PLB1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a membrane-associated phospholipase that displays lysophospholipase and phospholipase A2 activities through removal of sn-1 and sn-2 fatty acids of glycerophospholipids. In addition, it displays lipase and retinyl ester hydrolase activities. The encoded protein is highly conserved and is composed of a large, glycosylated extracellular domain composed of four tandem homologous domains, followed by a hydrophobic segment that anchors the enzyme to the membrane and a short C-terminal cytoplasmic tail. This gene has been identified as a candidate rheumatoid arthritis risk gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1angiotensin maturation (GO:0002003)6.83293718
2regulation of dendritic cell antigen processing and presentation (GO:0002604)5.39115570
3fusion of sperm to egg plasma membrane (GO:0007342)5.30126084
4lipoprotein transport (GO:0042953)4.98207732
5sperm motility (GO:0030317)4.91416328
6regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)4.90767121
7energy homeostasis (GO:0097009)4.84232090
8superoxide anion generation (GO:0042554)4.78353726
9multicellular organism reproduction (GO:0032504)4.55843031
10antigen processing and presentation of endogenous antigen (GO:0019883)4.46770464
11axonemal dynein complex assembly (GO:0070286)4.41966345
12positive regulation of antigen processing and presentation (GO:0002579)4.38125197
13antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.38117433
14cell wall macromolecule catabolic process (GO:0016998)4.31510371
15cell wall macromolecule metabolic process (GO:0044036)4.31510371
16detection of other organism (GO:0098543)4.28953018
17response to peptidoglycan (GO:0032494)4.28475685
18cilium or flagellum-dependent cell motility (GO:0001539)4.24008184
19negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.17308524
20negative regulation of cell killing (GO:0031342)4.17308524
21regulation of hexokinase activity (GO:1903299)4.15977805
22regulation of glucokinase activity (GO:0033131)4.15977805
23acrosome reaction (GO:0007340)4.14961457
24antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.12411543
25positive regulation of cellular amide metabolic process (GO:0034250)4.12386315
26detection of bacterium (GO:0016045)4.09866668
27regulation of triglyceride catabolic process (GO:0010896)4.08545052
28piRNA metabolic process (GO:0034587)4.03325026
29positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)4.02266450
30acrosome assembly (GO:0001675)4.01036458
31plasma membrane fusion (GO:0045026)3.94243242
32motile cilium assembly (GO:0044458)3.94027567
33reproduction (GO:0000003)3.84427975
34bundle of His cell to Purkinje myocyte communication (GO:0086069)3.83939506
35fat-soluble vitamin biosynthetic process (GO:0042362)3.80390906
36negative regulation of cAMP-mediated signaling (GO:0043951)3.74316891
37lipoxygenase pathway (GO:0019372)3.72570903
38sperm-egg recognition (GO:0035036)3.71638763
39regulation of guanylate cyclase activity (GO:0031282)3.70172058
40negative regulation of myeloid cell apoptotic process (GO:0033033)3.69646528
41spermatid development (GO:0007286)3.69454878
42hydrogen peroxide biosynthetic process (GO:0050665)3.68789795
43positive regulation of heat generation (GO:0031652)3.67687758
44regulation of antigen processing and presentation (GO:0002577)3.64775156
45cell-cell recognition (GO:0009988)3.62226457
46peptide catabolic process (GO:0043171)3.53040640
47response to muramyl dipeptide (GO:0032495)3.51002155
48NIK/NF-kappaB signaling (GO:0038061)3.50794939
49epoxygenase P450 pathway (GO:0019373)3.44387098
50regulation of syncytium formation by plasma membrane fusion (GO:0060142)3.41140659
51regulation of activation of Janus kinase activity (GO:0010533)3.40751107
52regulation of interferon-beta biosynthetic process (GO:0045357)3.38556930
53phospholipid efflux (GO:0033700)3.36788138
54hormone catabolic process (GO:0042447)3.35722637
55reactive oxygen species biosynthetic process (GO:1903409)3.34128683
56plasma lipoprotein particle assembly (GO:0034377)3.32519390
57cellular extravasation (GO:0045123)3.28399745
58epithelial cilium movement (GO:0003351)3.27277410
59positive regulation of type 2 immune response (GO:0002830)3.27126251
60neutrophil activation involved in immune response (GO:0002283)3.26757125
61single fertilization (GO:0007338)3.25499590
62glycosphingolipid catabolic process (GO:0046479)3.25287729
63positive regulation of interleukin-1 beta secretion (GO:0050718)3.24408064
64detection of molecule of bacterial origin (GO:0032490)3.22925889
65intestinal absorption (GO:0050892)3.22451268
66positive regulation of monocyte chemotaxis (GO:0090026)3.19902988
67regulation of fever generation (GO:0031620)3.19828156
68detection of biotic stimulus (GO:0009595)3.19573753
69glycolipid catabolic process (GO:0019377)3.17886026
70regulation of B cell receptor signaling pathway (GO:0050855)3.16719114
71positive regulation of icosanoid secretion (GO:0032305)3.15846679
72binding of sperm to zona pellucida (GO:0007339)3.15718966
73NADH metabolic process (GO:0006734)3.14968772
74regulation of cellular extravasation (GO:0002691)3.14380170
75regulation of gamma-delta T cell activation (GO:0046643)3.13635839
76interferon-gamma secretion (GO:0072643)3.13034605
77positive regulation of CREB transcription factor activity (GO:0032793)3.12953982
78regulation of mast cell degranulation (GO:0043304)3.10430258
79very-low-density lipoprotein particle assembly (GO:0034379)3.09875793
80cellular response to interferon-beta (GO:0035458)3.09478881
81sulfate transport (GO:0008272)3.08187868
82fructose metabolic process (GO:0006000)3.06535291
83negative regulation of interleukin-12 production (GO:0032695)3.04977346
84regulation of necroptotic process (GO:0060544)3.04852088
85positive regulation by symbiont of host defense response (GO:0052509)3.04212710
