PLBD1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.63902262
2positive regulation of gamma-delta T cell activation (GO:0046645)5.54505159
3negative regulation of cell killing (GO:0031342)5.48511419
4negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.48511419
5positive regulation by organism of defense response of other organism involved in symbiotic interact4.82787412
6modulation by symbiont of host immune response (GO:0052553)4.82787412
7positive regulation by symbiont of host defense response (GO:0052509)4.82787412
8modulation by symbiont of host defense response (GO:0052031)4.82787412
9modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.82787412
10modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.82787412
11detection of molecule of bacterial origin (GO:0032490)4.79560848
12negative regulation of interleukin-12 production (GO:0032695)4.74248789
13detection of biotic stimulus (GO:0009595)4.39255336
14positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.37759245
15regulation of B cell receptor signaling pathway (GO:0050855)4.37442936
16leukocyte migration involved in inflammatory response (GO:0002523)4.32766716
17antigen processing and presentation of endogenous antigen (GO:0019883)4.25022786
18cellular extravasation (GO:0045123)4.24702504
19production of molecular mediator involved in inflammatory response (GO:0002532)4.23290834
20response to peptidoglycan (GO:0032494)4.08368309
21respiratory burst (GO:0045730)4.06536225
22regulation of dendritic cell antigen processing and presentation (GO:0002604)4.01872564
23macrophage activation (GO:0042116)3.97460523
24regulation of gamma-delta T cell activation (GO:0046643)3.96521140
25myeloid cell activation involved in immune response (GO:0002275)3.88507455
26immunoglobulin mediated immune response (GO:0016064)3.84104211
27neutrophil activation involved in immune response (GO:0002283)3.80397008
28negative regulation of lymphocyte mediated immunity (GO:0002707)3.79319204
29regulation of mast cell activation involved in immune response (GO:0033006)3.78589940
30neutrophil mediated immunity (GO:0002446)3.70884091
31killing of cells in other organism involved in symbiotic interaction (GO:0051883)3.67877128
32disruption of cells of other organism involved in symbiotic interaction (GO:0051818)3.67877128
33regulation of interferon-beta biosynthetic process (GO:0045357)3.66209662
34indolalkylamine catabolic process (GO:0046218)3.61607154
35tryptophan catabolic process (GO:0006569)3.61607154
36indole-containing compound catabolic process (GO:0042436)3.61607154
37response to host immune response (GO:0052572)3.61399044
38response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.61399044
39leukocyte aggregation (GO:0070486)3.60574772
40antigen processing and presentation via MHC class Ib (GO:0002475)3.53204693
41positive regulation of antigen processing and presentation (GO:0002579)3.46950222
42fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.46207315
43response to muramyl dipeptide (GO:0032495)3.45649846
44detection of bacterium (GO:0016045)3.43727535
45positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.42746521
46positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.41944200
47cellular response to exogenous dsRNA (GO:0071360)3.40999146
48kynurenine metabolic process (GO:0070189)3.38273985
49negative regulation of leukocyte mediated immunity (GO:0002704)3.37946509
50triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.37493591
51negative regulation of T cell mediated immunity (GO:0002710)3.36353523
52detection of other organism (GO:0098543)3.35810896
53microglial cell activation (GO:0001774)3.32340344
54macrophage activation involved in immune response (GO:0002281)3.30402124
55regulation of triglyceride catabolic process (GO:0010896)3.30114398
56pinocytosis (GO:0006907)3.29660074
57aromatic amino acid family catabolic process (GO:0009074)3.29182379
58complement activation, alternative pathway (GO:0006957)3.28852080
59positive regulation of monocyte chemotaxis (GO:0090026)3.28571051
60positive regulation of mast cell activation (GO:0033005)3.27462682
61regulation of tolerance induction (GO:0002643)3.26489025
62regulation of phospholipase A2 activity (GO:0032429)3.25752034
63tryptophan metabolic process (GO:0006568)3.25545519
64alpha-linolenic acid metabolic process (GO:0036109)3.24976688
65regulation of gamma-delta T cell differentiation (GO:0045586)3.23814885
66interferon-gamma-mediated signaling pathway (GO:0060333)3.23735794
67hydrogen peroxide biosynthetic process (GO:0050665)3.21846769
68response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.20741973
69response to host (GO:0075136)3.20741973
70response to host defenses (GO:0052200)3.20741973
71positive regulation of interferon-alpha production (GO:0032727)3.19343458
72negative regulation of erythrocyte differentiation (GO:0045647)3.19224138
73regulation of regulated secretory pathway (GO:1903305)3.19019232
74urea metabolic process (GO:0019627)3.18494603
75urea cycle (GO:0000050)3.18494603
76positive regulation of toll-like receptor signaling pathway (GO:0034123)3.17532655
77myeloid leukocyte mediated immunity (GO:0002444)3.16287899
78leukocyte degranulation (GO:0043299)3.16270478
