PLCB3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the phosphoinositide phospholipase C beta enzyme family that catalyze the production of the secondary messengers diacylglycerol and inositol 1,4,5-triphosphate from phosphatidylinositol in G-protein-linked receptor-mediated signal transduction. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of podosome assembly (GO:0071801)9.58801530
2negative regulation of peptidyl-lysine acetylation (GO:2000757)7.84418716
3negative regulation of B cell apoptotic process (GO:0002903)7.54391745
4negative regulation of histone acetylation (GO:0035067)7.20648969
5negative regulation of protein acetylation (GO:1901984)6.50275613
6bundle of His cell to Purkinje myocyte communication (GO:0086069)6.23279764
7gastrulation with mouth forming second (GO:0001702)5.80744188
8intestinal absorption (GO:0050892)5.22111900
9hypotonic response (GO:0006971)5.07717911
10regulation of B cell apoptotic process (GO:0002902)4.94172050
11intestinal cholesterol absorption (GO:0030299)4.93011022
12positive regulation of organelle assembly (GO:1902117)4.87455978
13chromatin assembly (GO:0031497)4.74433164
14hemidesmosome assembly (GO:0031581)4.72531884
15basement membrane organization (GO:0071711)4.55114467
16sodium ion export (GO:0071436)4.36028758
17positive regulation of myotube differentiation (GO:0010831)4.33449098
18Golgi transport vesicle coating (GO:0048200)4.26206470
19COPI coating of Golgi vesicle (GO:0048205)4.26206470
20NADH metabolic process (GO:0006734)4.10526585
21angiotensin maturation (GO:0002003)4.07381985
22positive regulation of Cdc42 GTPase activity (GO:0043089)3.92264237
23proline biosynthetic process (GO:0006561)3.81832165
24intestinal epithelial cell development (GO:0060576)3.67452912
25dendritic cell chemotaxis (GO:0002407)3.66031531
26desmosome organization (GO:0002934)3.60433363
27cytoskeletal anchoring at plasma membrane (GO:0007016)3.59443902
28protein retention in ER lumen (GO:0006621)3.58991667
29actin filament depolymerization (GO:0030042)3.56899029
30maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.54028163
31barbed-end actin filament capping (GO:0051016)3.45058735
32epithelial cell-cell adhesion (GO:0090136)3.43874039
33regulation of cholesterol homeostasis (GO:2000188)3.43824383
34protein localization to endosome (GO:0036010)3.43296904
35activation of Rac GTPase activity (GO:0032863)3.43004164
36adherens junction assembly (GO:0034333)3.39695552
37cellular potassium ion homeostasis (GO:0030007)3.39262579
38regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.26388255
39urea cycle (GO:0000050)3.23955618
40embryonic process involved in female pregnancy (GO:0060136)3.23320668
41vitamin A metabolic process (GO:0006776)3.23189157
42focal adhesion assembly (GO:0048041)3.21781052
43cell-substrate adherens junction assembly (GO:0007045)3.21781052
44cellular response to nutrient (GO:0031670)3.18266809
45planar cell polarity pathway involved in neural tube closure (GO:0090179)3.16330052
46branching involved in mammary gland duct morphogenesis (GO:0060444)3.16067242
47regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.14595007
48notochord development (GO:0030903)3.14473120
49glucose 6-phosphate metabolic process (GO:0051156)3.13079597
50adhesion of symbiont to host cell (GO:0044650)3.11406610
51virion attachment to host cell (GO:0019062)3.11406610
52glycosphingolipid catabolic process (GO:0046479)3.09073670
53positive regulation of pseudopodium assembly (GO:0031274)3.08966470
54hormone catabolic process (GO:0042447)3.06939775
55maintenance of gastrointestinal epithelium (GO:0030277)3.06071824
56regulation of early endosome to late endosome transport (GO:2000641)3.02365287
57semaphorin-plexin signaling pathway (GO:0071526)3.02211732
58peptide catabolic process (GO:0043171)3.01095487
59gastrulation (GO:0007369)3.00296707
60retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.00019495
61negative regulation of fatty acid transport (GO:2000192)2.98394612
62regulation of integrin activation (GO:0033623)2.96526015
63regulation of protein heterodimerization activity (GO:0043497)2.91820264
64regulation of extracellular matrix disassembly (GO:0010715)2.91363344
65glycolipid catabolic process (GO:0019377)2.90643533
66positive regulation of p38MAPK cascade (GO:1900745)2.90504618
67epithelial structure maintenance (GO:0010669)2.90364259
68urea metabolic process (GO:0019627)2.90085750
69regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.88024807
70fructose metabolic process (GO:0006000)2.87726493
71regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.86838854
72potassium ion homeostasis (GO:0055075)2.85787363
73cell-substrate junction assembly (GO:0007044)2.84156625
74gap junction assembly (GO:0016264)2.82282099
75cellular response to UV (GO:0034644)2.81184777
76renal system process involved in regulation of blood volume (GO:0001977)2.80679835
77cell migration involved in gastrulation (GO:0042074)2.79089222
78dendritic cell migration (GO:0036336)2.76810793
79apoptotic process involved in morphogenesis (GO:0060561)2.76766825
80endocardial cushion development (GO:0003197)2.74249447
81glutamine family amino acid biosynthetic process (GO:0009084)2.72684610
82regulation of vitamin metabolic process (GO:0030656)2.71948342
83dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.71173152
