PLAT

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes tissue-type plasminogen activator, a secreted serine protease that converts the proenzyme plasminogen to plasmin, a fibrinolytic enzyme. The encoded preproprotein is proteolytically processed by plasmin or trypsin to generate heavy and light chains. These chains associate via disulfide linkages to form the heterodimeric enzyme. This enzyme plays a role in cell migration and tissue remodeling. Increased enzymatic activity causes hyperfibrinolysis, which manifests as excessive bleeding, while decreased activity leads to hypofibrinolysis, which can result in thrombosis or embolism. Alternative splicing of this gene results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of female gonad development (GO:2000194)8.21473280
2glomerular visceral epithelial cell development (GO:0072015)7.86257792
3central nervous system myelination (GO:0022010)7.19805008
4axon ensheathment in central nervous system (GO:0032291)7.19805008
5glomerular epithelial cell development (GO:0072310)7.19251495
6glomerular basement membrane development (GO:0032836)7.18560094
7skin morphogenesis (GO:0043589)5.88199453
8myelination (GO:0042552)5.52299303
9axon ensheathment (GO:0008366)5.52231876
10ensheathment of neurons (GO:0007272)5.52231876
11substrate-dependent cell migration (GO:0006929)5.36081082
12lung vasculature development (GO:0060426)5.34850891
13fatty acid elongation (GO:0030497)5.19745845
14glomerulus development (GO:0032835)5.06345990
15apical protein localization (GO:0045176)4.79379053
16endothelium development (GO:0003158)4.47028481
17asymmetric protein localization (GO:0008105)4.40483692
18regulation of phospholipid biosynthetic process (GO:0071071)4.38172400
19peripheral nervous system axon ensheathment (GO:0032292)4.32978756
20myelination in peripheral nervous system (GO:0022011)4.32978756
21eye photoreceptor cell differentiation (GO:0001754)4.27400236
22photoreceptor cell differentiation (GO:0046530)4.27400236
23endodermal cell differentiation (GO:0035987)4.25603265
24maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.18366811
25Golgi transport vesicle coating (GO:0048200)4.15425426
26COPI coating of Golgi vesicle (GO:0048205)4.15425426
27hemidesmosome assembly (GO:0031581)4.11946924
28protein heterotrimerization (GO:0070208)4.08796309
29protein retention in ER lumen (GO:0006621)4.04802393
30multicellular organism reproduction (GO:0032504)4.03502807
31regulation of acrosome reaction (GO:0060046)4.00902867
32hypotonic response (GO:0006971)4.00289696
33chondrocyte proliferation (GO:0035988)3.98378837
34negative regulation of chondrocyte differentiation (GO:0032331)3.96332157
35positive regulation of astrocyte differentiation (GO:0048711)3.95669019
36protein localization to endosome (GO:0036010)3.92379356
37glycerophospholipid catabolic process (GO:0046475)3.92170486
38peptidyl-tyrosine autophosphorylation (GO:0038083)3.91346534
39type B pancreatic cell proliferation (GO:0044342)3.85792092
40positive regulation of osteoblast proliferation (GO:0033690)3.82796787
41regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.76020961
42lung lobe morphogenesis (GO:0060463)3.75949625
43axon extension involved in axon guidance (GO:0048846)3.72397173
44neuron projection extension involved in neuron projection guidance (GO:1902284)3.72397173
45negative regulation of protein localization to cell surface (GO:2000009)3.71374590
46* muscle cell migration (GO:0014812)3.65653896
47adhesion of symbiont to host cell (GO:0044650)3.64661357
48virion attachment to host cell (GO:0019062)3.64661357
49cholesterol biosynthetic process (GO:0006695)3.60014609
50protein kinase C signaling (GO:0070528)3.57121791
51negative regulation of axon guidance (GO:1902668)3.56397833
52renal filtration (GO:0097205)3.55898132
53myelin maintenance (GO:0043217)3.50128448
54regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)3.49340870
55respiratory tube development (GO:0030323)3.49299564
56negative regulation of neurotransmitter secretion (GO:0046929)3.49115766
57astrocyte development (GO:0014002)3.48958703
58ganglion development (GO:0061548)3.48656476
59cellular response to vitamin D (GO:0071305)3.47520550
60vascular endothelial growth factor signaling pathway (GO:0038084)3.46016320
61wound healing, spreading of epidermal cells (GO:0035313)3.45471366
62membrane tubulation (GO:0097320)3.44642669
63negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.41884472
64endocardial cushion development (GO:0003197)3.40829660
65cell-substrate junction assembly (GO:0007044)3.40104989
66basement membrane organization (GO:0071711)3.40056241
67endothelial cell morphogenesis (GO:0001886)3.34655205
68cellular response to vitamin (GO:0071295)3.32773899
69regulation of axon guidance (GO:1902667)3.27814478
70hyaluronan catabolic process (GO:0030214)3.26991149
71collagen metabolic process (GO:0032963)3.26858899
72negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.26644046
73piRNA metabolic process (GO:0034587)3.25603913
74long-chain fatty acid biosynthetic process (GO:0042759)3.24910916
75positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-3.24346949
76regulation of hypersensitivity (GO:0002883)3.23315580
77barbed-end actin filament capping (GO:0051016)3.21458248
78dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.19789765
79oligodendrocyte differentiation (GO:0048709)3.18693353
80apoptotic cell clearance (GO:0043277)3.16728015
81protein maturation by protein folding (GO:0022417)3.15567778
82reproduction (GO:0000003)3.14474086
83regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.13984697
84collagen fibril organization (GO:0030199)3.13510391
85collagen catabolic process (GO:0030574)3.10353819
86sterol biosynthetic process (GO:0016126)3.09751378
87endothelial cell chemotaxis (GO:0035767)3.07194066
88substrate adhesion-dependent cell spreading (GO:0034446)3.07078250
89positive regulation of blood vessel endothelial cell migration (GO:0043536)3.05978123
90negative regulation of axon extension involved in axon guidance (GO:0048843)3.05590796
91glomerular filtration (GO:0003094)3.05216229
92positive regulation of actin filament depolymerization (GO:0030836)3.04515365
93response to redox state (GO:0051775)3.03348452
94multicellular organismal macromolecule metabolic process (GO:0044259)3.01009866
