PLCG2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a transmembrane signaling enzyme that catalyzes the conversion of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate to 1D-myo-inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG) using calcium as a cofactor. IP3 and DAG are second messenger molecules important for transmitting signals from growth factor receptors and immune system receptors across the cell membrane. Mutations in this gene have been found in autoinflammation, antibody deficiency, and immune dysregulation syndrome and familial cold autoinflammatory syndrome 3. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)7.87200882
2nuclear pore organization (GO:0006999)6.78376369
3pore complex assembly (GO:0046931)5.86033321
4antigen processing and presentation of endogenous antigen (GO:0019883)5.18609177
5antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.99570774
6antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.99570774
7positive regulation of gamma-delta T cell activation (GO:0046645)4.94949298
8cellular response to ethanol (GO:0071361)4.92152800
9negative regulation of DNA repair (GO:0045738)4.89051295
10positive regulation of B cell differentiation (GO:0045579)4.87282033
11phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)4.85268621
12innate immune response in mucosa (GO:0002227)4.67084835
13antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.66825033
14interkinetic nuclear migration (GO:0022027)4.53957860
15regulation of B cell receptor signaling pathway (GO:0050855)4.43663374
16dosage compensation (GO:0007549)4.41999599
17* B cell receptor signaling pathway (GO:0050853)4.26543194
18cytoplasmic mRNA processing body assembly (GO:0033962)4.25911699
19regulation of B cell differentiation (GO:0045577)4.25867700
20monoubiquitinated protein deubiquitination (GO:0035520)4.24041812
21immunoglobulin mediated immune response (GO:0016064)4.16370632
22lipid translocation (GO:0034204)4.15700499
23phospholipid translocation (GO:0045332)4.15700499
24histone H3-K36 demethylation (GO:0070544)4.11600765
25embryonic process involved in female pregnancy (GO:0060136)3.95514371
26ribosomal small subunit assembly (GO:0000028)3.87149700
27mucosal immune response (GO:0002385)3.79618540
28regulation of interferon-beta biosynthetic process (GO:0045357)3.79069169
29modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.78123079
30positive regulation by organism of defense response of other organism involved in symbiotic interact3.78123079
31modulation by symbiont of host immune response (GO:0052553)3.78123079
32positive regulation by symbiont of host defense response (GO:0052509)3.78123079
33modulation by symbiont of host defense response (GO:0052031)3.78123079
34modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.78123079
35regulation of pigment cell differentiation (GO:0050932)3.72476310
36protein K48-linked deubiquitination (GO:0071108)3.64817502
37regulation of gamma-delta T cell differentiation (GO:0045586)3.62680107
38positive regulation of transcription from RNA polymerase III promoter (GO:0045945)3.61504970
39antibacterial humoral response (GO:0019731)3.59253115
40organ or tissue specific immune response (GO:0002251)3.58109929
41hepatocyte apoptotic process (GO:0097284)3.57928121
42B cell mediated immunity (GO:0019724)3.55709429
43peptidyl-lysine dimethylation (GO:0018027)3.50770362
44regulation of gamma-delta T cell activation (GO:0046643)3.48789781
45antigen processing and presentation via MHC class Ib (GO:0002475)3.48769432
46histone H3-K9 demethylation (GO:0033169)3.47725575
47neutrophil activation involved in immune response (GO:0002283)3.46141817
48Arp2/3 complex-mediated actin nucleation (GO:0034314)3.44598945
49negative regulation of phagocytosis (GO:0050765)3.44418528
50nucleus localization (GO:0051647)3.42953187
51respiratory burst (GO:0045730)3.40611926
52pre-miRNA processing (GO:0031054)3.39129669
53histone lysine demethylation (GO:0070076)3.35865111
54labyrinthine layer development (GO:0060711)3.34588714
55positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.28297509
56positive regulation of developmental pigmentation (GO:0048087)3.25455968
57antimicrobial humoral response (GO:0019730)3.22848273
58defense response to protozoan (GO:0042832)3.22291783
59positive regulation of interferon-alpha production (GO:0032727)3.20550008
60histone demethylation (GO:0016577)3.18290689
61embryonic camera-type eye morphogenesis (GO:0048596)3.17532052
62regulation of RNA export from nucleus (GO:0046831)3.17032488
63cellular response to zinc ion (GO:0071294)3.16281755
64regulation of protein polyubiquitination (GO:1902914)3.15993433
65regulation of establishment of cell polarity (GO:2000114)3.14542000
66viral transcription (GO:0019083)3.11836163
67insulin-like growth factor receptor signaling pathway (GO:0048009)3.11726334
68protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)3.10079283
69response to peptidoglycan (GO:0032494)3.09061535
70iron ion import (GO:0097286)3.06924987
71establishment of nucleus localization (GO:0040023)3.06873005
72macrophage activation involved in immune response (GO:0002281)3.05775113
73positive regulation of DNA-templated transcription, initiation (GO:2000144)3.05400363
74regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.05108896
75negative regulation of myotube differentiation (GO:0010832)3.05025284
76response to protozoan (GO:0001562)3.05022420
77regulation of interferon-alpha production (GO:0032647)3.03081709
78neutrophil activation (GO:0042119)3.01724466
79histone mRNA catabolic process (GO:0071044)2.99482167
80negative regulation of fatty acid transport (GO:2000192)2.97193875
81response to muramyl dipeptide (GO:0032495)2.97189057
82negative regulation of B cell proliferation (GO:0030889)2.96894634
83cellular extravasation (GO:0045123)2.96709466
84translational termination (GO:0006415)2.95082176
85regulation of interleukin-12 biosynthetic process (GO:0045075)2.93879076
86peptidyl-threonine phosphorylation (GO:0018107)2.92704431
87definitive hemopoiesis (GO:0060216)2.92140206
88myeloid dendritic cell activation (GO:0001773)2.91387395
89T cell homeostasis (GO:0043029)2.91149641
90B cell homeostasis (GO:0001782)2.90544574
91mitotic sister chromatid cohesion (GO:0007064)2.89980193
92positive regulation of antigen processing and presentation (GO:0002579)2.89845052