79regulation of T-helper 2 cell differentiation (GO:0045628)3.14859140
80low-density lipoprotein particle clearance (GO:0034383)3.13304198
81positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.12925559
82regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.11410111
83negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.10986201
84killing of cells of other organism (GO:0031640)3.10778844
85disruption of cells of other organism (GO:0044364)3.10778844
86plasma lipoprotein particle clearance (GO:0034381)3.10403237
87regulation of T cell tolerance induction (GO:0002664)3.09460286
88intracellular pH reduction (GO:0051452)3.08186667
89phospholipid efflux (GO:0033700)3.06707137
90defense response to protozoan (GO:0042832)3.05783337
91neutrophil chemotaxis (GO:0030593)3.05316341
92positive regulation of leukocyte degranulation (GO:0043302)3.04061417
93neutrophil activation (GO:0042119)3.03948242
94type I interferon signaling pathway (GO:0060337)3.03766328
95cellular response to type I interferon (GO:0071357)3.03766328
96regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.02545114
97myeloid leukocyte activation (GO:0002274)3.01735923
98germinal center formation (GO:0002467)3.01612572
99defense response to fungus (GO:0050832)3.01109943
100Arp2/3 complex-mediated actin nucleation (GO:0034314)3.01062709
101response to type I interferon (GO:0034340)3.00019898
102negative regulation of interleukin-6 production (GO:0032715)2.99245019
103regulation of interferon-alpha production (GO:0032647)2.98107927
104neutrophil migration (GO:1990266)2.97598753
105granulocyte activation (GO:0036230)2.96096122
106positive regulation of chemokine biosynthetic process (GO:0045080)2.94304878
107antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.93608069
108antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.93608069
109positive regulation of regulated secretory pathway (GO:1903307)2.92978824
110B cell receptor signaling pathway (GO:0050853)2.91981303
111regulation of antigen processing and presentation (GO:0002577)2.91762680
112positive regulation of cellular amide metabolic process (GO:0034250)2.90803083
113regulation of interleukin-8 biosynthetic process (GO:0045414)2.90102657
114positive regulation of mast cell degranulation (GO:0043306)2.89980116
115positive regulation of mast cell activation involved in immune response (GO:0033008)2.89980116
116regulation of mast cell activation (GO:0033003)2.89392902
117nitrogen cycle metabolic process (GO:0071941)2.88756315
118negative regulation of cytokine production involved in immune response (GO:0002719)2.88335443
119positive regulation of lipid catabolic process (GO:0050996)2.88222824
120L-phenylalanine catabolic process (GO:0006559)2.88062003
121erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.88062003
122regulation of myeloid leukocyte mediated immunity (GO:0002886)2.87560423
123positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.86431598
124positive regulation of B cell differentiation (GO:0045579)2.85656229
125cell killing (GO:0001906)2.81446607
126high-density lipoprotein particle remodeling (GO:0034375)2.81115564
127response to interleukin-15 (GO:0070672)2.80657453
128regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.79348548
129detection of external biotic stimulus (GO:0098581)2.78333694
130regulation of cholesterol storage (GO:0010885)2.78177507
131reactive oxygen species biosynthetic process (GO:1903409)2.78112278
132positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.77907729
133regulation of B cell differentiation (GO:0045577)2.76129326
134regulation of mast cell degranulation (GO:0043304)2.74427285
135regulation of monocyte chemotaxis (GO:0090025)2.73576229
136protein carboxylation (GO:0018214)2.73278417
137peptidyl-glutamic acid carboxylation (GO:0017187)2.73278417
138B cell mediated immunity (GO:0019724)2.72699210
139superoxide anion generation (GO:0042554)2.70826916
140regulation of cholesterol esterification (GO:0010872)2.70488011
141regulation of protein activation cascade (GO:2000257)2.69920248
142L-phenylalanine metabolic process (GO:0006558)2.69496131
143erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.69496131
144bile acid biosynthetic process (GO:0006699)2.66303751
145lipopolysaccharide-mediated signaling pathway (GO:0031663)2.66099649
146leukocyte mediated cytotoxicity (GO:0001909)2.66026848
147negative regulation of mast cell activation (GO:0033004)2.64822617
148positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.62547625
149regulation of leukocyte degranulation (GO:0043300)2.60009113
150phospholipid homeostasis (GO:0055091)2.59701772
151response to fungus (GO:0009620)2.59289232
152regulation of complement activation (GO:0030449)2.57087261
153amino-acid betaine metabolic process (GO:0006577)2.57014800

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.39023429
2IRF8_21731497_ChIP-ChIP_J774_Mouse5.34140096
3IRF8_22096565_ChIP-ChIP_GC-B_Human4.29009285
4BP1_19119308_ChIP-ChIP_Hs578T_Human4.00571839
5RXR_22158963_ChIP-Seq_LIVER_Mouse3.97212862
6* PPARA_22158963_ChIP-Seq_LIVER_Mouse3.71029196
7IRF8_27001747_Chip-Seq_BMDM_Mouse3.57545445
8PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.43978114
9TP63_17297297_ChIP-ChIP_HaCaT_Human3.36280788
