PLCD3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the phospholipase C family, which catalyze the hydrolysis of phosphatidylinositol 4,5-bisphosphate to generate the second messengers diacylglycerol and inositol 1,4,5-trisphosphate (IP3). Diacylglycerol and IP3 mediate a variety of cellular responses to extracellular stimuli by inducing protein kinase C and increasing cytosolic Ca(2+) concentrations. This enzyme localizes to the plasma membrane and requires calcium for activation. Its activity is inhibited by spermine, sphingosine, and several phospholipids. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of hippo signaling (GO:0035330)4.49329304
2hemidesmosome assembly (GO:0031581)4.19139605
3plasma membrane repair (GO:0001778)4.16578348
4epithelial cell-cell adhesion (GO:0090136)4.02699848
5intestinal epithelial cell development (GO:0060576)4.02598153
6regulation of G0 to G1 transition (GO:0070316)4.00445268
7negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.97383245
8lung-associated mesenchyme development (GO:0060484)3.93278715
9regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.68148975
10hippo signaling (GO:0035329)3.56219201
11regulation of posttranscriptional gene silencing (GO:0060147)3.55776212
12regulation of gene silencing by miRNA (GO:0060964)3.55776212
13regulation of gene silencing by RNA (GO:0060966)3.55776212
14establishment of apical/basal cell polarity (GO:0035089)3.52119208
15sarcomere organization (GO:0045214)3.50877962
16cell-substrate junction assembly (GO:0007044)3.45880628
17labyrinthine layer development (GO:0060711)3.42563075
18polarized epithelial cell differentiation (GO:0030859)3.41974446
19paraxial mesoderm development (GO:0048339)3.41612502
20interferon-gamma secretion (GO:0072643)3.40409437
21trophectodermal cell differentiation (GO:0001829)3.39993676
22anterior/posterior axis specification, embryo (GO:0008595)3.39208098
23regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.38595023
24formation of translation preinitiation complex (GO:0001731)3.34349050
25activation of Rac GTPase activity (GO:0032863)3.33491159
26bundle of His cell to Purkinje myocyte communication (GO:0086069)3.32696313
27regulation of cardioblast differentiation (GO:0051890)3.31172997
28cardiac muscle cell development (GO:0055013)3.30861837
29negative regulation of potassium ion transmembrane transport (GO:1901380)3.29996446
30ribosome assembly (GO:0042255)3.29766026
31ventricular cardiac muscle cell action potential (GO:0086005)3.27799326
32positive regulation of fatty acid beta-oxidation (GO:0032000)3.27707526
33regulation of SMAD protein import into nucleus (GO:0060390)3.27115649
34apoptotic process involved in morphogenesis (GO:0060561)3.25840430
35positive regulation of SMAD protein import into nucleus (GO:0060391)3.20805492
36adherens junction assembly (GO:0034333)3.17243134
37vitamin transmembrane transport (GO:0035461)3.16139016
38heterochromatin organization (GO:0070828)3.15690567
39ectoderm development (GO:0007398)3.11195962
40cardiac cell development (GO:0055006)3.09949538
41cell-substrate adherens junction assembly (GO:0007045)3.03859775
42focal adhesion assembly (GO:0048041)3.03859775
43regulation of tight junction assembly (GO:2000810)3.02692515
44negative regulation of catenin import into nucleus (GO:0035414)3.01600102
45planar cell polarity pathway involved in neural tube closure (GO:0090179)2.98733476
46apoptotic process involved in development (GO:1902742)2.98645424
47renal filtration (GO:0097205)2.98397005
48regulation of fatty acid beta-oxidation (GO:0031998)2.97075515
49mitotic G1 DNA damage checkpoint (GO:0031571)2.96219577
50ectodermal placode formation (GO:0060788)2.95448465
51notochord development (GO:0030903)2.94700674
52semaphorin-plexin signaling pathway (GO:0071526)2.90327691
53establishment of monopolar cell polarity (GO:0061162)2.89738450
54establishment or maintenance of monopolar cell polarity (GO:0061339)2.89738450
55protein hydroxylation (GO:0018126)2.89276803
56endothelial cell morphogenesis (GO:0001886)2.88771180
57purine nucleobase biosynthetic process (GO:0009113)2.88028500
58protein localization to kinetochore (GO:0034501)2.88001032
59negative regulation of chondrocyte differentiation (GO:0032331)2.87789603
60cardiac myofibril assembly (GO:0055003)2.87418659
61GMP metabolic process (GO:0046037)2.86436130
62desmosome organization (GO:0002934)2.85939465
63branching involved in salivary gland morphogenesis (GO:0060445)2.85932479
64regulation of translational fidelity (GO:0006450)2.85578291
65negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.83491758
66positive regulation of fatty acid oxidation (GO:0046321)2.83383869
67regulation of spindle organization (GO:0090224)2.81917787
68atrioventricular valve morphogenesis (GO:0003181)2.80402187
69cytoskeletal anchoring at plasma membrane (GO:0007016)2.77874164
70peptidyl-proline hydroxylation (GO:0019511)2.77225099
71regulation of mitotic spindle organization (GO:0060236)2.76850391
72negative regulation of cell size (GO:0045792)2.75795519
73CDP-diacylglycerol metabolic process (GO:0046341)2.74505156
74regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.73796132
75ventricular cardiac muscle cell development (GO:0055015)2.73177308
76NADH metabolic process (GO:0006734)2.71762426
77regulation of translational termination (GO:0006449)2.66756492
78nucleobase biosynthetic process (GO:0046112)2.65320433
79folic acid transport (GO:0015884)2.64984216
80gap junction assembly (GO:0016264)2.64017716
81regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.63540627
