PLCD1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the phospholipase C family. Phospholipase C isozymes play critical roles in intracellular signal transduction by catalyzing the hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) into the second messengers diacylglycerol (DAG) and inositol triphosphate (IP3). The encoded protein functions as a tumor suppressor in several types of cancer, and mutations in this gene are a cause of hereditary leukonychia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1phospholipid efflux (GO:0033700)6.49388692
2plasma lipoprotein particle assembly (GO:0034377)5.60346908
3notochord development (GO:0030903)5.57214196
4regulation of cholesterol esterification (GO:0010872)5.56201677
5cholesterol biosynthetic process (GO:0006695)5.38310881
6protein-lipid complex assembly (GO:0065005)5.25162597
7COPI coating of Golgi vesicle (GO:0048205)4.92223644
8Golgi transport vesicle coating (GO:0048200)4.92223644
9fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.87058969
10sterol biosynthetic process (GO:0016126)4.85854881
11high-density lipoprotein particle remodeling (GO:0034375)4.74384059
12negative regulation of lipase activity (GO:0060192)4.71274032
13paraxial mesoderm development (GO:0048339)4.70515124
14isoprenoid biosynthetic process (GO:0008299)4.66182249
15regulation of heterotypic cell-cell adhesion (GO:0034114)4.57317406
16reverse cholesterol transport (GO:0043691)4.51643126
17positive regulation of heterotypic cell-cell adhesion (GO:0034116)4.43873104
18bone trabecula formation (GO:0060346)4.28592693
19regulation of posttranscriptional gene silencing (GO:0060147)4.26466755
20regulation of gene silencing by miRNA (GO:0060964)4.26466755
21regulation of gene silencing by RNA (GO:0060966)4.26466755
22lipoprotein transport (GO:0042953)4.12953830
23tricarboxylic acid metabolic process (GO:0072350)4.03579803
24embryonic camera-type eye development (GO:0031076)3.95069470
25intestinal epithelial cell development (GO:0060576)3.93994643
26cholesterol efflux (GO:0033344)3.93982321
27regulation of cytokine secretion involved in immune response (GO:0002739)3.88615417
28alpha-linolenic acid metabolic process (GO:0036109)3.88442989
29regulation of response to osmotic stress (GO:0047484)3.87401160
30cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.83161475
314-hydroxyproline metabolic process (GO:0019471)3.82439813
32homocysteine metabolic process (GO:0050667)3.80772169
33galactose catabolic process (GO:0019388)3.74085404
34glycolytic process (GO:0006096)3.73326022
35desmosome organization (GO:0002934)3.71294826
36formation of translation preinitiation complex (GO:0001731)3.71211324
37valine metabolic process (GO:0006573)3.69109829
38epithelial cell-cell adhesion (GO:0090136)3.68757098
39negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)3.66335301
40peptidyl-proline hydroxylation (GO:0019511)3.64217842
41response to vitamin A (GO:0033189)3.59683150
42glutamine family amino acid biosynthetic process (GO:0009084)3.57822489
43collagen fibril organization (GO:0030199)3.57219711
44negative regulation of epidermis development (GO:0045683)3.56501876
45retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.54160230
46creatine metabolic process (GO:0006600)3.50739425
47establishment of skin barrier (GO:0061436)3.48238154
48arginine catabolic process (GO:0006527)3.47204789
49regulation of water loss via skin (GO:0033561)3.44456842
50chondrocyte proliferation (GO:0035988)3.44427604
51plasma lipoprotein particle clearance (GO:0034381)3.44058704
52lung-associated mesenchyme development (GO:0060484)3.43477881
53regulation of cardioblast differentiation (GO:0051890)3.42090587
54triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.41627201
55keratan sulfate catabolic process (GO:0042340)3.40167241
56heterochromatin organization (GO:0070828)3.36628661
57fatty acid elongation (GO:0030497)3.36473534
58negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.36230598
59interferon-gamma secretion (GO:0072643)3.35698874
60regulation of G0 to G1 transition (GO:0070316)3.34816193
61cellular ketone body metabolic process (GO:0046950)3.34050943
62positive regulation of Rho protein signal transduction (GO:0035025)3.32634232
63negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)3.32581763
64protein hydroxylation (GO:0018126)3.28341421
65protein localization to kinetochore (GO:0034501)3.27885660
66cellular response to oxygen radical (GO:0071450)3.25688710
67removal of superoxide radicals (GO:0019430)3.25688710
68cellular response to superoxide (GO:0071451)3.25688710
69trophectodermal cell differentiation (GO:0001829)3.19308564
70polyketide metabolic process (GO:0030638)3.19272009
71doxorubicin metabolic process (GO:0044598)3.19272009
72daunorubicin metabolic process (GO:0044597)3.19272009
73pyrimidine dimer repair (GO:0006290)3.17949894
74bile acid biosynthetic process (GO:0006699)3.17729835
75regulation of mammary gland epithelial cell proliferation (GO:0033599)3.16272744
76negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)3.14648982
77regulation of hippo signaling (GO:0035330)3.13798735
78hemidesmosome assembly (GO:0031581)3.09055346
79tricarboxylic acid cycle (GO:0006099)3.08567804
80C21-steroid hormone metabolic process (GO:0008207)3.07755195
81somite rostral/caudal axis specification (GO:0032525)3.07400187
82erythrocyte maturation (GO:0043249)3.06262848
83glyoxylate metabolic process (GO:0046487)3.05605224
84cartilage condensation (GO:0001502)3.04847091
85cell aggregation (GO:0098743)3.04847091
86histone H4 deacetylation (GO:0070933)3.02835693
87proline biosynthetic process (GO:0006561)3.02549603
88gas transport (GO:0015669)3.02444217
89positive regulation of mitochondrial fission (GO:0090141)3.01613927
90terpenoid biosynthetic process (GO:0016114)3.01030727
91vesicle coating (GO:0006901)2.99243890
92wound healing, spreading of epidermal cells (GO:0035313)2.99154823
93regulation of translation in response to stress (GO:0043555)2.96706846
94aldehyde catabolic process (GO:0046185)2.95188214
95glucose 6-phosphate metabolic process (GO:0051156)2.94831428
96regulation of tight junction assembly (GO:2000810)2.92972894
97regulation of nuclear cell cycle DNA replication (GO:0033262)2.92671460
98phospholipid homeostasis (GO:0055091)2.92330111
99very-low-density lipoprotein particle assembly (GO:0034379)2.91048871
100regulation of SMAD protein import into nucleus (GO:0060390)2.89243066
