PLCL1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1myelination (GO:0042552)5.94780763
2ensheathment of neurons (GO:0007272)5.93416529
3axon ensheathment (GO:0008366)5.93416529
4sarcoplasmic reticulum calcium ion transport (GO:0070296)5.90874914
5fatty acid elongation (GO:0030497)5.77843287
6regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)5.66237572
7actin-myosin filament sliding (GO:0033275)5.56488349
8muscle filament sliding (GO:0030049)5.56488349
9positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)5.54832633
10regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO5.51127898
11regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)5.47486537
12membrane depolarization during cardiac muscle cell action potential (GO:0086012)5.23475680
13regulation of relaxation of muscle (GO:1901077)5.22683015
14cell communication by electrical coupling involved in cardiac conduction (GO:0086064)5.16200876
15long-chain fatty acid biosynthetic process (GO:0042759)5.07568472
16myofibril assembly (GO:0030239)5.04476524
17regulation of actin filament-based movement (GO:1903115)4.92358637
18cardiac muscle contraction (GO:0060048)4.89580667
19cardiac myofibril assembly (GO:0055003)4.84167203
20sarcomere organization (GO:0045214)4.77412234
21negative regulation of neurotransmitter transport (GO:0051589)4.76639048
22negative regulation of neurotransmitter secretion (GO:0046929)4.75338654
23cardiac muscle hypertrophy (GO:0003300)4.72345762
24L-amino acid import (GO:0043092)4.67862277
25actin-mediated cell contraction (GO:0070252)4.58511589
26regulation of cell communication by electrical coupling (GO:0010649)4.57562909
27striated muscle hypertrophy (GO:0014897)4.46666469
28striated muscle contraction (GO:0006941)4.46092282
29myelin maintenance (GO:0043217)4.44148160
30regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)4.39524956
31cell communication by electrical coupling (GO:0010644)4.22148934
32presynaptic membrane organization (GO:0097090)4.12828332
33response to inactivity (GO:0014854)4.06462428
34response to stimulus involved in regulation of muscle adaptation (GO:0014874)4.03350933
35presynaptic membrane assembly (GO:0097105)3.98702527
36muscle hypertrophy (GO:0014896)3.97950890
37glycerophospholipid catabolic process (GO:0046475)3.97118925
38relaxation of cardiac muscle (GO:0055119)3.96743597
39neuron cell-cell adhesion (GO:0007158)3.94302313
40eye photoreceptor cell differentiation (GO:0001754)3.93618582
41photoreceptor cell differentiation (GO:0046530)3.93618582
42positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.92782551
43negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.91238310
44regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.83866515
45oligodendrocyte differentiation (GO:0048709)3.82925158
46regulation of cardiac muscle cell contraction (GO:0086004)3.76395701
47cardiac muscle adaptation (GO:0014887)3.73486889
48cardiac muscle hypertrophy in response to stress (GO:0014898)3.73486889
49muscle hypertrophy in response to stress (GO:0003299)3.73486889
50negative regulation of potassium ion transmembrane transport (GO:1901380)3.72574482
51negative regulation of protein localization to cell surface (GO:2000009)3.72019471
52regulation of striated muscle contraction (GO:0006942)3.71406972
53cell communication involved in cardiac conduction (GO:0086065)3.70506552
54regulation of skeletal muscle contraction (GO:0014819)3.69005120
55regulation of collateral sprouting (GO:0048670)3.66482913
56import into cell (GO:0098657)3.62698234
57establishment of mitochondrion localization (GO:0051654)3.62089733
58detection of calcium ion (GO:0005513)3.56897570
59neuronal action potential propagation (GO:0019227)3.55677375
60amino acid import (GO:0043090)3.53515333
61actin filament-based movement (GO:0030048)3.52793618
62astrocyte development (GO:0014002)3.50578667
63asymmetric protein localization (GO:0008105)3.49938662
64adult walking behavior (GO:0007628)3.49405937
65regulation of calcium ion transmembrane transporter activity (GO:1901019)3.44411302
66regulation of calcium ion transmembrane transport (GO:1903169)3.44411302
67regulation of membrane repolarization (GO:0060306)3.44146561
68actomyosin structure organization (GO:0031032)3.44073401
69skeletal muscle contraction (GO:0003009)3.41960969
70apical protein localization (GO:0045176)3.41708963
71transmission of nerve impulse (GO:0019226)3.40858150
72positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.39956929
73cerebral cortex radially oriented cell migration (GO:0021799)3.39375500
74relaxation of muscle (GO:0090075)3.34827148
75regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.33917943
76response to epinephrine (GO:0071871)3.33854550
77negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.33235077
78neuron remodeling (GO:0016322)3.29599952
79positive regulation of phosphoprotein phosphatase activity (GO:0032516)3.29447614
80peptidyl-tyrosine autophosphorylation (GO:0038083)3.26911930
81regulation of cardiac muscle contraction (GO:0055117)3.26520607
82response to methylmercury (GO:0051597)3.24694374
83positive regulation of oligodendrocyte differentiation (GO:0048714)3.22080628
84cardiac muscle tissue morphogenesis (GO:0055008)3.16975770
85sodium ion export (GO:0071436)3.15556581
86regulation of the force of heart contraction (GO:0002026)3.14248824
87neurotransmitter uptake (GO:0001504)3.13923484
88substantia nigra development (GO:0021762)3.07699823
89activation of protein kinase A activity (GO:0034199)3.05678134
90muscle contraction (GO:0006936)3.05588801
91negative regulation of axonogenesis (GO:0050771)3.03918142
92striated muscle adaptation (GO:0014888)3.02553115
