PLCB2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a phosphodiesterase that catalyzes the hydrolysis of phosphatidylinositol 4,5-bisphosphate to the second messengers inositol 1,4,5-trisphosphate (IP3) and diacylglycerol. The encoded protein is activated by G proteins and has been shown to be involved in the type 2 taste receptor signal transduction pathway. In addition, nuclear factor kappa B can regulate the transcription of this gene, whose protein product is also an important regulator of platelet responses. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)5.91870135
2antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.44580141
3antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.44580141
4positive regulation of B cell differentiation (GO:0045579)5.07899988
5antigen processing and presentation of endogenous antigen (GO:0019883)5.04368063
6antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.91095788
7detection of other organism (GO:0098543)4.88491754
8detection of bacterium (GO:0016045)4.73297035
9regulation of gamma-delta T cell differentiation (GO:0045586)4.45277817
10regulation of B cell differentiation (GO:0045577)4.28633977
11antigen processing and presentation via MHC class Ib (GO:0002475)4.23448909
12definitive hemopoiesis (GO:0060216)4.21862676
13regulation of gamma-delta T cell activation (GO:0046643)4.20586905
14regulation of B cell receptor signaling pathway (GO:0050855)4.14977024
15detection of external biotic stimulus (GO:0098581)4.06404572
16ribosomal small subunit assembly (GO:0000028)4.02880762
17negative regulation of lymphocyte mediated immunity (GO:0002707)4.01481709
18negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.00411053
19negative regulation of cell killing (GO:0031342)4.00411053
20leukocyte aggregation (GO:0070486)3.96797339
21megakaryocyte development (GO:0035855)3.96091717
22positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.92965515
23B cell receptor signaling pathway (GO:0050853)3.88661495
24regulation of myeloid leukocyte mediated immunity (GO:0002886)3.86391328
25microglial cell activation (GO:0001774)3.80088280
26negative regulation of phagocytosis (GO:0050765)3.79412178
27negative regulation of T cell mediated immunity (GO:0002710)3.76440048
28detection of molecule of bacterial origin (GO:0032490)3.74930855
29positive regulation of mast cell activation (GO:0033005)3.74681929
30negative regulation of erythrocyte differentiation (GO:0045647)3.72166084
31response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.70786166
32response to host immune response (GO:0052572)3.70786166
33negative regulation of leukocyte mediated immunity (GO:0002704)3.67060133
34regulation of mast cell activation involved in immune response (GO:0033006)3.66240868
35regulation of leukocyte degranulation (GO:0043300)3.64821493
36detection of biotic stimulus (GO:0009595)3.62510782
37regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.62007105
38positive thymic T cell selection (GO:0045059)3.54954577
39macrophage activation (GO:0042116)3.52420680
40mast cell activation (GO:0045576)3.49806572
41T cell homeostasis (GO:0043029)3.44141544
42response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.42797969
43response to host (GO:0075136)3.42797969
44response to host defenses (GO:0052200)3.42797969
45immunoglobulin mediated immune response (GO:0016064)3.42426281
46positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.41488106
47activated T cell proliferation (GO:0050798)3.40559635
48positive regulation of mast cell activation involved in immune response (GO:0033008)3.35091623
49positive regulation of mast cell degranulation (GO:0043306)3.35091623
50Arp2/3 complex-mediated actin nucleation (GO:0034314)3.34507359
51leukocyte migration involved in inflammatory response (GO:0002523)3.34458575
52respiratory burst (GO:0045730)3.32571545
53mature B cell differentiation (GO:0002335)3.31372877
54regulation of interferon-beta biosynthetic process (GO:0045357)3.31193375
55regulation of T cell tolerance induction (GO:0002664)3.30609049
56regulation of tolerance induction (GO:0002643)3.30533215
57neutrophil activation involved in immune response (GO:0002283)3.29203994
58myeloid dendritic cell activation (GO:0001773)3.28065474
59cellular extravasation (GO:0045123)3.27948559
60response to peptidoglycan (GO:0032494)3.26141608
61germinal center formation (GO:0002467)3.26134163
62modulation by symbiont of host immune response (GO:0052553)3.26067586
63positive regulation by symbiont of host defense response (GO:0052509)3.26067586
64modulation by symbiont of host defense response (GO:0052031)3.26067586
65modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.26067586
66modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.26067586
67positive regulation by organism of defense response of other organism involved in symbiotic interact3.26067586