95extracellular matrix disassembly (GO:0022617)3.00333876
96mammary gland epithelial cell proliferation (GO:0033598)2.99479745
97vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.97517503
98facial nerve structural organization (GO:0021612)2.96792096
99cell migration involved in sprouting angiogenesis (GO:0002042)2.95810798
100amyloid precursor protein metabolic process (GO:0042982)2.95009888
101regulation of axon extension involved in axon guidance (GO:0048841)2.93519142
102response to lipoprotein particle (GO:0055094)2.92643459
103atrioventricular valve morphogenesis (GO:0003181)2.92414070
104substantia nigra development (GO:0021762)2.92014469
105negative regulation of neurotransmitter transport (GO:0051589)2.91597758
106epithelial cell differentiation involved in kidney development (GO:0035850)2.91169186
107DNA methylation involved in gamete generation (GO:0043046)2.90760842
108mesodermal cell differentiation (GO:0048333)2.87620710
109epithelial cell-cell adhesion (GO:0090136)2.87317477
110regulation of smooth muscle cell migration (GO:0014910)2.87273567
111negative regulation of cartilage development (GO:0061037)2.86887896
112regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.85459322
113multicellular organismal catabolic process (GO:0044243)2.84900497
114import into cell (GO:0098657)2.84691738
115negative regulation of axonogenesis (GO:0050771)2.84021658
116smooth muscle tissue development (GO:0048745)2.83659140
117multicellular organismal metabolic process (GO:0044236)2.83079773
118mesenchymal-epithelial cell signaling (GO:0060638)2.81445085
119branching involved in salivary gland morphogenesis (GO:0060445)2.80324493
120isoprenoid biosynthetic process (GO:0008299)2.80220066
121extracellular fibril organization (GO:0043206)2.79688192
122female gamete generation (GO:0007292)2.79013386
123cell adhesion mediated by integrin (GO:0033627)2.78578238
124retina vasculature morphogenesis in camera-type eye (GO:0061299)2.78490714
125organ growth (GO:0035265)2.78336400
126negative regulation of axon extension (GO:0030517)2.77777677
127wound healing, spreading of cells (GO:0044319)2.77716765
128response to hepatocyte growth factor (GO:0035728)2.77627690
129cellular response to hepatocyte growth factor stimulus (GO:0035729)2.77627690
130pericardium development (GO:0060039)2.76647576
131neuron remodeling (GO:0016322)2.76207925
132cytoskeletal anchoring at plasma membrane (GO:0007016)2.75967035
133extracellular matrix assembly (GO:0085029)2.75597749
134sequestering of extracellular ligand from receptor (GO:0035581)2.73805472
135adhesion of symbiont to host (GO:0044406)2.73747459
136negative regulation of reproductive process (GO:2000242)2.72877549
137negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)2.72363841
138lung morphogenesis (GO:0060425)2.71574057
139regulation of meiosis (GO:0040020)2.71365033
140regulation of transforming growth factor beta2 production (GO:0032909)2.71023779
141endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.69782519
142regulation of glomerular filtration (GO:0003093)2.69457545
143heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.68478840
144regulation of acute inflammatory response to antigenic stimulus (GO:0002864)2.68243417
145negative regulation of peptidyl-serine phosphorylation (GO:0033137)2.68118982
146positive regulation of cartilage development (GO:0061036)2.68031728
147adherens junction assembly (GO:0034333)2.67221032
148positive regulation of positive chemotaxis (GO:0050927)2.67130433
149semaphorin-plexin signaling pathway (GO:0071526)2.65660655
150tissue remodeling (GO:0048771)2.63973655
151extracellular matrix organization (GO:0030198)2.63739103
152branching involved in mammary gland duct morphogenesis (GO:0060444)2.63115310
153regulation of glucocorticoid metabolic process (GO:0031943)2.63103524
154lateral sprouting from an epithelium (GO:0060601)2.62639199
155extracellular structure organization (GO:0043062)2.62632488
156protein hydroxylation (GO:0018126)2.62117040
157actin filament depolymerization (GO:0030042)2.60267069
158establishment of spindle orientation (GO:0051294)2.59212023
159positive regulation of receptor recycling (GO:0001921)2.58995769
160stress fiber assembly (GO:0043149)2.58865235
161positive regulation of Rho protein signal transduction (GO:0035025)2.58662065
162positive regulation of interleukin-4 production (GO:0032753)2.58633113
163positive regulation of epithelial cell migration (GO:0010634)2.58144759
164regulation of collateral sprouting (GO:0048670)2.57636166
165positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.57167737
166ear development (GO:0043583)2.52427908
167positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.52081577
168creatine metabolic process (GO:0006600)2.51160270
169oocyte development (GO:0048599)2.49936033
170camera-type eye morphogenesis (GO:0048593)2.47269586
171positive regulation of humoral immune response (GO:0002922)2.44469635
172membrane protein ectodomain proteolysis (GO:0006509)2.42671563
173limb bud formation (GO:0060174)2.42169702
174histone H2B ubiquitination (GO:0033523)2.39700546
175negative regulation of homotypic cell-cell adhesion (GO:0034111)2.39545212
176negative regulation of meiotic cell cycle (GO:0051447)2.38954939
177cell-cell junction assembly (GO:0007043)2.37772643
178establishment of spindle localization (GO:0051293)2.34290926
179glycosylceramide metabolic process (GO:0006677)2.33774531
180microtubule severing (GO:0051013)2.31786797
181regulation of meiotic cell cycle (GO:0051445)2.31487703
182positive regulation of catenin import into nucleus (GO:0035413)2.30652674
183positive regulation of oligodendrocyte differentiation (GO:0048714)2.30335731
184regulation of steroid hormone secretion (GO:2000831)2.30295975
185long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.30268548
186* platelet-derived growth factor receptor signaling pathway (GO:0048008)2.29509231
187Rap protein signal transduction (GO:0032486)2.29402279

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human4.96743361
2RARG_19884340_ChIP-ChIP_MEFs_Mouse4.86538960
3EZH2_22144423_ChIP-Seq_EOC_Human3.65117971
4ELK3_25401928_ChIP-Seq_HUVEC_Human2.97490822
5* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.76988365
6TRIM28_21343339_ChIP-Seq_HEK293_Human2.71814223
7SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.52032757
8* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.51797012
9NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.44380529
10* CLOCK_20551151_ChIP-Seq_293T_Human2.43705581
11WT1_19549856_ChIP-ChIP_CCG9911_Human2.39260571
12* GATA2_21666600_ChIP-Seq_HMVEC_Human2.37077539
13GBX2_23144817_ChIP-Seq_PC3_Human2.36366212
14TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.36218443
15KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human2.28131035
16PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.26818779
17ZNF263_19887448_ChIP-Seq_K562_Human2.26727953
18CDX2_19796622_ChIP-Seq_MESCs_Mouse2.23076710
19TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.18844441
20HIF1A_21447827_ChIP-Seq_MCF-7_Human2.18819033
21SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.13930043
22SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.13046823
23SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.13046823
24SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.10533843
25EP300_21415370_ChIP-Seq_HL-1_Mouse2.10533144
26EZH2_18974828_ChIP-Seq_MESCs_Mouse2.06493640
27RNF2_18974828_ChIP-Seq_MESCs_Mouse2.06493640
28P300_27058665_Chip-Seq_ZR-75-30cells_Human2.00137773
29JARID2_20064375_ChIP-Seq_MESCs_Mouse1.98988634
30EED_16625203_ChIP-ChIP_MESCs_Mouse1.98033359
31* BRD4_25478319_ChIP-Seq_HGPS_Human1.97165538
32CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.96810847
33MTF2_20144788_ChIP-Seq_MESCs_Mouse1.90174330
34* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.88575513
35CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.87254240
36SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.86988575
37SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.83422036
38EZH2_27304074_Chip-Seq_ESCs_Mouse1.81124277
39UBF1/2_26484160_Chip-Seq_HMECs_Human1.78775036
40SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.77896330
41THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.77730056
42RACK7_27058665_Chip-Seq_MCF-7_Human1.77021073
43ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.76267265
44SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.74012429
45TP53_22127205_ChIP-Seq_IMR90_Human1.73047019
46* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.72965604
47* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.72767795
48NFIB_24661679_ChIP-Seq_LUNG_Mouse1.70964397
49UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.69358136
50RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.67830795
51EZH2_27294783_Chip-Seq_ESCs_Mouse1.64523131
52ZNF217_24962896_ChIP-Seq_MCF-7_Human1.63267492
53SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.63261815
54LXR_22292898_ChIP-Seq_THP-1_Human1.62986464
55EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.62396162
56OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.62384481
57RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.61818288
58AR_21572438_ChIP-Seq_LNCaP_Human1.61615701
59PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.61418668
60TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.60801836
61RNF2_27304074_Chip-Seq_ESCs_Mouse1.60274296
62ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.57608933
63* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.57557872
64PIAS1_25552417_ChIP-Seq_VCAP_Human1.55829700
65* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.54366111
66NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.53208668
67* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.51782341
68VDR_22108803_ChIP-Seq_LS180_Human1.51114537
69ATF3_27146783_Chip-Seq_COLON_Human1.50662925
70POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.47686075
71SUZ12_27294783_Chip-Seq_ESCs_Mouse1.46374619
72ESR2_21235772_ChIP-Seq_MCF-7_Human1.44838592
73SOX9_24532713_ChIP-Seq_HFSC_Mouse1.44627383
74AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.43768064
75SMAD3_21741376_ChIP-Seq_EPCs_Human1.40493676
76* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.40346077
77FOXO3_23340844_ChIP-Seq_DLD1_Human1.40154212
78ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.39720401
79CJUN_26792858_Chip-Seq_BT549_Human1.39257684
80* SMC1_22415368_ChIP-Seq_MEFs_Mouse1.38815182
81KDM2B_26808549_Chip-Seq_SUP-B15_Human1.38786833
82NRF2_20460467_ChIP-Seq_MEFs_Mouse1.35953371
83NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.35953371
84SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.35518881
85TBX20_22328084_ChIP-Seq_HEART_Mouse1.32941825
86TBX20_22080862_ChIP-Seq_HEART_Mouse1.32941825
87P63_26484246_Chip-Seq_KERATINOCYTES_Human1.31842675
88STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.31397506
89* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.30503445
90ESR1_21235772_ChIP-Seq_MCF-7_Human1.29154875
91CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.27973686
92GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.26204525
93ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.24064798
94PPAR_26484153_Chip-Seq_NCI-H1993_Human1.23554975
95BMI1_23680149_ChIP-Seq_NPCS_Mouse1.21744377
96SMC3_22415368_ChIP-Seq_MEFs_Mouse1.21721444
97SMAD_19615063_ChIP-ChIP_OVARY_Human1.20582701
98AHR_22903824_ChIP-Seq_MCF-7_Human1.20448524
99KDM2B_26808549_Chip-Seq_K562_Human1.20359323
100TP53_23651856_ChIP-Seq_MEFs_Mouse1.19209529
101CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.17822407
102NR3C1_23031785_ChIP-Seq_PC12_Mouse1.15822539
103TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.15614783
104CBX2_27304074_Chip-Seq_ESCs_Mouse1.15555526
105KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.15477751
106CDX2_20551321_ChIP-Seq_CACO-2_Human1.14087010
107SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.14075488
108NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.13958528
109STAT6_21828071_ChIP-Seq_BEAS2B_Human1.13794068
110TOP2B_26459242_ChIP-Seq_MCF-7_Human1.13257998
111ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.12619663
112ARNT_22903824_ChIP-Seq_MCF-7_Human1.12537585
113HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.12486143
114RXR_22108803_ChIP-Seq_LS180_Human1.12031632
115ER_23166858_ChIP-Seq_MCF-7_Human1.10496058
116* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.09409988
117TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08584992