93cellular potassium ion homeostasis (GO:0030007)3.02511840
94potassium ion import (GO:0010107)3.02380358
95nerve growth factor signaling pathway (GO:0038180)3.01652837
96adult heart development (GO:0007512)3.00512443
97cardiac muscle cell development (GO:0055013)3.00318180
98neuronal ion channel clustering (GO:0045161)2.99425869
99peripheral nervous system axon ensheathment (GO:0032292)2.99246786
100myelination in peripheral nervous system (GO:0022011)2.99246786
101dendritic spine morphogenesis (GO:0060997)2.98365362
102membrane depolarization during action potential (GO:0086010)2.97682461
103cardiac cell development (GO:0055006)2.97359324
104neuron recognition (GO:0008038)2.96049558
105muscle tissue morphogenesis (GO:0060415)2.95528125
106membrane tubulation (GO:0097320)2.95304964
107creatine metabolic process (GO:0006600)2.94767970
108cholesterol biosynthetic process (GO:0006695)2.93843615
109muscle system process (GO:0003012)2.88956856
110regulation of heart rate (GO:0002027)2.88739994
111regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.85196926
112protein palmitoylation (GO:0018345)2.84244083
113ventricular cardiac muscle cell action potential (GO:0086005)2.83620671
114ventricular cardiac muscle tissue morphogenesis (GO:0055010)2.82143133
115mating behavior (GO:0007617)2.80239941
116positive regulation of action potential (GO:0045760)2.78440598
117response to redox state (GO:0051775)2.78245133
118synaptic vesicle maturation (GO:0016188)2.77369600
119negative regulation of synaptic transmission, GABAergic (GO:0032229)2.77157039
120positive regulation of cation channel activity (GO:2001259)2.75175425
121regulation of heart contraction (GO:0008016)2.73798696
122regulation of cation channel activity (GO:2001257)2.72790838
123amyloid precursor protein metabolic process (GO:0042982)2.72678135
124limb bud formation (GO:0060174)2.69667100
125negative regulation of inclusion body assembly (GO:0090084)2.69310469
126cerebellar granule cell differentiation (GO:0021707)2.68693183
127negative regulation of axon extension (GO:0030517)2.68515093
128cellular response to epinephrine stimulus (GO:0071872)2.67642344
129cardiac muscle cell action potential (GO:0086001)2.66956082
130positive regulation of potassium ion transmembrane transport (GO:1901381)2.66534516
131long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.66531317
132negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.65767153
133response to lipoprotein particle (GO:0055094)2.65686186
134magnesium ion transport (GO:0015693)2.65014620
135cGMP-mediated signaling (GO:0019934)2.64151041
136axon development (GO:0061564)2.63133959
137regulation of dopamine metabolic process (GO:0042053)2.61507608
138regulation of catecholamine metabolic process (GO:0042069)2.61507608
139positive regulation of potassium ion transport (GO:0043268)2.60996695
140axonal fasciculation (GO:0007413)2.60042744
141sterol biosynthetic process (GO:0016126)2.59605794
142positive regulation of heart rate (GO:0010460)2.58339058
143cellular response to catecholamine stimulus (GO:0071870)2.58213841
144cellular response to monoamine stimulus (GO:0071868)2.58213841
145adhesion of symbiont to host cell (GO:0044650)2.57524073
146virion attachment to host cell (GO:0019062)2.57524073
147neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.57115755
148regulation of sarcomere organization (GO:0060297)2.57093020
149ionotropic glutamate receptor signaling pathway (GO:0035235)2.56676709
150organ growth (GO:0035265)2.56524827
151dopamine biosynthetic process (GO:0042416)2.56464466
152synaptic vesicle docking involved in exocytosis (GO:0016081)2.56356919
153positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.54879997
154positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.54814504
155regulation of muscle system process (GO:0090257)2.54045647
156regulation of voltage-gated calcium channel activity (GO:1901385)2.53832328
157peripheral nervous system development (GO:0007422)2.53339316
158cAMP catabolic process (GO:0006198)2.52532294
159auditory behavior (GO:0031223)2.51261569
160cardiac chamber formation (GO:0003207)2.51214258
161cardiac muscle cell action potential involved in contraction (GO:0086002)2.51028892
162cardiac ventricle formation (GO:0003211)2.50252777
163membrane assembly (GO:0071709)2.49761808
164regulation of potassium ion transmembrane transporter activity (GO:1901016)2.49560899
165long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.49267698
166dendrite morphogenesis (GO:0048813)2.49040159
167isoprenoid biosynthetic process (GO:0008299)2.48811829
168adult locomotory behavior (GO:0008344)2.48513451
169regulation of synaptic vesicle exocytosis (GO:2000300)2.47876934
170glycine transport (GO:0015816)2.47377011
171gamma-aminobutyric acid transport (GO:0015812)2.46830459
172enteric nervous system development (GO:0048484)2.46722916
173mechanosensory behavior (GO:0007638)2.46609119
174negative regulation of synaptic transmission (GO:0050805)2.45927061
175neurotransmitter catabolic process (GO:0042135)2.44374937
176cyclic nucleotide catabolic process (GO:0009214)2.43869968
177detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.43510982
178detection of temperature stimulus involved in sensory perception (GO:0050961)2.43510982
179positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)2.40673137
180Golgi to endosome transport (GO:0006895)2.40552141
181dendrite development (GO:0016358)2.37776686
182substrate-independent telencephalic tangential migration (GO:0021826)2.36639693
183substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.36639693
184neuron-neuron synaptic transmission (GO:0007270)2.35759904