68neutrophil mediated immunity (GO:0002446)3.24524172
69pinocytosis (GO:0006907)3.23358850
70negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.22354440
71mature B cell differentiation involved in immune response (GO:0002313)3.15674859
72positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.14592227
73response to protozoan (GO:0001562)3.12493075
74regulation of dendritic cell antigen processing and presentation (GO:0002604)3.12074818
75positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.11629034
76response to muramyl dipeptide (GO:0032495)3.09458717
77regulation of regulated secretory pathway (GO:1903305)3.08302640
78positive regulation of myeloid leukocyte mediated immunity (GO:0002888)3.07932911
79defense response to protozoan (GO:0042832)3.06981535
80interferon-gamma-mediated signaling pathway (GO:0060333)3.05836599
81lymphocyte homeostasis (GO:0002260)3.05154535
82regulation of interleukin-12 biosynthetic process (GO:0045075)3.04907129
83regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.03368008
84myeloid cell activation involved in immune response (GO:0002275)3.02099800
85mast cell degranulation (GO:0043303)3.01954296
86mast cell activation involved in immune response (GO:0002279)3.01954296
87negative thymic T cell selection (GO:0045060)2.99660504
88regulation of antigen processing and presentation (GO:0002577)2.99097616
89B cell homeostasis (GO:0001782)2.97976270
90regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.97870186
91regulation of erythrocyte differentiation (GO:0045646)2.97416489
92positive regulation of granulocyte differentiation (GO:0030854)2.97211131
93neutrophil activation (GO:0042119)2.95398850
94negative regulation of granulocyte differentiation (GO:0030853)2.95346916
95negative regulation of interleukin-6 production (GO:0032715)2.95224454
96negative T cell selection (GO:0043383)2.95219444
97negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.94167715
98negative regulation of innate immune response (GO:0045824)2.92679319
99cellular response to interleukin-15 (GO:0071350)2.92672422
100production of molecular mediator involved in inflammatory response (GO:0002532)2.92526284
101leukocyte homeostasis (GO:0001776)2.90417200
102positive regulation of cellular amide metabolic process (GO:0034250)2.88613988
103cellular response to zinc ion (GO:0071294)2.87211175
104lymph node development (GO:0048535)2.86872550
105negative regulation of cytokine production involved in immune response (GO:0002719)2.86574642
106regulation of T-helper 2 cell differentiation (GO:0045628)2.86317795
107NIK/NF-kappaB signaling (GO:0038061)2.85086272
108negative regulation of interleukin-12 production (GO:0032695)2.84915655
109response to fungus (GO:0009620)2.83938070
110B cell mediated immunity (GO:0019724)2.79989680
111response to interferon-beta (GO:0035456)2.79365712
112myeloid dendritic cell differentiation (GO:0043011)2.77808644
113response to interleukin-15 (GO:0070672)2.77185600
114embryonic hemopoiesis (GO:0035162)2.77013489
115T cell migration (GO:0072678)2.76812661
116regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.76792035
117macrophage activation involved in immune response (GO:0002281)2.75160500
118regulation of necroptotic process (GO:0060544)2.74584946
119positive regulation of antigen processing and presentation (GO:0002579)2.72333235
120interferon-gamma production (GO:0032609)2.71639644
121natural killer cell differentiation (GO:0001779)2.71493943
122response to type I interferon (GO:0034340)2.70962502
123viral transcription (GO:0019083)2.70560488
124positive T cell selection (GO:0043368)2.69409149
125granulocyte activation (GO:0036230)2.68460696
126thymic T cell selection (GO:0045061)2.68058729
127leukocyte degranulation (GO:0043299)2.66907574
128type I interferon signaling pathway (GO:0060337)2.66003684
129cellular response to type I interferon (GO:0071357)2.66003684
130regulation of granulocyte differentiation (GO:0030852)2.65313582
131leukocyte cell-cell adhesion (GO:0007159)2.63990838
132antigen receptor-mediated signaling pathway (GO:0050851)2.62244455
133cellular response to interferon-beta (GO:0035458)2.61536718
134tolerance induction (GO:0002507)2.59096996
135positive regulation of natural killer cell differentiation (GO:0032825)2.57585537
136T cell selection (GO:0045058)2.55807313
137regulation of mast cell degranulation (GO:0043304)2.55438017
138defense response to fungus (GO:0050832)2.55055466
139positive regulation of interferon-alpha production (GO:0032727)2.55032977
140actin nucleation (GO:0045010)2.54493204
141angiogenesis involved in wound healing (GO:0060055)2.54300105
142hepatocyte apoptotic process (GO:0097284)2.53542795
143translational termination (GO:0006415)2.53414925
144regulation of mast cell activation (GO:0033003)2.52841267

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.20664326