10LXR_22158963_ChIP-Seq_LIVER_Mouse3.22304449
11EGR1_23403033_ChIP-Seq_LIVER_Mouse3.20884231
12* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.02852341
13* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.70217860
14MYB_21317192_ChIP-Seq_ERMYB_Mouse2.68143052
15MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.63585590
16IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.62041735
17Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.60686711
18IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.53115298
19* CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.36424149
20NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.32271312
21STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.30650508
22FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.27513252
23* BRD4_27068464_Chip-Seq_AML-cells_Mouse2.27258165
24STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.27132379
25FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.26072693
26RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.22883401
27CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.14209129
28SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.12118648
29STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.07463925
30STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.04612065
31VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.90678514
32RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.83613454
33NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.79926718
34CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.77401823
35STAT4_19710469_ChIP-ChIP_TH1__Mouse1.68056340
36SPI1_23547873_ChIP-Seq_NB4_Human1.67483501
37TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.65701558
38EGR1_19374776_ChIP-ChIP_THP-1_Human1.62235049
39TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.62164970
40KDM2B_26808549_Chip-Seq_SUP-B15_Human1.60301255
41CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.57790915
42MYC_22102868_ChIP-Seq_BL_Human1.57526838
43PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.52440931
44SMAD_19615063_ChIP-ChIP_OVARY_Human1.44679625
45MAF_26560356_Chip-Seq_TH1_Human1.44109467
46TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.43659907
47MYB_26560356_Chip-Seq_TH2_Human1.43219074
48SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.40332287
49KDM2B_26808549_Chip-Seq_DND41_Human1.39710609
50FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.38822182
51THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.38373531
52NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.37262657
53EGR1_19032775_ChIP-ChIP_M12_Human1.35240270
54KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.34823536
55CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.33713184
56PU_27001747_Chip-Seq_BMDM_Mouse1.33026874
57LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.32637350
58GATA1_22025678_ChIP-Seq_K562_Human1.31966577
59RUNX_20019798_ChIP-Seq_JUKART_Human1.31363370
60* SPI1_23127762_ChIP-Seq_K562_Human1.27363579
61SCL_19346495_ChIP-Seq_HPC-7_Human1.22464147
62RUNX1_22412390_ChIP-Seq_EML_Mouse1.20942509
63CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.20678264
64MYB_26560356_Chip-Seq_TH1_Human1.20120607
65ELK3_25401928_ChIP-Seq_HUVEC_Human1.19626074
66VDR_24763502_ChIP-Seq_THP-1_Human1.19550853
67MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.19034823
68KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.18481285
69GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.18267286
70VDR_24787735_ChIP-Seq_THP-1_Human1.17577167
71LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.15864683
72ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.15402898
73CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.14986134
74PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.11745499
75ELF1_17652178_ChIP-ChIP_JURKAT_Human1.11741499
76RARG_19884340_ChIP-ChIP_MEFs_Mouse1.09886244
77HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.09849610
78SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.09668298
79GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.09248850
80PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.08801731
81GATA2_22383799_ChIP-Seq_G1ME_Mouse1.08391151
82SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.05739947
83GATA3_27048872_Chip-Seq_THYMUS_Human1.05048459
84E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.03556279
85PU.1_20513432_ChIP-Seq_Bcells_Mouse1.03149285
86GATA3_26560356_Chip-Seq_TH2_Human1.02728486
87FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.02598738
88P63_26484246_Chip-Seq_KERATINOCYTES_Human1.02513238
89CLOCK_20551151_ChIP-Seq_293T_Human1.02395684
90PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.01306869
91SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.00419549
92GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99774427
93* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.99171591
94VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.98770574
95FOXO3_23340844_ChIP-Seq_DLD1_Human0.98631519
96UTX_26944678_Chip-Seq_JUKART_Human0.97952762
97GATA1_19941827_ChIP-Seq_MEL_Mouse0.97349978
98SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.95897903
99BCOR_27268052_Chip-Seq_Bcells_Human0.95571791
