PLCB4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of many extracellular signals in the retina. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1phenol-containing compound catabolic process (GO:0019336)8.82292581
2dopamine biosynthetic process (GO:0042416)6.31357655
3neurotransmitter catabolic process (GO:0042135)5.67012711
4catecholamine transport (GO:0051937)5.54589061
5dopamine transport (GO:0015872)5.34231003
6catechol-containing compound biosynthetic process (GO:0009713)5.10527025
7catecholamine biosynthetic process (GO:0042423)5.10527025
8behavioral response to nicotine (GO:0035095)5.04890893
9neuron cell-cell adhesion (GO:0007158)4.73512992
10alkaloid metabolic process (GO:0009820)4.66916271
11mating behavior (GO:0007617)4.65724406
12dopamine metabolic process (GO:0042417)4.64429830
13behavioral response to ethanol (GO:0048149)4.61181453
14positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.56187686
15positive regulation of potassium ion transmembrane transporter activity (GO:1901018)4.47656086
16regulation of short-term neuronal synaptic plasticity (GO:0048172)4.46379252
17synaptic vesicle exocytosis (GO:0016079)4.44652830
18vocalization behavior (GO:0071625)4.27228993
19neurotransmitter biosynthetic process (GO:0042136)4.23337177
20regulation of dopamine metabolic process (GO:0042053)4.20008955
21regulation of catecholamine metabolic process (GO:0042069)4.20008955
22neurotransmitter secretion (GO:0007269)4.09808484
23synaptic transmission, cholinergic (GO:0007271)4.00489332
24mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.95684773
25mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.91364413
26positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.86449205
27neurotransmitter transport (GO:0006836)3.85025264
28negative regulation of microtubule polymerization (GO:0031115)3.70873427
29regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.68497072
30glutamate secretion (GO:0014047)3.66685756
31ATP synthesis coupled proton transport (GO:0015986)3.66216913
32energy coupled proton transport, down electrochemical gradient (GO:0015985)3.66216913
33regulation of neurotransmitter levels (GO:0001505)3.65164531
34proline transport (GO:0015824)3.59537140
35negative regulation of hormone biosynthetic process (GO:0032353)3.57999377
36sympathetic nervous system development (GO:0048485)3.57592793
37cerebellar Purkinje cell differentiation (GO:0021702)3.54037018
38regulation of synaptic vesicle exocytosis (GO:2000300)3.51612306
39neurotransmitter metabolic process (GO:0042133)3.51507193
40response to insecticide (GO:0017085)3.50739748
41regulation of vesicle fusion (GO:0031338)3.50120575
42synaptic vesicle docking involved in exocytosis (GO:0016081)3.42738252
43prepulse inhibition (GO:0060134)3.41160700
44neuromuscular synaptic transmission (GO:0007274)3.38894951
45gamma-aminobutyric acid signaling pathway (GO:0007214)3.37897210
46neuronal action potential propagation (GO:0019227)3.37050434
47regulation of type B pancreatic cell apoptotic process (GO:2000674)3.35553391
48regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)3.30351247
49regulation of dopamine uptake involved in synaptic transmission (GO:0051584)3.30351247
50monoamine transport (GO:0015844)3.28455929
51catecholamine metabolic process (GO:0006584)3.24786470
52catechol-containing compound metabolic process (GO:0009712)3.24786470
53electron transport chain (GO:0022900)3.24159881
54neuron recognition (GO:0008038)3.23817561
55detection of calcium ion (GO:0005513)3.23042544
56regulation of protein kinase A signaling (GO:0010738)3.22313558
57phenol-containing compound biosynthetic process (GO:0046189)3.20981925
58response to amphetamine (GO:0001975)3.20847536
59cell differentiation in hindbrain (GO:0021533)3.20610178
60respiratory electron transport chain (GO:0022904)3.19569127
61positive regulation of potassium ion transmembrane transport (GO:1901381)3.18588844
62neuron-neuron synaptic transmission (GO:0007270)3.17212746
63synaptic transmission, dopaminergic (GO:0001963)3.17028885
64response to cocaine (GO:0042220)3.16138430
65protein localization to synapse (GO:0035418)3.14360880
66regulation of neurotransmitter transport (GO:0051588)3.11471986
67synaptic vesicle maturation (GO:0016188)3.10232180
68regulation of glutamate receptor signaling pathway (GO:1900449)3.09052017
69regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.08091251
70regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.07919571
71regulation of neurotransmitter secretion (GO:0046928)3.07492524
72negative regulation of hormone metabolic process (GO:0032351)3.06164745
73membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.04938490
74regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.04535366
75ATP hydrolysis coupled proton transport (GO:0015991)3.04407563
76energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.04407563
77glutamate receptor signaling pathway (GO:0007215)3.04340784
78maternal behavior (GO:0042711)3.04289666
79negative regulation of neurotransmitter transport (GO:0051589)3.04035435
80locomotory exploration behavior (GO:0035641)3.03835918
81response to histamine (GO:0034776)3.01631777
82regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.01225209
83regulation of synaptic vesicle transport (GO:1902803)3.00670357
84norepinephrine metabolic process (GO:0042415)3.00576146
85synapse assembly (GO:0007416)2.99788938