86modulation by symbiont of host defense response (GO:0052031)3.04212710
87modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.04212710
88modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.04212710
89positive regulation by organism of defense response of other organism involved in symbiotic interact3.04212710
90modulation by symbiont of host immune response (GO:0052553)3.04212710
91regulation of bile acid biosynthetic process (GO:0070857)3.03474592
92kinetochore assembly (GO:0051382)3.02205081
93protein-lipid complex assembly (GO:0065005)3.02052962
94virion attachment to host cell (GO:0019062)3.01002682
95adhesion of symbiont to host cell (GO:0044650)3.01002682
96regulation of myeloid cell apoptotic process (GO:0033032)3.00912074
97positive regulation of interleukin-1 secretion (GO:0050716)3.00359689
98regulation of myeloid leukocyte mediated immunity (GO:0002886)2.99899363
99positive regulation of interleukin-12 production (GO:0032735)2.99301887
100positive regulation of T cell migration (GO:2000406)2.98737154
101production of molecular mediator involved in inflammatory response (GO:0002532)2.97555889
102macrophage activation (GO:0042116)2.95420911
103diacylglycerol metabolic process (GO:0046339)2.94024395
104detection of external biotic stimulus (GO:0098581)2.92562606
105response to host immune response (GO:0052572)2.92289256
106response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.92289256
107antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.92180623
108cilium movement (GO:0003341)2.90500177
109B cell mediated immunity (GO:0019724)2.89852859
110regulation of interleukin-1 beta secretion (GO:0050706)2.89268718
111kinetochore organization (GO:0051383)2.88267829
112leukocyte aggregation (GO:0070486)2.88007643
113myeloid dendritic cell differentiation (GO:0043011)2.87967229
114dendritic cell chemotaxis (GO:0002407)2.87447486
115regulation of RIG-I signaling pathway (GO:0039535)2.87426381
116regulation of leukocyte degranulation (GO:0043300)2.87401299
117regulation of mast cell activation involved in immune response (GO:0033006)2.85772108
118myeloid cell activation involved in immune response (GO:0002275)2.85756504
119cytochrome complex assembly (GO:0017004)2.85589609
120positive regulation of prostaglandin secretion (GO:0032308)2.84581730
121positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.84478330
122positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.84262082
123regulation of gamma-delta T cell differentiation (GO:0045586)2.84249506
124interferon-gamma-mediated signaling pathway (GO:0060333)2.84138384
125regulation of heat generation (GO:0031650)2.83691457
126positive regulation of guanylate cyclase activity (GO:0031284)2.83098538
127regulation of systemic arterial blood pressure by hormone (GO:0001990)2.82849781
128regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)2.82849781
129endocrine process (GO:0050886)2.82849781
130negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class 2.80550172
131neutrophil activation (GO:0042119)2.80007927
132immunoglobulin mediated immune response (GO:0016064)2.78939865
133nucleoside diphosphate catabolic process (GO:0009134)2.78582924
134myeloid dendritic cell activation (GO:0001773)2.77039343
135positive regulation of lymphocyte migration (GO:2000403)2.76510103
136positive regulation of mast cell activation (GO:0033005)2.75846154
137surfactant homeostasis (GO:0043129)2.75591370
138positive regulation of gamma-delta T cell activation (GO:0046645)2.75443757
139negative regulation of lymphocyte mediated immunity (GO:0002707)2.74035944
140leukotriene metabolic process (GO:0006691)2.73285348
141response to host (GO:0075136)2.72245459
142response to host defenses (GO:0052200)2.72245459
143response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.72245459
144macrophage activation involved in immune response (GO:0002281)2.72203845
145positive regulation of triglyceride lipase activity (GO:0061365)2.72103917
146positive regulation of lipoprotein lipase activity (GO:0051006)2.72103917
147regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.71731057
148granulocyte activation (GO:0036230)2.71358733
149microglial cell activation (GO:0001774)2.70990013
150positive regulation of T cell mediated cytotoxicity (GO:0001916)2.69214262
151leukocyte migration involved in inflammatory response (GO:0002523)2.68977989
152positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.68720457
153respiratory burst (GO:0045730)2.66786176
154positive regulation of interleukin-1 beta production (GO:0032731)2.66467517
155regulation of prostaglandin secretion (GO:0032306)2.65640782
156negative regulation of necroptotic process (GO:0060546)2.64190594
157chronic inflammatory response (GO:0002544)2.64084224
158regulation of mast cell activation (GO:0033003)2.63965372
159dendritic cell migration (GO:0036336)2.63326491
160defense response to fungus (GO:0050832)2.61750602
161T-helper 1 type immune response (GO:0042088)2.61481215
162adhesion of symbiont to host (GO:0044406)2.61307611
163regulation of cholesterol esterification (GO:0010872)2.59081613
164maintenance of gastrointestinal epithelium (GO:0030277)2.58344883
165positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.57480164
166bile acid and bile salt transport (GO:0015721)2.55172209
167peptide hormone processing (GO:0016486)2.54955395
168positive regulation of mast cell degranulation (GO:0043306)2.54911906
169positive regulation of mast cell activation involved in immune response (GO:0033008)2.54911906
170ceramide catabolic process (GO:0046514)2.54794257
171cytidine catabolic process (GO:0006216)2.52583505
172cytidine deamination (GO:0009972)2.52583505
173cytidine metabolic process (GO:0046087)2.52583505

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human4.86460699
2IRF8_21731497_ChIP-ChIP_J774_Mouse3.57692550
3IRF8_22096565_ChIP-ChIP_GC-B_Human3.18516684
