PLCH2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: PLCH2 is a member of the PLC-eta family of the phosphoinositide-specific phospholipase C (PLC) superfamily of enzymes that cleave PtdIns(4,5) P2 to generate second messengers inositol 1,4,5-trisphosphate and diacylglycerol (Zhou et al., 2005 [PubMed 16107206]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1hemidesmosome assembly (GO:0031581)8.52189749
2regulation of short-term neuronal synaptic plasticity (GO:0048172)6.17305321
3positive regulation of calcium ion-dependent exocytosis (GO:0045956)6.05428525
4desmosome organization (GO:0002934)6.00311471
5synaptic vesicle maturation (GO:0016188)5.98898123
6locomotory exploration behavior (GO:0035641)5.94423223
7positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.81513538
8cellular potassium ion homeostasis (GO:0030007)5.39470786
9vocalization behavior (GO:0071625)5.24913783
10synaptic vesicle exocytosis (GO:0016079)5.07275534
11glutamate secretion (GO:0014047)5.01757155
12sodium ion export (GO:0071436)4.98847602
13response to pheromone (GO:0019236)4.97160741
14synaptic vesicle docking involved in exocytosis (GO:0016081)4.86606727
15regulation of synaptic vesicle exocytosis (GO:2000300)4.86005354
16regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.77546534
17ionotropic glutamate receptor signaling pathway (GO:0035235)4.73628824
18neuronal action potential propagation (GO:0019227)4.71411924
19protein localization to synapse (GO:0035418)4.66876274
20establishment of skin barrier (GO:0061436)4.63838319
21neurotransmitter secretion (GO:0007269)4.46712538
22synaptic transmission, glutamatergic (GO:0035249)4.46170397
23glutamate receptor signaling pathway (GO:0007215)4.45315970
24cerebellar granule cell differentiation (GO:0021707)4.36321137
25layer formation in cerebral cortex (GO:0021819)4.34663137
26positive regulation of synapse maturation (GO:0090129)4.32590955
27cerebellar Purkinje cell differentiation (GO:0021702)4.31709566
28regulation of glutamate receptor signaling pathway (GO:1900449)4.29235341
29regulation of synaptic vesicle transport (GO:1902803)4.26105633
30G-protein coupled glutamate receptor signaling pathway (GO:0007216)4.26024858
31gamma-aminobutyric acid transport (GO:0015812)4.23700304
32exploration behavior (GO:0035640)4.15916846
33regulation of water loss via skin (GO:0033561)4.13951348
34long-term memory (GO:0007616)4.13447774
35regulation of inhibitory postsynaptic membrane potential (GO:0060080)4.07342146
36dendritic spine morphogenesis (GO:0060997)4.04306578
37neuron-neuron synaptic transmission (GO:0007270)4.02521668
38neurotransmitter-gated ion channel clustering (GO:0072578)3.97747714
39regulation of long-term neuronal synaptic plasticity (GO:0048169)3.92057363
40regulation of neuronal synaptic plasticity (GO:0048168)3.90512346
41cell-substrate junction assembly (GO:0007044)3.87433319
42positive regulation of membrane potential (GO:0045838)3.85463318
43potassium ion homeostasis (GO:0055075)3.82951898
44peptidyl-tyrosine autophosphorylation (GO:0038083)3.81589040
45regulation of excitatory postsynaptic membrane potential (GO:0060079)3.73618140
46cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.72477604
47regulation of clathrin-mediated endocytosis (GO:2000369)3.70884888
48neuromuscular process controlling posture (GO:0050884)3.69336494
49neurotransmitter transport (GO:0006836)3.66918646
50keratinocyte proliferation (GO:0043616)3.66802167
51signal complex assembly (GO:0007172)3.63209508
52regulation of postsynaptic membrane potential (GO:0060078)3.61017266
53gamma-aminobutyric acid signaling pathway (GO:0007214)3.58763871
54positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.55262691
55rhodopsin mediated signaling pathway (GO:0016056)3.54080347
56potassium ion import (GO:0010107)3.52468072
57synaptic vesicle endocytosis (GO:0048488)3.52254375
58neuromuscular process controlling balance (GO:0050885)3.48877067
59membrane hyperpolarization (GO:0060081)3.47869725
60membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.47792818
61regulation of voltage-gated calcium channel activity (GO:1901385)3.45694524
62regulation of rhodopsin mediated signaling pathway (GO:0022400)3.43526572
63regulation of neurotransmitter secretion (GO:0046928)3.43007192
64cell differentiation in hindbrain (GO:0021533)3.42479062
65cell communication by electrical coupling (GO:0010644)3.38120062
66regulation of synapse structural plasticity (GO:0051823)3.37074509
67regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.37063427
68chemosensory behavior (GO:0007635)3.36266512
69cellular sodium ion homeostasis (GO:0006883)3.29882999
70regulation of vesicle fusion (GO:0031338)3.29413857
71regulation of neurotransmitter levels (GO:0001505)3.24274406
72neuron cell-cell adhesion (GO:0007158)3.24107014
73transmission of nerve impulse (GO:0019226)3.22993669
74regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.22102016
75regulation of ARF GTPase activity (GO:0032312)3.21653067
76long term synaptic depression (GO:0060292)3.20826286
77regulation of synapse maturation (GO:0090128)3.20512970
78long-term synaptic potentiation (GO:0060291)3.20158526
79regulation of ARF protein signal transduction (GO:0032012)3.18201106
80regulation of synaptic plasticity (GO:0048167)3.17426866
81negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.16209071
82innervation (GO:0060384)3.16032156
83positive regulation of Rap GTPase activity (GO:0032854)3.15386606
84activation of protein kinase A activity (GO:0034199)3.14744024
85membrane depolarization during action potential (GO:0086010)3.11795537
86positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.11195782
87amino acid import (GO:0043090)3.10920368
88membrane depolarization (GO:0051899)3.10644873
89L-amino acid import (GO:0043092)3.09659973
90glycine transport (GO:0015816)3.09387546
91dendrite morphogenesis (GO:0048813)3.09329137
92regulation of neurotransmitter transport (GO:0051588)3.09065468
93retinal cone cell development (GO:0046549)3.08527618
94regulation of dendritic spine morphogenesis (GO:0061001)3.07104086
95central nervous system myelination (GO:0022010)3.06445466
96axon ensheathment in central nervous system (GO:0032291)3.06445466
97dendritic spine organization (GO:0097061)3.05540195
98multicellular organismal water homeostasis (GO:0050891)3.03003376
99proline transport (GO:0015824)3.00860680
100positive regulation of vesicle fusion (GO:0031340)3.00232105
101regulation of synaptic transmission, glutamatergic (GO:0051966)2.98598927
102keratinization (GO:0031424)2.96362053
103mating behavior (GO:0007617)2.95951593
104intermediate filament organization (GO:0045109)2.95540436
105semaphorin-plexin signaling pathway (GO:0071526)2.93310402
106positive regulation of dendritic spine morphogenesis (GO:0061003)2.93064294
107auditory behavior (GO:0031223)2.91973702
108neuronal ion channel clustering (GO:0045161)2.91917915
109negative regulation of synaptic transmission, GABAergic (GO:0032229)2.91410526
110positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.91179478
111regulation of calcium ion-dependent exocytosis (GO:0017158)2.91051469
112positive regulation of potassium ion transmembrane transport (GO:1901381)2.90073564
113response to auditory stimulus (GO:0010996)2.89828999
114detection of light stimulus involved in sensory perception (GO:0050962)2.89485120
115detection of light stimulus involved in visual perception (GO:0050908)2.89485120
116negative regulation of hormone metabolic process (GO:0032351)2.89430581
117negative regulation of hormone biosynthetic process (GO:0032353)2.89430581
118adult walking behavior (GO:0007628)2.88712387
119cytoskeletal anchoring at plasma membrane (GO:0007016)2.88668414
120cell communication involved in cardiac conduction (GO:0086065)2.86156116
121bundle of His cell to Purkinje myocyte communication (GO:0086069)2.79101700
122negative regulation of erythrocyte differentiation (GO:0045647)2.77721159
123regulation of Rap GTPase activity (GO:0032317)2.76210363
124filopodium assembly (GO:0046847)2.74971408
125G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.74237957
126negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.71439319
127activation of Rac GTPase activity (GO:0032863)2.70266011
128protein localization to endosome (GO:0036010)2.69170312
129epithelial cell differentiation involved in prostate gland development (GO:0060742)2.66531922
130thymic T cell selection (GO:0045061)2.59965622
131mannose metabolic process (GO:0006013)2.53267805
132positive regulation of neurotransmitter secretion (GO:0001956)2.47188863
133membrane tubulation (GO:0097320)2.47052227
134cell migration in hindbrain (GO:0021535)2.46802239
135water homeostasis (GO:0030104)2.45710223
136positive regulation of neurotransmitter transport (GO:0051590)2.41197901
137myelin maintenance (GO:0043217)2.36946607
138cardiac conduction (GO:0061337)2.33223068
139epidermis development (GO:0008544)2.31396295
140regulation of heart rate by cardiac conduction (GO:0086091)2.28864300
141hair cycle (GO:0042633)2.27368013
142molting cycle (GO:0042303)2.27368013
143adenosine receptor signaling pathway (GO:0001973)2.24459012
144negative regulation of cell killing (GO:0031342)2.22860213
145negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.22860213

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.84115413
2SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.08420240
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.89565836
4JARID2_20064375_ChIP-Seq_MESCs_Mouse2.86409053
5DROSHA_22980978_ChIP-Seq_HELA_Human2.86144102
6RNF2_18974828_ChIP-Seq_MESCs_Mouse2.80032981
7EZH2_18974828_ChIP-Seq_MESCs_Mouse2.80032981
8JARID2_20075857_ChIP-Seq_MESCs_Mouse2.65871071
9MTF2_20144788_ChIP-Seq_MESCs_Mouse2.52543176
10GBX2_23144817_ChIP-Seq_PC3_Human2.52427252
11SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.52003119
12SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.47450281
13* REST_21632747_ChIP-Seq_MESCs_Mouse2.42604681
14EZH2_27294783_Chip-Seq_ESCs_Mouse2.42108466
15SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.40650231
16RARB_27405468_Chip-Seq_BRAIN_Mouse2.36269750
17SUZ12_27294783_Chip-Seq_ESCs_Mouse2.36243859
18SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.33791320
19EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.33683499
20IKZF1_21737484_ChIP-ChIP_HCT116_Human2.32550007
21EZH2_27304074_Chip-Seq_ESCs_Mouse2.26652518
22RNF2_27304074_Chip-Seq_ESCs_Mouse2.24875415
23EED_16625203_ChIP-ChIP_MESCs_Mouse2.17607897
24MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.11948480