86cerebellar granule cell differentiation (GO:0021707)2.99151887
87regulation of dopamine secretion (GO:0014059)2.97710387
88ionotropic glutamate receptor signaling pathway (GO:0035235)2.95891569
89axonal fasciculation (GO:0007413)2.93598279
90behavioral response to cocaine (GO:0048148)2.93544227
91establishment of protein localization to mitochondrial membrane (GO:0090151)2.92919402
92toxin metabolic process (GO:0009404)2.92847204
93positive regulation of synapse assembly (GO:0051965)2.92464099
94striatum development (GO:0021756)2.91851674
95regulation of synapse structural plasticity (GO:0051823)2.91518850
96G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.91025038
97regulation of respiratory gaseous exchange (GO:0043576)2.90983061
98positive regulation of neurotransmitter transport (GO:0051590)2.90744424
99positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.90459001
100regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.89702051
101neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.89280940
102neuron remodeling (GO:0016322)2.89260835
103layer formation in cerebral cortex (GO:0021819)2.88978005
104transmission of nerve impulse (GO:0019226)2.88901768
105regulation of cell communication by electrical coupling (GO:0010649)2.88677686
106inner ear receptor cell development (GO:0060119)2.86531088
107negative regulation of cytosolic calcium ion concentration (GO:0051481)2.76962811
108positive regulation of protein autophosphorylation (GO:0031954)2.71261932
109dendritic spine morphogenesis (GO:0060997)2.70210257
110regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.54435954
111sequestering of extracellular ligand from receptor (GO:0035581)2.52680446
112urinary tract smooth muscle contraction (GO:0014848)2.51774626
113cellular potassium ion homeostasis (GO:0030007)2.49564224
114negative regulation of axon extension involved in axon guidance (GO:0048843)2.46942515
115regulation of axon extension involved in axon guidance (GO:0048841)2.44494649
116auditory behavior (GO:0031223)2.37747139
117presynaptic membrane organization (GO:0097090)2.32780823
118kidney mesenchyme development (GO:0072074)2.30796369
119endocardial cushion development (GO:0003197)2.27936077
120apical protein localization (GO:0045176)2.27270580
121chemosensory behavior (GO:0007635)2.25343141
122regulation of axon guidance (GO:1902667)2.24260125
123smooth muscle tissue development (GO:0048745)2.24117258
124regulation of synapse assembly (GO:0051963)2.21397346
125cilium movement (GO:0003341)2.21023294
126metanephric mesenchyme development (GO:0072075)2.20447678
127regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.17607109
128cellular response to vitamin D (GO:0071305)2.17472194
129positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.15816935
130negative regulation of axon guidance (GO:1902668)2.15225912
131embryonic retina morphogenesis in camera-type eye (GO:0060059)2.15173863
132neuronal action potential (GO:0019228)2.15005326
133righting reflex (GO:0060013)2.13958329
134epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.13355159
135presynaptic membrane assembly (GO:0097105)2.12851680
136myoblast fusion (GO:0007520)2.12656960
137negative regulation of synaptic transmission, GABAergic (GO:0032229)2.11584157
138innervation (GO:0060384)2.11149986
139cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.11000467
140insulin secretion (GO:0030073)2.10781517
141response to gravity (GO:0009629)2.09051465
142negative regulation of dendrite development (GO:2000171)2.08704636
143membrane depolarization during action potential (GO:0086010)2.07994723
144epithelial cilium movement (GO:0003351)2.06858446
145metanephric tubule development (GO:0072170)2.05706272
146metanephric nephron tubule development (GO:0072234)2.05706272
147auditory receptor cell differentiation (GO:0042491)2.05479821
148multicellular organismal signaling (GO:0035637)2.04839970
149artery development (GO:0060840)2.03436077
150cardiac conduction (GO:0061337)2.03080681
151regulation of heart rate by cardiac conduction (GO:0086091)2.01961417
152cellular response to vitamin (GO:0071295)2.00952525
153cranial nerve morphogenesis (GO:0021602)2.00570917
154negative regulation of dendrite morphogenesis (GO:0050774)2.00033348
155regulation of long-term neuronal synaptic plasticity (GO:0048169)1.98562176
156retina layer formation (GO:0010842)1.97680186
157negative regulation of gluconeogenesis (GO:0045721)1.96224555
158axonemal dynein complex assembly (GO:0070286)1.96127224
159potassium ion homeostasis (GO:0055075)1.94934661
160actin filament depolymerization (GO:0030042)1.94930131
161left/right pattern formation (GO:0060972)1.94763419
162gamma-aminobutyric acid transport (GO:0015812)1.94745804
163action potential (GO:0001508)1.94472611
164establishment of protein localization to Golgi (GO:0072600)1.94376057
165calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)1.94368415
166regulation of action potential (GO:0098900)1.93146435
167retrograde transport, vesicle recycling within Golgi (GO:0000301)1.92766611
168synaptic transmission, glutamatergic (GO:0035249)1.92523423
169regulation of neuronal synaptic plasticity (GO:0048168)1.92156048
170tonic smooth muscle contraction (GO:0014820)1.92030555
171negative regulation of neurotransmitter secretion (GO:0046929)1.91930485
172regulation of respiratory system process (GO:0044065)1.91715754
