PLAU

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a secreted serine protease that converts plasminogen to plasmin. The encoded preproprotein is proteolytically processed to generate A and B polypeptide chains. These chains associate via a single disulfide bond to form the catalytically inactive high molecular weight urokinase-type plasminogen activator (HMW-uPA). HMW-uPA can be further processed into the catalytically active low molecular weight urokinase-type plasminogen activator (LMW-uPA). This low molecular weight form does not bind to the urokinase-type plasminogen activator receptor. Mutations in this gene may be associated with Quebec platelet disorder and late-onset Alzheimer's disease. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1hemidesmosome assembly (GO:0031581)6.52802213
2mesodermal cell differentiation (GO:0048333)6.40110774
3modulation by symbiont of host defense response (GO:0052031)6.38942912
4modulation by organism of immune response of other organism involved in symbiotic interaction (GO:006.38942912
5modulation by organism of defense response of other organism involved in symbiotic interaction (GO:06.38942912
6positive regulation by organism of defense response of other organism involved in symbiotic interact6.38942912
7modulation by symbiont of host immune response (GO:0052553)6.38942912
8positive regulation by symbiont of host defense response (GO:0052509)6.38942912
9skin morphogenesis (GO:0043589)6.37317691
10metanephric nephron epithelium development (GO:0072243)5.30979099
11protein localization to endosome (GO:0036010)5.04274880
12protein maturation by protein folding (GO:0022417)4.98513178
13COPI coating of Golgi vesicle (GO:0048205)4.90265667
14Golgi transport vesicle coating (GO:0048200)4.90265667
15metanephric epithelium development (GO:0072207)4.89970068
16metanephric tubule development (GO:0072170)4.83128400
17metanephric nephron tubule development (GO:0072234)4.83128400
18cell adhesion mediated by integrin (GO:0033627)4.62417860
19hypotonic response (GO:0006971)4.61402258
20maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.53650150
21macrophage activation involved in immune response (GO:0002281)4.41069517
22protein retention in ER lumen (GO:0006621)4.33126502
23endodermal cell differentiation (GO:0035987)4.30866296
24urate metabolic process (GO:0046415)4.27740603
25negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)4.26194895
26toxin transport (GO:1901998)4.25920308
27microglial cell activation (GO:0001774)4.25548391
28barbed-end actin filament capping (GO:0051016)4.25466287
29membrane raft organization (GO:0031579)4.25318959
30lung vasculature development (GO:0060426)4.13861609
31regulation of metalloenzyme activity (GO:0048552)4.09850607
32response to peptidoglycan (GO:0032494)4.07089745
33response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.04816774
34response to host immune response (GO:0052572)4.04816774
35excretion (GO:0007588)3.99200213
36dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.91814598
37regulation of interferon-beta biosynthetic process (GO:0045357)3.85920908
38organic cation transport (GO:0015695)3.79113555
39nephron epithelium development (GO:0072009)3.77204477
40cellular copper ion homeostasis (GO:0006878)3.73013118
41wound healing, spreading of epidermal cells (GO:0035313)3.71380689
42aminoglycoside antibiotic metabolic process (GO:0030647)3.63956811
43cell-substrate junction assembly (GO:0007044)3.63226437
44* muscle cell migration (GO:0014812)3.63000294
45response to host (GO:0075136)3.60756334
46response to host defenses (GO:0052200)3.60756334
47response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.60756334
48drug transport (GO:0015893)3.60432664
49drug transmembrane transport (GO:0006855)3.57548109
50extracellular fibril organization (GO:0043206)3.52714680
51type B pancreatic cell proliferation (GO:0044342)3.52255928
52nephron tubule development (GO:0072080)3.46626244
53regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.38865902
54endothelial cell chemotaxis (GO:0035767)3.33262207
55substrate-dependent cell migration (GO:0006929)3.32457755
56protein hydroxylation (GO:0018126)3.28937039
57cellular response to vitamin (GO:0071295)3.24945059
58negative regulation of chondrocyte differentiation (GO:0032331)3.23382298
59mammary gland epithelial cell proliferation (GO:0033598)3.23152855
60cellular response to vitamin D (GO:0071305)3.22943661
61actin filament depolymerization (GO:0030042)3.22037152
62renal absorption (GO:0070293)3.21793806
63chondrocyte proliferation (GO:0035988)3.18963886
64endoplasmic reticulum calcium ion homeostasis (GO:0032469)3.17881782
65fibril organization (GO:0097435)3.17596988
66antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.15210587
67negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)3.14458296
68regulation of mononuclear cell migration (GO:0071675)3.13081803
69positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.10039188
70renal tubule development (GO:0061326)3.07649956
71response to gravity (GO:0009629)3.07636742
72apoptotic cell clearance (GO:0043277)3.07143124
73polyol transport (GO:0015791)3.05766984
74I-kappaB phosphorylation (GO:0007252)3.04959044
75positive regulation of actin filament depolymerization (GO:0030836)3.04788783
76regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.03010441
77neutrophil activation involved in immune response (GO:0002283)3.02604242
78regulation of glomerular filtration (GO:0003093)3.02420852
79vitamin D metabolic process (GO:0042359)3.02375582
80desmosome organization (GO:0002934)3.02361741
81positive regulation of heat generation (GO:0031652)2.99052507
82positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.97876172
83positive regulation of bone resorption (GO:0045780)2.95482329
84positive regulation of bone remodeling (GO:0046852)2.95482329
85glycoside metabolic process (GO:0016137)2.94863670
86detection of molecule of bacterial origin (GO:0032490)2.94741048