101ketone body metabolic process (GO:1902224)2.88882658
102muscle organ morphogenesis (GO:0048644)2.88386451
103regulation of hair follicle development (GO:0051797)2.87601724
104heme metabolic process (GO:0042168)2.83881629
105cullin deneddylation (GO:0010388)2.83855807
106cellular response to leptin stimulus (GO:0044320)2.83848490
107anterior/posterior axis specification, embryo (GO:0008595)2.83036234
108progesterone metabolic process (GO:0042448)2.82078913
109protein heterotrimerization (GO:0070208)2.81215293
110plasma lipoprotein particle organization (GO:0071827)2.81213611
111ribosome biogenesis (GO:0042254)2.80259857
112protein-lipid complex subunit organization (GO:0071825)2.78939338
113hippo signaling (GO:0035329)2.78687605
114cholesterol metabolic process (GO:0008203)2.78626170
115positive regulation of SMAD protein import into nucleus (GO:0060391)2.78605494
116cardiac right ventricle morphogenesis (GO:0003215)2.78599739
117endodermal cell differentiation (GO:0035987)2.78243640
118one-carbon compound transport (GO:0019755)2.74664789
119blood vessel maturation (GO:0001955)2.72695518
120plasma membrane repair (GO:0001778)2.72556369
121basement membrane organization (GO:0071711)2.72221935
122response to superoxide (GO:0000303)2.70203377
123negative regulation of cell cycle G2/M phase transition (GO:1902750)2.68062216
124protein-lipid complex remodeling (GO:0034368)2.67421237
125macromolecular complex remodeling (GO:0034367)2.67421237
126plasma lipoprotein particle remodeling (GO:0034369)2.67421237
127positive regulation of substrate adhesion-dependent cell spreading (GO:1900026)2.67074402
128histone H3-K9 demethylation (GO:0033169)2.67006418
129response to leptin (GO:0044321)2.66722253
130skin morphogenesis (GO:0043589)2.65743442
131ventricular cardiac muscle cell development (GO:0055015)2.65021998
132negative regulation of potassium ion transmembrane transport (GO:1901380)2.64022826
133short-chain fatty acid metabolic process (GO:0046459)2.63493556
134regulation of transforming growth factor beta2 production (GO:0032909)2.63038743
135nucleotide-sugar biosynthetic process (GO:0009226)2.62095002
136ribosomal small subunit assembly (GO:0000028)2.61956081
137positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.61784314
138mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.61784314
139pyrimidine nucleobase catabolic process (GO:0006208)2.60956661
140platelet dense granule organization (GO:0060155)2.60538958
141lens fiber cell development (GO:0070307)2.59704754
142negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.58950056
143diterpenoid biosynthetic process (GO:0016102)2.58715660
144polyamine biosynthetic process (GO:0006596)2.58130561
145response to oxygen radical (GO:0000305)2.58025889
146branching involved in mammary gland duct morphogenesis (GO:0060444)2.57252856
147resolution of meiotic recombination intermediates (GO:0000712)2.57157645
148negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.56871008
149vitamin A metabolic process (GO:0006776)2.56413342
150negative regulation of telomerase activity (GO:0051974)2.56260993
151protoporphyrinogen IX biosynthetic process (GO:0006782)2.55135267
152negative regulation of epidermal cell differentiation (GO:0045605)2.54574279
153regulation of striated muscle cell apoptotic process (GO:0010662)2.54172210
154rRNA modification (GO:0000154)2.53661635
155DNA replication-dependent nucleosome assembly (GO:0006335)2.53608561
156DNA replication-dependent nucleosome organization (GO:0034723)2.53608561
157DNA replication checkpoint (GO:0000076)2.53547073
158positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.53292064
159porphyrin-containing compound metabolic process (GO:0006778)2.53108176
160negative regulation of keratinocyte proliferation (GO:0010839)2.52748250
161planar cell polarity pathway involved in neural tube closure (GO:0090179)2.52077200
162histone arginine methylation (GO:0034969)2.52031864
163cytidine metabolic process (GO:0046087)2.51701085
164cytidine catabolic process (GO:0006216)2.51701085
165cytidine deamination (GO:0009972)2.51701085
166sterol metabolic process (GO:0016125)2.51227562
167oxygen transport (GO:0015671)2.49475662
168sensory perception of smell (GO:0007608)2.49308615
169regulation of tumor necrosis factor-mediated signaling pathway (GO:0010803)2.49192586
170proline metabolic process (GO:0006560)2.48532586
171cholesterol transport (GO:0030301)2.48218200
172sterol transport (GO:0015918)2.48218200
173NADPH regeneration (GO:0006740)2.48105359
174positive regulation of epidermis development (GO:0045684)2.47796354
175regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.47735151
176L-serine metabolic process (GO:0006563)2.46829351
177histone H4-K8 acetylation (GO:0043982)2.46809397
178histone H4-K5 acetylation (GO:0043981)2.46809397
179ectoderm development (GO:0007398)2.45618567
180heme biosynthetic process (GO:0006783)2.45587496
181regulation of cholesterol metabolic process (GO:0090181)2.45253911
182mammary gland development (GO:0030879)2.43420114
183eyelid development in camera-type eye (GO:0061029)2.42578881
184ribosome assembly (GO:0042255)2.42571648
185molting cycle (GO:0042303)2.42218940
186hair cycle (GO:0042633)2.42218940
187regulation of odontogenesis of dentin-containing tooth (GO:0042487)2.40479674
188folic acid transport (GO:0015884)2.39456918
189cellular response to interferon-alpha (GO:0035457)2.39330804
190chondrocyte development (GO:0002063)2.38983007
191cell fate commitment involved in formation of primary germ layer (GO:0060795)2.38067444
192endothelial cell morphogenesis (GO:0001886)2.37070013
193regulation of telomere maintenance via telomerase (GO:0032210)2.35787307
194negative regulation of catenin import into nucleus (GO:0035414)2.35681364
195regulation of epidermis development (GO:0045682)2.35370162
196maintenance of protein location in nucleus (GO:0051457)2.33481099
197collagen metabolic process (GO:0032963)2.32504370
198regulation of cardiac muscle cell apoptotic process (GO:0010665)2.31920503

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human6.05755518
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.36187739
3KLF5_18264089_ChIP-ChIP_MESCs_Mouse4.00589270
4KLF4_18264089_ChIP-ChIP_MESCs_Mouse4.00589270
5KLF2_18264089_ChIP-ChIP_MESCs_Mouse4.00589270
6E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.72956249
