ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	keratan sulfate catabolic process (GO:0042340)	6.84141933
2	protein heterotrimerization (GO:0070208)	6.52562515
3	peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)	5.59770410
4	extracellular fibril organization (GO:0043206)	5.58152674
5	cell migration involved in heart development (GO:0060973)	5.50955895
6	low-density lipoprotein particle clearance (GO:0034383)	4.89131589
7	fibril organization (GO:0097435)	4.82618759
8	triglyceride catabolic process (GO:0019433)	4.57723462
9	regulation of sequestering of triglyceride (GO:0010889)	4.30317543
10	collagen fibril organization (GO:0030199)	4.09791845
11	barbed-end actin filament capping (GO:0051016)	4.03695744
12	neutral lipid catabolic process (GO:0046461)	4.03378432
13	acylglycerol catabolic process (GO:0046464)	4.03378432
14	extracellular matrix assembly (GO:0085029)	3.96903218
15	regulation of plasminogen activation (GO:0010755)	3.96403236
16	negative regulation of cartilage development (GO:0061037)	3.90147714
17	adhesion of symbiont to host cell (GO:0044650)	3.88433007
18	virion attachment to host cell (GO:0019062)	3.88433007
19	ovulation from ovarian follicle (GO:0001542)	3.81185103
20	regulation of gonadotropin secretion (GO:0032276)	3.65251809
21	transcytosis (GO:0045056)	3.50882575
22	protein localization to cell surface (GO:0034394)	3.49093475
23	kidney mesenchyme development (GO:0072074)	3.41035694
24	negative regulation of smooth muscle cell migration (GO:0014912)	3.40624332
25	metanephric mesenchyme development (GO:0072075)	3.40190155
26	retina vasculature morphogenesis in camera-type eye (GO:0061299)	3.32025375
27	adhesion of symbiont to host (GO:0044406)	3.29973859
28	cellular response to vitamin (GO:0071295)	3.29017028
29	endocrine hormone secretion (GO:0060986)	3.28934613
30	response to dietary excess (GO:0002021)	3.25048240
31	regulation of integrin-mediated signaling pathway (GO:2001044)	3.24068214
32	glomerular filtration (GO:0003094)	3.20834056
33	cartilage development involved in endochondral bone morphogenesis (GO:0060351)	3.17945281
34	cellular response to vascular endothelial growth factor stimulus (GO:0035924)	3.16050227
35	negative regulation of homotypic cell-cell adhesion (GO:0034111)	3.16024712
36	type B pancreatic cell proliferation (GO:0044342)	3.15338460
37	vascular endothelial growth factor signaling pathway (GO:0038084)	3.14164090
38	dermatan sulfate biosynthetic process (GO:0030208)	3.05272117
39	endothelium development (GO:0003158)	3.05058670
40	cGMP-mediated signaling (GO:0019934)	3.04122933
41	basement membrane organization (GO:0071711)	3.03663122
42	dermatan sulfate metabolic process (GO:0030205)	2.97233001
43	apoptotic cell clearance (GO:0043277)	2.95676272
44	positive regulation of fat cell differentiation (GO:0045600)	2.94648753
45	positive regulation of macrophage derived foam cell differentiation (GO:0010744)	2.82992743
46	renal filtration (GO:0097205)	2.82956805
47	cell proliferation involved in metanephros development (GO:0072203)	2.82679314
48	negative regulation of smooth muscle cell proliferation (GO:0048662)	2.81705549
49	positive regulation of catecholamine secretion (GO:0033605)	2.81697865
50	positive regulation of receptor recycling (GO:0001921)	2.81519920
51	positive regulation of vasculogenesis (GO:2001214)	2.81419100
52	negative regulation of platelet activation (GO:0010544)	2.77648841
53	sequestering of extracellular ligand from receptor (GO:0035581)	2.77268495
54	glycerolipid catabolic process (GO:0046503)	2.77167543
55	cellular response to epinephrine stimulus (GO:0071872)	2.75374131
56	negative regulation of protein autophosphorylation (GO:0031953)	2.74721713
57	positive regulation of endothelial cell apoptotic process (GO:2000353)	2.70611552
58	lipid storage (GO:0019915)	2.70575657