87positive regulation of interferon-alpha production (GO:0032727)2.93819886
88nuclear envelope reassembly (GO:0031468)2.92217771
89mitotic nuclear envelope reassembly (GO:0007084)2.92217771
90positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.91862505
91regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.91765005
92membrane protein ectodomain proteolysis (GO:0006509)2.90380023
93response to thyroid hormone (GO:0097066)2.88208491
94negative regulation of anoikis (GO:2000811)2.87135629
95macrophage activation (GO:0042116)2.84644983
96regulation of interferon-alpha production (GO:0032647)2.84495722
97positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.83467201
98positive regulation of interleukin-8 secretion (GO:2000484)2.80073201
99stress fiber assembly (GO:0043149)2.79408204
100positive regulation of macrophage cytokine production (GO:0060907)2.78920601
101pinocytosis (GO:0006907)2.78659801
102negative regulation of stem cell proliferation (GO:2000647)2.77873641
103respiratory tube development (GO:0030323)2.77265316
104positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.75053653
105positive regulation of astrocyte differentiation (GO:0048711)2.73680723
106adhesion of symbiont to host cell (GO:0044650)2.72943998
107virion attachment to host cell (GO:0019062)2.72943998
108epithelial cell-cell adhesion (GO:0090136)2.71759501
109oligosaccharide catabolic process (GO:0009313)2.71605254
110glomerular basement membrane development (GO:0032836)2.71434030
111positive regulation of toll-like receptor signaling pathway (GO:0034123)2.70947058
112regulation of collagen metabolic process (GO:0010712)2.70139840
113leukocyte migration involved in inflammatory response (GO:0002523)2.69392139
114positive regulation of osteoblast proliferation (GO:0033690)2.68362830
115endothelial tube morphogenesis (GO:0061154)2.68293061
116morphogenesis of an endothelium (GO:0003159)2.68293061
117collagen metabolic process (GO:0032963)2.67906772
118wound healing, spreading of cells (GO:0044319)2.66665570
119cortical actin cytoskeleton organization (GO:0030866)2.66617953
120response to vitamin D (GO:0033280)2.66452443
121ganglion development (GO:0061548)2.66386321
122copper ion homeostasis (GO:0055070)2.65467088
123adhesion of symbiont to host (GO:0044406)2.65329606
124establishment of viral latency (GO:0019043)2.64225226
125phosphate ion transport (GO:0006817)2.63470274
126keratan sulfate catabolic process (GO:0042340)2.63152650
127extracellular matrix disassembly (GO:0022617)2.62656565
128positive regulation of pseudopodium assembly (GO:0031274)2.61619826
129monocyte chemotaxis (GO:0002548)2.61463177
130endothelium development (GO:0003158)2.60808588
131mesenchymal-epithelial cell signaling (GO:0060638)2.60657358
132retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.59683748
133regulation of epidermal growth factor-activated receptor activity (GO:0007176)2.58893008
134collagen catabolic process (GO:0030574)2.58726393
135keratinocyte proliferation (GO:0043616)2.58572701
136endothelial cell morphogenesis (GO:0001886)2.58018179
137negative regulation of interleukin-17 production (GO:0032700)2.57870856
138response to muramyl dipeptide (GO:0032495)2.57482759
139response to mercury ion (GO:0046689)2.57378689
140positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.56530039
141regulation of membrane protein ectodomain proteolysis (GO:0051043)2.56377911
142branching involved in mammary gland duct morphogenesis (GO:0060444)2.56003014
143cellular response to hepatocyte growth factor stimulus (GO:0035729)2.55095711
144response to hepatocyte growth factor (GO:0035728)2.55095711
145import into cell (GO:0098657)2.55059100
146positive regulation of Rho protein signal transduction (GO:0035025)2.54254891
147positive regulation of smooth muscle cell migration (GO:0014911)2.52317261
148endocardial cushion development (GO:0003197)2.51627389
149peptidyl-proline hydroxylation (GO:0019511)2.51486121
150positive regulation of endothelial cell apoptotic process (GO:2000353)2.50936209
151positive regulation of p38MAPK cascade (GO:1900745)2.50583044
152negative regulation of smooth muscle cell migration (GO:0014912)2.49175346
153modulation by symbiont of host cellular process (GO:0044068)2.48792230
154negative regulation of axon extension involved in axon guidance (GO:0048843)2.48720585
155regulation of integrin-mediated signaling pathway (GO:2001044)2.47352099
156hyaluronan catabolic process (GO:0030214)2.46610161
157establishment of integrated proviral latency (GO:0075713)2.46234344
158protein heterotrimerization (GO:0070208)2.46048098
159superoxide anion generation (GO:0042554)2.46011784
160regulation of macrophage cytokine production (GO:0010935)2.45912390
161regulation of fever generation (GO:0031620)2.45465676
162negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.45092519
163collecting duct development (GO:0072044)2.44254760
164regulation of heat generation (GO:0031650)2.44168557
165regulation of anoikis (GO:2000209)2.43994838
166retina vasculature morphogenesis in camera-type eye (GO:0061299)2.43630459
167positive regulation of positive chemotaxis (GO:0050927)2.42961446
168positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.42830873
169eosinophil chemotaxis (GO:0048245)2.42519849
170lung morphogenesis (GO:0060425)2.42486732
171glomerular visceral epithelial cell development (GO:0072015)2.42338913
172cortical cytoskeleton organization (GO:0030865)2.41739401
173lipopolysaccharide biosynthetic process (GO:0009103)2.41302377
174lysine metabolic process (GO:0006553)2.41286192
175lysine catabolic process (GO:0006554)2.41286192
176myeloid cell activation involved in immune response (GO:0002275)2.41234772
177positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.40776133
178regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.39392098
179negative regulation of lipid storage (GO:0010888)2.38101146
180mannose metabolic process (GO:0006013)2.37954780
181positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.37664230
182decidualization (GO:0046697)2.36541472
183positive regulation of calcium ion import (GO:0090280)2.36208463
184cellular response to thyroid hormone stimulus (GO:0097067)2.35462342
185regulation of macrophage chemotaxis (GO:0010758)2.32536007

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human4.51892446
2TRIM28_21343339_ChIP-Seq_HEK293_Human3.77202071
3IRF8_21731497_ChIP-ChIP_J774_Mouse3.50569576
4BP1_19119308_ChIP-ChIP_Hs578T_Human3.44506113
5Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.27264156
6IRF8_22096565_ChIP-ChIP_GC-B_Human3.11267267
7* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.06798381
8IRF8_27001747_Chip-Seq_BMDM_Mouse3.02279318
9TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.82831426
10ESR1_21235772_ChIP-Seq_MCF-7_Human2.80791069
11CDX2_19796622_ChIP-Seq_MESCs_Mouse2.63360972
12* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human2.58082782
13ZNF263_19887448_ChIP-Seq_K562_Human2.53399646
14RARG_19884340_ChIP-ChIP_MEFs_Mouse2.46952548
15* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.35366385
16* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.30582342
17* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human2.28435203
18CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.18126940
19SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.97332939
20* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.96658389
21* ATF3_27146783_Chip-Seq_COLON_Human1.89166085
22* VDR_24787735_ChIP-Seq_THP-1_Human1.87503034
23DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.86495666
24SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.86146800
25* GATA2_21666600_ChIP-Seq_HMVEC_Human1.85330114
26PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.83491522
27WT1_19549856_ChIP-ChIP_CCG9911_Human1.77855622
28CJUN_26792858_Chip-Seq_BT549_Human1.75854571
29ESR2_21235772_ChIP-Seq_MCF-7_Human1.72901626
30MYB_21317192_ChIP-Seq_ERMYB_Mouse1.67927539
31EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.66963451
32BRD4_25478319_ChIP-Seq_HGPS_Human1.65783155
33STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.64868465
34RACK7_27058665_Chip-Seq_MCF-7_Human1.63123531
35* SOX2_20726797_ChIP-Seq_SW620_Human1.61994630
36POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.59243188
37PPAR_26484153_Chip-Seq_NCI-H1993_Human1.54708916
38* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.53985497
39FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.53773004
40KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.53341900
41NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.53323578
42HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.52446743
43NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.52132983
44ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.47008394
45ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.46843927
46CDX2_20551321_ChIP-Seq_CACO-2_Human1.46510087
47TP53_22127205_ChIP-Seq_IMR90_Human1.45761699
48NRF2_20460467_ChIP-Seq_MEFs_Mouse1.44985500
49NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.44985500
50MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.44675593
51PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.43838012
52FOXO3_23340844_ChIP-Seq_DLD1_Human1.43696139
53CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.43311115
54CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.42572016
55ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.40276888
56PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.40234581
57STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.39030051
58EGR1_19374776_ChIP-ChIP_THP-1_Human1.38924372
59CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.37428362
60IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.36441904
61* PU_27001747_Chip-Seq_BMDM_Mouse1.35132425
62MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.34755231
63TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.33798880
64* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.31939456
65* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.31939456
66TP53_18474530_ChIP-ChIP_U2OS_Human1.30682306
67P63_26484246_Chip-Seq_KERATINOCYTES_Human1.30347218
68* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.28414592
69TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.27867457
70FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.24495131
71ZNF217_24962896_ChIP-Seq_MCF-7_Human1.24310553
72STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.23303683
73TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.20260830
74JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.18797298
75NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.17771106
76JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.17191276
77AR_21909140_ChIP-Seq_LNCAP_Human1.17186346
78WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.15933037
79SOX9_24532713_ChIP-Seq_HFSC_Mouse1.15290858
80NFIB_24661679_ChIP-Seq_LUNG_Mouse1.13815636
81GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13136242
82SMAD_19615063_ChIP-ChIP_OVARY_Human1.11839681
83NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.11468264
84EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.11370260
85* CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.09488176
86RXR_22108803_ChIP-Seq_LS180_Human1.07876098
87BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.07647239
88ELK1_22589737_ChIP-Seq_MCF10A_Human1.06208326
89RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.06030119
90SALL4_18804426_ChIP-ChIP_XEN_Mouse1.05442239
91VDR_24763502_ChIP-Seq_THP-1_Human1.05207735
92VDR_22108803_ChIP-Seq_LS180_Human1.03928735
93SRY_22984422_ChIP-ChIP_TESTIS_Rat1.02518208
94STAT3_1855785_ChIP-Seq_MESCs_Mouse1.02293754
95KLF4_18555785_ChIP-Seq_MESCs_Mouse1.01530323
96PIAS1_25552417_ChIP-Seq_VCAP_Human1.01516118
97CLOCK_20551151_ChIP-Seq_293T_Human1.00568922
98CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.98851582