4SMAD_19615063_ChIP-ChIP_OVARY_Human2.78542825
5MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.78344053
6IRF8_27001747_Chip-Seq_BMDM_Mouse2.50124571
7IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.45965069
8* VDR_24763502_ChIP-Seq_THP-1_Human2.38427095
9MYB_21317192_ChIP-Seq_ERMYB_Mouse2.32438619
10Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.29744777
11PCGF2_27294783_Chip-Seq_ESCs_Mouse2.22510768
12NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.14352106
13* VDR_21846776_ChIP-Seq_THP-1_Human2.07847454
14SPI1_23127762_ChIP-Seq_K562_Human2.06886452
15CDX2_19796622_ChIP-Seq_MESCs_Mouse2.05425507
16TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.04852053
17SPI1_23547873_ChIP-Seq_NB4_Human2.01768496
18TP63_17297297_ChIP-ChIP_HaCaT_Human1.94749354
19RUNX_20019798_ChIP-Seq_JUKART_Human1.94702305
20FLI1_27457419_Chip-Seq_LIVER_Mouse1.93763429
21VDR_22108803_ChIP-Seq_LS180_Human1.87461741
22SCL_19346495_ChIP-Seq_HPC-7_Human1.84155363
23ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.83171023
24RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.81263422
25RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.75190514
26* CDX2_20551321_ChIP-Seq_CACO-2_Human1.74641529
27GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.71660140
28MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.69533295
29MYB_26560356_Chip-Seq_TH2_Human1.68763877
30RUNX1_22412390_ChIP-Seq_EML_Mouse1.68741405
31EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.68058810
32SUZ12_27294783_Chip-Seq_NPCs_Mouse1.68011351
33BRD4_27068464_Chip-Seq_AML-cells_Mouse1.67711520
34TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.67682306
35STAT4_19710469_ChIP-ChIP_TH1__Mouse1.66220386
36E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.66017116
37SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.65723143
38NFE2_27457419_Chip-Seq_LIVER_Mouse1.64322475
39TRIM28_21343339_ChIP-Seq_HEK293_Human1.60933478
40* VDR_24787735_ChIP-Seq_THP-1_Human1.55751221
41KAP1_22055183_ChIP-Seq_ESCs_Mouse1.55711609
42FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.51804178
43PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.51163355
44RXR_22158963_ChIP-Seq_LIVER_Mouse1.48838012
45MAF_26560356_Chip-Seq_TH1_Human1.48805195
46PPARA_22158963_ChIP-Seq_LIVER_Mouse1.48434599
47LXR_22158963_ChIP-Seq_LIVER_Mouse1.48110377
48SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.46502606
49EZH2_27294783_Chip-Seq_NPCs_Mouse1.46230189
50MYB_26560356_Chip-Seq_TH1_Human1.45166248
51PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.44538364
52STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.43918423
53IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.41840539
54UTX_26944678_Chip-Seq_JUKART_Human1.40957511
55TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.40018797
56LXR_22292898_ChIP-Seq_THP-1_Human1.39874235
57CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.39715201
58SOX2_27498859_Chip-Seq_STOMACH_Mouse1.39690819
59GATA1_19941827_ChIP-Seq_MEL_Mouse1.39588076
60* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.38347892
61GATA1_19941826_ChIP-Seq_K562_Human1.38098276
62FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.37760686
63NANOG_18555785_Chip-Seq_ESCs_Mouse1.36403139
64GATA2_22383799_ChIP-Seq_G1ME_Mouse1.36005040
65* STAT1_17558387_ChIP-Seq_HELA_Human1.35546174
66PCGF2_27294783_Chip-Seq_NPCs_Mouse1.31420575
67LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.31407544
68GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.30807634
69TCF7_22412390_ChIP-Seq_EML_Mouse1.30803315
70GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.30281450
71STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.30033526
72P53_22387025_ChIP-Seq_ESCs_Mouse1.29508713
73* TCF4_18268006_ChIP-ChIP_LS174T_Human1.29187337
74GATA2_19941826_ChIP-Seq_K562_Human1.28501746
75KDM2B_26808549_Chip-Seq_SUP-B15_Human1.27640219
76IKZF1_21737484_ChIP-ChIP_HCT116_Human1.27408210
77THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.25242811
78OCT4_18555785_Chip-Seq_ESCs_Mouse1.24602050
79GATA4_25053715_ChIP-Seq_YYC3_Human1.24499575
80EGR1_23403033_ChIP-Seq_LIVER_Mouse1.23242786
81OCT4_21477851_ChIP-Seq_ESCs_Mouse1.20492092
82CRX_20693478_ChIP-Seq_RETINA_Mouse1.19671571
83NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.19043454
84GATA3_27048872_Chip-Seq_THYMUS_Human1.19008841
85GATA2_21666600_ChIP-Seq_HMVEC_Human1.18781989
86EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.18517522
87STAT3_18555785_Chip-Seq_ESCs_Mouse1.18286702
88PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.18282116
89SUZ12_18555785_Chip-Seq_ESCs_Mouse1.18117926
90CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.17723274
91CMYC_18555785_Chip-Seq_ESCs_Mouse1.17543254
92BCL6_27268052_Chip-Seq_Bcells_Human1.17460877
93PU1_27457419_Chip-Seq_LIVER_Mouse1.16750960
94KDM2B_26808549_Chip-Seq_REH_Human1.16081224
95E2F1_18555785_Chip-Seq_ESCs_Mouse1.15105376
96NMYC_18555785_Chip-Seq_ESCs_Mouse1.14731189
97MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.14619871
98GATA1_22383799_ChIP-Seq_G1ME_Mouse1.14454351
99GATA1_22025678_ChIP-Seq_K562_Human1.13547496
100STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.13265169
101BCOR_27268052_Chip-Seq_Bcells_Human1.12147207
102FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.11912332
103SOX2_18555785_Chip-Seq_ESCs_Mouse1.11747307
104CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.11663161
105TAL1_26923725_Chip-Seq_HPCs_Mouse1.11087646
106ESRRB_18555785_Chip-Seq_ESCs_Mouse1.11026435
107GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.10765451
108* TP53_18474530_ChIP-ChIP_U2OS_Human1.09921546
109TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.09487610
110CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.09290683
111* CJUN_26792858_Chip-Seq_BT549_Human1.08452007
112P300_18555785_Chip-Seq_ESCs_Mouse1.08257731
113NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.07423474
114JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.06948688
115FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.06818010
116SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.06024161
117EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.05332654
118KLF4_18555785_Chip-Seq_ESCs_Mouse1.05186862
119CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.04323196
120HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.03711616
121PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.03377091
122SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.03053789
123TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.02615426
124BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.02350923
125AHR_22903824_ChIP-Seq_MCF-7_Human1.01479873
126CBX2_27304074_Chip-Seq_ESCs_Mouse1.01193985
127FOXO3_23340844_ChIP-Seq_DLD1_Human1.01126504
128GATA6_25053715_ChIP-Seq_YYC3_Human1.01026422
129GATA3_26560356_Chip-Seq_TH2_Human1.00976201
130CTCF_18555785_Chip-Seq_ESCs_Mouse1.00743113
131SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99886387
132KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.99700464
133KDM2B_26808549_Chip-Seq_DND41_Human0.99449671
134ZFX_18555785_Chip-Seq_ESCs_Mouse0.97621823
135SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.96535412
136KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.96344406
137ELK3_25401928_ChIP-Seq_HUVEC_Human0.95238928
138CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.94394438
139FOXM1_26456572_ChIP-Seq_MCF-7_Human0.94139753
140SMAD1_18555785_Chip-Seq_ESCs_Mouse0.93027366
141RUNX1_27457419_Chip-Seq_LIVER_Mouse0.93004945
142SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.92929244
143LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.92913635
144ZNF217_24962896_ChIP-Seq_MCF-7_Human0.91027290
145EGR1_19374776_ChIP-ChIP_THP-1_Human0.90454794
146* VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.90062634
147ER_23166858_ChIP-Seq_MCF-7_Human0.89749271
148VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.88935754
149KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.88651601
150SOX2_20726797_ChIP-Seq_SW620_Human0.88606080
151PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.88521297
152BMI1_23680149_ChIP-Seq_NPCS_Mouse0.88331790
153CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.88303256
154NFYB_21822215_ChIP-Seq_K562_Human0.87874861
155STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.87770978
156MAF_26560356_Chip-Seq_TH2_Human0.87574798
157ARNT_22903824_ChIP-Seq_MCF-7_Human0.87558357
158PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.86965902
159ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.85929741
160P300_19829295_ChIP-Seq_ESCs_Human0.85209283
161SUZ12_27294783_Chip-Seq_ESCs_Mouse0.84949502
162MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.84761813
163TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.82824332
164GF1_26923725_Chip-Seq_HPCs_Mouse0.82698827
165PU_27001747_Chip-Seq_BMDM_Mouse0.82424553
166HNFA_21074721_ChIP-Seq_CACO-2_Human0.81968091
167SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.81866732
168AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.81695277
169PHF8_20622853_ChIP-Seq_HELA_Human0.81423276
170JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.81326235
171CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.80995555

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002254_reproductive_system_inflammat6.51711219
2MP0005360_urolithiasis5.75114114
3MP0005410_abnormal_fertilization4.68060744
4MP0001835_abnormal_antigen_presentation4.25191288
5MP0003183_abnormal_peptide_metabolism3.68877025
6MP0009840_abnormal_foam_cell3.62192671
7MP0002876_abnormal_thyroid_physiology3.57705342
8MP0000685_abnormal_immune_system3.36631661
9MP0009785_altered_susceptibility_to3.10113667
10MP0001346_abnormal_lacrimal_gland2.99081013
11MP0004510_myositis2.94301518
12MP0005085_abnormal_gallbladder_physiolo2.94039748
13MP0002148_abnormal_hypersensitivity_rea2.82954327
14MP0006082_CNS_inflammation2.62257594
15MP0001666_abnormal_nutrient_absorption2.55697002
16MP0005365_abnormal_bile_salt2.43380857
17MP0003191_abnormal_cellular_cholesterol2.35963136
18MP0005670_abnormal_white_adipose2.30616732
19MP0004264_abnormal_extraembryonic_tissu2.25877952
20MP0004019_abnormal_vitamin_homeostasis2.25874860
21MP0002419_abnormal_innate_immunity2.21297025
22MP0008260_abnormal_autophagy2.17074219
23MP0005025_abnormal_response_to2.16642565
24MP0005310_abnormal_salivary_gland2.14236427
25MP0003436_decreased_susceptibility_to2.12926037
26MP0005000_abnormal_immune_tolerance2.04321358
27MP0000579_abnormal_nail_morphology2.01483998
28MP0001790_abnormal_immune_system2.00654977
29MP0005387_immune_system_phenotype2.00654977
30MP0004782_abnormal_surfactant_physiolog1.95372995
31MP0003300_gastrointestinal_ulcer1.92758232
32MP0003724_increased_susceptibility_to1.92026694
33MP0002139_abnormal_hepatobiliary_system1.90453679
34MP0003866_abnormal_defecation1.89694217
35MP0002277_abnormal_respiratory_mucosa1.85753654
36MP0001881_abnormal_mammary_gland1.85574617
37MP0005671_abnormal_response_to1.84488607
38MP0008057_abnormal_DNA_replication1.65635516
39MP0005058_abnormal_lysosome_morphology1.65537058
40MP0002452_abnormal_antigen_presenting1.65344574
41MP0002723_abnormal_immune_serum1.64944857
42MP0004147_increased_porphyrin_level1.61709734
43MP0005645_abnormal_hypothalamus_physiol1.60640709
44MP0001853_heart_inflammation1.59449287
45MP0001348_abnormal_lacrimal_gland1.59171306
46MP0005451_abnormal_body_composition1.59079034
47MP0000465_gastrointestinal_hemorrhage1.56885039
48MP0005503_abnormal_tendon_morphology1.56487783
49MP0003136_yellow_coat_color1.56415288
50MP0002396_abnormal_hematopoietic_system1.56346027
51MP0010155_abnormal_intestine_physiology1.49451183