25REST_18959480_ChIP-ChIP_MESCs_Mouse2.04500634
26STAT6_21828071_ChIP-Seq_BEAS2B_Human2.04241208
27KDM2B_26808549_Chip-Seq_DND41_Human1.96926331
28ERG_21242973_ChIP-ChIP_JURKAT_Human1.90011433
29KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.86603256
30RARG_19884340_ChIP-ChIP_MEFs_Mouse1.85779555
31RACK7_27058665_Chip-Seq_MCF-7_Human1.84220315
32AR_21572438_ChIP-Seq_LNCaP_Human1.80720231
33P63_26484246_Chip-Seq_KERATINOCYTES_Human1.76305459
34P68_20966046_ChIP-Seq_HELA_Human1.71702751
35TCF7_22412390_ChIP-Seq_EML_Mouse1.70753655
36ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.69075583
37VDR_21846776_ChIP-Seq_THP-1_Human1.68397277
38CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.65812904
39UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.65797175
40TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.65724648
41GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.59229893
42ELK3_25401928_ChIP-Seq_HUVEC_Human1.57486981
43SA1_27219007_Chip-Seq_ERYTHROID_Human1.52862305
44KDM2B_26808549_Chip-Seq_K562_Human1.52513435
45TP63_22573176_ChIP-Seq_HFKS_Human1.50796851
46CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.47540708
47DNAJC2_21179169_ChIP-ChIP_NT2_Human1.44635533
48TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.42589684
49TP63_17297297_ChIP-ChIP_HaCaT_Human1.41818706
50* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.41404129
51* CREB1_26743006_Chip-Seq_LNCaP_Human1.39165492
52RING1B_27294783_Chip-Seq_ESCs_Mouse1.38850135
53CTCF_27219007_Chip-Seq_ERYTHROID_Human1.38730145
54* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.37833981
55VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.36800575
56NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.34649732
57SMAD4_21799915_ChIP-Seq_A2780_Human1.34061774
58SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.28516518
59NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.28047555
60SRY_22984422_ChIP-ChIP_TESTIS_Rat1.27463130
61CTBP2_25329375_ChIP-Seq_LNCAP_Human1.25955828
62AR_19668381_ChIP-Seq_PC3_Human1.25254123
63WT1_25993318_ChIP-Seq_PODOCYTE_Human1.25053161
64KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.24283388
65RING1B_27294783_Chip-Seq_NPCs_Mouse1.23948985
66PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.22604131
67KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.22532596
68* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.22522153
69BCOR_27268052_Chip-Seq_Bcells_Human1.22418891
70ZNF217_24962896_ChIP-Seq_MCF-7_Human1.22105369
71* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.20844899
72* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.20753282
73SOX9_24532713_ChIP-Seq_HFSC_Mouse1.18489511
74ZNF274_21170338_ChIP-Seq_K562_Hela1.17783205
75RUNX1_27514584_Chip-Seq_MCF-7_Human1.17422379
76CTBP1_25329375_ChIP-Seq_LNCAP_Human1.16408531
77SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.16378954
78WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.16162042
79PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.15943278
80ZFP281_18757296_ChIP-ChIP_E14_Mouse1.15590400
81* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.15335695
82RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.13857277
83P300_27058665_Chip-Seq_ZR-75-30cells_Human1.13770432
84MAF_26560356_Chip-Seq_TH2_Human1.12425748
85MAF_26560356_Chip-Seq_TH1_Human1.09984745
86* SA1_27219007_Chip-Seq_Bcells_Human1.09733657
87THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.09092486
88SOX2_21211035_ChIP-Seq_LN229_Gbm1.09002481
89SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.08226287
90SMAD3_21741376_ChIP-Seq_HESCs_Human1.07313717
91VDR_24763502_ChIP-Seq_THP-1_Human1.07214168
92P53_22127205_ChIP-Seq_FIBROBLAST_Human1.06362747
93TP53_16413492_ChIP-PET_HCT116_Human1.06191844
94TET1_21451524_ChIP-Seq_MESCs_Mouse1.05890986
95OCT4_19829295_ChIP-Seq_ESCs_Human1.03928626
96* MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.03706150
97TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.03430813
98* CTCF_27219007_Chip-Seq_Bcells_Human1.03065417
99AR_25329375_ChIP-Seq_VCAP_Human1.02605620
100AHR_22903824_ChIP-Seq_MCF-7_Human1.02364800
101ARNT_22903824_ChIP-Seq_MCF-7_Human1.00585769
102STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.99804331
103STAT3_23295773_ChIP-Seq_U87_Human0.99143587
104TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.98807075
105KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.98457697
106* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.97757439
107SMAD3_21741376_ChIP-Seq_ESCs_Human0.97642071
108NR3C1_23031785_ChIP-Seq_PC12_Mouse0.97469485
109BCL6_27268052_Chip-Seq_Bcells_Human0.96725846
110ZFP281_27345836_Chip-Seq_ESCs_Mouse0.96538315
111MYC_22102868_ChIP-Seq_BL_Human0.96415527
112TP53_23651856_ChIP-Seq_MEFs_Mouse0.95322099
113SMAD4_21741376_ChIP-Seq_HESCs_Human0.95249043
114SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.95079096
115YAP1_20516196_ChIP-Seq_MESCs_Mouse0.94966282
116* E2F1_20622854_ChIP-Seq_HELA_Human0.94720345
117TET1_21490601_ChIP-Seq_MESCs_Mouse0.93649012
118MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.93601912
119GATA1_19941827_ChIP-Seq_MEL_Mouse0.93459122
120SMAD3_21741376_ChIP-Seq_EPCs_Human0.93361717