93peptidyl-threonine modification (GO:0018210)2.89204943
94positive regulation of transcription initiation from RNA polymerase II promoter (GO:0060261)2.88923187
95histone-serine phosphorylation (GO:0035404)2.86261327
96NIK/NF-kappaB signaling (GO:0038061)2.86228782
97DNA unwinding involved in DNA replication (GO:0006268)2.86164273
98negative regulation of granulocyte differentiation (GO:0030853)2.85505205
99establishment of protein localization to Golgi (GO:0072600)2.85199334
100pinocytosis (GO:0006907)2.84875745
101leukocyte aggregation (GO:0070486)2.83514367
102Golgi to endosome transport (GO:0006895)2.83379586
103lymphocyte homeostasis (GO:0002260)2.80715678
104granulocyte activation (GO:0036230)2.79927948
105DNA duplex unwinding (GO:0032508)2.79565812
106replicative senescence (GO:0090399)2.78925981
107positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.78296726
108regulation of nucleobase-containing compound transport (GO:0032239)2.77674009
109detection of molecule of bacterial origin (GO:0032490)2.76658734
110striated muscle atrophy (GO:0014891)2.76597775
111determination of adult lifespan (GO:0008340)2.74559204
112regulation of B cell apoptotic process (GO:0002902)2.74413708
113natural killer cell differentiation (GO:0001779)2.73862575
114peptidyl-lysine trimethylation (GO:0018023)2.73689516
115positive T cell selection (GO:0043368)2.73457042
116myeloid cell activation involved in immune response (GO:0002275)2.73302303
117embryonic eye morphogenesis (GO:0048048)2.72473031
118coronary vasculature morphogenesis (GO:0060977)2.71934373
119TOR signaling (GO:0031929)2.71633272
120peptidyl-serine phosphorylation (GO:0018105)2.71214395
121germinal center formation (GO:0002467)2.69470782
122oocyte development (GO:0048599)2.68788385
123nucleus organization (GO:0006997)2.67836275
124regulation of necroptotic process (GO:0060544)2.67374699
125DNA geometric change (GO:0032392)2.67372002
126skeletal muscle adaptation (GO:0043501)2.66867184
127megakaryocyte development (GO:0035855)2.65864367
128myeloid dendritic cell differentiation (GO:0043011)2.65504767
129regulation of membrane lipid distribution (GO:0097035)2.65168688
130regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.63287479
131protein dealkylation (GO:0008214)2.62156605
132protein demethylation (GO:0006482)2.62156605
133regulation of histone H3-K9 methylation (GO:0051570)2.61685052
134interferon-gamma-mediated signaling pathway (GO:0060333)2.61003731
135translational elongation (GO:0006414)2.60750823
136natural killer cell mediated cytotoxicity (GO:0042267)2.60575779
137natural killer cell mediated immunity (GO:0002228)2.60575779
138telomere maintenance via semi-conservative replication (GO:0032201)2.60005886
139leukocyte homeostasis (GO:0001776)2.60001200
140mast cell activation (GO:0045576)2.59982864
141regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.59300678
142regulation of establishment or maintenance of cell polarity (GO:0032878)2.58932478
143DNA strand elongation involved in DNA replication (GO:0006271)2.58637489
144positive regulation of cellular response to insulin stimulus (GO:1900078)2.58473637
145response to type I interferon (GO:0034340)2.58244030
146negative regulation of interleukin-12 production (GO:0032695)2.57870792
147retrograde transport, vesicle recycling within Golgi (GO:0000301)2.57563324
148response to interferon-beta (GO:0035456)2.55935793
149cellular response to type I interferon (GO:0071357)2.55284468
150type I interferon signaling pathway (GO:0060337)2.55284468
151actin nucleation (GO:0045010)2.55123137
152macroautophagy (GO:0016236)2.54268956
153positive regulation of interferon-beta production (GO:0032728)2.54223015
154lymph node development (GO:0048535)2.53333461
155cerebellar Purkinje cell differentiation (GO:0021702)2.53317562
156negative regulation of erythrocyte differentiation (GO:0045647)2.53278920
157response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.51554456
158response to host immune response (GO:0052572)2.51554456
159centrosome duplication (GO:0051298)2.51097367
160regulation of mast cell degranulation (GO:0043304)2.50844036
161negative regulation of histone methylation (GO:0031061)2.50271794
162negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.50156933
1633-UTR-mediated mRNA stabilization (GO:0070935)2.49707026
164chromatin assembly (GO:0031497)2.48849765
165DNA strand elongation (GO:0022616)2.48054840
166JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.47556904
167nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.47373652
168cytoskeletal anchoring at plasma membrane (GO:0007016)2.47140355
169peptidyl-lysine methylation (GO:0018022)2.46884864
170positive regulation of insulin receptor signaling pathway (GO:0046628)2.46689834
171regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)2.45863846
172response to host (GO:0075136)2.45460115
173response to host defenses (GO:0052200)2.45460115
174response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.45460115
175telomere maintenance via recombination (GO:0000722)2.45027621
176negative regulation of cell killing (GO:0031342)2.44673998
177negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.44673998
178regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)2.43563631
179protein targeting to Golgi (GO:0000042)2.43490457
180Peyers patch development (GO:0048541)2.43420912
181mucosal-associated lymphoid tissue development (GO:0048537)2.43420912
182regulation of erythrocyte differentiation (GO:0045646)2.43258631
183early endosome to late endosome transport (GO:0045022)2.43246476
184histone H3-K4 trimethylation (GO:0080182)2.42782508
185tolerance induction (GO:0002507)2.42652669
186histone phosphorylation (GO:0016572)2.42605121
187peptidyl-serine modification (GO:0018209)2.42211981
188ribosomal small subunit biogenesis (GO:0042274)2.42187579
189regulation of antigen processing and presentation (GO:0002577)2.42069921
190fibroblast migration (GO:0010761)2.41705674
191regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.40501211
192regulation of transforming growth factor beta2 production (GO:0032909)2.40371706
193regulation of fatty acid beta-oxidation (GO:0031998)2.39220262
194positive regulation of keratinocyte differentiation (GO:0045618)2.38214488
195negative regulation of inclusion body assembly (GO:0090084)2.36867734

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.52872281
2BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse5.45589271
3IRF8_22096565_ChIP-ChIP_GC-B_Human4.28524892
4IRF8_21731497_ChIP-ChIP_J774_Mouse3.48913808
5EGR1_19374776_ChIP-ChIP_THP-1_Human3.46919237
6* MYC_22102868_ChIP-Seq_BL_Human3.27276896
7MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.13369671
8IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.10919244
9* SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.94132716
10* VDR_21846776_ChIP-Seq_THP-1_Human2.87449145
11* SCL_19346495_ChIP-Seq_HPC-7_Human2.84416914
12FOXM1_23109430_ChIP-Seq_U2OS_Human2.80290733
13STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.56902568
14SMAD_19615063_ChIP-ChIP_OVARY_Human2.56552342
15* IRF8_27001747_Chip-Seq_BMDM_Mouse2.50757731
16* MYB_21317192_ChIP-Seq_ERMYB_Mouse2.48116403
17SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.47915214
18CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.46488877
19SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.42522718
20EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.35076300
21ZNF217_24962896_ChIP-Seq_MCF-7_Human2.34489707
22NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.28805083
23FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.28342836
24* SPI1_23547873_ChIP-Seq_NB4_Human2.27403813
25RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.15416744
26E2F4_17652178_ChIP-ChIP_JURKAT_Human2.12211269
27ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.11494748
28VDR_24763502_ChIP-Seq_THP-1_Human2.07289038
29BP1_19119308_ChIP-ChIP_Hs578T_Human2.06095281
30NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.04864041
31NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.02668966
32MYB_26560356_Chip-Seq_TH2_Human2.01787930
33MAF_26560356_Chip-Seq_TH1_Human2.00859096
34FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse11.3093740
35BRD4_27068464_Chip-Seq_AML-cells_Mouse1.98531852
36TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.97247742
37MYB_26560356_Chip-Seq_TH1_Human1.89078816
38STAT4_19710469_ChIP-ChIP_TH1__Mouse1.88696481
39RUNX1_22412390_ChIP-Seq_EML_Mouse1.88073264
40FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.86606601
41TCF7_22412390_ChIP-Seq_EML_Mouse1.85910461
42SALL1_21062744_ChIP-ChIP_HESCs_Human1.82338296
43UTX_26944678_Chip-Seq_JUKART_Human1.77593493
44IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.76830647
45* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.75510551
46AHR_22903824_ChIP-Seq_MCF-7_Human1.74081954
47* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.73224666
48STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.73143233
49MYC_18555785_ChIP-Seq_MESCs_Mouse1.72877105
50* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.71636363
51FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.71115086
52* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.68350215
53CIITA_25753668_ChIP-Seq_RAJI_Human1.62909218
54TP53_16413492_ChIP-PET_HCT116_Human1.62720445
55SPI1_23127762_ChIP-Seq_K562_Human1.60444864
56CTNNB1_20460455_ChIP-Seq_HCT116_Human1.59467940
57CDX2_19796622_ChIP-Seq_MESCs_Mouse1.56591142
58ELF1_17652178_ChIP-ChIP_JURKAT_Human1.56205664
59AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.55263971
60ESR1_20079471_ChIP-ChIP_T-47D_Human1.53188298
61SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.52846181
62RUNX_20019798_ChIP-Seq_JUKART_Human1.51679305
63TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.51460088
64EGR1_23403033_ChIP-Seq_LIVER_Mouse1.47169328
65FOXO3_23340844_ChIP-Seq_DLD1_Human1.45551600
66MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.45254901
67POU3F2_20337985_ChIP-ChIP_501MEL_Human1.44945862
68ARNT_22903824_ChIP-Seq_MCF-7_Human1.44077650
69HOXB4_20404135_ChIP-ChIP_EML_Mouse1.42507679
70STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.39770900
71* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.39291991
72* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.38906813
73GATA1_22383799_ChIP-Seq_G1ME_Mouse1.37645633
74FOXM1_26456572_ChIP-Seq_MCF-7_Human1.35959081
75NOTCH1_21737748_ChIP-Seq_TLL_Human1.33721424
76* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.32501928
77SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.31544464
78MYC_19079543_ChIP-ChIP_MESCs_Mouse1.31239830
79KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.30453235
80GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.30433860
81ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.30427576
82E2F1_21310950_ChIP-Seq_MCF-7_Human1.30253690
83SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.29879728
84SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.29879728
85AR_21572438_ChIP-Seq_LNCaP_Human1.29661834
86VDR_23849224_ChIP-Seq_CD4+_Human1.28973096
87LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.28838365
88KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.27314528
89GATA1_22025678_ChIP-Seq_K562_Human1.27179759
90MAF_26560356_Chip-Seq_TH2_Human1.26800187
91KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.26324283
92ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.25709039
93ELK3_25401928_ChIP-Seq_HUVEC_Human1.25648981
94* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.24288187
95FOXP3_21729870_ChIP-Seq_TREG_Human1.21750937
96TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.21696560
97PU_27001747_Chip-Seq_BMDM_Mouse1.20247137
98* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.20033132
99RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.19818242
100FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.17847981
101TFEB_21752829_ChIP-Seq_HELA_Human1.16820661
102KDM2B_26808549_Chip-Seq_DND41_Human1.16145975
103MYC_19030024_ChIP-ChIP_MESCs_Mouse1.15589322
104PKCTHETA_26484144_Chip-Seq_BREAST_Human1.13995736
105PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.13412231
106FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.13271585
107MYC_18358816_ChIP-ChIP_MESCs_Mouse1.11404698
108XRN2_22483619_ChIP-Seq_HELA_Human1.11034020
109FOXA2_19822575_ChIP-Seq_HepG2_Human1.10800914
110CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.10457300
111* STAT3_23295773_ChIP-Seq_U87_Human1.10284513
112NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.08890155
113MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.08739787
114EST1_17652178_ChIP-ChIP_JURKAT_Human1.08393208
115HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.07998827
116FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.07982108
117PIAS1_25552417_ChIP-Seq_VCAP_Human1.07463890
118KDM2B_26808549_Chip-Seq_SUP-B15_Human1.07087900
119PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.07065121
120GATA3_27048872_Chip-Seq_THYMUS_Human1.06911346
121RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.06553707
122NRF2_20460467_ChIP-Seq_MEFs_Mouse1.06496446
123NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.06496446
124Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.06400563
125CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.06221307
126TP63_17297297_ChIP-ChIP_HaCaT_Human1.04802896
127VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.04224693
128* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.03267318
129BRD4_25478319_ChIP-Seq_HGPS_Human1.01749937
130PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.01708353
131PPAR_26484153_Chip-Seq_NCI-H1993_Human1.01590181
132NELFA_20434984_ChIP-Seq_ESCs_Mouse1.00194730
133* DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.97594417
134* SMAD4_21799915_ChIP-Seq_A2780_Human0.96737935
135GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.95780622
136PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.95529154
137* GATA2_19941826_ChIP-Seq_K562_Human0.95379583
138KDM5A_27292631_Chip-Seq_BREAST_Human0.95094596
139CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.95001622
140LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.94599098
141PU.1_20513432_ChIP-Seq_Bcells_Mouse0.94384664
142NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.93139129
143YAP1_20516196_ChIP-Seq_MESCs_Mouse0.92606787
144* GATA1_19941827_ChIP-Seq_MEL_Mouse0.92587947
145OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.92088462
146NCOR1_26117541_ChIP-Seq_K562_Human0.91356127
147* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.90895480
148TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.90274365
149* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89327761
150* ETS1_20019798_ChIP-Seq_JURKAT_Human0.89025181
151ER_23166858_ChIP-Seq_MCF-7_Human0.88056177
152SALL4_18804426_ChIP-ChIP_XEN_Mouse0.87896363
153VDR_24787735_ChIP-Seq_THP-1_Human0.87151622
154SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.85800267
155TAF15_26573619_Chip-Seq_HEK293_Human0.85748387
156* TCF4_23295773_ChIP-Seq_U87_Human0.85699861
157SALL4_22934838_ChIP-ChIP_CD34+_Human0.85504322
158GBX2_23144817_ChIP-Seq_PC3_Human0.85399832
159PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.85007094
160BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.84617213
161SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.83655733
162GATA3_26560356_Chip-Seq_TH2_Human0.83527695
163GABP_17652178_ChIP-ChIP_JURKAT_Human0.83130157
164* TP63_23658742_ChIP-Seq_EP156T_Human0.82717117
165EP300_21415370_ChIP-Seq_HL-1_Mouse0.82594268
166MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.80973859
167ELK1_19687146_ChIP-ChIP_HELA_Human0.80616385
168ETS1_22383799_ChIP-Seq_G1ME_Mouse0.78800743
169TCF4_18268006_ChIP-ChIP_LS174T_Human0.78577039
170E2F1_18555785_Chip-Seq_ESCs_Mouse0.76316655
171NANOG_18555785_Chip-Seq_ESCs_Mouse0.75634099
172CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.74885112

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.26736297
2MP0002009_preneoplasia4.11737033
3* MP0001800_abnormal_humoral_immune3.15941561
4MP0000685_abnormal_immune_system3.12201336
5MP0003303_peritoneal_inflammation3.07762473
6MP0002396_abnormal_hematopoietic_system2.99721334
7MP0001790_abnormal_immune_system2.92896567
8MP0005387_immune_system_phenotype2.92896567
9MP0010234_abnormal_vibrissa_follicle2.84093233
10* MP0002452_abnormal_antigen_presenting2.82606462
11MP0003436_decreased_susceptibility_to2.78955217
12MP0005000_abnormal_immune_tolerance2.64523437
13MP0005671_abnormal_response_to2.57332304
14* MP0002723_abnormal_immune_serum2.51934767
15MP0009785_altered_susceptibility_to2.49069639
16* MP0002420_abnormal_adaptive_immunity2.48342924
17* MP0001819_abnormal_immune_cell2.46322247
18MP0002419_abnormal_innate_immunity2.45328258
19MP0005025_abnormal_response_to2.43444003
20* MP0002398_abnormal_bone_marrow2.40923966
21MP0005464_abnormal_platelet_physiology2.30604484
22MP0004808_abnormal_hematopoietic_stem2.30396000
23MP0009278_abnormal_bone_marrow2.28074588
24MP0002148_abnormal_hypersensitivity_rea2.21801033
25* MP0000716_abnormal_immune_system2.14867561
26* MP0000689_abnormal_spleen_morphology2.14808563
27MP0004185_abnormal_adipocyte_glucose1.98949532
28* MP0002722_abnormal_immune_system1.97484512
29MP0001545_abnormal_hematopoietic_system1.96579534
30MP0005397_hematopoietic_system_phenotyp1.96579534
31MP0002405_respiratory_system_inflammati1.92369742
32MP0003300_gastrointestinal_ulcer1.92203596
33MP0004381_abnormal_hair_follicle1.91581074
34MP0005174_abnormal_tail_pigmentation1.89715007
35* MP0002429_abnormal_blood_cell1.88919405
36MP0001853_heart_inflammation1.86006325
37MP0003705_abnormal_hypodermis_morpholog1.85492691
38MP0000465_gastrointestinal_hemorrhage1.83665040
39MP0003763_abnormal_thymus_physiology1.81896686
40MP0001873_stomach_inflammation1.80013477
41MP0010307_abnormal_tumor_latency1.79743453
42MP0003693_abnormal_embryo_hatching1.76179148
43MP0010678_abnormal_skin_adnexa1.76124264
44MP0010155_abnormal_intestine_physiology1.75609682
45MP0010094_abnormal_chromosome_stability1.75484095
46MP0005408_hypopigmentation1.72495028
47MP0002166_altered_tumor_susceptibility1.71977172
48MP0004510_myositis1.68356474
49MP0008057_abnormal_DNA_replication1.66944356
50MP0000490_abnormal_crypts_of1.64208591
51MP0005409_darkened_coat_color1.62490329
52* MP0001845_abnormal_inflammatory_respons1.61845109
53MP0005248_abnormal_Harderian_gland1.58918492
54MP0009333_abnormal_splenocyte_physiolog1.58838632
55MP0003077_abnormal_cell_cycle1.56187838
56MP0000703_abnormal_thymus_morphology1.53452072
57MP0001661_extended_life_span1.53403603
58MP0005058_abnormal_lysosome_morphology1.52886083
59MP0003172_abnormal_lysosome_physiology1.51286935
60MP0003011_delayed_dark_adaptation1.50524948
61MP0010352_gastrointestinal_tract_polyps1.48816423
62MP0006082_CNS_inflammation1.48341895
63MP0000383_abnormal_hair_follicle1.47167286
64MP0003868_abnormal_feces_composition1.44557107
65MP0004130_abnormal_muscle_cell1.40640563
66MP0000569_abnormal_digit_pigmentation1.39225514