59	blood vessel maturation (GO:0001955)	2.70551612
60	negative regulation of nitric-oxide synthase activity (GO:0051001)	2.69806420
61	positive regulation of cellular response to insulin stimulus (GO:1900078)	2.68531958
62	protein trimerization (GO:0070206)	2.67010114
63	endodermal cell differentiation (GO:0035987)	2.66749422
64	regulation of calcineurin-NFAT signaling cascade (GO:0070884)	2.66591782
65	positive regulation of glomerulus development (GO:0090193)	2.65977173
66	negative regulation of cardiac muscle tissue growth (GO:0055022)	2.64596523
67	negative regulation of heart growth (GO:0061117)	2.64596523
68	negative regulation of BMP signaling pathway (GO:0030514)	2.64037674
69	sulfur compound catabolic process (GO:0044273)	2.63333361
70	phagocytosis, recognition (GO:0006910)	2.63247967
71	negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)	2.62538407
72	glycosaminoglycan catabolic process (GO:0006027)	2.62363375
73	stress fiber assembly (GO:0043149)	2.61987137
74	negative regulation of nitric oxide biosynthetic process (GO:0045019)	2.60950009
75	brown fat cell differentiation (GO:0050873)	2.60806968
76	endothelial cell morphogenesis (GO:0001886)	2.60604276
77	diacylglycerol metabolic process (GO:0046339)	2.60539689
78	keratan sulfate biosynthetic process (GO:0018146)	2.59761388
79	white fat cell differentiation (GO:0050872)	2.59550168
80	positive regulation of triglyceride lipase activity (GO:0061365)	2.59336493
81	positive regulation of lipoprotein lipase activity (GO:0051006)	2.59336493
82	negative regulation of gluconeogenesis (GO:0045721)	2.59143546
83	chondroitin sulfate catabolic process (GO:0030207)	2.57281913
84	regulation of macrophage derived foam cell differentiation (GO:0010743)	2.55922568
85	angiogenesis involved in wound healing (GO:0060055)	2.55367253
86	negative regulation of granulocyte differentiation (GO:0030853)	2.55275248
87	regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)	2.53340161
88	positive regulation of odontogenesis (GO:0042482)	2.52327148
89	extracellular matrix organization (GO:0030198)	2.50376025
90	extracellular structure organization (GO:0043062)	2.49447622
91	ethanol oxidation (GO:0006069)	2.49402456
92	regulation of cholesterol storage (GO:0010885)	2.49036552
93	tooth mineralization (GO:0034505)	2.48940630
94	regulation of vascular endothelial growth factor signaling pathway (GO:1900746)	2.47969357
95	keratan sulfate metabolic process (GO:0042339)	2.46112012
96	regulation of cell migration involved in sprouting angiogenesis (GO:0090049)	2.45895582
97	polyol transport (GO:0015791)	2.45268747
98	negative regulation of endothelial cell proliferation (GO:0001937)	2.44527486
99	positive regulation of metanephros development (GO:0072216)	2.43888911
100	negative regulation of vascular permeability (GO:0043116)	2.42582113

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TRIM28_21343339_ChIP-Seq_HEK293_Human	5.25185810
2	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	4.91687224
3	RARG_19884340_ChIP-ChIP_MEFs_Mouse	4.89246994
4	PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse	4.14360984
5	TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	3.01580921
6	CLOCK_20551151_ChIP-Seq_293T_Human	2.77849533
7	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	2.75688577
8	ESR1_22446102_ChIP-Seq_UTERUS_Mouse	2.54808250
9	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	2.44682926
10	CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse	2.29375483
11	RUNX2_24764292_ChIP-Seq_MC3T3_Mouse	2.26793649
12	EED_16625203_ChIP-ChIP_MESCs_Mouse	2.25835305
13	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	2.02781340
14	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.93038457
15	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.88355573