121RXR_22108803_ChIP-Seq_LS180_Human0.92939390
122ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.92902107
123BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.92576220
124GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92461745
125CDX2_19796622_ChIP-Seq_MESCs_Mouse0.92033432
126* KDM2B_26808549_Chip-Seq_SUP-B15_Human0.91949797
127CBX2_27304074_Chip-Seq_ESCs_Mouse0.91802620
128TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.91620394
129ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.91359891
130PIAS1_25552417_ChIP-Seq_VCAP_Human0.91186781
131ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.90560397
132SMAD_19615063_ChIP-ChIP_OVARY_Human0.90339058
133ESR1_21235772_ChIP-Seq_MCF-7_Human0.90089551
134RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.90060739
135CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.89995680
136SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.89437992
137SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.89437992
138KDM2B_26808549_Chip-Seq_JURKAT_Human0.88942050
139SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.88871441
140UBF1/2_26484160_Chip-Seq_HMECs_Human0.88848078
141TP53_20018659_ChIP-ChIP_R1E_Mouse0.88705295
142DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.86714706
143BMI1_23680149_ChIP-Seq_NPCS_Mouse0.85424388
144TCF4_23295773_ChIP-Seq_U87_Human0.84476780
145TOP2B_26459242_ChIP-Seq_MCF-7_Human0.83833505
146ESR2_21235772_ChIP-Seq_MCF-7_Human0.83092822
147ZNF263_19887448_ChIP-Seq_K562_Human0.82792770
148P300_19829295_ChIP-Seq_ESCs_Human0.82649113
149ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.82146030
150* SMC4_20622854_ChIP-Seq_HELA_Human0.80839207
151BCAT_22108803_ChIP-Seq_LS180_Human0.80516685
152* LXR_22292898_ChIP-Seq_THP-1_Human0.80359741
153SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.79158289
154OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.77532788

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.24852918
2MP0003635_abnormal_synaptic_transmissio3.94032120
3MP0003880_abnormal_central_pattern3.77489975
4MP0009046_muscle_twitch3.68504220
5MP0005551_abnormal_eye_electrophysiolog3.44458632
6MP0004270_analgesia3.40200362
7MP0005423_abnormal_somatic_nervous3.21206056
8MP0005409_darkened_coat_color3.16961436
9MP0004381_abnormal_hair_follicle3.08688282
10MP0009745_abnormal_behavioral_response2.98883835
11MP0002064_seizures2.92068386
12MP0002063_abnormal_learning/memory/cond2.90698611
13MP0003705_abnormal_hypodermis_morpholog2.69040812
14MP0003011_delayed_dark_adaptation2.68374868
15MP0002272_abnormal_nervous_system2.68198098
16MP0008569_lethality_at_weaning2.65735833
17MP0000566_synostosis2.60822055
18MP0003453_abnormal_keratinocyte_physiol2.60650160
19MP0002734_abnormal_mechanical_nocicepti2.50954895
20MP0001968_abnormal_touch/_nociception2.49769903
21MP0001486_abnormal_startle_reflex2.44099548
22MP0002572_abnormal_emotion/affect_behav2.40540485
23MP0006072_abnormal_retinal_apoptosis2.28649843
24MP0005253_abnormal_eye_physiology2.12122651
25MP0001501_abnormal_sleep_pattern2.10400559
26MP0004885_abnormal_endolymph1.98735073
27MP0002067_abnormal_sensory_capabilities1.98286154
28MP0002184_abnormal_innervation1.93180152
29MP0001440_abnormal_grooming_behavior1.92362326
30MP0001849_ear_inflammation1.86007476
31MP0010234_abnormal_vibrissa_follicle1.82633249
32MP0002060_abnormal_skin_morphology1.79536775
33MP0001216_abnormal_epidermal_layer1.78070059
34MP0002736_abnormal_nociception_after1.76634202
35MP0002735_abnormal_chemical_nociception1.76431474
36MP0003329_amyloid_beta_deposits1.75052401
37MP0004947_skin_inflammation1.71666847
38MP0003879_abnormal_hair_cell1.70727992
39MP0005501_abnormal_skin_physiology1.69594631
40MP0000762_abnormal_tongue_morphology1.68720569
41MP0004145_abnormal_muscle_electrophysio1.67375491
42MP0002882_abnormal_neuron_morphology1.62214768
43MP0004858_abnormal_nervous_system1.61536118
44MP0008260_abnormal_autophagy1.60689491
45MP0009780_abnormal_chondrocyte_physiolo1.57749351
46MP0001970_abnormal_pain_threshold1.56739235
47MP0002098_abnormal_vibrissa_morphology1.55923370
48MP0002229_neurodegeneration1.54994464
49MP0001984_abnormal_olfaction1.54733927
50MP0001986_abnormal_taste_sensitivity1.54248944
51MP0002557_abnormal_social/conspecific_i1.53240750
52MP0003566_abnormal_cell_adhesion1.52704353
53MP0002733_abnormal_thermal_nociception1.50603405
54MP0002909_abnormal_adrenal_gland1.48886989
55MP0002090_abnormal_vision1.48650931
56MP0001502_abnormal_circadian_rhythm1.47605362
57MP0004811_abnormal_neuron_physiology1.47172449
58MP0005275_abnormal_skin_tensile1.43875202
59MP0000579_abnormal_nail_morphology1.42088974
60MP0000778_abnormal_nervous_system1.41703432
61MP0003172_abnormal_lysosome_physiology1.39695578
62MP0000955_abnormal_spinal_cord1.39513433
63MP0004924_abnormal_behavior1.35751065
64MP0005386_behavior/neurological_phenoty1.35751065
65MP0003763_abnormal_thymus_physiology1.31976152
66MP0000678_abnormal_parathyroid_gland1.31804919
67MP0002822_catalepsy1.31608280
68MP0002066_abnormal_motor_capabilities/c1.29538844
69MP0005394_taste/olfaction_phenotype1.28324528
70MP0005499_abnormal_olfactory_system1.28324528
71MP0000383_abnormal_hair_follicle1.27195155
72MP0000377_abnormal_hair_follicle1.25587378
73MP0002796_impaired_skin_barrier1.25444061
