PLCH1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: PLCH1 is a member of the PLC-eta family of the phosphoinositide-specific phospholipase C (PLC) superfamily of enzymes that cleave phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) to generate second messengers inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG) (Hwang et al., 2005 [PubMed 15702972]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axonemal dynein complex assembly (GO:0070286)6.37333679
2epithelial cilium movement (GO:0003351)6.28089845
3cilium movement (GO:0003341)6.22683813
4epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)6.12837652
5cilium or flagellum-dependent cell motility (GO:0001539)5.75605215
6intraciliary transport (GO:0042073)4.71182095
7regulation of cilium movement (GO:0003352)4.71009804
8auditory behavior (GO:0031223)4.41904546
9microtubule depolymerization (GO:0007019)4.22644839
10motile cilium assembly (GO:0044458)4.18952641
11positive regulation of synaptic transmission, dopaminergic (GO:0032226)4.13856365
12regulation of short-term neuronal synaptic plasticity (GO:0048172)4.13322679
13righting reflex (GO:0060013)4.11160665
14presynaptic membrane assembly (GO:0097105)4.03468708
15axoneme assembly (GO:0035082)4.02197054
16nonmotile primary cilium assembly (GO:0035058)3.95880394
17cilium assembly (GO:0042384)3.84478595
18cilium organization (GO:0044782)3.82839512
19positive regulation of gastrulation (GO:2000543)3.74972991
20positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.70806626
21presynaptic membrane organization (GO:0097090)3.67985118
22regulation of rhodopsin mediated signaling pathway (GO:0022400)3.61130094
23photoreceptor cell maintenance (GO:0045494)3.61110293
24rhodopsin mediated signaling pathway (GO:0016056)3.60388385
25photoreceptor cell development (GO:0042461)3.53995653
26cerebellar Purkinje cell differentiation (GO:0021702)3.50641953
27response to auditory stimulus (GO:0010996)3.49132762
28regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.40038309
29microtubule polymerization or depolymerization (GO:0031109)3.39014632
30mechanosensory behavior (GO:0007638)3.38403878
31layer formation in cerebral cortex (GO:0021819)3.36921984
32establishment of nucleus localization (GO:0040023)3.34920250
33cerebellum development (GO:0021549)3.34631031
34microtubule bundle formation (GO:0001578)3.33475548
35protein localization to cilium (GO:0061512)3.32561197
36axonal fasciculation (GO:0007413)3.32185396
37retinal rod cell development (GO:0046548)3.31698162
38cilium morphogenesis (GO:0060271)3.31072598
39response to pheromone (GO:0019236)3.30381543
40lateral sprouting from an epithelium (GO:0060601)3.29564138
41eye photoreceptor cell development (GO:0042462)3.28865172
42neuron fate determination (GO:0048664)3.26710344
43retinal ganglion cell axon guidance (GO:0031290)3.26248041
44dendritic spine morphogenesis (GO:0060997)3.24881141
45nucleobase catabolic process (GO:0046113)3.24824287
46innervation (GO:0060384)3.18165288
47left/right pattern formation (GO:0060972)3.16942467
48limb bud formation (GO:0060174)3.15764562
49dorsal/ventral axis specification (GO:0009950)3.15433239
50locomotory exploration behavior (GO:0035641)3.15147231
51neuronal stem cell maintenance (GO:0097150)3.12647753
52embryonic foregut morphogenesis (GO:0048617)3.10721624
53olfactory bulb development (GO:0021772)3.10515871
54synaptic vesicle maturation (GO:0016188)3.10509518
55ventricular system development (GO:0021591)3.10088473
56retinal cone cell development (GO:0046549)3.07961300
57negative regulation of axon guidance (GO:1902668)3.07892743
58cerebellar Purkinje cell layer development (GO:0021680)3.00997287
59cellular component assembly involved in morphogenesis (GO:0010927)2.99565795
60synaptic vesicle docking involved in exocytosis (GO:0016081)2.96519798
61cranial nerve morphogenesis (GO:0021602)2.95139049
62smoothened signaling pathway (GO:0007224)2.94636576
63behavioral response to nicotine (GO:0035095)2.90870765
64pre-miRNA processing (GO:0031054)2.89182472
65neuron cell-cell adhesion (GO:0007158)2.88911432
66stress granule assembly (GO:0034063)2.88276466
67otic vesicle formation (GO:0030916)2.87893773
68regulation of synaptic vesicle exocytosis (GO:2000300)2.87763921
69central nervous system projection neuron axonogenesis (GO:0021952)2.86901662
70microtubule-based movement (GO:0007018)2.85619307
71cell migration in hindbrain (GO:0021535)2.85613938
72synaptic vesicle exocytosis (GO:0016079)2.83529233
73regulation of microtubule-based movement (GO:0060632)2.83455163
74appendage development (GO:0048736)2.82936492
75limb development (GO:0060173)2.82936492
76neuron recognition (GO:0008038)2.78119957
77paraxial mesoderm development (GO:0048339)2.75526867
78nucleus localization (GO:0051647)2.70827104
79hindbrain development (GO:0030902)2.70167572
80cochlea development (GO:0090102)2.69802099
81pyrimidine nucleobase catabolic process (GO:0006208)2.69626285
82glutamate secretion (GO:0014047)2.69403148
83negative regulation of microtubule polymerization (GO:0031115)2.69204594
84regulation of non-canonical Wnt signaling pathway (GO:2000050)2.68909687
85establishment of tissue polarity (GO:0007164)2.66705855
86establishment of planar polarity (GO:0001736)2.66705855
87GMP metabolic process (GO:0046037)2.64589441
88protein polyglutamylation (GO:0018095)2.64535357
89postsynaptic membrane organization (GO:0001941)2.63507919
90cell communication by electrical coupling (GO:0010644)2.61762113
91cell proliferation in forebrain (GO:0021846)2.60209827
92DNA ligation (GO:0006266)2.59696497
93retina layer formation (GO:0010842)2.57904027