173regulation of calcium ion-dependent exocytosis (GO:0017158)1.91061961
174cell communication involved in cardiac conduction (GO:0086065)1.91036219
175protein targeting to Golgi (GO:0000042)1.90992852
176vascular smooth muscle contraction (GO:0014829)1.90433370

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.94596422
2GBX2_23144817_ChIP-Seq_PC3_Human3.61971561
3TAF15_26573619_Chip-Seq_HEK293_Human3.29606949
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.08890835
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.08115671
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.73201704
7SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.58149810
8SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.53142215
9EZH2_18974828_ChIP-Seq_MESCs_Mouse2.51139298
10RNF2_18974828_ChIP-Seq_MESCs_Mouse2.51139298
11SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.42563664
12JARID2_20075857_ChIP-Seq_MESCs_Mouse2.41328688
13EZH2_27304074_Chip-Seq_ESCs_Mouse2.38980334
14MTF2_20144788_ChIP-Seq_MESCs_Mouse2.32163010
15REST_21632747_ChIP-Seq_MESCs_Mouse2.30630025
16SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.23318429
17NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.21130490
18EED_16625203_ChIP-ChIP_MESCs_Mouse2.19701056
19CTBP2_25329375_ChIP-Seq_LNCAP_Human2.19637168
20ZFP57_27257070_Chip-Seq_ESCs_Mouse2.11906134
21* CTBP1_25329375_ChIP-Seq_LNCAP_Human2.08403528
22BMI1_23680149_ChIP-Seq_NPCS_Mouse2.08089263
23* NR3C1_23031785_ChIP-Seq_PC12_Mouse2.00735650
24GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.00053703
25CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.96206880
26IKZF1_21737484_ChIP-ChIP_HCT116_Human1.94849664
27SUZ12_27294783_Chip-Seq_ESCs_Mouse1.92761804
28GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.91953793
29FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.87526043
30EZH2_27294783_Chip-Seq_ESCs_Mouse1.85084972
31DROSHA_22980978_ChIP-Seq_HELA_Human1.85074290
32RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.83294302
33P300_19829295_ChIP-Seq_ESCs_Human1.83127624
34RNF2_27304074_Chip-Seq_ESCs_Mouse1.81651821
35REST_18959480_ChIP-ChIP_MESCs_Mouse1.81067010
36PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.80096370
37TRIM28_21343339_ChIP-Seq_HEK293_Human1.79466325
38PIAS1_25552417_ChIP-Seq_VCAP_Human1.79328592
39* SMAD4_21799915_ChIP-Seq_A2780_Human1.78261849
40CDX2_19796622_ChIP-Seq_MESCs_Mouse1.77448296
41* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.72821769
42FUS_26573619_Chip-Seq_HEK293_Human1.70966690
43ZNF274_21170338_ChIP-Seq_K562_Hela1.68671222
44IGF1R_20145208_ChIP-Seq_DFB_Human1.67824090
45AR_21572438_ChIP-Seq_LNCaP_Human1.62867077
46SMAD_19615063_ChIP-ChIP_OVARY_Human1.56228080
47* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.53801400
48RBPJ_22232070_ChIP-Seq_NCS_Mouse1.48658640
49PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.48289944
50* SMAD3_21741376_ChIP-Seq_EPCs_Human1.47031429
51* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.44040164
52UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.43865581
53CBX2_27304074_Chip-Seq_ESCs_Mouse1.42974925
54AR_25329375_ChIP-Seq_VCAP_Human1.42511610
55* BCAT_22108803_ChIP-Seq_LS180_Human1.42090474
56ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.41351341
57VDR_22108803_ChIP-Seq_LS180_Human1.37287643
58RARB_27405468_Chip-Seq_BRAIN_Mouse1.37121439
59SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.37075536
60* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.36730002
61* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.36484789
62SALL1_21062744_ChIP-ChIP_HESCs_Human1.35886521
63* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.33452330
64* SOX2_21211035_ChIP-Seq_LN229_Gbm1.31947713
65ERG_21242973_ChIP-ChIP_JURKAT_Human1.30321221
66* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.27531704
67RNF2_27304074_Chip-Seq_NSC_Mouse1.26710195
68NRF2_20460467_ChIP-Seq_MEFs_Mouse1.26324403
69NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.26324403
70ER_23166858_ChIP-Seq_MCF-7_Human1.25341764
71* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.24593043
72TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.23933760
73RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.23928082
74ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.23749700
75STAT3_23295773_ChIP-Seq_U87_Human1.23571485
76* RUNX2_22187159_ChIP-Seq_PCA_Human1.20678236
77BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.18944482
78ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.18554840
79FLI1_27457419_Chip-Seq_LIVER_Mouse1.18071706
80* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.17468468
81EP300_21415370_ChIP-Seq_HL-1_Mouse1.14336145
82CTNNB1_20460455_ChIP-Seq_HCT116_Human1.13698229
83* CJUN_26792858_Chip-Seq_BT549_Human1.11418209
84* TCF4_23295773_ChIP-Seq_U87_Human1.09992342
85SMAD3_21741376_ChIP-Seq_HESCs_Human1.09968680
86JUN_21703547_ChIP-Seq_K562_Human1.08057708
87MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.08029293
88TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.07510490
89PRDM14_20953172_ChIP-Seq_ESCs_Human1.07025451
90MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.06785462
91CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.06661398
92* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.06496613
93ESR1_20079471_ChIP-ChIP_T-47D_Human1.05747896