74MP0005195_abnormal_posterior_eye1.22204933
75MP0001851_eye_inflammation1.18372376
76MP0003633_abnormal_nervous_system1.18106064
77MP0004742_abnormal_vestibular_system1.17988237
78MP0002752_abnormal_somatic_nervous1.14184205
79MP0004142_abnormal_muscle_tone1.12378373
80MP0001348_abnormal_lacrimal_gland1.10311062
81MP0002638_abnormal_pupillary_reflex1.08322978
82MP0003631_nervous_system_phenotype1.03838187
83MP0005023_abnormal_wound_healing1.03370127
84MP0001765_abnormal_ion_homeostasis1.02048932
85MP0003183_abnormal_peptide_metabolism1.01429689
86MP0003632_abnormal_nervous_system1.00743113
87MP0009931_abnormal_skin_appearance1.00123303
88MP0002152_abnormal_brain_morphology0.99673702
89MP0002234_abnormal_pharynx_morphology0.99068852
90MP0010386_abnormal_urinary_bladder0.98378470
91MP0000367_abnormal_coat/_hair0.95602504
92MP0003283_abnormal_digestive_organ0.94248741
93MP0008961_abnormal_basal_metabolism0.93904598
94MP0003787_abnormal_imprinting0.91492131
95MP0008872_abnormal_physiological_respon0.91221344
96MP0001177_atelectasis0.90319859
97MP0000751_myopathy0.87874306
98MP0003436_decreased_susceptibility_to0.86147941
99MP0003191_abnormal_cellular_cholesterol0.84551352
100MP0001963_abnormal_hearing_physiology0.79289132
101MP0003634_abnormal_glial_cell0.78948910
102MP0002069_abnormal_eating/drinking_beha0.78608723
103MP0004215_abnormal_myocardial_fiber0.77875022
104MP0004233_abnormal_muscle_weight0.77834516
105MP0001958_emphysema0.77284116
106MP0000013_abnormal_adipose_tissue0.76819220
107MP0004264_abnormal_extraembryonic_tissu0.76153000
108MP0005391_vision/eye_phenotype0.75461078
109MP0005187_abnormal_penis_morphology0.75023857
110MP0000920_abnormal_myelination0.74130870
111MP0004130_abnormal_muscle_cell0.73996803
112MP0004510_myositis0.72939050
113MP0003123_paternal_imprinting0.72711700
114MP0002653_abnormal_ependyma_morphology0.72289951
115MP0001324_abnormal_eye_pigmentation0.71596515
116MP0005646_abnormal_pituitary_gland0.71450293
117MP0001346_abnormal_lacrimal_gland0.71379767
118MP0003690_abnormal_glial_cell0.69657310
119MP0005166_decreased_susceptibility_to0.68658481
120MP0008874_decreased_physiological_sensi0.68638815
121MP0003045_fibrosis0.68395664
122MP0003075_altered_response_to0.68175127
123MP0010771_integument_phenotype0.65023223
124MP0004085_abnormal_heartbeat0.64749816
125MP0002254_reproductive_system_inflammat0.64498639
126MP0004043_abnormal_pH_regulation0.63507932
127MP0005076_abnormal_cell_differentiation0.63481144
128MP0000604_amyloidosis0.63458825
129MP0001299_abnormal_eye_distance/0.62054159
130MP0001188_hyperpigmentation0.61801495
131MP0000467_abnormal_esophagus_morphology0.61571662
132MP0003137_abnormal_impulse_conducting0.60889892
133MP0001485_abnormal_pinna_reflex0.60756858
134MP0002249_abnormal_larynx_morphology0.60350783
135MP0005645_abnormal_hypothalamus_physiol0.59871363
136MP0000427_abnormal_hair_cycle0.59626927
137MP0010678_abnormal_skin_adnexa0.59612926
138MP0008789_abnormal_olfactory_epithelium0.58504739
139MP0004484_altered_response_of0.58122161
140MP0002089_abnormal_postnatal_growth/wei0.57296164
141MP0005388_respiratory_system_phenotype0.56656787
142MP0002133_abnormal_respiratory_system0.56656787
143MP0003300_gastrointestinal_ulcer0.56100124
144MP0003091_abnormal_cell_migration0.56055989
145MP0001191_abnormal_skin_condition0.55129082

Predicted human phenotypes

RankGene SetZ-score
1Congenital stationary night blindness (HP:0007642)6.04417957
2Focal motor seizures (HP:0011153)5.77833112
3Abnormality of nail color (HP:0100643)5.46872251
4Myokymia (HP:0002411)5.41740197
5Visual hallucinations (HP:0002367)5.16945876
6Progressive cerebellar ataxia (HP:0002073)5.15326529
7Onycholysis (HP:0001806)5.11141093
8Thick nail (HP:0001805)4.96977974
9Action tremor (HP:0002345)4.92024982
10Atrophic scars (HP:0001075)4.89655624
11Focal seizures (HP:0007359)4.79097041
12Central scotoma (HP:0000603)4.59763684
13Bony spicule pigmentary retinopathy (HP:0007737)4.51798809
14Obstructive sleep apnea (HP:0002870)4.28417375
15Febrile seizures (HP:0002373)4.17994372
16Abnormal rod and cone electroretinograms (HP:0008323)4.15317704
17Absent rod-and cone-mediated responses on ERG (HP:0007688)4.06249941
18Palmoplantar hyperkeratosis (HP:0000972)4.05946293
19Epileptic encephalopathy (HP:0200134)4.03493926
20Atonic seizures (HP:0010819)4.00233414
21Abnormality of macular pigmentation (HP:0008002)3.98096230
22Nail dystrophy (HP:0008404)3.90680246
23Alopecia of scalp (HP:0002293)3.87639837
24Gaze-evoked nystagmus (HP:0000640)3.86272112
25Dysdiadochokinesis (HP:0002075)3.86241466
26Palmar hyperkeratosis (HP:0010765)3.75817953
27Absence seizures (HP:0002121)3.68475594
28Scotoma (HP:0000575)3.67194534
29Abnormal blistering of the skin (HP:0008066)3.63801584
30Broad-based gait (HP:0002136)3.32444778
31Intention tremor (HP:0002080)3.31761571
32Ventricular fibrillation (HP:0001663)3.31601981
33Chorioretinal atrophy (HP:0000533)3.22385224
34Genetic anticipation (HP:0003743)3.21616571
35Decreased central vision (HP:0007663)3.20768087
36Dysmetric saccades (HP:0000641)3.17358331
37Dialeptic seizures (HP:0011146)3.16520332
38Generalized tonic-clonic seizures (HP:0002069)3.12372703
39Ridged nail (HP:0001807)3.11506679
40Pigmentary retinal degeneration (HP:0001146)3.10823150
41Dysmetria (HP:0001310)3.09068150