185glycosylceramide metabolic process (GO:0006677)2.35735909
186central nervous system myelination (GO:0022010)10.2653042
187axon ensheathment in central nervous system (GO:0032291)10.2653042

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human3.66253523
2EZH2_22144423_ChIP-Seq_EOC_Human3.64086721
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.64019804
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.63318357
5* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.56658876
6EZH2_18974828_ChIP-Seq_MESCs_Mouse2.27367812
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.27367812
8TAF15_26573619_Chip-Seq_HEK293_Human2.27147995
9EZH2_27304074_Chip-Seq_ESCs_Mouse2.25259513
10* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.21700804
11RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.20365010
12SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.19822162
13SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.19532640
14SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.18522663
15* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.18268011
16EED_16625203_ChIP-ChIP_MESCs_Mouse2.11435087
17PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.10984332
18* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.06709722
19* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.99625808
20AR_21572438_ChIP-Seq_LNCaP_Human1.97632199
21* EZH2_27294783_Chip-Seq_ESCs_Mouse1.95442384
22ZFP57_27257070_Chip-Seq_ESCs_Mouse1.95350802
23VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.95005899
24* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.93694852
25* RNF2_27304074_Chip-Seq_ESCs_Mouse1.83585214
26* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.82322473
27DROSHA_22980978_ChIP-Seq_HELA_Human1.79748081
28TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.77618547
29CDX2_19796622_ChIP-Seq_MESCs_Mouse1.72326056
30CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.68044458
31ER_23166858_ChIP-Seq_MCF-7_Human1.59685402
32CBX2_27304074_Chip-Seq_ESCs_Mouse1.57897735
33PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.57290575
34* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.56911934
35* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.56312225
36CTBP1_25329375_ChIP-Seq_LNCAP_Human1.56184208
37RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.55362485
38* SMAD3_21741376_ChIP-Seq_EPCs_Human1.52963766
39CTBP2_25329375_ChIP-Seq_LNCAP_Human1.52791572
40CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.51948221
41BP1_19119308_ChIP-ChIP_Hs578T_Human1.49020918
42P300_19829295_ChIP-Seq_ESCs_Human1.48643701
43GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.48598432
44STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.47310795
45REST_21632747_ChIP-Seq_MESCs_Mouse1.46774180
46GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.43635184
47PIAS1_25552417_ChIP-Seq_VCAP_Human1.43379265
48IGF1R_20145208_ChIP-Seq_DFB_Human1.42780922
49BMI1_23680149_ChIP-Seq_NPCS_Mouse1.41928880
50SMAD4_21799915_ChIP-Seq_A2780_Human1.35159225
51* RARB_27405468_Chip-Seq_BRAIN_Mouse1.33523762
52SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.33168627
53* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.31205768
54TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.29782260
55EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.29078099
56TBX20_22080862_ChIP-Seq_HEART_Mouse1.27401874
57TBX20_22328084_ChIP-Seq_HEART_Mouse1.27401874
58ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.23712559
59* STAT3_23295773_ChIP-Seq_U87_Human1.22679919
60STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.21384876
61AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.21323874
62P53_22127205_ChIP-Seq_FIBROBLAST_Human1.20616637
63BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.20132465
64* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.19720869
65YAP1_20516196_ChIP-Seq_MESCs_Mouse1.18943164
66FUS_26573619_Chip-Seq_HEK293_Human1.18789854
67* RNF2_27304074_Chip-Seq_NSC_Mouse1.18121226
68TOP2B_26459242_ChIP-Seq_MCF-7_Human1.16510745
69CTNNB1_20460455_ChIP-Seq_HCT116_Human1.16333739
70SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.16098954
71* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.15583628
72GATA1_22025678_ChIP-Seq_K562_Human1.14978095
73SMAD_19615063_ChIP-ChIP_OVARY_Human1.12196606
74ZNF217_24962896_ChIP-Seq_MCF-7_Human1.11246638
75TP53_16413492_ChIP-PET_HCT116_Human1.11207209
76REST_18959480_ChIP-ChIP_MESCs_Mouse1.10949487
77* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.10684861
78* TCF4_23295773_ChIP-Seq_U87_Human1.09502757
79TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.09384883
80* RUNX_20019798_ChIP-Seq_JUKART_Human1.09372303
81WT1_19549856_ChIP-ChIP_CCG9911_Human1.09131324
82* VDR_22108803_ChIP-Seq_LS180_Human1.08764036
83ARNT_22903824_ChIP-Seq_MCF-7_Human1.08709487
84AHR_22903824_ChIP-Seq_MCF-7_Human1.08192236
85* NANOG_18555785_Chip-Seq_ESCs_Mouse1.08103286
86NR3C1_23031785_ChIP-Seq_PC12_Mouse1.07633405
87* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.07278321
88EP300_21415370_ChIP-Seq_HL-1_Mouse1.06858889
89* PRDM14_20953172_ChIP-Seq_ESCs_Human1.06619974
90NR3C1_21868756_ChIP-Seq_MCF10A_Human1.06139136
91NRF2_20460467_ChIP-Seq_MEFs_Mouse1.06065816
92NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.06065816
93SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.05769527
94UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.04819282
95* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.04766591
96POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.03933988
97TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03933988
