GO:0000338)3.65347715
59DNA strand renaturation (GO:0000733)3.63305419
60histone H2A acetylation (GO:0043968)3.58289431
61microtubule polymerization or depolymerization (GO:0031109)3.57411610
62maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.56385799
63regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.54945167
64single strand break repair (GO:0000012)3.54919564
65centriole replication (GO:0007099)3.52855347
66nuclear pore complex assembly (GO:0051292)3.48082063
67sexual reproduction (GO:0019953)3.46785889
68regulation of mitotic spindle organization (GO:0060236)3.45511466
69meiotic cell cycle (GO:0051321)3.41310747
70RNA localization (GO:0006403)3.35949465
71protein polyglutamylation (GO:0018095)3.32905111
72protein localization to cilium (GO:0061512)3.32280329
73regulation of spindle checkpoint (GO:0090231)3.26210532
74regulation of spindle organization (GO:0090224)3.21630175
75amino-acid betaine transport (GO:0015838)3.20372247
76carnitine transport (GO:0015879)3.20372247
77mRNA cleavage (GO:0006379)3.14993409
78polyol catabolic process (GO:0046174)3.13834077
79kinetochore organization (GO:0051383)3.13789407
80interferon-gamma secretion (GO:0072643)3.13661005
81DNA catabolic process, exonucleolytic (GO:0000738)3.13384161
82glycolytic process (GO:0006096)3.13106785
83mitotic sister chromatid cohesion (GO:0007064)3.12791048
84regulation of centrosome cycle (GO:0046605)3.12440077
85nuclear pore organization (GO:0006999)3.11794916
86protein refolding (GO:0042026)3.11370783
87regulation of centrosome duplication (GO:0010824)3.07748566
88DNA damage response, detection of DNA damage (GO:0042769)3.05695315
89establishment of chromosome localization (GO:0051303)3.05509029
90carnitine transmembrane transport (GO:1902603)3.04898000
91negative regulation of DNA-dependent DNA replication (GO:2000104)3.03810310
92ubiquinone biosynthetic process (GO:0006744)3.01333265
93pyrimidine nucleobase catabolic process (GO:0006208)2.99752480
94nucleus organization (GO:0006997)2.97126735
95tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.94901102
96RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.94901102
97G-protein coupled receptor internalization (GO:0002031)2.94502829
98chromatin remodeling at centromere (GO:0031055)2.94166169
99pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)2.92880959
100UMP metabolic process (GO:0046049)2.92880959
101pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)2.92880959
102UMP biosynthetic process (GO:0006222)2.92880959
103somatic diversification of immune receptors via somatic mutation (GO:0002566)2.92801408
104somatic hypermutation of immunoglobulin genes (GO:0016446)2.92801408
105N-terminal protein amino acid acetylation (GO:0006474)2.91486802
106ribonucleoprotein complex disassembly (GO:0032988)2.91294345
107regulation of centriole replication (GO:0046599)2.91230840
108microtubule nucleation (GO:0007020)2.90698872
109protein K11-linked deubiquitination (GO:0035871)2.89912674
110mitotic sister chromatid segregation (GO:0000070)2.89664003
111alditol metabolic process (GO:0019400)2.87585366
112L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.86590348
113microtubule-based movement (GO:0007018)2.85821143
114purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)2.85062373
115negative regulation of organelle assembly (GO:1902116)2.84210733
116nucleoside diphosphate phosphorylation (GO:0006165)2.83238488
117lactate metabolic process (GO:0006089)2.82992820
118mitotic nuclear envelope disassembly (GO:0007077)2.82918911
119histone exchange (GO:0043486)2.81124710
120lipopolysaccharide biosynthetic process (GO:0009103)2.79024046
121RNA destabilization (GO:0050779)2.75605153
122regulation of nuclear cell cycle DNA replication (GO:0033262)2.75437148
123recombinational repair (GO:0000725)2.74464399
124pore complex assembly (GO:0046931)2.74332145
125sister chromatid segregation (GO:0000819)2.73691746
126regulation of cilium assembly (GO:1902017)2.73085956
127ubiquinone metabolic process (GO:0006743)2.72653413
128positive regulation of macrophage activation (GO:0043032)2.72550155
129positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003572.72387891
130mitochondrial fission (GO:0000266)2.71449892
131resolution of meiotic recombination intermediates (GO:0000712)2.71299883
132apoptotic DNA fragmentation (GO:0006309)2.65969814
133intraciliary transport (GO:0042073)2.65521362
1347-methylguanosine mRNA capping (GO:0006370)2.64989736
135synapsis (GO:0007129)2.64813275
136CENP-A containing nucleosome assembly (GO:0034080)2.64778653
137meiotic cell cycle process (GO:1903046)2.64283299
138regulation of mitochondrial fission (GO:0090140)2.64233882
139cilium morphogenesis (GO:0060271)2.63546535
140telomere maintenance via semi-conservative replication (GO:0032201)2.62479982
141deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.62277968
142double-strand break repair via homologous recombination (GO:0000724)2.60280463
143cilium organization (GO:0044782)2.60035495
144GTP biosynthetic process (GO:0006183)2.58732149
1457-methylguanosine RNA capping (GO:0009452)2.56733583
146RNA capping (GO:0036260)2.56733583
147gene silencing by RNA (GO:0031047)2.54720806
148nuclear envelope disassembly (GO:0051081)2.54420706
149membrane disassembly (GO:0030397)2.54420706
150axoneme assembly (GO:0035082)2.53641296
151membrane protein intracellular domain proteolysis (GO:0031293)2.53493673
152cellular component assembly involved in morphogenesis (GO:0010927)2.52785044
153rRNA modification (GO:0000154)2.52227091
154sex differentiation (GO:0007548)2.51398616
155ventricular cardiac muscle cell development (GO:0055015)2.50832576
156organelle disassembly (GO:1903008)2.49317538
157microtubule bundle formation (GO:0001578)2.49232566
158establishment of mitochondrion localization (GO:0051654)2.48500944
159photoreceptor cell maintenance (GO:0045494)2.48476988
160cilium assembly (GO:0042384)2.47888726
161peptidyl-glutamic acid modification (GO:0018200)2.47656636