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.18694685
3SCL_19346495_ChIP-Seq_HPC-7_Human3.94451514
4MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.87138130
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.57207224
6EGR1_19374776_ChIP-ChIP_THP-1_Human3.33570772
7IRF8_21731497_ChIP-ChIP_J774_Mouse3.30712956
8IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.15702939
9MYC_22102868_ChIP-Seq_BL_Human3.06530576
10MYB_21317192_ChIP-Seq_ERMYB_Mouse3.04151309
11BP1_19119308_ChIP-ChIP_Hs578T_Human3.00463346
12FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.99817782
13* VDR_21846776_ChIP-Seq_THP-1_Human2.97058160
14SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.92295503
15SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.81943657
16RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.76639075
17SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.73922925
18* IRF8_27001747_Chip-Seq_BMDM_Mouse2.67559275
19NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.56165938
20* SPI1_23547873_ChIP-Seq_NB4_Human2.54281437
21MYB_26560356_Chip-Seq_TH2_Human2.29905282
22* VDR_24763502_ChIP-Seq_THP-1_Human2.27905606
23RUNX1_22412390_ChIP-Seq_EML_Mouse2.24076311
24MAF_26560356_Chip-Seq_TH1_Human2.22209454
25FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.21596140
26IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.19582147
27RUNX_20019798_ChIP-Seq_JUKART_Human2.18454581
28BRD4_27068464_Chip-Seq_AML-cells_Mouse2.18088347
29STAT4_19710469_ChIP-ChIP_TH1__Mouse2.17365429
30STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.15943326
31FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.15335697
32ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.13049254
33* MYB_26560356_Chip-Seq_TH1_Human2.11918640
34TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.10381213
35TCF7_22412390_ChIP-Seq_EML_Mouse2.09506494
36ELF1_17652178_ChIP-ChIP_JURKAT_Human1.99872536
37UTX_26944678_Chip-Seq_JUKART_Human1.99639331
38NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.91932296
39* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.90622646
40SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.89257494
41SPI1_23127762_ChIP-Seq_K562_Human1.88611193
42GATA1_22025678_ChIP-Seq_K562_Human1.86231296
43VDR_24787735_ChIP-Seq_THP-1_Human1.78833690
44FOXM1_23109430_ChIP-Seq_U2OS_Human1.77117057
45EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.76571423
46E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.75393004
47LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.74979830
48NOTCH1_21737748_ChIP-Seq_TLL_Human1.68184075
49SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.64810140
50THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.63627722
51LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.63235395
52CIITA_25753668_ChIP-Seq_RAJI_Human1.61928732
53E2F4_17652178_ChIP-ChIP_JURKAT_Human1.60802483
54ERG_20887958_ChIP-Seq_HPC-7_Mouse1.60788745
55GATA2_22383799_ChIP-Seq_G1ME_Mouse1.60170048
56NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.58705768
57* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.56178436
58CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.53780708
59STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.53546192
60GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.51953687
61HOXB4_20404135_ChIP-ChIP_EML_Mouse1.49693542
62LXR_22292898_ChIP-Seq_THP-1_Human1.45419524
63PU_27001747_Chip-Seq_BMDM_Mouse1.43754090
64* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.43501612
65MAF_26560356_Chip-Seq_TH2_Human1.38971650
66* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.37550598
67GATA3_27048872_Chip-Seq_THYMUS_Human1.37255464
68* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.36609228
69* GATA1_19941827_ChIP-Seq_MEL_Mouse1.35408898
70GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.32605994
71GATA1_19941826_ChIP-Seq_K562_Human1.31436720
72* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.30501540
73KDM2B_26808549_Chip-Seq_JURKAT_Human1.30260607
74SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.28398200
75Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.27175161
76IKZF1_21737484_ChIP-ChIP_HCT116_Human1.27082767
77PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.23022248
78CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.20610348
79* KDM2B_26808549_Chip-Seq_DND41_Human1.16617566
80ELK3_25401928_ChIP-Seq_HUVEC_Human1.16443494
81FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.13761650
82VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.13089600
83SMAD_19615063_ChIP-ChIP_OVARY_Human1.12266425
84FOXP3_21729870_ChIP-Seq_TREG_Human1.09193830
85* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.08469771
86BCL6_27268052_Chip-Seq_Bcells_Human1.06501995
87STAT6_21828071_ChIP-Seq_BEAS2B_Human1.06334393