100IKZF1_21737484_ChIP-ChIP_HCT116_Human0.93285270
101VDR_21846776_ChIP-Seq_THP-1_Human0.91788997
102NCOR1_26117541_ChIP-Seq_K562_Human0.91521257
103* TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.90306558
104GATA2_21666600_ChIP-Seq_HMVEC_Human0.90023175
105CDX2_20551321_ChIP-Seq_CACO-2_Human0.89663568
106NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.89331377
107GATA4_25053715_ChIP-Seq_YYC3_Human0.89257652
108KDM2B_26808549_Chip-Seq_JURKAT_Human0.87154730
109TCF7_22412390_ChIP-Seq_EML_Mouse0.86984561
110BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.86885908
111STAT6_21828071_ChIP-Seq_BEAS2B_Human0.86621758
112SOX2_27498859_Chip-Seq_STOMACH_Mouse0.86358973
113BCL6_27268052_Chip-Seq_Bcells_Human0.83696231
114RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.81481218
115TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.80920842
116GATA2_19941826_ChIP-Seq_K562_Human0.79980186
117SPI1_20517297_ChIP-Seq_HL60_Human0.78391190
118TFEB_21752829_ChIP-Seq_HELA_Human0.77955654
119GATA1_22383799_ChIP-Seq_G1ME_Mouse0.77328431
120MAF_26560356_Chip-Seq_TH2_Human0.76572522
121FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.75023180
122GATA1_19941827_ChIP-Seq_MEL86_Mouse0.74733262
123STAT1_20625510_ChIP-Seq_HELA_Human0.74429359
124KAP1_22055183_ChIP-Seq_ESCs_Mouse0.73986457
125KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.73820454
126LXR_22292898_ChIP-Seq_THP-1_Human0.72971708
127P300_27268052_Chip-Seq_Bcells_Human0.72054485
128GATA1_19941826_ChIP-Seq_K562_Human0.69935062

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.67070502
2MP0003436_decreased_susceptibility_to3.34094305
3MP0005360_urolithiasis3.27208133
4MP0002139_abnormal_hepatobiliary_system3.14448698
5MP0003303_peritoneal_inflammation2.75996825
6MP0009785_altered_susceptibility_to2.73396974
7MP0001853_heart_inflammation2.66707669
8MP0005085_abnormal_gallbladder_physiolo2.63009639
9MP0002419_abnormal_innate_immunity2.53219873
10MP0002148_abnormal_hypersensitivity_rea2.46341701
11MP0005365_abnormal_bile_salt2.33854909
12MP0005025_abnormal_response_to2.33745431
13MP0000685_abnormal_immune_system2.30240623
14MP0009840_abnormal_foam_cell2.27790164
15MP0003806_abnormal_nucleotide_metabolis2.14062914
16MP0005387_immune_system_phenotype2.10787034
17MP0001790_abnormal_immune_system2.10787034
18MP0002138_abnormal_hepatobiliary_system2.10699172
19MP0003172_abnormal_lysosome_physiology2.05555968
20MP0005000_abnormal_immune_tolerance2.04389557
21MP0004510_myositis2.01064348
22MP0003191_abnormal_cellular_cholesterol2.00395279
23MP0009764_decreased_sensitivity_to1.99164504
24MP0002452_abnormal_antigen_presenting1.99086861
25MP0010329_abnormal_lipoprotein_level1.96165727
26MP0003724_increased_susceptibility_to1.94243514
27MP0001800_abnormal_humoral_immune1.94033563
28MP0005451_abnormal_body_composition1.93141340
29MP0006082_CNS_inflammation1.92004613
30MP0005671_abnormal_response_to1.91554319
31MP0008875_abnormal_xenobiotic_pharmacok1.91244985
32MP0002723_abnormal_immune_serum1.70090094
33MP0003252_abnormal_bile_duct1.67191910
34MP0001819_abnormal_immune_cell1.64777348
35MP0002132_abnormal_respiratory_system1.63973445
36MP0004947_skin_inflammation1.60554201
37MP0005464_abnormal_platelet_physiology1.60140382
38MP0002420_abnormal_adaptive_immunity1.58279854
39MP0001845_abnormal_inflammatory_respons1.57000938
40MP0002796_impaired_skin_barrier1.52311774
41MP0003763_abnormal_thymus_physiology1.52103829
42MP0001666_abnormal_nutrient_absorption1.51927033
43MP0000465_gastrointestinal_hemorrhage1.48740375
44MP0002405_respiratory_system_inflammati1.48305483
45MP0000343_altered_response_to1.47484029
46MP0008469_abnormal_protein_level1.45590514
47MP0001533_abnormal_skeleton_physiology1.45510695
48MP0002166_altered_tumor_susceptibility1.43349406
49MP0002254_reproductive_system_inflammat1.43013959
50MP0000609_abnormal_liver_physiology1.42873705
51MP0010155_abnormal_intestine_physiology1.42053262
52MP0009278_abnormal_bone_marrow1.39023907
53MP0002998_abnormal_bone_remodeling1.38518196
54MP0003453_abnormal_keratinocyte_physiol1.37261063
55MP0004019_abnormal_vitamin_homeostasis1.37213585
56MP0002722_abnormal_immune_system1.36134361
57MP0002006_tumorigenesis1.31618627
58MP0003075_altered_response_to1.29534089
59MP0008004_abnormal_stomach_pH1.24532140
60MP0003690_abnormal_glial_cell1.23792326
61MP0002837_dystrophic_cardiac_calcinosis1.21363123
62MP0002118_abnormal_lipid_homeostasis1.21255469
63MP0010234_abnormal_vibrissa_follicle1.19272231
64MP0005319_abnormal_enzyme/_coenzyme1.18057237
65MP0005164_abnormal_response_to1.16550616
66MP0005058_abnormal_lysosome_morphology1.14213669
67MP0002876_abnormal_thyroid_physiology1.13186763
68MP0005332_abnormal_amino_acid1.12470413
69MP0003300_gastrointestinal_ulcer1.11104569
70MP0001764_abnormal_homeostasis1.10661313
71MP0005167_abnormal_blood-brain_barrier1.10353446
72MP0002277_abnormal_respiratory_mucosa1.10205010
73MP0005670_abnormal_white_adipose1.10137368
74MP0005397_hematopoietic_system_phenotyp1.10003407
75MP0001545_abnormal_hematopoietic_system1.10003407
76MP0003828_pulmonary_edema1.09179089
77MP0000716_abnormal_immune_system1.07358966
78MP0001216_abnormal_epidermal_layer1.05620461
79MP0009763_increased_sensitivity_to1.05069509