99SMAD3_21741376_ChIP-Seq_HESCs_Human0.98314613
100TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.97933596
101* UBF1/2_26484160_Chip-Seq_HMECs_Human0.97627911
102AHR_22903824_ChIP-Seq_MCF-7_Human0.97050503
103NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.96934792
104PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.96185932
105TP63_23658742_ChIP-Seq_EP156T_Human0.96096437
106SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.95962761
107SCL_19346495_ChIP-Seq_HPC-7_Human0.95068001
108ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.94310545
109* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.93818605
110SMC3_22415368_ChIP-Seq_MEFs_Mouse0.93599158
111NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.91529913
112* SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.91421095
113* MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.89944947
114CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.89781830
115ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.89700380
116CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.87866532
117* ELK3_25401928_ChIP-Seq_HUVEC_Human0.87800476
118TBX20_22080862_ChIP-Seq_HEART_Mouse0.87663710
119TBX20_22328084_ChIP-Seq_HEART_Mouse0.87663710
120SPI1_23127762_ChIP-Seq_K562_Human0.87656405
121TP53_23651856_ChIP-Seq_MEFs_Mouse0.87381003
122SOX2_27498859_Chip-Seq_STOMACH_Mouse0.86731149
123ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.86006882
124TFEB_21752829_ChIP-Seq_HELA_Human0.84764353
125NELFA_20434984_ChIP-Seq_ESCs_Mouse0.84757523
126* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.84686873
127CSB_26484114_Chip-Seq_FIBROBLAST_Human0.84309557
128STAT6_21828071_ChIP-Seq_BEAS2B_Human0.83219525
129E2F1_18555785_ChIP-Seq_MESCs_Mouse0.83058867
130NANOG_18555785_ChIP-Seq_MESCs_Mouse0.82562920
131LXR_22292898_ChIP-Seq_THP-1_Human0.82406217
132* TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.82022926
133TET1_21451524_ChIP-Seq_MESCs_Mouse0.81528341
134VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.81272597
135STAT4_19710469_ChIP-ChIP_TH1__Mouse0.80271505
136HIF1A_21447827_ChIP-Seq_MCF-7_Human0.80201923
137THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.79491575
138* KDM2B_26808549_Chip-Seq_SUP-B15_Human0.78814086
139GATA4_25053715_ChIP-Seq_YYC3_Human0.78095693
140SMC1_22415368_ChIP-Seq_MEFs_Mouse0.77862509
141RUNX_20019798_ChIP-Seq_JUKART_Human0.77767667
142EGR1_19032775_ChIP-ChIP_M12_Human0.76821955
143* P300_27058665_Chip-Seq_ZR-75-30cells_Human0.76700006
144ARNT_22903824_ChIP-Seq_MCF-7_Human0.75830008
145* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.75621280
146GATA2_19941826_ChIP-Seq_K562_Human0.75041333
147* RNF2_18974828_ChIP-Seq_MESCs_Mouse0.73770287
148* EZH2_18974828_ChIP-Seq_MESCs_Mouse0.73770287
149FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.72096291
150LXR_22158963_ChIP-Seq_LIVER_Mouse0.71853153

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005058_abnormal_lysosome_morphology4.05172037
2MP0003195_calcinosis3.48615600
3MP0002877_abnormal_melanocyte_morpholog3.30846007
4MP0005257_abnormal_intraocular_pressure3.28781302
5MP0003303_peritoneal_inflammation3.27996269
6MP0001958_emphysema3.11639226
7MP0003950_abnormal_plasma_membrane3.03344261
8MP0004043_abnormal_pH_regulation2.95960191
9MP0008438_abnormal_cutaneous_collagen2.95915639
10MP0003300_gastrointestinal_ulcer2.76629160
11MP0009840_abnormal_foam_cell2.65883931
12MP0004019_abnormal_vitamin_homeostasis2.61611382
13MP0003724_increased_susceptibility_to2.27046557
14MP0006054_spinal_hemorrhage2.26719617
15MP0002138_abnormal_hepatobiliary_system2.22907518
16MP0001756_abnormal_urination2.21128087
17MP0002136_abnormal_kidney_physiology2.20409045
18MP0009643_abnormal_urine_homeostasis2.17039838
19MP0003136_yellow_coat_color2.09811051
20MP0001765_abnormal_ion_homeostasis2.09614881
21MP0006082_CNS_inflammation2.08302827
22MP0005360_urolithiasis2.03749539
23MP0003172_abnormal_lysosome_physiology2.03043417
24MP0005623_abnormal_meninges_morphology1.96311950
25MP0003566_abnormal_cell_adhesion1.95019741
26MP0010368_abnormal_lymphatic_system1.93486994
27MP0005332_abnormal_amino_acid1.89267241
28MP0005275_abnormal_skin_tensile1.87308300
29MP0009053_abnormal_anal_canal1.83542272
30* MP0003436_decreased_susceptibility_to1.83207283
31MP0002998_abnormal_bone_remodeling1.81428549
32MP0009780_abnormal_chondrocyte_physiolo1.80891304
33MP0000762_abnormal_tongue_morphology1.79208570
34MP0005174_abnormal_tail_pigmentation1.77872697
35MP0001849_ear_inflammation1.76956768
36MP0000538_abnormal_urinary_bladder1.68378992
37MP0004272_abnormal_basement_membrane1.67543724
38* MP0002419_abnormal_innate_immunity1.65157771
39* MP0005164_abnormal_response_to1.52643649
40MP0010352_gastrointestinal_tract_polyps1.49248197
41MP0002933_joint_inflammation1.48301845
42MP0010030_abnormal_orbit_morphology1.47019349
43MP0009764_decreased_sensitivity_to1.46320150
44* MP0005000_abnormal_immune_tolerance1.44391609
45MP0005409_darkened_coat_color1.42385406
46* MP0001533_abnormal_skeleton_physiology1.41697724
47MP0003191_abnormal_cellular_cholesterol1.40082025
48MP0002148_abnormal_hypersensitivity_rea1.39132672
49MP0002254_reproductive_system_inflammat1.38712827
50MP0005636_abnormal_mineral_homeostasis1.37958348
51MP0009785_altered_susceptibility_to1.37520488
52MP0000343_altered_response_to1.36819483
53MP0000569_abnormal_digit_pigmentation1.36113917
54MP0001243_abnormal_dermal_layer1.34193721
55MP0000733_abnormal_muscle_development1.34085455
56MP0001216_abnormal_epidermal_layer1.33904093
57MP0000749_muscle_degeneration1.33519802
58* MP0003448_altered_tumor_morphology1.33020521
59MP0003279_aneurysm1.32369320
60MP0002168_other_aberrant_phenotype1.31031836
61MP0002332_abnormal_exercise_endurance1.28118358
62* MP0000751_myopathy1.27444019
63MP0004381_abnormal_hair_follicle1.24855353
64MP0001299_abnormal_eye_distance/1.24854523
65MP0000579_abnormal_nail_morphology1.24823151
66MP0003091_abnormal_cell_migration1.24186345