82glomerular basement membrane development (GO:0032836)2.60500498
83mitotic metaphase plate congression (GO:0007080)2.58758294
84skeletal muscle adaptation (GO:0043501)2.57341982
85cell junction maintenance (GO:0034331)2.56514451
86cellular senescence (GO:0090398)2.55867748
87spindle assembly involved in mitosis (GO:0090307)2.53889046
88ribosome biogenesis (GO:0042254)2.53020184
89cell-cell junction maintenance (GO:0045217)2.51711376
90outflow tract septum morphogenesis (GO:0003148)2.50705346
91regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901212.49757947
92regulation of apoptotic process involved in morphogenesis (GO:1902337)2.48658404
93regulation of fatty acid oxidation (GO:0046320)2.48461748
94folic acid metabolic process (GO:0046655)2.47732837
95actin-mediated cell contraction (GO:0070252)2.46571855
96hypotonic response (GO:0006971)2.45800678
97actomyosin structure organization (GO:0031032)2.44953367
98muscle cell migration (GO:0014812)2.44047123
99branching involved in mammary gland duct morphogenesis (GO:0060444)2.42675843
100mitotic nuclear envelope disassembly (GO:0007077)2.40659873
101stress fiber assembly (GO:0043149)2.40188105
102mitotic G1/S transition checkpoint (GO:0044819)2.40154254
103positive regulation of synapse maturation (GO:0090129)2.39796694
104NLS-bearing protein import into nucleus (GO:0006607)2.39363926
105nuclear pore organization (GO:0006999)2.38889066
106protein retention in ER lumen (GO:0006621)2.38562633
107positive regulation of chromosome segregation (GO:0051984)2.37886403
108keratinocyte proliferation (GO:0043616)2.37710857
109regulation of skeletal muscle contraction (GO:0014819)2.36903731
110positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.36790671
111regulation of the force of heart contraction (GO:0002026)2.36009684
112G1 DNA damage checkpoint (GO:0044783)2.35302421
113negative regulation of protein localization to cell surface (GO:2000009)2.34109757
114cell migration involved in sprouting angiogenesis (GO:0002042)2.33910483
115establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.33814709
116nuclear envelope disassembly (GO:0051081)2.33171268
117membrane disassembly (GO:0030397)2.33171268
118positive regulation of osteoblast proliferation (GO:0033690)2.32220716
119nuclear envelope organization (GO:0006998)2.31950302
120cochlea morphogenesis (GO:0090103)2.31692103
121actin-myosin filament sliding (GO:0033275)2.31459579
122muscle filament sliding (GO:0030049)2.31459579
123embryonic skeletal joint morphogenesis (GO:0060272)2.31375698
124regulation of translation in response to stress (GO:0043555)2.30924530
125response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.30906607
126negative regulation of cartilage development (GO:0061037)2.30663419
127negative regulation of keratinocyte proliferation (GO:0010839)2.30638400
128negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.30462947
129regulation of striated muscle cell apoptotic process (GO:0010662)2.30178014
130type B pancreatic cell proliferation (GO:0044342)2.29828034
131regulation of early endosome to late endosome transport (GO:2000641)2.29818652
132transcription from mitochondrial promoter (GO:0006390)2.29458849
133histone H2A monoubiquitination (GO:0035518)2.29313148
134regulation of clathrin-mediated endocytosis (GO:2000369)2.29173328
135fibroblast migration (GO:0010761)2.29096490
136skin morphogenesis (GO:0043589)2.28024681
137maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.27875276
138synaptic vesicle docking involved in exocytosis (GO:0016081)2.27587154
139Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.26997092
140protein heterotrimerization (GO:0070208)2.24137788
141myelin maintenance (GO:0043217)2.23723192
142skeletal muscle contraction (GO:0003009)2.23034486
143regulation of pseudopodium assembly (GO:0031272)2.23007670
144L-serine transport (GO:0015825)2.22912473
145endothelial cell chemotaxis (GO:0035767)2.21874275
146lung epithelium development (GO:0060428)2.21546272
147kidney mesenchyme development (GO:0072074)2.19339198
148myoblast fusion (GO:0007520)2.18801172
149sodium ion export (GO:0071436)2.18256564
150cell junction assembly (GO:0034329)2.17766130
151GDP-mannose metabolic process (GO:0019673)2.16820701
152regulation of glomerular filtration (GO:0003093)2.16427271
153neuromuscular junction development (GO:0007528)2.16336707
154renal system development (GO:0072001)2.16051493
155positive regulation of triglyceride biosynthetic process (GO:0010867)2.13245759
156positive regulation of establishment of protein localization to plasma membrane (GO:0090004)2.13244640
157regulation of glucose import in response to insulin stimulus (GO:2001273)2.11529940
158lung vasculature development (GO:0060426)2.09766039
159glycogen catabolic process (GO:0005980)2.09022697
160osteoblast development (GO:0002076)2.08706591
161regulation of establishment of planar polarity (GO:0090175)2.08694331
162response to food (GO:0032094)2.08577319
163white fat cell differentiation (GO:0050872)2.08110713
164dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.08100510
165skeletal muscle fiber development (GO:0048741)2.07636077
166peripheral nervous system axon ensheathment (GO:0032292)2.07307627
167myelination in peripheral nervous system (GO:0022011)2.07307627
168embryonic eye morphogenesis (GO:0048048)2.07030657
169mesodermal cell differentiation (GO:0048333)2.06195423

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human4.74950517
2* ZNF263_19887448_ChIP-Seq_K562_Human3.13293725
3NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.74630330
4POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.69263840