7RBPJ_22232070_ChIP-Seq_NCS_Mouse3.46512092
8NANOG_18700969_ChIP-ChIP_MESCs_Mouse3.10176170
9POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.97518873
10TRIM28_21343339_ChIP-Seq_HEK293_Human2.76101416
11* NCOR1_26117541_ChIP-Seq_K562_Human2.53879659
12PRDM5_23873026_ChIP-Seq_MEFs_Mouse2.49685579
13NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.42504169
14CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.41948447
15STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.41890855
16CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.37522150
17HIF1A_21447827_ChIP-Seq_MCF-7_Human2.35078116
18MYC_18555785_ChIP-Seq_MESCs_Mouse2.31421458
19CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.29430773
20TCF3_18692474_ChIP-Seq_MEFs_Mouse2.29051665
21E2F7_22180533_ChIP-Seq_HELA_Human2.27032643
22ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.26144606
23RARG_19884340_ChIP-ChIP_MEFs_Mouse2.24743091
24SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.23964025
25SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.20776053
26HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.15679874
27CCND1_20090754_ChIP-ChIP_RETINA_Mouse2.10411602
28* KLF4_18358816_ChIP-ChIP_MESCs_Mouse2.08812457
29ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.05979862
30SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.04315204
31STAT3_1855785_ChIP-Seq_MESCs_Mouse2.00402326
32MYC_19079543_ChIP-ChIP_MESCs_Mouse1.99866417
33NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.98287324
34GABP_17652178_ChIP-ChIP_JURKAT_Human1.92233505
35ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.88205146
36TCF3_18692474_ChIP-Seq_MESCs_Mouse1.83759899
37NANOG_18555785_ChIP-Seq_MESCs_Mouse1.81067562
38TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.80824750
39NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.78287851
40GABP_19822575_ChIP-Seq_HepG2_Human1.76323185
41THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.74804582
42TP63_19390658_ChIP-ChIP_HaCaT_Human1.74488566
43WT1_19549856_ChIP-ChIP_CCG9911_Human1.72265401
44EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.70086950
45THAP11_20581084_ChIP-Seq_MESCs_Mouse1.66335419
46GATA1_19941826_ChIP-Seq_K562_Human1.66217103
47SRF_21415370_ChIP-Seq_HL-1_Mouse1.66213191
48KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.61840110
49NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.60123398
50ESR2_21235772_ChIP-Seq_MCF-7_Human1.59898049
51ZFP281_18757296_ChIP-ChIP_E14_Mouse1.57855614
52NANOG_18692474_ChIP-Seq_MEFs_Mouse1.54954237
53EGR1_19032775_ChIP-ChIP_M12_Human1.51764071
54NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.51657557
55MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.51519997
56OCT4_18692474_ChIP-Seq_MEFs_Mouse1.49321812
57MYC_19030024_ChIP-ChIP_MESCs_Mouse1.47014183
58ATF3_27146783_Chip-Seq_COLON_Human1.46232774
59ESR1_21235772_ChIP-Seq_MCF-7_Human1.44374541
60RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.43891100
61POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.43435027
62SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.42753792
63MYC_18358816_ChIP-ChIP_MESCs_Mouse1.42346418
64PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.41222803
65AR_21909140_ChIP-Seq_LNCAP_Human1.39201611
66CREB1_15753290_ChIP-ChIP_HEK293T_Human1.38451543
67TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.38072855
68SOX2_18692474_ChIP-Seq_MEFs_Mouse1.37692822
69EZH2_22144423_ChIP-Seq_EOC_Human1.36434120
70TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.34007355
71FOXM1_23109430_ChIP-Seq_U2OS_Human1.33479947
72RACK7_27058665_Chip-Seq_MCF-7_Human1.33377430
73DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.32057916
74PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.31512549
75ELK3_25401928_ChIP-Seq_HUVEC_Human1.31492760
76GATA2_19941826_ChIP-Seq_K562_Human1.31089050
77MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.30758463
78CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.30550211
79CLOCK_20551151_ChIP-Seq_293T_Human1.29815766
80SA1_27219007_Chip-Seq_ERYTHROID_Human1.29684795
81SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.28865147
82BP1_19119308_ChIP-ChIP_Hs578T_Human1.28671994
83NANOG_18692474_ChIP-Seq_MESCs_Mouse1.28180715
84TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.27168330
85TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.26340428
86TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.24964586
87KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.23622220
88TP53_22127205_ChIP-Seq_IMR90_Human1.20835618
89ELF1_17652178_ChIP-ChIP_JURKAT_Human1.20439823
90NANOG_21062744_ChIP-ChIP_HESCs_Human1.19782570
91KLF4_18555785_ChIP-Seq_MESCs_Mouse1.19573682
92MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.19398998
93SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.18591609
94* EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.18504711
95YY1_22570637_ChIP-Seq_MALME-3M_Human1.17162297
96EST1_17652178_ChIP-ChIP_JURKAT_Human1.16624823
97TP53_20018659_ChIP-ChIP_R1E_Mouse1.16260483
98ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.15648944
99STAT6_21828071_ChIP-Seq_BEAS2B_Human1.15472262
100POU5F1_16518401_ChIP-PET_MESCs_Mouse1.14215525
101NELFA_20434984_ChIP-Seq_ESCs_Mouse1.13101134
102SOX2_18555785_ChIP-Seq_MESCs_Mouse1.12623315
103POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.12156175
104UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.11788630
105CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.11537201
106DCP1A_22483619_ChIP-Seq_HELA_Human1.10590662
107ETS1_20019798_ChIP-Seq_JURKAT_Human1.10516210
108HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.09804571
109ELK1_22589737_ChIP-Seq_MCF10A_Human1.08825952
110CTCF_27219007_Chip-Seq_Bcells_Human1.08429065
111SPI1_23127762_ChIP-Seq_K562_Human1.08314449
112SRY_22984422_ChIP-ChIP_TESTIS_Rat1.08287728
113CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.08002742
114HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.07407379
115HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.06874868
116SOX2_18692474_ChIP-Seq_MESCs_Mouse1.06657977
117EGR1_19374776_ChIP-ChIP_THP-1_Human1.05905190
118PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.05507258
119NANOG_16153702_ChIP-ChIP_HESCs_Human1.05168221
120E2F1_18555785_ChIP-Seq_MESCs_Mouse1.04921114
121ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.04388092
122* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.04113909
123EOMES_21245162_ChIP-Seq_HESCs_Human1.02860016
124FOXP1_21924763_ChIP-Seq_HESCs_Human1.02707548
125MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.01292469
126TTF2_22483619_ChIP-Seq_HELA_Human1.01196248
127NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.00632781
128PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.00521150
129KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.99655992
130XRN2_22483619_ChIP-Seq_HELA_Human0.99446928
131CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.99040547
132* ELF1_20517297_ChIP-Seq_JURKAT_Human0.98850774
133SALL1_21062744_ChIP-ChIP_HESCs_Human0.98327819
134HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.98289502
135TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.97906970
136MYCN_18555785_ChIP-Seq_MESCs_Mouse0.97760957
137TBX5_21415370_ChIP-Seq_HL-1_Mouse0.97737598
138SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.97585285
139ZNF263_19887448_ChIP-Seq_K562_Human0.96503402
140HOXB4_20404135_ChIP-ChIP_EML_Mouse0.96273419
141ZFP281_27345836_Chip-Seq_ESCs_Mouse0.95751165
142P63_26484246_Chip-Seq_KERATINOCYTES_Human0.95547349
143NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.95008652
144YY1_21170310_ChIP-Seq_MESCs_Mouse0.93425879
145* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.92886235
146VDR_23849224_ChIP-Seq_CD4+_Human0.91887422
147POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.91579615
148PHF8_20622854_ChIP-Seq_HELA_Human0.90063496
149E2F4_17652178_ChIP-ChIP_JURKAT_Human0.89695087
150CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.89005578
151FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.88885803
152CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.88336314
153P300_27058665_Chip-Seq_ZR-75-30cells_Human0.88153292
154SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.87810687
155TP53_16413492_ChIP-PET_HCT116_Human0.87742505
156KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.87704023
157JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.87095870
158RARB_24833708_ChIP-Seq_LIVER_Mouse0.87013909
159NANOG_16518401_ChIP-PET_MESCs_Mouse0.86908253
160ZFX_18555785_ChIP-Seq_MESCs_Mouse0.85743649
161LXR_22292898_ChIP-Seq_THP-1_Human0.85510755

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog4.17098832
2MP0009840_abnormal_foam_cell4.05838647
3MP0005171_absent_coat_pigmentation3.61091149
4MP0003136_yellow_coat_color3.47013106
5MP0008438_abnormal_cutaneous_collagen3.26554244
6MP0003191_abnormal_cellular_cholesterol3.26025627
7MP0008995_early_reproductive_senescence3.25605188
8MP0005275_abnormal_skin_tensile3.10344874
9MP0005670_abnormal_white_adipose3.00678608
10MP0010030_abnormal_orbit_morphology2.99577473
11MP0010352_gastrointestinal_tract_polyps2.38326141
12MP0004147_increased_porphyrin_level2.31917046
13MP0001986_abnormal_taste_sensitivity2.20852896
14MP0003880_abnormal_central_pattern2.16392738
15MP0005503_abnormal_tendon_morphology2.14255919
16MP0001299_abnormal_eye_distance/2.09148453
17MP0003566_abnormal_cell_adhesion2.08825501
18MP0008260_abnormal_autophagy2.08348554
19MP0004272_abnormal_basement_membrane2.05615207
20MP0003941_abnormal_skin_development2.01068413
21MP0002653_abnormal_ependyma_morphology1.97000394
22MP0002254_reproductive_system_inflammat1.96508360
23MP0004084_abnormal_cardiac_muscle1.94367373
24MP0000372_irregular_coat_pigmentation1.91495676
25MP0000762_abnormal_tongue_morphology1.91016053
26MP0005623_abnormal_meninges_morphology1.90723655
27MP0002938_white_spotting1.89230096
28MP0000750_abnormal_muscle_regeneration1.88494827
29MP0002796_impaired_skin_barrier1.87300601
30MP0005508_abnormal_skeleton_morphology1.87099194
31MP0002095_abnormal_skin_pigmentation1.86213596
32MP0005257_abnormal_intraocular_pressure1.82532849
33MP0003283_abnormal_digestive_organ1.80897686
34MP0004957_abnormal_blastocyst_morpholog1.76644169
35MP0003646_muscle_fatigue1.75863712
36MP0005248_abnormal_Harderian_gland1.75002654
37MP0000015_abnormal_ear_pigmentation1.72789340
38MP0003329_amyloid_beta_deposits1.70941890
39MP0000566_synostosis1.70537460
40MP0006054_spinal_hemorrhage1.70004223
41MP0003279_aneurysm1.64770577
42MP0003186_abnormal_redox_activity1.64712441
43MP0000751_myopathy1.63141237
44MP0004019_abnormal_vitamin_homeostasis1.58619317
45MP0009379_abnormal_foot_pigmentation1.58417774
46MP0002638_abnormal_pupillary_reflex1.57603852
47MP0003315_abnormal_perineum_morphology1.53771861
48MP0001984_abnormal_olfaction1.53580791
49MP0005023_abnormal_wound_healing1.51952670
50MP0005408_hypopigmentation1.51309504
51MP0009250_abnormal_appendicular_skeleto1.50762258
52MP0003122_maternal_imprinting1.49896140
53MP0000604_amyloidosis1.49012560
54MP0003011_delayed_dark_adaptation1.48428457
55MP0004381_abnormal_hair_follicle1.46140246
56MP0001542_abnormal_bone_strength1.45641728
57MP0002234_abnormal_pharynx_morphology1.42403752
58MP0003755_abnormal_palate_morphology1.42070760
59MP0002282_abnormal_trachea_morphology1.40466994
60MP0004185_abnormal_adipocyte_glucose1.39763319
61MP0000428_abnormal_craniofacial_morphol1.37408012
62MP0000579_abnormal_nail_morphology1.36371886
63MP0000778_abnormal_nervous_system1.35872092
64MP0003123_paternal_imprinting1.35547658
65MP0009384_cardiac_valve_regurgitation1.34172918
66MP0010329_abnormal_lipoprotein_level1.33347568
67MP0000537_abnormal_urethra_morphology1.32185278
68MP0002332_abnormal_exercise_endurance1.32129736
69MP0000049_abnormal_middle_ear1.31591103
70MP0003693_abnormal_embryo_hatching1.29923782
71MP0004133_heterotaxia1.28896305
72MP0000163_abnormal_cartilage_morphology1.28042579
73MP0004858_abnormal_nervous_system1.27691353
74MP0005451_abnormal_body_composition1.27486970
75MP0003119_abnormal_digestive_system1.26075357
76MP0005501_abnormal_skin_physiology1.25829642
77MP0000749_muscle_degeneration1.25371143
78MP0004883_abnormal_blood_vessel1.24744808
79MP0005367_renal/urinary_system_phenotyp1.24523916
80MP0000516_abnormal_urinary_system1.24523916
81MP0005365_abnormal_bile_salt1.22850269
82MP0001529_abnormal_vocalization1.22276408
83MP0000678_abnormal_parathyroid_gland1.21837442
84MP0004197_abnormal_fetal_growth/weight/1.19821171
85MP0005394_taste/olfaction_phenotype1.18806281
86MP0005499_abnormal_olfactory_system1.18806281
87MP0001672_abnormal_embryogenesis/_devel1.18258416
88MP0005380_embryogenesis_phenotype1.18258416
89MP0003567_abnormal_fetal_cardiomyocyte1.17552250