84regulation of peptidyl-lysine acetylation (GO:2000756)2.70716742
85negative regulation of chondrocyte differentiation (GO:0032331)2.70568902
86low-density lipoprotein particle clearance (GO:0034383)2.69092208
87adhesion of symbiont to host (GO:0044406)2.69079074
88regulation of glucose import in response to insulin stimulus (GO:2001273)2.68843458
89regulation of pseudopodium assembly (GO:0031272)2.67845956
90membrane repolarization (GO:0086009)2.67818540
91cellular response to osmotic stress (GO:0071470)2.66121920
92cell adhesion mediated by integrin (GO:0033627)2.65763710
93proline metabolic process (GO:0006560)2.65632846
94regulation of tight junction assembly (GO:2000810)2.64489344
95regulation of guanylate cyclase activity (GO:0031282)2.64348537
96negative regulation of histone modification (GO:0031057)2.62152630
97digestive system process (GO:0022600)2.62102716
98lipoprotein metabolic process (GO:0042157)2.60726742
99potassium ion export (GO:0071435)2.60459726
100pinocytosis (GO:0006907)2.59312050
101cellular response to hepatocyte growth factor stimulus (GO:0035729)2.59086193
102response to hepatocyte growth factor (GO:0035728)2.59086193
103triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.57248613
104plasma membrane repair (GO:0001778)2.57175350
105cell communication involved in cardiac conduction (GO:0086065)2.56538675
106fat-soluble vitamin biosynthetic process (GO:0042362)2.56089348
107protein heterotrimerization (GO:0070208)2.55881790
108actin filament bundle organization (GO:0061572)2.55715865
109actin filament bundle assembly (GO:0051017)2.55715865
110midgut development (GO:0007494)2.55710257
111cellular sodium ion homeostasis (GO:0006883)2.54178965
112paraxial mesoderm development (GO:0048339)2.53439988
113mannose metabolic process (GO:0006013)2.52635661
114negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.51418297
115maternal placenta development (GO:0001893)2.48874436
116phospholipid efflux (GO:0033700)2.48697095
117regulation of hippo signaling (GO:0035330)2.47785421
118positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.47737510
119regulation of protein acetylation (GO:1901983)2.47270490
120nitrogen cycle metabolic process (GO:0071941)2.47204967
121negative regulation of cell size (GO:0045792)2.46530178
122peptide hormone processing (GO:0016486)2.45735259
123apoptotic cell clearance (GO:0043277)2.45666317
124protein complex localization (GO:0031503)2.45648546
125regulation of p38MAPK cascade (GO:1900744)2.44899359
126epithelial cell differentiation involved in prostate gland development (GO:0060742)2.43621832
127endothelial cell chemotaxis (GO:0035767)2.43494698
128endothelial cell morphogenesis (GO:0001886)2.43375047
129renal filtration (GO:0097205)2.42845067
130protein-lipid complex assembly (GO:0065005)2.42194796
131multicellular organismal macromolecule metabolic process (GO:0044259)2.41903858
132cellular protein complex localization (GO:0034629)2.40966573
133cellular response to epidermal growth factor stimulus (GO:0071364)2.40709465
134establishment or maintenance of bipolar cell polarity (GO:0061245)2.40513135
135establishment or maintenance of apical/basal cell polarity (GO:0035088)2.40513135
136lipoprotein transport (GO:0042953)2.40423403
137negative regulation of cholesterol transport (GO:0032375)2.39641556
138negative regulation of sterol transport (GO:0032372)2.39641556
139endocytic recycling (GO:0032456)2.39400514
140regulation of systemic arterial blood pressure by hormone (GO:0001990)2.38911492
141regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)2.38911492
142endocrine process (GO:0050886)2.38911492
143regulation of bile acid biosynthetic process (GO:0070857)2.38708936
144receptor catabolic process (GO:0032801)2.38089182
145regulation of histone acetylation (GO:0035065)2.37997786
146heterochromatin organization (GO:0070828)2.36736837
147regulation of mammary gland epithelial cell proliferation (GO:0033599)2.36639141
148hippo signaling (GO:0035329)2.36556416
149stress fiber assembly (GO:0043149)2.35913078
150multicellular organismal catabolic process (GO:0044243)2.35188338
151pentose-phosphate shunt (GO:0006098)2.35088874
152negative regulation of chromatin modification (GO:1903309)2.34243966
153trophectodermal cell differentiation (GO:0001829)2.33916106
154negative regulation of catenin import into nucleus (GO:0035414)2.33714046
155UDP-N-acetylglucosamine metabolic process (GO:0006047)2.32972877
156drug catabolic process (GO:0042737)2.32428683
157sulfur amino acid catabolic process (GO:0000098)2.31607424
158endodermal cell differentiation (GO:0035987)2.30981922
159negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.29881758
160negative regulation of lymphocyte apoptotic process (GO:0070229)2.29263926
161establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.28726529
162plasma lipoprotein particle assembly (GO:0034377)2.28434315
163negative regulation of sodium ion transport (GO:0010766)2.27176330
164intermediate filament organization (GO:0045109)2.26870265
165establishment of apical/basal cell polarity (GO:0035089)2.26201921
166homocysteine metabolic process (GO:0050667)2.26036625
167regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.24905966
168anterior/posterior axis specification, embryo (GO:0008595)2.22577531