98* CMYC_18555785_Chip-Seq_ESCs_Mouse1.03473760
99* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.03391038
100MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.02813851
101AR_19668381_ChIP-Seq_PC3_Human1.02669538
102SMAD3_21741376_ChIP-Seq_HESCs_Human1.02191318
103* SOX2_21211035_ChIP-Seq_LN229_Gbm1.02090581
104TAL1_26923725_Chip-Seq_HPCs_Mouse1.01546269
105LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.00824138
106LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00561047
107* RING1B_27294783_Chip-Seq_NPCs_Mouse0.99974154
108SMAD4_21741376_ChIP-Seq_HESCs_Human0.98900356
109RUNX2_22187159_ChIP-Seq_PCA_Human0.98204664
110* RING1B_27294783_Chip-Seq_ESCs_Mouse0.98021143
111* GF1_26923725_Chip-Seq_HPCs_Mouse0.97447704
112TP53_18474530_ChIP-ChIP_U2OS_Human0.96099436
113* SUZ12_18555785_Chip-Seq_ESCs_Mouse0.95646963
114* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.94127152
115MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.93568918
116AR_25329375_ChIP-Seq_VCAP_Human0.93545274
117CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.91334682
118* P300_18555785_Chip-Seq_ESCs_Mouse0.90344754
119EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.90255033
120ESR1_20079471_ChIP-ChIP_T-47D_Human0.89729387
121* E2F1_18555785_Chip-Seq_ESCs_Mouse0.89433318
122FLI1_21867929_ChIP-Seq_TH2_Mouse0.88327878
123NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.88031696
124SMAD4_21741376_ChIP-Seq_EPCs_Human0.86195565
125KDM2B_26808549_Chip-Seq_REH_Human0.86181074

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000920_abnormal_myelination4.52395838
2MP0000751_myopathy4.35395435
3MP0003880_abnormal_central_pattern4.30725468
4MP0004084_abnormal_cardiac_muscle4.11655882
5MP0003646_muscle_fatigue3.99737102
6MP0004270_analgesia3.60428318
7MP0000749_muscle_degeneration3.42555962
8MP0004215_abnormal_myocardial_fiber3.36287839
9MP0004859_abnormal_synaptic_plasticity3.32152718
10MP0004130_abnormal_muscle_cell2.96441119
11MP0003690_abnormal_glial_cell2.93189860
12MP0001486_abnormal_startle_reflex2.88141054
13MP0002837_dystrophic_cardiac_calcinosis2.75588805
14MP0004510_myositis2.66910678
15* MP0002272_abnormal_nervous_system2.64510452
16MP0004885_abnormal_endolymph2.64205299
17MP0005423_abnormal_somatic_nervous2.60955543
18* MP0002064_seizures2.59856205
19MP0003635_abnormal_synaptic_transmissio2.55559271
20MP0001905_abnormal_dopamine_level2.48974079
21MP0004087_abnormal_muscle_fiber2.45883169
22MP0005620_abnormal_muscle_contractility2.43566169
23MP0009046_muscle_twitch2.39632718
24MP0004742_abnormal_vestibular_system2.39170692
25MP0004484_altered_response_of2.34628218
26MP0001529_abnormal_vocalization2.33334152
27MP0000778_abnormal_nervous_system2.31359141
28MP0003950_abnormal_plasma_membrane2.30920649
29MP0002972_abnormal_cardiac_muscle2.29775362
30* MP0009745_abnormal_behavioral_response2.27297447
31MP0002106_abnormal_muscle_physiology2.26032706
32MP0003136_yellow_coat_color2.24476902
33MP0004142_abnormal_muscle_tone2.23555592
34MP0005330_cardiomyopathy2.21054271
35MP0003329_amyloid_beta_deposits2.18858953
36MP0005171_absent_coat_pigmentation2.17641314
37MP0005409_darkened_coat_color2.17419367
38MP0003634_abnormal_glial_cell2.06999022
39MP0001485_abnormal_pinna_reflex2.05435394
40MP0002734_abnormal_mechanical_nocicepti1.98528774
41MP0002269_muscular_atrophy1.94591162
42MP0000759_abnormal_skeletal_muscle1.94467536
43MP0006138_congestive_heart_failure1.93582921
44MP0002572_abnormal_emotion/affect_behav1.90324427
45MP0002063_abnormal_learning/memory/cond1.89595632
46MP0005369_muscle_phenotype1.86427009
47MP0002332_abnormal_exercise_endurance1.81702027
48MP0002229_neurodegeneration1.72406120
49MP0005385_cardiovascular_system_phenoty1.68024420
50MP0001544_abnormal_cardiovascular_syste1.68024420
51MP0010630_abnormal_cardiac_muscle1.65951374
52MP0002127_abnormal_cardiovascular_syste1.61936057
53MP0003632_abnormal_nervous_system1.58907802
54MP0008775_abnormal_heart_ventricle1.58109206
55MP0005623_abnormal_meninges_morphology1.57699054
56MP0002067_abnormal_sensory_capabilities1.56842035
57MP0005551_abnormal_eye_electrophysiolog1.55631355
58MP0001440_abnormal_grooming_behavior1.54774071
59MP0000955_abnormal_spinal_cord1.54323362
60MP0002882_abnormal_neuron_morphology1.52181305
61MP0008569_lethality_at_weaning1.50872878
62MP0001968_abnormal_touch/_nociception1.49647385
63MP0000750_abnormal_muscle_regeneration1.46989399
64MP0001970_abnormal_pain_threshold1.44020967
65MP0004924_abnormal_behavior1.42605921
66MP0005386_behavior/neurological_phenoty1.42605921
67MP0005410_abnormal_fertilization1.41336004
68MP0003631_nervous_system_phenotype1.41267536
69MP0002638_abnormal_pupillary_reflex1.35701993
70* MP0002066_abnormal_motor_capabilities/c1.34918861
71MP0003633_abnormal_nervous_system1.34835274
72MP0003879_abnormal_hair_cell1.34500359
73MP0000569_abnormal_digit_pigmentation1.33828089
74MP0001963_abnormal_hearing_physiology1.32128346
75MP0000462_abnormal_digestive_system1.31914689
76MP0002822_catalepsy1.26773836
77MP0005645_abnormal_hypothalamus_physiol1.26474606
78MP0002733_abnormal_thermal_nociception1.26001518
79MP0002752_abnormal_somatic_nervous1.22353038
80MP0001501_abnormal_sleep_pattern1.21902325
81MP0010678_abnormal_skin_adnexa1.21218582
82MP0001346_abnormal_lacrimal_gland1.20422534
83MP0004145_abnormal_muscle_electrophysio1.19494669
84MP0002736_abnormal_nociception_after1.14366981
85MP0004043_abnormal_pH_regulation1.13939386
86MP0001984_abnormal_olfaction1.12326855
87MP0004233_abnormal_muscle_weight1.11611877
88MP0002735_abnormal_chemical_nociception1.10744140
89MP0000383_abnormal_hair_follicle1.10385270
90MP0002184_abnormal_innervation1.09882829