88VDR_23849224_ChIP-Seq_CD4+_Human1.04273437
89RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.04040776
90VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.02969927
91* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.02444478
92PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.00805074
93BCOR_27268052_Chip-Seq_Bcells_Human1.00243227
94MYC_18555785_ChIP-Seq_MESCs_Mouse0.99325077
95RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.98919800
96TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.98580354
97SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.97854282
98E2F1_21310950_ChIP-Seq_MCF-7_Human0.97585277
99GATA2_19941826_ChIP-Seq_K562_Human0.97335457
100FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.95827520
101* CTCF_27219007_Chip-Seq_ERYTHROID_Human0.94688344
102PU.1_20513432_ChIP-Seq_Bcells_Mouse0.94670171
103* GATA3_26560356_Chip-Seq_TH2_Human0.94578493
104TFEB_21752829_ChIP-Seq_HELA_Human0.91893584
105* ETS1_22383799_ChIP-Seq_G1ME_Mouse0.91858520
106GATA2_21666600_ChIP-Seq_HMVEC_Human0.87536533
107NCOR1_26117541_ChIP-Seq_K562_Human0.87464831
108* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.86313250
109SPI1_20517297_ChIP-Seq_HL60_Human0.86070621
110* ELF1_20517297_ChIP-Seq_JURKAT_Human0.85526092
111SA1_27219007_Chip-Seq_ERYTHROID_Human0.84820523
112* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.84553842
113NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.84115800
114FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.82652388
115* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.81038093
116* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.80913877
117* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.80617737
118PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.76696834
119EST1_17652178_ChIP-ChIP_JURKAT_Human0.74680468

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.93142511
2MP0002396_abnormal_hematopoietic_system3.59395218
3MP0000685_abnormal_immune_system3.01517303
4MP0005671_abnormal_response_to2.87431470
5MP0004808_abnormal_hematopoietic_stem2.85882465
6* MP0001800_abnormal_humoral_immune2.84545476
7MP0003303_peritoneal_inflammation2.84335984
8MP0005174_abnormal_tail_pigmentation2.72466865
9MP0003436_decreased_susceptibility_to2.69247246
10* MP0002452_abnormal_antigen_presenting2.61592896
11* MP0005464_abnormal_platelet_physiology2.59919475
12MP0009785_altered_susceptibility_to2.59562523
13MP0005387_immune_system_phenotype2.55810116
14MP0001790_abnormal_immune_system2.55810116
15* MP0005025_abnormal_response_to2.54089025
16* MP0002419_abnormal_innate_immunity2.54020061
17MP0005000_abnormal_immune_tolerance2.52233173
18* MP0002420_abnormal_adaptive_immunity2.50646917
19* MP0002723_abnormal_immune_serum2.49892115
20MP0009278_abnormal_bone_marrow2.48963275
21MP0002398_abnormal_bone_marrow2.48532837
22* MP0001819_abnormal_immune_cell2.48475722
23MP0003763_abnormal_thymus_physiology2.45385858
24MP0005397_hematopoietic_system_phenotyp2.40257675
25MP0001545_abnormal_hematopoietic_system2.40257675
26MP0002148_abnormal_hypersensitivity_rea2.21290383
27MP0000716_abnormal_immune_system2.20275509
28MP0000465_gastrointestinal_hemorrhage2.17161304
29MP0000689_abnormal_spleen_morphology2.13786986
30MP0001873_stomach_inflammation2.13212094
31MP0002722_abnormal_immune_system2.05366915
32MP0002405_respiratory_system_inflammati2.05193189
33MP0002166_altered_tumor_susceptibility2.00737393
34MP0002429_abnormal_blood_cell1.92192465
35MP0003300_gastrointestinal_ulcer1.90645017
36MP0008260_abnormal_autophagy1.90290858
37MP0010155_abnormal_intestine_physiology1.86706307
38MP0000569_abnormal_digit_pigmentation1.85977465
39MP0003172_abnormal_lysosome_physiology1.76762073
40MP0000703_abnormal_thymus_morphology1.76338229
41MP0001853_heart_inflammation1.75249555
42MP0003724_increased_susceptibility_to1.72940623
43MP0006082_CNS_inflammation1.72799125
44MP0005058_abnormal_lysosome_morphology1.71370338
45MP0005075_abnormal_melanosome_morpholog1.71035818
46MP0001845_abnormal_inflammatory_respons1.67778406
47MP0003183_abnormal_peptide_metabolism1.67205245
48MP0009333_abnormal_splenocyte_physiolog1.65891465
49MP0000490_abnormal_crypts_of1.61085698
50MP0004947_skin_inflammation1.57006478
51MP0002006_tumorigenesis1.54785812
52MP0003866_abnormal_defecation1.49428788
53MP0005451_abnormal_body_composition1.45227084
54MP0000015_abnormal_ear_pigmentation1.36741305
55MP0002095_abnormal_skin_pigmentation1.34896245
56MP0004883_abnormal_blood_vessel1.30746409
57MP0003693_abnormal_embryo_hatching1.28372259
58MP0001533_abnormal_skeleton_physiology1.26924767
59MP0008469_abnormal_protein_level1.26273887
60MP0003690_abnormal_glial_cell1.25997753
61MP0004510_myositis1.24319578
62MP0010094_abnormal_chromosome_stability1.20919124
63MP0004381_abnormal_hair_follicle1.19602290
64MP0003191_abnormal_cellular_cholesterol1.18717854