94BRD4_25478319_ChIP-Seq_HGPS_Human1.05399364
95* TCF4_22108803_ChIP-Seq_LS180_Human1.04222820
96LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04153542
97* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.03551940
98WT1_19549856_ChIP-ChIP_CCG9911_Human1.03160013
99* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.02656224
100RING1B_27294783_Chip-Seq_ESCs_Mouse1.02430856
101TP53_18474530_ChIP-ChIP_U2OS_Human1.01892474
102* NANOG_18555785_Chip-Seq_ESCs_Mouse1.01555889
103TP53_16413492_ChIP-PET_HCT116_Human1.01364677
104PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.99540890
105TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98822342
106AR_19668381_ChIP-Seq_PC3_Human0.96973120
107YAP1_20516196_ChIP-Seq_MESCs_Mouse0.94484094
108* EWS_26573619_Chip-Seq_HEK293_Human0.93022863
109MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.91686538
110CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.91401876
111IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.90896941
112CBP_20019798_ChIP-Seq_JUKART_Human0.90896941
113KLF5_20875108_ChIP-Seq_MESCs_Mouse0.90599915
114* CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89475328
115P53_22127205_ChIP-Seq_FIBROBLAST_Human0.89381035
116STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.89253699
117ARNT_22903824_ChIP-Seq_MCF-7_Human0.88959172
118* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.87909434
119AHR_22903824_ChIP-Seq_MCF-7_Human0.87730080
120FLI1_21867929_ChIP-Seq_TH2_Mouse0.87661733

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002822_catalepsy5.38917735
2MP0003880_abnormal_central_pattern4.01718949
3MP0001905_abnormal_dopamine_level3.35445773
4MP0006276_abnormal_autonomic_nervous3.33460359
5MP0009046_muscle_twitch3.25386559
6MP0001529_abnormal_vocalization3.23587098
7* MP0003635_abnormal_synaptic_transmissio3.07248931
8MP0004859_abnormal_synaptic_plasticity3.04052977
9MP0009745_abnormal_behavioral_response3.03225798
10MP0010386_abnormal_urinary_bladder2.95951705
11MP0003283_abnormal_digestive_organ2.89118903
12MP0002064_seizures2.72759075
13MP0001501_abnormal_sleep_pattern2.70223254
14MP0004270_analgesia2.67369282
15MP0001440_abnormal_grooming_behavior2.66149283
16MP0002734_abnormal_mechanical_nocicepti2.54766597
17MP0002572_abnormal_emotion/affect_behav2.43355067
18MP0002638_abnormal_pupillary_reflex2.42132744
19MP0004924_abnormal_behavior2.38692176
20MP0005386_behavior/neurological_phenoty2.38692176
21MP0002272_abnormal_nervous_system2.35326787
22MP0002063_abnormal_learning/memory/cond2.32399910
23MP0001968_abnormal_touch/_nociception2.30802714
24MP0005423_abnormal_somatic_nervous2.28348506
25MP0002733_abnormal_thermal_nociception2.19520151
26MP0002837_dystrophic_cardiac_calcinosis2.18470993
27MP0001970_abnormal_pain_threshold2.10225086
28MP0002067_abnormal_sensory_capabilities2.04293896
29MP0003122_maternal_imprinting1.87613670
30MP0001486_abnormal_startle_reflex1.87008859
31MP0003123_paternal_imprinting1.81811444
32MP0008872_abnormal_physiological_respon1.80243597
33MP0001188_hyperpigmentation1.77301664
34MP0002735_abnormal_chemical_nociception1.71742685
35MP0002557_abnormal_social/conspecific_i1.66841240
36MP0008569_lethality_at_weaning1.65477901
37MP0002736_abnormal_nociception_after1.63721577
38* MP0002184_abnormal_innervation1.61640078
39MP0001984_abnormal_olfaction1.58228310
40MP0000751_myopathy1.51426935
41MP0008438_abnormal_cutaneous_collagen1.50112355
42MP0002909_abnormal_adrenal_gland1.48940691
43MP0005646_abnormal_pituitary_gland1.48141260
44MP0000538_abnormal_urinary_bladder1.45434782
45MP0000778_abnormal_nervous_system1.40043568
46MP0004142_abnormal_muscle_tone1.38244002
47MP0000534_abnormal_ureter_morphology1.34434107
48MP0005409_darkened_coat_color1.34300433
49MP0000462_abnormal_digestive_system1.32968366
50MP0005503_abnormal_tendon_morphology1.32719224
51MP0004145_abnormal_muscle_electrophysio1.31115867
52MP0002102_abnormal_ear_morphology1.28589525
53MP0003942_abnormal_urinary_system1.26389678
54MP0004858_abnormal_nervous_system1.25350366
55MP0004133_heterotaxia1.25030944
56MP0009379_abnormal_foot_pigmentation1.21536690
57* MP0002066_abnormal_motor_capabilities/c1.20832542
58MP0005535_abnormal_body_temperature1.18070041
59MP0004215_abnormal_myocardial_fiber1.17528921
60MP0000013_abnormal_adipose_tissue1.17049052
61MP0003950_abnormal_plasma_membrane1.16899825
62MP0000955_abnormal_spinal_cord1.16517803
63MP0009384_cardiac_valve_regurgitation1.16002015
64MP0005645_abnormal_hypothalamus_physiol1.14794956
65MP0004043_abnormal_pH_regulation1.14327290
66MP0002234_abnormal_pharynx_morphology1.12989044
67MP0000427_abnormal_hair_cycle1.12975855
68MP0010234_abnormal_vibrissa_follicle1.12711012
69MP0002751_abnormal_autonomic_nervous1.12291173
70MP0002882_abnormal_neuron_morphology1.11144092
71MP0003279_aneurysm1.11082385
72MP0006072_abnormal_retinal_apoptosis1.10286144
73MP0001502_abnormal_circadian_rhythm1.10255992
74MP0000569_abnormal_digit_pigmentation1.09709434
75MP0001485_abnormal_pinna_reflex1.08926724
76MP0003937_abnormal_limbs/digits/tail_de1.07564312
77MP0002332_abnormal_exercise_endurance1.05443706
78MP0002160_abnormal_reproductive_system1.04515688
79MP0004134_abnormal_chest_morphology1.04371077
80MP0004811_abnormal_neuron_physiology1.04206158
81MP0005499_abnormal_olfactory_system1.01869605
82MP0005394_taste/olfaction_phenotype1.01869605
83MP0004742_abnormal_vestibular_system1.00086887