67* MP0004947_skin_inflammation1.37928795
68MP0003111_abnormal_nucleus_morphology1.37682807
69MP0003183_abnormal_peptide_metabolism1.36953418
70MP0002006_tumorigenesis1.33776956
71MP0003632_abnormal_nervous_system1.32154477
72MP0005187_abnormal_penis_morphology1.31265433
73MP0008260_abnormal_autophagy1.29356789
74MP0001533_abnormal_skeleton_physiology1.28898421
75MP0003191_abnormal_cellular_cholesterol1.28049426
76MP0003866_abnormal_defecation1.26434336
77MP0002019_abnormal_tumor_incidence1.25190547
78MP0005451_abnormal_body_composition1.24823947
79MP0003656_abnormal_erythrocyte_physiolo1.21458870
80MP0003045_fibrosis1.18679916
81MP0005310_abnormal_salivary_gland1.18629923
82MP0004264_abnormal_extraembryonic_tissu1.18202676
83MP0003724_increased_susceptibility_to1.18043734
84MP0008469_abnormal_protein_level1.17606756
85MP0000733_abnormal_muscle_development1.17102073
86MP0002332_abnormal_exercise_endurance1.15237611
87MP0008058_abnormal_DNA_repair1.14856790
88MP0008007_abnormal_cellular_replicative1.11356985
89MP0003566_abnormal_cell_adhesion1.11277885
90MP0004957_abnormal_blastocyst_morpholog1.10567898
91MP0003221_abnormal_cardiomyocyte_apopto1.10141867
92MP0005076_abnormal_cell_differentiation1.09011991
93MP0000858_altered_metastatic_potential1.08731116
94MP0005666_abnormal_adipose_tissue1.08506220
95MP0000537_abnormal_urethra_morphology1.08187791
96MP0005075_abnormal_melanosome_morpholog1.06525687
97MP0005171_absent_coat_pigmentation1.06524048
98MP0002086_abnormal_extraembryonic_tissu1.06492248
99MP0003448_altered_tumor_morphology1.06119617
100MP0000013_abnormal_adipose_tissue1.03939738
101MP0009840_abnormal_foam_cell1.02115387
102MP0004233_abnormal_muscle_weight0.98463589
103MP0000343_altered_response_to0.96937036
104MP0003984_embryonic_growth_retardation0.95350628
105MP0002088_abnormal_embryonic_growth/wei0.94063924
106MP0003828_pulmonary_edema0.93398051
107MP0000015_abnormal_ear_pigmentation0.93276904
108MP0002095_abnormal_skin_pigmentation0.92123096
109MP0000427_abnormal_hair_cycle0.92005099
110MP0000313_abnormal_cell_death0.91961473
111MP0003890_abnormal_embryonic-extraembry0.90661291
112MP0000350_abnormal_cell_proliferation0.90571187
113MP0002075_abnormal_coat/hair_pigmentati0.88394778
114MP0002092_abnormal_eye_morphology0.87952016
115MP0000428_abnormal_craniofacial_morphol0.87690183
116MP0001851_eye_inflammation0.84636334
117MP0001186_pigmentation_phenotype0.84503155
118MP0003690_abnormal_glial_cell0.83256538
119MP0004036_abnormal_muscle_relaxation0.82451526
120MP0005275_abnormal_skin_tensile0.82298841
121MP0000377_abnormal_hair_follicle0.78377867
122MP0005023_abnormal_wound_healing0.75546781
123MP0005380_embryogenesis_phenotype0.75180157
124MP0001672_abnormal_embryogenesis/_devel0.75180157
125MP0000371_diluted_coat_color0.74328495
126MP0004084_abnormal_cardiac_muscle0.73766330
127MP0001663_abnormal_digestive_system0.72654224
128MP0005375_adipose_tissue_phenotype0.69382994
129MP0009764_decreased_sensitivity_to0.69346452
130MP0002168_other_aberrant_phenotype0.69214950
131MP0000003_abnormal_adipose_tissue0.68767610
132* MP0002933_joint_inflammation0.68176308
133MP0005384_cellular_phenotype0.66883060
134MP0003950_abnormal_plasma_membrane0.66554799
135MP0001730_embryonic_growth_arrest0.64794169
136MP0005621_abnormal_cell_physiology0.64241952
137MP0009763_increased_sensitivity_to0.64210073
138MP0000627_abnormal_mammary_gland0.64149629
139MP0005391_vision/eye_phenotype0.63755293
140MP0005253_abnormal_eye_physiology0.63628489
141MP0009115_abnormal_fat_cell0.63366104
142MP0003329_amyloid_beta_deposits0.63215486
143MP0004134_abnormal_chest_morphology0.62744500
144MP0002697_abnormal_eye_size0.62365957
145MP0001915_intracranial_hemorrhage0.61833279
146MP0000477_abnormal_intestine_morphology0.61804859
147MP0003943_abnormal_hepatobiliary_system0.61401470
148MP0002998_abnormal_bone_remodeling0.61215106
149MP0005220_abnormal_exocrine_pancreas0.61157978
150MP0003075_altered_response_to0.60827199
151MP0006054_spinal_hemorrhage0.60788224
152MP0000249_abnormal_blood_vessel0.59439937
153MP0003631_nervous_system_phenotype0.58394202
154MP0005166_decreased_susceptibility_to0.57436074
155MP0003453_abnormal_keratinocyte_physiol0.55827709
156MP0008873_increased_physiological_sensi0.55450520
157MP0002877_abnormal_melanocyte_morpholog0.55095458
158MP0003091_abnormal_cell_migration0.51988825
159MP0000598_abnormal_liver_morphology0.51692066

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)5.41014661
2Recurrent bacterial skin infections (HP:0005406)4.99743062
3Agammaglobulinemia (HP:0004432)4.87360785
4* Cellulitis (HP:0100658)4.74099280
5Eczematoid dermatitis (HP:0000976)4.50057359
6Subacute progressive viral hepatitis (HP:0006572)4.40368889
7Recurrent viral infections (HP:0004429)4.19278924
8Papillary thyroid carcinoma (HP:0002895)4.07671136
9Myositis (HP:0100614)4.00288216
10Meningitis (HP:0001287)3.98386554
11Chronic otitis media (HP:0000389)3.95228363
12Recurrent bronchitis (HP:0002837)3.94547580
13Thrombocytosis (HP:0001894)3.86225029
14Recurrent fungal infections (HP:0002841)3.84163464
15Elevated erythrocyte sedimentation rate (HP:0003565)3.76332825
16Abnormal delayed hypersensitivity skin test (HP:0002963)3.67594088
17* IgM deficiency (HP:0002850)3.66472144
18Dysmetric saccades (HP:0000641)3.63386399
19Mediastinal lymphadenopathy (HP:0100721)3.49955986
20Gastrointestinal stroma tumor (HP:0100723)3.46005085
21Osteomyelitis (HP:0002754)3.43098782
22Recurrent skin infections (HP:0001581)3.37771259
23Recurrent gram-negative bacterial infections (HP:0005420)3.27548584
24Vasculitis (HP:0002633)3.24924091
25Verrucae (HP:0200043)3.23234582
26Papilloma (HP:0012740)3.23234582
27Abnormality of macrophages (HP:0004311)3.22254357
28Panhypogammaglobulinemia (HP:0003139)3.18006240
29Obstructive lung disease (HP:0006536)3.14639826
30Chronic obstructive pulmonary disease (HP:0006510)3.14639826
31Orchitis (HP:0100796)3.03860938
32* Gastrointestinal inflammation (HP:0004386)3.02979648
33Petechiae (HP:0000967)3.00612746
34Lymphopenia (HP:0001888)2.99732337
35Abnormality of T cell physiology (HP:0011840)2.98245752
36Recurrent pneumonia (HP:0006532)2.98244522
37* Inflammation of the large intestine (HP:0002037)2.96233770
38Osteolytic defects of the phalanges of the hand (HP:0009771)2.95130620
39Osteolytic defects of the hand bones (HP:0009699)2.95130620