169skin morphogenesis (GO:0043589)2.20935412
170hyperosmotic salinity response (GO:0042538)2.20379547
171modified amino acid transport (GO:0072337)2.19722096

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human6.86588172
2ESR1_15608294_ChIP-ChIP_MCF-7_Human3.76334908
3CDX2_20551321_ChIP-Seq_CACO-2_Human2.65180658
4NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.58150272
5ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.53521059
6TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.51955002
7NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.46766052
8ESR2_21235772_ChIP-Seq_MCF-7_Human2.39888087
9ZNF263_19887448_ChIP-Seq_K562_Human2.33088008
10PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.32539415
11RARG_19884340_ChIP-ChIP_MEFs_Mouse2.31516796
12CLOCK_20551151_ChIP-Seq_293T_Human2.28779583
13KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human2.20113410
14TRIM28_21343339_ChIP-Seq_HEK293_Human2.18820851
15NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.16565997
16STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.14075319
17ESR1_21235772_ChIP-Seq_MCF-7_Human2.07954942
18E2F7_22180533_ChIP-Seq_HELA_Human2.06314647
19* ELK3_25401928_ChIP-Seq_HUVEC_Human2.04953789
20RXR_22158963_ChIP-Seq_LIVER_Mouse2.03342948
21ERG_21242973_ChIP-ChIP_JURKAT_Human2.01476797
22PPARA_22158963_ChIP-Seq_LIVER_Mouse1.98584022
23SOX2_27498859_Chip-Seq_STOMACH_Mouse1.96988628
24VDR_21846776_ChIP-Seq_THP-1_Human1.94134777
25RACK7_27058665_Chip-Seq_MCF-7_Human1.91645548
26MYC_22102868_ChIP-Seq_BL_Human1.90893748
27SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.90227261
28GATA6_25053715_ChIP-Seq_YYC3_Human1.83864972
29EGR1_19374776_ChIP-ChIP_THP-1_Human1.80653890
30KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.74400274
31ATF3_27146783_Chip-Seq_COLON_Human1.72137975
32HIF1A_21447827_ChIP-Seq_MCF-7_Human1.68803034
33THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.68057728
34KDM2B_26808549_Chip-Seq_SUP-B15_Human1.65971974
35EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.65049286
36MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.63575191
37POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.62010284
38P300_27058665_Chip-Seq_ZR-75-30cells_Human1.61556918
39* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.58555908
40SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.55269649
41TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.54989115
42FOXM1_23109430_ChIP-Seq_U2OS_Human1.54349203
43* LXR_22292898_ChIP-Seq_THP-1_Human1.53990510
44SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.53962664
45STAT3_1855785_ChIP-Seq_MESCs_Mouse1.53760339
46TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.53532212
47* KDM2B_26808549_Chip-Seq_DND41_Human1.50770560
48LXR_22158963_ChIP-Seq_LIVER_Mouse1.50756078
49* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.50579653
50TCF3_18692474_ChIP-Seq_MEFs_Mouse1.50401015
51CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.47297647
52PPAR_26484153_Chip-Seq_NCI-H1993_Human1.46900067
53GATA4_25053715_ChIP-Seq_YYC3_Human1.44487448
54RUNX1_27514584_Chip-Seq_MCF-7_Human1.44027973
55SOX9_24532713_ChIP-Seq_HFSC_Mouse1.41703624
56KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.41438277
57KLF4_18555785_ChIP-Seq_MESCs_Mouse1.40264330
58ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.39382739
59KLF5_25053715_ChIP-Seq_YYC3_Human1.39124691
60* KDM2B_26808549_Chip-Seq_K562_Human1.39057304
61SOX2_20726797_ChIP-Seq_SW620_Human1.38079756
62* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.37956513
63KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.36015885
64KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.36015885
65KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.36015885
66* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.34833500
67DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.34533749
68CREB1_26743006_Chip-Seq_LNCaP_Human1.34060575
69FOXO3_23340844_ChIP-Seq_DLD1_Human1.32791296
70* TET1_21451524_ChIP-Seq_MESCs_Mouse1.32640975
71ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.30849613
72RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.29178922
73NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.28692243
74SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.26315759
75SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.26315759
76TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.25199713
77UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.20172348
78ZFP281_27345836_Chip-Seq_ESCs_Mouse1.19556364
79CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.19401389
80AR_21909140_ChIP-Seq_LNCAP_Human1.15783461
81NCOR1_26117541_ChIP-Seq_K562_Human1.15359164
82RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.15203242
83* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.14744184
84SALL4_18804426_ChIP-ChIP_XEN_Mouse1.14328320
85VDR_24763502_ChIP-Seq_THP-1_Human1.12439807
86EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.11375324
87* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.11326590
88SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.09553448
89TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.09425132
90SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.08481904
91UBF1/2_26484160_Chip-Seq_HMECs_Human1.07721301
92SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.07319353
93* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.06930302
94GATA1_19941826_ChIP-Seq_K562_Human1.06676284
95TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.06264185
96SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.06088874
97EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.05874470
98P68_20966046_ChIP-Seq_HELA_Human1.05547808
99SA1_27219007_Chip-Seq_ERYTHROID_Human1.03861897
100HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.03683128
101BRD4_27068464_Chip-Seq_AML-cells_Mouse1.03317960
102TP53_22127205_ChIP-Seq_IMR90_Human1.03086351
103TCF4_18268006_ChIP-ChIP_LS174T_Human1.02874087
104GATA1_22383799_ChIP-Seq_G1ME_Mouse1.02257101
105FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.02100964
106CTCF_27219007_Chip-Seq_Bcells_Human1.00842836
107OCT4_18692474_ChIP-Seq_MEFs_Mouse1.00642328
108NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.00344915
109SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.99205322
110EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.99112941
111SMC4_20622854_ChIP-Seq_HELA_Human0.98625670
112STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.98495544
113FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.98087593
114ZFX_18555785_ChIP-Seq_MESCs_Mouse0.98057942
115TCF7_22412390_ChIP-Seq_EML_Mouse0.97936659
116CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.97657048
117STAT6_21828071_ChIP-Seq_BEAS2B_Human0.96864598
118SRY_22984422_ChIP-ChIP_TESTIS_Rat0.96518499
119GATA2_19941826_ChIP-Seq_K562_Human0.95679891
120KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.95151469
121P63_26484246_Chip-Seq_KERATINOCYTES_Human0.95075186
122MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.94210808
123DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.94102279
124* CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.93617626
125PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.93232802
126TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.92896871

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle4.48613132
2MP0003705_abnormal_hypodermis_morpholog4.43557377
3MP0005360_urolithiasis4.12057813
4MP0010352_gastrointestinal_tract_polyps3.95190957
5MP0001666_abnormal_nutrient_absorption2.70719855
6MP0003566_abnormal_cell_adhesion2.49874671
7MP0005409_darkened_coat_color2.44783120
8MP0010030_abnormal_orbit_morphology2.43868553
9MP0008438_abnormal_cutaneous_collagen2.36308390
10MP0005275_abnormal_skin_tensile2.36080595
11MP0003300_gastrointestinal_ulcer2.35799293
12MP0000462_abnormal_digestive_system2.34511535
13MP0004264_abnormal_extraembryonic_tissu2.29930122
14MP0009840_abnormal_foam_cell2.21677857
15MP0005257_abnormal_intraocular_pressure2.20973753
16MP0002877_abnormal_melanocyte_morpholog2.19154898
17MP0000537_abnormal_urethra_morphology2.14534934
18MP0002254_reproductive_system_inflammat2.12603656
19MP0004858_abnormal_nervous_system2.11517349
20MP0005451_abnormal_body_composition2.09987140
21MP0002796_impaired_skin_barrier2.03469341
22MP0009053_abnormal_anal_canal1.98175016
23MP0005023_abnormal_wound_healing1.86405167
24MP0000678_abnormal_parathyroid_gland1.84696945
25MP0001849_ear_inflammation1.81667572
26MP0005058_abnormal_lysosome_morphology1.80647411
27MP0003252_abnormal_bile_duct1.77433844
28MP0005623_abnormal_meninges_morphology1.72881273
29MP0005085_abnormal_gallbladder_physiolo1.71388701
30MP0009379_abnormal_foot_pigmentation1.70551341
31MP0003941_abnormal_skin_development1.66536065
32MP0003183_abnormal_peptide_metabolism1.59103702
33MP0003283_abnormal_digestive_organ1.51937969
34MP0002060_abnormal_skin_morphology1.51040179
35MP0002139_abnormal_hepatobiliary_system1.50222209
36MP0004272_abnormal_basement_membrane1.49080889
37MP0010329_abnormal_lipoprotein_level1.43307986
38MP0002735_abnormal_chemical_nociception1.43230626
39MP0000477_abnormal_intestine_morphology1.42434687
40MP0008260_abnormal_autophagy1.41696021
41MP0000467_abnormal_esophagus_morphology1.41113659
42MP0003806_abnormal_nucleotide_metabolis1.40682903
43MP0006054_spinal_hemorrhage1.39399885
44MP0003693_abnormal_embryo_hatching1.37397785
45MP0000538_abnormal_urinary_bladder1.35479884
46MP0000534_abnormal_ureter_morphology1.31865386
47MP0003453_abnormal_keratinocyte_physiol1.31345286
48MP0003866_abnormal_defecation1.30309713
49MP0005501_abnormal_skin_physiology1.25610477
50MP0008007_abnormal_cellular_replicative1.24523792
51MP0005365_abnormal_bile_salt1.19579983
52MP0000858_altered_metastatic_potential1.18993681
53MP0005381_digestive/alimentary_phenotyp1.18363975
54MP0004782_abnormal_surfactant_physiolog1.16067633
55MP0003045_fibrosis1.15147356
56MP0001730_embryonic_growth_arrest1.12971110
57MP0003878_abnormal_ear_physiology1.11815495
58MP0005377_hearing/vestibular/ear_phenot1.11815495
59MP0001663_abnormal_digestive_system1.11579266
60MP0010155_abnormal_intestine_physiology1.11340261
61MP0002736_abnormal_nociception_after1.10556154
62MP0004185_abnormal_adipocyte_glucose1.10552925
63MP0010771_integument_phenotype1.08553952
64MP0009672_abnormal_birth_weight1.07850279
65MP0003091_abnormal_cell_migration1.07069884
66MP0000490_abnormal_crypts_of1.06339808
67MP0002282_abnormal_trachea_morphology1.06150344
68MP0003279_aneurysm1.05838560
69MP0009384_cardiac_valve_regurgitation1.02890912
70MP0001958_emphysema1.02380481