5FOXM1_23109430_ChIP-Seq_U2OS_Human2.67968838
6TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.56173569
7KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.54095338
8KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.54095338
9KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.54095338
10* RARG_19884340_ChIP-ChIP_MEFs_Mouse2.51022887
11SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.37335498
12SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.29135586
13* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.22183957
14NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.13520109
15PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.13472506
16THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.12155464
17STAT3_1855785_ChIP-Seq_MESCs_Mouse2.10546469
18* KLF4_18358816_ChIP-ChIP_MESCs_Mouse2.08820605
19MYC_18555785_ChIP-Seq_MESCs_Mouse2.08448047
20ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.07456426
21ESR2_21235772_ChIP-Seq_MCF-7_Human2.05409547
22NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.05172994
23TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.04471858
24ERG_21242973_ChIP-ChIP_JURKAT_Human2.02439884
25NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.99267129
26ATF3_27146783_Chip-Seq_COLON_Human1.92891249
27STAT6_21828071_ChIP-Seq_BEAS2B_Human1.91407807
28HIF1A_21447827_ChIP-Seq_MCF-7_Human1.87004865
29NANOG_18555785_ChIP-Seq_MESCs_Mouse1.86072683
30EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.86060428
31RACK7_27058665_Chip-Seq_MCF-7_Human1.81143521
32CLOCK_20551151_ChIP-Seq_293T_Human1.80798438
33TCF3_18692474_ChIP-Seq_MEFs_Mouse1.80361458
34ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.78299557
35CTCF_27219007_Chip-Seq_Bcells_Human1.78246215
36P63_26484246_Chip-Seq_KERATINOCYTES_Human1.73110634
37ELK3_25401928_ChIP-Seq_HUVEC_Human1.69650154
38ZFP281_18757296_ChIP-ChIP_E14_Mouse1.67517469
39SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.65803845
40EGR1_19374776_ChIP-ChIP_THP-1_Human1.65208455
41* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.65132122
42* TET1_21451524_ChIP-Seq_MESCs_Mouse1.64193408
43SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.64172068
44SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.59845133
45ESR1_21235772_ChIP-Seq_MCF-7_Human1.59025518
46E2F7_22180533_ChIP-Seq_HELA_Human1.58453166
47SMC4_20622854_ChIP-Seq_HELA_Human1.55873715
48* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.52563967
49NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.51907412
50* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.51432836
51ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.51364061
52MYC_22102868_ChIP-Seq_BL_Human1.49532407
53PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.48655885
54AR_21909140_ChIP-Seq_LNCAP_Human1.48278478
55KLF4_18555785_ChIP-Seq_MESCs_Mouse1.47743265
56RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.46127751
57TRIM28_21343339_ChIP-Seq_HEK293_Human1.45790213
58EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.42889559
59TCF3_18692474_ChIP-Seq_MESCs_Mouse1.41882493
60TP63_22573176_ChIP-Seq_HFKS_Human1.40960345
61* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.40132979
62TET1_21490601_ChIP-Seq_MESCs_Mouse1.39020610
63ESR1_20079471_ChIP-ChIP_T-47D_Human1.38034931
64* EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.37228073
65WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.36604857
66EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.36021782
67OCT4_18692474_ChIP-Seq_MEFs_Mouse1.34030444
68MYC_19030024_ChIP-ChIP_MESCs_Mouse1.33614721
69DNAJC2_21179169_ChIP-ChIP_NT2_Human1.33522351
70* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.33496359
71* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.33479554
72NANOG_21062744_ChIP-ChIP_HESCs_Human1.32997341
73* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.30211736
74* TP53_23651856_ChIP-Seq_MEFs_Mouse1.30192469
75TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.29461904
76* NANOG_18692474_ChIP-Seq_MEFs_Mouse1.27861647
77ZFP281_27345836_Chip-Seq_ESCs_Mouse1.27847542
78CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.27708336
79TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.27702593
80MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.26658571
81SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.26043532
82SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.26043532
83* RUNX1_27514584_Chip-Seq_MCF-7_Human1.25481743
84TP53_20018659_ChIP-ChIP_R1E_Mouse1.25451830
85EZH2_27294783_Chip-Seq_ESCs_Mouse1.25320273
86NELFA_20434984_ChIP-Seq_ESCs_Mouse1.25059015
87SA1_27219007_Chip-Seq_ERYTHROID_Human1.24504876
88* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.24494117
89MYC_18358816_ChIP-ChIP_MESCs_Mouse1.24082808
90CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.23145876
91TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.22865318
92JARID2_20075857_ChIP-Seq_MESCs_Mouse1.22509872
93SOX9_24532713_ChIP-Seq_HFSC_Mouse1.22372561
94* SOX2_18692474_ChIP-Seq_MEFs_Mouse1.22327157
95CTCF_27219007_Chip-Seq_ERYTHROID_Human1.22004238
96CDX2_20551321_ChIP-Seq_CACO-2_Human1.21934113
97TP53_22127205_ChIP-Seq_IMR90_Human1.20589743
98KLF5_25053715_ChIP-Seq_YYC3_Human1.20099136
99NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.20056738
100SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.19675092
101KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.19475352
102POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.19329665
103SMC3_22415368_ChIP-Seq_MEFs_Mouse1.18852000
104MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.18794687
105UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.18585053
106EZH2_18974828_ChIP-Seq_MESCs_Mouse1.18415077
107RNF2_18974828_ChIP-Seq_MESCs_Mouse1.18415077
108MTF2_20144788_ChIP-Seq_MESCs_Mouse1.18208679
109KDM2B_26808549_Chip-Seq_DND41_Human1.18090125
110* NANOG_18692474_ChIP-Seq_MESCs_Mouse1.17696805
111MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.17545883
112ESR1_15608294_ChIP-ChIP_MCF-7_Human1.16927075
113TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.16841379
114KDM2B_26808549_Chip-Seq_K562_Human1.16075806
115PPAR_26484153_Chip-Seq_NCI-H1993_Human1.13395871
116SRY_22984422_ChIP-ChIP_TESTIS_Rat1.13196149
117KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.12606971
118SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.10872668
119UBF1/2_26484160_Chip-Seq_HMECs_Human1.10778318
120* STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.10710992
121* SOX2_18692474_ChIP-Seq_MESCs_Mouse1.10423243
122CREB1_26743006_Chip-Seq_LNCaP_Human1.09792971
123* LXR_22292898_ChIP-Seq_THP-1_Human1.09754650
124SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.09207885
125SUZ12_27294783_Chip-Seq_ESCs_Mouse1.09094418
126FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.08930400
127* POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.08175726
128TBX20_22080862_ChIP-Seq_HEART_Mouse1.07868295
129TBX20_22328084_ChIP-Seq_HEART_Mouse1.07868295
130CHD1_26751641_Chip-Seq_LNCaP_Human1.07322336
131SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.06813968
132NCOR1_26117541_ChIP-Seq_K562_Human1.06599047
133* PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.06402905
134POU5F1_16518401_ChIP-PET_MESCs_Mouse1.05727708
135RNF2_27304074_Chip-Seq_ESCs_Mouse1.05725961
136CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.05197942
137P68_20966046_ChIP-Seq_HELA_Human1.04397133
138PPARA_22158963_ChIP-Seq_LIVER_Mouse1.04352660
139EED_16625203_ChIP-ChIP_MESCs_Mouse1.03811119
140ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.03158090
141SMC1_22415368_ChIP-Seq_MEFs_Mouse1.02661882
142SALL1_21062744_ChIP-ChIP_HESCs_Human1.02159625
143TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.01971410
144HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.01674325
145ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.01629807
146GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.01461013
147XRN2_22483619_ChIP-Seq_HELA_Human1.01150826
148RARB_24833708_ChIP-Seq_LIVER_Mouse1.00829925
149ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.00790672
150ETS1_20019798_ChIP-Seq_JURKAT_Human1.00771729
151RARA_24833708_ChIP-Seq_LIVER_Mouse1.00385171
152E2F1_20622854_ChIP-Seq_HELA_Human0.98317265
153* SOX2_27498859_Chip-Seq_STOMACH_Mouse0.98059003
154JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.97150205
155SOX2_20726797_ChIP-Seq_SW620_Human0.96212027
156SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.96004255

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog3.35896227
2MP0004084_abnormal_cardiac_muscle3.12125184
3MP0000579_abnormal_nail_morphology3.04192681
4MP0000750_abnormal_muscle_regeneration2.62314189
5MP0009780_abnormal_chondrocyte_physiolo2.57082764
6MP0005623_abnormal_meninges_morphology2.56307044
7MP0010352_gastrointestinal_tract_polyps2.39647649
8MP0000751_myopathy2.38438785
9MP0005670_abnormal_white_adipose2.27264363
10MP0003566_abnormal_cell_adhesion2.20766409
11MP0005330_cardiomyopathy2.14777182
12MP0000467_abnormal_esophagus_morphology2.05348760
13MP0002653_abnormal_ependyma_morphology2.01254816
14MP0008438_abnormal_cutaneous_collagen2.00134234
15MP0000566_synostosis1.98914410
16MP0004957_abnormal_blastocyst_morpholog1.98555583
17MP0005275_abnormal_skin_tensile1.98319846
18MP0004233_abnormal_muscle_weight1.95135927
19MP0010030_abnormal_orbit_morphology1.95123339
20MP0002269_muscular_atrophy1.86513413
21MP0000013_abnormal_adipose_tissue1.86117788
22MP0010234_abnormal_vibrissa_follicle1.85640874
23MP0003950_abnormal_plasma_membrane1.83660136
24MP0004087_abnormal_muscle_fiber1.81740121
25MP0000537_abnormal_urethra_morphology1.76500441
26MP0003941_abnormal_skin_development1.73174552
27MP0002249_abnormal_larynx_morphology1.70143155
28MP0000749_muscle_degeneration1.69487804
29MP0004215_abnormal_myocardial_fiber1.68327760
30MP0004036_abnormal_muscle_relaxation1.68187631
31MP0003111_abnormal_nucleus_morphology1.68014889
32MP0003693_abnormal_embryo_hatching1.67850142
33MP0000733_abnormal_muscle_development1.65524536
34MP0004272_abnormal_basement_membrane1.62547718
35MP0010630_abnormal_cardiac_muscle1.57268073
36MP0005076_abnormal_cell_differentiation1.57253376
37MP0005503_abnormal_tendon_morphology1.53746340
38MP0005380_embryogenesis_phenotype1.53134856
39MP0001672_abnormal_embryogenesis/_devel1.53134856
40MP0001348_abnormal_lacrimal_gland1.51443137
41MP0003984_embryonic_growth_retardation1.50488897
42MP0000747_muscle_weakness1.49054440
43MP0002088_abnormal_embryonic_growth/wei1.48954405
44MP0005409_darkened_coat_color1.48456394
45MP0002127_abnormal_cardiovascular_syste1.42831600
46MP0002837_dystrophic_cardiac_calcinosis1.42162421
47MP0005023_abnormal_wound_healing1.41595705
48MP0001730_embryonic_growth_arrest1.40266618
49MP0004264_abnormal_extraembryonic_tissu1.38545721
50MP0006138_congestive_heart_failure1.36572642
51MP0003045_fibrosis1.35894136
52MP0000534_abnormal_ureter_morphology1.35232823
53MP0002877_abnormal_melanocyte_morpholog1.33779969
54MP0004130_abnormal_muscle_cell1.31366924
55MP0002086_abnormal_extraembryonic_tissu1.29074524
56MP0002084_abnormal_developmental_patter1.29053878