94intra-S DNA damage checkpoint (GO:0031573)2.55493650
95membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.53739244
96neurotransmitter secretion (GO:0007269)2.53261480
97kidney morphogenesis (GO:0060993)2.53001549
98regulation of synaptic vesicle transport (GO:1902803)2.52520361
99apical protein localization (GO:0045176)2.52169900
100somite development (GO:0061053)2.51972433
101radial glial cell differentiation (GO:0060019)2.50456115
102nucleosome disassembly (GO:0006337)2.49656445
103protein-DNA complex disassembly (GO:0032986)2.49656445
104regulation of collateral sprouting (GO:0048670)2.48971346
105left/right axis specification (GO:0070986)2.48826904
106regulation of sister chromatid cohesion (GO:0007063)2.48676082
107eye photoreceptor cell differentiation (GO:0001754)2.48445703
108photoreceptor cell differentiation (GO:0046530)2.48445703
109hair cell differentiation (GO:0035315)2.48201044
110resolution of meiotic recombination intermediates (GO:0000712)2.47834091
111cell differentiation in hindbrain (GO:0021533)2.47784895
112phototransduction (GO:0007602)2.47485395
113axon extension involved in axon guidance (GO:0048846)2.45531475
114neuron projection extension involved in neuron projection guidance (GO:1902284)2.45531475
115centriole replication (GO:0007099)2.45199190
116sensory perception of light stimulus (GO:0050953)2.44669184
117membrane repolarization during action potential (GO:0086011)2.44564840
118cranial nerve development (GO:0021545)2.44397240
119cell projection assembly (GO:0030031)2.43935371
120visual perception (GO:0007601)2.43805129
121primitive streak formation (GO:0090009)2.43486600
122synaptic vesicle endocytosis (GO:0048488)2.42927511
123anatomical structure arrangement (GO:0048532)2.42292822
124membrane hyperpolarization (GO:0060081)2.42007225
125regulation of axon guidance (GO:1902667)2.41699222
126cerebral cortex development (GO:0021987)2.40475152
127dopaminergic neuron differentiation (GO:0071542)2.39926838
128negative regulation of translation, ncRNA-mediated (GO:0040033)2.39459597
129regulation of translation, ncRNA-mediated (GO:0045974)2.39459597
130negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.39459597
131protein localization to synapse (GO:0035418)2.39153569
132calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.37821948
133regulation of centriole replication (GO:0046599)2.36518862
134lung-associated mesenchyme development (GO:0060484)2.35819626
135negative regulation of axon extension involved in axon guidance (GO:0048843)2.35724474
136neuroblast proliferation (GO:0007405)2.35674806
137detection of light stimulus (GO:0009583)2.34832299
138planar cell polarity pathway involved in neural tube closure (GO:0090179)2.34816114
139dosage compensation (GO:0007549)2.34779083
140regulation of growth hormone secretion (GO:0060123)2.34653677
141vocalization behavior (GO:0071625)2.34185718
142positive regulation of neuroblast proliferation (GO:0002052)2.33640062
143interkinetic nuclear migration (GO:0022027)2.32861597
144cellular potassium ion homeostasis (GO:0030007)2.32836053
145phototransduction, visible light (GO:0007603)2.32686491
146determination of left/right symmetry (GO:0007368)2.32159690
147G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.31845638
148determination of bilateral symmetry (GO:0009855)2.31385089
149detection of light stimulus involved in sensory perception (GO:0050962)2.30890004
150detection of light stimulus involved in visual perception (GO:0050908)2.30890004
151establishment of integrated proviral latency (GO:0075713)2.30612239
152ephrin receptor signaling pathway (GO:0048013)2.30318607
153regulation of gene silencing by RNA (GO:0060966)2.30041014
154regulation of posttranscriptional gene silencing (GO:0060147)2.30041014
155regulation of gene silencing by miRNA (GO:0060964)2.30041014
156cardiovascular system development (GO:0072358)2.29879243
157organ growth (GO:0035265)2.29604253
158forebrain neuron differentiation (GO:0021879)2.29237538
159homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156)2.29155726
160spinal cord association neuron differentiation (GO:0021527)2.28871433
161inner ear receptor cell development (GO:0060119)2.28587585
162regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.28237927
163hippocampus development (GO:0021766)2.27861962
164exploration behavior (GO:0035640)2.27455147
165lateral ventricle development (GO:0021670)2.27388275
166detection of visible light (GO:0009584)2.27359090
167short-term memory (GO:0007614)2.26706572
168retina development in camera-type eye (GO:0060041)2.26680976
169specification of symmetry (GO:0009799)2.23774293
170transmission of nerve impulse (GO:0019226)2.23722238
171chromatin remodeling at centromere (GO:0031055)2.22087641
172regulation of development, heterochronic (GO:0040034)2.21543837
173gastrulation with mouth forming second (GO:0001702)2.20867060
174regulation of smoothened signaling pathway (GO:0008589)2.19755538

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.68383488
2RBPJ_22232070_ChIP-Seq_NCS_Mouse2.74425305
3TAF15_26573619_Chip-Seq_HEK293_Human2.69886054
4ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.67555853
5FUS_26573619_Chip-Seq_HEK293_Human2.48842311
6CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.45342756
7FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.31126386
8GBX2_23144817_ChIP-Seq_PC3_Human2.29709106
9FOXM1_23109430_ChIP-Seq_U2OS_Human2.21956191
10HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.21061337
11EZH2_27304074_Chip-Seq_ESCs_Mouse2.20739393
12JARID2_20064375_ChIP-Seq_MESCs_Mouse2.09028717
13EWS_26573619_Chip-Seq_HEK293_Human2.08972562
14EED_16625203_ChIP-ChIP_MESCs_Mouse2.05796734