118POU3F2_20337985_ChIP-ChIP_501MEL_Human1.07999774
119* STAT3_23295773_ChIP-Seq_U87_Human1.07493751
120EGR1_19374776_ChIP-ChIP_THP-1_Human1.07299568
121LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07186522
122FOXM1_26456572_ChIP-Seq_MCF-7_Human1.06787085
123* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.06395735
124SOX2_20726797_ChIP-Seq_SW620_Human1.05478032
125ESR1_20079471_ChIP-ChIP_T-47D_Human1.05413976
126TET1_21490601_ChIP-Seq_MESCs_Mouse1.04426797
127* SALL4_18804426_ChIP-ChIP_XEN_Mouse1.04266765
128RNF2_27304074_Chip-Seq_NSC_Mouse1.03981219
129ZFP57_27257070_Chip-Seq_ESCs_Mouse1.02862554
130NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.02420312
131NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.02316420
132SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.01909229
133SOX2_27498859_Chip-Seq_STOMACH_Mouse1.01671231
134CTBP2_25329375_ChIP-Seq_LNCAP_Human1.01094822
135ZFP281_27345836_Chip-Seq_ESCs_Mouse1.01034453
136* SA1_22415368_ChIP-Seq_MEFs_Mouse1.01005100
137TP53_20018659_ChIP-ChIP_R1E_Mouse1.00919822
138DROSHA_22980978_ChIP-Seq_HELA_Human1.00601157
139RING1B_27294783_Chip-Seq_NPCs_Mouse1.00404600
140FUS_26573619_Chip-Seq_HEK293_Human0.99317476
141* EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.99068690
142DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.99026486
143MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.98354893
144EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.98098018
145PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.98026095
146SMAD4_21799915_ChIP-Seq_A2780_Human0.97930489
147* KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.97726156
148ISL1_27105846_Chip-Seq_CPCs_Mouse0.97654360
149TP53_18474530_ChIP-ChIP_U2OS_Human0.97461678
150SMAD4_21741376_ChIP-Seq_EPCs_Human0.97372486
151ERG_21242973_ChIP-ChIP_JURKAT_Human0.97003751
152TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.95711739
153ZFP281_18757296_ChIP-ChIP_E14_Mouse0.95507002
154SMAD3_21741376_ChIP-Seq_HESCs_Human0.94770637
155MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.94474570
156* TP63_23658742_ChIP-Seq_EP156T_Human0.94120162
157P300_19829295_ChIP-Seq_ESCs_Human0.93957204
158SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.93018282
159PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.92177841
160TBL1_22424771_ChIP-Seq_293T_Human0.92062436
161TAF15_26573619_Chip-Seq_HEK293_Human0.92026515
162ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.91600288
163SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.91582964
164TP53_16413492_ChIP-PET_HCT116_Human0.91560945
165ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.91371536
166TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.91313754
167SOX2_21211035_ChIP-Seq_LN229_Gbm0.90952092
168CTNNB1_20460455_ChIP-Seq_HCT116_Human0.90486449
169TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.85237701
170FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.82979766
171EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.81829994
172DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.80775633

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005623_abnormal_meninges_morphology3.78974450
2MP0000920_abnormal_myelination3.77879719
3MP0003705_abnormal_hypodermis_morpholog3.65606857
4MP0003566_abnormal_cell_adhesion3.51345804
5MP0004272_abnormal_basement_membrane3.50028559
6MP0005257_abnormal_intraocular_pressure3.19342357
7MP0008438_abnormal_cutaneous_collagen3.18027403
8MP0003950_abnormal_plasma_membrane3.13411047
9MP0002877_abnormal_melanocyte_morpholog2.93833736
10MP0000751_myopathy2.88458174
11MP0003718_maternal_effect2.84754788
12MP0005503_abnormal_tendon_morphology2.82658487
13MP0009384_cardiac_valve_regurgitation2.77692840
14MP0005451_abnormal_body_composition2.75316400
15MP0003329_amyloid_beta_deposits2.58178370
16MP0001485_abnormal_pinna_reflex2.55655096
17MP0004885_abnormal_endolymph2.31878058
18MP0010368_abnormal_lymphatic_system2.30156237
19MP0000678_abnormal_parathyroid_gland2.23809468
20MP0003690_abnormal_glial_cell2.20067915
21MP0010678_abnormal_skin_adnexa2.19065106
22MP0000462_abnormal_digestive_system2.17387939
23MP0000383_abnormal_hair_follicle2.16214674
24MP0009780_abnormal_chondrocyte_physiolo2.11122344
25* MP0002295_abnormal_pulmonary_circulatio2.10956098
26MP0005023_abnormal_wound_healing2.10532173
27MP0003937_abnormal_limbs/digits/tail_de2.08570078
28MP0000537_abnormal_urethra_morphology2.02907853
29MP0001542_abnormal_bone_strength1.98026192
30MP0000778_abnormal_nervous_system1.90591773
31MP0003634_abnormal_glial_cell1.88018475
32MP0002896_abnormal_bone_mineralization1.81850059
33MP0005171_absent_coat_pigmentation1.81093453
34MP0000767_abnormal_smooth_muscle1.79897306
35MP0004270_analgesia1.77896949
36MP0002060_abnormal_skin_morphology1.67211723
37MP0003632_abnormal_nervous_system1.67140681
38MP0006054_spinal_hemorrhage1.67038808
39MP0005164_abnormal_response_to1.63113355
40MP0003942_abnormal_urinary_system1.56548055
41MP0003880_abnormal_central_pattern1.56272560
42MP0010352_gastrointestinal_tract_polyps1.56129407
43MP0004742_abnormal_vestibular_system1.55555406
44MP0005395_other_phenotype1.52920985
45MP0005275_abnormal_skin_tensile1.52873823
46MP0000534_abnormal_ureter_morphology1.52771886
47MP0000579_abnormal_nail_morphology1.52302081
48MP0001849_ear_inflammation1.51310006
49MP0001529_abnormal_vocalization1.50896425
50MP0009250_abnormal_appendicular_skeleto1.50313571
51MP0000858_altered_metastatic_potential1.49820193
52MP0004510_myositis1.48508105
53MP0001879_abnormal_lymphatic_vessel1.47471840
54MP0003448_altered_tumor_morphology1.45045205
55MP0001346_abnormal_lacrimal_gland1.38242961
56* MP0001905_abnormal_dopamine_level1.37935439
57MP0010030_abnormal_orbit_morphology1.35312686
58MP0009053_abnormal_anal_canal1.32365807
59MP0005390_skeleton_phenotype1.30958880
60MP0002653_abnormal_ependyma_morphology1.29347105
61MP0001661_extended_life_span1.29285476
62MP0001299_abnormal_eye_distance/1.23123568
63MP0009840_abnormal_foam_cell1.22149581
64MP0004185_abnormal_adipocyte_glucose1.21039234
65MP0000750_abnormal_muscle_regeneration1.20413952
66MP0005508_abnormal_skeleton_morphology1.18856384
67MP0001486_abnormal_startle_reflex1.17688117
68MP0003091_abnormal_cell_migration1.17629462