40Abnormality of cells of the lymphoid lineage (HP:0012140)2.94810035
41Autoimmune thrombocytopenia (HP:0001973)2.93577211
42Recurrent cutaneous fungal infections (HP:0011370)2.88959981
43Chronic mucocutaneous candidiasis (HP:0002728)2.88959981
44Recurrent lower respiratory tract infections (HP:0002783)2.84332999
45Optic neuritis (HP:0100653)2.81192083
46Retrobulbar optic neuritis (HP:0100654)2.81192083
47Thyroid carcinoma (HP:0002890)2.79468999
48* Colitis (HP:0002583)2.79376608
49Asymmetry of the thorax (HP:0001555)2.78913464
50Sandal gap (HP:0001852)2.78818435
51Recurrent sinusitis (HP:0011108)2.77872766
52Spontaneous hematomas (HP:0007420)2.77065205
53Prolonged bleeding time (HP:0003010)2.76854302
54T lymphocytopenia (HP:0005403)2.75684083
55Germ cell neoplasia (HP:0100728)2.75541100
56Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)2.75188882
57Absent frontal sinuses (HP:0002688)2.74093521
58Reticulocytopenia (HP:0001896)2.70428269
59Abnormality of the fingertips (HP:0001211)2.67843678
60Neonatal hypoglycemia (HP:0001998)2.66311738
61Deep philtrum (HP:0002002)2.64434569
62Abnormality of B cell number (HP:0010975)2.62094683
63B lymphocytopenia (HP:0010976)2.62094683
64Nasal polyposis (HP:0100582)2.61598614
65Abnormal platelet function (HP:0011869)2.59620418
66Impaired platelet aggregation (HP:0003540)2.59620418
67Chronic sinusitis (HP:0011109)2.59516412
68Abnormality of T cells (HP:0002843)2.58761655
69Spinal cord lesions (HP:0100561)2.54279267
70Syringomyelia (HP:0003396)2.54279267
71Sepsis (HP:0100806)2.52230707
72Emphysema (HP:0002097)2.49937170
73Pustule (HP:0200039)2.47474019
74Arterial thrombosis (HP:0004420)2.47139375
75Heterotopia (HP:0002282)2.47034956
76Agnosia (HP:0010524)2.44323167
77Increased IgE level (HP:0003212)2.44264549
78Abnormality of the nasal mucosa (HP:0000433)2.42428429
79Periodontitis (HP:0000704)2.41778667
80Scanning speech (HP:0002168)2.41483839
81Gingivitis (HP:0000230)2.40808788
82Hypopigmentation of the fundus (HP:0007894)2.40277299
83Vacuolated lymphocytes (HP:0001922)2.39091809
84Lymphoma (HP:0002665)2.37935591
85Micronodular cirrhosis (HP:0001413)2.37762230
86Short chin (HP:0000331)2.37323087
87Large earlobe (HP:0009748)2.34951316
88Abnormality of T cell number (HP:0011839)2.34864065
89Termporal pattern (HP:0011008)2.32851891
90Insidious onset (HP:0003587)2.32851891
91Hematochezia (HP:0002573)2.32098476
92Abnormality of cells of the erythroid lineage (HP:0012130)2.31644372
93Chest pain (HP:0100749)2.30136304
94Skin ulcer (HP:0200042)2.30087875
95Overgrowth (HP:0001548)2.28702178
96Encephalitis (HP:0002383)2.27584103
97Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)2.26785902
98Submucous cleft hard palate (HP:0000176)2.25672088
99Conjunctival telangiectasia (HP:0000524)2.25428906
100Ankyloglossia (HP:0010296)2.24563699
101Abnormality of the distal phalanx of the thumb (HP:0009617)2.23839197
102Flat acetabular roof (HP:0003180)2.23382994
103Narrow palate (HP:0000189)2.21818194
104Increased cerebral lipofuscin (HP:0011813)2.18898646
105Epistaxis (HP:0000421)2.18466808
106Restrictive lung disease (HP:0002091)2.17704933
107Leukopenia (HP:0001882)2.17661352
108IgG deficiency (HP:0004315)2.17555765
109Urticaria (HP:0001025)2.17538818
110Abnormal number of erythroid precursors (HP:0012131)2.14892767
111Bronchitis (HP:0012387)2.13956899
112Truncal obesity (HP:0001956)2.12734153
113Dislocated radial head (HP:0003083)2.12660762
114Prominent nose (HP:0000448)2.11569864
115Relative macrocephaly (HP:0004482)2.11176942
116Increased density of long bones (HP:0006392)2.11171302
117Leukocytosis (HP:0001974)2.09693405
118Abnormal glucose tolerance (HP:0001952)2.09318942
119Pulmonary infiltrates (HP:0002113)2.08591581
120Abnormality of the vasculature of the conjunctiva (HP:0008054)2.08057064
121Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.08029489
122Amaurosis fugax (HP:0100576)2.07532763
123Acute myeloid leukemia (HP:0004808)2.06978977
124Fair hair (HP:0002286)2.06784621
125Hepatitis (HP:0012115)2.06070556
126Generalized hypopigmentation of hair (HP:0011358)2.02001560
127Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.01960477
128Abnormality of the epiphyses of the hand (HP:0005924)2.01643645
129Systemic lupus erythematosus (HP:0002725)2.01413082
130Myelodysplasia (HP:0002863)2.01177716
131Scotoma (HP:0000575)1.99842268
132Fatigue (HP:0012378)1.99135641
133Gingival bleeding (HP:0000225)1.99070244
134Difficulty running (HP:0009046)1.98297913
135Hypoplasia of the iris (HP:0007676)1.98043037
136Increased neuronal autofluorescent lipopigment (HP:0002074)1.97815950
137Keratoconjunctivitis sicca (HP:0001097)1.97708691
138Vertebral arch anomaly (HP:0008438)1.97572437
139Albinism (HP:0001022)1.97351591
140Menstrual irregularities (HP:0000858)1.97286210
141Pallor (HP:0000980)1.96541030
142Aortic aneurysm (HP:0004942)1.96257706
143Medulloblastoma (HP:0002885)1.96195199
144Autoimmune hemolytic anemia (HP:0001890)1.95924022
145Thoracic kyphosis (HP:0002942)1.95160519
146Chromosomal breakage induced by crosslinking agents (HP:0003221)1.94464252
147Abnormality of oral frenula (HP:0000190)1.93913632
14811 pairs of ribs (HP:0000878)1.92808919
149Blue irides (HP:0000635)1.92555641
150Abnormality of the thoracic spine (HP:0100711)1.91916064
151Viral hepatitis (HP:0006562)1.91902162
152Granulocytopenia (HP:0001913)1.91891333
153Renovascular hypertension (HP:0100817)1.91594697
154Eosinophilia (HP:0001880)1.90955047
155Abnormality involving the epiphyses of the upper limbs (HP:0003839)1.90529030
156Skin rash (HP:0000988)1.88180083
157Neutropenia (HP:0001875)1.86221703
158Abnormality of the radial head (HP:0003995)1.86195502
159Curly hair (HP:0002212)1.86189156
160Persistence of primary teeth (HP:0006335)1.84960750
161Abnormal platelet volume (HP:0011876)1.84903747
162Gastrointestinal carcinoma (HP:0002672)1.84326650
163Malignant gastrointestinal tract tumors (HP:0006749)1.84326650
164Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.83964532
165Macroorchidism (HP:0000053)1.82946057
166Thoracolumbar scoliosis (HP:0002944)1.82559076
167Glucose intolerance (HP:0000833)1.81648550
168Bladder neoplasm (HP:0009725)1.80914130
169Bladder carcinoma (HP:0002862)1.80914130
170Broad ribs (HP:0000885)1.79462244
171Chromsome breakage (HP:0040012)1.78888334
172Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.77291813