42Impaired smooth pursuit (HP:0007772)3.08696478
43Scanning speech (HP:0002168)3.08694076
44Abnormality of the lower motor neuron (HP:0002366)3.08366241
45Hemiplegia (HP:0002301)3.00377144
46Papilledema (HP:0001085)2.99847331
47Hypoplasia of dental enamel (HP:0006297)2.99218208
48Truncal ataxia (HP:0002078)2.97886790
49Supranuclear gaze palsy (HP:0000605)2.96709632
50Abnormal hair laboratory examination (HP:0003328)2.96554210
51Depression (HP:0000716)2.89052194
52Cerebral inclusion bodies (HP:0100314)2.87765876
53Abnormality of ocular smooth pursuit (HP:0000617)2.84005365
54Lip pit (HP:0100267)2.81565764
55Choroideremia (HP:0001139)2.78234578
56Abnormality of the salivary glands (HP:0010286)2.75661480
57Right ventricular cardiomyopathy (HP:0011663)2.75588670
58Poor eye contact (HP:0000817)2.74100303
59Dyschromatopsia (HP:0007641)2.73627158
60Abolished electroretinogram (ERG) (HP:0000550)2.69025256
61Popliteal pterygium (HP:0009756)2.68756708
62Pendular nystagmus (HP:0012043)2.65369838
63Increased IgE level (HP:0003212)2.64820672
64Diplopia (HP:0000651)2.62881339
65Abnormality of binocular vision (HP:0011514)2.62881339
66Hemiparesis (HP:0001269)2.62123393
67Impaired social interactions (HP:0000735)2.59093985
68Abnormal social behavior (HP:0012433)2.59093985
69Mutism (HP:0002300)2.50322120
70Macular degeneration (HP:0000608)2.47605366
71Postural instability (HP:0002172)2.46536821
72Ankle clonus (HP:0011448)2.46480978
73Akinesia (HP:0002304)2.45144424
74Attenuation of retinal blood vessels (HP:0007843)2.41703533
75Posterior subcapsular cataract (HP:0007787)2.40571080
76Anxiety (HP:0000739)2.38808688
77Fragile skin (HP:0001030)2.34361440
78Annular pancreas (HP:0001734)2.33553484
79Sparse scalp hair (HP:0002209)2.32737577
80Neuronal loss in central nervous system (HP:0002529)2.32679450
81Horizontal nystagmus (HP:0000666)2.31542524
82Malnutrition (HP:0004395)2.29192618
83Broad face (HP:0000283)2.28133975
84Impaired vibration sensation in the lower limbs (HP:0002166)2.27647967
85Type II diabetes mellitus (HP:0005978)2.26924358
86Milia (HP:0001056)2.25974845
87Urinary bladder sphincter dysfunction (HP:0002839)2.24953264
88Abnormal eating behavior (HP:0100738)2.23660384
89Pterygium (HP:0001059)2.22946221
90Pustule (HP:0200039)2.22379603
91Rapidly progressive (HP:0003678)2.21754493
92Status epilepticus (HP:0002133)2.21566846
93Thin bony cortex (HP:0002753)2.20058240
94Photophobia (HP:0000613)2.19212360
95Megalencephaly (HP:0001355)2.18296438
96Amblyopia (HP:0000646)2.17704965
97Stereotypic behavior (HP:0000733)2.17374258
98Abnormality of the neuromuscular junction (HP:0003398)2.15293743
99Fatigable weakness (HP:0003473)2.15293743
100Woolly hair (HP:0002224)2.12484266
101Increased corneal curvature (HP:0100692)2.12097546
102Keratoconus (HP:0000563)2.12097546
103Eczematoid dermatitis (HP:0000976)2.10280716
104Neonatal onset (HP:0003623)2.09212167
105Insomnia (HP:0100785)2.02669913
106Decreased electroretinogram (ERG) amplitude (HP:0000654)2.01790871
107Abnormality of secondary sexual hair (HP:0009888)2.01633351
108Abnormality of the axillary hair (HP:0100134)2.01633351
109Tetraplegia (HP:0002445)2.00142034
110Severe visual impairment (HP:0001141)1.99732301
111Oligodontia (HP:0000677)1.99458128
112Corneal erosion (HP:0200020)1.98530149
113Abnormality of saccadic eye movements (HP:0000570)1.96218431
114Pointed chin (HP:0000307)1.96204646
115Abnormality of oral frenula (HP:0000190)1.95747070
116Spastic gait (HP:0002064)1.94743124
117Fragile nails (HP:0001808)1.93674876
118Lower limb asymmetry (HP:0100559)1.91472303
119Aplasia involving bones of the upper limbs (HP:0009823)1.87546443
120Aplasia of the phalanges of the hand (HP:0009802)1.87546443
121Aplasia involving bones of the extremities (HP:0009825)1.87546443
122Distal upper limb amyotrophy (HP:0007149)1.87452542
123Upper limb amyotrophy (HP:0009129)1.87452542
124Ankyloglossia (HP:0010296)1.87255263
125Bundle branch block (HP:0011710)1.85673186
126Torticollis (HP:0000473)1.84764638
127Erythema (HP:0010783)1.84548737
128Neurofibrillary tangles (HP:0002185)1.84271494
129Aqueductal stenosis (HP:0002410)1.83805066
130Anonychia (HP:0001798)1.83327989
131Excessive salivation (HP:0003781)1.83082592
132Drooling (HP:0002307)1.83082592
133Postural tremor (HP:0002174)1.83054224
134Gait ataxia (HP:0002066)1.82869525
135Split foot (HP:0001839)1.82234744
136Selective tooth agenesis (HP:0001592)1.81474051
137Advanced eruption of teeth (HP:0006288)1.80436353
138Neoplasm of the heart (HP:0100544)1.80398508
139Pili torti (HP:0003777)1.79984050
140Bronchomalacia (HP:0002780)1.79926090
141Bradykinesia (HP:0002067)1.78608694
142Cheilitis (HP:0100825)1.77922879
143Polygenic inheritance (HP:0010982)1.76568335
144Vitreoretinal degeneration (HP:0000655)1.76323900
145Turricephaly (HP:0000262)1.75837936
146Cone-rod dystrophy (HP:0000548)1.75418637
147Spinal canal stenosis (HP:0003416)1.75347545
148Sleep apnea (HP:0010535)1.74931458
149Abnormality of the labia majora (HP:0012881)1.74259111
150Urinary urgency (HP:0000012)1.72347635
151Plantar hyperkeratosis (HP:0007556)1.72305053
152Abnormality of the corticospinal tract (HP:0002492)1.72170025
153Focal dystonia (HP:0004373)1.72055793
154Hypotrichosis (HP:0001006)1.71040128
155Natal tooth (HP:0000695)1.69596266