16	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.88355573
17	* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse	1.86369508
18	EP300_21415370_ChIP-Seq_HL-1_Mouse	1.83948390
19	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.82198783
20	* CJUN_26792858_Chip-Seq_BT549_Human	1.78830298
21	ELK3_25401928_ChIP-Seq_HUVEC_Human	1.77473802
22	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.74980884
23	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.70998443
24	SMC3_22415368_ChIP-Seq_MEFs_Mouse	1.68094663
25	SMC1_22415368_ChIP-Seq_MEFs_Mouse	1.64265077
26	MTF2_20144788_ChIP-Seq_MESCs_Mouse	1.62934753
27	SA1_22415368_ChIP-Seq_MEFs_Mouse	1.62271184
28	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	1.62125155
29	GATA2_21666600_ChIP-Seq_HMVEC_Human	1.60476958
30	TBX20_22328084_ChIP-Seq_HEART_Mouse	1.58558952
31	TBX20_22080862_ChIP-Seq_HEART_Mouse	1.58558952
32	EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse	1.56994371
33	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.56753858
34	RXR_22158963_ChIP-Seq_LIVER_Mouse	1.52478201
35	ESR2_21235772_ChIP-Seq_MCF-7_Human	1.52407880
36	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	1.51692337
37	NFIB_24661679_ChIP-Seq_LUNG_Mouse	1.50927336
38	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	1.44827225
39	RAD21_21589869_ChIP-Seq_MESCs_Mouse	1.43378994
40	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.43323218
41	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	1.42219328
42	LXR_22292898_ChIP-Seq_THP-1_Human	1.41157683
43	TP53_20018659_ChIP-ChIP_R1E_Mouse	1.37867189
44	WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse	1.35819333
45	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.31664542
46	PPARG_20176806_ChIP-Seq_3T3-L1_Mouse	1.29199128
47	SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	1.27474020
48	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.25140294
49	PPARA_22158963_ChIP-Seq_LIVER_Mouse	1.24309184
50	PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse	1.23993608
51	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.21774351
52	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	1.21187984
53	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.21108557
54	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.19338495
55	LXR_22158963_ChIP-Seq_LIVER_Mouse	1.18341223
56	* DNAJC2_21179169_ChIP-ChIP_NT2_Human	1.14289520
57	KDM2B_26808549_Chip-Seq_SUP-B15_Human	1.14126595
58	BRD4_25478319_ChIP-Seq_HGPS_Human	1.13676664
59	PPARG_20887899_ChIP-Seq_3T3-L1_Mouse	1.12134674
60	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.11309489
61	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	1.07366763
62	TP63_17297297_ChIP-ChIP_HaCaT_Human	1.04923307
63	* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human	1.04669265
64	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.03537419
65	* P63_26484246_Chip-Seq_KERATINOCYTES_Human	1.03108825
66	* CTCF_27219007_Chip-Seq_Bcells_Human	1.02293026
67	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.00967652
68	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.00363978
69	* PPAR_26484153_Chip-Seq_NCI-H1993_Human	0.99851802
70	ERG_21242973_ChIP-ChIP_JURKAT_Human	0.98459077
71	JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	0.96961558
72	NRF2_20460467_ChIP-Seq_MEFs_Mouse	0.95601545
73	NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	0.95601545
74	JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	0.94793645
75	NR3C1_23031785_ChIP-Seq_PC12_Mouse	0.94285018
76	SA1_27219007_Chip-Seq_ERYTHROID_Human	0.94148195
77	WT1_25993318_ChIP-Seq_PODOCYTE_Human	0.93330386
78	SUZ12_27294783_Chip-Seq_ESCs_Mouse	0.92605097
79	RNF2_27304074_Chip-Seq_ESCs_Mouse	0.91950564
80	RACK7_27058665_Chip-Seq_MCF-7_Human	0.91675230
81	SOX9_24532713_ChIP-Seq_HFSC_Mouse	0.90287789