57MP0009384_cardiac_valve_regurgitation1.28733844
58MP0001849_ear_inflammation1.28665149
59MP0003011_delayed_dark_adaptation1.28411942
60MP0003646_muscle_fatigue1.26409485
61MP0002098_abnormal_vibrissa_morphology1.25643725
62MP0005377_hearing/vestibular/ear_phenot1.25490112
63MP0003878_abnormal_ear_physiology1.25490112
64MP0002085_abnormal_embryonic_tissue1.25232520
65MP0003123_paternal_imprinting1.24677499
66MP0002796_impaired_skin_barrier1.24360474
67MP0008775_abnormal_heart_ventricle1.24059715
68MP0000759_abnormal_skeletal_muscle1.23836582
69MP0004858_abnormal_nervous_system1.22943362
70MP0000350_abnormal_cell_proliferation1.20702671
71MP0003828_pulmonary_edema1.20232138
72MP0000678_abnormal_parathyroid_gland1.19747833
73MP0002896_abnormal_bone_mineralization1.19520791
74MP0003279_aneurysm1.17065765
75MP0002972_abnormal_cardiac_muscle1.17006662
76MP0002106_abnormal_muscle_physiology1.16610634
77MP0002234_abnormal_pharynx_morphology1.15404277
78MP0003567_abnormal_fetal_cardiomyocyte1.15346192
79MP0001697_abnormal_embryo_size1.15173399
80MP0010771_integument_phenotype1.13870041
81MP0003077_abnormal_cell_cycle1.13766860
82MP0006072_abnormal_retinal_apoptosis1.13620168
83MP0004197_abnormal_fetal_growth/weight/1.13569910
84MP0005620_abnormal_muscle_contractility1.13554728
85MP0000516_abnormal_urinary_system1.12839386
86MP0005367_renal/urinary_system_phenotyp1.12839386
87MP0002080_prenatal_lethality1.12571761
88MP0003137_abnormal_impulse_conducting1.11372613
89MP0001664_abnormal_digestion1.09502762
90MP0001544_abnormal_cardiovascular_syste1.06880355
91MP0005385_cardiovascular_system_phenoty1.06880355
92MP0005501_abnormal_skin_physiology1.06193664
93MP0001502_abnormal_circadian_rhythm1.06124611
94MP0009053_abnormal_anal_canal1.04936301
95MP0004185_abnormal_adipocyte_glucose1.04685268
96MP0005451_abnormal_body_composition1.04356342
97MP0001661_extended_life_span1.04056619
98MP0002332_abnormal_exercise_endurance1.04044035
99MP0003119_abnormal_digestive_system1.03320317
100MP0005551_abnormal_eye_electrophysiolog1.03139190
101MP0002060_abnormal_skin_morphology1.01241020
102MP0003221_abnormal_cardiomyocyte_apopto1.01206827
103MP0002089_abnormal_postnatal_growth/wei1.00137803
104MP0005369_muscle_phenotype0.99817440
105MP0001958_emphysema0.99193940
106MP0000003_abnormal_adipose_tissue0.99146755
107MP0004145_abnormal_muscle_electrophysio0.98440391
108MP0003942_abnormal_urinary_system0.98207177
109MP0000762_abnormal_tongue_morphology0.97510369
110MP0005083_abnormal_biliary_tract0.97296520
111MP0002090_abnormal_vision0.96803133
112MP0004484_altered_response_of0.96401845
113MP0009250_abnormal_appendicular_skeleto0.96377868
114MP0005257_abnormal_intraocular_pressure0.96083223
115MP0003091_abnormal_cell_migration0.95991848
116MP0003283_abnormal_digestive_organ0.95502862
117MP0001216_abnormal_epidermal_layer0.94489631
118MP0000428_abnormal_craniofacial_morphol0.92513440
119MP0010307_abnormal_tumor_latency0.92367887
120MP0000462_abnormal_digestive_system0.92039921
121MP0002925_abnormal_cardiovascular_devel0.91966293
122MP0003879_abnormal_hair_cell0.91803840
123MP0005666_abnormal_adipose_tissue0.90764414
124MP0000266_abnormal_heart_morphology0.89771204
125MP0003329_amyloid_beta_deposits0.89237212
126MP0005595_abnormal_vascular_smooth0.89130151
127MP0003453_abnormal_keratinocyte_physiol0.88932608
128MP0005423_abnormal_somatic_nervous0.88668755
129MP0000538_abnormal_urinary_bladder0.87327506
130MP0005375_adipose_tissue_phenotype0.87265032
131MP0001299_abnormal_eye_distance/0.86059488
132MP0004043_abnormal_pH_regulation0.85035713
133MP0008932_abnormal_embryonic_tissue0.84340209
134MP0010678_abnormal_skin_adnexa0.82951379
135MP0002932_abnormal_joint_morphology0.82850491
136MP0002108_abnormal_muscle_morphology0.82418744
137MP0005508_abnormal_skeleton_morphology0.82089673
138MP0005171_absent_coat_pigmentation0.79078237
139MP0003115_abnormal_respiratory_system0.78541371
140MP0000163_abnormal_cartilage_morphology0.75951835
141MP0000049_abnormal_middle_ear0.72419344
142MP0003755_abnormal_palate_morphology0.72068815
143MP0000377_abnormal_hair_follicle0.69802670
144MP0010368_abnormal_lymphatic_system0.69747007
145MP0003385_abnormal_body_wall0.68484251

Predicted human phenotypes

RankGene SetZ-score
1Muscle fiber splitting (HP:0003555)4.21948673
2Premature rupture of membranes (HP:0001788)4.11859369
3Difficulty climbing stairs (HP:0003551)4.09062760
4Right ventricular cardiomyopathy (HP:0011663)3.92180311
5Increased connective tissue (HP:0009025)3.91344573
6Muscle fiber inclusion bodies (HP:0100299)3.55471551
7Ankle contracture (HP:0006466)3.51456514
8Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.48830502
9Nemaline bodies (HP:0003798)3.41022007
10Protrusio acetabuli (HP:0003179)3.40086267
11Sudden death (HP:0001699)3.05444964
12Ventricular tachycardia (HP:0004756)3.04029607
13Hyperacusis (HP:0010780)3.02643020
14Round ear (HP:0100830)2.93300415
15Hyporeflexia of lower limbs (HP:0002600)2.87525828
16Cerebral aneurysm (HP:0004944)2.83412865
17Shallow orbits (HP:0000586)2.76797150
18Distal upper limb amyotrophy (HP:0007149)2.75483120
19Upper limb amyotrophy (HP:0009129)2.75483120
20Difficulty running (HP:0009046)2.74797148
21Atrophic scars (HP:0001075)2.69453258
22Congenital stationary night blindness (HP:0007642)2.68984622
23Testicular atrophy (HP:0000029)2.63032269
24Shawl scrotum (HP:0000049)2.59123543
25Bundle branch block (HP:0011710)2.57689764
26Ventricular fibrillation (HP:0001663)2.53799023
27Short humerus (HP:0005792)2.51256637
28Aplasia/hypoplasia of the humerus (HP:0006507)2.48103690
29Hand muscle atrophy (HP:0009130)2.45355087