173Transitional cell carcinoma of the bladder (HP:0006740)1.77248852
174Short nail (HP:0001799)1.77009228
175Acute lymphatic leukemia (HP:0006721)1.75945823
176Cubitus valgus (HP:0002967)1.75856814
177Leiomyosarcoma (HP:0100243)1.75407416
178Uterine leiomyosarcoma (HP:0002891)1.75407416
179Resting tremor (HP:0002322)1.70257325
180Missing ribs (HP:0000921)1.68674919
181Sparse lateral eyebrow (HP:0005338)1.68126407
182Coarse hair (HP:0002208)1.67895253
183Central scotoma (HP:0000603)1.67091686
184Short 4th metacarpal (HP:0010044)1.66210451
185Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.66210451
186Protruding tongue (HP:0010808)1.64172114
187Nephroblastoma (Wilms tumor) (HP:0002667)1.63722516
188Esophageal varix (HP:0002040)1.61184190
189Thick eyebrow (HP:0000574)1.59198036
190Abnormality of chromosome stability (HP:0003220)1.57839118

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.76509647
2TLK13.44786728
3ZAK3.24933017
4EEF2K3.06903138
5BLK2.75577335
6KIT2.68776395
7ERN12.67096408
8AKT32.67000652
9CSF1R2.65350860
10MAP3K102.62909406
11FRK2.44872945
12* BTK2.14518096
13IRAK42.03954455
14STK101.97315402
15PKN21.97048860
16JAK31.95682512
17MAP3K21.94831625
18RIPK41.92471637
19TBK11.89762645
20TYK21.89731018
21GRK61.82350051
22* SYK1.81483386
23PIK3CG1.80809517
24FLT31.74186129
25LRRK21.66455228
26SGK21.64897426
27TEC1.63287442
28IRAK31.63199601
29MAP3K141.62680600
30MST1R1.61863191
31ZAP701.61176995
32RPS6KA51.59802745
33TGFBR21.50548547
34FES1.50216588
35IKBKE1.50213524
36CDK121.44629439
37RET1.43838586
38MAP2K31.43043728
39IKBKB1.43007964
40MAP3K61.40311665
41PIM11.39130600
42NEK21.39073859
43SGK31.38290806
44CAMKK21.38033905
45NEK61.37248371
46TAOK31.36416576
47PBK1.35547376
48EPHA31.34719473
49CDC71.34129291
50NME21.32875643
51MATK1.29185055
52ICK1.24797787
53TRIB31.20988770
54RPS6KB21.20427964
55RPS6KA41.18583776
56CLK11.18320644
57WEE11.16033242
58* LYN1.15872206
59PDGFRB1.15744457
60* HCK1.12286079
61MELK1.11288135
62CDK41.10991175
63BMPR21.08833085
64MAP3K131.07979697
65SCYL21.05625996
66TGFBR11.03570362
67SGK2231.03017367
68SGK4941.03017367
69EPHB11.02940140
70LATS11.02892805
71CSK1.01908133
72* LCK1.01767833
73JAK11.01259956
74STK41.00516338
75MTOR0.99650795
76PDGFRA0.99428918
77PIK3CA0.99261253
78SIK20.96828698
79MARK20.94951522
80CHUK0.91580891
81WNK10.89923016
82MAP3K40.89619991
83MET0.87793667
84MAP2K40.86005614
85TXK0.85245413
86PIM20.81724191
87MAP3K80.80594545
88ITK0.78234220
89RPS6KB10.77168447
90ERBB20.75759375
91CAMK40.74493200
92MARK30.73719323
93PAK40.72943158
94PRPF4B0.71711388
95CDK70.69859804
96ATR0.69225731
97ACVR1B0.69165267
98EIF2AK30.69117496
99PRKAA20.68679208
100CAMK1D0.68043680
101FGFR40.67868178
102IRAK10.67687639
103CDK60.66733339
104IRAK20.66068078
105SGK10.65875050
106ALK0.65442107
107MAPKAPK30.64759963
108PTK60.63868340
109CAMKK10.63044917
110TRPM70.62499601
111RAF10.61283082
112TESK20.59976331
113FER0.59889356
114FGFR30.59818087
115MAPKAPK20.58744675
116RPS6KA60.58348934
117MAPK40.58154283
118JAK20.56359057
119DYRK30.56033169
120TSSK60.55853526
121STK390.55189220
122PASK0.54351140
123BRSK20.53953392
124HIPK20.53542644
125CSNK1A1L0.53343179
126RPS6KL10.50929920
127RPS6KC10.50929920
128PRKAA10.50409275
129ATM0.50372510
130TNK20.46423202
131CHEK20.46189046
132BUB10.45504255
133EIF2AK10.45464952
134MAPK110.43744520
135VRK10.43569951
136ERBB30.42877833
137ABL10.42325698
138MAP3K10.42275987
139STK38L0.42027271
140FGR0.41906544
141BRD40.41498745
142CDK90.40955800
143PDPK10.40475456
144MAP3K110.39138658
145MAP3K70.38083060
146CAMK1G0.38068630
147CDK80.37641787
148TTN0.36049594
149STK240.35943074
150PDK10.35745669
151AURKB0.35191735
152CHEK10.34756831
153KDR0.34392436
154RIPK10.34381052
155DAPK30.33988945
156MKNK10.33155963
157KSR10.32564180
158NEK90.32435363
159KSR20.32104804
160NLK0.30652837

Predicted pathways (KEGG)

RankGene SetZ-score
1Alcoholism_Homo sapiens_hsa050344.01295972
2* B cell receptor signaling pathway_Homo sapiens_hsa046623.17070522
3Primary immunodeficiency_Homo sapiens_hsa053402.99775386
4DNA replication_Homo sapiens_hsa030302.84919375
5Leishmaniasis_Homo sapiens_hsa051402.64414706
6Antigen processing and presentation_Homo sapiens_hsa046122.21596178
7Mismatch repair_Homo sapiens_hsa034302.17498468
8* NF-kappa B signaling pathway_Homo sapiens_hsa040642.16990170
9* Osteoclast differentiation_Homo sapiens_hsa043802.14759716
10Base excision repair_Homo sapiens_hsa034102.08924779
11Ribosome_Homo sapiens_hsa030101.97904995
12Intestinal immune network for IgA production_Homo sapiens_hsa046721.84618940
13Measles_Homo sapiens_hsa051621.82781017
14Hematopoietic cell lineage_Homo sapiens_hsa046401.79471526
15* Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.76732280
16Endometrial cancer_Homo sapiens_hsa052131.73969756
17Toll-like receptor signaling pathway_Homo sapiens_hsa046201.73436766
18Herpes simplex infection_Homo sapiens_hsa051681.71067854
19Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.65861183
20Legionellosis_Homo sapiens_hsa051341.62924917
21Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.57124164
22* Phosphatidylinositol signaling system_Homo sapiens_hsa040701.56049649
23NOD-like receptor signaling pathway_Homo sapiens_hsa046211.54281762
24Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.51590235
25Homologous recombination_Homo sapiens_hsa034401.50303563
26Acute myeloid leukemia_Homo sapiens_hsa052211.49878310
27RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.48909548
28Thyroid cancer_Homo sapiens_hsa052161.48584987
29Tuberculosis_Homo sapiens_hsa051521.44986944
30* Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.43404365
31Other glycan degradation_Homo sapiens_hsa005111.42466076
32Shigellosis_Homo sapiens_hsa051311.41834002
33Influenza A_Homo sapiens_hsa051641.40383774
34* Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.38793705
35Non-homologous end-joining_Homo sapiens_hsa034501.36686354
36Pertussis_Homo sapiens_hsa051331.36146740
37Renal cell carcinoma_Homo sapiens_hsa052111.35865110
38Apoptosis_Homo sapiens_hsa042101.35537726
39Toxoplasmosis_Homo sapiens_hsa051451.34714565
40Glycosaminoglycan degradation_Homo sapiens_hsa005311.34266237
41* Inositol phosphate metabolism_Homo sapiens_hsa005621.33411561
42Spliceosome_Homo sapiens_hsa030401.33113246
43Chronic myeloid leukemia_Homo sapiens_hsa052201.31732446
44Staphylococcus aureus infection_Homo sapiens_hsa051501.31519217