82	KDM2B_26808549_Chip-Seq_K562_Human	0.90229357
83	SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	0.89351712
84	TP53_23651856_ChIP-Seq_MEFs_Mouse	0.88120909
85	CSB_26484114_Chip-Seq_FIBROBLAST_Human	0.86082596
86	JARID2_20064375_ChIP-Seq_MESCs_Mouse	0.85024306
87	RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human	0.84220724
88	STAT3_19079543_ChIP-ChIP_MESCs_Mouse	0.81111057
89	HIF1A_21447827_ChIP-Seq_MCF-7_Human	0.81090414
90	NR1I2_20693526_ChIP-Seq_LIVER_Mouse	0.78857009
91	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	0.78716040
92	ESR1_21235772_ChIP-Seq_MCF-7_Human	0.78212875
93	ATF3_23680149_ChIP-Seq_GBM1-GSC_Human	0.78121280
94	SMC4_20622854_ChIP-Seq_HELA_Human	0.77085030
95	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.75511358
96	* CTCF_27219007_Chip-Seq_ERYTHROID_Human	0.75441459
97	RING1B_27294783_Chip-Seq_ESCs_Mouse	0.73586455
98	MYC_27129775_Chip-Seq_CORNEA_Mouse	0.71327192
99	DROSHA_22980978_ChIP-Seq_HELA_Human	0.70295427
100	* SA1_27219007_Chip-Seq_Bcells_Human	0.70271754

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008438_abnormal_cutaneous_collagen	6.83005121
2	MP0005503_abnormal_tendon_morphology	6.77135500
3	MP0005275_abnormal_skin_tensile	5.49823750
4	MP0005670_abnormal_white_adipose	3.78830429
5	MP0001958_emphysema	3.39195364
6	MP0003279_aneurysm	3.23918270
7	MP0003705_abnormal_hypodermis_morpholog	2.96144405
8	MP0002108_abnormal_muscle_morphology	2.91458001
9	MP0000751_myopathy	2.79853188
10	MP0004272_abnormal_basement_membrane	2.75502194
11	MP0003011_delayed_dark_adaptation	2.56146164
12	MP0005666_abnormal_adipose_tissue	2.26040939
13	MP0002933_joint_inflammation	2.17852139
14	MP0004130_abnormal_muscle_cell	2.11187968
15	MP0001542_abnormal_bone_strength	2.05231939
16	MP0002295_abnormal_pulmonary_circulatio	1.98874140
17	MP0010368_abnormal_lymphatic_system	1.95688220
18	MP0003724_increased_susceptibility_to	1.95467374
19	MP0009384_cardiac_valve_regurgitation	1.94937972
20	MP0005375_adipose_tissue_phenotype	1.94683671
21	MP0002971_abnormal_brown_adipose	1.91325592
22	MP0005508_abnormal_skeleton_morphology	1.87953750
23	MP0000767_abnormal_smooth_muscle	1.69383763
24	MP0001879_abnormal_lymphatic_vessel	1.55094627
25	MP0005595_abnormal_vascular_smooth	1.55067978
26	MP0006138_congestive_heart_failure	1.50186392
27	MP0003828_pulmonary_edema	1.49081357
28	MP0006054_spinal_hemorrhage	1.48195430
29	MP0000003_abnormal_adipose_tissue	1.46426256
30	MP0002060_abnormal_skin_morphology	1.44866843
31	MP0000343_altered_response_to	1.36686251
32	MP0000013_abnormal_adipose_tissue	1.36578163
33	MP0000749_muscle_degeneration	1.36411839
34	MP0003950_abnormal_plasma_membrane	1.32553621
35	MP0005623_abnormal_meninges_morphology	1.28656144
36	MP0005390_skeleton_phenotype	1.26048082
37	MP0005023_abnormal_wound_healing	1.23264201
38	MP0001661_extended_life_span	1.22622578
39	MP0009115_abnormal_fat_cell	1.22113051
40	MP0005257_abnormal_intraocular_pressure	1.21297781
41	MP0000759_abnormal_skeletal_muscle	1.20003617
42	MP0003186_abnormal_redox_activity	1.19532314
43	MP0004185_abnormal_adipocyte_glucose	1.19049952
44	MP0005164_abnormal_response_to	1.17379336
45	MP0004084_abnormal_cardiac_muscle	1.13773705
46	MP0010030_abnormal_orbit_morphology	1.12930929
47	MP0003959_abnormal_lean_body	1.12147778
48	MP0002876_abnormal_thyroid_physiology	1.07263172
49	MP0000163_abnormal_cartilage_morphology	1.06352284
50	MP0005369_muscle_phenotype	1.05547777
51	MP0001544_abnormal_cardiovascular_syste	1.04369767
52	MP0005385_cardiovascular_system_phenoty	1.04369767
53	MP0004087_abnormal_muscle_fiber	1.03440298
54	MP0000750_abnormal_muscle_regeneration	1.01631225
55	MP0002970_abnormal_white_adipose	1.01077619
56	MP0005620_abnormal_muscle_contractility	1.00094245
57	MP0003566_abnormal_cell_adhesion	0.97511357