30Mildly elevated creatine phosphokinase (HP:0008180)2.44435210
31Exercise-induced muscle cramps (HP:0003710)2.43257195
32Selective tooth agenesis (HP:0001592)2.40942384
33Type 1 muscle fiber predominance (HP:0003803)2.38432730
34Multiple enchondromatosis (HP:0005701)2.38239697
35Trismus (HP:0000211)2.37644474
36Lower limb amyotrophy (HP:0007210)2.36864514
37Short nail (HP:0001799)2.36549736
38Coronal craniosynostosis (HP:0004440)2.35598700
39Broad face (HP:0000283)2.33791862
40Atrioventricular block (HP:0001678)2.33063770
41Ulnar deviation of the wrist (HP:0003049)2.32690346
42Bladder diverticulum (HP:0000015)2.31761004
43Breast hypoplasia (HP:0003187)2.30827498
44Bony spicule pigmentary retinopathy (HP:0007737)2.30483961
45Abnormality of the lower motor neuron (HP:0002366)2.30003680
46Vascular tortuosity (HP:0004948)2.27446589
47Alopecia of scalp (HP:0002293)2.27326133
48Abnormality of the distal phalanges of the toes (HP:0010182)2.25818742
49Abnormality of the umbilical cord (HP:0010881)2.22997931
50Scotoma (HP:0000575)2.22145257
51Ependymoma (HP:0002888)2.21058832
52Fused cervical vertebrae (HP:0002949)2.20204312
53Neck muscle weakness (HP:0000467)2.20074795
54Milia (HP:0001056)2.18724604
55Arterial tortuosity (HP:0005116)2.18454759
56Achilles tendon contracture (HP:0001771)2.16017014
57Stridor (HP:0010307)2.15679001
58Ventricular arrhythmia (HP:0004308)2.12811675
59Wrist flexion contracture (HP:0001239)2.10790201
60Astrocytoma (HP:0009592)2.10698416
61Abnormality of the astrocytes (HP:0100707)2.10698416
62Syncope (HP:0001279)2.09806289
63Ulnar bowing (HP:0003031)2.09238854
64Progressive muscle weakness (HP:0003323)2.06926658
65Cervical subluxation (HP:0003308)2.06542222
66Neonatal short-limb short stature (HP:0008921)2.04957915
67Abnormality of the calf musculature (HP:0001430)2.04518677
68Distal lower limb muscle weakness (HP:0009053)2.03161195
69Centrally nucleated skeletal muscle fibers (HP:0003687)2.01912584
70Turricephaly (HP:0000262)2.00762663
71Hip contracture (HP:0003273)1.99062605
72Areflexia of lower limbs (HP:0002522)1.97617615
73Broad metatarsal (HP:0001783)1.95126675
74Generalized amyotrophy (HP:0003700)1.95006817
75Abnormal atrioventricular conduction (HP:0005150)1.94864509
76Increased variability in muscle fiber diameter (HP:0003557)1.94718347
77Myopathic facies (HP:0002058)1.94037196
78Spinal rigidity (HP:0003306)1.93308528
79Central scotoma (HP:0000603)1.93076423
80Rectal prolapse (HP:0002035)1.92171705
81Spinal muscular atrophy (HP:0007269)1.90907016
82Aneurysm (HP:0002617)1.89130597
83Asymmetric septal hypertrophy (HP:0001670)1.89093471
84Insomnia (HP:0100785)1.88779970
85Bulbar palsy (HP:0001283)1.88214070
86Atrial fibrillation (HP:0005110)1.87986844
87Fragile skin (HP:0001030)1.86187834
88Aplasia of the phalanges of the hand (HP:0009802)1.85898370
89Aplasia involving bones of the extremities (HP:0009825)1.85898370
90Aplasia involving bones of the upper limbs (HP:0009823)1.85898370
91Flat acetabular roof (HP:0003180)1.85857361
92Advanced eruption of teeth (HP:0006288)1.85029438
93Pterygium (HP:0001059)1.84191747
94Aortic aneurysm (HP:0004942)1.84060073
95Hyperkalemia (HP:0002153)1.83547287
96EMG: myopathic abnormalities (HP:0003458)1.82832542
97Mitral regurgitation (HP:0001653)1.81859872
98Vertebral compression fractures (HP:0002953)1.81387341
99Gout (HP:0001997)1.81243467
100Primary atrial arrhythmia (HP:0001692)1.80973622
101Supraventricular arrhythmia (HP:0005115)1.80414861
102Distal lower limb amyotrophy (HP:0008944)1.80284561
103Genu recurvatum (HP:0002816)1.80104266
104Scapular winging (HP:0003691)1.79610638
105Acanthosis nigricans (HP:0000956)1.79257510
106Fatigable weakness (HP:0003473)1.79079525
107Abnormality of the neuromuscular junction (HP:0003398)1.79079525
108Muscle fibrillation (HP:0010546)1.78869160
109Abnormality of the Achilles tendon (HP:0005109)1.78046183
110Distal arthrogryposis (HP:0005684)1.77507822
111Elbow flexion contracture (HP:0002987)1.77195993
112Abnormality of the calcaneus (HP:0008364)1.77099230
113Posterior subcapsular cataract (HP:0007787)1.75074119
114Heart block (HP:0012722)1.74843989
115Supraventricular tachycardia (HP:0004755)1.74691869
116Abnormality of the labia minora (HP:0012880)1.74222956
117Spinal cord compression (HP:0002176)1.73930521
118Nail dystrophy (HP:0008404)1.73732564
119Chorioretinal atrophy (HP:0000533)1.73490993
120Ridged nail (HP:0001807)1.73212795
121Bronchomalacia (HP:0002780)1.72827506
122Fragile nails (HP:0001808)1.71879699
123Easy fatigability (HP:0003388)1.71186890
124Abnormality of skeletal muscle fiber size (HP:0012084)1.71086033
125Ureteral duplication (HP:0000073)1.70942645
126Dilatation of the ascending aorta (HP:0005111)1.70534072
127EMG: neuropathic changes (HP:0003445)1.70162251
128Natal tooth (HP:0000695)1.69899826
129Lipoatrophy (HP:0100578)1.69526002
130Plantar hyperkeratosis (HP:0007556)1.69233121
131Aortic dissection (HP:0002647)1.67911036
132Myoglobinuria (HP:0002913)1.67516444
133Pendular nystagmus (HP:0012043)1.66257007
134Reduced subcutaneous adipose tissue (HP:0003758)1.65557540
135Glioma (HP:0009733)1.65062383
136Abnormality of the aortic arch (HP:0012303)1.64279008
137Dysmetric saccades (HP:0000641)1.64265405
138Exercise-induced myalgia (HP:0003738)1.63392969
139Obstructive sleep apnea (HP:0002870)1.63359854
140Radial bowing (HP:0002986)1.63237920
141Wormian bones (HP:0002645)1.62436344
142Thin bony cortex (HP:0002753)1.62055994
143Elfin facies (HP:0004428)1.61351079
144Bowing of the arm (HP:0006488)1.60907493
145Bowed forearm bones (HP:0003956)1.60907493
146Myotonia (HP:0002486)1.60356005