91MP0004134_abnormal_chest_morphology1.09122298
92MP0002108_abnormal_muscle_morphology1.06743258
93MP0003828_pulmonary_edema1.06245826
94MP0004381_abnormal_hair_follicle1.05808575
95MP0002557_abnormal_social/conspecific_i1.04484190
96MP0003045_fibrosis1.04014723
97MP0005670_abnormal_white_adipose1.03747430
98MP0000566_synostosis1.01868838
99MP0005646_abnormal_pituitary_gland1.01039481
100MP0000604_amyloidosis1.00850788
101MP0001299_abnormal_eye_distance/1.00591725
102MP0008260_abnormal_autophagy1.00088560
103MP0001502_abnormal_circadian_rhythm0.99975342
104MP0001177_atelectasis0.99314712
105MP0001879_abnormal_lymphatic_vessel0.98226849
106MP0005195_abnormal_posterior_eye0.96829307
107MP0002152_abnormal_brain_morphology0.96213620
108MP0006276_abnormal_autonomic_nervous0.93882662
109MP0001188_hyperpigmentation0.93639706
110MP0000733_abnormal_muscle_development0.92712159
111MP0003938_abnormal_ear_development0.90400171
112MP0000026_abnormal_inner_ear0.90006886
113MP0004811_abnormal_neuron_physiology0.89311995
114MP0005666_abnormal_adipose_tissue0.87915701
115MP0005167_abnormal_blood-brain_barrier0.86136072
116MP0010368_abnormal_lymphatic_system0.85667226
117MP0000747_muscle_weakness0.83675891
118MP0005253_abnormal_eye_physiology0.82895255
119MP0000631_abnormal_neuroendocrine_gland0.79902893
120MP0006072_abnormal_retinal_apoptosis0.79066297
121MP0005165_increased_susceptibility_to0.77119951
122MP0003137_abnormal_impulse_conducting0.76631878
123MP0003122_maternal_imprinting0.71762822
124MP0003937_abnormal_limbs/digits/tail_de0.70714561
125MP0001661_extended_life_span0.69635339
126MP0001851_eye_inflammation0.68841029
127MP0009780_abnormal_chondrocyte_physiolo0.68764046
128MP0003221_abnormal_cardiomyocyte_apopto0.68164007
129MP0005451_abnormal_body_composition0.67856892
130MP0002102_abnormal_ear_morphology0.66850656
131MP0002971_abnormal_brown_adipose0.66555058
132MP0001348_abnormal_lacrimal_gland0.65466398
133MP0000230_abnormal_systemic_arterial0.65068978
134MP0001986_abnormal_taste_sensitivity0.63774538
135MP0002295_abnormal_pulmonary_circulatio0.63335915
136MP0001664_abnormal_digestion0.62498519
137MP0005266_abnormal_metabolism0.60533041
138MP0004085_abnormal_heartbeat0.60229412
139MP0004036_abnormal_muscle_relaxation0.59790954
140MP0005535_abnormal_body_temperature0.59586152
141MP0000266_abnormal_heart_morphology0.59495151
142MP0008874_decreased_physiological_sensi0.59417683
143MP0002090_abnormal_vision0.58909412
144MP0001943_abnormal_respiration0.58096065
145MP0000647_abnormal_sebaceous_gland0.56366722
146MP0003195_calcinosis0.55887758
147MP0000467_abnormal_esophagus_morphology0.55849808

Predicted human phenotypes

RankGene SetZ-score
1Sudden death (HP:0001699)6.23971782
2Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)6.20195009
3Degeneration of the lateral corticospinal tracts (HP:0002314)6.20195009
4Muscle fiber inclusion bodies (HP:0100299)6.17332155
5Bundle branch block (HP:0011710)6.13205919
6Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)5.96495756
7Nemaline bodies (HP:0003798)5.90235939
8Neurofibrillary tangles (HP:0002185)5.85356007
9Hyporeflexia of lower limbs (HP:0002600)5.46898095
10Muscle fiber splitting (HP:0003555)5.26574755
11Type 1 muscle fiber predominance (HP:0003803)5.06461761
12Abnormality of the corticospinal tract (HP:0002492)4.78804143
13Subaortic stenosis (HP:0001682)4.64541929
14Abnormality of the left ventricular outflow tract (HP:0011103)4.64541929
15Exercise-induced myalgia (HP:0003738)4.55562907
16EMG: myopathic abnormalities (HP:0003458)4.51855859
17Calf muscle hypertrophy (HP:0008981)4.47943928
18Abnormality of the calf musculature (HP:0001430)4.38901238
19Peripheral hypomyelination (HP:0007182)4.33129108
20Cerebral inclusion bodies (HP:0100314)4.18661579
21Sensory axonal neuropathy (HP:0003390)4.17550233
22Parakeratosis (HP:0001036)4.13850825
23Atrial fibrillation (HP:0005110)4.07380976
24Exercise-induced muscle cramps (HP:0003710)4.03041360
25Syncope (HP:0001279)3.95451247
26Difficulty running (HP:0009046)3.91996555
27Ventricular tachycardia (HP:0004756)3.88868627
28Supranuclear gaze palsy (HP:0000605)3.87395940
29Primary atrial arrhythmia (HP:0001692)3.76457284
30Onion bulb formation (HP:0003383)3.75900139
31EMG: neuropathic changes (HP:0003445)3.75259204
32Asymmetric septal hypertrophy (HP:0001670)3.74388374
33Myokymia (HP:0002411)3.73974347
34Heart block (HP:0012722)3.72573109
35Spastic gait (HP:0002064)3.66199950
36Supraventricular arrhythmia (HP:0005115)3.59584407
37Supraventricular tachycardia (HP:0004755)3.58260781
38Focal motor seizures (HP:0011153)3.47114361
39Ankle clonus (HP:0011448)3.46402113
40Abnormal atrioventricular conduction (HP:0005150)3.39698064
41Centrally nucleated skeletal muscle fibers (HP:0003687)3.35040780
42Intention tremor (HP:0002080)3.35028185
43Dysmetria (HP:0001310)3.31941501
44Ventricular fibrillation (HP:0001663)3.27900145
45Ventricular arrhythmia (HP:0004308)3.24636793
46Distal arthrogryposis (HP:0005684)3.23405455
47Lipoatrophy (HP:0100578)3.22979221
48Neck muscle weakness (HP:0000467)3.22022343
49Frequent falls (HP:0002359)3.09360957
50Rimmed vacuoles (HP:0003805)3.08955290
51Termporal pattern (HP:0011008)3.06154471
52Insidious onset (HP:0003587)3.06154471
53Alacrima (HP:0000522)3.03833051
54Cerebral hypomyelination (HP:0006808)2.97139219
55Dilated cardiomyopathy (HP:0001644)2.96524797
56Retinal dysplasia (HP:0007973)2.92880806
57Distal lower limb muscle weakness (HP:0009053)2.92397452
58Scanning speech (HP:0002168)2.86630878
59Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.84621110
60Abnormality of the foot musculature (HP:0001436)2.83935697