67MP0000537_abnormal_urethra_morphology1.22732244
68MP0008260_abnormal_autophagy1.22655484
69MP0001835_abnormal_antigen_presentation1.21628980
70MP0005451_abnormal_body_composition1.20506203
71MP0000015_abnormal_ear_pigmentation1.19719080
72MP0005464_abnormal_platelet_physiology1.19064500
73MP0001790_abnormal_immune_system1.17157927
74MP0005387_immune_system_phenotype1.17157927
75MP0000465_gastrointestinal_hemorrhage1.15991522
76MP0002135_abnormal_kidney_morphology1.13716779
77MP0003329_amyloid_beta_deposits1.12713441
78MP0002896_abnormal_bone_mineralization1.11965418
79MP0003795_abnormal_bone_structure1.10833554
80MP0005167_abnormal_blood-brain_barrier1.10687057
81MP0009278_abnormal_bone_marrow1.10521741
82MP0010386_abnormal_urinary_bladder1.08160007
83MP0003828_pulmonary_edema1.03857845
84MP0005508_abnormal_skeleton_morphology1.03690408
85MP0000534_abnormal_ureter_morphology1.02326050
86* MP0008469_abnormal_protein_level1.02185674
87* MP0005025_abnormal_response_to1.02152488
88* MP0001845_abnormal_inflammatory_respons1.00720393
89* MP0002452_abnormal_antigen_presenting1.00141460
90MP0002277_abnormal_respiratory_mucosa0.99605875
91* MP0000750_abnormal_muscle_regeneration0.99451572
92MP0002928_abnormal_bile_duct0.99188567
93MP0010234_abnormal_vibrissa_follicle0.98671661
94MP0003806_abnormal_nucleotide_metabolis0.97649991
95MP0003453_abnormal_keratinocyte_physiol0.94623822
96MP0000467_abnormal_esophagus_morphology0.94244272
97MP0001915_intracranial_hemorrhage0.93365185
98MP0000767_abnormal_smooth_muscle0.92664061
99MP0005165_increased_susceptibility_to0.92564035
100* MP0005390_skeleton_phenotype0.91996372
101MP0003045_fibrosis0.90944595
102MP0002098_abnormal_vibrissa_morphology0.90590266
103MP0005377_hearing/vestibular/ear_phenot0.90207168
104MP0003878_abnormal_ear_physiology0.90207168
105MP0003941_abnormal_skin_development0.89326935
106MP0003690_abnormal_glial_cell0.89302006
107MP0002295_abnormal_pulmonary_circulatio0.89014478
108MP0000627_abnormal_mammary_gland0.88584666
109MP0000604_amyloidosis0.88293568
110MP0004742_abnormal_vestibular_system0.88052356
111MP0010771_integument_phenotype0.87408528
112MP0004510_myositis0.87253815
113MP0003075_altered_response_to0.86519713
114MP0004883_abnormal_blood_vessel0.86246244
115MP0005503_abnormal_tendon_morphology0.85805143
116MP0001853_heart_inflammation0.85416661
117MP0004858_abnormal_nervous_system0.84555881
118MP0005501_abnormal_skin_physiology0.84378918
119MP0005023_abnormal_wound_healing0.83615231
120MP0003705_abnormal_hypodermis_morpholog0.82156912
121MP0002115_abnormal_skeleton_extremities0.82078281
122* MP0002723_abnormal_immune_serum0.81734731
123MP0001851_eye_inflammation0.81433003
124MP0004947_skin_inflammation0.81269856
125MP0001879_abnormal_lymphatic_vessel0.80470354
126MP0000013_abnormal_adipose_tissue0.79811564
127MP0005595_abnormal_vascular_smooth0.78429260
128MP0005310_abnormal_salivary_gland0.77349328
129MP0005166_decreased_susceptibility_to0.76316284
130* MP0000858_altered_metastatic_potential0.75985407
131MP0005621_abnormal_cell_physiology0.75918619
132MP0004233_abnormal_muscle_weight0.75705438
133MP0002089_abnormal_postnatal_growth/wei0.75239902
134* MP0005197_abnormal_uvea_morphology0.74701022
135MP0002060_abnormal_skin_morphology0.74099364
136MP0000249_abnormal_blood_vessel0.73866444
137MP0002796_impaired_skin_barrier0.73151960
138MP0001663_abnormal_digestive_system0.72708297
139MP0005330_cardiomyopathy0.72287145
140* MP0001614_abnormal_blood_vessel0.71520817
141MP0000759_abnormal_skeletal_muscle0.70940931
142MP0000371_diluted_coat_color0.69821165
143MP0002405_respiratory_system_inflammati0.69599821
144MP0000163_abnormal_cartilage_morphology0.69144411
145MP0001542_abnormal_bone_strength0.68190488
146MP0000613_abnormal_salivary_gland0.67885679
147MP0008007_abnormal_cellular_replicative0.67423500
148MP0005193_abnormal_anterior_eye0.66866752
149* MP0002177_abnormal_outer_ear0.66073390
150MP0002113_abnormal_skeleton_development0.63497835

Predicted human phenotypes

RankGene SetZ-score
1Metabolic alkalosis (HP:0200114)6.68635492
2Hypokalemic alkalosis (HP:0001949)5.88256951
3Hypomagnesemia (HP:0002917)5.75369143
4Increased circulating renin level (HP:0000848)5.44855887
5Abnormality of chloride homeostasis (HP:0011422)5.38815944
6Hyperactive renin-angiotensin system (HP:0000841)5.36730161
7Vacuolated lymphocytes (HP:0001922)5.16021697
8Polyuria (HP:0000103)5.10312381
9Abnormality of magnesium homeostasis (HP:0004921)4.95920125
10Abnormal urine output (HP:0012590)4.75801543
11Protrusio acetabuli (HP:0003179)4.63406765
12Tetany (HP:0001281)4.54567112
13Abnormality of renal excretion (HP:0011036)4.39969949
14Follicular hyperkeratosis (HP:0007502)4.10218987
15Polydipsia (HP:0001959)3.96776532
16Abnormal drinking behavior (HP:0030082)3.96776532
17Hyperaldosteronism (HP:0000859)3.82913011
18Dysostosis multiplex (HP:0000943)3.75253611
19Renal salt wasting (HP:0000127)3.68792466
20Increased cerebral lipofuscin (HP:0011813)3.66642855
21Fragile skin (HP:0001030)3.66282745
22Onycholysis (HP:0001806)3.57095521
23Achilles tendon contracture (HP:0001771)3.55559601
24Abnormality of renin-angiotensin system (HP:0000847)3.53200631
25Ankle contracture (HP:0006466)3.52950590
26Spinal rigidity (HP:0003306)3.50956339
27Fragile nails (HP:0001808)3.47304559
28Alkalosis (HP:0001948)3.43608305
29Milia (HP:0001056)3.38344949
30Mucopolysacchariduria (HP:0008155)3.30955004
31Urinary glycosaminoglycan excretion (HP:0003541)3.30955004
32Short nail (HP:0001799)3.30197905
33Axonal loss (HP:0003447)3.29567134
34Increased neuronal autofluorescent lipopigment (HP:0002074)3.20999442
35Abnormality of the Achilles tendon (HP:0005109)3.11141365
36Gout (HP:0001997)3.08684232
37Abnormality of mucopolysaccharide metabolism (HP:0011020)3.08504144
38Abnormality of polysaccharide metabolism (HP:0011012)3.08504144
39Abnormality of glycosaminoglycan metabolism (HP:0004371)3.08504144
40Abnormality of glutamine family amino acid metabolism (HP:0010902)3.01654139