162DNA catabolic process, endonucleolytic (GO:0000737)2.47296594
163glycine metabolic process (GO:0006544)2.46985268
164deoxyribonucleotide biosynthetic process (GO:0009263)2.46933870
165RNA phosphodiester bond hydrolysis, endonucleolytic (GO:0090502)2.46047967
166ncRNA catabolic process (GO:0034661)2.45566932
167establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.43671858
168mitochondrion transport along microtubule (GO:0047497)2.43671858
169L-methionine salvage (GO:0071267)2.43474959
170L-methionine biosynthetic process (GO:0071265)2.43474959
171amino acid salvage (GO:0043102)2.43474959
172glycerol metabolic process (GO:0006071)2.42398953
173multicellular organismal aging (GO:0010259)2.41622349
174pseudouridine synthesis (GO:0001522)2.41448038
175calcium ion import (GO:0070509)2.41404024
176regulation of chromosome segregation (GO:0051983)2.41385825
177spindle checkpoint (GO:0031577)2.41278981
178cellular response to arsenic-containing substance (GO:0071243)2.40632036
179negative regulation of mitotic sister chromatid segregation (GO:0033048)2.40516529
180sperm motility (GO:0030317)14.0783157
181fusion of sperm to egg plasma membrane (GO:0007342)13.1131226
182acrosome reaction (GO:0007340)12.2705790
183cell wall macromolecule catabolic process (GO:0016998)11.7823403
184cell wall macromolecule metabolic process (GO:0044036)11.7823403
185acrosome assembly (GO:0001675)11.4867071
186sperm-egg recognition (GO:0035036)11.4041161
187multicellular organism reproduction (GO:0032504)10.6582898
188binding of sperm to zona pellucida (GO:0007339)10.4286257
189cell-cell recognition (GO:0009988)10.2094361
190plasma membrane fusion (GO:0045026)10.0822281

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse8.93249267
2E2F7_22180533_ChIP-Seq_HELA_Human5.35071069
3EZH2_22144423_ChIP-Seq_EOC_Human4.99955005
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.42310110
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.12094501
6FOXM1_23109430_ChIP-Seq_U2OS_Human3.89747164
7TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.78710790
8STAT6_21828071_ChIP-Seq_BEAS2B_Human3.47767552
9GABP_17652178_ChIP-ChIP_JURKAT_Human3.47129000
10E2F4_17652178_ChIP-ChIP_JURKAT_Human2.96691996
11GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.90710417
12PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.84361797
13EST1_17652178_ChIP-ChIP_JURKAT_Human2.80962475
14VDR_22108803_ChIP-Seq_LS180_Human2.62189478
15FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.60973196
16CREB1_15753290_ChIP-ChIP_HEK293T_Human2.60591107
17ETS1_20019798_ChIP-Seq_JURKAT_Human2.51592292
18HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.49374128
19BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.31977970
20SALL1_21062744_ChIP-ChIP_HESCs_Human2.31967092
21JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.23437651
22GATA1_26923725_Chip-Seq_HPCs_Mouse2.17587935
23ZNF274_21170338_ChIP-Seq_K562_Hela2.00903306
24ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.99181789
25GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.94874642
26NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.93345720
27EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.92495297
28IGF1R_20145208_ChIP-Seq_DFB_Human1.90790430
29GABP_19822575_ChIP-Seq_HepG2_Human1.85967237
30MYC_18555785_ChIP-Seq_MESCs_Mouse1.85914173
31ELK1_19687146_ChIP-ChIP_HELA_Human1.80544754
32CBP_20019798_ChIP-Seq_JUKART_Human1.78422815
33IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.78422815
34CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.77169087
35FLI1_27457419_Chip-Seq_LIVER_Mouse1.77159696
36CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.75680891
37MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.74182594
38FUS_26573619_Chip-Seq_HEK293_Human1.73379400
39VDR_23849224_ChIP-Seq_CD4+_Human1.71364939
40FOXP3_21729870_ChIP-Seq_TREG_Human1.69124780
41PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.65839088
42ELK4_26923725_Chip-Seq_MESODERM_Mouse1.62838035
43FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.61177117
44CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.57089833
45CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.57051973
46TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.56593554
47TAF15_26573619_Chip-Seq_HEK293_Human1.56074803
48KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.55563723
49MYC_18940864_ChIP-ChIP_HL60_Human1.54962243
50* STAT1_17558387_ChIP-Seq_HELA_Human1.54712944
51KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.52655570
52E2F1_21310950_ChIP-Seq_MCF-7_Human1.52071790
53REST_21632747_ChIP-Seq_MESCs_Mouse1.50346545
54RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.48128471
55FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.47630527
56PADI4_21655091_ChIP-ChIP_MCF-7_Human1.47133292
57KDM2B_26808549_Chip-Seq_REH_Human1.44072789
58GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.43977225
59PCGF2_27294783_Chip-Seq_ESCs_Mouse1.43142047
60YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.42708801
61* SOX2_22085726_ChIP-Seq_NPCs_Mouse1.40924315
62TAL1_26923725_Chip-Seq_HPCs_Mouse1.38937446
63SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.38232536
64MYCN_18555785_ChIP-Seq_MESCs_Mouse1.36463356
65WDR5_24793694_ChIP-Seq_LNCAP_Human1.36009594
66TP63_19390658_ChIP-ChIP_HaCaT_Human1.35596222
67HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.35026120
68MYC_19030024_ChIP-ChIP_MESCs_Mouse1.34819111
69* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.31008685
70CTBP1_25329375_ChIP-Seq_LNCAP_Human1.30675521
71POU3F2_20337985_ChIP-ChIP_501MEL_Human1.30569420
72CBX2_27304074_Chip-Seq_ESCs_Mouse1.30544564
73* GATA3_21867929_ChIP-Seq_CD8_Mouse1.27859748
74AUTS2_25519132_ChIP-Seq_293T-REX_Human1.25960489
75TTF2_22483619_ChIP-Seq_HELA_Human1.25640675
76MYC_18358816_ChIP-ChIP_MESCs_Mouse1.22969662
77DCP1A_22483619_ChIP-Seq_HELA_Human1.22782453
78LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.21053821
79TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.21003593
80* P53_21459846_ChIP-Seq_SAOS-2_Human1.20333320
81LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.19952586
82CTBP2_25329375_ChIP-Seq_LNCAP_Human1.19914407
83MYC_27129775_Chip-Seq_CORNEA_Mouse1.19208385
84GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.19036668
85FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.18637592
86RAD21_21589869_ChIP-Seq_MESCs_Mouse1.18461530
87TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16834762
88KLF5_20875108_ChIP-Seq_MESCs_Mouse1.16452971
89P300_19829295_ChIP-Seq_ESCs_Human1.16449951
90EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.14475283
91SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.14378456
92GF1_26923725_Chip-Seq_HPCs_Mouse1.13865149
93EWS_26573619_Chip-Seq_HEK293_Human1.13451082
94FLI1_21867929_ChIP-Seq_TH2_Mouse1.13181620
95SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.13035932
96CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12699983
97SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.11513359
98SRF_21415370_ChIP-Seq_HL-1_Mouse1.11355574
99KAP1_22055183_ChIP-Seq_ESCs_Mouse1.10852494
100PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.10231722
101NFE2_27457419_Chip-Seq_LIVER_Mouse1.10128545
102PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.10115559
103GATA3_21867929_ChIP-Seq_TH1_Mouse1.08801660
104ERG_20517297_ChIP-Seq_VCAP_Human1.07032972
105PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.06950764
106NANOG_18555785_Chip-Seq_ESCs_Mouse1.05824732
107E2F1_18555785_ChIP-Seq_MESCs_Mouse1.05303379
108CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.03472689
109SUZ12_27294783_Chip-Seq_ESCs_Mouse1.02804870
110MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.02496668
111CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.01622053
112ELF1_17652178_ChIP-ChIP_JURKAT_Human1.01036400
113PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.00729196
114GATA1_19941827_ChIP-Seq_MEL86_Mouse1.00190022
115MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.99707137
116EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.99704706
117RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.99615140
118SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.99223575
119SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.98958292
120NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.98874954
121* POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.98670332
122* TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98670332
123CRX_20693478_ChIP-Seq_RETINA_Mouse0.98111572
124SPI1_26923725_Chip-Seq_HPCs_Mouse0.97720851
125CIITA_25753668_ChIP-Seq_RAJI_Human0.97580728
126THAP11_20581084_ChIP-Seq_MESCs_Mouse0.97333788
127CTCF_20526341_ChIP-Seq_ESCs_Human0.96704137
128SUZ12_27294783_Chip-Seq_NPCs_Mouse0.96555274
129AR_21909140_ChIP-Seq_LNCAP_Human0.96331495
130ESET_19884257_ChIP-Seq_ESCs_Mouse0.96294772
131BCAT_22108803_ChIP-Seq_LS180_Human0.96007408
132SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.95839914
133SMC3_22415368_ChIP-Seq_MEFs_Mouse0.95388526
134KDM5A_27292631_Chip-Seq_BREAST_Human0.94978390
135PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.94316809
136TET1_21451524_ChIP-Seq_MESCs_Mouse0.93660852
137TP53_22573176_ChIP-Seq_HFKS_Human0.93567618
138RXRA_24833708_ChIP-Seq_LIVER_Mouse0.93286469
139CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.92854700
140POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.92485083
141PCGF2_27294783_Chip-Seq_NPCs_Mouse0.92405198
142P53_22387025_ChIP-Seq_ESCs_Mouse0.90952890
143* RNF2_27304074_Chip-Seq_NSC_Mouse0.90660000
144IKZF1_21737484_ChIP-ChIP_HCT116_Human0.89854880
145OCT1_27270436_Chip-Seq_PROSTATE_Human0.89721315
146SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.89327531
147RUNX1_26923725_Chip-Seq_HPCs_Mouse0.89030083
148STAT3_18555785_ChIP-Seq_MESCs_Mouse0.88942679
149STAT3_23295773_ChIP-Seq_U87_Human0.88848110
150MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.88636153
151RBPJ_22232070_ChIP-Seq_NCS_Mouse0.88469498
152ER_23166858_ChIP-Seq_MCF-7_Human0.88152420
153ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.88129754
154KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.88110661
155AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.88104230
156ZFP57_27257070_Chip-Seq_ESCs_Mouse0.87987819
157POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.87868928
158YY1_22570637_ChIP-Seq_MALME-3M_Human0.87362292
159CMYC_18555785_Chip-Seq_ESCs_Mouse0.87315330
160RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.86737464
161TBL1_22424771_ChIP-Seq_293T_Human0.86522731
162CTCF_27219007_Chip-Seq_Bcells_Human0.85396791
163MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.85181072
164OCT4_18555785_Chip-Seq_ESCs_Mouse0.85059427
165JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.85056819
166CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.85009619
167TCF4_22108803_ChIP-Seq_LS180_Human0.84412804
168SMAD4_21799915_ChIP-Seq_A2780_Human0.84210266
169SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.83419567
170FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.83123705
171EZH2_27294783_Chip-Seq_NPCs_Mouse0.79591921
172HOXB4_20404135_ChIP-ChIP_EML_Mouse0.78979086
173NELFA_20434984_ChIP-Seq_ESCs_Mouse0.78760430
174E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.78392967
175NANOG_19829295_ChIP-Seq_ESCs_Human0.77677872

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive5.91191941
2MP0001929_abnormal_gametogenesis5.35785145
3MP0003011_delayed_dark_adaptation4.42613465
4MP0003693_abnormal_embryo_hatching3.86442069
5MP0006292_abnormal_olfactory_placode3.84718766
6MP0008877_abnormal_DNA_methylation3.64734488
7MP0002161_abnormal_fertility/fecundity3.23335806
8MP0002210_abnormal_sex_determination3.16490323
9MP0005670_abnormal_white_adipose3.03592444
10MP0008058_abnormal_DNA_repair2.76306156