80MP0000703_abnormal_thymus_morphology1.03244070
81MP0005166_decreased_susceptibility_to1.02556694
82MP0009333_abnormal_splenocyte_physiolog1.00423156
83MP0003186_abnormal_redox_activity1.00232133
84MP0003656_abnormal_erythrocyte_physiolo1.00044306
85MP0003566_abnormal_cell_adhesion0.98152173
86MP0000858_altered_metastatic_potential0.97615930
87MP0003183_abnormal_peptide_metabolism0.97334474
88MP0005584_abnormal_enzyme/coenzyme_acti0.95110730
89MP0003705_abnormal_hypodermis_morpholog0.92713455
90MP0003448_altered_tumor_morphology0.89621493
91MP0010352_gastrointestinal_tract_polyps0.89607383
92MP0000604_amyloidosis0.89208666
93MP0002396_abnormal_hematopoietic_system0.89195262
94MP0002398_abnormal_bone_marrow0.89004871
95MP0004782_abnormal_surfactant_physiolog0.86928784
96MP0005390_skeleton_phenotype0.86288090
97MP0009643_abnormal_urine_homeostasis0.86040535
98MP0004381_abnormal_hair_follicle0.85963371
99MP0002429_abnormal_blood_cell0.85152665
100MP0001663_abnormal_digestive_system0.85145101
101MP0005076_abnormal_cell_differentiation0.83921325
102MP0000689_abnormal_spleen_morphology0.83626326
103MP0004883_abnormal_blood_vessel0.83132780
104MP0002060_abnormal_skin_morphology0.81187199
105MP0008260_abnormal_autophagy0.80068944
106MP0000579_abnormal_nail_morphology0.79911027
107MP0001851_eye_inflammation0.79317058
108MP0005310_abnormal_salivary_gland0.78943561
109MP0003866_abnormal_defecation0.78877450
110MP0003638_abnormal_response/metabolism_0.78275602
111MP0005666_abnormal_adipose_tissue0.77930878
112MP0000598_abnormal_liver_morphology0.76867288
113MP0005334_abnormal_fat_pad0.76264467
114MP0003011_delayed_dark_adaptation0.75716649
115MP0009765_abnormal_xenobiotic_induced0.75513525
116MP0002009_preneoplasia0.70390131
117MP0003795_abnormal_bone_structure0.70298229
118MP0000490_abnormal_crypts_of0.69322332
119MP0005075_abnormal_melanosome_morpholog0.67960126
120MP0000249_abnormal_blood_vessel0.66959981
121MP0003221_abnormal_cardiomyocyte_apopto0.66244399
122MP0004264_abnormal_extraembryonic_tissu0.64824463
123MP0000015_abnormal_ear_pigmentation0.64742036
124MP0003045_fibrosis0.64584955
125MP0004808_abnormal_hematopoietic_stem0.63473749
126MP0001873_stomach_inflammation0.62935261
127MP0000569_abnormal_digit_pigmentation0.60457174
128MP0006054_spinal_hemorrhage0.59464960
129MP0005083_abnormal_biliary_tract0.59193122
130MP0008874_decreased_physiological_sensi0.58431840
131MP0002332_abnormal_exercise_endurance0.58320036
132MP0002933_joint_inflammation0.55619352
133MP0003091_abnormal_cell_migration0.54761090
134MP0005388_respiratory_system_phenotype0.53015481
135MP0002133_abnormal_respiratory_system0.53015481

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)5.82642487
2Recurrent gram-negative bacterial infections (HP:0005420)5.76443442
3Recurrent bacterial skin infections (HP:0005406)5.66792919
4Eczematoid dermatitis (HP:0000976)5.51077734
5Obstructive lung disease (HP:0006536)3.83391372
6Chronic obstructive pulmonary disease (HP:0006510)3.83391372
7Abnormality of complement system (HP:0005339)3.70336166
8Increased neuronal autofluorescent lipopigment (HP:0002074)3.63121221
9Systemic lupus erythematosus (HP:0002725)3.57245442
10Xanthomatosis (HP:0000991)3.54758153
11Recurrent skin infections (HP:0001581)3.51409543
12Deep venous thrombosis (HP:0002625)3.47208075
13Increased cerebral lipofuscin (HP:0011813)3.45958383
14Myositis (HP:0100614)3.38842436
15Abnormality of macrophages (HP:0004311)3.32123819
16Complement deficiency (HP:0004431)3.23307857
17Prolonged partial thromboplastin time (HP:0003645)3.23226751
18Pustule (HP:0200039)3.23153742
19Elevated erythrocyte sedimentation rate (HP:0003565)3.22804994
20Gingivitis (HP:0000230)3.22700356
21Joint hemorrhage (HP:0005261)3.22609201
22Mediastinal lymphadenopathy (HP:0100721)3.18759076
23Abnormality of monocarboxylic acid metabolism (HP:0010996)3.17876218
24Amyloidosis (HP:0011034)3.14296149
25Hypochromic microcytic anemia (HP:0004840)3.12093751
26Myocardial infarction (HP:0001658)3.08937504
27Urticaria (HP:0001025)3.02347842
28Intrahepatic cholestasis (HP:0001406)2.99849489
29Chest pain (HP:0100749)2.96541146
30Episodic fever (HP:0001954)2.95315914
31Pulmonary infiltrates (HP:0002113)2.95258045
32Gastrointestinal infarctions (HP:0005244)2.91242361
33Loss of speech (HP:0002371)2.90343403
34Gingival bleeding (HP:0000225)2.88889869
35Recurrent fungal infections (HP:0002841)2.88770620
36Prolonged bleeding time (HP:0003010)2.87925933
37Abnormality of aromatic amino acid family metabolism (HP:0004338)2.85520759
38Spontaneous hematomas (HP:0007420)2.82035206
39Orchitis (HP:0100796)2.80409353
40Nephritis (HP:0000123)2.75291972
41Hypobetalipoproteinemia (HP:0003563)2.71100274
42Increased IgE level (HP:0003212)2.70753813
43Leukocytosis (HP:0001974)2.70064103
44Petechiae (HP:0000967)2.64934083
45Hyperlipoproteinemia (HP:0010980)2.62214572
46T lymphocytopenia (HP:0005403)2.62081516
47Hypochromic anemia (HP:0001931)2.61463805
48Abnormality of fatty-acid metabolism (HP:0004359)2.61274625
49Vasculitis (HP:0002633)2.60623813
50Meningitis (HP:0001287)2.57416723
51Abnormality of the common coagulation pathway (HP:0010990)2.56881626
52Periodontitis (HP:0000704)2.56502287
53Glomerulonephritis (HP:0000099)2.54696713