71MP0004947_skin_inflammation1.01018318
72MP0002249_abnormal_larynx_morphology1.00196291
73MP0000762_abnormal_tongue_morphology0.96755493
74MP0008875_abnormal_xenobiotic_pharmacok0.95511861
75* MP0004957_abnormal_blastocyst_morpholog0.95428084
76MP0004233_abnormal_muscle_weight0.95029648
77MP0006138_congestive_heart_failure0.93199325
78MP0003448_altered_tumor_morphology0.92224714
79MP0000751_myopathy0.90819076
80MP0005375_adipose_tissue_phenotype0.90537733
81MP0005076_abnormal_cell_differentiation0.89334473
82MP0001216_abnormal_epidermal_layer0.87726117
83MP0000579_abnormal_nail_morphology0.85271326
84MP0000733_abnormal_muscle_development0.85025236
85MP0005083_abnormal_biliary_tract0.84071556
86MP0002896_abnormal_bone_mineralization0.84070104
87MP0009643_abnormal_urine_homeostasis0.83968454
88MP0009278_abnormal_bone_marrow0.83135760
89MP0000767_abnormal_smooth_muscle0.82944202
90* MP0002086_abnormal_extraembryonic_tissu0.81786594
91MP0000003_abnormal_adipose_tissue0.80994165
92MP0003315_abnormal_perineum_morphology0.80152571
93MP0001243_abnormal_dermal_layer0.79599125
94MP0001664_abnormal_digestion0.78553029
95MP0002998_abnormal_bone_remodeling0.78515917
96MP0008004_abnormal_stomach_pH0.77942659
97MP0005167_abnormal_blood-brain_barrier0.77451973
98MP0003191_abnormal_cellular_cholesterol0.77256741
99MP0000566_synostosis0.77062727
100MP0002111_abnormal_tail_morphology0.76966148
101MP0003943_abnormal_hepatobiliary_system0.76538039
102MP0002098_abnormal_vibrissa_morphology0.75775281
103MP0010368_abnormal_lymphatic_system0.74721019
104MP0001968_abnormal_touch/_nociception0.74402579
105MP0001881_abnormal_mammary_gland0.73490864
106MP0000627_abnormal_mammary_gland0.71910264
107MP0003111_abnormal_nucleus_morphology0.71069609
108MP0005666_abnormal_adipose_tissue0.70779156
109MP0001873_stomach_inflammation0.70554775
110MP0010678_abnormal_skin_adnexa0.70341919
111MP0005621_abnormal_cell_physiology0.68524736
112MP0000609_abnormal_liver_physiology0.67972179
113MP0010307_abnormal_tumor_latency0.67967525
114MP0003329_amyloid_beta_deposits0.67583957
115MP0003984_embryonic_growth_retardation0.65839249
116MP0002084_abnormal_developmental_patter0.64474696
117* MP0002080_prenatal_lethality0.64297922
118MP0004019_abnormal_vitamin_homeostasis0.64252455
119MP0002089_abnormal_postnatal_growth/wei0.64210346
120MP0005380_embryogenesis_phenotype0.63482806
121MP0001672_abnormal_embryogenesis/_devel0.63482806
122MP0005165_increased_susceptibility_to0.63249920
123MP0000432_abnormal_head_morphology0.62883278
124MP0002396_abnormal_hematopoietic_system0.62766774
125MP0001348_abnormal_lacrimal_gland0.62641643
126MP0002136_abnormal_kidney_physiology0.62164096
127MP0002085_abnormal_embryonic_tissue0.62083892
128MP0005166_decreased_susceptibility_to0.62047567
129* MP0009931_abnormal_skin_appearance0.61509785
130MP0005508_abnormal_skeleton_morphology0.61383680
131MP0000598_abnormal_liver_morphology0.60270451
132MP0005367_renal/urinary_system_phenotyp0.60063135
133MP0000516_abnormal_urinary_system0.60063135
134MP0000350_abnormal_cell_proliferation0.59933890
135MP0000377_abnormal_hair_follicle0.59708712
136MP0003115_abnormal_respiratory_system0.59064154

Predicted human phenotypes

RankGene SetZ-score
1Hepatoblastoma (HP:0002884)9.35440841
2Neoplasm of the adrenal cortex (HP:0100641)8.74371018
3Long foot (HP:0001833)7.57292156
4Abnormal pancreas size (HP:0012094)7.50290824
5Diastasis recti (HP:0001540)7.47579888
6Neonatal hypoglycemia (HP:0001998)7.32180317
7Overgrowth (HP:0001548)5.44705325
8High anterior hairline (HP:0009890)5.21455736
9Abnormal glucose tolerance (HP:0001952)4.98127170
10Partial agenesis of the corpus callosum (HP:0001338)4.82883902
11Germ cell neoplasia (HP:0100728)4.65323931
12Neoplasm of the adrenal gland (HP:0100631)4.41718417
13Advanced eruption of teeth (HP:0006288)3.87977203
14Enlarged kidneys (HP:0000105)3.80336674
15Distal lower limb muscle weakness (HP:0009053)3.45987171
16Right ventricular cardiomyopathy (HP:0011663)3.33208470
17Thin bony cortex (HP:0002753)3.21270092
18Hand muscle atrophy (HP:0009130)3.14806289
19Abnormality of the distal phalanges of the toes (HP:0010182)3.03688057
20Flat acetabular roof (HP:0003180)3.02087276
21Ileus (HP:0002595)2.96167035
22Deep philtrum (HP:0002002)2.92357457
23Distal upper limb amyotrophy (HP:0007149)2.88344133
24Upper limb amyotrophy (HP:0009129)2.88344133
25Distal lower limb amyotrophy (HP:0008944)2.82511498
26Hyperacusis (HP:0010780)2.77460242
27Osteolytic defects of the phalanges of the hand (HP:0009771)2.67186645
28Osteolytic defects of the hand bones (HP:0009699)2.67186645
29Broad face (HP:0000283)2.67065657
30Asymmetric growth (HP:0100555)2.66518668
31Large hands (HP:0001176)2.64713029
32Genu varum (HP:0002970)2.64276870
33Acute myeloid leukemia (HP:0004808)2.64020726
34Narrow palate (HP:0000189)2.52017843
35Achilles tendon contracture (HP:0001771)2.50903647
36Vertebral compression fractures (HP:0002953)2.46474833
37Nephroblastoma (Wilms tumor) (HP:0002667)2.45500699
38Atrophic scars (HP:0001075)2.45346352
39Muscle fiber splitting (HP:0003555)2.44654354
40Hypoplastic toenails (HP:0001800)2.43634419
41Cerebral aneurysm (HP:0004944)2.37944603
42Abnormality of the distal phalanx of the thumb (HP:0009617)2.34770880
43Abnormal vertebral ossification (HP:0100569)2.33867452