11MP0001145_abnormal_male_reproductive2.62421210
12MP0008789_abnormal_olfactory_epithelium2.61373470
13MP0002938_white_spotting2.54520826
14MP0010094_abnormal_chromosome_stability2.45331478
15MP0000653_abnormal_sex_gland2.29296176
16MP0003111_abnormal_nucleus_morphology2.25247062
17MP0002102_abnormal_ear_morphology2.15578314
18MP0005410_abnormal_fertilization16.3834957
19MP0000569_abnormal_digit_pigmentation1.99505820
20MP0008057_abnormal_DNA_replication1.94846471
21MP0003186_abnormal_redox_activity1.93411329
22MP0005499_abnormal_olfactory_system1.88985916
23MP0005394_taste/olfaction_phenotype1.88985916
24MP0010030_abnormal_orbit_morphology1.86221135
25MP0002234_abnormal_pharynx_morphology1.77849997
26MP0004957_abnormal_blastocyst_morpholog1.73035631
27MP0005623_abnormal_meninges_morphology1.65078993
28MP0008932_abnormal_embryonic_tissue1.63295941
29MP0003077_abnormal_cell_cycle1.59267876
30MP0002653_abnormal_ependyma_morphology1.52228605
31MP0002233_abnormal_nose_morphology1.50373118
32MP0003787_abnormal_imprinting1.49126823
33MP0009053_abnormal_anal_canal1.45743749
34MP0002638_abnormal_pupillary_reflex1.41356469
35MP0000372_irregular_coat_pigmentation1.40722614
36MP0005423_abnormal_somatic_nervous1.34965958
37MP0001486_abnormal_startle_reflex1.33821000
38MP0008260_abnormal_autophagy1.32659618
39MP0005647_abnormal_sex_gland1.32413164
40MP0001984_abnormal_olfaction1.29317594
41MP0003646_muscle_fatigue1.28844661
42MP0002282_abnormal_trachea_morphology1.27973802
43MP0004233_abnormal_muscle_weight1.26835517
44MP0000566_synostosis1.25009080
45MP0001853_heart_inflammation1.24854459
46MP0003121_genomic_imprinting1.18116201
47MP0000631_abnormal_neuroendocrine_gland1.17830429
48MP0002160_abnormal_reproductive_system1.17382347
49MP0003195_calcinosis1.17002398
50MP0008875_abnormal_xenobiotic_pharmacok1.16006407
51MP0005645_abnormal_hypothalamus_physiol1.15946321
52MP0001765_abnormal_ion_homeostasis1.15437629
53MP0006036_abnormal_mitochondrial_physio1.15395522
54MP0006035_abnormal_mitochondrial_morpho1.12629037
55MP0009046_muscle_twitch1.11393061
56MP0004215_abnormal_myocardial_fiber1.10759555
57MP0003136_yellow_coat_color1.07432370
58MP0003755_abnormal_palate_morphology1.07121479
59MP0008775_abnormal_heart_ventricle1.00966453
60MP0005451_abnormal_body_composition1.00579465
61MP0000427_abnormal_hair_cycle0.99741824
62MP0008995_early_reproductive_senescence0.96890865
63MP0005171_absent_coat_pigmentation0.95683871
64MP0002932_abnormal_joint_morphology0.95478212
65MP0001697_abnormal_embryo_size0.85924428
66MP0002796_impaired_skin_barrier0.85109085
67MP0002090_abnormal_vision0.84158351
68MP0001905_abnormal_dopamine_level0.84097444
69MP0000647_abnormal_sebaceous_gland0.83313399
70MP0006072_abnormal_retinal_apoptosis0.81324111
71MP0001286_abnormal_eye_development0.77472959
72MP0002095_abnormal_skin_pigmentation0.77288154
73MP0003861_abnormal_nervous_system0.76610701
74MP0005636_abnormal_mineral_homeostasis0.76039920
75MP0002752_abnormal_somatic_nervous0.75341390
76MP0000778_abnormal_nervous_system0.74481860
77MP0004145_abnormal_muscle_electrophysio0.73884203
78MP0002876_abnormal_thyroid_physiology0.73734568
79MP0005395_other_phenotype0.73280204
80MP0006276_abnormal_autonomic_nervous0.73063780
81MP0003941_abnormal_skin_development0.72577236
82MP0003315_abnormal_perineum_morphology0.71331818
83MP0001485_abnormal_pinna_reflex0.70888179
84MP0005174_abnormal_tail_pigmentation0.70825019
85MP0000026_abnormal_inner_ear0.70548400
86MP0001270_distended_abdomen0.70378293
87MP0004133_heterotaxia0.69787822
88MP0002111_abnormal_tail_morphology0.69601704
89MP0010352_gastrointestinal_tract_polyps0.69556953
90MP0000358_abnormal_cell_content/0.68700486
91MP0002085_abnormal_embryonic_tissue0.68242395
92MP0002837_dystrophic_cardiac_calcinosis0.68032718
93MP0003115_abnormal_respiratory_system0.67750332
94MP0003252_abnormal_bile_duct0.67465969
95MP0002184_abnormal_innervation0.67256989
96MP0003786_premature_aging0.65266329
97MP0002152_abnormal_brain_morphology0.64091660
98MP0001529_abnormal_vocalization0.63985942
99MP0003828_pulmonary_edema0.63521188
100MP0003119_abnormal_digestive_system0.63284847
101MP0001849_ear_inflammation0.60746749
102MP0001851_eye_inflammation0.60691468
103MP0004036_abnormal_muscle_relaxation0.59224666
104MP0003699_abnormal_female_reproductive0.58438683
105MP0002736_abnormal_nociception_after0.57524497
106MP0002332_abnormal_exercise_endurance0.57094246
107MP0003329_amyloid_beta_deposits0.54013326
108MP0003879_abnormal_hair_cell0.51206655
109MP0002405_respiratory_system_inflammati0.50997479
110MP0001764_abnormal_homeostasis0.49045370
111MP0000537_abnormal_urethra_morphology0.48044919
112MP0002909_abnormal_adrenal_gland0.47276029
113MP0009379_abnormal_foot_pigmentation0.45520579
114MP0005666_abnormal_adipose_tissue0.45407845
115MP0001968_abnormal_touch/_nociception0.44033886
116MP0003880_abnormal_central_pattern0.42668264
117MP0005389_reproductive_system_phenotype0.42561589
118MP0001293_anophthalmia0.39237097
119MP0001727_abnormal_embryo_implantation0.37500487
120MP0000750_abnormal_muscle_regeneration0.36831426
121MP0005551_abnormal_eye_electrophysiolog0.36126639
122MP0004811_abnormal_neuron_physiology0.35372812
123MP0000604_amyloidosis0.34758684
124MP0003866_abnormal_defecation0.34692528
125MP0005253_abnormal_eye_physiology0.34154016
126MP0003633_abnormal_nervous_system0.33121934
127MP0003950_abnormal_plasma_membrane0.32650500
128MP0002272_abnormal_nervous_system0.32393435
129MP0002572_abnormal_emotion/affect_behav0.32160242
130MP0005391_vision/eye_phenotype0.31557934
131MP0003635_abnormal_synaptic_transmissio0.28945994
132MP0001119_abnormal_female_reproductive0.28718688
133MP0002295_abnormal_pulmonary_circulatio0.28155019
134MP0005397_hematopoietic_system_phenotyp0.27192542
135MP0001545_abnormal_hematopoietic_system0.27192542
136MP0002148_abnormal_hypersensitivity_rea0.26515111
137MP0004019_abnormal_vitamin_homeostasis0.26470419
138MP0003448_altered_tumor_morphology0.26004334