84MP0004085_abnormal_heartbeat0.99456622
85MP0008877_abnormal_DNA_methylation0.98674948
86MP0005379_endocrine/exocrine_gland_phen0.98279830
87MP0002108_abnormal_muscle_morphology0.97751608
88MP0003329_amyloid_beta_deposits0.97732105
89MP0001944_abnormal_pancreas_morphology0.96604347
90MP0003890_abnormal_embryonic-extraembry0.96354575
91* MP0005551_abnormal_eye_electrophysiolog0.96127686
92MP0000631_abnormal_neuroendocrine_gland0.95310512
93MP0002938_white_spotting0.95107775
94MP0008775_abnormal_heart_ventricle0.95037820
95MP0008874_decreased_physiological_sensi0.93929378
96MP0009250_abnormal_appendicular_skeleto0.93425151
97* MP0003633_abnormal_nervous_system0.93336393
98MP0004885_abnormal_endolymph0.92849753
99* MP0003631_nervous_system_phenotype0.92490238
100MP0003121_genomic_imprinting0.89541766
101MP0002229_neurodegeneration0.88610371
102MP0003385_abnormal_body_wall0.88305163
103MP0003755_abnormal_palate_morphology0.86317637
104MP0002163_abnormal_gland_morphology0.85026642
105MP0002876_abnormal_thyroid_physiology0.84872885
106MP0003195_calcinosis0.84837263
107* MP0002152_abnormal_brain_morphology0.83970751
108MP0000003_abnormal_adipose_tissue0.82381779
109MP0005257_abnormal_intraocular_pressure0.82053713
110MP0001664_abnormal_digestion0.81708429
111MP0003632_abnormal_nervous_system0.80071434
112MP0002896_abnormal_bone_mineralization0.78471021
113MP0002752_abnormal_somatic_nervous0.77621022
114MP0002069_abnormal_eating/drinking_beha0.77405149
115MP0000372_irregular_coat_pigmentation0.77112317
116MP0004036_abnormal_muscle_relaxation0.76321493
117MP0000747_muscle_weakness0.75640205
118MP0005171_absent_coat_pigmentation0.74937213
119MP0003879_abnormal_hair_cell0.74696130
120MP0004484_altered_response_of0.73777591
121MP0005623_abnormal_meninges_morphology0.72913034
122MP0003941_abnormal_skin_development0.72780629
123MP0002233_abnormal_nose_morphology0.72703087
124MP0002127_abnormal_cardiovascular_syste0.72049029
125MP0003119_abnormal_digestive_system0.71398339
126MP0005275_abnormal_skin_tensile0.71207781
127MP0001943_abnormal_respiration0.69525385
128MP0008789_abnormal_olfactory_epithelium0.66270771
129MP0006035_abnormal_mitochondrial_morpho0.65912638
130MP0001963_abnormal_hearing_physiology0.64035053
131MP0005187_abnormal_penis_morphology0.63575605
132MP0009780_abnormal_chondrocyte_physiolo0.63013117
133MP0003137_abnormal_impulse_conducting0.62942824
134MP0001299_abnormal_eye_distance/0.60287468
135MP0005620_abnormal_muscle_contractility0.59145917
136MP0005253_abnormal_eye_physiology0.56259477
137MP0003634_abnormal_glial_cell0.53572522
138MP0004272_abnormal_basement_membrane0.53562663
139MP0003787_abnormal_imprinting0.49610775
140MP0004084_abnormal_cardiac_muscle0.48430069

Predicted human phenotypes

RankGene SetZ-score
1Hypothermia (HP:0002045)8.00056022
2Limb dystonia (HP:0002451)7.23755289
3Focal motor seizures (HP:0011153)5.59309173
4Myokymia (HP:0002411)5.00010654
5Progressive cerebellar ataxia (HP:0002073)4.81112755
6Visual hallucinations (HP:0002367)4.55947892
7Focal seizures (HP:0007359)4.53825494
8Atonic seizures (HP:0010819)4.44723248
9Orthostatic hypotension (HP:0001278)3.99831897
10Pheochromocytoma (HP:0002666)3.85975896
11Acute necrotizing encephalopathy (HP:0006965)3.78905429
12Febrile seizures (HP:0002373)3.62669078
13Absence seizures (HP:0002121)3.59910049
14Progressive macrocephaly (HP:0004481)3.48085843
15Abnormal mitochondria in muscle tissue (HP:0008316)3.44255293
16Neuroendocrine neoplasm (HP:0100634)3.43076316
17Abnormal pupillary function (HP:0007686)3.31810633
18Abnormal autonomic nervous system physiology (HP:0012332)3.29482557
19Action tremor (HP:0002345)3.23231174
20Generalized tonic-clonic seizures (HP:0002069)3.19475402
21Epileptic encephalopathy (HP:0200134)3.18042777
22Dialeptic seizures (HP:0011146)3.17689330
23Amblyopia (HP:0000646)3.16583670
24Mitochondrial inheritance (HP:0001427)3.11942217
25Hypoventilation (HP:0002791)2.98257079
26Anxiety (HP:0000739)2.96336472
27Broad-based gait (HP:0002136)2.93620646
28Acute encephalopathy (HP:0006846)2.82508785
29Exotropia (HP:0000577)2.81333311
30Postural tremor (HP:0002174)2.79027502
31Gaze-evoked nystagmus (HP:0000640)2.73009892
32Truncal ataxia (HP:0002078)2.68248573
33Dysdiadochokinesis (HP:0002075)2.64987219
34Myotonia (HP:0002486)2.62253048
35Failure to thrive in infancy (HP:0001531)2.61793856
36Agitation (HP:0000713)2.59417999
37Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.57243517
38Hypoplastic ischia (HP:0003175)2.51703927
39Hyperinsulinemic hypoglycemia (HP:0000825)2.50532251
40Broad metatarsal (HP:0001783)2.50294047
41Optic disc pallor (HP:0000543)2.42447200
42Cerebral hemorrhage (HP:0001342)2.41338246
43Dysmetria (HP:0001310)2.38942555
44Overgrowth (HP:0001548)2.37073138
45Increased CSF lactate (HP:0002490)2.34137048
46Pancreatic fibrosis (HP:0100732)2.33648379
47Abnormal pancreas size (HP:0012094)2.33259591
48Progressive inability to walk (HP:0002505)2.32869335
49Genital tract atresia (HP:0001827)2.32417627
50Morphological abnormality of the pyramidal tract (HP:0002062)2.32256811
51Cerebral inclusion bodies (HP:0100314)2.31873985
52Abnormality of the corticospinal tract (HP:0002492)2.30738725
53Neonatal hypoglycemia (HP:0001998)2.30173948
54Hyperthyroidism (HP:0000836)2.26507335
55Popliteal pterygium (HP:0009756)2.22089864
56Abnormality of the ischium (HP:0003174)2.20624108