15REST_21632747_ChIP-Seq_MESCs_Mouse2.04893941
16JARID2_20075857_ChIP-Seq_MESCs_Mouse2.02897031
17P300_19829295_ChIP-Seq_ESCs_Human2.02302299
18NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.02085109
19* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.97391546
20SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.95396196
21SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.95056581
22GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.91957113
23EZH2_18974828_ChIP-Seq_MESCs_Mouse1.91925576
24RNF2_18974828_ChIP-Seq_MESCs_Mouse1.91925576
25CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.88838718
26SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.87311630
27RNF2_27304074_Chip-Seq_ESCs_Mouse1.87004091
28EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.86558809
29EZH2_27294783_Chip-Seq_ESCs_Mouse1.83056361
30VDR_22108803_ChIP-Seq_LS180_Human1.82147815
31GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.78295126
32DROSHA_22980978_ChIP-Seq_HELA_Human1.75384769
33ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.74560206
34SUZ12_27294783_Chip-Seq_ESCs_Mouse1.72400512
35MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.70375070
36BMI1_23680149_ChIP-Seq_NPCS_Mouse1.69157319
37ZNF274_21170338_ChIP-Seq_K562_Hela1.68951951
38SALL1_21062744_ChIP-ChIP_HESCs_Human1.67033186
39AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.65503775
40REST_18959480_ChIP-ChIP_MESCs_Mouse1.63971753
41* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.63700834
42RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.59707207
43CBX2_27304074_Chip-Seq_ESCs_Mouse1.58653960
44TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.58551081
45SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.57549194
46RING1B_27294783_Chip-Seq_NPCs_Mouse1.57140109
47BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.53423578
48SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.52998103
49CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.52953085
50OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.52608112
51SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.48587041
52TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.48422668
53IGF1R_20145208_ChIP-Seq_DFB_Human1.48393812
54RING1B_27294783_Chip-Seq_ESCs_Mouse1.48126526
55RNF2_27304074_Chip-Seq_NSC_Mouse1.48112078
56SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.47995878
57CTBP2_25329375_ChIP-Seq_LNCAP_Human1.47368101
58SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.46810246
59SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.45724080
60SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.45423790
61PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.45411679
62RARB_27405468_Chip-Seq_BRAIN_Mouse1.45078634
63ZFP281_18757296_ChIP-ChIP_E14_Mouse1.44435656
64MTF2_20144788_ChIP-Seq_MESCs_Mouse1.40966804
65ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.39068691
66* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.38835410
67IRF1_19129219_ChIP-ChIP_H3396_Human1.38272455
68CTBP1_25329375_ChIP-Seq_LNCAP_Human1.32809776
69DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.32544175
70AR_21572438_ChIP-Seq_LNCaP_Human1.32500225
71ISL1_27105846_Chip-Seq_CPCs_Mouse1.31975766
72EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.31962131
73AR_19668381_ChIP-Seq_PC3_Human1.31369436
74SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.30741495
75SOX2_16153702_ChIP-ChIP_HESCs_Human1.29963252
76TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.29602465
77UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.28557268
78* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.27787573
79FLI1_27457419_Chip-Seq_LIVER_Mouse1.27192978
80* AR_25329375_ChIP-Seq_VCAP_Human1.26864975
81ZFP281_27345836_Chip-Seq_ESCs_Mouse1.24412613
82E2F4_17652178_ChIP-ChIP_JURKAT_Human1.23402197
83KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.23247492
84* SOX9_26525672_Chip-Seq_HEART_Mouse1.22858349
85TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.22794616
86STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.22431320
87E2F7_22180533_ChIP-Seq_HELA_Human1.22359780
88RUNX2_22187159_ChIP-Seq_PCA_Human1.21914563
89CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21265246
90TP63_19390658_ChIP-ChIP_HaCaT_Human1.18946865
91CBP_20019798_ChIP-Seq_JUKART_Human1.16693707
92IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.16693707
93NANOG_16153702_ChIP-ChIP_HESCs_Human1.16478573
94* PKCTHETA_26484144_Chip-Seq_BREAST_Human1.16255505
95PIAS1_25552417_ChIP-Seq_VCAP_Human1.15967537
96NANOG_18555785_Chip-Seq_ESCs_Mouse1.15745411
97STAT6_21828071_ChIP-Seq_BEAS2B_Human1.14213327
98WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.14053974
99MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.13078837
100POU5F1_16153702_ChIP-ChIP_HESCs_Human1.12942533
101E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.12890286
102PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.11688035
103RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.11414340
104SMAD4_21799915_ChIP-Seq_A2780_Human1.11194623
105TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11174774
106POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.11174774
107HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.10156610
108STAT3_23295773_ChIP-Seq_U87_Human1.09760011
109* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.09651712
110CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.09488994
111NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.09411890
112* TCF4_22108803_ChIP-Seq_LS180_Human1.09244603
113TCF4_23295773_ChIP-Seq_U87_Human1.09214007