54Osteomyelitis (HP:0002754)2.54108329
55Abnormality of T cell number (HP:0011839)2.51840923
56Abnormality of liposaccharide metabolism (HP:0010968)2.48897483
57Abnormality of glycosphingolipid metabolism (HP:0004343)2.48897483
58Abnormality of glycolipid metabolism (HP:0010969)2.48897483
59Epidermoid cyst (HP:0200040)2.46996423
60Colitis (HP:0002583)2.46839061
61Cellulitis (HP:0100658)2.46195302
62Hyperglycinuria (HP:0003108)2.44138341
63Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.42347237
64Thick nail (HP:0001805)2.39881621
65Disinhibition (HP:0000734)2.38557477
66Interstitial pulmonary disease (HP:0006530)2.37145895
67Keratoconjunctivitis sicca (HP:0001097)2.36549299
68Vacuolated lymphocytes (HP:0001922)2.36036086
69Hypolipoproteinemia (HP:0010981)2.35904559
70Increased IgM level (HP:0003496)2.34742404
71Hypoalphalipoproteinemia (HP:0003233)2.34494105
72Increased serum ferritin (HP:0003281)2.34227677
73Peritonitis (HP:0002586)2.33492985
74Retrobulbar optic neuritis (HP:0100654)2.31179703
75Optic neuritis (HP:0100653)2.31179703
76Hyperammonemia (HP:0001987)2.31126349
77Abnormality of glutamine family amino acid metabolism (HP:0010902)2.30382466
78Chronic otitis media (HP:0000389)2.29888522
79Stomatitis (HP:0010280)2.28840972
80Gastrointestinal inflammation (HP:0004386)2.28785609
81Dysostosis multiplex (HP:0000943)2.28653081
82Purpura (HP:0000979)2.28508080
83Abnormality of the pleura (HP:0002103)2.26251915
84Pulmonary embolism (HP:0002204)2.24582687
85Hepatosplenomegaly (HP:0001433)2.24444742
86Abnormality of iron homeostasis (HP:0011031)2.23926920
87Abnormality of pyrimidine metabolism (HP:0004353)2.23333635
88Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.23105686
89Hemoptysis (HP:0002105)2.22113705
90Vertigo (HP:0002321)2.17825895
91Recurrent viral infections (HP:0004429)2.16428092
92Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.14841245
93Inflammation of the large intestine (HP:0002037)2.14320541
94Polycythemia (HP:0001901)2.14229295
95Hematochezia (HP:0002573)2.14110084
96Abnormality of the peritoneum (HP:0002585)2.13377040
97Premature loss of primary teeth (HP:0006323)2.13303944
98Abnormality of T cells (HP:0002843)2.12464429
99Mitral stenosis (HP:0001718)2.12434354
100Microcytic anemia (HP:0001935)2.11587954
101Keratoconjunctivitis (HP:0001096)2.11190018
102Sepsis (HP:0100806)2.10611425
103Hypergammaglobulinemia (HP:0010702)2.10506277
104Hypoglycemic coma (HP:0001325)2.09096631
105Abnormal platelet volume (HP:0011876)2.08671651
106Gangrene (HP:0100758)2.08111098
107Chronic mucocutaneous candidiasis (HP:0002728)2.07695445
108Recurrent cutaneous fungal infections (HP:0011370)2.07695445
109Fat malabsorption (HP:0002630)2.07653952
110Granulocytopenia (HP:0001913)2.07454484
111Anorexia (HP:0002039)2.07223170
112Abnormality of glycine metabolism (HP:0010895)2.06699487
113Abnormality of serine family amino acid metabolism (HP:0010894)2.06699487
114Glomerulopathy (HP:0100820)2.06513867
115Polyneuropathy (HP:0001271)2.05726835
116Osteolytic defects of the hand bones (HP:0009699)2.05576884
117Osteolytic defects of the phalanges of the hand (HP:0009771)2.05576884
118Encephalitis (HP:0002383)2.05551779
119Arterial thrombosis (HP:0004420)2.05209310
120Malnutrition (HP:0004395)2.05194329
121Autoimmune thrombocytopenia (HP:0001973)2.04241311
122Amaurosis fugax (HP:0100576)2.02910717
123Thrombophlebitis (HP:0004418)2.02654181
124Abnormality of the endocardium (HP:0004306)2.01894847
125Skin ulcer (HP:0200042)2.01710064
126Hyperglycinemia (HP:0002154)1.99785910
127Abnormal delayed hypersensitivity skin test (HP:0002963)1.98672475
128Acrocyanosis (HP:0001063)1.98467623
129Abnormality of transition element cation homeostasis (HP:0011030)1.98021175
130Parakeratosis (HP:0001036)1.97464681
131Acne (HP:0001061)1.96476616
132Poor head control (HP:0002421)1.95048433
133Esophageal varix (HP:0002040)1.93568774
134Epistaxis (HP:0000421)1.93103537
135Abnormality of the pericardium (HP:0001697)1.87260688
136Skin rash (HP:0000988)1.86536585
137Cheilitis (HP:0100825)1.86113130
138Recurrent pneumonia (HP:0006532)1.85227179
139Keratitis (HP:0000491)1.84717352
140Progressive neurologic deterioration (HP:0002344)1.83681156
141Panhypogammaglobulinemia (HP:0003139)1.82887991
142Abnormality of mucopolysaccharide metabolism (HP:0011020)1.81423027
143Abnormality of polysaccharide metabolism (HP:0011012)1.81423027
144Abnormality of glycosaminoglycan metabolism (HP:0004371)1.81423027

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BLK4.44114791
2MAP3K143.53792635
3MAP4K13.49987011
4IRAK43.16963308
5RIPK43.03454507
6ERN13.01879883
7TYK22.99555774
8CSK2.58140765
9IRAK32.47007439
10PRPF4B2.40989178
11TBK12.39146784
12CSF1R2.36737774
13FGFR42.17926925
14EPHB12.10835113
15TNK21.97150538
16MAP2K31.94951039
17MAP3K121.78020938
18FGR1.76321417
19IKBKB1.70330192
20MAP3K31.69870334
21TAOK31.64577268
22TRIB31.64323667
23BCKDK1.56533304
24NEK91.54123687
25TEC1.53237350
26JAK11.52610741
27KIT1.51846797
28GRK11.51788063
29BTK1.46929185
30STK101.45437366
31FLT31.44857795
32LRRK21.40981015
33KSR21.40725368
34ZAP701.38825631
35JAK31.35494031
36SYK1.34130266
37YES11.29620486
38MST1R1.26954047
39ITK1.26916918
40IKBKE1.25883497
41CDK191.23899497
42HCK1.21748939
43JAK21.18808794