44Embryonal renal neoplasm (HP:0011794)2.31138015
45Selective tooth agenesis (HP:0001592)2.27367785
46Protrusio acetabuli (HP:0003179)2.25829766
47Ankyloglossia (HP:0010296)2.23662714
48Hyperparathyroidism (HP:0000843)2.23207949
49Abnormality of the Achilles tendon (HP:0005109)2.22232668
50Short nail (HP:0001799)2.21898933
51Cardiomegaly (HP:0001640)2.20256267
52Increased connective tissue (HP:0009025)2.19777784
53Natal tooth (HP:0000695)2.16674273
54Disproportionate tall stature (HP:0001519)2.16002989
55Wormian bones (HP:0002645)2.12474523
56Pili torti (HP:0003777)2.10892718
57Hemorrhage of the eye (HP:0011885)2.10835124
58Stridor (HP:0010307)2.09420350
59Abnormality of oral frenula (HP:0000190)2.07132170
60Spinal rigidity (HP:0003306)2.07008772
61Blue sclerae (HP:0000592)2.04619204
62Limb-girdle muscle atrophy (HP:0003797)2.02790594
63Neonatal short-limb short stature (HP:0008921)2.02208891
64Sandal gap (HP:0001852)2.01835694
65Lower limb amyotrophy (HP:0007210)2.01525074
66Trismus (HP:0000211)2.00645617
67Genu recurvatum (HP:0002816)1.99892978
68Ankle contracture (HP:0006466)1.99406526
69Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.97716621
70Abnormality of glutamine family amino acid metabolism (HP:0010902)1.97415129
71Alopecia of scalp (HP:0002293)1.97238659
72Milia (HP:0001056)1.96701251
73Pointed chin (HP:0000307)1.95131331
74Malnutrition (HP:0004395)1.94727638
75Bladder diverticulum (HP:0000015)1.93537451
76Scapular winging (HP:0003691)1.93409434
77Premature rupture of membranes (HP:0001788)1.92688914
78Wide cranial sutures (HP:0010537)1.92044233
79Hyporeflexia of lower limbs (HP:0002600)1.91500756
80Axonal loss (HP:0003447)1.91328260
81Fragile skin (HP:0001030)1.91290146
82Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.90611071
83Vertebral hypoplasia (HP:0008417)1.90611071
84Focal segmental glomerulosclerosis (HP:0000097)1.89912915
85Diaphragmatic weakness (HP:0009113)1.89686416
86Arterial tortuosity (HP:0005116)1.89128832
87Shallow orbits (HP:0000586)1.88313156
88Fragile nails (HP:0001808)1.86267876
89Mildly elevated creatine phosphokinase (HP:0008180)1.85754916
90Vascular tortuosity (HP:0004948)1.82303326
91Spinal muscular atrophy (HP:0007269)1.80320483
92Bone pain (HP:0002653)1.79381198
93Systemic lupus erythematosus (HP:0002725)1.77929097
94Spinal cord compression (HP:0002176)1.77637514
95Down-sloping shoulders (HP:0200021)1.75290256
96Centrally nucleated skeletal muscle fibers (HP:0003687)1.73537980
97Abnormality of the septum pellucidum (HP:0007375)1.73411435
98Mesangial abnormality (HP:0001966)1.72225331
99Abnormality of nail color (HP:0100643)1.70790626
100Abnormal hair laboratory examination (HP:0003328)1.69722756
101Abnormality of the acetabulum (HP:0003170)1.69672764
102Long palpebral fissure (HP:0000637)1.69638797
103Mitral valve prolapse (HP:0001634)1.69559327
104Neoplasm of the liver (HP:0002896)1.69443008
105Difficulty climbing stairs (HP:0003551)1.68203262
106Pterygium (HP:0001059)1.67981878
107Aortic aneurysm (HP:0004942)1.67467734
108Dilatation of the ascending aorta (HP:0005111)1.67350037
109Asymmetry of the thorax (HP:0001555)1.67283467
110Widely patent fontanelles and sutures (HP:0004492)1.67187492
111Abnormality of the 1st metacarpal (HP:0010009)1.67079522
112Back pain (HP:0003418)1.66928731
113Aplasia of the musculature (HP:0100854)1.66727380
114Myocardial infarction (HP:0001658)1.66438743
115Hydroxyprolinuria (HP:0003080)1.65600019
116Abnormality of proline metabolism (HP:0010907)1.65600019
117Termporal pattern (HP:0011008)1.64853038
118Insidious onset (HP:0003587)1.64853038
119Segmental peripheral demyelination/remyelination (HP:0003481)1.64403693
120Insomnia (HP:0100785)1.63581056
121Tibial bowing (HP:0002982)1.63215551
122Multiple lipomas (HP:0001012)1.61984317
123Ulnar claw (HP:0001178)1.61822771
124Elbow flexion contracture (HP:0002987)1.61126010
125Ulnar bowing (HP:0003031)1.60964257
126Coxa vara (HP:0002812)1.59087771
127Urinary urgency (HP:0000012)1.58854253
128Mitral regurgitation (HP:0001653)1.58810869
129Abnormality of monocarboxylic acid metabolism (HP:0010996)1.58515493
130Joint laxity (HP:0001388)1.57946611
131Peritonitis (HP:0002586)1.55894528
132Cervical subluxation (HP:0003308)1.55377335
133Plantar hyperkeratosis (HP:0007556)1.54954982
134Thick nail (HP:0001805)1.54652603
135Neonatal death (HP:0003811)1.53903818
136Precocious puberty (HP:0000826)1.53874010
137Hypobetalipoproteinemia (HP:0003563)1.53572648
138Broad metatarsal (HP:0001783)1.52882335
139Urethral obstruction (HP:0000796)1.52199563
140Prominent occiput (HP:0000269)1.51592075
141Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.51159768
142Short 1st metacarpal (HP:0010034)1.51159768
143Abnormality of the middle phalanges of the toes (HP:0010183)1.50821272
144Abnormality of complement system (HP:0005339)1.50288465
145Esophageal varix (HP:0002040)1.50079943
146Biconcave vertebral bodies (HP:0004586)1.49932842
147Aortic dissection (HP:0002647)1.49142893
148Abdominal distention (HP:0003270)1.46929387
149Rectal prolapse (HP:0002035)1.46383047
150Foot dorsiflexor weakness (HP:0009027)1.45226890
151Palpitations (HP:0001962)1.45175006
152Aneurysm (HP:0002617)1.44428223
153Bronchomalacia (HP:0002780)1.43253567
154Knee flexion contracture (HP:0006380)1.43200636
155Abnormal ossification of hand bones (HP:0005921)1.41977688