114ZNF217_24962896_ChIP-Seq_MCF-7_Human1.08863636
115FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.08635250
116PCGF2_27294783_Chip-Seq_ESCs_Mouse1.08194274
117* SOX2_21211035_ChIP-Seq_LN229_Gbm1.07598141
118KLF5_20875108_ChIP-Seq_MESCs_Mouse1.07299930
119SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.06977585
120RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.05847607
121ARNT_22903824_ChIP-Seq_MCF-7_Human1.05575866
122SMAD3_21741376_ChIP-Seq_EPCs_Human1.05483432
123AHR_22903824_ChIP-Seq_MCF-7_Human1.04920996
124RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.04447221
125ER_23166858_ChIP-Seq_MCF-7_Human1.03933954
126MYC_18940864_ChIP-ChIP_HL60_Human1.03109652
127ERG_21242973_ChIP-ChIP_JURKAT_Human1.01969623
128TBX3_20139965_ChIP-Seq_MESCs_Mouse1.00752428
129P53_22127205_ChIP-Seq_FIBROBLAST_Human1.00686674
130TOP2B_26459242_ChIP-Seq_MCF-7_Human1.00390469
131* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.00020548
132PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.99502169
133TBX3_20139965_ChIP-Seq_ESCs_Mouse0.99278333
134* TAL1_26923725_Chip-Seq_HPCs_Mouse0.99148405
135BCAT_22108803_ChIP-Seq_LS180_Human0.98120076
136HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.97552451
137POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.97167770
138SOX2_18555785_ChIP-Seq_MESCs_Mouse0.96884735
139* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.96844441
140SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.95508025
141FOXM1_26456572_ChIP-Seq_MCF-7_Human0.95482933
142KDM2B_26808549_Chip-Seq_K562_Human0.94506722
143POU3F1_26484290_ChIP-Seq_ESCss_Mouse0.94450061
144TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.94417149
145* SMAD4_21741376_ChIP-Seq_HESCs_Human0.94344235
146NR3C1_21868756_ChIP-Seq_MCF10A_Human0.94334262
147POU3F2_20337985_ChIP-ChIP_501MEL_Human0.93949846
148FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.93753414
149LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92683219
150EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.92311107
151CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.91823360
152TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.91720652
153GATA1_26923725_Chip-Seq_HPCs_Mouse0.90088990

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006072_abnormal_retinal_apoptosis3.13904769
2MP0003283_abnormal_digestive_organ3.09597372
3MP0005551_abnormal_eye_electrophysiolog2.86180004
4MP0003136_yellow_coat_color2.72852006
5MP0000569_abnormal_digit_pigmentation2.59533283
6MP0003122_maternal_imprinting2.59047347
7MP0004859_abnormal_synaptic_plasticity2.58674884
8MP0005253_abnormal_eye_physiology2.56923622
9MP0002653_abnormal_ependyma_morphology2.53912824
10MP0002638_abnormal_pupillary_reflex2.46364356
11MP0003011_delayed_dark_adaptation2.36194954
12MP0000537_abnormal_urethra_morphology2.33780615
13MP0010030_abnormal_orbit_morphology2.12775544
14MP0003121_genomic_imprinting2.10565986
15MP0000778_abnormal_nervous_system2.09748424
16MP0003890_abnormal_embryonic-extraembry2.08804948
17MP0001529_abnormal_vocalization2.05176485
18MP0003123_paternal_imprinting2.01047045
19MP0010386_abnormal_urinary_bladder2.00648113
20MP0000566_synostosis1.98042730
21MP0003119_abnormal_digestive_system1.77345708
22MP0005377_hearing/vestibular/ear_phenot1.77184789
23MP0003878_abnormal_ear_physiology1.77184789
24MP0009780_abnormal_chondrocyte_physiolo1.74939924
25MP0003787_abnormal_imprinting1.74938958
26MP0006276_abnormal_autonomic_nervous1.73416648
27MP0005499_abnormal_olfactory_system1.73402097
28MP0005394_taste/olfaction_phenotype1.73402097
29MP0008877_abnormal_DNA_methylation1.72898588
30MP0004270_analgesia1.68987785
31MP0008789_abnormal_olfactory_epithelium1.64273962
32MP0003635_abnormal_synaptic_transmissio1.63349007
33MP0005391_vision/eye_phenotype1.62347203
34MP0008961_abnormal_basal_metabolism1.59495805
35MP0002234_abnormal_pharynx_morphology1.57642341
36MP0005423_abnormal_somatic_nervous1.56843860
37MP0001486_abnormal_startle_reflex1.53465733
38MP0005195_abnormal_posterior_eye1.50030838
39MP0006292_abnormal_olfactory_placode1.49468649
40MP0000631_abnormal_neuroendocrine_gland1.49307011
41MP0005187_abnormal_penis_morphology1.48493729
42MP0005248_abnormal_Harderian_gland1.48358385
43MP0004133_heterotaxia1.47884825
44MP0001346_abnormal_lacrimal_gland1.45119922
45MP0002063_abnormal_learning/memory/cond1.42204968
46MP0002184_abnormal_innervation1.41802155
47MP0002882_abnormal_neuron_morphology1.37288272
48MP0003861_abnormal_nervous_system1.33166168
49MP0002752_abnormal_somatic_nervous1.29942076
50MP0002282_abnormal_trachea_morphology1.29641766
51MP0002909_abnormal_adrenal_gland1.28716341
52MP0003880_abnormal_central_pattern1.28038810
53MP0002557_abnormal_social/conspecific_i1.24827336
54MP0001485_abnormal_pinna_reflex1.23765631
55MP0002734_abnormal_mechanical_nocicepti1.23468963
56MP0002938_white_spotting1.23112039
57MP0004233_abnormal_muscle_weight1.21973778
58MP0001324_abnormal_eye_pigmentation1.21790703
59MP0001299_abnormal_eye_distance/1.21053861
60MP0000462_abnormal_digestive_system1.20993857
61MP0000383_abnormal_hair_follicle1.20726787
62MP0000955_abnormal_spinal_cord1.19611408
63MP0001293_anophthalmia1.19070466
64MP0002152_abnormal_brain_morphology1.17903430
65MP0002064_seizures1.15924130
66MP0003115_abnormal_respiratory_system1.15466637
67MP0000026_abnormal_inner_ear1.14083967
68MP0002572_abnormal_emotion/affect_behav1.13708532
69MP0000579_abnormal_nail_morphology1.11227764
70MP0001286_abnormal_eye_development1.08844699
71MP0002697_abnormal_eye_size1.08486322
72MP0004811_abnormal_neuron_physiology1.05942065
73MP0003755_abnormal_palate_morphology1.05294093