58	MP0005167_abnormal_blood-brain_barrier	0.96791492
59	MP0000249_abnormal_blood_vessel	0.96526806
60	MP0002133_abnormal_respiratory_system	0.96506016
61	MP0005388_respiratory_system_phenotype	0.96506016
62	MP0001533_abnormal_skeleton_physiology	0.95977881
63	MP0009780_abnormal_chondrocyte_physiolo	0.95853269
64	MP0010329_abnormal_lipoprotein_level	0.94074955
65	MP0000747_muscle_weakness	0.92997276
66	MP0009250_abnormal_appendicular_skeleto	0.91556069
67	MP0004883_abnormal_blood_vessel	0.91440172
68	MP0003646_muscle_fatigue	0.90966563
69	MP0002972_abnormal_cardiac_muscle	0.86793931
70	MP0002998_abnormal_bone_remodeling	0.86611928
71	MP0004036_abnormal_muscle_relaxation	0.86409704
72	MP0002115_abnormal_skeleton_extremities	0.84553314
73	MP0002896_abnormal_bone_mineralization	0.84544258
74	MP0001243_abnormal_dermal_layer	0.83718175
75	MP0005334_abnormal_fat_pad	0.83402272
76	MP0004858_abnormal_nervous_system	0.81109341
77	MP0003091_abnormal_cell_migration	0.77804458
78	MP0002128_abnormal_blood_circulation	0.76853801
79	MP0003329_amyloid_beta_deposits	0.75426512
80	MP0000230_abnormal_systemic_arterial	0.74912049
81	MP0008775_abnormal_heart_ventricle	0.74210535
82	MP0005165_increased_susceptibility_to	0.70588725
83	MP0002113_abnormal_skeleton_development	0.70435975
84	MP0005330_cardiomyopathy	0.70365649
85	MP0001614_abnormal_blood_vessel	0.70247332
86	MP0005535_abnormal_body_temperature	0.70240642
87	MP0004215_abnormal_myocardial_fiber	0.68407719
88	MP0001299_abnormal_eye_distance/	0.65807794
89	MP0005058_abnormal_lysosome_morphology	0.61570083
90	MP0003191_abnormal_cellular_cholesterol	0.58782645
91	MP0003690_abnormal_glial_cell	0.58244060
92	MP0003448_altered_tumor_morphology	0.57483021
93	MP0005171_absent_coat_pigmentation	0.57382614
94	MP0002127_abnormal_cardiovascular_syste	0.57072369
95	MP0005452_abnormal_adipose_tissue	0.57026303
96	MP0000733_abnormal_muscle_development	0.54822485
97	MP0005647_abnormal_sex_gland	0.54634156
98	MP0002106_abnormal_muscle_physiology	0.54376851
99	MP0000604_amyloidosis	0.52987390
100	MP0009278_abnormal_bone_marrow	0.52474299

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Protrusio acetabuli (HP:0003179)	7.22129416
2	Premature rupture of membranes (HP:0001788)	5.96855497
3	Aortic aneurysm (HP:0004942)	5.69199752
4	Vascular tortuosity (HP:0004948)	4.77535275
5	Aortic dissection (HP:0002647)	4.63714137
6	Soft skin (HP:0000977)	4.45672255
7	Broad metatarsal (HP:0001783)	4.27007063
8	Increased variability in muscle fiber diameter (HP:0003557)	4.11339335
9	Type 1 muscle fiber predominance (HP:0003803)	4.05382847
10	Bladder diverticulum (HP:0000015)	3.90189499
11	Complement deficiency (HP:0004431)	3.80298471
12	Arterial tortuosity (HP:0005116)	3.72028737
13	Joint stiffness (HP:0001387)	3.69112148
14	Pulmonary artery stenosis (HP:0004415)	3.65500858
15	Spinal rigidity (HP:0003306)	3.63801013
16	Shallow orbits (HP:0000586)	3.56921406
17	Ankle contracture (HP:0006466)	3.55479177
18	Dilatation of the ascending aorta (HP:0005111)	3.52755565
19	Abnormality of complement system (HP:0005339)	3.51377963
20	Systemic lupus erythematosus (HP:0002725)	3.49843714
21	Vertebral compression fractures (HP:0002953)	3.48726050
22	Abnormality of skeletal muscle fiber size (HP:0012084)	3.47336098
23	Oligomenorrhea (HP:0000876)	3.26771698
24	Acanthosis nigricans (HP:0000956)	3.26350654
25	Round ear (HP:0100830)	3.24233125
26	Wormian bones (HP:0002645)	3.21845753
27	Increased connective tissue (HP:0009025)	3.14930795
28	Cerebral aneurysm (HP:0004944)	3.11442858
29	Aortic valve stenosis (HP:0001650)	3.07790236
30	Wrist flexion contracture (HP:0001239)	3.07075942
31	Genu recurvatum (HP:0002816)	3.04954593
32	Cervical subluxation (HP:0003308)	3.04519007
33	Ectopia lentis (HP:0001083)	3.04069534