52MP0010329_abnormal_lipoprotein_level1.43055206
53MP0001800_abnormal_humoral_immune1.41986769
54MP0003806_abnormal_nucleotide_metabolis1.41353439
55MP0005409_darkened_coat_color1.41119470
56MP0003448_altered_tumor_morphology1.39141730
57MP0003698_abnormal_male_reproductive1.36796020
58MP0002405_respiratory_system_inflammati1.36225004
59MP0001819_abnormal_immune_cell1.35691116
60MP0002998_abnormal_bone_remodeling1.34996213
61MP0005647_abnormal_sex_gland1.34758345
62MP0001845_abnormal_inflammatory_respons1.34634560
63MP0009764_decreased_sensitivity_to1.31085282
64MP0004947_skin_inflammation1.30405988
65MP0002420_abnormal_adaptive_immunity1.30281958
66MP0001929_abnormal_gametogenesis1.28477467
67MP0003172_abnormal_lysosome_physiology1.28399691
68MP0009379_abnormal_foot_pigmentation1.28279714
69MP0000627_abnormal_mammary_gland1.26319620
70MP0001849_ear_inflammation1.25981011
71MP0001533_abnormal_skeleton_physiology1.25604459
72MP0000490_abnormal_crypts_of1.25492946
73MP0003763_abnormal_thymus_physiology1.22225668
74MP0009643_abnormal_urine_homeostasis1.18720072
75MP0009333_abnormal_splenocyte_physiolog1.16502666
76MP0003303_peritoneal_inflammation1.13786090
77MP0002138_abnormal_hepatobiliary_system1.13379039
78MP0001664_abnormal_digestion1.12986116
79MP0002160_abnormal_reproductive_system1.12548429
80MP0001765_abnormal_ion_homeostasis1.07699990
81MP0001663_abnormal_digestive_system1.07157505
82MP0001879_abnormal_lymphatic_vessel1.06219923
83MP0002877_abnormal_melanocyte_morpholog1.05141285
84MP0002098_abnormal_vibrissa_morphology1.04385660
85MP0002295_abnormal_pulmonary_circulatio1.03545209
86MP0003252_abnormal_bile_duct1.02995775
87MP0010234_abnormal_vibrissa_follicle1.02312659
88MP0000604_amyloidosis1.01253826
89MP0009278_abnormal_bone_marrow1.01205520
90MP0003941_abnormal_skin_development1.00829341
91MP0002166_altered_tumor_susceptibility1.00536315
92MP0001873_stomach_inflammation1.00241102
93MP0005464_abnormal_platelet_physiology1.00080245
94MP0001542_abnormal_bone_strength0.98335917
95MP0002132_abnormal_respiratory_system0.96178947
96MP0005377_hearing/vestibular/ear_phenot0.95598719
97MP0003878_abnormal_ear_physiology0.95598719
98MP0008004_abnormal_stomach_pH0.95547802
99MP0008469_abnormal_protein_level0.94433253
100MP0001764_abnormal_homeostasis0.93780973
101MP0002118_abnormal_lipid_homeostasis0.93469257
102MP0002429_abnormal_blood_cell0.92759755
103MP0009697_abnormal_copulation0.91730903
104MP0005167_abnormal_blood-brain_barrier0.91284798
105MP0000716_abnormal_immune_system0.91158016
106MP0005535_abnormal_body_temperature0.90763158
107MP0003075_altered_response_to0.90408245
108MP0005275_abnormal_skin_tensile0.90277701
109MP0000566_synostosis0.89470999
110MP0002136_abnormal_kidney_physiology0.89240325
111MP0000689_abnormal_spleen_morphology0.88792874
112MP0003828_pulmonary_edema0.88329472
113MP0002006_tumorigenesis0.88327096
114MP0005332_abnormal_amino_acid0.88259118
115MP0002722_abnormal_immune_system0.87677168
116MP0000609_abnormal_liver_physiology0.86370433
117MP0000343_altered_response_to0.85854002
118MP0000249_abnormal_blood_vessel0.85700234
119MP0003868_abnormal_feces_composition0.84624849
120MP0004883_abnormal_blood_vessel0.82609786
121MP0000858_altered_metastatic_potential0.80808271
122MP0002060_abnormal_skin_morphology0.79353557
123MP0005171_absent_coat_pigmentation0.78948933
124MP0005584_abnormal_enzyme/coenzyme_acti0.78168694
125MP0005319_abnormal_enzyme/_coenzyme0.77284828
126MP0010352_gastrointestinal_tract_polyps0.76400467
127MP0001501_abnormal_sleep_pattern0.75876741
128MP0009763_increased_sensitivity_to0.75049047
129MP0003453_abnormal_keratinocyte_physiol0.74549020
130MP0005164_abnormal_response_to0.74168782
131MP0005390_skeleton_phenotype0.74063655
132MP0010386_abnormal_urinary_bladder0.73731181
133MP0005636_abnormal_mineral_homeostasis0.73398144
134MP0005448_abnormal_energy_balance0.73211953
135MP0000383_abnormal_hair_follicle0.72713359
136MP0001851_eye_inflammation0.72429265
137MP0001216_abnormal_epidermal_layer0.72139045
138MP0003879_abnormal_hair_cell0.71927787
139MP0000015_abnormal_ear_pigmentation0.71641656
140MP0005166_decreased_susceptibility_to0.71231352
141MP0000678_abnormal_parathyroid_gland0.70806795
142MP0002693_abnormal_pancreas_physiology0.70197002
143MP0002210_abnormal_sex_determination0.69539037
144MP0000767_abnormal_smooth_muscle0.68544041
145MP0001191_abnormal_skin_condition0.67631718
146MP0002398_abnormal_bone_marrow0.66904527
147MP0008995_early_reproductive_senescence0.66624867
148MP0003795_abnormal_bone_structure0.65876575
149MP0002796_impaired_skin_barrier0.65539959
150MP0008877_abnormal_DNA_methylation0.64520915
151MP0000470_abnormal_stomach_morphology0.63474559
152MP0005397_hematopoietic_system_phenotyp0.63098991
153MP0001545_abnormal_hematopoietic_system0.63098991
154MP0002161_abnormal_fertility/fecundity0.61700050

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)6.88185999
2Eczematoid dermatitis (HP:0000976)5.72390448
3Retrobulbar optic neuritis (HP:0100654)5.64291314
4Optic neuritis (HP:0100653)5.64291314
5Malnutrition (HP:0004395)5.47831688
6Dynein arm defect of respiratory motile cilia (HP:0012255)5.38341432
7Absent/shortened dynein arms (HP:0200106)5.38341432
8Orchitis (HP:0100796)5.05415788
9Keratoconjunctivitis (HP:0001096)4.72361979
10Myositis (HP:0100614)4.68625806
11Recurrent abscess formation (HP:0002722)4.57869461
12Abnormal respiratory motile cilium physiology (HP:0012261)4.32637155
13Chronic diarrhea (HP:0002028)4.01173581
14Recurrent bacterial skin infections (HP:0005406)3.98719555
15Rhinitis (HP:0012384)3.93543361
16Right ventricular cardiomyopathy (HP:0011663)3.81493927
17Keratoconjunctivitis sicca (HP:0001097)3.75902966
18Recurrent gram-negative bacterial infections (HP:0005420)3.75360799
19Hypobetalipoproteinemia (HP:0003563)3.70201301
20Mediastinal lymphadenopathy (HP:0100721)3.67301622
21Abnormal respiratory epithelium morphology (HP:0012253)3.64520689