74MP0004147_increased_porphyrin_level1.05078615
75MP0002067_abnormal_sensory_capabilities1.04936919
76MP0002272_abnormal_nervous_system1.02800826
77MP0001502_abnormal_circadian_rhythm1.02165384
78MP0009745_abnormal_behavioral_response1.01318147
79MP0000647_abnormal_sebaceous_gland1.01025150
80MP0002249_abnormal_larynx_morphology1.00324331
81MP0002229_neurodegeneration0.99923988
82MP0001984_abnormal_olfaction0.97873593
83MP0002822_catalepsy0.97597195
84MP0002736_abnormal_nociception_after0.97496994
85MP0000049_abnormal_middle_ear0.96319528
86MP0002102_abnormal_ear_morphology0.96190095
87MP0009046_muscle_twitch0.96034027
88MP0009703_decreased_birth_body0.95786781
89MP0005646_abnormal_pituitary_gland0.95320478
90MP0008932_abnormal_embryonic_tissue0.95080900
91MP0001944_abnormal_pancreas_morphology0.94888410
92MP0005386_behavior/neurological_phenoty0.94559331
93MP0004924_abnormal_behavior0.94559331
94MP0003137_abnormal_impulse_conducting0.93972506
95MP0002177_abnormal_outer_ear0.93834921
96MP0002751_abnormal_autonomic_nervous0.93351927
97MP0005076_abnormal_cell_differentiation0.93191929
98MP0003938_abnormal_ear_development0.93139190
99MP0000428_abnormal_craniofacial_morphol0.92783306
100MP0001963_abnormal_hearing_physiology0.92570740
101MP0010678_abnormal_skin_adnexa0.92378436
102MP0003942_abnormal_urinary_system0.91228781
103MP0004885_abnormal_endolymph0.91127113
104MP0002233_abnormal_nose_morphology0.90619201
105MP0001188_hyperpigmentation0.89343540
106MP0002084_abnormal_developmental_patter0.88379231
107MP0010234_abnormal_vibrissa_follicle0.87833677
108MP0005645_abnormal_hypothalamus_physiol0.87586067
109MP0003879_abnormal_hair_cell0.86658035
110MP0003937_abnormal_limbs/digits/tail_de0.86316915
111MP0002735_abnormal_chemical_nociception0.86179846
112MP0000678_abnormal_parathyroid_gland0.86115215
113MP0003698_abnormal_male_reproductive0.83721667
114MP0004742_abnormal_vestibular_system0.82510638
115MP0002111_abnormal_tail_morphology0.82388562
116MP0002085_abnormal_embryonic_tissue0.80641167
117MP0001177_atelectasis0.79628036
118MP0002092_abnormal_eye_morphology0.77981799
119MP0008058_abnormal_DNA_repair0.77971245
120MP0010094_abnormal_chromosome_stability0.77453426
121MP0002090_abnormal_vision0.77213522
122MP0009053_abnormal_anal_canal0.76830489
123MP0009672_abnormal_birth_weight0.76800822
124MP0001968_abnormal_touch/_nociception0.76521738
125MP0003935_abnormal_craniofacial_develop0.76046755
126MP0002116_abnormal_craniofacial_bone0.76017083
127MP0008569_lethality_at_weaning0.75083348
128MP0002081_perinatal_lethality0.74294150

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)5.70059195
2Congenital stationary night blindness (HP:0007642)5.15001127
3Abnormal respiratory motile cilium morphology (HP:0005938)5.08260842
4Abnormal respiratory epithelium morphology (HP:0012253)5.08260842
5Abnormal ciliary motility (HP:0012262)5.07776732
6Abnormal respiratory motile cilium physiology (HP:0012261)5.04224235
7Bony spicule pigmentary retinopathy (HP:0007737)4.97189144
8Absent/shortened dynein arms (HP:0200106)4.67546146
9Dynein arm defect of respiratory motile cilia (HP:0012255)4.67546146
10Rhinitis (HP:0012384)4.65330012
11Central scotoma (HP:0000603)4.26706353
12Abnormal rod and cone electroretinograms (HP:0008323)4.11454406
13Pendular nystagmus (HP:0012043)3.99390605
14Absent rod-and cone-mediated responses on ERG (HP:0007688)3.98721719
15Chorioretinal atrophy (HP:0000533)3.87673866
16Abnormality of macular pigmentation (HP:0008002)3.84803807
17Decreased central vision (HP:0007663)3.57580885
18Chronic bronchitis (HP:0004469)3.55683006
19Scotoma (HP:0000575)3.40119495
20Medial flaring of the eyebrow (HP:0010747)3.09623645
21Nephronophthisis (HP:0000090)3.09076202
22Type II diabetes mellitus (HP:0005978)3.06600976
23Bronchiectasis (HP:0002110)2.85794463
24Abolished electroretinogram (ERG) (HP:0000550)2.84519612
25Attenuation of retinal blood vessels (HP:0007843)2.80698080
26Occipital encephalocele (HP:0002085)2.80205780
27Postaxial foot polydactyly (HP:0001830)2.79002606
28Nephrogenic diabetes insipidus (HP:0009806)2.77531470
29Visual hallucinations (HP:0002367)2.74882488
30Cone-rod dystrophy (HP:0000548)2.71969728
31Renal duplication (HP:0000075)2.66420671
32Chronic hepatic failure (HP:0100626)2.66115021
33Severe visual impairment (HP:0001141)2.59352954
34Dyschromatopsia (HP:0007641)2.57706201
35Posterior subcapsular cataract (HP:0007787)2.54153010
36Elfin facies (HP:0004428)2.53280749
37Anencephaly (HP:0002323)2.52756259
38Postaxial hand polydactyly (HP:0001162)2.49743342
39Focal motor seizures (HP:0011153)2.49645153
40Pigmentary retinal degeneration (HP:0001146)2.49484422
41Congenital sensorineural hearing impairment (HP:0008527)2.45561776
42Aplasia/Hypoplasia of the tongue (HP:0010295)2.43678768
43Hyperacusis (HP:0010780)2.43536003
44Poor coordination (HP:0002370)2.42987925
45Abnormality of the renal medulla (HP:0100957)2.42265559
46Anophthalmia (HP:0000528)2.38055345
47Broad foot (HP:0001769)2.34585188
48Intestinal atresia (HP:0011100)2.32156779
49Volvulus (HP:0002580)2.28680913
50Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.27169937
51Insomnia (HP:0100785)2.25683287
52True hermaphroditism (HP:0010459)2.23543821
53Focal seizures (HP:0007359)2.20318970
54Supernumerary spleens (HP:0009799)2.18044308
55Increased corneal curvature (HP:0100692)2.15480240
56Keratoconus (HP:0000563)2.15480240
57Abnormality of the astrocytes (HP:0100707)2.13845498
58Astrocytoma (HP:0009592)2.13845498
59Renovascular hypertension (HP:0100817)2.11573307
60Optic nerve hypoplasia (HP:0000609)2.11125447
61Absence seizures (HP:0002121)2.10378146