156Woolly hair (HP:0002224)1.41130930
157Gastrointestinal dysmotility (HP:0002579)1.40961779
158Embryonal neoplasm (HP:0002898)1.40177950
159Abnormality of carpal bone ossification (HP:0006257)1.37422403
160Abnormality of the musculature of the hand (HP:0001421)1.37235043
161Missing ribs (HP:0000921)1.36950544

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK15.83021905
2STK165.15026463
3LMTK24.31775268
4SMG13.13149485
5IRAK32.81384324
6EPHA22.50794386
7MKNK22.43229950
8TRIB32.35792354
9MAP3K22.16037672
10FRK2.04054967
11MST1R2.03549887
12PRPF4B2.00526600
13ERN11.98810562
14PKN21.96675798
15MAP2K21.92737793
16TTN1.83779948
17NME21.83237078
18CDK121.80555245
19PAK41.77345523
20SIK11.73671124
21PTK61.72326065
22DDR21.65733916
23EPHB11.65688925
24EEF2K1.62001218
25MAP3K101.56436204
26BRSK21.55624807
27MYLK1.54626717
28FER1.43685412
29MAP3K31.43432932
30EPHA31.39586558
31PRKCI1.36498775
32MATK1.33840644
33MST41.31654269
34ALK1.30612250
35PDGFRA1.28079059
36LRRK21.26312414
37STK101.24758269
38MAP2K11.24652740
39MET1.23133921
40FGFR41.22386950
41MKNK11.21643572
42EPHB21.21630722
43* PRKG21.21018248
44TESK11.16297951
45PTK21.11205328
46MAP3K121.10161964
47LATS21.08524862
48SIK21.08122331
49KSR21.07907960
50BMX0.98158204
51NEK10.97638886
52RPS6KB20.95536186
53NTRK10.94788648
54WEE10.94783242
55TAOK20.91113093
56MAPKAPK30.90519925
57LATS10.90023511
58PRKD20.86248183
59ARAF0.84725577
60PAK20.81086884
61LIMK10.77754140
62HIPK20.75311774
63GRK60.73946532
64ERBB40.72314358
65MAP3K80.70801666
66ICK0.69970585
67TGFBR20.68683719
68RET0.67273388
69PBK0.66306394
70MAP3K60.66101722
71SCYL20.62316966
72CDK70.61802688
73CAMK1G0.61451946
74ROCK10.60182944
75ACVR1B0.60090719
76PDPK10.59806004
77BRAF0.58165065
78CDK60.56538296
79STK240.56519395
80ERBB20.56378612
81MAP3K90.55841817
82MAP3K130.55190502
83MTOR0.54822059
84CAMK1D0.52314123
85PDGFRB0.51674142
86PIK3CA0.50408075
87KDR0.50345352
88MARK30.49585872
89PIM20.47059186
90RPS6KL10.46341612
91RPS6KC10.46341612
92MAP3K140.44332391
93IRAK20.43925939
94MOS0.43797606
95DMPK0.41273460
96FGFR30.41115006
97MAPK110.40710823
98ILK0.39445019
99CDK40.38224064
100TTK0.38151757
101FLT30.37132567
102ABL20.37038935
103RIPK40.36387480
104SRC0.35802898
105MELK0.35630038
106CSNK1E0.35553369
107TBK10.35298833
108TESK20.35106752
109MAP3K10.34758245
110DAPK30.34472126
111MARK20.34445350
112DYRK1B0.33791353
113MAP2K30.33091231
114MAP3K110.32997883
115TAOK10.30960895
116CDC42BPA0.30139950
117ROCK20.29126952
118AKT20.28236212
119CDK90.28075517
120PHKG20.27521764
121PHKG10.27521764
122MAPKAPK20.27311128
123NEK20.27174989
124TYRO30.26788612
125CLK10.25578803
126TRPM70.25457292
127RPS6KA40.25423112
128BRSK10.25229211
129GSK3A0.24367228
130AURKB0.24188298
131PAK10.23479386
132RPS6KA20.22535220
133MINK10.22459358

Predicted pathways (KEGG)

RankGene SetZ-score
1Fat digestion and absorption_Homo sapiens_hsa049753.35790265
2Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049643.14232111
3Mineral absorption_Homo sapiens_hsa049782.94266757
4Renin-angiotensin system_Homo sapiens_hsa046142.94227344
5Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.88731411
6Lysine degradation_Homo sapiens_hsa003102.56848093
7Other glycan degradation_Homo sapiens_hsa005112.30926100
8Protein digestion and absorption_Homo sapiens_hsa049742.23280553
9Nitrogen metabolism_Homo sapiens_hsa009102.20679217
10Carbohydrate digestion and absorption_Homo sapiens_hsa049732.13411798
11Bile secretion_Homo sapiens_hsa049762.12002936
12Caffeine metabolism_Homo sapiens_hsa002322.11053438
13Cyanoamino acid metabolism_Homo sapiens_hsa004601.88436528
14Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.84955533
15Galactose metabolism_Homo sapiens_hsa000521.77353536
16Vitamin digestion and absorption_Homo sapiens_hsa049771.61590969
17Starch and sucrose metabolism_Homo sapiens_hsa005001.52774533
18Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.45775920
19Tight junction_Homo sapiens_hsa045301.44950005
20Thyroid cancer_Homo sapiens_hsa052161.39837586
21Glycerolipid metabolism_Homo sapiens_hsa005611.37197450
22Fructose and mannose metabolism_Homo sapiens_hsa000511.34597881
23Adherens junction_Homo sapiens_hsa045201.34162550
24Bladder cancer_Homo sapiens_hsa052191.32769073
25PPAR signaling pathway_Homo sapiens_hsa033201.32295329
26ECM-receptor interaction_Homo sapiens_hsa045121.30799106
27* Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.29078364
28Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.28396686
292-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.23492684
30Fatty acid degradation_Homo sapiens_hsa000711.23175099
31Arginine biosynthesis_Homo sapiens_hsa002201.19497844
32Leukocyte transendothelial migration_Homo sapiens_hsa046701.18931816
33Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.17825754
34Proteoglycans in cancer_Homo sapiens_hsa052051.17091440
35Histidine metabolism_Homo sapiens_hsa003401.16841568
36Focal adhesion_Homo sapiens_hsa045101.15732544
37Notch signaling pathway_Homo sapiens_hsa043301.15019827
38Tryptophan metabolism_Homo sapiens_hsa003801.14574435
39Prion diseases_Homo sapiens_hsa050201.10209841
40* Amoebiasis_Homo sapiens_hsa051461.08427662
41Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.03303644
42Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.02762438
43Hepatitis C_Homo sapiens_hsa051600.99902339