22Abnormal respiratory motile cilium morphology (HP:0005938)3.64520689
23Systemic lupus erythematosus (HP:0002725)3.61790904
24Prostate neoplasm (HP:0100787)3.51635388
25Amyloidosis (HP:0011034)3.47616842
26Abnormal ciliary motility (HP:0012262)3.31461889
27Chronic bronchitis (HP:0004469)3.21330853
28Widely patent fontanelles and sutures (HP:0004492)3.20888732
29Abnormality of macrophages (HP:0004311)3.13926217
30Elevated erythrocyte sedimentation rate (HP:0003565)3.09249529
31Gastrointestinal infarctions (HP:0005244)3.03958559
32Acanthocytosis (HP:0001927)3.00026510
33Thick nail (HP:0001805)2.93681612
34Spontaneous hematomas (HP:0007420)2.93059647
35Pulmonary infiltrates (HP:0002113)2.91641793
36Pustule (HP:0200039)2.87498323
37Vasculitis (HP:0002633)2.83527079
38Abnormal delayed hypersensitivity skin test (HP:0002963)2.82704443
39Upper limb muscle weakness (HP:0003484)2.81831283
40Abnormality of the vitamin B12 metabolism (HP:0004341)2.78977358
41Nasal polyposis (HP:0100582)2.72177289
42Arterial thrombosis (HP:0004420)2.71037357
43Xerostomia (HP:0000217)2.70926831
44Gingivitis (HP:0000230)2.67920040
45Fat malabsorption (HP:0002630)2.66006310
46Chromosomal breakage induced by crosslinking agents (HP:0003221)2.61936803
47Nausea (HP:0002018)2.61683053
48Obstructive lung disease (HP:0006536)2.59903003
49Chronic obstructive pulmonary disease (HP:0006510)2.59903003
50Abnormality of vitamin B metabolism (HP:0004340)2.57101537
51Ileus (HP:0002595)2.54000297
52Pigmentary retinal degeneration (HP:0001146)2.53700417
53Thin bony cortex (HP:0002753)2.52954710
54Bronchiectasis (HP:0002110)2.51303854
55Recurrent skin infections (HP:0001581)2.50833585
56Hydroxyprolinuria (HP:0003080)2.50097388
57Abnormality of proline metabolism (HP:0010907)2.50097388
58Gingival bleeding (HP:0000225)2.48619701
59Chest pain (HP:0100749)2.48195446
60Recurrent fungal infections (HP:0002841)2.44306257
61Chromsome breakage (HP:0040012)2.41962710
62Amelogenesis imperfecta (HP:0000705)2.38067650
63Infertility (HP:0000789)2.37525451
64Prolonged bleeding time (HP:0003010)2.37496298
65Chronic mucocutaneous candidiasis (HP:0002728)2.35655584
66Recurrent cutaneous fungal infections (HP:0011370)2.35655584
67Inflammation of the large intestine (HP:0002037)2.34651849
68Plantar hyperkeratosis (HP:0007556)2.34364668
69Autoimmune thrombocytopenia (HP:0001973)2.32472812
70Recurrent sinusitis (HP:0011108)2.30939206
71Abnormality of the nasal mucosa (HP:0000433)2.24335458
72Onycholysis (HP:0001806)2.24306589
73Cellulitis (HP:0100658)2.23437636
74Epistaxis (HP:0000421)2.23311578
75Gastrointestinal inflammation (HP:0004386)2.21887630
76Keratitis (HP:0000491)2.21392566
77Abnormality of liposaccharide metabolism (HP:0010968)2.20916536
78Abnormality of glycosphingolipid metabolism (HP:0004343)2.20916536
79Abnormality of glycolipid metabolism (HP:0010969)2.20916536
80Hypophosphatemia (HP:0002148)2.19905091
81Loss of speech (HP:0002371)2.18375934
82Osteomyelitis (HP:0002754)2.18036809
83Confusion (HP:0001289)2.17735009
84Episodic fever (HP:0001954)2.17665965
85Increased cerebral lipofuscin (HP:0011813)2.17467009
86Hypoplasia of dental enamel (HP:0006297)2.17370661
87Aplasia cutis congenita (HP:0001057)2.16218175
88Tetraparesis (HP:0002273)2.15221993
89Abnormality of the pericardium (HP:0001697)2.14910656
90Lip pit (HP:0100267)2.14019134
91Hyperphosphatemia (HP:0002905)2.10731867
92Meningitis (HP:0001287)2.09258949
93Skin rash (HP:0000988)2.09233642
94Vacuolated lymphocytes (HP:0001922)2.08688635
95Peritonitis (HP:0002586)2.08683807
96Petechiae (HP:0000967)2.08606259
97Bronchitis (HP:0012387)2.08336649
98Increased IgM level (HP:0003496)2.08267040
99Milia (HP:0001056)2.06205861
100Leukocytosis (HP:0001974)2.05073288
101Wide cranial sutures (HP:0010537)2.03788845
102Interstitial pulmonary disease (HP:0006530)2.03471358
103Dysostosis multiplex (HP:0000943)2.02396882
104Recurrent pneumonia (HP:0006532)2.02095510
105Gangrene (HP:0100758)2.01367238
106Paresthesia (HP:0003401)1.99899686
107Fatigable weakness (HP:0003473)1.99631078
108Abnormality of the neuromuscular junction (HP:0003398)1.99631078
109Joint hemorrhage (HP:0005261)1.99455415
110Anorexia (HP:0002039)1.98981598
111Congenital sensorineural hearing impairment (HP:0008527)1.98637562
112Hemoptysis (HP:0002105)1.98612997
113Colitis (HP:0002583)1.98283606
114Abnormality of iron homeostasis (HP:0011031)1.97006147
115Disinhibition (HP:0000734)1.96946229
116Pulmonary embolism (HP:0002204)1.95804197
117Abnormality of T cell number (HP:0011839)1.95552182
118Xanthomatosis (HP:0000991)1.95462657
119Palmoplantar hyperkeratosis (HP:0000972)1.95445019
120Recurrent viral infections (HP:0004429)1.94394797
121Hemorrhage of the eye (HP:0011885)1.94071607
122Natal tooth (HP:0000695)1.93237315
123Increased serum ferritin (HP:0003281)1.92367441
124Palmar hyperkeratosis (HP:0010765)1.92142380
125Abnormality of vitamin metabolism (HP:0100508)1.91494458
126Purpura (HP:0000979)1.90376167
127T lymphocytopenia (HP:0005403)1.90228921
128Absent frontal sinuses (HP:0002688)1.89685487
129Glomerulonephritis (HP:0000099)1.89160164
130Increased neuronal autofluorescent lipopigment (HP:0002074)1.88151618
131Pancreatitis (HP:0001733)1.87918499
132Type 2 muscle fiber atrophy (HP:0003554)1.87622761
133Vascular calcification (HP:0004934)1.85506017
134Premature loss of primary teeth (HP:0006323)1.85144522
135Glomerulopathy (HP:0100820)1.83889778
136Segmental peripheral demyelination/remyelination (HP:0003481)1.83036594
137Enlarged epiphyses (HP:0010580)1.82493098
138Urticaria (HP:0001025)1.82233742
139Hypolipoproteinemia (HP:0010981)1.82111531
140Basal ganglia calcification (HP:0002135)1.81795756
141Abnormality of T cells (HP:0002843)1.81777432
142Abnormality of the costochondral junction (HP:0000919)1.80521277
143Abnormality of T cell physiology (HP:0011840)1.80453862