41Abnormality of macrophages (HP:0004311)3.00912737
42Type 1 muscle fiber predominance (HP:0003803)2.99068263
43Distal lower limb amyotrophy (HP:0008944)2.98115037
44Premature rupture of membranes (HP:0001788)2.95724613
45Renal tubular acidosis (HP:0001947)2.87402917
46Reduced subcutaneous adipose tissue (HP:0003758)2.86753377
47Hypokalemia (HP:0002900)2.82351113
48Recurrent abscess formation (HP:0002722)2.80842836
49Slender build (HP:0001533)2.79596097
50Distal upper limb amyotrophy (HP:0007149)2.78516964
51Upper limb amyotrophy (HP:0009129)2.78516964
52Mildly elevated creatine phosphokinase (HP:0008180)2.77668381
53Increased connective tissue (HP:0009025)2.73638312
54Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.72605893
55Generalized amyotrophy (HP:0003700)2.71682603
56Neurofibrillary tangles (HP:0002185)2.70738852
57Distal lower limb muscle weakness (HP:0009053)2.67014926
58Systemic lupus erythematosus (HP:0002725)2.63931041
59Abnormality of proline metabolism (HP:0010907)2.62087967
60Hydroxyprolinuria (HP:0003080)2.62087967
61Abnormality of dentin (HP:0010299)2.61348347
62Aortic dissection (HP:0002647)2.61339561
63Elbow flexion contracture (HP:0002987)2.60816510
64Natal tooth (HP:0000695)2.59131058
65Hypercalciuria (HP:0002150)2.58991689
66Bladder diverticulum (HP:0000015)2.58769374
67Hyperuricemia (HP:0002149)2.55465585
68Increased purine levels (HP:0004368)2.55465585
69Wormian bones (HP:0002645)2.53954803
70Abnormality of the umbilical cord (HP:0010881)2.52269960
71Amyloidosis (HP:0011034)2.51511145
72Glucose intolerance (HP:0000833)2.46374551
73Abnormality of glycolipid metabolism (HP:0010969)2.45433034
74Abnormality of liposaccharide metabolism (HP:0010968)2.45433034
75Abnormality of glycosphingolipid metabolism (HP:0004343)2.45433034
76Deep venous thrombosis (HP:0002625)2.43979255
77Nail dystrophy (HP:0008404)2.43461381
78Prostate neoplasm (HP:0100787)2.41244791
79Myocardial infarction (HP:0001658)2.39376727
80Difficulty climbing stairs (HP:0003551)2.38916414
81Blue sclerae (HP:0000592)2.38038818
82Abnormality of purine metabolism (HP:0004352)2.37580308
83Eczematoid dermatitis (HP:0000976)2.32257039
84Abnormality of potassium homeostasis (HP:0011042)2.31997758
85Abnormality of the distal phalanges of the toes (HP:0010182)2.30434270
86Disinhibition (HP:0000734)2.25738140
87Alopecia of scalp (HP:0002293)2.25477982
88Hand muscle atrophy (HP:0009130)2.24490008
89Hypophosphatemia (HP:0002148)2.23339579
90Proximal tubulopathy (HP:0000114)2.22416253
91Recurrent bacterial skin infections (HP:0005406)2.21153333
92Cerebral inclusion bodies (HP:0100314)2.20922106
93Glomerulonephritis (HP:0000099)2.20179097
94Plantar hyperkeratosis (HP:0007556)2.18584141
95Trismus (HP:0000211)2.18139871
96Cervical subluxation (HP:0003308)2.16045439
97Tubular atrophy (HP:0000092)2.15103376
98Genu recurvatum (HP:0002816)2.12187050
99Soft skin (HP:0000977)2.11141627
100Interstitial pulmonary disease (HP:0006530)2.10136756
101Lower limb amyotrophy (HP:0007210)2.09750742
102Aortic aneurysm (HP:0004942)2.06658549
103Abnormality of Sharpey fibers (HP:0100685)2.04691483
104Broad face (HP:0000283)2.03688336
105Abnormal umbilical cord blood vessels (HP:0011403)2.03100629
106Single umbilical artery (HP:0001195)2.03100629
107Abnormality of the fetal cardiovascular system (HP:0010948)2.03100629
108Joint stiffness (HP:0001387)2.02844500
109Abnormalities of placenta or umbilical cord (HP:0001194)2.02339735
110Persistence of primary teeth (HP:0006335)2.00826050
111Thick nail (HP:0001805)2.00225573
112Limb-girdle muscle atrophy (HP:0003797)2.00217460
113Ankyloglossia (HP:0010296)1.97890700
114Dilatation of the ascending aorta (HP:0005111)1.96565093
115Adrenal overactivity (HP:0002717)1.96482672
116Abnormality of oral frenula (HP:0000190)1.95602713
117Increased variability in muscle fiber diameter (HP:0003557)1.95585709
118Pathologic fracture (HP:0002756)1.95204656
119Nuclear cataract (HP:0100018)1.94241305
120Hydroureter (HP:0000072)1.93373211
121Cardiovascular calcification (HP:0011915)1.93173022
122Chondrocalcinosis (HP:0000934)1.91928713
123Arterial tortuosity (HP:0005116)1.91681169
124Atrophic scars (HP:0001075)1.90970819
125Dehydration (HP:0001944)1.90552475
126Osteolytic defects of the phalanges of the hand (HP:0009771)1.89365964
127Osteolytic defects of the hand bones (HP:0009699)1.89365964
128Recurrent gram-negative bacterial infections (HP:0005420)1.88055121
129Upper limb muscle weakness (HP:0003484)1.87660545
130Nephritis (HP:0000123)1.87484325
131Thin bony cortex (HP:0002753)1.87122759
132Peritonitis (HP:0002586)1.86602017
133Hyperglycinuria (HP:0003108)1.86367411
134Abnormality of skeletal muscle fiber size (HP:0012084)1.85652387
135Joint laxity (HP:0001388)1.85561017
136Mitral valve prolapse (HP:0001634)1.85502676
137Bone pain (HP:0002653)1.85178745
138Vascular tortuosity (HP:0004948)1.84104997
139Vascular calcification (HP:0004934)1.83968065
140Pterygium (HP:0001059)1.83615862
141Abnormality of sodium homeostasis (HP:0010931)1.82785729
142Protruding ear (HP:0000411)1.82392246
143Acanthosis nigricans (HP:0000956)1.81386655
144Rough bone trabeculation (HP:0100670)1.80887954
145Femoral bowing (HP:0002980)1.80679392
146Long toe (HP:0010511)1.80628173
147Nephrocalcinosis (HP:0000121)1.80324284
148Limb-girdle muscle weakness (HP:0003325)1.79799445
149Abnormal urine phosphate concentration (HP:0012599)1.79013392
150Obstructive lung disease (HP:0006536)1.78661769
151Chronic obstructive pulmonary disease (HP:0006510)1.78661769
152Selective tooth agenesis (HP:0001592)1.77767903
153Craniofacial hyperostosis (HP:0004493)1.77475164
154Hypoplasia of the iris (HP:0007676)1.77208789
155Osteopenia (HP:0000938)1.75245945
156Entropion (HP:0000621)1.74743101
157Spondylolisthesis (HP:0003302)1.74701847
158Cerebral aneurysm (HP:0004944)1.74103234
159Hyperacusis (HP:0010780)1.73698251
160Long palpebral fissure (HP:0000637)1.72161098
161Renal tubular dysfunction (HP:0000124)1.68399281