65MP0001851_eye_inflammation1.18368766
66MP0008057_abnormal_DNA_replication1.15868714
67MP0000858_altered_metastatic_potential1.09853095
68MP0005310_abnormal_salivary_gland1.09564393
69MP0008004_abnormal_stomach_pH1.07206084
70MP0003077_abnormal_cell_cycle1.07178521
71MP0010307_abnormal_tumor_latency1.06752385
72MP0002019_abnormal_tumor_incidence1.06267608
73MP0000604_amyloidosis1.04991132
74MP0005166_decreased_susceptibility_to1.04731734
75MP0002933_joint_inflammation0.99201401
76MP0002009_preneoplasia0.95293138
77MP0005164_abnormal_response_to0.95122424
78MP0000343_altered_response_to0.90328369
79MP0002277_abnormal_respiratory_mucosa0.88897444
80MP0003111_abnormal_nucleus_morphology0.87841530
81MP0003943_abnormal_hepatobiliary_system0.86485528
82MP0005390_skeleton_phenotype0.84813225
83MP0008007_abnormal_cellular_replicative0.84810408
84MP0003566_abnormal_cell_adhesion0.84602118
85MP0010352_gastrointestinal_tract_polyps0.84329763
86MP0000371_diluted_coat_color0.83514902
87MP0003448_altered_tumor_morphology0.82781265
88MP0001663_abnormal_digestive_system0.82241895
89MP0000313_abnormal_cell_death0.82021653
90MP0008058_abnormal_DNA_repair0.81048704
91MP0009764_decreased_sensitivity_to0.79436908
92MP0003828_pulmonary_edema0.77865311
93MP0003656_abnormal_erythrocyte_physiolo0.75017448
94MP0002998_abnormal_bone_remodeling0.74463511
95MP0009763_increased_sensitivity_to0.71442942
96MP0009840_abnormal_foam_cell0.68574278
97MP0006054_spinal_hemorrhage0.67016336
98MP0002132_abnormal_respiratory_system0.66702736
99MP0002928_abnormal_bile_duct0.66213932
100MP0003806_abnormal_nucleotide_metabolis0.65989470
101MP0002138_abnormal_hepatobiliary_system0.65548320
102MP0003091_abnormal_cell_migration0.64677063
103MP0005076_abnormal_cell_differentiation0.64391894
104MP0004130_abnormal_muscle_cell0.61737726
105MP0003045_fibrosis0.61360730
106MP0005409_darkened_coat_color0.60432561
107MP0002075_abnormal_coat/hair_pigmentati0.59911432
108MP0002877_abnormal_melanocyte_morpholog0.58812317
109MP0008874_decreased_physiological_sensi0.58482188
110MP0009765_abnormal_xenobiotic_induced0.57150674
111MP0005023_abnormal_wound_healing0.56110709
112MP0000249_abnormal_blood_vessel0.55440544
113MP0000598_abnormal_liver_morphology0.55060287
114MP0003795_abnormal_bone_structure0.54164959
115MP0003075_altered_response_to0.54114686
116MP0008873_increased_physiological_sensi0.53367558
117MP0000477_abnormal_intestine_morphology0.52859796
118MP0009115_abnormal_fat_cell0.50086646
119MP0004147_increased_porphyrin_level0.48402118
120MP0000920_abnormal_myelination0.48353061
121MP0005388_respiratory_system_phenotype0.48257832
122MP0002133_abnormal_respiratory_system0.48257832
123MP0005319_abnormal_enzyme/_coenzyme0.46192019
124MP0005381_digestive/alimentary_phenotyp0.44972887
125MP0003329_amyloid_beta_deposits0.44164134
126MP0003279_aneurysm0.42730652

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)5.34763967
2Recurrent bacterial skin infections (HP:0005406)5.00995180
3Eczematoid dermatitis (HP:0000976)4.77105891
4Thrombocytosis (HP:0001894)4.74563663
5IgM deficiency (HP:0002850)4.70361521
6Recurrent fungal infections (HP:0002841)4.30579063
7Recurrent viral infections (HP:0004429)4.11858645
8Chronic otitis media (HP:0000389)4.08731473
9Myositis (HP:0100614)3.90071584
10Cellulitis (HP:0100658)3.75851583
11Prolonged bleeding time (HP:0003010)3.75192398
12Elevated erythrocyte sedimentation rate (HP:0003565)3.71871164
13Abnormal delayed hypersensitivity skin test (HP:0002963)3.71014231
14Recurrent skin infections (HP:0001581)3.62742924
15Gastrointestinal infarctions (HP:0005244)3.61859894
16Meningitis (HP:0001287)3.48537280
17Panhypogammaglobulinemia (HP:0003139)3.48203479
18Petechiae (HP:0000967)3.45432409
19Recurrent bronchitis (HP:0002837)3.39172926
20Abnormality of the fingertips (HP:0001211)3.34700540
21Mediastinal lymphadenopathy (HP:0100721)3.33823729
22Nasal polyposis (HP:0100582)3.31431239
23Recurrent gram-negative bacterial infections (HP:0005420)3.30600583
24Recurrent cutaneous fungal infections (HP:0011370)3.26509215
25Chronic mucocutaneous candidiasis (HP:0002728)3.26509215
26Obstructive lung disease (HP:0006536)3.23988435
27Chronic obstructive pulmonary disease (HP:0006510)3.23988435
28Gastrointestinal inflammation (HP:0004386)3.19320600
29Impaired platelet aggregation (HP:0003540)3.12800532
30Abnormal platelet function (HP:0011869)3.12800532
31Inflammation of the large intestine (HP:0002037)3.12629794
32Epistaxis (HP:0000421)3.10265357
33Keratoconjunctivitis sicca (HP:0001097)3.09009117
34Abnormality of macrophages (HP:0004311)3.08530417
35Abnormality of the nasal mucosa (HP:0000433)3.06499987
36Agammaglobulinemia (HP:0004432)3.06392057
37Periodontitis (HP:0000704)2.91180597
38Abnormality of T cell physiology (HP:0011840)2.85044396
39Abnormality of B cell number (HP:0010975)2.84615016