61Abnormal auditory evoked potentials (HP:0006958)2.81476357
62Febrile seizures (HP:0002373)2.78819150
63Increased circulating renin level (HP:0000848)2.77786696
64Areflexia of lower limbs (HP:0002522)2.76604013
65Prolonged QT interval (HP:0001657)2.71757923
66Hemiplegia (HP:0002301)2.69741343
67Abnormality of skeletal muscle fiber size (HP:0012084)2.69537964
68Atrioventricular block (HP:0001678)2.64911642
69Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.64753001
70Slow saccadic eye movements (HP:0000514)2.62532521
71Metabolic alkalosis (HP:0200114)2.62444461
72Dysmetric saccades (HP:0000641)2.61928116
73Increased variability in muscle fiber diameter (HP:0003557)2.61909816
74Clumsiness (HP:0002312)2.60898748
75Pheochromocytoma (HP:0002666)2.57349513
76Myoglobinuria (HP:0002913)2.57087229
77Myotonia (HP:0002486)2.52892052
78Atonic seizures (HP:0010819)2.49161695
79Limb dystonia (HP:0002451)2.49062623
80Generalized muscle weakness (HP:0003324)2.47831619
81Focal seizures (HP:0007359)2.47579462
82Abnormal EKG (HP:0003115)2.46285296
83Cerebral hemorrhage (HP:0001342)2.46127559
84Akinesia (HP:0002304)2.45622516
85Lower limb muscle weakness (HP:0007340)2.44601850
86Absent septum pellucidum (HP:0001331)2.42577706
87Thickened helices (HP:0000391)2.42562635
88Decreased lacrimation (HP:0000633)2.41612797
89Autoamputation (HP:0001218)2.41528797
90Aplasia involving bones of the extremities (HP:0009825)2.41352810
91Aplasia involving bones of the upper limbs (HP:0009823)2.41352810
92Aplasia of the phalanges of the hand (HP:0009802)2.41352810
93Rhabdomyolysis (HP:0003201)2.40924820
94Postural instability (HP:0002172)2.38832252
95Anteriorly placed anus (HP:0001545)2.37311678
96Increased connective tissue (HP:0009025)2.36186126
97Action tremor (HP:0002345)2.34515157
98Round ear (HP:0100830)2.34437335
99Epileptic encephalopathy (HP:0200134)2.33115443
100Myopathic facies (HP:0002058)2.32351327
101Segmental peripheral demyelination/remyelination (HP:0003481)2.28277533
102Left ventricular hypertrophy (HP:0001712)2.27329850
103Leukodystrophy (HP:0002415)2.27285474
104Neuroendocrine neoplasm (HP:0100634)2.20765300
105Premature skin wrinkling (HP:0100678)2.18652238
106Morphological abnormality of the inner ear (HP:0011390)2.18285234
107Hypoplasia of the iris (HP:0007676)2.18182495
108Hypomagnesemia (HP:0002917)2.17157442
109Split foot (HP:0001839)2.17044902
110Hypokalemic alkalosis (HP:0001949)2.15209155
111Hypoplastic pelvis (HP:0008839)2.12197323
112Broad-based gait (HP:0002136)2.09318813
113Scapular winging (HP:0003691)2.05745484
114Abnormality of the septum pellucidum (HP:0007375)2.05553826
115Dysdiadochokinesis (HP:0002075)2.03650461
116Coronal craniosynostosis (HP:0004440)2.03004342
117White forelock (HP:0002211)2.01076944
118Dialeptic seizures (HP:0011146)2.00562772
119Fetal akinesia sequence (HP:0001989)2.00075125
120Clonus (HP:0002169)1.98953454
121Hyperventilation (HP:0002883)1.98715913
122Synostosis involving the elbow (HP:0003938)1.98373819
123Humeroradial synostosis (HP:0003041)1.98373819
124CNS hypomyelination (HP:0003429)1.97386303
125Generalized tonic-clonic seizures (HP:0002069)1.96693553
126Urinary urgency (HP:0000012)1.95766043
127Megalencephaly (HP:0001355)1.92339010
128Patchy hypopigmentation of hair (HP:0011365)1.91975608
129Papillary thyroid carcinoma (HP:0002895)1.91530971
130Ulnar deviation of the wrist (HP:0003049)1.90223847
131Stridor (HP:0010307)1.89804642
132Lower limb amyotrophy (HP:0007210)1.89059176
133Muscular dystrophy (HP:0003560)1.88889067
134Hammertoe (HP:0001765)1.88303338
135Diplopia (HP:0000651)1.88135368
136Abnormality of binocular vision (HP:0011514)1.88135368
137Steppage gait (HP:0003376)1.87195391
138Generalized myoclonic seizures (HP:0002123)1.87180475
139Foot dorsiflexor weakness (HP:0009027)1.86929152
140Hyperkalemia (HP:0002153)1.85660032
141Progressive cerebellar ataxia (HP:0002073)1.85612423
142Morphological abnormality of the pyramidal tract (HP:0002062)1.84957905
143Decreased motor nerve conduction velocity (HP:0003431)1.84635648
144Septo-optic dysplasia (HP:0100842)1.83843543
145Progressive inability to walk (HP:0002505)1.83816509
146Partial duplication of thumb phalanx (HP:0009944)1.83721430
147Gaze-evoked nystagmus (HP:0000640)1.83628370
148Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.83551040
149Bowel incontinence (HP:0002607)1.83492094
150Congenital ichthyosiform erythroderma (HP:0007431)1.83348509
151Absence seizures (HP:0002121)1.82746476
152Hip contracture (HP:0003273)1.82699400
153Abnormality of the phalanges of the 2nd finger (HP:0009541)1.82556348
154Widely spaced teeth (HP:0000687)1.82239468
155Vaginal atresia (HP:0000148)1.82040252
156Muscle hypertrophy of the lower extremities (HP:0008968)1.82032585
157Cupped ear (HP:0000378)1.81049492
158Esophageal atresia (HP:0002032)1.80883627
159Dynein arm defect of respiratory motile cilia (HP:0012255)1.80569757
160Absent/shortened dynein arms (HP:0200106)1.80569757
161Truncal ataxia (HP:0002078)1.80426660
162Rapidly progressive (HP:0003678)1.80424798
163Spastic tetraparesis (HP:0001285)1.80213357
164Infantile muscular hypotonia (HP:0008947)1.80002020
165Urinary bladder sphincter dysfunction (HP:0002839)1.79940972
166Difficulty climbing stairs (HP:0003551)1.79688317
167Type II lissencephaly (HP:0007260)1.77398184
168Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.77144902
169Hemiparesis (HP:0001269)1.76485122
170Anomalous pulmonary venous return (HP:0010772)1.75340819
171Genital tract atresia (HP:0001827)1.75143475
172Distal lower limb amyotrophy (HP:0008944)1.74341707
173Gowers sign (HP:0003391)1.73735885
174Right ventricular cardiomyopathy (HP:0011663)1.73448912