90MP0002932_abnormal_joint_morphology1.17284277
91MP0002233_abnormal_nose_morphology1.16944668
92MP0005083_abnormal_biliary_tract1.16539111
93MP0004264_abnormal_extraembryonic_tissu1.16292432
94MP0009053_abnormal_anal_canal1.15131457
95MP0002088_abnormal_embryonic_growth/wei1.14829275
96MP0001958_emphysema1.14705234
97MP0002060_abnormal_skin_morphology1.14279534
98MP0003984_embryonic_growth_retardation1.13661338
99MP0003937_abnormal_limbs/digits/tail_de1.13652089
100MP0000467_abnormal_esophagus_morphology1.13263162
101MP0006035_abnormal_mitochondrial_morpho1.11676375
102MP0010234_abnormal_vibrissa_follicle1.11480532
103MP0002111_abnormal_tail_morphology1.10914532
104MP0003890_abnormal_embryonic-extraembry1.10743274
105MP0000432_abnormal_head_morphology1.10169043
106MP0006276_abnormal_autonomic_nervous1.09644088
107MP0005330_cardiomyopathy1.09565214
108MP0003935_abnormal_craniofacial_develop1.08603181
109MP0003111_abnormal_nucleus_morphology1.08548500
110MP0003786_premature_aging1.08271774
111MP0002098_abnormal_vibrissa_morphology1.07837011
112MP0004142_abnormal_muscle_tone1.07600747
113MP0005174_abnormal_tail_pigmentation1.07373527
114MP0002108_abnormal_muscle_morphology1.06438631
115MP0000350_abnormal_cell_proliferation1.05821565
116MP0004087_abnormal_muscle_fiber1.03912985
117MP0005058_abnormal_lysosome_morphology1.03412694
118MP0001849_ear_inflammation1.02653339
119MP0002085_abnormal_embryonic_tissue1.02397679
120MP0000733_abnormal_muscle_development1.00534713
121MP0001730_embryonic_growth_arrest1.00520956
122MP0002116_abnormal_craniofacial_bone0.97855472
123MP0002295_abnormal_pulmonary_circulatio0.97387674
124MP0001243_abnormal_dermal_layer0.97143959
125MP0005666_abnormal_adipose_tissue0.97031028
126MP0005377_hearing/vestibular/ear_phenot0.96629122
127MP0003878_abnormal_ear_physiology0.96629122
128MP0002269_muscular_atrophy0.96090948
129MP0002084_abnormal_developmental_patter0.95367633
130MP0008775_abnormal_heart_ventricle0.95297786
131MP0008932_abnormal_embryonic_tissue0.94817785
132MP0002127_abnormal_cardiovascular_syste0.94782917
133MP0004134_abnormal_chest_morphology0.93546824
134MP0002114_abnormal_axial_skeleton0.93291122
135MP0002115_abnormal_skeleton_extremities0.92657757
136MP0003385_abnormal_body_wall0.92493967
137MP0003950_abnormal_plasma_membrane0.91834484
138MP0003091_abnormal_cell_migration0.90454440
139MP0005390_skeleton_phenotype0.90427228
140MP0002086_abnormal_extraembryonic_tissu0.90230220
141MP0006292_abnormal_olfactory_placode0.90200068
142MP0000569_abnormal_digit_pigmentation0.89261618
143MP0001293_anophthalmia0.88372612
144MP0003077_abnormal_cell_cycle0.86842244
145MP0000759_abnormal_skeletal_muscle0.86711401
146MP0000383_abnormal_hair_follicle0.86005529
147MP0008789_abnormal_olfactory_epithelium0.85635528
148MP0003656_abnormal_erythrocyte_physiolo0.85329368
149MP0005423_abnormal_somatic_nervous0.85024184
150MP0004036_abnormal_muscle_relaxation0.83762526
151MP0002896_abnormal_bone_mineralization0.83568248
152MP0002109_abnormal_limb_morphology0.83034549
153MP0003942_abnormal_urinary_system0.82618083
154MP0005253_abnormal_eye_physiology0.80376358
155MP0005636_abnormal_mineral_homeostasis0.76342755
156MP0002090_abnormal_vision0.75024844
157MP0001764_abnormal_homeostasis0.74972759
158MP0004885_abnormal_endolymph0.72129309
159MP0005551_abnormal_eye_electrophysiolog0.71031168
160MP0003690_abnormal_glial_cell0.70054036
161MP0002132_abnormal_respiratory_system0.69014750
162* MP0000647_abnormal_sebaceous_gland0.67591583
163MP0001324_abnormal_eye_pigmentation0.62649184
164MP0002249_abnormal_larynx_morphology0.61944055
165MP0000639_abnormal_adrenal_gland0.58234577
166* MP0000377_abnormal_hair_follicle0.58043979
167MP0000358_abnormal_cell_content/0.57970535

Predicted human phenotypes

RankGene SetZ-score
1Cholecystitis (HP:0001082)7.02420936
2Abnormal gallbladder physiology (HP:0012438)7.02420936
3Irregular epiphyses (HP:0010582)4.62875426
4Reticulocytosis (HP:0001923)4.55018972
5Protrusio acetabuli (HP:0003179)4.41331717
6Premature rupture of membranes (HP:0001788)4.30645475
7Neonatal short-limb short stature (HP:0008921)4.26169345
8Ectropion (HP:0000656)4.19997693
9Truncus arteriosus (HP:0001660)4.18414018
10Alopecia of scalp (HP:0002293)4.09537240
11Intrahepatic cholestasis (HP:0001406)3.97107898
12Abnormality of glycolysis (HP:0004366)3.89769468
13Increased serum pyruvate (HP:0003542)3.64897795
14Increased connective tissue (HP:0009025)3.56010754
15Flat capital femoral epiphysis (HP:0003370)3.54884753
16Hypoplastic pelvis (HP:0008839)3.51140863
17Cortical dysplasia (HP:0002539)3.48260245
18Epiphyseal dysplasia (HP:0002656)3.40342913
19Abnormal gallbladder morphology (HP:0012437)3.32256919
20Abnormality of reticulocytes (HP:0004312)3.24842556
21Hyperglycinemia (HP:0002154)3.22563602
22Spontaneous abortion (HP:0005268)3.22127366
23Hypoplastic ischia (HP:0003175)3.19590155
24Flat acetabular roof (HP:0003180)3.19436141
25Polycythemia (HP:0001901)3.18209412
26Hypoalphalipoproteinemia (HP:0003233)3.17187456
27Cholelithiasis (HP:0001081)3.16135552
28Disproportionate tall stature (HP:0001519)3.12284948
29Cupped ribs (HP:0000887)3.11768196
30Chronic hepatic failure (HP:0100626)3.09691951
31Metaphyseal cupping (HP:0003021)3.06109902
32Entropion (HP:0000621)2.97328427
33Ankle contracture (HP:0006466)2.96103840
34Atelectasis (HP:0100750)2.91016882
35Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.86939352
36Ileus (HP:0002595)2.83939244
37Vitreoretinal degeneration (HP:0000655)2.76140826
38Small epiphyses (HP:0010585)2.75599260
39Bilateral microphthalmos (HP:0007633)2.73886109
40Abnormality of the ischium (HP:0003174)2.72448589
41Muscle fiber splitting (HP:0003555)2.71910024
42Hip contracture (HP:0003273)2.69781057
43Hyperbilirubinemia (HP:0002904)2.68036545
44Peripheral hypomyelination (HP:0007182)2.67791075
45Breech presentation (HP:0001623)2.66681339
46Abnormality of the gallbladder (HP:0005264)2.65407572
47Carpal bone hypoplasia (HP:0001498)2.63871942
48White forelock (HP:0002211)2.62792812
49Abnormal cartilage morphology (HP:0002763)2.60984834
50Hand muscle atrophy (HP:0009130)2.60223685
51Abnormality of the aortic arch (HP:0012303)2.57540713
52Multiple enchondromatosis (HP:0005701)2.57423828
53Cervical subluxation (HP:0003308)2.57277993
54Genu varum (HP:0002970)2.57084717
55Difficulty climbing stairs (HP:0003551)2.53371775