57Termporal pattern (HP:0011008)2.19921771
58Insidious onset (HP:0003587)2.19921771
59Hyperventilation (HP:0002883)2.19269427
60Depression (HP:0000716)2.18945051
61Medial flaring of the eyebrow (HP:0010747)2.18628641
62Hypsarrhythmia (HP:0002521)2.16168279
63Facial shape deformation (HP:0011334)2.15753156
64Potter facies (HP:0002009)2.15753156
65Hypoglycemic seizures (HP:0002173)2.13890021
66Hemiparesis (HP:0001269)2.13579260
67Poor eye contact (HP:0000817)2.12343221
68Akinesia (HP:0002304)2.11775138
69Horizontal nystagmus (HP:0000666)2.11506684
70Gait imbalance (HP:0002141)2.11418587
71Increased hepatocellular lipid droplets (HP:0006565)2.11164381
72Vaginal atresia (HP:0000148)2.08578211
73Hypotension (HP:0002615)2.08299715
74Nephronophthisis (HP:0000090)2.07090094
75Delayed gross motor development (HP:0002194)2.05855290
76Scanning speech (HP:0002168)2.05698568
77Hepatocellular necrosis (HP:0001404)2.04359646
78Supranuclear gaze palsy (HP:0000605)2.00589041
79Aortic aneurysm (HP:0004942)1.99218303
80Bundle branch block (HP:0011710)1.98515475
81Calf muscle hypertrophy (HP:0008981)1.95948955
82Polyphagia (HP:0002591)1.94295372
83Abnormal social behavior (HP:0012433)1.93109107
84Impaired social interactions (HP:0000735)1.93109107
85EEG with generalized epileptiform discharges (HP:0011198)1.92405285
86Abnormality of calcium-phosphate metabolism (HP:0100530)1.92363541
87Hypoglycemic coma (HP:0001325)1.92126006
88Muscle hypertrophy of the lower extremities (HP:0008968)1.91934313
89Papilledema (HP:0001085)1.90563069
90Epileptiform EEG discharges (HP:0011182)1.90486128
91Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.90141545
92Degeneration of the lateral corticospinal tracts (HP:0002314)1.90141545
93Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.89532334
94Syncope (HP:0001279)1.89125458
95Bradykinesia (HP:0002067)1.89083017
96Psychosis (HP:0000709)1.88224042
97Aortic dissection (HP:0002647)1.86976704
98Genetic anticipation (HP:0003743)1.86304959
99Abnormal eating behavior (HP:0100738)1.85778787
100Hyperphosphatemia (HP:0002905)1.85640997
101Gait ataxia (HP:0002066)1.85420536
102Sudden death (HP:0001699)1.83665718
103Abnormality of the renal medulla (HP:0100957)1.83664489
104Autoamputation (HP:0001218)1.83648112
105Prolonged QT interval (HP:0001657)1.83548612
106Congenital primary aphakia (HP:0007707)1.83386894
107Abnormal ciliary motility (HP:0012262)1.82465848
108Cerebral edema (HP:0002181)1.82304880
109Diplopia (HP:0000651)1.81801164
110Abnormality of binocular vision (HP:0011514)1.81801164
111Emotional lability (HP:0000712)1.80840065
112Drooling (HP:0002307)1.80403361
113Excessive salivation (HP:0003781)1.80403361
114Impaired vibration sensation in the lower limbs (HP:0002166)1.80005997
115Left ventricular hypertrophy (HP:0001712)1.79963448
116Renal Fanconi syndrome (HP:0001994)1.79573506
117Fetal akinesia sequence (HP:0001989)1.78556653
118Nephrogenic diabetes insipidus (HP:0009806)1.78495932
119Esotropia (HP:0000565)1.78086207
120Bradycardia (HP:0001662)1.77853005
121Impaired smooth pursuit (HP:0007772)1.77318860
122Abnormality of ocular smooth pursuit (HP:0000617)1.76912795
123Retinal dysplasia (HP:0007973)1.76813674
124X-linked dominant inheritance (HP:0001423)1.76463118
125Enlarged penis (HP:0000040)1.76084267
126Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.76023409
127Rigidity (HP:0002063)1.75616157
128Ketoacidosis (HP:0001993)1.74034513
129True hermaphroditism (HP:0010459)1.72580107
130Abnormality of midbrain morphology (HP:0002418)1.72438195
131Molar tooth sign on MRI (HP:0002419)1.72438195
132Abnormality of the calf musculature (HP:0001430)1.72070071
133Abnormal respiratory motile cilium physiology (HP:0012261)1.71472845
134Tubular atrophy (HP:0000092)1.70668294
135Premature rupture of membranes (HP:0001788)1.70195460
136Metaphyseal dysplasia (HP:0100255)1.68620913
137Shawl scrotum (HP:0000049)1.68015042
138Large for gestational age (HP:0001520)1.67752571
139Hepatoblastoma (HP:0002884)1.67613509
140Neoplasm of the adrenal cortex (HP:0100641)1.65437127
141Cystic liver disease (HP:0006706)1.64547794
142Pancreatic cysts (HP:0001737)1.62939358
143Poor coordination (HP:0002370)1.62013356
144Increased number of teeth (HP:0011069)1.61904584
145Coronal craniosynostosis (HP:0004440)1.59909876
146Hyperglycemia (HP:0003074)1.59413350
147Occipital encephalocele (HP:0002085)1.59292272
148Rhinitis (HP:0012384)1.59205056
149Atrial fibrillation (HP:0005110)1.58328260
150Macroorchidism (HP:0000053)1.58060439
151Pulmonic stenosis (HP:0001642)1.57268918
152Limited hip movement (HP:0008800)1.56914245
153Abnormality of dentin (HP:0010299)1.56608793
154Congenital glaucoma (HP:0001087)1.56534789
155Buphthalmos (HP:0000557)1.55603405
156Disproportionate short-trunk short stature (HP:0003521)1.55256619
157Aqueductal stenosis (HP:0002410)1.55026821
158Dynein arm defect of respiratory motile cilia (HP:0012255)1.54607558
159Absent/shortened dynein arms (HP:0200106)1.54607558
160Type II lissencephaly (HP:0007260)1.53290388
161Bowel diverticulosis (HP:0005222)1.53126218
162Hip contracture (HP:0003273)1.49989052
163Prominent supraorbital ridges (HP:0000336)1.49891015
164Absent speech (HP:0001344)1.49095409
165Abnormal respiratory epithelium morphology (HP:0012253)1.49002853
166Abnormal respiratory motile cilium morphology (HP:0005938)1.49002853
167Hypomagnesemia (HP:0002917)1.45685845