69MP0001963_abnormal_hearing_physiology1.16436844
70MP0004036_abnormal_muscle_relaxation1.16403589
71MP0001958_emphysema1.15712384
72MP0003136_yellow_coat_color1.14871210
73MP0000762_abnormal_tongue_morphology1.14200668
74MP0003699_abnormal_female_reproductive1.13044578
75* MP0005197_abnormal_uvea_morphology1.12515860
76MP0000026_abnormal_inner_ear1.12407580
77MP0004134_abnormal_chest_morphology1.11975484
78MP0008004_abnormal_stomach_pH1.11622770
79MP0003938_abnormal_ear_development1.11586567
80MP0003828_pulmonary_edema1.11407279
81MP0000604_amyloidosis1.10904004
82MP0000733_abnormal_muscle_development1.09955334
83MP0005408_hypopigmentation1.09635739
84MP0002249_abnormal_larynx_morphology1.09555715
85MP0004084_abnormal_cardiac_muscle1.09142857
86MP0003191_abnormal_cellular_cholesterol1.08393092
87* MP0002932_abnormal_joint_morphology1.06868047
88MP0003755_abnormal_palate_morphology1.03451192
89MP0005367_renal/urinary_system_phenotyp1.02215754
90MP0000516_abnormal_urinary_system1.02215754
91MP0000013_abnormal_adipose_tissue1.00876320
92MP0002108_abnormal_muscle_morphology0.99332956
93MP0000343_altered_response_to0.97680920
94MP0002168_other_aberrant_phenotype0.97431385
95MP0000955_abnormal_spinal_cord0.97215504
96MP0002229_neurodegeneration0.97112274
97MP0000163_abnormal_cartilage_morphology0.96442708
98MP0002272_abnormal_nervous_system0.96129321
99MP0003385_abnormal_body_wall0.96015968
100MP0001243_abnormal_dermal_layer0.95837787
101MP0000467_abnormal_esophagus_morphology0.95755625
102MP0002282_abnormal_trachea_morphology0.93469272
103* MP0002933_joint_inflammation0.93421113
104MP0002752_abnormal_somatic_nervous0.90483401
105MP0000747_muscle_weakness0.90357858
106MP0001533_abnormal_skeleton_physiology0.90357416
107MP0002233_abnormal_nose_morphology0.89847253
108MP0003453_abnormal_keratinocyte_physiol0.89452284
109MP0000230_abnormal_systemic_arterial0.89044892
110MP0003941_abnormal_skin_development0.88660159
111MP0000749_muscle_degeneration0.88470989
112MP0003315_abnormal_perineum_morphology0.88204985
113MP0008260_abnormal_autophagy0.87491490
114MP0002882_abnormal_neuron_morphology0.87153009
115MP0003045_fibrosis0.86885905
116MP0010234_abnormal_vibrissa_follicle0.85642583
117MP0000647_abnormal_sebaceous_gland0.84804517
118MP0001119_abnormal_female_reproductive0.84623399
119MP0000613_abnormal_salivary_gland0.83458870
120* MP0002925_abnormal_cardiovascular_devel0.82680884
121MP0004883_abnormal_blood_vessel0.82533215
122MP0002113_abnormal_skeleton_development0.82525029
123MP0002998_abnormal_bone_remodeling0.82058918
124MP0008775_abnormal_heart_ventricle0.81927624
125MP0005595_abnormal_vascular_smooth0.81881400
126MP0001348_abnormal_lacrimal_gland0.81521806
127MP0005193_abnormal_anterior_eye0.80792695
128MP0003861_abnormal_nervous_system0.80439702
129* MP0001915_intracranial_hemorrhage0.79642965
130* MP0002128_abnormal_blood_circulation0.79012563
131* MP0001614_abnormal_blood_vessel0.77906777
132MP0006138_congestive_heart_failure0.77827679
133MP0002332_abnormal_exercise_endurance0.77281499
134MP0003300_gastrointestinal_ulcer0.77133121
135MP0002116_abnormal_craniofacial_bone0.76938089
136MP0005058_abnormal_lysosome_morphology0.75821098
137MP0002734_abnormal_mechanical_nocicepti0.75240024
138MP0003279_aneurysm0.73754964
139MP0005501_abnormal_skin_physiology0.73598414
140MP0002064_seizures0.73421379
141MP0003436_decreased_susceptibility_to0.72423177
142MP0000465_gastrointestinal_hemorrhage0.72309901
143* MP0005195_abnormal_posterior_eye0.72241443
144MP0002152_abnormal_brain_morphology0.71256620
145MP0001929_abnormal_gametogenesis0.71226575
146MP0000249_abnormal_blood_vessel0.71004696
147MP0004858_abnormal_nervous_system0.70592708
148MP0000627_abnormal_mammary_gland0.70448346
149MP0000566_synostosis0.70008962
150MP0003935_abnormal_craniofacial_develop0.69737675
151MP0000759_abnormal_skeletal_muscle0.69190664
152MP0000428_abnormal_craniofacial_morphol0.68777902
153MP0002102_abnormal_ear_morphology0.67966652
154MP0002115_abnormal_skeleton_extremities0.67708091
155MP0003795_abnormal_bone_structure0.67700990
156MP0000653_abnormal_sex_gland0.67530569
157MP0003631_nervous_system_phenotype0.67466264
158MP0002089_abnormal_postnatal_growth/wei0.66574138
159MP0000049_abnormal_middle_ear0.66504309
160MP0002796_impaired_skin_barrier0.65890865
161MP0010771_integument_phenotype0.65879369
162MP0005165_increased_susceptibility_to0.65317431

Predicted human phenotypes

RankGene SetZ-score
1Focal segmental glomerulosclerosis (HP:0000097)5.28906483
2Neurofibrillary tangles (HP:0002185)4.72872136
3Degeneration of the lateral corticospinal tracts (HP:0002314)4.65076990
4Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)4.65076990
5Mesangial abnormality (HP:0001966)4.49591930
6Increased circulating renin level (HP:0000848)4.22766391
7Follicular hyperkeratosis (HP:0007502)4.19341776
8Atrophic scars (HP:0001075)4.18396265
9Glomerulosclerosis (HP:0000096)4.15413739
10Aortic aneurysm (HP:0004942)3.95691755
11Spinal rigidity (HP:0003306)3.93416159
12Type 1 muscle fiber predominance (HP:0003803)3.85707557
13Parakeratosis (HP:0001036)3.76036478
14Sensory axonal neuropathy (HP:0003390)3.69142096
15Fragile skin (HP:0001030)3.59535194
16Cervical subluxation (HP:0003308)3.42640642
17Cerebral inclusion bodies (HP:0100314)3.35768128
18Abnormal albumin level (HP:0012116)3.35175173
19Hypoalbuminemia (HP:0003073)3.35175173
20Bladder diverticulum (HP:0000015)3.32529300
21Hypomagnesemia (HP:0002917)3.30693314
22Coronal craniosynostosis (HP:0004440)3.24463772
23Aplasia involving bones of the extremities (HP:0009825)3.23500994
24Aplasia involving bones of the upper limbs (HP:0009823)3.23500994
25Aplasia of the phalanges of the hand (HP:0009802)3.23500994
26Abnormality of the corticospinal tract (HP:0002492)3.21250371
27Mildly elevated creatine phosphokinase (HP:0008180)3.19846174
28Slender build (HP:0001533)3.16435309
29Short nail (HP:0001799)3.13611944
30Arterial tortuosity (HP:0005116)3.12723237
31Achilles tendon contracture (HP:0001771)3.07600536
32Soft skin (HP:0000977)3.05830849
33Vertebral compression fractures (HP:0002953)3.03819409
34Hypokalemic alkalosis (HP:0001949)3.03264575
35Wormian bones (HP:0002645)3.00624858
36Cerebral aneurysm (HP:0004944)2.97052417
37Stage 5 chronic kidney disease (HP:0003774)2.94119557
38Vascular tortuosity (HP:0004948)2.86695539