56Seborrheic dermatitis (HP:0001051)2.53206513
57Genu recurvatum (HP:0002816)2.52736869
58Patchy hypopigmentation of hair (HP:0011365)2.52096579
59Abnormal vertebral ossification (HP:0100569)2.50293253
60Mildly elevated creatine phosphokinase (HP:0008180)2.50263727
61Flattened epiphyses (HP:0003071)2.44778680
62Abnormality of the pubic bones (HP:0003172)2.44310286
63Premature skin wrinkling (HP:0100678)2.43161012
64Abnormality of the distal phalanx of the thumb (HP:0009617)2.40541668
65Right ventricular cardiomyopathy (HP:0011663)2.38957803
66Abnormal delivery (HP:0001787)2.38452829
67Congenital primary aphakia (HP:0007707)2.38074144
68Bowel incontinence (HP:0002607)2.37014871
69Trismus (HP:0000211)2.34418722
70Atrophic scars (HP:0001075)2.34142022
71Osteoarthritis (HP:0002758)2.34030203
72Distal upper limb amyotrophy (HP:0007149)2.33753310
73Upper limb amyotrophy (HP:0009129)2.33753310
74Hypolipoproteinemia (HP:0010981)2.33635235
75Hypoplasia of the iris (HP:0007676)2.32571254
76Nephrogenic diabetes insipidus (HP:0009806)2.31432609
77Spinal cord compression (HP:0002176)2.31388104
78Poikiloderma (HP:0001029)2.30001170
79Glossoptosis (HP:0000162)2.29546213
80Delayed epiphyseal ossification (HP:0002663)2.28627605
81Gait imbalance (HP:0002141)2.28599435
82Distal lower limb muscle weakness (HP:0009053)2.28291498
83Poor coordination (HP:0002370)2.27811985
84Coxa vara (HP:0002812)2.27104403
85Abnormality of the distal phalanges of the toes (HP:0010182)2.26710285
86Abnormality of femoral epiphyses (HP:0006499)2.26506074
87Abnormality involving the epiphyses of the lower limbs (HP:0006500)2.26506074
88Mild short stature (HP:0003502)2.25174643
89Ventricular tachycardia (HP:0004756)2.24539540
90Limited hip movement (HP:0008800)2.20973924
91Abnormality of the proximal phalanges of the hand (HP:0009834)2.17813655
92Difficulty running (HP:0009046)2.16732345
93Vertebral clefting (HP:0008428)2.15086438
94Abnormal large intestine physiology (HP:0012700)2.14946044
95Type 1 muscle fiber predominance (HP:0003803)2.13935763
96Neonatal onset (HP:0003623)2.12937468
97Fused cervical vertebrae (HP:0002949)2.11790045
98Wrist flexion contracture (HP:0001239)2.10528024
99Acanthocytosis (HP:0001927)2.10356958
100Aplasia/hypoplasia of the humerus (HP:0006507)2.10276061
101Epidermoid cyst (HP:0200040)2.09588336
102Soft skin (HP:0000977)2.08539806
103Abnormality of the acetabulum (HP:0003170)2.07821428
104Rib fusion (HP:0000902)2.07016058
105Abnormality of the epiphysis of the femoral head (HP:0010574)2.06079758
106Abnormally folded helix (HP:0008544)2.05290681
107Keratitis (HP:0000491)2.05251231
108Onycholysis (HP:0001806)2.04141353
109Acute encephalopathy (HP:0006846)2.03160450
110Medial flaring of the eyebrow (HP:0010747)2.02606701
111Short humerus (HP:0005792)2.02380144
112Mesomelia (HP:0003027)2.02209188
113Shallow orbits (HP:0000586)2.01811269
114Peritonitis (HP:0002586)2.00756785
115Severe Myopia (HP:0011003)1.99982651
116Hyperthyroidism (HP:0000836)1.99920986
117Platyspondyly (HP:0000926)1.98756142
118Ependymoma (HP:0002888)1.98018983
119Abnormality of the tricuspid valve (HP:0001702)1.95723302
120Short middle phalanx of finger (HP:0005819)1.95532950
121Hepatoblastoma (HP:0002884)1.95208307
122Abnormal tarsal ossification (HP:0008369)1.94779619
123Hammertoe (HP:0001765)1.93940889
124Stillbirth (HP:0003826)1.91857037
125Anteriorly placed anus (HP:0001545)1.91647524
126Selective tooth agenesis (HP:0001592)1.91291171
127Pancreatic fibrosis (HP:0100732)1.91089203
128Spinal rigidity (HP:0003306)1.89751081
129* Abnormality of nail color (HP:0100643)1.89409884
130Aortic dissection (HP:0002647)1.88945375
131Wide anterior fontanel (HP:0000260)1.88735042
132Aplasia/Hypoplasia of the middle phalanges of the hand (HP:0009843)1.87063772
133Ulnar bowing (HP:0003031)1.86607842
134Short 5th finger (HP:0009237)1.85736273
135Breast hypoplasia (HP:0003187)1.84190940
136Occipital encephalocele (HP:0002085)1.83877117
137Nail dystrophy (HP:0008404)1.83698290
138Testicular atrophy (HP:0000029)1.83655919
139Limited elbow extension (HP:0001377)1.83601892
140Abnormal hemoglobin (HP:0011902)1.83552463
141Hypertensive crisis (HP:0100735)1.83410839
142Abnormality of carpal bone ossification (HP:0006257)1.82889670
143Abnormality of the umbilical cord (HP:0010881)1.81285663
144Flat cornea (HP:0007720)1.81028669
145Poikilocytosis (HP:0004447)1.81005212
146Broad palm (HP:0001169)1.80915882
147Absent epiphyses (HP:0010577)1.80444488
148Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.80444488
149Aplasia/Hypoplasia of the scapulae (HP:0006713)1.80368000
150Hypoplastic scapulae (HP:0000882)1.80368000
151Abnormality of the femoral head (HP:0003368)1.79875201
152Exercise-induced muscle cramps (HP:0003710)1.79313278
153Aplasia/Hypoplasia of the lens (HP:0008063)1.78686598
154True hermaphroditism (HP:0010459)1.78534506
155Abnormality of dentin (HP:0010299)1.77932298
156Amyloidosis (HP:0011034)1.77475785
157Upper limb muscle weakness (HP:0003484)1.75926691
158Hypoparathyroidism (HP:0000829)1.75481405
159Blue sclerae (HP:0000592)1.75312628
160Shawl scrotum (HP:0000049)1.74585190
161Hyperammonemia (HP:0001987)1.73582944
162Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.73368128
163Fat malabsorption (HP:0002630)1.72770097
164Abnormality of the musculature of the hand (HP:0001421)1.72745929
165Sensorimotor neuropathy (HP:0007141)1.72084349
166Abnormality of the calcaneus (HP:0008364)1.71147875
167Aortic aneurysm (HP:0004942)1.70218332
168Abnormal ossification of hand bones (HP:0005921)1.69332432
169Follicular hyperkeratosis (HP:0007502)1.68971966
170Broad long bones (HP:0005622)1.68733702
171Abnormality of dental color (HP:0011073)1.68685812
172Thin ribs (HP:0000883)1.68487372
173Dry hair (HP:0011359)1.67916532
174Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.66047723
175Congenital ichthyosiform erythroderma (HP:0007431)1.65698293
176Cheekbone underdevelopment (HP:0010669)1.65580999
177Abnormal hair laboratory examination (HP:0003328)1.63902980
178Hepatocellular necrosis (HP:0001404)1.63059226
179Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.62869102
180Bladder diverticulum (HP:0000015)1.61440262
181Erythroderma (HP:0001019)1.60592411
182Xanthomatosis (HP:0000991)1.57716457
183Fragile nails (HP:0001808)1.56947503
184Vaginal atresia (HP:0000148)1.56860880
185Cutaneous melanoma (HP:0012056)1.56027438
186Spastic paraparesis (HP:0002313)1.54773350