168Arterial tortuosity (HP:0005116)1.44822537

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.09074625
2PNCK3.97960132
3MAP3K123.78310224
4MAP3K43.75794974
5NTRK13.32732115
6GRK73.21416895
7MAP2K73.12401919
8NTRK33.03847099
9GRK52.89504617
10MAP2K42.58316435
11MAPKAPK52.54513393
12MAP3K92.51976044
13CASK2.29763621
14MINK12.18980605
15MARK11.96866010
16NTRK21.95710974
17STK38L1.66422763
18FGFR21.64927836
19PRKD31.59014791
20PLK21.54075375
21CSNK1G31.53226799
22CSNK1G21.51677717
23TNIK1.50668893
24PINK11.49195598
25LIMK11.48166538
26NME11.47658698
27STK391.43722923
28MYLK1.37315206
29ARAF1.31965844
30LATS11.30073064
31WNK11.29881607
32MET1.28231013
33CAMKK21.28229528
34ACVR1B1.26374897
35UHMK11.25758812
36WNK41.25103855
37MAPK131.23237251
38ADRBK11.23114279
39CAMK2A1.21693171
40GRK11.19248905
41TRPM71.16459172
42EPHA21.12613760
43PHKG11.11797269
44PHKG21.11797269
45CDK51.09994971
46CAMK2D1.09743401
47DAPK21.09578835
48DMPK1.07233741
49CAMK2B1.06400700
50CAMK1G1.03640560
51FGR1.03370623
52PIK3CA1.01159821
53MST1R1.00554483
54AKT31.00024123
55STK240.99681318
56CSNK1G10.98335997
57SIK20.97735352
58RET0.97467711
59STK160.96736046
60CDK190.96649941
61PRKCG0.95499489
62RIPK40.95283054
63EPHA40.93957044
64MATK0.93836945
65PTK2B0.93768158
66OXSR10.92813173
67ADRBK20.87871696
68PRKCE0.86749470
69CAMK2G0.82847235
70LATS20.82553044
71STK30.79290863
72TSSK60.78313243
73MAP2K10.77901848
74ERBB30.77512519
75ROCK10.77496949
76FES0.76714647
77MAP3K20.75818473
78GRK60.75028793
79KSR20.73840208
80PRKD20.73701774
81PAK20.72958214
82CDK140.72410674
83CAMK1D0.71828684
84CDK180.71612244
85CDK150.70277728
86MUSK0.70150565
87EPHB20.69508437
88PDGFRA0.68935217
89PRKAA10.68302121
90PAK60.68048476
91PAK30.66862737
92MKNK20.66833507
93MAP3K60.66669633
94INSRR0.65102476
95DYRK1A0.62993226
96BMPR1B0.62741013
97CDK11A0.61605856
98DAPK10.61248275
99SGK4940.59292992
100SGK2230.59292992
101SGK30.56463181
102ROCK20.55802167
103NUAK10.55229887
104CAMK10.54254960
105BCR0.53861566
106LMTK20.53493150
107MAPK150.53315919
108STK110.52960251
109PRKACA0.50309343
110MST40.50157953
111DDR20.49940911
112CAMKK10.49466790
113PRKAA20.48347661
114RPS6KA20.46395989
115FER0.45858549
116CSNK1E0.45632514
117PRKCZ0.45135925
118STK380.44330961
119WNK30.43086698
120BMPR20.42726220
121ERBB40.42356397
122ERBB20.40427187
123ILK0.39684770
124RIPK10.39666904
125SGK10.38573665
126PRKG10.37199007
127SIK30.36395551
128PRKCB0.36378601
129CDC42BPA0.34530772
130MAP3K130.34455017
131PRKCH0.33832643
132TIE10.33591875
133PTK20.32443346
134SGK20.32256649
135RPS6KA30.31775729
136KSR10.31411583
137PRKACB0.31301221
138PDK30.30857163

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.66570749
2Oxidative phosphorylation_Homo sapiens_hsa001903.47127527
3Synaptic vesicle cycle_Homo sapiens_hsa047213.30939844
4Parkinsons disease_Homo sapiens_hsa050123.17334421
5Amphetamine addiction_Homo sapiens_hsa050312.91922590
6Cocaine addiction_Homo sapiens_hsa050302.83371625
7Maturity onset diabetes of the young_Homo sapiens_hsa049502.60946512
8Collecting duct acid secretion_Homo sapiens_hsa049662.52530537
9Alzheimers disease_Homo sapiens_hsa050102.40859003
10* Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.39962274
11GABAergic synapse_Homo sapiens_hsa047272.30248951
12* Dopaminergic synapse_Homo sapiens_hsa047282.29213487
13Taste transduction_Homo sapiens_hsa047422.14368078
14* Serotonergic synapse_Homo sapiens_hsa047262.14199525
15Cardiac muscle contraction_Homo sapiens_hsa042602.09495351
16Morphine addiction_Homo sapiens_hsa050321.99047756
17Tyrosine metabolism_Homo sapiens_hsa003501.94186552
18Olfactory transduction_Homo sapiens_hsa047401.92702189
19Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.91294292
20* Glutamatergic synapse_Homo sapiens_hsa047241.90809946
21* Circadian entrainment_Homo sapiens_hsa047131.90583409
22* Cholinergic synapse_Homo sapiens_hsa047251.86888949
23Phenylalanine metabolism_Homo sapiens_hsa003601.86275012
24Huntingtons disease_Homo sapiens_hsa050161.81961099
25* Long-term potentiation_Homo sapiens_hsa047201.79163503
26* Long-term depression_Homo sapiens_hsa047301.64101176
27Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.57099184
28* Salivary secretion_Homo sapiens_hsa049701.56211715
29Vibrio cholerae infection_Homo sapiens_hsa051101.53012139
30Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.51874758
31Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.51850049
32* Renin secretion_Homo sapiens_hsa049241.48980870
33* Insulin secretion_Homo sapiens_hsa049111.48445608
34* Calcium signaling pathway_Homo sapiens_hsa040201.38736739
35* Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.28793365
36* Gastric acid secretion_Homo sapiens_hsa049711.27406990
37* Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.24869285
38* Oxytocin signaling pathway_Homo sapiens_hsa049211.22511281
39Phototransduction_Homo sapiens_hsa047441.21478453
40* GnRH signaling pathway_Homo sapiens_hsa049121.17741692
41Tight junction_Homo sapiens_hsa045301.17246336
42Protein export_Homo sapiens_hsa030601.17048981
43* Aldosterone synthesis and secretion_Homo sapiens_hsa049251.14267915
44Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.11967818
45ECM-receptor interaction_Homo sapiens_hsa045121.11468811
46Hippo signaling pathway_Homo sapiens_hsa043901.10981045
47* Gap junction_Homo sapiens_hsa045401.08959627
48* Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.06746537