39Blue sclerae (HP:0000592)2.83776469
40Abnormality of the middle phalanges of the toes (HP:0010183)2.82378098
41Premature rupture of membranes (HP:0001788)2.80637811
42Spondylolisthesis (HP:0003302)2.79199857
43Increased variability in muscle fiber diameter (HP:0003557)2.78933887
44Increased connective tissue (HP:0009025)2.78257622
45Humeroradial synostosis (HP:0003041)2.78133478
46Synostosis involving the elbow (HP:0003938)2.78133478
47Genu recurvatum (HP:0002816)2.78107292
48Male infertility (HP:0003251)2.75461437
49Elbow flexion contracture (HP:0002987)2.75386088
50Hypoventilation (HP:0002791)2.68226419
51Mitral valve prolapse (HP:0001634)2.67901422
52Abnormality of the Achilles tendon (HP:0005109)2.66194497
53Anomalous pulmonary venous return (HP:0010772)2.58755825
54Dilatation of the ascending aorta (HP:0005111)2.57694895
55Distal upper limb amyotrophy (HP:0007149)2.57553668
56Upper limb amyotrophy (HP:0009129)2.57553668
57Broad face (HP:0000283)2.55352217
58Shallow orbits (HP:0000586)2.54097693
59Abnormality of the phalanges of the 2nd finger (HP:0009541)2.53360045
60Termporal pattern (HP:0011008)2.53141382
61Insidious onset (HP:0003587)2.53141382
62Overgrowth (HP:0001548)2.51489912
63Short hallux (HP:0010109)2.51191367
64Broad metatarsal (HP:0001783)2.50231184
65Joint laxity (HP:0001388)2.50122384
66Delayed epiphyseal ossification (HP:0002663)2.49117384
67Hypoplasia of the iris (HP:0007676)2.47123006
68Adrenal hypoplasia (HP:0000835)2.46539559
69Onion bulb formation (HP:0003383)2.45707859
70Peripheral hypomyelination (HP:0007182)2.44457507
71Ulnar bowing (HP:0003031)2.44073940
72Distal lower limb amyotrophy (HP:0008944)2.43659062
73Abnormality of magnesium homeostasis (HP:0004921)2.42907949
74Abnormality of skeletal muscle fiber size (HP:0012084)2.40771242
75Cerebral hypomyelination (HP:0006808)2.39610967
76Tetany (HP:0001281)2.38730440
77Aneurysm (HP:0002617)2.36807372
78Premature skin wrinkling (HP:0100678)2.36278820
79Generalized amyotrophy (HP:0003700)2.36187901
80Nonprogressive disorder (HP:0003680)2.35268487
81Increased serum pyruvate (HP:0003542)2.34411316
82Abnormality of glycolysis (HP:0004366)2.34411316
83Neonatal short-limb short stature (HP:0008921)2.32329583
84Morphological abnormality of the inner ear (HP:0011390)2.31978943
85Osteolytic defects of the hand bones (HP:0009699)2.31157920
86Osteolytic defects of the phalanges of the hand (HP:0009771)2.31157920
87Abnormality of the pulmonary veins (HP:0011718)2.27053479
88Long toe (HP:0010511)2.26275025
89Chin dimple (HP:0010751)2.25721465
90Nephrotic syndrome (HP:0000100)2.22352684
91Abnormality of the acetabulum (HP:0003170)2.21443964
92Aortic dissection (HP:0002647)2.19436171
93Difficulty climbing stairs (HP:0003551)2.18117982
94Aplasia/Hypoplasia of the hallux (HP:0008362)2.16206519
95Akinesia (HP:0002304)2.14473321
96Peritonitis (HP:0002586)2.13736533
97Supranuclear gaze palsy (HP:0000605)2.13269865
98Abnormality of the umbilical cord (HP:0010881)2.12701562
99Abnormal drinking behavior (HP:0030082)2.11337855
100Polydipsia (HP:0001959)2.11337855
101Bronchomalacia (HP:0002780)2.10172188
102Abnormality of the distal phalanges of the toes (HP:0010182)2.09713385
103Tubular atrophy (HP:0000092)2.09456841
104Distal lower limb muscle weakness (HP:0009053)2.08885289
105Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.08380108
106Obstructive sleep apnea (HP:0002870)2.07787232
107Spastic gait (HP:0002064)2.07671477
108Hydroureter (HP:0000072)2.07480812
109Metabolic alkalosis (HP:0200114)2.06686879
110Ankyloglossia (HP:0010296)2.06618267
111Coxa vara (HP:0002812)2.05985314
112Cardiovascular calcification (HP:0011915)2.05592096
113Protruding ear (HP:0000411)2.04518912
114Abnormality of the fetal cardiovascular system (HP:0010948)2.04414078
115Abnormal umbilical cord blood vessels (HP:0011403)2.04414078
116Single umbilical artery (HP:0001195)2.04414078
117Natal tooth (HP:0000695)2.03929921
118Hyperextensible skin (HP:0000974)2.03232810
119Corneal erosion (HP:0200020)2.03182933
120Cerebral hemorrhage (HP:0001342)2.02732523
121Hypoplastic pelvis (HP:0008839)2.02459065
122Atelectasis (HP:0100750)2.02013354
123Metaphyseal dysplasia (HP:0100255)2.01821241
124Reduced subcutaneous adipose tissue (HP:0003758)2.01658805
125Disproportionate tall stature (HP:0001519)2.01378432
126Biconcave vertebral bodies (HP:0004586)2.00761269
127Aortic regurgitation (HP:0001659)2.00746183
128Hand muscle atrophy (HP:0009130)2.00393325
129Abnormality of oral frenula (HP:0000190)1.99370548
130Retinal dysplasia (HP:0007973)1.98265098
131Muscle fiber splitting (HP:0003555)1.97407052
132Mitral regurgitation (HP:0001653)1.96952376
133Ankle contracture (HP:0006466)1.96394223
134Wide anterior fontanel (HP:0000260)1.96200698
135Joint stiffness (HP:0001387)1.96106054
136Small epiphyses (HP:0010585)1.94906204
137Neonatal death (HP:0003811)1.94356674
138Abnormality of dentin (HP:0010299)1.92869527
139Stenosis of the external auditory canal (HP:0000402)1.92129829
140Bowing of the arm (HP:0006488)1.91751065
141Bowed forearm bones (HP:0003956)1.91751065
142Bell-shaped thorax (HP:0001591)1.90933510
143Alacrima (HP:0000522)1.90883342
144Hyperacusis (HP:0010780)1.90525386
145Protrusio acetabuli (HP:0003179)1.90312833
146Hyperphosphatemia (HP:0002905)1.89702341
147Aplasia/Hypoplasia involving the musculature (HP:0001460)1.89480171
148Aplasia of the musculature (HP:0100854)1.89163603
149Osteopenia (HP:0000938)1.88338738
150Thickened helices (HP:0000391)1.87902628
151Pterygium (HP:0001059)1.87409402
152Bifid scrotum (HP:0000048)1.86201444
153Spinal cord compression (HP:0002176)1.84919215
154Bowel diverticulosis (HP:0005222)1.84357867
155Fragile nails (HP:0001808)1.84125216
156Esophageal atresia (HP:0002032)1.84071582
157Infertility (HP:0000789)1.83917365
158Autoamputation (HP:0001218)1.83785467
159Abnormality of the 2nd finger (HP:0004100)1.83683501
160Scapular winging (HP:0003691)1.83636023
161Limb-girdle muscle weakness (HP:0003325)1.82811740
162Infantile muscular hypotonia (HP:0008947)1.82380493
163Intention tremor (HP:0002080)1.82334378
164Lower limb amyotrophy (HP:0007210)1.80095962
165Abnormal delivery (HP:0001787)1.79946485
166Abnormal auditory evoked potentials (HP:0006958)1.76620152
167Abnormality of cochlea (HP:0000375)1.76404744