40B lymphocytopenia (HP:0010976)2.84615016
41Keratoconjunctivitis (HP:0001096)2.83199655
42Abnormality of T cells (HP:0002843)2.83025598
43Colitis (HP:0002583)2.82482478
44Vasculitis (HP:0002633)2.80865794
45Abnormality of liposaccharide metabolism (HP:0010968)2.76732064
46Abnormality of glycosphingolipid metabolism (HP:0004343)2.76732064
47Abnormality of glycolipid metabolism (HP:0010969)2.76732064
48Spontaneous hematomas (HP:0007420)2.75674770
49Gingival bleeding (HP:0000225)2.72117354
50Amyloidosis (HP:0011034)2.66766065
51Lymphopenia (HP:0001888)2.64206749
52Pustule (HP:0200039)2.64129425
53Systemic lupus erythematosus (HP:0002725)2.63421940
54T lymphocytopenia (HP:0005403)2.61671772
55Thyroiditis (HP:0100646)2.61119190
56Chest pain (HP:0100749)2.60983718
57Acute myeloid leukemia (HP:0004808)2.60407362
58Gastrointestinal stroma tumor (HP:0100723)2.58034488
59Episodic fever (HP:0001954)2.55929309
60Leukocytosis (HP:0001974)2.53920512
61Granulocytopenia (HP:0001913)2.53025495
62Abnormality of cells of the lymphoid lineage (HP:0012140)2.52943067
63Orchitis (HP:0100796)2.52012215
64Osteomyelitis (HP:0002754)2.51871442
65Gingivitis (HP:0000230)2.50753888
66Pulmonary embolism (HP:0002204)2.50323318
67Autoimmune thrombocytopenia (HP:0001973)2.49859252
68Eosinophilia (HP:0001880)2.47916632
69Hypochromic microcytic anemia (HP:0004840)2.47702747
70Interstitial pulmonary disease (HP:0006530)2.45403990
71Abnormality of T cell number (HP:0011839)2.45039453
72Aplastic anemia (HP:0001915)2.43008281
73Vacuolated lymphocytes (HP:0001922)2.41379842
74Arterial thrombosis (HP:0004420)2.39896731
75Increased IgE level (HP:0003212)2.39375270
76Loss of speech (HP:0002371)2.37021663
77Purpura (HP:0000979)2.36884168
78Abnormality of cells of the erythroid lineage (HP:0012130)2.36517717
79Abnormality of the prostate (HP:0008775)2.35309438
80Dysostosis multiplex (HP:0000943)2.34223240
81Increased cerebral lipofuscin (HP:0011813)2.33694713
82Increased neuronal autofluorescent lipopigment (HP:0002074)2.33179849
83Abnormal number of erythroid precursors (HP:0012131)2.32651270
84Abnormality of eosinophils (HP:0001879)2.31067641
85IgG deficiency (HP:0004315)2.30023593
86Anorexia (HP:0002039)2.28038116
87Stomatitis (HP:0010280)2.26874444
88Myelodysplasia (HP:0002863)2.26490392
89Amaurosis fugax (HP:0100576)2.25670971
90Optic neuritis (HP:0100653)2.25073459
91Retrobulbar optic neuritis (HP:0100654)2.25073459
92Increased IgM level (HP:0003496)2.24675550
93Reticulocytopenia (HP:0001896)2.22506880
94Thoracic kyphosis (HP:0002942)2.21465308
95Hemoptysis (HP:0002105)2.19206120
96Increased serum ferritin (HP:0003281)2.18160679
97Hepatosplenomegaly (HP:0001433)2.18103034
98Lymphoma (HP:0002665)2.16738627
99Albinism (HP:0001022)2.16537561
100Viral hepatitis (HP:0006562)2.16214136
101Sepsis (HP:0100806)2.15496287
102Hypergammaglobulinemia (HP:0010702)2.15302814
103Encephalitis (HP:0002383)2.15168611
104Hypoplasia of the thymus (HP:0000778)2.12443607
105IgA deficiency (HP:0002720)2.11745018
106Acute lymphatic leukemia (HP:0006721)2.11451979
107Abnormality of iron homeostasis (HP:0011031)2.10367119
108Papilloma (HP:0012740)2.08555895
109Verrucae (HP:0200043)2.08555895
110Abnormal platelet volume (HP:0011876)2.08441077
111Cheilitis (HP:0100825)2.08198700
112Abnormality of the pleura (HP:0002103)2.08136209
113Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.06722648
114Recurrent sinusitis (HP:0011108)2.06648969
115Abnormality of the thoracic spine (HP:0100711)2.03744070
116Chronic diarrhea (HP:0002028)2.03341872
117Peritonitis (HP:0002586)2.02657481
118Pulmonary infiltrates (HP:0002113)2.02012619
119Microcytic anemia (HP:0001935)2.00665028
120Hypochromic anemia (HP:0001931)2.00403380
121Agnosia (HP:0010524)1.98478382
122Chronic sinusitis (HP:0011109)1.97781808
123Skin ulcer (HP:0200042)1.97209003
124Fatigue (HP:0012378)1.96623145
125Hematochezia (HP:0002573)1.96489187
126Gangrene (HP:0100758)1.96412475
127Urticaria (HP:0001025)1.95369140
128Slow saccadic eye movements (HP:0000514)1.94291061
129Premature loss of primary teeth (HP:0006323)1.93245590
130Abnormality of the endocardium (HP:0004306)1.93214727
131Glomerulopathy (HP:0100820)1.91765692
132Abnormality of the peritoneum (HP:0002585)1.91287794
133Polygenic inheritance (HP:0010982)1.91271762
134Vertigo (HP:0002321)1.90875156
135Restrictive lung disease (HP:0002091)1.88020664
136Disinhibition (HP:0000734)1.85727566

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.81272080
2KIT2.82809170
3PRPF4B2.82611051
4EEF2K2.80330450
5IRAK42.68508908
6BTK2.53944507
7TXK2.44548129
8JAK32.32177539
9ZAP702.22329796
10CSF1R2.02574276
11BLK2.01731612
12TYK22.01294991
13TEC2.00867647
14SYK1.88997064
15TAOK31.88373535
16TGFBR21.85709856
17STK101.84008311
18SIK21.76553774
19RIPK41.75814984
20FES1.71043471
21MAP2K31.69214055
22TBK11.63092315
23FGR1.62687195
24MAP3K31.62320740
25HCK1.61015696