162Orchitis (HP:0100796)1.67817399
163Hypophosphatemic rickets (HP:0004912)1.65122309
164Gingivitis (HP:0000230)1.63823055
165Bilateral sensorineural hearing impairment (HP:0008619)1.63567289
166Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.62787717
167J-shaped sella turcica (HP:0002680)1.60399760
168Vertebral compression fractures (HP:0002953)1.60191393
169Basal ganglia calcification (HP:0002135)1.60175056
170Stomatitis (HP:0010280)1.58519966
171Tubulointerstitial fibrosis (HP:0005576)1.57201409
172Thoracic kyphosis (HP:0002942)1.56650173
173Progressive visual loss (HP:0000529)1.56116214

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK35.56994583
2OXSR14.80418166
3WNK44.12143551
4TESK13.54225130
5TGFBR23.32540135
6LIMK13.31865062
7IRAK32.70438230
8NME22.67587388
9TTN2.67086950
10CASK2.60108357
11LMTK22.58956514
12TESK22.51310458
13MKNK22.35590458
14BLK2.04188150
15NTRK12.03854958
16KIT2.02346823
17ARAF2.02168759
18STK391.96105493
19PDGFRA1.94956962
20MAP3K141.87687450
21IRAK41.79641530
22SIK11.76705980
23TBK11.68895965
24TLK11.65559335
25MAP3K31.61690377
26TAOK21.54405681
27EPHB11.50699362
28LRRK21.45320547
29MST1R1.42395674
30VRK21.40685190
31CSK1.40256547
32PIK3CG1.38071583
33FES1.33774518
34MST41.28167759
35NEK91.25398960
36TYK21.25375865
37FLT31.25310843
38FER1.24754772
39PAK21.23829992
40ERN11.22814433
41GSK3A1.11189169
42MKNK11.11025249
43PIM21.07347753
44BMX1.07025372
45TAOK31.01979862
46IRAK10.99753737
47LATS20.98118979
48CDK80.97881376
49RIPK40.97869899
50CAMKK20.95658172
51PTK60.92961374
52MAP3K120.92645541
53PTK20.89932359
54IRAK20.89021549
55TRPM70.88627735
56STK100.88626841
57MAP2K30.86817795
58IKBKB0.86752076
59ICK0.85270433
60MOS0.84388035
61FGR0.83673829
62BUB10.83115978
63GRK50.82814608
64ROCK20.81703045
65TRIB30.79486376
66HCK0.78200348
67ABL20.75404665
68IKBKE0.75238616
69PRKD20.71696388
70WNK10.69471148
71SMG10.67805313
72ADRBK10.66931766
73NEK10.66399733
74EPHA20.65510572
75ILK0.65218268
76ABL10.63094343
77SGK2230.62056529
78SGK4940.62056529
79STK380.61413021
80PRPF4B0.60619920
81MAPK150.60608424
82DDR20.60224800
83PAK40.59946640
84ROCK10.59370502
85PBK0.59108329
86CAMK1D0.57347873
87SCYL20.56411534
88CSF1R0.55636701
89MAP3K80.55455738
90CAMK1G0.55245986
91RIPK10.54722355
92LCK0.54174913
93PRKG20.53538647
94DYRK1B0.53297311
95RPS6KA40.52659191
96JAK10.52362090
97MAP3K110.51140959
98DAPK10.51101477
99CDC42BPA0.48755952
100MYLK0.48746923
101GRK70.47984618
102CDK60.47539279
103PRKAA20.46479785
104PRKCD0.45650198
105MATK0.45173377
106MAPKAPK20.45015834
107SIK30.44840162
108STK30.44596656
109LYN0.44468097
110ERBB40.44325372
111LATS10.43642801
112BRAF0.42303308
113AURKA0.41214430
114DMPK0.40778508
115MAP2K20.40274908
116JAK20.40081998
117PHKG10.39761886
118PHKG20.39761886
119EGFR0.38805250
120PDGFRB0.38645548
121CHUK0.37870807
122BRSK10.37610631
123DAPK30.37164658
124EPHB20.36979576
125TEC0.36967842
126SGK30.36344575
127PAK10.36189467
128ZAP700.36064056
129INSR0.35353718
130PKN10.35270273
131MET0.35169750
132PTK2B0.34392881
133KDR0.34207625
134SGK20.34170162
135ITK0.34096765
136EIF2AK20.32887299
137HIPK20.32740666
138NLK0.32645864
139RPS6KA20.31306794
140MAP3K130.30249113
141MTOR0.30201576
142CDK70.29041591
143CAMK2G0.26850270
144PRKCI0.24562539
145MAPKAPK30.24283685
146CDK90.23834529
147CDK180.23292316
148CDK140.23084522
149MELK0.22747929
150CDK150.22297420
151MAP3K10.22142985

Predicted pathways (KEGG)

RankGene SetZ-score
1Other glycan degradation_Homo sapiens_hsa005114.06132834
2Glycosaminoglycan degradation_Homo sapiens_hsa005313.51688346
3Lysosome_Homo sapiens_hsa041423.08952048
4Malaria_Homo sapiens_hsa051442.44321625
5Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005122.32643181
6Phagosome_Homo sapiens_hsa041452.23675853
7Leishmaniasis_Homo sapiens_hsa051402.14924574
8Staphylococcus aureus infection_Homo sapiens_hsa051502.12080795
9Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.11386516
10Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.03806292
11ECM-receptor interaction_Homo sapiens_hsa045122.03533374
12Collecting duct acid secretion_Homo sapiens_hsa049662.01092172
13Rheumatoid arthritis_Homo sapiens_hsa053231.93959110
14Galactose metabolism_Homo sapiens_hsa000521.87417062
15Sphingolipid metabolism_Homo sapiens_hsa006001.87384713
16Pentose and glucuronate interconversions_Homo sapiens_hsa000401.81321343
17Osteoclast differentiation_Homo sapiens_hsa043801.80016013
18Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.76734292
19Proteasome_Homo sapiens_hsa030501.74572801
20Toll-like receptor signaling pathway_Homo sapiens_hsa046201.71908182
21Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.69933509
22N-Glycan biosynthesis_Homo sapiens_hsa005101.67656681
23Tuberculosis_Homo sapiens_hsa051521.58240573
24Protein digestion and absorption_Homo sapiens_hsa049741.53493603
25Pertussis_Homo sapiens_hsa051331.51729271
26Vitamin digestion and absorption_Homo sapiens_hsa049771.51353225
27Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.50632649
28Leukocyte transendothelial migration_Homo sapiens_hsa046701.45335565
29Focal adhesion_Homo sapiens_hsa045101.42152041
30Central carbon metabolism in cancer_Homo sapiens_hsa052301.41397377
31Pentose phosphate pathway_Homo sapiens_hsa000301.40239480
32Mineral absorption_Homo sapiens_hsa049781.36634676
33Amoebiasis_Homo sapiens_hsa051461.34344861
34Dilated cardiomyopathy_Homo sapiens_hsa054141.33696747
35Cyanoamino acid metabolism_Homo sapiens_hsa004601.29148843
36Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.28528815
37Fructose and mannose metabolism_Homo sapiens_hsa000511.23369654
38Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.22268076
39* NF-kappa B signaling pathway_Homo sapiens_hsa040641.19589609
40AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.16215126
41Prion diseases_Homo sapiens_hsa050201.15851577
42Thyroid cancer_Homo sapiens_hsa052161.14899945
43Adherens junction_Homo sapiens_hsa045201.13710388
44Renin-angiotensin system_Homo sapiens_hsa046141.13710173