175Bulbar palsy (HP:0001283)1.73277831
176Absent phalangeal crease (HP:0006109)1.73225960
177Mildly elevated creatine phosphokinase (HP:0008180)1.71586838
178Papilledema (HP:0001085)1.70378403

Predicted kinase interactions (KEA)

RankGene SetZ-score
1OBSCN6.08691355
2STK395.79926529
3OXSR14.46572290
4TTN3.47945401
5EPHB13.20033436
6PKN12.58828894
7CDK192.49553699
8TNIK2.38497189
9MAPKAPK52.30490281
10WNK42.30312436
11BCR2.24962519
12DMPK2.16352447
13MAPK122.11928073
14WNK11.94882176
15PNCK1.92476752
16CASK1.86126462
17FGFR21.79788373
18SGK21.77108236
19EPHA41.74033972
20UHMK11.73031731
21NTRK11.72809248
22CSNK1G31.70105241
23MARK11.68119542
24PAK61.61745144
25NEK61.60327179
26MAP3K71.57009609
27PBK1.51700612
28CSNK1A1L1.51272026
29PRPF4B1.44870496
30MET1.44402058
31CAMK2B1.41115146
32ICK1.39870122
33CSNK1G21.38260588
34MYLK1.37889532
35CSNK1G11.33878939
36PIK3CG1.33675555
37SGK2231.32462943
38SGK4941.32462943
39ROCK21.32176472
40CLK11.31227069
41SGK31.31082152
42TESK21.29273157
43FGR1.25386288
44CAMK41.23388356
45LIMK11.23330034
46NTRK31.21893943
47CAMK2D1.19557724
48TIE11.15651086
49RIPK11.12903689
50MAPK131.11711363
51IRAK21.09485248
52CDK51.07511825
53EPHA31.05925884
54PAK31.01945898
55CAMKK21.01183258
56MUSK1.00801806
57NLK0.99735888
58PDK20.99274748
59TYRO30.98056323
60CAMK2A0.97171145
61MARK20.95709487
62NTRK20.95663929
63TRPM70.93600798
64FES0.93099520
65KSR10.92981515
66CAMKK10.91642967
67BMPR1B0.91098526
68CAMK2G0.90581834
69CDK140.85073461
70MAP3K130.84335172
71PHKG20.81967918
72PHKG10.81967918
73PRKCQ0.81807667
74RAF10.78469907
75PRKCE0.77575253
76DYRK20.77558248
77MAP2K40.76899129
78CDK150.76179447
79RIPK40.74904214
80RET0.74336460
81CAMK1G0.73201455
82PRKAA10.73149438
83STK110.72489757
84CDK180.72211612
85MOS0.70645561
86MAPK150.70041383
87PDPK10.68649939
88CDK11A0.68167963
89MAP3K90.66449058
90PRKD10.64798308
91ZAP700.64556493
92PRKAA20.63929754
93FYN0.62955272
94MAPK40.60790719
95ARAF0.59901289
96RPS6KA30.58654883
97MINK10.58337187
98PRKCH0.57837654
99BLK0.57300697
100MAP2K70.55561950
101PINK10.54995763
102NEK90.54772989
103LATS20.54543911
104MAP2K30.53256091
105GRK70.53127383
106MAP3K40.51415290
107JAK20.51322225
108PRKD30.50849804
109MAP3K20.49807680
110PRKG10.49083518
111ADRBK20.48555879
112ERBB40.46473217
113IRAK10.45097846
114MST40.44505587
115BMPR20.44222371
116PDK10.43530445
117PLK20.43131546
118CSNK1A10.42773452
119CSNK1D0.42558694
120MAP2K10.42410049
121FGFR30.42227154
122PIK3CA0.42144748
123* PRKACA0.41508864
124PTK2B0.41298317
125MAP3K10.41152891
126JAK10.40410479
127PDGFRB0.40242560
128CCNB10.40104087
129STK380.38908284
130SGK10.37702121
131PRKACB0.37411462
132GRK50.36102830
133MAPKAPK30.35319072
134GSK3A0.35088512
135RPS6KA50.34132680
136DAPK20.33724284
137WNK30.33603341
138KSR20.33386213
139CAMK10.32406642
140MAPK70.32300891
141ROCK10.30883702
142DYRK1A0.30656638
143MAPK100.29649728

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009003.77026420
2Steroid biosynthesis_Homo sapiens_hsa001003.11308849
3Fatty acid elongation_Homo sapiens_hsa000622.98915365
4Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.77147652
5Ether lipid metabolism_Homo sapiens_hsa005652.66776350
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.36455609
7Axon guidance_Homo sapiens_hsa043602.04224359
8Glutamatergic synapse_Homo sapiens_hsa047242.03420414
9Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.02374908
10* GABAergic synapse_Homo sapiens_hsa047271.95533889
11Nicotine addiction_Homo sapiens_hsa050331.91477731
12Serotonergic synapse_Homo sapiens_hsa047261.89015234
13Morphine addiction_Homo sapiens_hsa050321.83514847
14Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.82819948
15Circadian rhythm_Homo sapiens_hsa047101.72296103
16Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.56477396
17Circadian entrainment_Homo sapiens_hsa047131.56449769
18Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.55340948
19Long-term depression_Homo sapiens_hsa047301.52833288
20Sphingolipid metabolism_Homo sapiens_hsa006001.49868328
21Synaptic vesicle cycle_Homo sapiens_hsa047211.48335143
22Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.46164689
23Cocaine addiction_Homo sapiens_hsa050301.43803908
24Salivary secretion_Homo sapiens_hsa049701.39909338
25Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.37400612
26Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.36210957
27Dopaminergic synapse_Homo sapiens_hsa047281.30327566
28Cholinergic synapse_Homo sapiens_hsa047251.27419409
29Gastric acid secretion_Homo sapiens_hsa049711.26556625
30Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.20165504
31Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.18995484
32Collecting duct acid secretion_Homo sapiens_hsa049661.17414424
33Renin secretion_Homo sapiens_hsa049241.16782315
34Renal cell carcinoma_Homo sapiens_hsa052111.15428055
35Nitrogen metabolism_Homo sapiens_hsa009101.15417752
36Phototransduction_Homo sapiens_hsa047441.15243758
37SNARE interactions in vesicular transport_Homo sapiens_hsa041301.13477738
38Oxidative phosphorylation_Homo sapiens_hsa001901.11594071
39Linoleic acid metabolism_Homo sapiens_hsa005911.10322299
40Estrogen signaling pathway_Homo sapiens_hsa049151.08406853
41Vascular smooth muscle contraction_Homo sapiens_hsa042701.08187901
42Amphetamine addiction_Homo sapiens_hsa050311.07567632
43Olfactory transduction_Homo sapiens_hsa047401.07299268
44Insulin signaling pathway_Homo sapiens_hsa049101.07020091
45Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.03599334
46alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.02919283
47Thyroid hormone signaling pathway_Homo sapiens_hsa049191.02433823