34	Follicular hyperkeratosis (HP:0007502)	2.98868459
35	Slender build (HP:0001533)	2.95732038
36	Ulnar deviation of the wrist (HP:0003049)	2.91858058
37	Blue sclerae (HP:0000592)	2.90886516
38	Muscle fiber splitting (HP:0003555)	2.84204595
39	Hypertriglyceridemia (HP:0002155)	2.77904964
40	Atrophic scars (HP:0001075)	2.66875374
41	Biconcave vertebral bodies (HP:0004586)	2.65225303
42	Aortic regurgitation (HP:0001659)	2.64785494
43	Mitral valve prolapse (HP:0001634)	2.63704737
44	Fragile skin (HP:0001030)	2.63702107
45	Joint laxity (HP:0001388)	2.53029979
46	Peritonitis (HP:0002586)	2.51681278
47	Overgrowth (HP:0001548)	2.51170835
48	Abnormality of dentin (HP:0010299)	2.48383173
49	Aneurysm (HP:0002617)	2.47664056
50	Ovoid vertebral bodies (HP:0003300)	2.43531520
51	Emphysema (HP:0002097)	2.41038784
52	Striae distensae (HP:0001065)	2.38636660
53	Hyperextensible skin (HP:0000974)	2.35102911
54	Bowel diverticulosis (HP:0005222)	2.33759865
55	Polycythemia (HP:0001901)	2.32127777
56	Turricephaly (HP:0000262)	2.31879983
57	Mitral regurgitation (HP:0001653)	2.31842360
58	Spondylolisthesis (HP:0003302)	2.28949971
59	Mildly elevated creatine phosphokinase (HP:0008180)	2.27183740
60	Bone cyst (HP:0012062)	2.26142874
61	Mitral stenosis (HP:0001718)	2.22920494
62	Broad ribs (HP:0000885)	2.20259352
63	Venous abnormality (HP:0002624)	2.15316432
64	Asymmetric septal hypertrophy (HP:0001670)	2.13525632
65	Coronal craniosynostosis (HP:0004440)	2.11729345
66	Infantile muscular hypotonia (HP:0008947)	2.11128475
67	Osteolytic defects of the hand bones (HP:0009699)	2.11102367
68	Osteolytic defects of the phalanges of the hand (HP:0009771)	2.11102367
69	Abnormal delivery (HP:0001787)	2.11076314
70	Mild short stature (HP:0003502)	2.10107106
71	Thin bony cortex (HP:0002753)	2.10009390
72	Neonatal short-limb short stature (HP:0008921)	2.08185366
73	Venous insufficiency (HP:0005293)	2.06831287
74	Back pain (HP:0003418)	2.06520234
75	Wide anterior fontanel (HP:0000260)	2.01520793
76	Limited hip movement (HP:0008800)	2.00716714
77	Hypoplasia of the iris (HP:0007676)	1.99836347
78	Hyporeflexia of lower limbs (HP:0002600)	1.98608934
79	Axonal loss (HP:0003447)	1.98497731
80	Lipoatrophy (HP:0100578)	1.97124825
81	Reduced subcutaneous adipose tissue (HP:0003758)	1.94869286
82	Redundant skin (HP:0001582)	1.93041234
83	Neck muscle weakness (HP:0000467)	1.90371724
84	Hyperlipoproteinemia (HP:0010980)	1.85720152
85	Persistence of primary teeth (HP:0006335)	1.85128563
86	Myocardial infarction (HP:0001658)	1.81985151
87	Hypercortisolism (HP:0001578)	1.77190901
88	Elbow flexion contracture (HP:0002987)	1.75873622
89	Coxa vara (HP:0002812)	1.75775537
90	Generalized amyotrophy (HP:0003700)	1.75393517
91	Prominent supraorbital ridges (HP:0000336)	1.74783975
92	Hemorrhage of the eye (HP:0011885)	1.74769558
93	Metaphyseal dysplasia (HP:0100255)	1.74731332
94	Abnormality of the costochondral junction (HP:0000919)	1.74729622
95	Patent foramen ovale (HP:0001655)	1.74045316
96	Bell-shaped thorax (HP:0001591)	1.73328374
97	Hip contracture (HP:0003273)	1.73048287
98	Beaking of vertebral bodies (HP:0004568)	1.70512571
99	Abnormality of the anterior chamber (HP:0000593)	1.70329577
100	Abnormal eating behavior (HP:0100738)	1.69841876

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MYLK	4.79056120
2	TGFBR2	4.18775957
3	DDR2	3.61284308
4	EPHB2	3.21302470
5	ERN1	3.12860071
6	TIE1	3.10136113
7	PDGFRA	2.97118385
8	TESK1	2.42635543
9	TRIB3	2.27699301
10	RIPK1	2.11933395
11	GRK5	1.94071727
12	SIK1	1.85274948
13	ABL2	1.78484504
14	ARAF	1.74419501
15	TTN	1.67581157
16	KIT	1.64741436
17	MAPKAPK3	1.59632137
18	MOS	1.59283149
19	PAK2	1.57122695
20	LATS2	1.54399154
21	NEK9	1.45471806
22	MAPK15	1.44614626
23	LIMK1	1.44294583
24	MAP3K6	1.43218507
25	GRK1	1.40949168
26	ILK	1.39801324
27	CDC42BPA	1.39658014
28	PINK1	1.35218964