187Decreased lacrimation (HP:0000633)1.54671732
188Genital tract atresia (HP:0001827)1.52433373

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA24.29727116
2CDK124.20279819
3DDR23.25851338
4STK38L3.14031023
5EPHB12.70936839
6EPHB22.61106950
7ERN12.50253905
8TTN2.48997795
9TRIB32.45249131
10BUB12.43773134
11GRK52.28369998
12LATS22.25135670
13TTK2.17205364
14EPHA32.16649767
15BCR2.12924533
16SIK32.04880829
17CDK191.97386512
18MAP3K31.96105102
19EPHA41.93182633
20NEK11.88907607
21RIPK41.84652796
22RIPK11.79996014
23GRK61.79112141
24WEE11.74491295
25KSR21.70234733
26CLK11.69980171
27DYRK1B1.67008333
28PAK41.58830410
29NTRK31.56750581
30MAP3K21.53884528
31KSR11.52806067
32PDGFRA1.51738124
33TYRO31.49534501
34NME11.48860041
35PDK21.38262758
36LRRK21.38071663
37CCNB11.35442677
38PINK11.35028901
39GRK11.31429176
40PDK41.25994003
41PDK31.25994003
42LATS11.25835049
43TRIM281.23771777
44PRKG21.23648288
45RPS6KB21.21854016
46MARK31.17490688
47TSSK61.14791735
48CDK71.13668028
49MAP3K41.13272741
50MAPK151.13038992
51MAPKAPK31.12537295
52MAP3K71.11586114
53PBK1.10001822
54MAP3K61.09061311
55NEK21.07616926
56MAPK71.07513213
57PLK11.07486569
58PTK21.07467092
59TNIK1.06338886
60TAOK21.06306604
61PTK61.06117842
62LMTK21.04228607
63FER1.03724330
64MOS1.03339231
65STK241.02574767
66TAOK11.01063470
67ROCK21.00394547
68AKT30.99853807
69STK100.96286916
70MET0.95403816
71PRKCI0.95128358
72PAK30.94846406
73PRKD20.92574714
74MTOR0.91228116
75MAPK130.89999605
76STK30.89751567
77PKN20.88240687
78TESK10.83469031
79CHEK20.81897274
80MYLK0.81878094
81FLT30.81506476
82TGFBR20.81279260
83RET0.80439353
84EIF2AK10.78520960
85PAK10.78417793
86ADRBK20.76957443
87BRD40.76775141
88MARK20.76655810
89NTRK20.76644894
90WNK10.76290753
91PHKG10.76205845
92PHKG20.76205845
93STK40.74310311
94TESK20.72826307
95TYK20.72717030
96JAK20.72700365
97NEK60.72514036
98RPS6KA40.72114620
99FGFR10.71465964
100FGFR40.71348910
101MARK10.68832133
102AURKB0.64937765
103PAK20.63659767
104AURKA0.62911481
105DYRK30.62413470
106RAF10.62324200
107PRKD30.61830592
108STK380.61113046
109ZAK0.60491529
110PLK40.59469234
111PKN10.56616739
112SIK10.56110533
113AKT20.55731597
114MAP3K100.54303541
115MATK0.53847379
116WNK40.53392637
117PIM20.53380033
118ICK0.53307230
119MST1R0.52686122
120ALK0.51989587
121MAPK120.51899893
122ADRBK10.51808206
123MST40.50891308
124CSF1R0.50641238
125MAP2K10.50566816
126PRKACB0.49837957
127PTK2B0.49418683
128MAP2K20.49271114
129PLK30.49042192
130ILK0.48592850
131PRKD10.47888691
132PIK3CG0.47840855
133ROCK10.47808170
134EIF2AK20.46616571
135OBSCN0.46537193
136GRK70.45985245
137PAK60.45730286
138CAMK40.45538430
139PASK0.45485957
140CHEK10.45234025
141BCKDK0.44236836
142ERBB20.40951892
143SRPK10.40772399
144PRKACG0.40253131
145MAP3K80.39796199
146TNK20.39406952
147CASK0.39396007
148NME20.39142015
149LIMK10.39013608
150BMX0.38123970
151NTRK10.37602557
152TAOK30.36723659
153MAP2K70.35778984
154CSNK1E0.35211724
155DYRK20.34125911
156JAK30.33014332
157SRC0.32870981
158PRKAA10.31459569
159PDGFRB0.31346015
160SGK2230.28614820
161SGK4940.28614820
162BRSK10.27619732
163DYRK1A0.27465625
164MKNK10.26688868

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000724.43896663
2Steroid biosynthesis_Homo sapiens_hsa001003.32993811
3Primary bile acid biosynthesis_Homo sapiens_hsa001203.18577476
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.10309858
5Butirosin and neomycin biosynthesis_Homo sapiens_hsa005243.06234771
6ECM-receptor interaction_Homo sapiens_hsa045123.02820955
7Fructose and mannose metabolism_Homo sapiens_hsa000512.73290730
8Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.72220487
9Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.71273265
10Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.40076911
11Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.36584234
12Proteasome_Homo sapiens_hsa030502.29223025
13Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005202.26679490
14Fatty acid elongation_Homo sapiens_hsa000622.24430642
15Protein digestion and absorption_Homo sapiens_hsa049742.21578545
16RNA transport_Homo sapiens_hsa030132.17488171
17Hippo signaling pathway_Homo sapiens_hsa043902.16310171
18Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.10303472
19Propanoate metabolism_Homo sapiens_hsa006402.09796058
20Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.09064916
21Butanoate metabolism_Homo sapiens_hsa006502.05108040
22Pyruvate metabolism_Homo sapiens_hsa006202.04418884
23Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.02969526
24Basal cell carcinoma_Homo sapiens_hsa052172.02889376
25Hedgehog signaling pathway_Homo sapiens_hsa043402.01448037
262-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.97620121
27Nitrogen metabolism_Homo sapiens_hsa009101.95761110
28Vitamin B6 metabolism_Homo sapiens_hsa007501.90002110
29Cyanoamino acid metabolism_Homo sapiens_hsa004601.89214968
30Galactose metabolism_Homo sapiens_hsa000521.84791815
31Fatty acid metabolism_Homo sapiens_hsa012121.82543696
32Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.81267299
33Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.81026850
34Focal adhesion_Homo sapiens_hsa045101.80358172
35Arginine biosynthesis_Homo sapiens_hsa002201.75152835
36Other glycan degradation_Homo sapiens_hsa005111.69993433
37Dilated cardiomyopathy_Homo sapiens_hsa054141.69758372
38Cell cycle_Homo sapiens_hsa041101.64811010
39Arachidonic acid metabolism_Homo sapiens_hsa005901.61670715
40Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.61404239
41Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.57318933
42Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.55051535
43Tight junction_Homo sapiens_hsa045301.54655973
44RNA polymerase_Homo sapiens_hsa030201.53647446
45Adherens junction_Homo sapiens_hsa045201.52228336
46p53 signaling pathway_Homo sapiens_hsa041151.51382960
47Proteoglycans in cancer_Homo sapiens_hsa052051.48112922
48Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.35373838
49TGF-beta signaling pathway_Homo sapiens_hsa043501.35006003
50PPAR signaling pathway_Homo sapiens_hsa033201.33578633
51Arginine and proline metabolism_Homo sapiens_hsa003301.33565426
52Central carbon metabolism in cancer_Homo sapiens_hsa052301.32550249
53MicroRNAs in cancer_Homo sapiens_hsa052061.26365694
54Peroxisome_Homo sapiens_hsa041461.26258774
55Bladder cancer_Homo sapiens_hsa052191.24527138
56mTOR signaling pathway_Homo sapiens_hsa041501.17998766