62Cortical dysplasia (HP:0002539)2.10316411
63Photophobia (HP:0000613)2.09459928
64Labial hypoplasia (HP:0000066)2.07629992
65Overriding aorta (HP:0002623)2.06589655
66Esophageal atresia (HP:0002032)2.05451992
67Aqueductal stenosis (HP:0002410)2.05035249
68Vitreoretinal degeneration (HP:0000655)2.04159980
69Increased nuchal translucency (HP:0010880)2.03546612
70Gastrointestinal atresia (HP:0002589)2.02472745
71High anterior hairline (HP:0009890)2.01797762
72Abnormality of the labia minora (HP:0012880)2.01354190
73Hyperglycinemia (HP:0002154)1.96939876
74Macroorchidism (HP:0000053)1.95670310
75Ependymoma (HP:0002888)1.94390410
76Retinitis pigmentosa (HP:0000510)1.92661306
77Short 4th metacarpal (HP:0010044)1.92392277
78Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.92392277
79Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.92071342
80Hepatoblastoma (HP:0002884)1.90522543
81Congenital hepatic fibrosis (HP:0002612)1.90469253
82Macular degeneration (HP:0000608)1.90271841
83Holoprosencephaly (HP:0001360)1.90081270
84Cystic liver disease (HP:0006706)1.89913386
85Male pseudohermaphroditism (HP:0000037)1.86897312
86Decreased testicular size (HP:0008734)1.86210017
87Specific learning disability (HP:0001328)1.85536276
88Bilateral microphthalmos (HP:0007633)1.85533414
89Abnormal lung lobation (HP:0002101)1.84355925
90Papillary thyroid carcinoma (HP:0002895)1.83850325
91Gait imbalance (HP:0002141)1.83732161
92Absent septum pellucidum (HP:0001331)1.83564188
93Renal hypoplasia (HP:0000089)1.82514312
94Median cleft lip (HP:0000161)1.81736232
95Oligodactyly (HP:0012165)1.81478628
96Protruding tongue (HP:0010808)1.81157326
97Pancreatic fibrosis (HP:0100732)1.81079504
98Hypoplastic female external genitalia (HP:0012815)1.80985791
99Febrile seizures (HP:0002373)1.80786785
100Congenital primary aphakia (HP:0007707)1.80637491
101Abnormality of the diencephalon (HP:0010662)1.79888097
102Anal stenosis (HP:0002025)1.79310011
103Glioma (HP:0009733)1.78882531
104Epileptic encephalopathy (HP:0200134)1.78827164
105Obsessive-compulsive behavior (HP:0000722)1.76934827
106Narrow forehead (HP:0000341)1.75909491
107Constricted visual fields (HP:0001133)1.75436213
108Cutaneous finger syndactyly (HP:0010554)1.75060962
109Micropenis (HP:0000054)1.74924208
110Chorioretinal coloboma (HP:0000567)1.74177716
111Hemivertebrae (HP:0002937)1.74072539
112Bifid scrotum (HP:0000048)1.73873167
113Abnormal pancreas size (HP:0012094)1.73261325
114Abnormal number of incisors (HP:0011064)1.71658799
115EEG with generalized epileptiform discharges (HP:0011198)1.70344903
116Bile duct proliferation (HP:0001408)1.70018527
117Abnormal biliary tract physiology (HP:0012439)1.70018527
118Bicornuate uterus (HP:0000813)1.68502936
119Progressive cerebellar ataxia (HP:0002073)1.68111013
120Bifid tongue (HP:0010297)1.67332091
121Multicystic kidney dysplasia (HP:0000003)1.67078678
122Hypsarrhythmia (HP:0002521)1.67069017
123Tubular atrophy (HP:0000092)1.65119715
124Dandy-Walker malformation (HP:0001305)1.64431699
125Sclerocornea (HP:0000647)1.64268996
126Infertility (HP:0000789)1.64136704
127Nasal polyposis (HP:0100582)1.64002600
128Pancreatic cysts (HP:0001737)1.63702869
129Broad distal phalanx of finger (HP:0009836)1.63663375
130Oculomotor apraxia (HP:0000657)1.63385944
131Ankyloglossia (HP:0010296)1.63337444
132Epileptiform EEG discharges (HP:0011182)1.62619203
133Cutaneous syndactyly (HP:0012725)1.61827169
134Abnormality of the septum pellucidum (HP:0007375)1.61723138
135Pointed chin (HP:0000307)1.61709018
136Molar tooth sign on MRI (HP:0002419)1.61295680
137Abnormality of midbrain morphology (HP:0002418)1.61295680
138Medulloblastoma (HP:0002885)1.60616106
139Dialeptic seizures (HP:0011146)1.59924360
140Hypoplastic labia majora (HP:0000059)1.59803587
141Drooling (HP:0002307)1.59359171
142Excessive salivation (HP:0003781)1.59359171
143Vaginal atresia (HP:0000148)1.58936883
144Colon cancer (HP:0003003)1.58647877
145Renal dysplasia (HP:0000110)1.57877533
146Ventricular fibrillation (HP:0001663)1.57792788
147Abdominal situs inversus (HP:0003363)1.57135190
148Abnormality of abdominal situs (HP:0011620)1.57135190
149Aganglionic megacolon (HP:0002251)1.55795739
150Myokymia (HP:0002411)1.54735647
151Septo-optic dysplasia (HP:0100842)1.54606118
152Oligodactyly (hands) (HP:0001180)1.54343975
153Aplasia/Hypoplasia of the sternum (HP:0006714)1.53972877
154Genital tract atresia (HP:0001827)1.53449018
155Exotropia (HP:0000577)1.52068669
156Abnormality of the 4th metacarpal (HP:0010012)1.51965541
157Tubulointerstitial nephritis (HP:0001970)1.51664571
158Omphalocele (HP:0001539)1.51033730
159Growth hormone deficiency (HP:0000824)1.50325911
160Prominent nasal bridge (HP:0000426)1.49698583
161Abnormality of the aortic arch (HP:0012303)1.49500472
162Subcapsular cataract (HP:0000523)1.49067807
163Preaxial hand polydactyly (HP:0001177)1.48953329
164Progressive sensorineural hearing impairment (HP:0000408)1.48623451
165Midline defect of the nose (HP:0004122)1.48507798
166Preaxial foot polydactyly (HP:0001841)1.48489661

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK3.13883104
2ERBB33.06002583
3MAP3K92.70824664
4TNIK2.64241151
5MAP4K22.63796417
6MAPK152.61452893
7KSR12.58047618
8MARK12.54303564
9TRIM282.51400209
10PASK2.29992338
11NTRK32.17988643
12MAP3K42.16548639
13INSRR2.11356420
14UHMK12.05340669
15BCR1.99013205
16CDK191.97094357
17NTRK21.83360048
18BRSK11.79353499
19CDC71.78887435
20EPHB21.74959872
21BMPR1B1.73906114
22BRSK21.72908410
23EPHA31.71116552
24WEE11.62149887
25LMTK21.62140989
26MINK11.61790857
27ERBB21.53860287
28FGFR21.53012957
29PNCK1.50940918
30WNK31.50681363
31MAP3K101.48625404