139MP0003942_abnormal_urinary_system0.25093626
140MP0005646_abnormal_pituitary_gland0.25067174
141MP0002092_abnormal_eye_morphology0.24917371
142MP0008569_lethality_at_weaning0.24447443
143MP0005584_abnormal_enzyme/coenzyme_acti0.24276742
144MP0001440_abnormal_grooming_behavior0.24112430
145MP0004270_analgesia0.24082909
146MP0002009_preneoplasia0.23719935
147MP0002063_abnormal_learning/memory/cond0.22836420
148MP0003878_abnormal_ear_physiology0.22620456
149MP0005377_hearing/vestibular/ear_phenot0.22620456
150MP0004510_myositis0.22382709
151MP0000751_myopathy0.21956799
152MP0005187_abnormal_penis_morphology0.21930488
153MP0001324_abnormal_eye_pigmentation0.21859058
154MP0005266_abnormal_metabolism0.21348384
155MP0005535_abnormal_body_temperature0.21137067
156MP0003718_maternal_effect0.20013166
157MP0000920_abnormal_myelination0.19771234
158MP0001502_abnormal_circadian_rhythm0.19532905
159MP0009278_abnormal_bone_marrow0.19471793
160MP0004859_abnormal_synaptic_plasticity0.19160386
161MP0003936_abnormal_reproductive_system0.19078288
162MP0002106_abnormal_muscle_physiology0.18151882
163MP0004087_abnormal_muscle_fiber0.17975710
164MP0002133_abnormal_respiratory_system0.17812129
165MP0005388_respiratory_system_phenotype0.17812129
166MP0000534_abnormal_ureter_morphology0.17354111
167MP0008770_decreased_survivor_rate0.17168483
168MP0004130_abnormal_muscle_cell0.16962281
169MP0002060_abnormal_skin_morphology0.16846100

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.17542566
2Abnormal respiratory epithelium morphology (HP:0012253)8.97963467
3Abnormal respiratory motile cilium morphology (HP:0005938)8.97963467
4Rhinitis (HP:0012384)7.61207615
5Abnormal ciliary motility (HP:0012262)7.12091008
6Chronic bronchitis (HP:0004469)7.09920038
7Infertility (HP:0000789)6.96386955
8Nasal polyposis (HP:0100582)6.18446108
9Abnormality of the nasal mucosa (HP:0000433)5.09265837
10Male infertility (HP:0003251)4.80022591
11Bronchitis (HP:0012387)4.50641533
12Bronchiectasis (HP:0002110)4.38844620
13Nephronophthisis (HP:0000090)3.86512755
14Volvulus (HP:0002580)3.76115623
15Abnormal spermatogenesis (HP:0008669)3.60661210
16Tubulointerstitial nephritis (HP:0001970)3.42371303
17Recurrent sinusitis (HP:0011108)3.35907247
18Oligodactyly (hands) (HP:0001180)3.30270594
19Recurrent otitis media (HP:0000403)3.24185664
20Chromsome breakage (HP:0040012)2.94267944
21Chronic hepatic failure (HP:0100626)2.90389874
22Upper limb muscle weakness (HP:0003484)2.89090229
23Attenuation of retinal blood vessels (HP:0007843)2.88529896
24Gonadotropin excess (HP:0000837)2.87732309
25Abnormality of the renal medulla (HP:0100957)2.87334141
26Metaphyseal dysplasia (HP:0100255)2.85521737
27Recurrent bronchitis (HP:0002837)2.77789197
28Chromosomal breakage induced by crosslinking agents (HP:0003221)2.74841029
29Oligodactyly (HP:0012165)2.74215506
30Abnormality of the labia minora (HP:0012880)2.73022273
31Tubular atrophy (HP:0000092)2.68879213
32Ectopic kidney (HP:0000086)2.66989314
33Tubulointerstitial abnormality (HP:0001969)2.63791404
34Aplasia/Hypoplasia of the uvula (HP:0010293)2.63627305
35Choroideremia (HP:0001139)2.59626959
36Abnormality of the preputium (HP:0100587)2.56255530
37Severe visual impairment (HP:0001141)2.55331598
38Pancreatic cysts (HP:0001737)2.55226505
39Abnormality of the ileum (HP:0001549)2.53643380
40Confusion (HP:0001289)2.53327184
41Abnormality of chromosome stability (HP:0003220)2.53136050
42Meckel diverticulum (HP:0002245)2.52015821
43Azoospermia (HP:0000027)2.50936065
44Pancreatic fibrosis (HP:0100732)2.49429360
45Impulsivity (HP:0100710)2.47373692
46Absent forearm bone (HP:0003953)2.46488689
47Aplasia involving forearm bones (HP:0009822)2.46488689
48Absent radius (HP:0003974)2.45811101
49Cholecystitis (HP:0001082)2.40792397
50Abnormal gallbladder physiology (HP:0012438)2.40792397
51Supernumerary spleens (HP:0009799)2.38577150
52Aplasia/Hypoplasia of the earlobes (HP:0009906)2.34477631
53Microvesicular hepatic steatosis (HP:0001414)2.27695936
54Hepatocellular necrosis (HP:0001404)2.22560850
55Abnormality of the carotid arteries (HP:0005344)2.12195842
56Absent thumb (HP:0009777)2.10795434
57Occipital encephalocele (HP:0002085)2.10549960
58Congenital primary aphakia (HP:0007707)2.09765509
59Molar tooth sign on MRI (HP:0002419)2.04272780
60Abnormality of midbrain morphology (HP:0002418)2.04272780
61Gait imbalance (HP:0002141)2.02425617
62Abnormality of dentin (HP:0010299)2.02271122
63Absent/shortened dynein arms (HP:0200106)13.4252953
64Dynein arm defect of respiratory motile cilia (HP:0012255)13.4252953
65Respiratory insufficiency due to defective ciliary clearance (HP:0200073)12.6428493
66Cupped ear (HP:0000378)1.98798385
67Renal hypoplasia (HP:0000089)1.97538658
68Optic nerve hypoplasia (HP:0000609)1.96577225
69Increased CSF lactate (HP:0002490)1.93599946
70Spastic tetraparesis (HP:0001285)1.92377296
71Increased serum lactate (HP:0002151)1.91836134
72True hermaphroditism (HP:0010459)1.91775618
73Tubulointerstitial fibrosis (HP:0005576)1.91573099
74Carpal bone hypoplasia (HP:0001498)1.89270609
75Adrenal hypoplasia (HP:0000835)1.88852181
76Taurodontia (HP:0000679)1.88208412
77Abnormality of permanent molar morphology (HP:0011071)1.88208412
78Abnormality of the dental root (HP:0006486)1.88208412
79Hemorrhage of the eye (HP:0011885)1.88106404
80Exercise-induced myalgia (HP:0003738)1.87940102
81Hypoplastic pelvis (HP:0008839)1.86190206
82Stage 5 chronic kidney disease (HP:0003774)1.85935741
83Abnormal number of incisors (HP:0011064)1.85873021
84Sloping forehead (HP:0000340)1.85605777
85Renovascular hypertension (HP:0100817)1.85570597
86Medial flaring of the eyebrow (HP:0010747)1.83279762
87Short middle phalanx of the 5th finger (HP:0004220)1.83202209
88Aplasia/Hypoplasia of the tongue (HP:0010295)1.81632689
89Abnormal hair whorl (HP:0010721)1.80915872
90Sensory axonal neuropathy (HP:0003390)1.80388282
91Broad-based gait (HP:0002136)1.79936584
92Anophthalmia (HP:0000528)1.78965738