57Oxidative phosphorylation_Homo sapiens_hsa001901.13383409
58Carbon metabolism_Homo sapiens_hsa012001.12389273
59Ribosome_Homo sapiens_hsa030101.12198924
60Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.10975551
61Spliceosome_Homo sapiens_hsa030401.09154006
62Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.06647296
63PI3K-Akt signaling pathway_Homo sapiens_hsa041511.05879371
64Small cell lung cancer_Homo sapiens_hsa052221.05094280
65HIF-1 signaling pathway_Homo sapiens_hsa040661.04837150
66Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.04626347
67Regulation of autophagy_Homo sapiens_hsa041401.04108786
68Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.02296463
69Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.00171942
70Vitamin digestion and absorption_Homo sapiens_hsa049770.99406974
71Linoleic acid metabolism_Homo sapiens_hsa005910.98451041
72Cardiac muscle contraction_Homo sapiens_hsa042600.97768151
73alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.95875813
74Parkinsons disease_Homo sapiens_hsa050120.93303009
75Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.91497700
76Regulation of actin cytoskeleton_Homo sapiens_hsa048100.91326493
77Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.89927178
78Biosynthesis of amino acids_Homo sapiens_hsa012300.88661479
79Pathways in cancer_Homo sapiens_hsa052000.87244429
80Thyroid cancer_Homo sapiens_hsa052160.85109373
81Fatty acid degradation_Homo sapiens_hsa000710.83962020
82Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.80198287
83DNA replication_Homo sapiens_hsa030300.78576743
84Huntingtons disease_Homo sapiens_hsa050160.77065006
85HTLV-I infection_Homo sapiens_hsa051660.76568081
86Amoebiasis_Homo sapiens_hsa051460.75171330
87Cysteine and methionine metabolism_Homo sapiens_hsa002700.73585547
88Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.73150910
89Melanoma_Homo sapiens_hsa052180.71368329
90Pentose phosphate pathway_Homo sapiens_hsa000300.70844198
91Wnt signaling pathway_Homo sapiens_hsa043100.70332652
92Notch signaling pathway_Homo sapiens_hsa043300.69779800
93* Thyroid hormone signaling pathway_Homo sapiens_hsa049190.69313326
94Longevity regulating pathway - mammal_Homo sapiens_hsa042110.69102396
95* Metabolic pathways_Homo sapiens_hsa011000.67837082
96Leukocyte transendothelial migration_Homo sapiens_hsa046700.67611258
97Collecting duct acid secretion_Homo sapiens_hsa049660.67492431
98One carbon pool by folate_Homo sapiens_hsa006700.65980635
99Retinol metabolism_Homo sapiens_hsa008300.65628922
100AMPK signaling pathway_Homo sapiens_hsa041520.65412083
101Folate biosynthesis_Homo sapiens_hsa007900.65410614
102mRNA surveillance pathway_Homo sapiens_hsa030150.65021346
103Pyrimidine metabolism_Homo sapiens_hsa002400.62801698
104Mismatch repair_Homo sapiens_hsa034300.62475509
105Glycosaminoglycan degradation_Homo sapiens_hsa005310.62396809
106Glycerophospholipid metabolism_Homo sapiens_hsa005640.60973954
107Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.59448800
108Legionellosis_Homo sapiens_hsa051340.59026419
109* AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.58822163
110Oocyte meiosis_Homo sapiens_hsa041140.57467637
111Epstein-Barr virus infection_Homo sapiens_hsa051690.57397884
112Mineral absorption_Homo sapiens_hsa049780.55483634
113Renin-angiotensin system_Homo sapiens_hsa046140.55286298
114Lysine degradation_Homo sapiens_hsa003100.55185120
115Rap1 signaling pathway_Homo sapiens_hsa040150.53732710
116Vibrio cholerae infection_Homo sapiens_hsa051100.51437506
117Renal cell carcinoma_Homo sapiens_hsa052110.51102867
118Sphingolipid metabolism_Homo sapiens_hsa006000.50626339
119Base excision repair_Homo sapiens_hsa034100.50429413
120Fat digestion and absorption_Homo sapiens_hsa049750.50096973
121Apoptosis_Homo sapiens_hsa042100.50019728
122Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.47857992
123VEGF signaling pathway_Homo sapiens_hsa043700.47790142
124Malaria_Homo sapiens_hsa051440.46372397
125Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.44727199
126Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.44658743
127RNA degradation_Homo sapiens_hsa030180.44547996
128Nucleotide excision repair_Homo sapiens_hsa034200.44045419
129Protein export_Homo sapiens_hsa030600.42176165
130Basal transcription factors_Homo sapiens_hsa030220.41875650
131Ether lipid metabolism_Homo sapiens_hsa005650.41530786
132Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.40913244
133Viral myocarditis_Homo sapiens_hsa054160.39295368
134Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.39114489
135Prostate cancer_Homo sapiens_hsa052150.36055471
136Glycerolipid metabolism_Homo sapiens_hsa005610.35521919
137Viral carcinogenesis_Homo sapiens_hsa052030.34618956
138SNARE interactions in vesicular transport_Homo sapiens_hsa041300.34279272
139Alzheimers disease_Homo sapiens_hsa050100.34218392
140Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.34208754
141Sulfur relay system_Homo sapiens_hsa041220.33382194
142Insulin resistance_Homo sapiens_hsa049310.33105516
143Glutathione metabolism_Homo sapiens_hsa004800.32692143
144Axon guidance_Homo sapiens_hsa043600.32574024
145Fanconi anemia pathway_Homo sapiens_hsa034600.31073196
146Endocytosis_Homo sapiens_hsa041440.30895636
147Endometrial cancer_Homo sapiens_hsa052130.30893384
148Phospholipase D signaling pathway_Homo sapiens_hsa040720.30599456
149Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.30309545
150Shigellosis_Homo sapiens_hsa051310.30218217
151Homologous recombination_Homo sapiens_hsa034400.30041953
152N-Glycan biosynthesis_Homo sapiens_hsa005100.29926341
153Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.29387794
154Chemical carcinogenesis_Homo sapiens_hsa052040.27363272
155Steroid hormone biosynthesis_Homo sapiens_hsa001400.26454137
156Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.26183422
157Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.23932944
158Pentose and glucuronate interconversions_Homo sapiens_hsa000400.23869098
159Choline metabolism in cancer_Homo sapiens_hsa052310.21319971
160Olfactory transduction_Homo sapiens_hsa047400.20308631
161Acute myeloid leukemia_Homo sapiens_hsa052210.17937096
162Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.13137152
163Tyrosine metabolism_Homo sapiens_hsa003500.12860233

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