156Laryngomalacia (HP:0001601)1.68369034
157Global brain atrophy (HP:0002283)1.67430112
158Fetal akinesia sequence (HP:0001989)1.66148328
159Hyperhidrosis (HP:0000975)1.64442307
160Cerebral aneurysm (HP:0004944)1.64264644
161Rigidity (HP:0002063)1.61328151
162Carious teeth (HP:0000670)1.59277628
163Hypoplastic labia majora (HP:0000059)1.55583646
164Hypodontia (HP:0000668)1.55540427
165Germ cell neoplasia (HP:0100728)1.54773464
166Skin ulcer (HP:0200042)1.54612372
167Palmoplantar keratoderma (HP:0000982)1.53680344
168Clonus (HP:0002169)1.53429730

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K93.77997361
2NTRK33.73153231
3EPHA43.00743241
4TRIB32.73747914
5PAK62.64821951
6MARK12.64159842
7MAP3K42.64101208
8MINK12.58464276
9DAPK22.58413565
10RIPK12.42215721
11SIK12.40695509
12CAMKK12.40063433
13STK382.26683066
14NTRK22.26079257
15MST1R2.24674604
16PRKD32.13499274
17MAPK152.07878266
18KSR21.82631091
19CAMKK21.81962267
20MAP2K41.78721312
21MAP2K71.78315747
22RIPK41.71576883
23EPHA21.68140369
24CDK51.49222837
25ERN11.47715581
26SIK21.47154757
27NTRK11.46607779
28PRPF4B1.46258725
29MAP3K21.45439715
30TYRO31.41308742
31CDK191.40886765
32MAP4K11.35403820
33GRK11.33446243
34WNK11.26879038
35KSR11.26259906
36PINK11.25562339
37CAMK11.24249053
38GRK51.23498054
39PRKCG1.19825496
40STK111.18587550
41TNIK1.17656844
42EPHB11.12989872
43PNCK1.12737501
44TAOK11.10377590
45SGK4941.07452397
46SGK2231.07452397
47PRKCH1.05551479
48PLK21.04130562
49PHKG11.03377236
50PHKG21.03377236
51MET1.02518867
52MAP3K61.02081255
53FER1.00914831
54ALK0.99712254
55FES0.98372679
56DAPK10.98319294
57JAK10.97787475
58GRK60.92210107
59DYRK1A0.91963788
60CDK150.90733009
61SMG10.90627784
62ZAP700.89869672
63MAPK130.88015876
64UHMK10.87993565
65CDK180.87971786
66SGK20.87630947
67SGK30.87053163
68MAP3K70.86861727
69RET0.85798643
70MAP3K130.85168064
71RPS6KA20.84933473
72CAMK1G0.84133213
73CAMK2A0.82465377
74MAP3K120.81537250
75MAP2K60.81307193
76LMTK20.80833593
77CDK120.80132610
78CDK11A0.79824261
79CDK140.78581902
80CDC42BPA0.77888100
81EEF2K0.77759060
82NEK10.76685960
83PTK60.76374137
84CAMK40.75985558
85SGK10.75938957
86SIK30.75654095
87MARK20.72225546
88FGFR30.71394973
89NME10.71343313
90OXSR10.71154883
91MAP3K30.69964428
92PDK10.69490629
93PAK30.68968933
94TNK20.67639828
95CSK0.65905449
96MAPKAPK30.64909523
97PDGFRA0.64088440
98CAMK2B0.62781022
99RPS6KA30.61393242
100LATS20.61053662
101MAP3K10.58912033
102CAMK2D0.57310890
103MAP3K110.56767007
104FGFR20.56464610
105ERBB20.56358340
106BLK0.55853682
107NEK60.55652911
108FYN0.55513578
109PDPK10.55404856
110MAPK70.54724798
111EPHB20.54425566
112PRKCZ0.54031534
113IRAK20.53543437
114CAMK2G0.52474247
115PDGFRB0.51284040
116MAPKAPK50.51281957
117TYK20.51000809
118PRKD10.50565557
119DDR20.49858431
120CASK0.49848365
121PTK2B0.49726599
122ROCK20.49569616
123MAPK100.47998806
124FGFR40.47822500
125BRAF0.45963893
126MAPK120.42940891
127ICK0.42665313
128HIPK20.42016740
129ARAF0.41688167
130PRKCB0.41656520
131RAF10.40665517
132ITK0.39979597
133MAPK80.39383917
134PRKD20.38491717
135BMX0.38394287
136PTK20.38145311
137PRKCE0.37734649
138MTOR0.37444893
139DMPK0.37230182
140BTK0.37154653

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047444.04187343
2Nicotine addiction_Homo sapiens_hsa050333.62921407
3Synaptic vesicle cycle_Homo sapiens_hsa047213.08437456
4Glutamatergic synapse_Homo sapiens_hsa047242.70062061
5GABAergic synapse_Homo sapiens_hsa047272.64944331
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.64156763
7Circadian entrainment_Homo sapiens_hsa047132.62863418
8Long-term potentiation_Homo sapiens_hsa047202.56016010
9Olfactory transduction_Homo sapiens_hsa047402.37756965
10Morphine addiction_Homo sapiens_hsa050322.24651976
11Salivary secretion_Homo sapiens_hsa049702.23392746
12Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.18372322
13Amphetamine addiction_Homo sapiens_hsa050312.01004957
14Gastric acid secretion_Homo sapiens_hsa049711.95300669
15Dopaminergic synapse_Homo sapiens_hsa047281.87787795
16Aldosterone synthesis and secretion_Homo sapiens_hsa049251.86281037
17Insulin secretion_Homo sapiens_hsa049111.86136652
18Long-term depression_Homo sapiens_hsa047301.84559508
19Cholinergic synapse_Homo sapiens_hsa047251.83867220
20Taste transduction_Homo sapiens_hsa047421.68523968
21Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.65268631
22Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.61987043
23Oxytocin signaling pathway_Homo sapiens_hsa049211.61982229
24Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.61038023
25Renin secretion_Homo sapiens_hsa049241.47663781
26Calcium signaling pathway_Homo sapiens_hsa040201.46631594
27GnRH signaling pathway_Homo sapiens_hsa049121.44620415
28Phosphatidylinositol signaling system_Homo sapiens_hsa040701.44011072
29Serotonergic synapse_Homo sapiens_hsa047261.38351515
30Nitrogen metabolism_Homo sapiens_hsa009101.33895600
31Type II diabetes mellitus_Homo sapiens_hsa049301.27695037
32Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.26534502
33Notch signaling pathway_Homo sapiens_hsa043301.26529026
34cAMP signaling pathway_Homo sapiens_hsa040241.22064112
35Pancreatic secretion_Homo sapiens_hsa049721.15099204
36Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.14943038
37Gap junction_Homo sapiens_hsa045401.14740731