44TGFBR21.13515723
45IRAK11.12552803
46FGFR31.12410706
47SIK31.12069151
48IRAK21.08251470
49EPHA31.05868461
50MAP3K21.04207782
51GRK61.03378904
52LYN1.00724524
53MATK0.95656108
54MAP3K130.94710944
55TRPM70.92118893
56TESK20.91250793
57TXK0.90243162
58CHUK0.89273383
59STK240.88959015
60KDR0.87737068
61NUAK10.84786898
62PDK10.81477454
63MAP3K110.81410117
64PIK3CG0.81271528
65MAP3K50.80962467
66MARK20.80930633
67RPS6KA40.80055803
68PIM10.78182186
69SIK10.73579191
70MYLK0.72830312
71CLK10.72802783
72MST40.72235428
73TTN0.70308252
74MAP2K60.70057598
75PDPK10.69611688
76PTK60.69159404
77MARK30.63951014
78FYN0.62918179
79ABL20.62652584
80MAPK70.60483311
81TAOK10.60266383
82LCK0.60230879
83CDC42BPA0.59658889
84FES0.59552839
85STK30.58652226
86NME20.57227461
87PRKAA20.56622469
88MAP2K40.56492501
89MAPK120.56001226
90PRKD20.54876572
91PTK2B0.54131000
92KSR10.53423391
93ABL10.52563933
94MAPKAPK20.51492247
95MOS0.51303693
96PRKCD0.50444558
97PKN20.49630851
98ERBB30.48923913
99BMPR20.48651587
100GRK70.48485039
101MAPK110.46732253
102FRK0.45776507
103RPS6KC10.45711124
104RPS6KL10.45711124
105MAP3K70.45527732
106EIF2AK20.45447226
107PRKG20.44792012
108SGK30.43046615
109STK40.42734785
110CAMK1D0.41868086
111MAPK40.41469851
112MAP3K10.41363313
113NLK0.41017987
114RAF10.40784443
115RET0.39572893
116PRKCQ0.38858163
117MAP2K20.38211648
118ACVR1B0.37659603
119SMG10.37427954
120TAOK20.37304801
121PTK20.36976602
122RPS6KA60.36170349
123SIK20.33810006
124EGFR0.31902824
125RIPK10.31420584
126DAPK20.31220720
127CAMKK20.30938001
128MAP3K60.27736691
129HIPK20.27642933
130STK110.27533157
131BMX0.27348616
132CDK60.26865172
133PAK40.26596351
134DYRK1B0.26572323
135MAP3K80.26164389

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051503.83751362
2Primary bile acid biosynthesis_Homo sapiens_hsa001203.06693091
3Complement and coagulation cascades_Homo sapiens_hsa046102.56361826
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.34986206
5Autoimmune thyroid disease_Homo sapiens_hsa053202.28075604
6Leishmaniasis_Homo sapiens_hsa051402.27509219
7Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.22728570
8Fatty acid degradation_Homo sapiens_hsa000712.18737078
9Tryptophan metabolism_Homo sapiens_hsa003802.03939530
10Fatty acid metabolism_Homo sapiens_hsa012122.01718391
11Fatty acid elongation_Homo sapiens_hsa000622.00089627
12Caffeine metabolism_Homo sapiens_hsa002321.95552493
13PPAR signaling pathway_Homo sapiens_hsa033201.90814380
14Histidine metabolism_Homo sapiens_hsa003401.87056405
15Arginine biosynthesis_Homo sapiens_hsa002201.86098440
16Other glycan degradation_Homo sapiens_hsa005111.84820446
17Pentose and glucuronate interconversions_Homo sapiens_hsa000401.81935567
18Type I diabetes mellitus_Homo sapiens_hsa049401.79566431
19Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.77333544
20Nitrogen metabolism_Homo sapiens_hsa009101.74675742
21Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.67400794
22Toll-like receptor signaling pathway_Homo sapiens_hsa046201.60650922
23beta-Alanine metabolism_Homo sapiens_hsa004101.53804849
24Peroxisome_Homo sapiens_hsa041461.51956799
25Osteoclast differentiation_Homo sapiens_hsa043801.49083539
26Retinol metabolism_Homo sapiens_hsa008301.46851946
27Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.46260705
28Phenylalanine metabolism_Homo sapiens_hsa003601.44189948
29Pertussis_Homo sapiens_hsa051331.41930836
30Propanoate metabolism_Homo sapiens_hsa006401.41576103
31NF-kappa B signaling pathway_Homo sapiens_hsa040641.38179893
32Legionellosis_Homo sapiens_hsa051341.37058053
33Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.33932219
34Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.33762162
35Fat digestion and absorption_Homo sapiens_hsa049751.30037555
36T cell receptor signaling pathway_Homo sapiens_hsa046601.28775590
37Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.27738352
38Chemical carcinogenesis_Homo sapiens_hsa052041.27469233
39Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.25242558
40Tuberculosis_Homo sapiens_hsa051521.24457340
41NOD-like receptor signaling pathway_Homo sapiens_hsa046211.19170569
42ABC transporters_Homo sapiens_hsa020101.16866495
43Intestinal immune network for IgA production_Homo sapiens_hsa046721.16680209
44Drug metabolism - other enzymes_Homo sapiens_hsa009831.16630349
45B cell receptor signaling pathway_Homo sapiens_hsa046621.11682843
46Graft-versus-host disease_Homo sapiens_hsa053321.09184608
47Steroid hormone biosynthesis_Homo sapiens_hsa001401.07032477
48Starch and sucrose metabolism_Homo sapiens_hsa005001.06698054
49Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.03014521
50Vitamin B6 metabolism_Homo sapiens_hsa007501.02380427
51Pentose phosphate pathway_Homo sapiens_hsa000301.02238181
52Hepatitis B_Homo sapiens_hsa051611.00909499
53Vitamin digestion and absorption_Homo sapiens_hsa049771.00155487
54Lysosome_Homo sapiens_hsa041420.99447006
55Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.98485677
56Leukocyte transendothelial migration_Homo sapiens_hsa046700.97909882
57Salmonella infection_Homo sapiens_hsa051320.96553527
58Toxoplasmosis_Homo sapiens_hsa051450.96131320
59Malaria_Homo sapiens_hsa051440.94546922
60Butanoate metabolism_Homo sapiens_hsa006500.93446985