29	LATS1	1.34413207
30	DAPK3	1.34160675
31	MAPK7	1.28720457
32	ADRBK1	1.28262548
33	CAMK1	1.24307129
34	PDGFRB	1.21413251
35	MAPK12	1.20875584
36	PTK2B	1.20842764
37	PTK2	1.19906829
38	OBSCN	1.15828077
39	TRPM7	1.11032532
40	PIK3CG	1.05314457
41	PRKD2	1.01477166
42	MAPK4	1.01440914
43	TGFBR1	1.01335036
44	PRKAA2	0.94765907
45	PAK4	0.94543434
46	STK38L	0.92917369
47	TYK2	0.92735861
48	PRKD1	0.92116310
49	PRKG2	0.90634900
50	EEF2K	0.89226415
51	EPHB1	0.83417607
52	MAP3K3	0.82116883
53	ROCK1	0.81038511
54	DMPK	0.77513117
55	STK38	0.77400364
56	PKN1	0.75416930
57	CSK	0.72451367
58	PRKG1	0.71762410
59	ROCK2	0.71624006
60	NLK	0.70499701
61	PIM2	0.70455537
62	PRKD3	0.67879245
63	TBK1	0.67804393
64	MAP2K1	0.64926371
65	EPHA3	0.63564600
66	MARK2	0.62567847
67	GSK3A	0.62150186
68	ZAP70	0.60618721
69	BLK	0.59297281
70	RPS6KA2	0.57289107
71	PAK1	0.56447931
72	MAP3K13	0.53089499
73	NTRK1	0.52912666
74	MAPKAPK5	0.52459410
75	PDPK1	0.46587685
76	PAK6	0.46498489
77	CAMK2G	0.45004788
78	MAP3K7	0.43727204
79	MAP2K3	0.43721126
80	GRK7	0.41756484
81	PRKACG	0.41411589
82	FER	0.41017798
83	JAK1	0.40718441
84	MAP3K1	0.39172777
85	MET	0.38541065
86	MARK3	0.38503852
87	MTOR	0.37554179
88	FLT3	0.36339678
89	INSR	0.35716602
90	PKN2	0.35339357
91	JAK3	0.35114331
92	RPS6KC1	0.34041866
93	RPS6KL1	0.34041866
94	MUSK	0.32908020
95	RET	0.32224892
96	MAPK3	0.31736005
97	PRKAA1	0.29200003
98	PRPF4B	0.29079519
99	WNK1	0.28803077
100	LRRK2	0.27621207

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	4.00665093
2	ECM-receptor interaction_Homo sapiens_hsa04512	3.64719821
3	PPAR signaling pathway_Homo sapiens_hsa03320	3.10273277
4	Glycosaminoglycan degradation_Homo sapiens_hsa00531	2.42892941
5	Malaria_Homo sapiens_hsa05144	2.30392226
6	Focal adhesion_Homo sapiens_hsa04510	2.29321567
7	Phenylalanine metabolism_Homo sapiens_hsa00360	2.20371796
8	Cyanoamino acid metabolism_Homo sapiens_hsa00460	2.19951078
9	Complement and coagulation cascades_Homo sapiens_hsa04610	2.03624982
10	Dilated cardiomyopathy_Homo sapiens_hsa05414	1.86848538
11	Vascular smooth muscle contraction_Homo sapiens_hsa04270	1.81903171
12	Glycerolipid metabolism_Homo sapiens_hsa00561	1.81693903
13	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	1.69570134
14	Protein digestion and absorption_Homo sapiens_hsa04974	1.66520814
15	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	1.62316227
16	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.61969192
17	Tyrosine metabolism_Homo sapiens_hsa00350	1.57811886
18	Staphylococcus aureus infection_Homo sapiens_hsa05150	1.56586562
19	Histidine metabolism_Homo sapiens_hsa00340	1.45541076
20	Fatty acid elongation_Homo sapiens_hsa00062	1.43015985
21	Adipocytokine signaling pathway_Homo sapiens_hsa04920	1.42881479
22	Fatty acid degradation_Homo sapiens_hsa00071	1.38580353
23	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.33791350
24	Other glycan degradation_Homo sapiens_hsa00511	1.31531695
25	Glutathione metabolism_Homo sapiens_hsa00480	1.31184273
26	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.31052967
27	Renin-angiotensin system_Homo sapiens_hsa04614	1.30936864
28	AMPK signaling pathway_Homo sapiens_hsa04152	1.26178511
29	AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933	1.21109677
30	Sulfur relay system_Homo sapiens_hsa04122	1.20617712
31	Ovarian steroidogenesis_Homo sapiens_hsa04913	1.20263699
32	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.15582215
33	Renin secretion_Homo sapiens_hsa04924	1.14391144
34	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	1.13339131
35	Amoebiasis_Homo sapiens_hsa05146	1.13271761
36	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	1.09152426
37	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.06509529
38	Pertussis_Homo sapiens_hsa05133	1.06185795