93Congenital malformation of the right heart (HP:0011723)1.78832323
94Double outlet right ventricle (HP:0001719)1.78832323
95Increased nuchal translucency (HP:0010880)1.78689235
96Abnormality of molar (HP:0011077)1.78491947
97Abnormality of molar morphology (HP:0011070)1.78491947
98Decreased central vision (HP:0007663)1.78210336
99Hemiparesis (HP:0001269)1.77958156
100Aplasia/Hypoplasia of the sternum (HP:0006714)1.77914191
101Dyschromatopsia (HP:0007641)1.76852594
102Preaxial hand polydactyly (HP:0001177)1.75710682
103Astigmatism (HP:0000483)1.75505895
104Hepatic necrosis (HP:0002605)1.74893659
105Duplicated collecting system (HP:0000081)1.74302377
106Abnormality of lateral ventricle (HP:0030047)1.72763085
107Milia (HP:0001056)1.72306688
108Triphalangeal thumb (HP:0001199)1.72154181
109Optic disc pallor (HP:0000543)1.71751419
110Abnormality of the dental pulp (HP:0006479)1.71630890
111Mitochondrial inheritance (HP:0001427)1.71575155
112Neurofibrillary tangles (HP:0002185)1.70523245
113Postaxial foot polydactyly (HP:0001830)1.70486829
114Patent foramen ovale (HP:0001655)1.69939903
115Abnormality of the metopic suture (HP:0005556)1.69476668
116Genital tract atresia (HP:0001827)1.69447532
117Abnormality of the lower motor neuron (HP:0002366)1.69134590
118Overfolded helix (HP:0000396)1.67763076
119Neonatal respiratory distress (HP:0002643)1.67538848
120Birth length less than 3rd percentile (HP:0003561)1.67148571
121Optic nerve coloboma (HP:0000588)1.67032151
122Nephrogenic diabetes insipidus (HP:0009806)1.66524207
123Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.66471968
124Drooling (HP:0002307)1.64955994
125Aganglionic megacolon (HP:0002251)1.64713538
126Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.64681666
127Intellectual disability, moderate (HP:0002342)1.64238128
128Vaginal atresia (HP:0000148)1.64166574
129Holoprosencephaly (HP:0001360)1.63480574
130Poor coordination (HP:0002370)1.63447918
131Tented upper lip vermilion (HP:0010804)1.63343288
132Small intestinal stenosis (HP:0012848)1.62947452
133Duodenal stenosis (HP:0100867)1.62947452
134Decreased testicular size (HP:0008734)1.62786953
135Abnormality of the duodenum (HP:0002246)1.62031296
136Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.61883898
137Esophageal atresia (HP:0002032)1.60722290
138Opisthotonus (HP:0002179)1.60631116
139Anencephaly (HP:0002323)1.59654974
140Patellar aplasia (HP:0006443)1.58266817
141Broad distal phalanx of finger (HP:0009836)1.58243133
142Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.56971946
143Short ribs (HP:0000773)1.55981102
144Abnormal mitochondria in muscle tissue (HP:0008316)1.55739431
145Acute encephalopathy (HP:0006846)1.55228349
146Abnormal drinking behavior (HP:0030082)1.49699728
147Polydipsia (HP:0001959)1.49699728
148Cerebral inclusion bodies (HP:0100314)1.49583108
149Heterotopia (HP:0002282)1.45330536
150Congenital hepatic fibrosis (HP:0002612)1.45123111
151Chronic sinusitis (HP:0011109)1.44671039
152Hypoplasia of the capital femoral epiphysis (HP:0003090)1.44661913
153Abnormality of the renal cortex (HP:0011035)1.42414007
154Facial cleft (HP:0002006)1.41766922
155Renal dysplasia (HP:0000110)1.40841892
156Bell-shaped thorax (HP:0001591)1.39974376
157Short thorax (HP:0010306)1.38781310
158Myoglobinuria (HP:0002913)1.37109825
159Abnormality of renal excretion (HP:0011036)1.35699727
160Bundle branch block (HP:0011710)1.33082481
161Hypoplasia of dental enamel (HP:0006297)1.32430001
162Decreased electroretinogram (ERG) amplitude (HP:0000654)1.31968839
163Postaxial hand polydactyly (HP:0001162)1.31401897
164Absent frontal sinuses (HP:0002688)1.31208184
165Fibular hypoplasia (HP:0003038)1.29577134
166J-shaped sella turcica (HP:0002680)1.28641572
167Oculomotor apraxia (HP:0000657)1.27874620
168Median cleft lip (HP:0000161)1.27488435
169Nephropathy (HP:0000112)1.27314435
170Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.25188410
171Microglossia (HP:0000171)1.24584897
172Neuronal loss in central nervous system (HP:0002529)1.23006412
173Hypoplastic labia majora (HP:0000059)1.22854523
174Short nail (HP:0001799)1.21797925
175Abnormality of the neuromuscular junction (HP:0003398)1.21706896
176Fatigable weakness (HP:0003473)1.21706896
177Amyotrophic lateral sclerosis (HP:0007354)1.21358579
178Decreased motor nerve conduction velocity (HP:0003431)1.16363795
179Aplasia/Hypoplasia of the lens (HP:0008063)1.15157330
180Deformed sella turcica (HP:0002681)1.13890028
181Absent epiphyses (HP:0010577)1.11436014
182Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.11436014
183Abnormal urine output (HP:0012590)1.11206553
184Abnormal biliary tract physiology (HP:0012439)1.11045800
185Bile duct proliferation (HP:0001408)1.11045800
186Easy fatigability (HP:0003388)1.10872431
187Optic neuritis (HP:0100653)1.09527476
188Retrobulbar optic neuritis (HP:0100654)1.09527476

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK37.27822266
2PDK47.27822266
3TESK17.11807212
4TRIM286.10920171
5PRKD35.05898672
6PDK25.01455265
7ICK4.43493986
8PLK43.39583194
9EIF2AK32.70834715
10SIK32.53036144
11PTK2B2.52341290
12NEK12.51412345
13BCR2.48434582
14BUB12.46545509
15WNK42.21458508
16PNCK2.19235924
17STK392.15377249
18MST42.14008522
19CASK2.12850274
20STK382.07210064
21MAP3K32.05026629
22WNK32.03165846
23BRD41.90112252
24MAP4K21.72390695
25MKNK21.67422666
26PLK11.58287574
27BMPR1B1.57704506
28STK161.55296883
29DYRK1B1.42597137
30PDK11.41675219
31ZAK1.37640597
32PIK3CG1.36698961
33PLK21.33552254
34NUAK11.27673320
35ACVR1B1.26445091
36BRAF1.26119020
37RIPK41.23790960
38FLT31.23380445
39MAPK131.22367684
40MKNK11.20797876
41NEK21.18712920
42INSRR1.17178162
43STK31.15005416
44PLK31.11153285
45EIF2AK11.10894557
46STK101.09534579
47AKT31.09331179
48CDC71.05518335
49PBK1.02471418
50PDPK10.99624416
51BCKDK0.97104155
52MAPK150.94586707
53DYRK30.93012709
54WNK10.92623960
55ABL20.90333560
56MAP3K100.87338542
57BLK0.85661823
58AURKB0.82911059
59LATS10.78252116
60TYRO30.78060691
61EPHA40.77243660