32TSSK61.46175121
33SIK31.43321290
34NEK11.42649707
35TLK11.37133369
36STK38L1.35080412
37FRK1.30044149
38FER1.28679077
39PAK61.27770926
40CSNK1G11.26742657
41VRK11.26588225
42MKNK11.26324924
43MAP2K71.26189846
44BUB11.25634080
45PLK31.25351003
46CDC42BPA1.22619868
47SIK11.19380513
48ACVR1B1.15658037
49CSNK1G31.15431829
50CCNB11.14757279
51VRK21.14006748
52NUAK11.12792368
53PLK21.11649600
54PRKD31.11418281
55MST41.10105467
56GRK11.06566739
57PAK31.05485908
58OXSR11.03759215
59SCYL21.00394425
60LATS10.99652504
61FGFR10.96776778
62TAF10.96717643
63BRD40.94401404
64DYRK1B0.93335966
65PDGFRA0.92238639
66ZAK0.91603457
67STK380.91460283
68SIK20.90523199
69TTK0.88997607
70ICK0.88669443
71HIPK20.88289706
72RPS6KA40.88220822
73PLK40.88026361
74CAMK1G0.87997808
75MAP3K120.87680928
76SRPK10.87140638
77MAP3K20.86836038
78CDK50.86321196
79AURKA0.85626800
80NEK20.85026938
81TYRO30.84440884
82PLK10.82964494
83DYRK1A0.82614729
84SGK4940.81828764
85SGK2230.81828764
86CHEK20.79975719
87DYRK20.79687572
88CDK180.78703130
89MKNK20.77799747
90NLK0.76764778
91STK30.73635209
92ATR0.72621707
93DYRK30.71702121
94CAMKK10.70639937
95DDR20.70269714
96MELK0.68743298
97CDK150.68645775
98CSNK1E0.68540400
99CDK120.67650314
100MAP2K40.66999893
101PTK60.65668883
102CAMK1D0.64485358
103CDK10.64142527
104ALK0.63501563
105CDK140.63171922
106STK390.60537365
107IRAK20.60417207
108TGFBR10.60274237
109CDK11A0.59825778
110CDK30.59205103
111MAPK90.58507381
112PBK0.58372176
113ADRBK20.57275362
114CSNK1A1L0.57113330
115CHEK10.57050769
116MAPK130.56651479
117PRKDC0.56552198
118AURKB0.56550264
119AKT20.56549729
120CSNK1G20.56464120
121BCKDK0.55516549
122PRKCE0.55330833
123CDK20.55034994
124MAPK100.53061123
125PRKCG0.52767555
126CSNK1D0.51772733
127PINK10.51645760
128PAK40.50942998
129PRKCZ0.50590125
130EPHA40.50112772
131STK110.49060398
132ATM0.48891027
133YES10.47387856
134GSK3B0.47064485
135CSNK1A10.45640529
136STK160.43704326
137NME10.39375263
138CAMK2A0.36895622
139WNK40.36468457

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047445.44995524
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.53777841
3Maturity onset diabetes of the young_Homo sapiens_hsa049503.02422799
4Nicotine addiction_Homo sapiens_hsa050332.72572793
5Steroid biosynthesis_Homo sapiens_hsa001002.71393369
6Synaptic vesicle cycle_Homo sapiens_hsa047212.31211142
7GABAergic synapse_Homo sapiens_hsa047272.24449019
8Insulin secretion_Homo sapiens_hsa049112.19798974
9Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.01856206
10Propanoate metabolism_Homo sapiens_hsa006401.94710933
11Basal cell carcinoma_Homo sapiens_hsa052171.87059814
12Non-homologous end-joining_Homo sapiens_hsa034501.80489069
13Circadian entrainment_Homo sapiens_hsa047131.71507243
14Dopaminergic synapse_Homo sapiens_hsa047281.70814186
15Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.70394968
16Protein export_Homo sapiens_hsa030601.70308813
17Fanconi anemia pathway_Homo sapiens_hsa034601.68945718
18Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.67472608
19Hippo signaling pathway_Homo sapiens_hsa043901.65807778
20Mismatch repair_Homo sapiens_hsa034301.64983907
21Oocyte meiosis_Homo sapiens_hsa041141.58113499
22Long-term potentiation_Homo sapiens_hsa047201.57424292
23Morphine addiction_Homo sapiens_hsa050321.57102852
24Olfactory transduction_Homo sapiens_hsa047401.55799883
25Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.55580359
26Butanoate metabolism_Homo sapiens_hsa006501.54865389
27Huntingtons disease_Homo sapiens_hsa050161.53127491
28Cholinergic synapse_Homo sapiens_hsa047251.52525709
29Glutamatergic synapse_Homo sapiens_hsa047241.52183018
30Alcoholism_Homo sapiens_hsa050341.50995086
31Type II diabetes mellitus_Homo sapiens_hsa049301.50774682
32Amphetamine addiction_Homo sapiens_hsa050311.48231689
33Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.45406125
34Vibrio cholerae infection_Homo sapiens_hsa051101.41848893
35Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.41402072
36Taste transduction_Homo sapiens_hsa047421.38792900
37Wnt signaling pathway_Homo sapiens_hsa043101.38319298
38Melanogenesis_Homo sapiens_hsa049161.37627734
39Cocaine addiction_Homo sapiens_hsa050301.37208544
40mRNA surveillance pathway_Homo sapiens_hsa030151.37170486
41Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.31142348
42Notch signaling pathway_Homo sapiens_hsa043301.30724348
43Hedgehog signaling pathway_Homo sapiens_hsa043401.30148354
44Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.21414804
45Axon guidance_Homo sapiens_hsa043601.21292183
46Gap junction_Homo sapiens_hsa045401.21102590
47Vitamin B6 metabolism_Homo sapiens_hsa007501.19873668
48Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.19549226
49Homologous recombination_Homo sapiens_hsa034401.15684450
50Gastric acid secretion_Homo sapiens_hsa049711.13818329
51Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.13687489
52Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.13638461
53Basal transcription factors_Homo sapiens_hsa030221.13233183
54Serotonergic synapse_Homo sapiens_hsa047261.12965336
55mTOR signaling pathway_Homo sapiens_hsa041501.12527777
56Carbohydrate digestion and absorption_Homo sapiens_hsa049731.12401988
57Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.12153978
58Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.12112416
59Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.09401170
60Endometrial cancer_Homo sapiens_hsa052131.08158979
61Aldosterone synthesis and secretion_Homo sapiens_hsa049251.08010521
62Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.07623297
63Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.07389498