44Acute myeloid leukemia_Homo sapiens_hsa052210.99763055
45Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.97411244
46Central carbon metabolism in cancer_Homo sapiens_hsa052300.97131373
47Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.96109185
48Pancreatic cancer_Homo sapiens_hsa052120.93636375
49Shigellosis_Homo sapiens_hsa051310.93283790
50Glycosaminoglycan degradation_Homo sapiens_hsa005310.88659636
51Hippo signaling pathway_Homo sapiens_hsa043900.88612377
52Sphingolipid metabolism_Homo sapiens_hsa006000.87384098
53Glutathione metabolism_Homo sapiens_hsa004800.86445457
54Small cell lung cancer_Homo sapiens_hsa052220.85518515
55Pentose and glucuronate interconversions_Homo sapiens_hsa000400.84793846
56Salmonella infection_Homo sapiens_hsa051320.82259341
57Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.80557797
58Insulin resistance_Homo sapiens_hsa049310.80044517
59* AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.78583230
60Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.78066099
61Prostate cancer_Homo sapiens_hsa052150.77674752
62Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.77179396
63Arginine and proline metabolism_Homo sapiens_hsa003300.77137991
64* Thyroid hormone synthesis_Homo sapiens_hsa049180.76290788
65Selenocompound metabolism_Homo sapiens_hsa004500.75667407
66Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.75122190
67MicroRNAs in cancer_Homo sapiens_hsa052060.73214363
68Lysosome_Homo sapiens_hsa041420.69713459
69Carbon metabolism_Homo sapiens_hsa012000.69461683
70Drug metabolism - other enzymes_Homo sapiens_hsa009830.68968329
71Basal cell carcinoma_Homo sapiens_hsa052170.68454547
72Non-small cell lung cancer_Homo sapiens_hsa052230.68322022
73Renal cell carcinoma_Homo sapiens_hsa052110.67092167
74mTOR signaling pathway_Homo sapiens_hsa041500.66862060
75Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.66480790
76* Gastric acid secretion_Homo sapiens_hsa049710.66289656
77N-Glycan biosynthesis_Homo sapiens_hsa005100.65539841
78Vibrio cholerae infection_Homo sapiens_hsa051100.65182076
79Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.64818493
80ErbB signaling pathway_Homo sapiens_hsa040120.64531148
81Sulfur metabolism_Homo sapiens_hsa009200.64160688
82Endometrial cancer_Homo sapiens_hsa052130.63958345
83Biosynthesis of amino acids_Homo sapiens_hsa012300.63350678
84Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.62756465
85Pyruvate metabolism_Homo sapiens_hsa006200.61360850
86Chronic myeloid leukemia_Homo sapiens_hsa052200.59868247
87Toxoplasmosis_Homo sapiens_hsa051450.59838720
88Folate biosynthesis_Homo sapiens_hsa007900.58745485
89Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.57952313
90TNF signaling pathway_Homo sapiens_hsa046680.57250152
91VEGF signaling pathway_Homo sapiens_hsa043700.57105400
92Fatty acid biosynthesis_Homo sapiens_hsa000610.56050131
93Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.55382913
94Regulation of actin cytoskeleton_Homo sapiens_hsa048100.53497529
95Chemical carcinogenesis_Homo sapiens_hsa052040.53032034
96* Pancreatic secretion_Homo sapiens_hsa049720.52534573
97Endocytosis_Homo sapiens_hsa041440.52206732
98Viral myocarditis_Homo sapiens_hsa054160.51107170
99Viral carcinogenesis_Homo sapiens_hsa052030.50983721
100Fatty acid metabolism_Homo sapiens_hsa012120.50340737
101Sulfur relay system_Homo sapiens_hsa041220.49970731
102Glioma_Homo sapiens_hsa052140.47503318
103* Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.45859742
104Maturity onset diabetes of the young_Homo sapiens_hsa049500.45268454
105Hepatitis B_Homo sapiens_hsa051610.43477805
106ABC transporters_Homo sapiens_hsa020100.43294579
107Pentose phosphate pathway_Homo sapiens_hsa000300.43185134
108Adipocytokine signaling pathway_Homo sapiens_hsa049200.41830358
109* Thyroid hormone signaling pathway_Homo sapiens_hsa049190.41430665
110Apoptosis_Homo sapiens_hsa042100.41090153
111Influenza A_Homo sapiens_hsa051640.41038920
112Longevity regulating pathway - mammal_Homo sapiens_hsa042110.40816143
113* GnRH signaling pathway_Homo sapiens_hsa049120.40259582
114Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.40113878
115Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.39603626
116HIF-1 signaling pathway_Homo sapiens_hsa040660.39134448
117Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.38215927
118TGF-beta signaling pathway_Homo sapiens_hsa043500.38184371
119Osteoclast differentiation_Homo sapiens_hsa043800.37388126
120Vitamin B6 metabolism_Homo sapiens_hsa007500.37303005
121AMPK signaling pathway_Homo sapiens_hsa041520.36705051
122* Pathways in cancer_Homo sapiens_hsa052000.36235204
123Insulin signaling pathway_Homo sapiens_hsa049100.36044358
124Pertussis_Homo sapiens_hsa051330.35845305
125Prolactin signaling pathway_Homo sapiens_hsa049170.35166571
126HTLV-I infection_Homo sapiens_hsa051660.35025167
127Complement and coagulation cascades_Homo sapiens_hsa046100.34885970
128PI3K-Akt signaling pathway_Homo sapiens_hsa041510.34571974
129Neurotrophin signaling pathway_Homo sapiens_hsa047220.34303476
130* Rap1 signaling pathway_Homo sapiens_hsa040150.33428295
131Type II diabetes mellitus_Homo sapiens_hsa049300.33186749
132Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.33143651

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