168Flat acetabular roof (HP:0003180)1.73540012
169Buphthalmos (HP:0000557)1.73471532
170Menorrhagia (HP:0000132)1.73217332
171Abnormality of carpal bone ossification (HP:0006257)1.73103522
172Ectopia lentis (HP:0001083)1.72976747
173Abnormal ossification of hand bones (HP:0005921)1.72349206
174Trismus (HP:0000211)1.71585908
175J-shaped sella turcica (HP:0002680)1.71487388
176Hypoplastic left heart (HP:0004383)1.69766193
177Polyuria (HP:0000103)1.68887222
178Vascular calcification (HP:0004934)1.68852829
179Abnormality of the proximal phalanges of the hand (HP:0009834)1.68457270
180Dysmetria (HP:0001310)1.68150861
181Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)1.68011580
182Radial bowing (HP:0002986)1.66814316
183Stridor (HP:0010307)1.66036927
184Glucose intolerance (HP:0000833)1.65788859
185Spastic paraparesis (HP:0002313)1.65277445
186Cupped ear (HP:0000378)1.65118219
187Premature ovarian failure (HP:0008209)1.64635895
188Megalencephaly (HP:0001355)1.62654146
189Neonatal respiratory distress (HP:0002643)1.61777865
190Epiphyseal dysplasia (HP:0002656)1.61745421

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK396.50653970
2OXSR15.02701350
3WNK44.69857845
4MOS3.71391125
5BMPR23.56237878
6EPHB13.37494234
7PDGFRA3.27669302
8MST1R3.24252498
9MYLK2.72827102
10LMTK22.44252966
11ERN12.42334774
12RIPK12.14158977
13MAP3K32.04492015
14IRAK32.01760784
15FLT32.00014261
16TTN1.99874431
17TESK11.96658924
18EPHB21.91196552
19STK101.90416389
20BCR1.89958502
21SIK11.86195001
22TTK1.76279743
23MET1.73956389
24TRIB31.67137366
25TAOK31.67100766
26CSNK1A1L1.64333112
27CSNK1G31.58582346
28CSNK1G11.54121787
29NTRK11.53299271
30ROCK21.52840456
31MAPKAPK51.51639757
32PAK61.51219058
33CDK191.46826860
34TIE11.40459531
35WNK11.37470354
36ICK1.34956457
37ERBB41.28422779
38FGFR21.28212293
39TNIK1.26724433
40NEK61.23033428
41MST41.22328396
42CSNK1G21.21619515
43GRK51.19647295
44STK381.18277615
45MAP3K131.17523693
46PKN11.14134344
47CDK81.13660288
48PBK1.13466321
49LATS11.13289085
50MELK1.10837955
51TYRO31.08691086
52LIMK11.03355188
53PRKG21.02366682
54MAP3K61.01691926
55PAK30.97148427
56PTK60.96386301
57NME20.96107517
58CAMK2B0.95145876
59NEK90.94812561
60DDR20.93165137
61ARAF0.92916809
62PKN20.90480863
63EPHA30.90329625
64PIM20.89964806
65BRAF0.87686744
66ZAP700.87163539
67ROCK10.86901900
68KSR20.86202153
69FGR0.86200720
70GRK70.83480985
71CDC42BPA0.83317431
72TESK20.81288549
73PIK3CG0.79530891
74DYRK20.78672092
75LRRK20.78482810
76MAP3K90.76154398
77PRPF4B0.74076444
78RPS6KA20.73625298
79PNCK0.72414886
80ILK0.72352967
81TRPM70.71823498
82CLK10.71012377
83LATS20.65988105
84UHMK10.63969943
85ABL20.63953743
86PLK20.62129204
87MUSK0.59636125
88CDK140.59362674
89RET0.57361113
90SMG10.57298528
91MARK20.57189163
92SGK2230.56597309
93SGK4940.56597309
94PRKCQ0.56347771
95TAOK20.55264887
96CDK150.55239096
97MTOR0.54784673
98CAMK2A0.53368323
99MAP2K30.52551148
100EPHA40.52067341
101CAMK2D0.51494940
102PDGFRB0.51149393
103PRKD10.50260654
104CDK180.49543067
105BMX0.49494712
106PRKCE0.49117623
107DMPK0.48911756
108FER0.48121247
109CDK11A0.46110212
110PTK20.44681037
111GRK10.43360529
112PAK40.43022662
113EPHA20.42763360
114PAK20.42670971
115DAPK30.42128957
116PRKD20.40352687
117MAP3K80.40022704
118CDK50.39965556
119MAPK150.39774790
120PTK2B0.39391547
121FGFR40.39354525
122STK30.38999160
123PDPK10.38759762
124CAMK2G0.38604706
125MAPK130.38343256
126PIK3CA0.37341441
127MAP3K120.37051327
128CSNK1D0.36690471
129PAK10.36427877
130MAP3K70.35979527
131GSK3A0.35536598
132SRC0.35253332
133TGFBR20.35228746
134JAK10.34755693
135SCYL20.33970460
136NLK0.33258803
137FYN0.32983190
138PHKG20.32653497
139PHKG10.32653497
140AKT30.31992770
141ADRBK10.31820637
142PRKD30.31713836
143BMPR1B0.30523342
144ABL10.29842865
145PLK40.29269828
146CHUK0.25068669
147MAPKAPK20.23097729
148TGFBR10.22391152
149STK38L0.21977513
150MAP2K10.20545448
151IGF1R0.19849490
152CDK90.19753528
153MAP3K10.19692339
154KSR10.19599877
155TBK10.17124410

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009004.51404628
2Steroid biosynthesis_Homo sapiens_hsa001003.73476732
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.23611125
4Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.97078338
5Ether lipid metabolism_Homo sapiens_hsa005652.92106658
6Fatty acid elongation_Homo sapiens_hsa000622.86636460
7ECM-receptor interaction_Homo sapiens_hsa045122.84691343
8Ovarian steroidogenesis_Homo sapiens_hsa049132.75821513
9Axon guidance_Homo sapiens_hsa043602.64152715
10Glycosaminoglycan degradation_Homo sapiens_hsa005312.59543712
11Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.81921481
12Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.72953756
13Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.71680299
14Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.62728259
15Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.61914909
16alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.61013580
17Focal adhesion_Homo sapiens_hsa045101.60810008
18Linoleic acid metabolism_Homo sapiens_hsa005911.57304865
19Renal cell carcinoma_Homo sapiens_hsa052111.56648526
20Sphingolipid metabolism_Homo sapiens_hsa006001.55279347
21Tight junction_Homo sapiens_hsa045301.54720996
22Chronic myeloid leukemia_Homo sapiens_hsa052201.51930054
23Dorso-ventral axis formation_Homo sapiens_hsa043201.46849618
24Central carbon metabolism in cancer_Homo sapiens_hsa052301.40603231
25Other glycan degradation_Homo sapiens_hsa005111.37073686
26N-Glycan biosynthesis_Homo sapiens_hsa005101.36832164
27Hippo signaling pathway_Homo sapiens_hsa043901.32249281
28Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.31127092
29Thyroid cancer_Homo sapiens_hsa052161.30663269
30Hedgehog signaling pathway_Homo sapiens_hsa043401.24267572
31Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.23456806
32* Complement and coagulation cascades_Homo sapiens_hsa046101.23206524
33Regulation of actin cytoskeleton_Homo sapiens_hsa048101.21859547
34TGF-beta signaling pathway_Homo sapiens_hsa043501.18486219
35Amoebiasis_Homo sapiens_hsa051461.18245869
36Prion diseases_Homo sapiens_hsa050201.18043326
37Ras signaling pathway_Homo sapiens_hsa040141.17721171
38Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.16634261
39Galactose metabolism_Homo sapiens_hsa000521.13406810
40Protein digestion and absorption_Homo sapiens_hsa049741.13349745