61Non-small cell lung cancer_Homo sapiens_hsa052230.91031978
62Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.89247863
63Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.87027781
64Selenocompound metabolism_Homo sapiens_hsa004500.85915044
65Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.84890748
66Chemokine signaling pathway_Homo sapiens_hsa040620.84731969
67Tyrosine metabolism_Homo sapiens_hsa003500.84197038
68TNF signaling pathway_Homo sapiens_hsa046680.82675706
69Influenza A_Homo sapiens_hsa051640.81937938
70Antigen processing and presentation_Homo sapiens_hsa046120.81189177
71Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.80750414
72Carbon metabolism_Homo sapiens_hsa012000.79768058
73Pancreatic cancer_Homo sapiens_hsa052120.79283917
74Folate biosynthesis_Homo sapiens_hsa007900.77377113
75VEGF signaling pathway_Homo sapiens_hsa043700.76184332
76African trypanosomiasis_Homo sapiens_hsa051430.74184685
77Shigellosis_Homo sapiens_hsa051310.74103237
78SNARE interactions in vesicular transport_Homo sapiens_hsa041300.73776877
792-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.73049320
80Adipocytokine signaling pathway_Homo sapiens_hsa049200.72797840
81Herpes simplex infection_Homo sapiens_hsa051680.72539911
82Chronic myeloid leukemia_Homo sapiens_hsa052200.71465966
83Renal cell carcinoma_Homo sapiens_hsa052110.70672524
84RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.70533559
85Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.70513740
86Measles_Homo sapiens_hsa051620.69827215
87Prolactin signaling pathway_Homo sapiens_hsa049170.69499396
88Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.69286779
89Carbohydrate digestion and absorption_Homo sapiens_hsa049730.68686259
90Sphingolipid signaling pathway_Homo sapiens_hsa040710.68139943
91Endocytosis_Homo sapiens_hsa041440.67809321
92Glycerolipid metabolism_Homo sapiens_hsa005610.67188665
93Neurotrophin signaling pathway_Homo sapiens_hsa047220.66604894
94Insulin resistance_Homo sapiens_hsa049310.66331873
95Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.65998845
96Jak-STAT signaling pathway_Homo sapiens_hsa046300.65417359
97AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.64340378
98Hematopoietic cell lineage_Homo sapiens_hsa046400.63573385
99Epstein-Barr virus infection_Homo sapiens_hsa051690.59596800
100Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.59558234
101Phagosome_Homo sapiens_hsa041450.56266776
102HIF-1 signaling pathway_Homo sapiens_hsa040660.55774042
103Collecting duct acid secretion_Homo sapiens_hsa049660.55313247
104GnRH signaling pathway_Homo sapiens_hsa049120.55255264
105Allograft rejection_Homo sapiens_hsa053300.55231604
106Bile secretion_Homo sapiens_hsa049760.54257675
107Apoptosis_Homo sapiens_hsa042100.54064664
108Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.54032946
109Hepatitis C_Homo sapiens_hsa051600.53984529
110Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.53571459
111Glycosaminoglycan degradation_Homo sapiens_hsa005310.52841900
112Viral myocarditis_Homo sapiens_hsa054160.52804558
113Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.52249436
114Primary immunodeficiency_Homo sapiens_hsa053400.51661541
115Phospholipase D signaling pathway_Homo sapiens_hsa040720.50771047
116Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.50296043
117Amoebiasis_Homo sapiens_hsa051460.50137852
118FoxO signaling pathway_Homo sapiens_hsa040680.49490874
119Notch signaling pathway_Homo sapiens_hsa043300.49321426
120Sulfur metabolism_Homo sapiens_hsa009200.48618524
121Fatty acid biosynthesis_Homo sapiens_hsa000610.48247511
122Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.48059421
123Pyruvate metabolism_Homo sapiens_hsa006200.46348166
124Acute myeloid leukemia_Homo sapiens_hsa052210.45919624
125Regulation of autophagy_Homo sapiens_hsa041400.45003848
126Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.44958766
127Dorso-ventral axis formation_Homo sapiens_hsa043200.44222153
128Choline metabolism in cancer_Homo sapiens_hsa052310.43841899
129Biosynthesis of amino acids_Homo sapiens_hsa012300.41343858
130Viral carcinogenesis_Homo sapiens_hsa052030.41168901
131Type II diabetes mellitus_Homo sapiens_hsa049300.40860276
132Galactose metabolism_Homo sapiens_hsa000520.40454964
133HTLV-I infection_Homo sapiens_hsa051660.40022821
134Rheumatoid arthritis_Homo sapiens_hsa053230.39559232
135Endometrial cancer_Homo sapiens_hsa052130.39506714
136Phosphatidylinositol signaling system_Homo sapiens_hsa040700.38389476
137Asthma_Homo sapiens_hsa053100.37714834
138Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.36682126
139Platelet activation_Homo sapiens_hsa046110.35974676
140Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.35404047
141Bladder cancer_Homo sapiens_hsa052190.34107999
142Glycerophospholipid metabolism_Homo sapiens_hsa005640.33995326
143Inositol phosphate metabolism_Homo sapiens_hsa005620.32072117
144Transcriptional misregulation in cancer_Homo sapiens_hsa052020.31552496
145mTOR signaling pathway_Homo sapiens_hsa041500.30104662
146Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.28357427
147Rap1 signaling pathway_Homo sapiens_hsa040150.27645285

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