38Estrogen signaling pathway_Homo sapiens_hsa049151.14107361
39Cocaine addiction_Homo sapiens_hsa050301.13287596
40cGMP-PKG signaling pathway_Homo sapiens_hsa040221.10276174
41Melanogenesis_Homo sapiens_hsa049161.01992154
42Glioma_Homo sapiens_hsa052140.96766528
43Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.95775202
44Axon guidance_Homo sapiens_hsa043600.93525262
45Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.91971831
46Carbohydrate digestion and absorption_Homo sapiens_hsa049730.91782253
47Vascular smooth muscle contraction_Homo sapiens_hsa042700.91436954
48Acute myeloid leukemia_Homo sapiens_hsa052210.91422592
49Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.91304995
50Thyroid hormone synthesis_Homo sapiens_hsa049180.90951567
51Phospholipase D signaling pathway_Homo sapiens_hsa040720.88485459
52ErbB signaling pathway_Homo sapiens_hsa040120.87357644
53T cell receptor signaling pathway_Homo sapiens_hsa046600.87041934
54Cardiac muscle contraction_Homo sapiens_hsa042600.85996060
55B cell receptor signaling pathway_Homo sapiens_hsa046620.85227892
56ECM-receptor interaction_Homo sapiens_hsa045120.84205940
57Dilated cardiomyopathy_Homo sapiens_hsa054140.81954903
58Circadian rhythm_Homo sapiens_hsa047100.80077524
59Collecting duct acid secretion_Homo sapiens_hsa049660.78837840
60Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.77544756
61Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.77316410
62Amoebiasis_Homo sapiens_hsa051460.73566238
63Choline metabolism in cancer_Homo sapiens_hsa052310.72812241
64Chronic myeloid leukemia_Homo sapiens_hsa052200.72552688
65Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.71800343
66Bile secretion_Homo sapiens_hsa049760.68247723
67Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.68107017
68Oocyte meiosis_Homo sapiens_hsa041140.68044403
69Toxoplasmosis_Homo sapiens_hsa051450.67835289
70VEGF signaling pathway_Homo sapiens_hsa043700.67586805
71Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.66047065
72mTOR signaling pathway_Homo sapiens_hsa041500.65667796
73Thyroid hormone signaling pathway_Homo sapiens_hsa049190.65569669
74Focal adhesion_Homo sapiens_hsa045100.65557688
75MAPK signaling pathway_Homo sapiens_hsa040100.64714928
76Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.64307907
77Dorso-ventral axis formation_Homo sapiens_hsa043200.63470259
78Prion diseases_Homo sapiens_hsa050200.63183134
79* Inositol phosphate metabolism_Homo sapiens_hsa005620.59931393
80Leukocyte transendothelial migration_Homo sapiens_hsa046700.58866701
81AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.57059688
82Osteoclast differentiation_Homo sapiens_hsa043800.56913372
83Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.55214153
84Small cell lung cancer_Homo sapiens_hsa052220.53978095
85Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.53895371
86Sphingolipid metabolism_Homo sapiens_hsa006000.52884221
87Hepatitis C_Homo sapiens_hsa051600.51920969
88Longevity regulating pathway - mammal_Homo sapiens_hsa042110.51226576
89Pancreatic cancer_Homo sapiens_hsa052120.50645877
90Neurotrophin signaling pathway_Homo sapiens_hsa047220.50135770
91Tuberculosis_Homo sapiens_hsa051520.50133290
92Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.50061237
93Prolactin signaling pathway_Homo sapiens_hsa049170.49986798
94Sphingolipid signaling pathway_Homo sapiens_hsa040710.48941410
95Rap1 signaling pathway_Homo sapiens_hsa040150.48317947
96Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.48284301
97Glucagon signaling pathway_Homo sapiens_hsa049220.47968155
98Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.47913690
99Endocytosis_Homo sapiens_hsa041440.47386001
100Ras signaling pathway_Homo sapiens_hsa040140.45493622
101Endometrial cancer_Homo sapiens_hsa052130.45005851
102Vibrio cholerae infection_Homo sapiens_hsa051100.44878701
103Mineral absorption_Homo sapiens_hsa049780.44857063
104Wnt signaling pathway_Homo sapiens_hsa043100.44844046
105Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.44229976
106Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.42797481
107Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.41932462
108Tight junction_Homo sapiens_hsa045300.41630229
109Non-small cell lung cancer_Homo sapiens_hsa052230.38760094
110Central carbon metabolism in cancer_Homo sapiens_hsa052300.34113723
111Renal cell carcinoma_Homo sapiens_hsa052110.33930086
112Hedgehog signaling pathway_Homo sapiens_hsa043400.32178908
113Ovarian steroidogenesis_Homo sapiens_hsa049130.31782973
114Chemokine signaling pathway_Homo sapiens_hsa040620.31545547
115Proteoglycans in cancer_Homo sapiens_hsa052050.31171422
116Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.29874021
117Glycerophospholipid metabolism_Homo sapiens_hsa005640.29605657
118Alcoholism_Homo sapiens_hsa050340.29530676
119Insulin signaling pathway_Homo sapiens_hsa049100.26647402
120Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.26577944
121Hippo signaling pathway_Homo sapiens_hsa043900.25473684
122Platelet activation_Homo sapiens_hsa046110.25076609
123Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.24242648
124Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.23678616

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