45Jak-STAT signaling pathway_Homo sapiens_hsa046301.30802511
46Transcriptional misregulation in cancer_Homo sapiens_hsa052021.29602930
47* Glioma_Homo sapiens_hsa052141.27319589
48Prostate cancer_Homo sapiens_hsa052151.26018562
49Hepatitis B_Homo sapiens_hsa051611.25204843
50Malaria_Homo sapiens_hsa051441.19115808
51* Epstein-Barr virus infection_Homo sapiens_hsa051691.15680019
52Cell cycle_Homo sapiens_hsa041101.15531420
53Adherens junction_Homo sapiens_hsa045201.15002442
54Chemokine signaling pathway_Homo sapiens_hsa040621.14956689
55* Leukocyte transendothelial migration_Homo sapiens_hsa046701.14383268
56Longevity regulating pathway - mammal_Homo sapiens_hsa042111.13827676
57Dorso-ventral axis formation_Homo sapiens_hsa043201.12812699
58Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.09651844
59Viral carcinogenesis_Homo sapiens_hsa052031.09403199
60TNF signaling pathway_Homo sapiens_hsa046681.09144562
61Focal adhesion_Homo sapiens_hsa045101.08323874
62* ErbB signaling pathway_Homo sapiens_hsa040121.08265991
63* Thyroid hormone signaling pathway_Homo sapiens_hsa049191.07074984
64Choline metabolism in cancer_Homo sapiens_hsa052311.04155442
65Lysine degradation_Homo sapiens_hsa003101.02150997
66Nucleotide excision repair_Homo sapiens_hsa034201.02113829
67Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.02087368
68T cell receptor signaling pathway_Homo sapiens_hsa046600.99703318
69* Proteoglycans in cancer_Homo sapiens_hsa052050.98671406
70Adipocytokine signaling pathway_Homo sapiens_hsa049200.97987881
71Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.96976834
72* Platelet activation_Homo sapiens_hsa046110.96753819
73Pancreatic cancer_Homo sapiens_hsa052120.96419495
74Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.96294797
75Salmonella infection_Homo sapiens_hsa051320.96033994
76One carbon pool by folate_Homo sapiens_hsa006700.94535839
77Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.94330482
78Asthma_Homo sapiens_hsa053100.91980565
79Type II diabetes mellitus_Homo sapiens_hsa049300.91772203
80RNA transport_Homo sapiens_hsa030130.90350359
81p53 signaling pathway_Homo sapiens_hsa041150.89080126
82Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.88955147
83Allograft rejection_Homo sapiens_hsa053300.88675665
84Lysosome_Homo sapiens_hsa041420.88147070
85HTLV-I infection_Homo sapiens_hsa051660.87294804
86Fatty acid biosynthesis_Homo sapiens_hsa000610.86542999
87Melanoma_Homo sapiens_hsa052180.86482291
88Central carbon metabolism in cancer_Homo sapiens_hsa052300.82702392
89GnRH signaling pathway_Homo sapiens_hsa049120.81838221
90Viral myocarditis_Homo sapiens_hsa054160.81194452
91Fanconi anemia pathway_Homo sapiens_hsa034600.79710105
92Pyrimidine metabolism_Homo sapiens_hsa002400.79386236
93ABC transporters_Homo sapiens_hsa020100.77609111
94Small cell lung cancer_Homo sapiens_hsa052220.77523658
95Sphingolipid signaling pathway_Homo sapiens_hsa040710.77327155
96* Neurotrophin signaling pathway_Homo sapiens_hsa047220.76848171
97Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.76786496
98Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.76434488
99Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.76247335
100ECM-receptor interaction_Homo sapiens_hsa045120.75812496
101Systemic lupus erythematosus_Homo sapiens_hsa053220.75190732
102Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.73609316
103Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.72788792
104* AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.71929753
105Hepatitis C_Homo sapiens_hsa051600.71021807
106Bladder cancer_Homo sapiens_hsa052190.71012939
107Estrogen signaling pathway_Homo sapiens_hsa049150.68980003
108Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.68381569
109Pentose phosphate pathway_Homo sapiens_hsa000300.67909115
110Insulin signaling pathway_Homo sapiens_hsa049100.67298847
111Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.66545051
112* Phospholipase D signaling pathway_Homo sapiens_hsa040720.66444432
113* Non-small cell lung cancer_Homo sapiens_hsa052230.66174320
114Long-term potentiation_Homo sapiens_hsa047200.66063153
115TGF-beta signaling pathway_Homo sapiens_hsa043500.65777702
116* Pathways in cancer_Homo sapiens_hsa052000.64597764
117RNA degradation_Homo sapiens_hsa030180.63478862
118Colorectal cancer_Homo sapiens_hsa052100.62132429
119Prolactin signaling pathway_Homo sapiens_hsa049170.61131473
120Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.59031948
121Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.58228253
122Carbohydrate digestion and absorption_Homo sapiens_hsa049730.57229614
123African trypanosomiasis_Homo sapiens_hsa051430.57015353
124Cholinergic synapse_Homo sapiens_hsa047250.56290110
125cGMP-PKG signaling pathway_Homo sapiens_hsa040220.55926186
126Graft-versus-host disease_Homo sapiens_hsa053320.55406856
127Vascular smooth muscle contraction_Homo sapiens_hsa042700.55045193
128Notch signaling pathway_Homo sapiens_hsa043300.54403456
129Caffeine metabolism_Homo sapiens_hsa002320.53407087
130Circadian rhythm_Homo sapiens_hsa047100.53405981
131AMPK signaling pathway_Homo sapiens_hsa041520.53071839
132Phagosome_Homo sapiens_hsa041450.49981028
133* MicroRNAs in cancer_Homo sapiens_hsa052060.48224202
134* HIF-1 signaling pathway_Homo sapiens_hsa040660.47802243
135mRNA surveillance pathway_Homo sapiens_hsa030150.46755902
136Amoebiasis_Homo sapiens_hsa051460.46580330
137N-Glycan biosynthesis_Homo sapiens_hsa005100.45434492
138MAPK signaling pathway_Homo sapiens_hsa040100.44683180
139RNA polymerase_Homo sapiens_hsa030200.44548443
140Rap1 signaling pathway_Homo sapiens_hsa040150.44243876
141Renin secretion_Homo sapiens_hsa049240.43516333
142* Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.42719750
143Tight junction_Homo sapiens_hsa045300.41837820
144PI3K-Akt signaling pathway_Homo sapiens_hsa041510.41826949
145Rheumatoid arthritis_Homo sapiens_hsa053230.39364524
146mTOR signaling pathway_Homo sapiens_hsa041500.38731214
147* VEGF signaling pathway_Homo sapiens_hsa043700.37802796
148Insulin resistance_Homo sapiens_hsa049310.33492242
149FoxO signaling pathway_Homo sapiens_hsa040680.33192253
150Proteasome_Homo sapiens_hsa030500.32218845
151Endocytosis_Homo sapiens_hsa041440.31956011
152Regulation of actin cytoskeleton_Homo sapiens_hsa048100.31768355

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