41Phospholipase D signaling pathway_Homo sapiens_hsa040721.08552007
42Long-term depression_Homo sapiens_hsa047301.08005836
43Sulfur metabolism_Homo sapiens_hsa009201.07616795
44Pancreatic cancer_Homo sapiens_hsa052121.06474071
45Small cell lung cancer_Homo sapiens_hsa052221.05233938
46Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.01434487
47Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.01231484
48Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.01109783
49Vitamin B6 metabolism_Homo sapiens_hsa007500.98383870
50MicroRNAs in cancer_Homo sapiens_hsa052060.98367004
51Glioma_Homo sapiens_hsa052140.93906942
52Serotonergic synapse_Homo sapiens_hsa047260.93595368
53Proteoglycans in cancer_Homo sapiens_hsa052050.93009168
54Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.92658634
55Thyroid hormone signaling pathway_Homo sapiens_hsa049190.92359698
56PI3K-Akt signaling pathway_Homo sapiens_hsa041510.90950845
57Circadian rhythm_Homo sapiens_hsa047100.89343490
58Glutamatergic synapse_Homo sapiens_hsa047240.88564865
59TNF signaling pathway_Homo sapiens_hsa046680.88105106
60Dilated cardiomyopathy_Homo sapiens_hsa054140.87682157
61Endocytosis_Homo sapiens_hsa041440.86863118
62Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.86433277
63Vascular smooth muscle contraction_Homo sapiens_hsa042700.86428066
64Butanoate metabolism_Homo sapiens_hsa006500.85647506
65Sphingolipid signaling pathway_Homo sapiens_hsa040710.82183525
66Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.81304267
67Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.81008278
68Basal cell carcinoma_Homo sapiens_hsa052170.80724676
69Vibrio cholerae infection_Homo sapiens_hsa051100.80268520
70Lysosome_Homo sapiens_hsa041420.79687542
71Choline metabolism in cancer_Homo sapiens_hsa052310.78505118
72Adherens junction_Homo sapiens_hsa045200.78503558
73Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.77377625
74Rheumatoid arthritis_Homo sapiens_hsa053230.76562792
75Arginine and proline metabolism_Homo sapiens_hsa003300.75900945
76Wnt signaling pathway_Homo sapiens_hsa043100.75850316
77Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.75676449
78AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.74930360
79Rap1 signaling pathway_Homo sapiens_hsa040150.73619019
80Gap junction_Homo sapiens_hsa045400.73395855
81Salmonella infection_Homo sapiens_hsa051320.72637459
82ErbB signaling pathway_Homo sapiens_hsa040120.72247854
83Malaria_Homo sapiens_hsa051440.71972144
84Mineral absorption_Homo sapiens_hsa049780.70278870
85Neurotrophin signaling pathway_Homo sapiens_hsa047220.70178966
86Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.70070703
87Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.68938807
88Protein export_Homo sapiens_hsa030600.67332131
89Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.64888948
90Leukocyte transendothelial migration_Homo sapiens_hsa046700.64272448
91Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.64216325
92Endometrial cancer_Homo sapiens_hsa052130.64059336
93Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.63773080
94GnRH signaling pathway_Homo sapiens_hsa049120.63676887
95Arachidonic acid metabolism_Homo sapiens_hsa005900.62442489
96Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.61407785
97Apoptosis_Homo sapiens_hsa042100.61103624
98Pathways in cancer_Homo sapiens_hsa052000.60638443
99Fructose and mannose metabolism_Homo sapiens_hsa000510.60311708
100Renin-angiotensin system_Homo sapiens_hsa046140.59988626
101Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.59949089
102Notch signaling pathway_Homo sapiens_hsa043300.59775283
103Gastric acid secretion_Homo sapiens_hsa049710.59332245
104Oocyte meiosis_Homo sapiens_hsa041140.58136578
105Pentose phosphate pathway_Homo sapiens_hsa000300.58005318
106p53 signaling pathway_Homo sapiens_hsa041150.57934640
107Collecting duct acid secretion_Homo sapiens_hsa049660.57477644
108Toxoplasmosis_Homo sapiens_hsa051450.57292412
109Cyanoamino acid metabolism_Homo sapiens_hsa004600.55802728
110Basal transcription factors_Homo sapiens_hsa030220.55593723
111Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.54300654
112Thyroid hormone synthesis_Homo sapiens_hsa049180.54073915
113GABAergic synapse_Homo sapiens_hsa047270.53251177
114VEGF signaling pathway_Homo sapiens_hsa043700.52517642
115Prolactin signaling pathway_Homo sapiens_hsa049170.51487642
116Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.50426568
117Pertussis_Homo sapiens_hsa051330.50371727
118Platelet activation_Homo sapiens_hsa046110.49990581
119Phagosome_Homo sapiens_hsa041450.48505572
120Prostate cancer_Homo sapiens_hsa052150.47438630
121MAPK signaling pathway_Homo sapiens_hsa040100.47338660
122Fatty acid metabolism_Homo sapiens_hsa012120.46679571
123Acute myeloid leukemia_Homo sapiens_hsa052210.46483284
124cGMP-PKG signaling pathway_Homo sapiens_hsa040220.42924898
125Non-small cell lung cancer_Homo sapiens_hsa052230.42461381
126Salivary secretion_Homo sapiens_hsa049700.42391828
127Glycerophospholipid metabolism_Homo sapiens_hsa005640.42317728
128Bladder cancer_Homo sapiens_hsa052190.42213736
129Cholinergic synapse_Homo sapiens_hsa047250.41788777
130Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.41763473
131cAMP signaling pathway_Homo sapiens_hsa040240.40909866
132Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.40230888
133HTLV-I infection_Homo sapiens_hsa051660.38857460
134Hepatitis C_Homo sapiens_hsa051600.38831567
135Oxytocin signaling pathway_Homo sapiens_hsa049210.38825652
136Inositol phosphate metabolism_Homo sapiens_hsa005620.38704512
137Melanogenesis_Homo sapiens_hsa049160.38684290
138Insulin signaling pathway_Homo sapiens_hsa049100.38153072
139Hepatitis B_Homo sapiens_hsa051610.37722524
140Glutathione metabolism_Homo sapiens_hsa004800.37360044
141Shigellosis_Homo sapiens_hsa051310.37158266
142Estrogen signaling pathway_Homo sapiens_hsa049150.36103294
143HIF-1 signaling pathway_Homo sapiens_hsa040660.35162598
144Histidine metabolism_Homo sapiens_hsa003400.34756256
145Melanoma_Homo sapiens_hsa052180.34022058
146Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.32738797

Most similar genes based on co-expression Upload to Enrichr

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