26FLT31.57215912
27GRK61.56511963
28IRAK31.52989982
29IKBKE1.49176032
30PKN21.46430986
31TAOK11.46237078
32MAP3K141.45076542
33MAP3K101.42811026
34MAP3K111.42663482
35ITK1.36343371
36LCK1.35019611
37ERN11.30674175
38NME21.27229268
39FGFR31.25897504
40MATK1.22639761
41IKBKB1.21655535
42LRRK21.18338301
43LYN1.18194214
44MAP3K11.15600290
45PIM11.13622174
46MARK21.13060594
47RPS6KA41.06298925
48TGFBR11.06214755
49MAP3K131.04405329
50JAK11.04192651
51TRPM71.02895358
52NEK21.02191725
53CLK11.00777439
54CSK1.00393027
55SIK30.99952491
56YES10.98500079
57RPS6KB20.98388980
58EPHB10.97002305
59BMPR20.96382335
60KSR20.93652266
61STK40.90223758
62CDC42BPA0.88435671
63PRKD20.87931489
64MAPK70.86840891
65CDC70.86789551
66MAPK120.86317025
67MARK30.82576658
68TNK20.79354169
69PDPK10.78362865
70CDK120.78301050
71SMG10.78210525
72CDK40.77647119
73TRIB30.77510921
74PIM20.77378798
75JAK20.74193133
76TAOK20.73393593
77CDK60.71781259
78IRAK10.71561597
79MAP3K60.71410635
80MAPKAPK50.71169525
81IRAK20.70919435
82ATR0.70563437
83HIPK20.70367736
84CAMK1D0.68138475
85PIK3CG0.67789203
86VRK10.66471118
87CHUK0.66463580
88PAK40.65808547
89PTK60.63755806
90FYN0.63137509
91MAPK40.61812603
92WEE10.61119942
93RPS6KA60.60728777
94FGFR40.59141346
95GRK70.57467631
96CAMK1G0.57273811
97TESK20.56699665
98PDK10.55545638
99CDK190.55348912
100NEK90.54477764
101CAMKK10.53896602
102MAPKAPK30.53373575
103SGK30.53285360
104RPS6KL10.50940462
105RPS6KC10.50940462
106DYRK1B0.50364526
107NLK0.48528815
108STK240.46301357
109MAPKAPK20.46189329
110STK110.46186134
111SIK10.46094843
112RPS6KA20.44299439
113RET0.43675178
114MAPK110.43078530
115MAP3K80.43061466
116DYRK30.43047076
117PASK0.40692964
118TIE10.40155507
119MOS0.39516926
120PTK2B0.39344326
121MAP3K50.39332877
122CDK90.38995692
123ALK0.38608025
124BRSK20.38380385
125MAP3K120.37159385
126MKNK10.36032497
127PRKCQ0.35752743
128CDK70.35541336
129MAP3K70.34747509
130SGK20.34740758
131TTN0.34063308
132ABL10.33336550
133MAP2K60.33002864
134CAMKK20.32808873
135MAPK30.32224541
136MAP2K20.31571783
137MAP3K20.31486502
138MAP2K40.31461322

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053403.16076617
2B cell receptor signaling pathway_Homo sapiens_hsa046622.80596784
3Leishmaniasis_Homo sapiens_hsa051402.74187081
4Osteoclast differentiation_Homo sapiens_hsa043802.35754005
5Autoimmune thyroid disease_Homo sapiens_hsa053202.29932104
6NF-kappa B signaling pathway_Homo sapiens_hsa040642.28496290
7DNA replication_Homo sapiens_hsa030302.21932885
8Antigen processing and presentation_Homo sapiens_hsa046122.08479414
9Measles_Homo sapiens_hsa051622.04415829
10Hematopoietic cell lineage_Homo sapiens_hsa046402.03589619
11Other glycan degradation_Homo sapiens_hsa005111.96541197
12Intestinal immune network for IgA production_Homo sapiens_hsa046721.93355064
13Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.92164534
14Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.89345064
15Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.87182688
16RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.81291063
17Toll-like receptor signaling pathway_Homo sapiens_hsa046201.81220445
18Type I diabetes mellitus_Homo sapiens_hsa049401.80805500
19Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.76321290
20Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.74640016
21Ribosome_Homo sapiens_hsa030101.73195275
22Herpes simplex infection_Homo sapiens_hsa051681.72628650
23NOD-like receptor signaling pathway_Homo sapiens_hsa046211.67773735
24T cell receptor signaling pathway_Homo sapiens_hsa046601.60428436
25Jak-STAT signaling pathway_Homo sapiens_hsa046301.56830329
26Acute myeloid leukemia_Homo sapiens_hsa052211.56481470
27Mismatch repair_Homo sapiens_hsa034301.56382371
28Glycosaminoglycan degradation_Homo sapiens_hsa005311.51390638
29Staphylococcus aureus infection_Homo sapiens_hsa051501.45337641
30Transcriptional misregulation in cancer_Homo sapiens_hsa052021.44672085
31Tuberculosis_Homo sapiens_hsa051521.42349326
32Base excision repair_Homo sapiens_hsa034101.40985153
33Pertussis_Homo sapiens_hsa051331.40934718
34Influenza A_Homo sapiens_hsa051641.40237815
35Shigellosis_Homo sapiens_hsa051311.37229904
36Legionellosis_Homo sapiens_hsa051341.36855153
37Hepatitis B_Homo sapiens_hsa051611.36691758
38* Platelet activation_Homo sapiens_hsa046111.36567678
39Toxoplasmosis_Homo sapiens_hsa051451.31987783
40Homologous recombination_Homo sapiens_hsa034401.31593321
41Leukocyte transendothelial migration_Homo sapiens_hsa046701.31178419
42Chronic myeloid leukemia_Homo sapiens_hsa052201.29712921
43Non-homologous end-joining_Homo sapiens_hsa034501.26434744
44Apoptosis_Homo sapiens_hsa042101.25808825
45* Chemokine signaling pathway_Homo sapiens_hsa040621.21213004
46* Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.21039655
47Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.16043945