49Hedgehog signaling pathway_Homo sapiens_hsa043401.06602559
50Vitamin B6 metabolism_Homo sapiens_hsa007501.00608174
51Nitrogen metabolism_Homo sapiens_hsa009101.00022711
52* Estrogen signaling pathway_Homo sapiens_hsa049150.91593441
53cAMP signaling pathway_Homo sapiens_hsa040240.90670397
54* Pancreatic secretion_Homo sapiens_hsa049720.88857914
55* Vascular smooth muscle contraction_Homo sapiens_hsa042700.88845554
56Histidine metabolism_Homo sapiens_hsa003400.85944462
57Dilated cardiomyopathy_Homo sapiens_hsa054140.85756473
58Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.85556173
59Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.82388009
60Mineral absorption_Homo sapiens_hsa049780.81689804
61Adherens junction_Homo sapiens_hsa045200.80614489
62Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.79220659
63Protein digestion and absorption_Homo sapiens_hsa049740.78916764
64Dorso-ventral axis formation_Homo sapiens_hsa043200.78886535
65Focal adhesion_Homo sapiens_hsa045100.78555068
66Alcoholism_Homo sapiens_hsa050340.78352563
67Melanoma_Homo sapiens_hsa052180.77632291
68* cGMP-PKG signaling pathway_Homo sapiens_hsa040220.76603969
69Type II diabetes mellitus_Homo sapiens_hsa049300.74484191
70Rheumatoid arthritis_Homo sapiens_hsa053230.72806763
71Propanoate metabolism_Homo sapiens_hsa006400.72425218
72Axon guidance_Homo sapiens_hsa043600.71320022
73Basal cell carcinoma_Homo sapiens_hsa052170.71317729
74Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.70114758
75Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.69681425
76Sphingolipid metabolism_Homo sapiens_hsa006000.69417483
77AMPK signaling pathway_Homo sapiens_hsa041520.68763262
78Lysine degradation_Homo sapiens_hsa003100.68092567
79Regulation of autophagy_Homo sapiens_hsa041400.67878160
80TGF-beta signaling pathway_Homo sapiens_hsa043500.67332239
81Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.65312955
82Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.64645312
83Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.64602101
84Tryptophan metabolism_Homo sapiens_hsa003800.63800498
85Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.62307583
86* Melanogenesis_Homo sapiens_hsa049160.61598871
87* Phosphatidylinositol signaling system_Homo sapiens_hsa040700.59482614
88Selenocompound metabolism_Homo sapiens_hsa004500.58062768
89Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.55440463
90Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.54636464
91Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.54327168
92* Thyroid hormone synthesis_Homo sapiens_hsa049180.52686362
93Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.52535666
94Ovarian steroidogenesis_Homo sapiens_hsa049130.51946318
95Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.50499933
96Oocyte meiosis_Homo sapiens_hsa041140.49500021
97beta-Alanine metabolism_Homo sapiens_hsa004100.48744371
98Regulation of actin cytoskeleton_Homo sapiens_hsa048100.48008308
99ErbB signaling pathway_Homo sapiens_hsa040120.47553766
100MAPK signaling pathway_Homo sapiens_hsa040100.47313688
101Longevity regulating pathway - mammal_Homo sapiens_hsa042110.46968477
102Proteoglycans in cancer_Homo sapiens_hsa052050.46579418
103Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.45256303
104PI3K-Akt signaling pathway_Homo sapiens_hsa041510.44764568
105* Thyroid hormone signaling pathway_Homo sapiens_hsa049190.44484595
106mTOR signaling pathway_Homo sapiens_hsa041500.43546924
107Circadian rhythm_Homo sapiens_hsa047100.43152223
108Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.43035557
109Pyruvate metabolism_Homo sapiens_hsa006200.42520598
110Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.39659783
111Glioma_Homo sapiens_hsa052140.39354511
112Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.39074946
113Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.38455428
114* Glucagon signaling pathway_Homo sapiens_hsa049220.37394592
115Bile secretion_Homo sapiens_hsa049760.37207184
116Phagosome_Homo sapiens_hsa041450.37096911
117* Phospholipase D signaling pathway_Homo sapiens_hsa040720.35834535
118Choline metabolism in cancer_Homo sapiens_hsa052310.35804919
119Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.34434741
120Ras signaling pathway_Homo sapiens_hsa040140.29382860
121Glycerophospholipid metabolism_Homo sapiens_hsa005640.29046713
122Prion diseases_Homo sapiens_hsa050200.26903630
123Butanoate metabolism_Homo sapiens_hsa006500.25677669
124Sulfur metabolism_Homo sapiens_hsa009200.23593095
125Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.21017225
126Fatty acid elongation_Homo sapiens_hsa000620.21008348
127Insulin signaling pathway_Homo sapiens_hsa049100.20585130
128VEGF signaling pathway_Homo sapiens_hsa043700.20246361
129Neurotrophin signaling pathway_Homo sapiens_hsa047220.18799692
130* Inositol phosphate metabolism_Homo sapiens_hsa005620.18376899
131Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.18137606
132* Sphingolipid signaling pathway_Homo sapiens_hsa040710.16503696
133Proteasome_Homo sapiens_hsa030500.15802349
134Ether lipid metabolism_Homo sapiens_hsa005650.14557142
135* Wnt signaling pathway_Homo sapiens_hsa043100.14476129
136* Rap1 signaling pathway_Homo sapiens_hsa040150.11283182
137Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.09665818

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