64Salivary secretion_Homo sapiens_hsa049701.04177147
65Circadian rhythm_Homo sapiens_hsa047101.02764581
66beta-Alanine metabolism_Homo sapiens_hsa004101.01630660
67Base excision repair_Homo sapiens_hsa034101.00006259
68Estrogen signaling pathway_Homo sapiens_hsa049150.99605980
69Cysteine and methionine metabolism_Homo sapiens_hsa002700.98611336
70Colorectal cancer_Homo sapiens_hsa052100.98181019
71Thyroid hormone synthesis_Homo sapiens_hsa049180.97935609
72Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.97062420
73Spliceosome_Homo sapiens_hsa030400.96723440
74Oxidative phosphorylation_Homo sapiens_hsa001900.94657326
75Glioma_Homo sapiens_hsa052140.93309104
76Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.92720981
77Tight junction_Homo sapiens_hsa045300.90525600
78Fatty acid elongation_Homo sapiens_hsa000620.90009322
79Nucleotide excision repair_Homo sapiens_hsa034200.89867277
80Cell cycle_Homo sapiens_hsa041100.89358204
81Nitrogen metabolism_Homo sapiens_hsa009100.88659950
82Glutathione metabolism_Homo sapiens_hsa004800.88279052
83Thyroid hormone signaling pathway_Homo sapiens_hsa049190.88261774
84Chemical carcinogenesis_Homo sapiens_hsa052040.87913504
85ErbB signaling pathway_Homo sapiens_hsa040120.87295281
86N-Glycan biosynthesis_Homo sapiens_hsa005100.86662419
87Adherens junction_Homo sapiens_hsa045200.86544604
88Long-term depression_Homo sapiens_hsa047300.85674497
89Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.85586519
90Peroxisome_Homo sapiens_hsa041460.85402469
91Linoleic acid metabolism_Homo sapiens_hsa005910.85388891
92RNA degradation_Homo sapiens_hsa030180.83741936
93Pancreatic secretion_Homo sapiens_hsa049720.82960699
94Parkinsons disease_Homo sapiens_hsa050120.82883702
95Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.81865607
96Histidine metabolism_Homo sapiens_hsa003400.81748104
97Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.81142963
98Phosphatidylinositol signaling system_Homo sapiens_hsa040700.80715286
99GnRH signaling pathway_Homo sapiens_hsa049120.79768178
100DNA replication_Homo sapiens_hsa030300.78220812
101Oxytocin signaling pathway_Homo sapiens_hsa049210.77947003
102Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.77871554
103Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.77664441
104Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.75287375
105cAMP signaling pathway_Homo sapiens_hsa040240.74764116
106RNA polymerase_Homo sapiens_hsa030200.74601418
107Arginine and proline metabolism_Homo sapiens_hsa003300.74122331
108Fatty acid metabolism_Homo sapiens_hsa012120.73375066
109Renin secretion_Homo sapiens_hsa049240.73140919
110Retinol metabolism_Homo sapiens_hsa008300.71909359
111cGMP-PKG signaling pathway_Homo sapiens_hsa040220.70093428
112Renal cell carcinoma_Homo sapiens_hsa052110.69376999
113Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.68912736
114MicroRNAs in cancer_Homo sapiens_hsa052060.68692648
115Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.68435438
116alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.67730074
117Glucagon signaling pathway_Homo sapiens_hsa049220.67142166
118Systemic lupus erythematosus_Homo sapiens_hsa053220.65592223
119Type I diabetes mellitus_Homo sapiens_hsa049400.65320239
120Tyrosine metabolism_Homo sapiens_hsa003500.65134804
121Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.64863257
122Ether lipid metabolism_Homo sapiens_hsa005650.64202635
123Lysine degradation_Homo sapiens_hsa003100.63887949
124Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.62727513
125Primary bile acid biosynthesis_Homo sapiens_hsa001200.61572265
126Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.60567700
127Dorso-ventral axis formation_Homo sapiens_hsa043200.60523648
128Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.59628387
129Selenocompound metabolism_Homo sapiens_hsa004500.58198426
130Fat digestion and absorption_Homo sapiens_hsa049750.57618236
131RNA transport_Homo sapiens_hsa030130.57617767
132Purine metabolism_Homo sapiens_hsa002300.54921313
133Pentose and glucuronate interconversions_Homo sapiens_hsa000400.54690248
134Biosynthesis of amino acids_Homo sapiens_hsa012300.54363614
135Neurotrophin signaling pathway_Homo sapiens_hsa047220.53881113
136Phenylalanine metabolism_Homo sapiens_hsa003600.53487943
137Tryptophan metabolism_Homo sapiens_hsa003800.53169949
138Pyruvate metabolism_Homo sapiens_hsa006200.52439983
139Central carbon metabolism in cancer_Homo sapiens_hsa052300.52177335
140Choline metabolism in cancer_Homo sapiens_hsa052310.51037119
141Non-small cell lung cancer_Homo sapiens_hsa052230.49830021
142Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.49751849
143AMPK signaling pathway_Homo sapiens_hsa041520.49555016
144Proteoglycans in cancer_Homo sapiens_hsa052050.47846503
145Insulin signaling pathway_Homo sapiens_hsa049100.47743083
146Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.47655134
147Longevity regulating pathway - mammal_Homo sapiens_hsa042110.46218255
148Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.45854460
149Collecting duct acid secretion_Homo sapiens_hsa049660.45383428
150MAPK signaling pathway_Homo sapiens_hsa040100.43747882
151TGF-beta signaling pathway_Homo sapiens_hsa043500.42377033
152Chronic myeloid leukemia_Homo sapiens_hsa052200.41710539
153Dilated cardiomyopathy_Homo sapiens_hsa054140.35911342
154Pathways in cancer_Homo sapiens_hsa052000.35710918
155Sulfur metabolism_Homo sapiens_hsa009200.35429050
156Cardiac muscle contraction_Homo sapiens_hsa042600.34532553
157Calcium signaling pathway_Homo sapiens_hsa040200.34072921

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