45Toxoplasmosis_Homo sapiens_hsa051451.13200031
46Hematopoietic cell lineage_Homo sapiens_hsa046401.12668477
47Regulation of actin cytoskeleton_Homo sapiens_hsa048101.12660758
48Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.07623403
49Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.06787826
50Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.04954109
51* Complement and coagulation cascades_Homo sapiens_hsa046101.04226295
52Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.03372162
53Viral myocarditis_Homo sapiens_hsa054161.02289467
54Sulfur metabolism_Homo sapiens_hsa009201.00980360
55Small cell lung cancer_Homo sapiens_hsa052220.99940244
56Shigellosis_Homo sapiens_hsa051310.98329925
57TNF signaling pathway_Homo sapiens_hsa046680.94353845
58Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.93436137
59Salmonella infection_Homo sapiens_hsa051320.90978320
60Hepatitis C_Homo sapiens_hsa051600.90613122
61Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.89076196
62* Proteoglycans in cancer_Homo sapiens_hsa052050.87820593
63Arachidonic acid metabolism_Homo sapiens_hsa005900.86781748
64Melanoma_Homo sapiens_hsa052180.85831550
65p53 signaling pathway_Homo sapiens_hsa041150.85105338
66Apoptosis_Homo sapiens_hsa042100.85032087
67Biosynthesis of amino acids_Homo sapiens_hsa012300.84960103
68Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.83312305
69Measles_Homo sapiens_hsa051620.81889159
70Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.81516024
71B cell receptor signaling pathway_Homo sapiens_hsa046620.80677361
72Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.79112850
73NOD-like receptor signaling pathway_Homo sapiens_hsa046210.78720348
74Hippo signaling pathway_Homo sapiens_hsa043900.77783709
75Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.76789879
76Pathways in cancer_Homo sapiens_hsa052000.76746055
77Peroxisome_Homo sapiens_hsa041460.74004140
78Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.73390462
79Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.71122454
80Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.70912915
81Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.69951671
82Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.69638961
83Graft-versus-host disease_Homo sapiens_hsa053320.69396239
84Glutathione metabolism_Homo sapiens_hsa004800.69043204
85Bladder cancer_Homo sapiens_hsa052190.68512616
86Pancreatic cancer_Homo sapiens_hsa052120.68349898
87Fatty acid elongation_Homo sapiens_hsa000620.67409313
88Prostate cancer_Homo sapiens_hsa052150.66662415
89Asthma_Homo sapiens_hsa053100.66415409
90PI3K-Akt signaling pathway_Homo sapiens_hsa041510.64480516
91Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.64464592
92Jak-STAT signaling pathway_Homo sapiens_hsa046300.63793415
93Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.63512759
942-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.63463708
95beta-Alanine metabolism_Homo sapiens_hsa004100.63184704
96Chronic myeloid leukemia_Homo sapiens_hsa052200.62810720
97HTLV-I infection_Homo sapiens_hsa051660.62199118
98Antigen processing and presentation_Homo sapiens_hsa046120.61584428
99PPAR signaling pathway_Homo sapiens_hsa033200.61311151
100Legionellosis_Homo sapiens_hsa051340.60552690
101RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.58816029
102Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.58049183
103Pyrimidine metabolism_Homo sapiens_hsa002400.57911079
104Butanoate metabolism_Homo sapiens_hsa006500.57176807
105Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.57032322
106Bile secretion_Homo sapiens_hsa049760.55337770
107Influenza A_Homo sapiens_hsa051640.54751020
108Platelet activation_Homo sapiens_hsa046110.54530266
109TGF-beta signaling pathway_Homo sapiens_hsa043500.53585703
110Renal cell carcinoma_Homo sapiens_hsa052110.53531316
111Notch signaling pathway_Homo sapiens_hsa043300.53448471
112Vibrio cholerae infection_Homo sapiens_hsa051100.52930652
113Sulfur relay system_Homo sapiens_hsa041220.52594798
114Sphingolipid signaling pathway_Homo sapiens_hsa040710.52518283
115* MicroRNAs in cancer_Homo sapiens_hsa052060.52199824
116Carbohydrate digestion and absorption_Homo sapiens_hsa049730.51897181
117Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.51231950
118Glioma_Homo sapiens_hsa052140.50295377
119Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.49938457
120Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.49684256
121VEGF signaling pathway_Homo sapiens_hsa043700.48797326
122Axon guidance_Homo sapiens_hsa043600.47720586
123Endometrial cancer_Homo sapiens_hsa052130.47081268
124Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.47070551
125Acute myeloid leukemia_Homo sapiens_hsa052210.47014703
126Endocytosis_Homo sapiens_hsa041440.45903482
127Folate biosynthesis_Homo sapiens_hsa007900.45112625
128Choline metabolism in cancer_Homo sapiens_hsa052310.44313716
129African trypanosomiasis_Homo sapiens_hsa051430.44066846
130Lysine degradation_Homo sapiens_hsa003100.43450161
131Basal cell carcinoma_Homo sapiens_hsa052170.43059675
132Hepatitis B_Homo sapiens_hsa051610.43048987
133ErbB signaling pathway_Homo sapiens_hsa040120.42198799
134SNARE interactions in vesicular transport_Homo sapiens_hsa041300.41897016
135Tight junction_Homo sapiens_hsa045300.41119118
136Chemokine signaling pathway_Homo sapiens_hsa040620.40226900
137Allograft rejection_Homo sapiens_hsa053300.40020280
138Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.39601127
139Adipocytokine signaling pathway_Homo sapiens_hsa049200.38764339
140Rap1 signaling pathway_Homo sapiens_hsa040150.38585982
141Phospholipase D signaling pathway_Homo sapiens_hsa040720.38490522
142Intestinal immune network for IgA production_Homo sapiens_hsa046720.38286627
143Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.37600468
144Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.36932686

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