48Sphingolipid signaling pathway_Homo sapiens_hsa040711.01894714
49Glioma_Homo sapiens_hsa052141.00140706
50Vibrio cholerae infection_Homo sapiens_hsa051100.99415388
51Histidine metabolism_Homo sapiens_hsa003400.98926909
52Phospholipase D signaling pathway_Homo sapiens_hsa040720.98629019
53Dorso-ventral axis formation_Homo sapiens_hsa043200.97016554
54Taste transduction_Homo sapiens_hsa047420.96692695
55Long-term potentiation_Homo sapiens_hsa047200.95406009
56Autoimmune thyroid disease_Homo sapiens_hsa053200.95255882
57Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.94163527
58Ras signaling pathway_Homo sapiens_hsa040140.94116279
59Endometrial cancer_Homo sapiens_hsa052130.94005645
60Sulfur metabolism_Homo sapiens_hsa009200.93110014
61Platelet activation_Homo sapiens_hsa046110.92262543
62Type II diabetes mellitus_Homo sapiens_hsa049300.91107512
63ErbB signaling pathway_Homo sapiens_hsa040120.90235034
64VEGF signaling pathway_Homo sapiens_hsa043700.90231244
65Alzheimers disease_Homo sapiens_hsa050100.89318483
66Gap junction_Homo sapiens_hsa045400.87978105
67Vitamin B6 metabolism_Homo sapiens_hsa007500.86944357
68Oxytocin signaling pathway_Homo sapiens_hsa049210.86890128
69Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.86509263
70Ovarian steroidogenesis_Homo sapiens_hsa049130.85986534
71Inositol phosphate metabolism_Homo sapiens_hsa005620.85417278
72Rheumatoid arthritis_Homo sapiens_hsa053230.85363162
73Neurotrophin signaling pathway_Homo sapiens_hsa047220.84793998
74mTOR signaling pathway_Homo sapiens_hsa041500.83892418
75Focal adhesion_Homo sapiens_hsa045100.82653715
76Glucagon signaling pathway_Homo sapiens_hsa049220.81987068
77Cardiac muscle contraction_Homo sapiens_hsa042600.81703146
78Pancreatic secretion_Homo sapiens_hsa049720.81341387
79Insulin secretion_Homo sapiens_hsa049110.81046995
80cAMP signaling pathway_Homo sapiens_hsa040240.80991660
81Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.80965155
82Protein export_Homo sapiens_hsa030600.80293882
83Endocytosis_Homo sapiens_hsa041440.80182818
84Longevity regulating pathway - mammal_Homo sapiens_hsa042110.79940677
85Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.79912221
86Tight junction_Homo sapiens_hsa045300.79911815
87Butanoate metabolism_Homo sapiens_hsa006500.79874991
88Calcium signaling pathway_Homo sapiens_hsa040200.78993086
89Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.78864703
90Insulin resistance_Homo sapiens_hsa049310.77326270
91Parkinsons disease_Homo sapiens_hsa050120.76119024
92FoxO signaling pathway_Homo sapiens_hsa040680.75181933
93Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.74001104
94Adipocytokine signaling pathway_Homo sapiens_hsa049200.73350900
95AMPK signaling pathway_Homo sapiens_hsa041520.72305719
96Bile secretion_Homo sapiens_hsa049760.71859820
97Carbohydrate digestion and absorption_Homo sapiens_hsa049730.69314248
98Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.66133042
99Aldosterone synthesis and secretion_Homo sapiens_hsa049250.65198740
100Non-small cell lung cancer_Homo sapiens_hsa052230.63873502
101Choline metabolism in cancer_Homo sapiens_hsa052310.62627961
102Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.61158593
103Phosphatidylinositol signaling system_Homo sapiens_hsa040700.60952371
104AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.60279026
105GnRH signaling pathway_Homo sapiens_hsa049120.60211531
106Adherens junction_Homo sapiens_hsa045200.59774894
107MAPK signaling pathway_Homo sapiens_hsa040100.59285159
108Prolactin signaling pathway_Homo sapiens_hsa049170.59033447
109Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.57719140
110Glycerophospholipid metabolism_Homo sapiens_hsa005640.57279844
111Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.56026264
112Dilated cardiomyopathy_Homo sapiens_hsa054140.55821364
1132-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.55594624
114ABC transporters_Homo sapiens_hsa020100.55120903
115Arachidonic acid metabolism_Homo sapiens_hsa005900.55045117
116Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.54751459
117Regulation of actin cytoskeleton_Homo sapiens_hsa048100.54405377
118T cell receptor signaling pathway_Homo sapiens_hsa046600.54158905
119Arginine and proline metabolism_Homo sapiens_hsa003300.52648424
120Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.51865710
121cGMP-PKG signaling pathway_Homo sapiens_hsa040220.51033463
122Lysosome_Homo sapiens_hsa041420.50328606
123Chemokine signaling pathway_Homo sapiens_hsa040620.49319782
124Hedgehog signaling pathway_Homo sapiens_hsa043400.48587018
125Melanogenesis_Homo sapiens_hsa049160.48184166
126Phagosome_Homo sapiens_hsa041450.47387198
127Amoebiasis_Homo sapiens_hsa051460.47261350
128Oocyte meiosis_Homo sapiens_hsa041140.47156767
129Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.46810692
130HIF-1 signaling pathway_Homo sapiens_hsa040660.45966026
131Osteoclast differentiation_Homo sapiens_hsa043800.45651867
132Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.45642201
133Mineral absorption_Homo sapiens_hsa049780.44385821
134Thyroid hormone synthesis_Homo sapiens_hsa049180.43373946
135Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.43303447
136B cell receptor signaling pathway_Homo sapiens_hsa046620.42195715
137Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.39564023
138Rap1 signaling pathway_Homo sapiens_hsa040150.39388898
139ECM-receptor interaction_Homo sapiens_hsa045120.36792151
140African trypanosomiasis_Homo sapiens_hsa051430.36276754
141Prion diseases_Homo sapiens_hsa050200.35841560
142Fatty acid biosynthesis_Homo sapiens_hsa000610.34244058

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