62TNIK0.75528189
63STK38L0.75235923
64KSR10.75154794
65SRPK10.75147954
66CAMK1G0.74100081
67STK240.70724328
68IRAK10.70661888
69MAPKAPK50.67899425
70DYRK20.66970960
71MST1R0.65847091
72CLK10.65531451
73TSSK60.61543842
74MAP2K60.60772494
75ERBB30.60746971
76MINK10.59655804
77RPS6KA40.58859886
78FRK0.58809863
79CHEK20.57339425
80DYRK1A0.55580882
81MAPKAPK30.54855355
82CDK140.54666912
83CDK190.53574983
84FER0.52003101
85BRSK10.51878644
86CDK10.51611620
87CDK20.51366865
88PASK0.49074003
89LATS20.48732733
90IRAK20.45711659
91CCNB10.45295834
92EPHB20.45237417
93MAP3K80.44940259
94CDK80.44340032
95PRKCG0.43070210
96CSNK1E0.41098457
97TTK0.41073172
98CDK70.40457785
99MAPK110.40334243
100CSNK1G10.39849419
101NEK60.38418447
102AKT20.38188092
103MAPK140.37631060
104CSNK2A10.37251625
105NME20.37086712
106TGFBR10.37004478
107NTRK20.36544226
108PRKD20.36294380
109EEF2K0.35753491
110PRKCQ0.35446116
111MAP2K70.34963398
112PRKCE0.34899179
113LIMK10.34381550
114NME10.34301700
115ROCK10.34300588
116PAK40.34072736
117PINK10.33737036
118STK110.29837836
119PAK10.27865752
120RPS6KB10.26882122
121CDK60.25850868
122CHEK10.22210104
123ERN10.21265795
124PAK20.20515104
125LMTK20.20355892
126MAP3K50.20150606
127TNK20.19971498
128TESK20.19836396
129ATM0.19803951
130DAPK10.18814971
131NTRK30.18296506
132MAPK70.14691265
133MUSK0.14633317
134CAMKK10.13990811
135CAMK2A0.12794150
136RPS6KA10.12280435
137PRKCZ0.11304489
138ATR0.11054977
139CHUK0.11048077
140MARK20.10522917
141MAPK40.10046147
142MTOR0.09377464
143PRKAA10.09182578
144PDGFRB0.08938248
145PIM10.08297616
146PRKG10.07462973
147MAP3K10.07376226
148PKN10.06474821
149PAK60.06473771
150PRKCA0.06457754
151CDK30.06188906
152PRKACG0.05974650
153FGFR30.05488500
154CDK150.04976508
155CSNK1D0.04772727
156SRC0.04718016
157WEE10.04300561
158PRKCD0.03090660
159GSK3B0.02851447
160CSK0.02807564
161MAPK80.02617943
162CDK180.02567847
163MARK10.02101267
164PRKCB0.01966483
165EPHB10.01878585
166CAMK10.01012956
167CDK11A0.00851383
168GRK70.00579340
169RET0.00455364
170CDK50.00265034

Predicted pathways (KEGG)

RankGene SetZ-score
1Non-homologous end-joining_Homo sapiens_hsa034504.25681937
2Fatty acid biosynthesis_Homo sapiens_hsa000614.08956277
3Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.00089254
4RNA polymerase_Homo sapiens_hsa030203.24133552
5Pyruvate metabolism_Homo sapiens_hsa006202.93025580
6alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.92460038
7Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.92063147
8Linoleic acid metabolism_Homo sapiens_hsa005912.82690267
9Cyanoamino acid metabolism_Homo sapiens_hsa004602.76377562
10Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.68621921
11Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.62467675
12Glucagon signaling pathway_Homo sapiens_hsa049222.61191182
13Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.54934558
14Vitamin B6 metabolism_Homo sapiens_hsa007502.51416383
15DNA replication_Homo sapiens_hsa030302.50967705
16Proteasome_Homo sapiens_hsa030502.50259137
17Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.49631331
18Carbohydrate digestion and absorption_Homo sapiens_hsa049732.38376415
19Pyrimidine metabolism_Homo sapiens_hsa002402.34985140
20Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.32993791
21Mismatch repair_Homo sapiens_hsa034302.28097527
22Homologous recombination_Homo sapiens_hsa034402.24777024
23Propanoate metabolism_Homo sapiens_hsa006402.05829219
24RNA transport_Homo sapiens_hsa030131.95369728
25Amphetamine addiction_Homo sapiens_hsa050311.91827137
26PPAR signaling pathway_Homo sapiens_hsa033201.85659573
27Base excision repair_Homo sapiens_hsa034101.82305423
28Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.80629169
29One carbon pool by folate_Homo sapiens_hsa006701.80153559
30Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.77963284
31Protein export_Homo sapiens_hsa030601.77419013
32Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.74759578
33Oocyte meiosis_Homo sapiens_hsa041141.68992703
34Fatty acid degradation_Homo sapiens_hsa000711.61987512
35Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.59930676
36Mineral absorption_Homo sapiens_hsa049781.58796930
37Basal transcription factors_Homo sapiens_hsa030221.58483159
38Dorso-ventral axis formation_Homo sapiens_hsa043201.57747656
39Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.57407238
40Cardiac muscle contraction_Homo sapiens_hsa042601.57252861
41Renin secretion_Homo sapiens_hsa049241.57026544
42Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.55884463
43Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.54783500
44Selenocompound metabolism_Homo sapiens_hsa004501.54076583
45Glycerolipid metabolism_Homo sapiens_hsa005611.53149258
46Nitrogen metabolism_Homo sapiens_hsa009101.52689906
47Lysine degradation_Homo sapiens_hsa003101.51766268
48Spliceosome_Homo sapiens_hsa030401.51570756
49Butanoate metabolism_Homo sapiens_hsa006501.49285048
50Long-term potentiation_Homo sapiens_hsa047201.48662810
51Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.45833957
52Phototransduction_Homo sapiens_hsa047441.43159734
53Parkinsons disease_Homo sapiens_hsa050121.42957267
54Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.39394857
55Fatty acid elongation_Homo sapiens_hsa000621.33154855
56beta-Alanine metabolism_Homo sapiens_hsa004101.32562075
57Fructose and mannose metabolism_Homo sapiens_hsa000511.32011106
58RNA degradation_Homo sapiens_hsa030181.27842383
59Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.27346125
60p53 signaling pathway_Homo sapiens_hsa041151.24826495
61Olfactory transduction_Homo sapiens_hsa047401.24526104
62Fatty acid metabolism_Homo sapiens_hsa012121.23654943
63Cell cycle_Homo sapiens_hsa041101.23521329
64Glycerophospholipid metabolism_Homo sapiens_hsa005641.18702629
65Pentose phosphate pathway_Homo sapiens_hsa000301.18432788
66Ether lipid metabolism_Homo sapiens_hsa005651.18192135
67Nucleotide excision repair_Homo sapiens_hsa034201.13718198