48Asthma_Homo sapiens_hsa053101.13843741
49Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.13063846
50TNF signaling pathway_Homo sapiens_hsa046681.10358013
51Malaria_Homo sapiens_hsa051441.10065785
52Neurotrophin signaling pathway_Homo sapiens_hsa047221.03389805
53Epstein-Barr virus infection_Homo sapiens_hsa051690.97722317
54Pancreatic cancer_Homo sapiens_hsa052120.96101890
55Spliceosome_Homo sapiens_hsa030400.95496925
56Salmonella infection_Homo sapiens_hsa051320.92996910
57Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.91830640
58Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.90389365
59Non-small cell lung cancer_Homo sapiens_hsa052230.90188511
60Allograft rejection_Homo sapiens_hsa053300.89840467
61Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.88408123
62Lysosome_Homo sapiens_hsa041420.85225516
63Viral carcinogenesis_Homo sapiens_hsa052030.84357775
64Renal cell carcinoma_Homo sapiens_hsa052110.81099305
65Hepatitis C_Homo sapiens_hsa051600.79125080
66Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.78578240
67Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.78576212
68Fanconi anemia pathway_Homo sapiens_hsa034600.77837182
69HTLV-I infection_Homo sapiens_hsa051660.77123691
70Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.76998560
71Cell cycle_Homo sapiens_hsa041100.75891664
72Viral myocarditis_Homo sapiens_hsa054160.72519189
73Caffeine metabolism_Homo sapiens_hsa002320.71936022
74* AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.71477680
75Endocytosis_Homo sapiens_hsa041440.70326188
76Notch signaling pathway_Homo sapiens_hsa043300.70094651
77* Phospholipase D signaling pathway_Homo sapiens_hsa040720.69426712
78* African trypanosomiasis_Homo sapiens_hsa051430.68557693
79Choline metabolism in cancer_Homo sapiens_hsa052310.68449149
80Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.67831082
81Sulfur relay system_Homo sapiens_hsa041220.67449907
82Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.67050017
83Graft-versus-host disease_Homo sapiens_hsa053320.66518314
84Nucleotide excision repair_Homo sapiens_hsa034200.65612717
85Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.64273617
86* Phosphatidylinositol signaling system_Homo sapiens_hsa040700.63412568
87N-Glycan biosynthesis_Homo sapiens_hsa005100.63332513
88RNA degradation_Homo sapiens_hsa030180.62160984
89* Sphingolipid signaling pathway_Homo sapiens_hsa040710.61647361
90Prolactin signaling pathway_Homo sapiens_hsa049170.58290191
91Dorso-ventral axis formation_Homo sapiens_hsa043200.58250754
92Endometrial cancer_Homo sapiens_hsa052130.57869089
93* GnRH signaling pathway_Homo sapiens_hsa049120.56999444
94Adipocytokine signaling pathway_Homo sapiens_hsa049200.56063773
95Small cell lung cancer_Homo sapiens_hsa052220.55700929
96Colorectal cancer_Homo sapiens_hsa052100.54561807
97ABC transporters_Homo sapiens_hsa020100.53589655
98VEGF signaling pathway_Homo sapiens_hsa043700.53088744
99Glycerophospholipid metabolism_Homo sapiens_hsa005640.51906098
100* Carbohydrate digestion and absorption_Homo sapiens_hsa049730.51876196
101Rheumatoid arthritis_Homo sapiens_hsa053230.51686369
102* Amoebiasis_Homo sapiens_hsa051460.51126836
103Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.50524677
104Lysine degradation_Homo sapiens_hsa003100.50184672
105Pentose phosphate pathway_Homo sapiens_hsa000300.49425835
106p53 signaling pathway_Homo sapiens_hsa041150.48975011
107Pyrimidine metabolism_Homo sapiens_hsa002400.47843066
108MAPK signaling pathway_Homo sapiens_hsa040100.47764743
109* Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.45590653
110Type II diabetes mellitus_Homo sapiens_hsa049300.45291257
111Phagosome_Homo sapiens_hsa041450.44678602
112Insulin resistance_Homo sapiens_hsa049310.42039626
113* Inositol phosphate metabolism_Homo sapiens_hsa005620.41332598
114HIF-1 signaling pathway_Homo sapiens_hsa040660.40264762
115Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.39507015
116Regulation of autophagy_Homo sapiens_hsa041400.38674503
117* Rap1 signaling pathway_Homo sapiens_hsa040150.38185113
118ErbB signaling pathway_Homo sapiens_hsa040120.37941824
119Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.36138725
120FoxO signaling pathway_Homo sapiens_hsa040680.35896459
121mTOR signaling pathway_Homo sapiens_hsa041500.35144685
122SNARE interactions in vesicular transport_Homo sapiens_hsa041300.34837911
123Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.33853815
124Regulation of actin cytoskeleton_Homo sapiens_hsa048100.33732624
125Prostate cancer_Homo sapiens_hsa052150.33396976
126Renin-angiotensin system_Homo sapiens_hsa046140.32957699
127RNA transport_Homo sapiens_hsa030130.32094205
128One carbon pool by folate_Homo sapiens_hsa006700.31792677
129MicroRNAs in cancer_Homo sapiens_hsa052060.29818960

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