39	Tryptophan metabolism_Homo sapiens_hsa00380	1.05401290
40	PI3K-Akt signaling pathway_Homo sapiens_hsa04151	1.03460803
41	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.99964232
42	Proteoglycans in cancer_Homo sapiens_hsa05205	0.98976446
43	Prion diseases_Homo sapiens_hsa05020	0.95511886
44	Pyruvate metabolism_Homo sapiens_hsa00620	0.93747751
45	beta-Alanine metabolism_Homo sapiens_hsa00410	0.93112562
46	Fat digestion and absorption_Homo sapiens_hsa04975	0.89879864
47	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.89358974
48	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.80094620
49	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.77889771
50	Basal cell carcinoma_Homo sapiens_hsa05217	0.77522620
51	Gap junction_Homo sapiens_hsa04540	0.75540500
52	Regulation of actin cytoskeleton_Homo sapiens_hsa04810	0.73006253
53	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.72817780
54	Phagosome_Homo sapiens_hsa04145	0.71916474
55	Lysosome_Homo sapiens_hsa04142	0.69563828
56	Chemical carcinogenesis_Homo sapiens_hsa05204	0.67339199
57	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.67243631
58	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.66619593
59	Melanogenesis_Homo sapiens_hsa04916	0.65783599
60	Ras signaling pathway_Homo sapiens_hsa04014	0.61247292
61	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.61195737
62	Circadian rhythm_Homo sapiens_hsa04710	0.60629842
63	Melanoma_Homo sapiens_hsa05218	0.59545523
64	Retinol metabolism_Homo sapiens_hsa00830	0.59451596
65	Folate biosynthesis_Homo sapiens_hsa00790	0.59421744
66	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.59354498
67	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.59065094
68	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.58416058
69	Pathways in cancer_Homo sapiens_hsa05200	0.58193219
70	cAMP signaling pathway_Homo sapiens_hsa04024	0.57484131
71	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.57219404
72	Rap1 signaling pathway_Homo sapiens_hsa04015	0.56886437
73	Leukocyte transendothelial migration_Homo sapiens_hsa04670	0.54227163
74	Axon guidance_Homo sapiens_hsa04360	0.53005219
75	Platelet activation_Homo sapiens_hsa04611	0.51628211
76	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.45702259
77	ABC transporters_Homo sapiens_hsa02010	0.45681527
78	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.45375687
79	Insulin resistance_Homo sapiens_hsa04931	0.45016424
80	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.44833196
81	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.44303308
82	Insulin signaling pathway_Homo sapiens_hsa04910	0.41781479
83	Adherens junction_Homo sapiens_hsa04520	0.41768912
84	Sulfur metabolism_Homo sapiens_hsa00920	0.41672203
85	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.40848145
86	Osteoclast differentiation_Homo sapiens_hsa04380	0.40300938
87	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.39647075
88	Calcium signaling pathway_Homo sapiens_hsa04020	0.39033267
89	Propanoate metabolism_Homo sapiens_hsa00640	0.34347800
90	Cocaine addiction_Homo sapiens_hsa05030	0.33401550
91	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.33131104
92	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.32854910
93	Wnt signaling pathway_Homo sapiens_hsa04310	0.30138032
94	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.29257925
95	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.27884893
96	Fatty acid metabolism_Homo sapiens_hsa01212	0.27767583
97	Small cell lung cancer_Homo sapiens_hsa05222	0.27004150
98	Tight junction_Homo sapiens_hsa04530	0.26770598
99	Endocytosis_Homo sapiens_hsa04144	0.26296415
100	Notch signaling pathway_Homo sapiens_hsa04330	0.25781973

PLAC9

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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