68Fat digestion and absorption_Homo sapiens_hsa049751.10735898
69Insulin secretion_Homo sapiens_hsa049111.08669835
70Tryptophan metabolism_Homo sapiens_hsa003801.08595535
71Oxidative phosphorylation_Homo sapiens_hsa001901.08564151
72Steroid biosynthesis_Homo sapiens_hsa001001.08364663
73Carbon metabolism_Homo sapiens_hsa012001.06622700
74Cysteine and methionine metabolism_Homo sapiens_hsa002700.97767622
75Legionellosis_Homo sapiens_hsa051340.97384711
76Arginine and proline metabolism_Homo sapiens_hsa003300.95874539
77Regulation of autophagy_Homo sapiens_hsa041400.95083800
78Glutathione metabolism_Homo sapiens_hsa004800.93552723
79Primary bile acid biosynthesis_Homo sapiens_hsa001200.92714251
80Huntingtons disease_Homo sapiens_hsa050160.92285824
81Basal cell carcinoma_Homo sapiens_hsa052170.91796400
82cGMP-PKG signaling pathway_Homo sapiens_hsa040220.91649993
83Adipocytokine signaling pathway_Homo sapiens_hsa049200.88741400
84Hedgehog signaling pathway_Homo sapiens_hsa043400.86777375
85Biosynthesis of amino acids_Homo sapiens_hsa012300.86680500
86Synaptic vesicle cycle_Homo sapiens_hsa047210.86234528
87Glycosaminoglycan degradation_Homo sapiens_hsa005310.85765437
88Collecting duct acid secretion_Homo sapiens_hsa049660.84716674
89Estrogen signaling pathway_Homo sapiens_hsa049150.84111919
90Salivary secretion_Homo sapiens_hsa049700.82404797
91Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.82397687
92Calcium signaling pathway_Homo sapiens_hsa040200.80914498
93Alzheimers disease_Homo sapiens_hsa050100.80379020
94Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.80119695
95Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.78857005
96Metabolic pathways_Homo sapiens_hsa011000.74693043
97Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.73821927
98Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.72105925
99Central carbon metabolism in cancer_Homo sapiens_hsa052300.70759049
100Ribosome_Homo sapiens_hsa030100.69272717
101Glutamatergic synapse_Homo sapiens_hsa047240.68784937
102Thyroid hormone synthesis_Homo sapiens_hsa049180.68169767
103Caffeine metabolism_Homo sapiens_hsa002320.66867679
104Vascular smooth muscle contraction_Homo sapiens_hsa042700.65763346
105Circadian entrainment_Homo sapiens_hsa047130.63781420
106Antigen processing and presentation_Homo sapiens_hsa046120.63186401
107Chemical carcinogenesis_Homo sapiens_hsa052040.62021324
108Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.61994286
109Phosphatidylinositol signaling system_Homo sapiens_hsa040700.61889374
110B cell receptor signaling pathway_Homo sapiens_hsa046620.61605359
111Salmonella infection_Homo sapiens_hsa051320.60799018
112Pancreatic secretion_Homo sapiens_hsa049720.59248233
113Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.58437591
114Wnt signaling pathway_Homo sapiens_hsa043100.57151170
115Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.56853828
116Cocaine addiction_Homo sapiens_hsa050300.56285810
117Peroxisome_Homo sapiens_hsa041460.56195694
118Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.55631332
119Nicotine addiction_Homo sapiens_hsa050330.54846464
120VEGF signaling pathway_Homo sapiens_hsa043700.54524601
121Bile secretion_Homo sapiens_hsa049760.54008165
122Gastric acid secretion_Homo sapiens_hsa049710.53875843
123Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.53451154
124Inositol phosphate metabolism_Homo sapiens_hsa005620.52222640
125Retinol metabolism_Homo sapiens_hsa008300.52184652
1262-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.52163640
127Purine metabolism_Homo sapiens_hsa002300.49806238
128Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.49600756
129Drug metabolism - other enzymes_Homo sapiens_hsa009830.49480142
130Graft-versus-host disease_Homo sapiens_hsa053320.49049130
131Toxoplasmosis_Homo sapiens_hsa051450.47832376
132Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.47580927
133Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.45902022
134Taste transduction_Homo sapiens_hsa047420.44318836
135cAMP signaling pathway_Homo sapiens_hsa040240.44195585
136Protein digestion and absorption_Homo sapiens_hsa049740.43628415
137Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.42480352
138mRNA surveillance pathway_Homo sapiens_hsa030150.41009835
139Type I diabetes mellitus_Homo sapiens_hsa049400.40788868
140Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.40782862
141Arachidonic acid metabolism_Homo sapiens_hsa005900.40649601
142Circadian rhythm_Homo sapiens_hsa047100.39207353
143Thyroid hormone signaling pathway_Homo sapiens_hsa049190.37672859
144Pentose and glucuronate interconversions_Homo sapiens_hsa000400.37526410
145Hippo signaling pathway_Homo sapiens_hsa043900.37458324
146Type II diabetes mellitus_Homo sapiens_hsa049300.37187024
147Endocytosis_Homo sapiens_hsa041440.33918040
148Oxytocin signaling pathway_Homo sapiens_hsa049210.31214105
149ABC transporters_Homo sapiens_hsa020100.30921435
150SNARE interactions in vesicular transport_Homo sapiens_hsa041300.30338696
151Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.28745104
152AMPK signaling pathway_Homo sapiens_hsa041520.28731495
153Aldosterone synthesis and secretion_Homo sapiens_hsa049250.28549437
154Shigellosis_Homo sapiens_hsa051310.28513998
155Renin-angiotensin system_Homo sapiens_hsa046140.28123365
156Fanconi anemia pathway_Homo sapiens_hsa034600.26935523
157Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.26441886
158Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.26071394
159Morphine addiction_Homo sapiens_hsa050320.25521572
160Dopaminergic synapse_Homo sapiens_hsa047280.24096791
161Amoebiasis_Homo sapiens_hsa051460.23779279
162Insulin resistance_Homo sapiens_hsa049310.22595849
163Steroid hormone biosynthesis_Homo sapiens_hsa001400.22374584
164Epstein-Barr virus infection_Homo sapiens_hsa051690.22244122
165Measles_Homo sapiens_hsa051620.19192749

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