144Hypergammaglobulinemia (HP:0010702)1.79054249
145Bilateral sensorineural hearing impairment (HP:0008619)1.77983346
146Abnormality of the prostate (HP:0008775)1.77136781
147Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.75232726
148Eosinophilia (HP:0001880)1.73686320
149Prolonged neonatal jaundice (HP:0006579)1.72221231
150White forelock (HP:0002211)1.71462048
151Cardiovascular calcification (HP:0011915)1.69003586
152Abnormality of the nasal septum (HP:0000419)1.67158719
153Abnormality of the pleura (HP:0002103)1.65797677
154Stomatitis (HP:0010280)1.64752997
155Alopecia of scalp (HP:0002293)1.64743942
156Recurrent lower respiratory tract infections (HP:0002783)1.63909449
157Azoospermia (HP:0000027)1.63313314
158Abnormality of glutamine family amino acid metabolism (HP:0010902)1.62978133
159Increased IgE level (HP:0003212)1.62219171
160Craniofacial hyperostosis (HP:0004493)1.61082801
161Syringomyelia (HP:0003396)1.60704587
162Spinal cord lesions (HP:0100561)1.60704587
163Encephalitis (HP:0002383)1.59361967

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K144.64881996
2TESK13.93926987
3RIPK43.87355344
4ERN13.85676028
5ACVR1B3.73449646
6MAP4K12.89595782
7IRAK32.84141283
8IRAK42.77702093
9BMX2.62739660
10INSRR2.53231362
11BMPR22.53156739
12TXK2.50820979
13PDK22.34926294
14TBK12.28047738
15MAP2K32.27054924
16GRK62.26146348
17PDK42.16705514
18PDK32.16705514
19IKBKB2.15392576
20EIF2AK22.14107012
21ZAK2.11784304
22CLK12.08409706
23FES2.00507649
24PRPF4B1.89065402
25FRK1.88553213
26ZAP701.80239214
27DYRK1B1.77139705
28ERBB31.75872970
29JAK31.74461112
30CHUK1.60318767
31TESK21.60142764
32PKN11.60028337
33CSF1R1.58254262
34TGFBR21.53370180
35JAK11.51832375
36MAP3K111.47717624
37EPHA31.46686625
38PRKD31.46516075
39TAOK11.45884815
40FGR1.44931818
41IKBKE1.42640308
42PIM21.40574363
43TEC1.38873914
44STK381.38301089
45NLK1.31427762
46BRD41.29604250
47MAP2K71.27487619
48EPHB11.25431609
49EPHA21.23191428
50MAP3K21.23142936
51KIT1.20200674
52DYRK31.18205652
53IRAK11.13331111
54CDK191.12447592
55BTK1.12131206
56PNCK1.10955946
57PDK11.05836850
58PDPK11.05416048
59PIK3CG1.04667484
60TAOK31.01907336
61LCK1.01283062
62KSR21.00633573
63NUAK10.98706333
64PTK2B0.96284339
65LATS10.93630700
66CAMK1G0.93519046
67MAP3K130.91111103
68EPHB20.88836825
69JAK20.85925351
70MAP3K60.81828619
71BCR0.80481541
72OXSR10.80392746
73MARK30.79703189
74DAPK20.78837132
75CDC42BPA0.78255663
76BLK0.77378953
77PRKCD0.76096759
78GRK50.71855210
79MAP2K20.71422067
80CAMK10.71403823
81MST1R0.70459300
82FYN0.68811212
83MAP3K100.68778756
84STK100.68237085
85MAP2K60.67418820
86CSK0.65299881
87MAPK70.64484489
88TAOK20.62858639
89TYK20.62777598
90RIPK10.62729951
91ADRBK20.62667036
92PTK60.62519898
93YES10.61919228
94FER0.60229368
95DDR20.57024246
96IRAK20.55881094
97MAPK120.54832080
98GRK70.54381547
99MAP3K10.52748569
100MAP3K50.52342511
101PLK20.52086370
102MST40.50598657
103MAP3K30.49703388
104PRKAA20.48829460
105TRIB30.48351501
106PRKD20.47772172
107CAMKK20.47732221
108TRPM70.47682402
109MATK0.47669810
110MARK20.47093970
111RET0.46603996
112AKT20.45123156
113LYN0.45096979
114STK38L0.44275153
115TNK20.43698247
116STK30.43102424
117SIK30.42846759
118LRRK20.42817533
119MAP3K70.42698093
120GRK10.42324308
121PIM10.42239181
122BMPR1B0.42008847
123CDK60.41073060
124MAP3K120.40858103
125HCK0.39700272
126PRKCZ0.39341328
127RPS6KC10.38425385
128RPS6KL10.38425385
129PRKCQ0.38179019
130PRKG20.35862177
131MAPKAPK20.35461426
132PLK10.34829107
133MYLK0.34813404
134MAP2K40.34734718
135EGFR0.34062255
136CAMK2G0.33570307
137PRKACG0.33312061
138STK110.32459913
139NME10.32006818
140MAPK150.31004739
141GSK3A0.30957202
142TIE10.30703478
143AURKB0.30460612
144SYK0.30339689
145IGF1R0.29724633
146ITK0.29689668
147FGFR40.27173109
148ABL10.25849090
149FGFR30.25580037
150AURKA0.24460224
151PRKCE0.23183905

Predicted pathways (KEGG)

RankGene SetZ-score
1Graft-versus-host disease_Homo sapiens_hsa053323.25272335
2NF-kappa B signaling pathway_Homo sapiens_hsa040642.89570220
3Legionellosis_Homo sapiens_hsa051342.86784737
4Cyanoamino acid metabolism_Homo sapiens_hsa004602.84839075
5Leishmaniasis_Homo sapiens_hsa051402.76804978
6Asthma_Homo sapiens_hsa053102.57290013
7Allograft rejection_Homo sapiens_hsa053302.48454467
8Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.34328399
9NOD-like receptor signaling pathway_Homo sapiens_hsa046212.33844140
10TNF signaling pathway_Homo sapiens_hsa046682.27245791
11Rheumatoid arthritis_Homo sapiens_hsa053232.21885387
12African trypanosomiasis_Homo sapiens_hsa051432.18588721
13Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.10312330
14Intestinal immune network for IgA production_Homo sapiens_hsa046722.08579088
15Toll-like receptor signaling pathway_Homo sapiens_hsa046201.99136431
16Osteoclast differentiation_Homo sapiens_hsa043801.94310910
17Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.92062196
18Malaria_Homo sapiens_hsa051441.86831107
19Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.85148979
20Galactose metabolism_Homo sapiens_hsa000521.80348065
21Autoimmune thyroid disease_Homo sapiens_hsa053201.80082929
22Staphylococcus aureus infection_Homo sapiens_hsa051501.73011729
23Measles_Homo sapiens_hsa051621.72764805
24RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.71695542
25Histidine metabolism_Homo sapiens_hsa003401.67223158
26Type I diabetes mellitus_Homo sapiens_hsa049401.66656366
27* Arachidonic acid metabolism_Homo sapiens_hsa005901.62213711
28Tuberculosis_Homo sapiens_hsa051521.59792848
29Pertussis_Homo sapiens_hsa051331.59524886
30Hematopoietic cell lineage_Homo sapiens_hsa046401.55424610
31Other glycan degradation_Homo sapiens_hsa005111.48160066
32Influenza A_Homo sapiens_hsa051641.43205768
33Toxoplasmosis_Homo sapiens_hsa051451.39630650
34Drug metabolism - other enzymes_Homo sapiens_hsa009831.35935709
35Salmonella infection_Homo sapiens_hsa051321.33206734
36Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.24374474
37Phagosome_Homo sapiens_hsa041451.23291023
38Fructose and mannose metabolism_Homo sapiens_hsa000511.22298295
39Apoptosis_Homo sapiens_hsa042101.19116291
40Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.18974066
41Jak-STAT signaling pathway_Homo sapiens_hsa046301.18609832
42Glycosaminoglycan degradation_Homo sapiens_hsa005311.18541322
43Antigen processing and presentation_Homo sapiens_hsa046121.16499584
44Amoebiasis_Homo sapiens_hsa051461.14500657
45Pentose and glucuronate interconversions_Homo sapiens_hsa000401.13276960
46Chemical carcinogenesis_Homo sapiens_hsa052041.12939536
47Herpes simplex infection_Homo sapiens_hsa051681.05370465
48AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.05135691
49Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.01994215
50Chemokine signaling pathway_Homo sapiens_hsa040621.01432158
51* alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.00516761
52* Linoleic acid metabolism_Homo sapiens_hsa005910.99833994
53Leukocyte transendothelial migration_Homo sapiens_hsa046700.98998375
54Bile secretion_Homo sapiens_hsa049760.98828157
55Adherens junction_Homo sapiens_hsa045200.96140324
56Fatty acid biosynthesis_Homo sapiens_hsa000610.95617160
57Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.93848822
58Retinol metabolism_Homo sapiens_hsa008300.91372303
59Glycerolipid metabolism_Homo sapiens_hsa005610.90111333
60Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.88643216
61Phenylalanine metabolism_Homo sapiens_hsa003600.88330512
62Primary immunodeficiency_Homo sapiens_hsa053400.87784885
63Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.87489725
64Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.87261133
65Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.86649990
66Small cell lung cancer_Homo sapiens_hsa052220.82741500
67Sphingolipid metabolism_Homo sapiens_hsa006000.76851739
68Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.75688302
69Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.75019170
70Steroid hormone biosynthesis_Homo sapiens_hsa001400.74133367
71Mineral absorption_Homo sapiens_hsa049780.71727619
72Transcriptional misregulation in cancer_Homo sapiens_hsa052020.71633094
73Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.68774910
74Platelet activation_Homo sapiens_hsa046110.68542041
75* Ether lipid metabolism_Homo sapiens_hsa005650.68513143
76Viral myocarditis_Homo sapiens_hsa054160.68510837
77Hepatitis C_Homo sapiens_hsa051600.68426744
78Arginine biosynthesis_Homo sapiens_hsa002200.68377586
79Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.66866530
80Renin-angiotensin system_Homo sapiens_hsa046140.65235233
81Adipocytokine signaling pathway_Homo sapiens_hsa049200.64906362
82* Glycerophospholipid metabolism_Homo sapiens_hsa005640.61234425
83Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.60975882
84Hepatitis B_Homo sapiens_hsa051610.60855525
85Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.59273357
86Prolactin signaling pathway_Homo sapiens_hsa049170.57524428
87Carbohydrate digestion and absorption_Homo sapiens_hsa049730.57368267
88Fat digestion and absorption_Homo sapiens_hsa049750.56188468
89Insulin resistance_Homo sapiens_hsa049310.54921965
90Lysosome_Homo sapiens_hsa041420.53474970
91Shigellosis_Homo sapiens_hsa051310.53060433
92B cell receptor signaling pathway_Homo sapiens_hsa046620.52155735
93GnRH signaling pathway_Homo sapiens_hsa049120.52010494
94Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.47113346
95Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.46916751
96Collecting duct acid secretion_Homo sapiens_hsa049660.45497217
97* Vitamin digestion and absorption_Homo sapiens_hsa049770.44892664
98Complement and coagulation cascades_Homo sapiens_hsa046100.44076446
99ABC transporters_Homo sapiens_hsa020100.43532822
100ECM-receptor interaction_Homo sapiens_hsa045120.43227650
101Protein digestion and absorption_Homo sapiens_hsa049740.41049821
102Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.40771713
103Tight junction_Homo sapiens_hsa045300.38245134
104Phosphatidylinositol signaling system_Homo sapiens_hsa040700.37705128
105Dorso-ventral axis formation_Homo sapiens_hsa043200.37450118
106Pancreatic secretion_Homo sapiens_hsa049720.36917197
107Sphingolipid signaling pathway_Homo sapiens_hsa040710.36471167
108Tryptophan metabolism_Homo sapiens_hsa003800.36143852
109Pentose phosphate pathway_Homo sapiens_hsa000300.35498737
110T cell receptor signaling pathway_Homo sapiens_hsa046600.35488184
111Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.35111473
112Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.34210299
113Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.33940677
114Acute myeloid leukemia_Homo sapiens_hsa052210.33665388
115Epstein-Barr virus infection_Homo sapiens_hsa051690.33254396
116HTLV-I infection_Homo sapiens_hsa051660.33077466
117Regulation of actin cytoskeleton_Homo sapiens_hsa048100.32525330
118Maturity onset diabetes of the young_Homo sapiens_hsa049500.32247809
119Rap1 signaling pathway_Homo sapiens_hsa040150.32193126
120Melanoma_Homo sapiens_hsa052180.31353688
121beta-Alanine metabolism_Homo sapiens_hsa004100.31091744
122Renin secretion_Homo sapiens_hsa049240.29898304
123Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.28996222
124Sulfur metabolism_Homo sapiens_hsa009200.26440974
125PPAR signaling pathway_Homo sapiens_hsa033200.26432476
126Viral carcinogenesis_Homo sapiens_hsa052030.26087223
127Pathways in cancer_Homo sapiens_hsa052000.26047044
128Caffeine metabolism_Homo sapiens_hsa002320.25737783
129p53 signaling pathway_Homo sapiens_hsa041150.24827879
130Starch and sucrose metabolism_Homo sapiens_hsa005000.24035507
131Type II diabetes mellitus_Homo sapiens_hsa049300.22221358
132Focal adhesion_Homo sapiens_hsa045100.19236872

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