147Limited hip movement (HP:0008800)1.60168567
148Overriding aorta (HP:0002623)1.60145821
149Hypoplastic nipples (HP:0002557)1.59641283

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST1R5.66715436
2EPHA25.29038057
3AKT33.38812895
4TRIB33.24180217
5TTN3.18813998
6NEK12.81423236
7IRAK32.17887187
8EEF2K2.14551961
9DDR22.12665016
10LATS22.07324951
11CDK122.00949640
12PDK31.99522603
13PDK41.99522603
14PKN21.96754415
15RIPK11.93764628
16NEK21.93582301
17PDK21.85198803
18BUB11.76102633
19WEE11.74270600
20LATS11.63540175
21TESK11.60359721
22MUSK1.59638015
23TTK1.55900799
24STK38L1.50614077
25RPS6KB21.50436295
26PAK41.43105495
27PDGFRA1.41687349
28FER1.40420638
29MAPKAPK31.38967446
30TSSK61.37728535
31ERN11.31864240
32PIM21.29733245
33STK381.24390069
34LIMK11.21974958
35WNK41.18213361
36MAP3K101.17579640
37ALK1.17512121
38MTOR1.17506494
39LMTK21.17194871
40DMPK1.14837296
41PTK21.13912015
42PAK21.10606664
43MYLK1.10229539
44ICK1.08736066
45LRRK21.07414591
46MAP3K91.04430211
47PRKD21.04109586
48CAMK2G1.01391186
49TYRO30.99919436
50EPHB10.99633326
51PRKG20.99458399
52PRKCI0.98903126
53BMX0.98180981
54GRK10.93151818
55SMG10.92685943
56MAP3K30.92058126
57PLK10.90083602
58STK30.89504063
59RPS6KA40.89200416
60STK100.85556102
61CAMK2D0.85128221
62BRSK20.84690366
63CAMK2B0.84218964
64NME20.84159640
65PAK30.84157648
66PTK60.84080763
67GRK50.81799611
68ILK0.80383445
69PDPK10.78342044
70PNCK0.78016755
71PHKG20.76330114
72PHKG10.76330114
73AKT20.74635654
74CDK80.72432306
75EPHA40.69775227
76CDK70.68878622
77ABL20.68781578
78RPS6KA20.68386948
79AURKB0.67265868
80PAK10.66947982
81MET0.66732587
82CDC42BPA0.66623316
83PINK10.66227040
84TAOK10.65521268
85MAP3K80.65273101
86NTRK10.62305699
87NME10.61218520
88PLK30.60639727
89CDK60.60627120
90PIK3CA0.60047118
91ZAK0.58874197
92MAP2K60.58637404
93PAK60.57912901
94SIK10.57092733
95BRSK10.56853172
96ERBB40.56386712
97IRAK20.55490010
98STK390.54983118
99CHEK20.54953211
100AURKA0.54261101
101MOS0.53731476
102DYRK1B0.53304835
103PLK40.53180389
104DAPK30.52824450
105MAP3K70.52465279
106CDK40.51776171
107PRKAA10.51377017
108MAP2K20.51116403
109MAP2K10.50381094
110FGFR10.50091243
111PRKD30.49276325
112ADRBK10.48945061
113MARK10.48508578
114PTK2B0.47958724
115CSNK1E0.46626765
116MAPK150.45271394
117MAPK110.44230843
118DAPK20.43466672
119CHEK10.40018825
120EPHB20.39807322
121SCYL20.39624542
122PDGFRB0.38760069
123MAP2K30.37438620
124PRKD10.36888374
125MATK0.36887505
126MAPK120.36546137
127WNK10.36133328
128CAMKK10.35205664
129TRPM70.34460577
130PIM10.33424025
131MARK20.33096531
132NEK60.32508531
133ARAF0.32030968
134CDK20.31985335
135OBSCN0.29947720
136ROCK10.29387065
137ROCK20.28759388
138RPS6KC10.28038458
139RPS6KL10.28038458
140CAMK10.28035742
141RPS6KA60.27575297
142PRPF4B0.25411447
143BRAF0.24278199
144PKN10.24169029
145CDK90.24102743
146MAPKAPK50.23210470
147PRKAA20.22718624

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047443.49745866
2Vitamin B6 metabolism_Homo sapiens_hsa007503.26376823
32-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.40998251
4Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.34586020
5Dilated cardiomyopathy_Homo sapiens_hsa054142.31851385
6Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.28192720
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.28059864
8Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.11264798
9RNA transport_Homo sapiens_hsa030132.02192799
10Hippo signaling pathway_Homo sapiens_hsa043902.01963985
11Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.92170282
12ECM-receptor interaction_Homo sapiens_hsa045121.89954386
13Tight junction_Homo sapiens_hsa045301.87618941
14mTOR signaling pathway_Homo sapiens_hsa041501.78759071
15Small cell lung cancer_Homo sapiens_hsa052221.73036101
16Nitrogen metabolism_Homo sapiens_hsa009101.68760920
17Focal adhesion_Homo sapiens_hsa045101.67445184
18Bladder cancer_Homo sapiens_hsa052191.66431918
19Fructose and mannose metabolism_Homo sapiens_hsa000511.63563080
20Adherens junction_Homo sapiens_hsa045201.63229721
21Arginine biosynthesis_Homo sapiens_hsa002201.57168245
22Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.55184655
23p53 signaling pathway_Homo sapiens_hsa041151.54913454
24Cyanoamino acid metabolism_Homo sapiens_hsa004601.52765061
25Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.51517233
26Proteoglycans in cancer_Homo sapiens_hsa052051.50136714
27Sulfur metabolism_Homo sapiens_hsa009201.47999514
28Cell cycle_Homo sapiens_hsa041101.38070129
29Hedgehog signaling pathway_Homo sapiens_hsa043401.37794289
30Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.34692215
31Biosynthesis of amino acids_Homo sapiens_hsa012301.33883743
32Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.30858957
33Arginine and proline metabolism_Homo sapiens_hsa003301.26403518
34Central carbon metabolism in cancer_Homo sapiens_hsa052301.25876609
35Oocyte meiosis_Homo sapiens_hsa041141.23537992
36Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.22648557
37Bile secretion_Homo sapiens_hsa049761.21964453
38HIF-1 signaling pathway_Homo sapiens_hsa040661.20470528
39Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.19873460
40Axon guidance_Homo sapiens_hsa043601.16130368
41Basal cell carcinoma_Homo sapiens_hsa052171.15775614
42RNA polymerase_Homo sapiens_hsa030201.14485169
43Carbon metabolism_Homo sapiens_hsa012001.13742842
44Longevity regulating pathway - mammal_Homo sapiens_hsa042111.13215912
45Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.10793697
46Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.10623116
47Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.09446371
48MicroRNAs in cancer_Homo sapiens_hsa052061.08916713
49Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.08024322
50* Thyroid hormone signaling pathway_Homo sapiens_hsa049191.03385651
51Gastric acid secretion_Homo sapiens_hsa049711.03268128
52Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.01940622
53Cardiac muscle contraction_Homo sapiens_hsa042600.99354622
54Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.99325602
55Amoebiasis_Homo sapiens_hsa051460.98244613
56AMPK signaling pathway_Homo sapiens_hsa041520.96435682
57mRNA surveillance pathway_Homo sapiens_hsa030150.90838141
58Insulin secretion_Homo sapiens_hsa049110.90475339
59TGF-beta signaling pathway_Homo sapiens_hsa043500.89059937
60Regulation of actin cytoskeleton_Homo sapiens_hsa048100.88997702
61Glycosaminoglycan degradation_Homo sapiens_hsa005310.88345678
62Chronic myeloid leukemia_Homo sapiens_hsa052200.86704162
63Aldosterone synthesis and secretion_Homo sapiens_hsa049250.86645581
64Pyruvate metabolism_Homo sapiens_hsa006200.84236906
65Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.82820363
66Thyroid cancer_Homo sapiens_hsa052160.82802918
67Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.82725775
68Pathways in cancer_Homo sapiens_hsa052000.81267761
69* Calcium signaling pathway_Homo sapiens_hsa040200.78763820
70Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.78094577
71Renal cell carcinoma_Homo sapiens_hsa052110.77274805
72Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.77039677
73HTLV-I infection_Homo sapiens_hsa051660.75797324
74Glycerophospholipid metabolism_Homo sapiens_hsa005640.74890806
75Viral myocarditis_Homo sapiens_hsa054160.74805917
76Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.74558096
77Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.73801356
78Notch signaling pathway_Homo sapiens_hsa043300.73623632
79PI3K-Akt signaling pathway_Homo sapiens_hsa041510.73566498
80Glioma_Homo sapiens_hsa052140.73342338
81Regulation of autophagy_Homo sapiens_hsa041400.73203641
82Endometrial cancer_Homo sapiens_hsa052130.72611989
83Insulin signaling pathway_Homo sapiens_hsa049100.71642254
84Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.70644989
85Estrogen signaling pathway_Homo sapiens_hsa049150.69644335
86Ovarian steroidogenesis_Homo sapiens_hsa049130.69031345
87Thyroid hormone synthesis_Homo sapiens_hsa049180.68954210
88Circadian rhythm_Homo sapiens_hsa047100.68812921
89Spliceosome_Homo sapiens_hsa030400.68659837
90Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.68367693
91Leukocyte transendothelial migration_Homo sapiens_hsa046700.68344349
92Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.68308907
93Circadian entrainment_Homo sapiens_hsa047130.66811330
94Salivary secretion_Homo sapiens_hsa049700.66535657
95Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.66061512
96VEGF signaling pathway_Homo sapiens_hsa043700.65973067
97Melanoma_Homo sapiens_hsa052180.65291633
98Galactose metabolism_Homo sapiens_hsa000520.65054781
99Phenylalanine metabolism_Homo sapiens_hsa003600.65048387
100Viral carcinogenesis_Homo sapiens_hsa052030.64699836
101Oxytocin signaling pathway_Homo sapiens_hsa049210.64051405
102Insulin resistance_Homo sapiens_hsa049310.63081900
103cGMP-PKG signaling pathway_Homo sapiens_hsa040220.61192762
104Histidine metabolism_Homo sapiens_hsa003400.61069103
105Pentose phosphate pathway_Homo sapiens_hsa000300.60771912
106PPAR signaling pathway_Homo sapiens_hsa033200.60642258
107Adipocytokine signaling pathway_Homo sapiens_hsa049200.59916483
108Wnt signaling pathway_Homo sapiens_hsa043100.59825910
109Lysine degradation_Homo sapiens_hsa003100.59507280
110Endocytosis_Homo sapiens_hsa041440.59064862
111Protein digestion and absorption_Homo sapiens_hsa049740.58493382
112Pancreatic secretion_Homo sapiens_hsa049720.57431302
113GnRH signaling pathway_Homo sapiens_hsa049120.57049234
114ErbB signaling pathway_Homo sapiens_hsa040120.57035777
115Synaptic vesicle cycle_Homo sapiens_hsa047210.56817333
116Rap1 signaling pathway_Homo sapiens_hsa040150.56764940
117Nucleotide excision repair_Homo sapiens_hsa034200.56282548
118Fatty acid biosynthesis_Homo sapiens_hsa000610.55020980
119Sphingolipid metabolism_Homo sapiens_hsa006000.53676337
120Glucagon signaling pathway_Homo sapiens_hsa049220.53408961
121Vibrio cholerae infection_Homo sapiens_hsa051100.53256877
122Glutamatergic synapse_Homo sapiens_hsa047240.52563730
123Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.52095930
124Prostate cancer_Homo sapiens_hsa052150.52063373
125Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.52038457
126Sulfur relay system_Homo sapiens_hsa041220.51698907
127Renin secretion_Homo sapiens_hsa049240.51159836
128* AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.49591938
129FoxO signaling pathway_Homo sapiens_hsa040680.48278889
130Phospholipase D signaling pathway_Homo sapiens_hsa040720.48039678
131Melanogenesis_Homo sapiens_hsa049160.47971397
132Base excision repair_Homo sapiens_hsa034100.47715500
133cAMP signaling pathway_Homo sapiens_hsa040240.47348028
134Gap junction_Homo sapiens_hsa045400.46941631
135Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.45496971
136Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.45139913
137Vascular smooth muscle contraction_Homo sapiens_hsa042700.44811332
138Non-small cell lung cancer_Homo sapiens_hsa052230.42882152
139Epstein-Barr virus infection_Homo sapiens_hsa051690.41155235
140Mineral absorption_Homo sapiens_hsa049780.40618166
141* Inositol phosphate metabolism_Homo sapiens_hsa005620.40021489

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