PLCL2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of leukocyte mediated cytotoxicity (GO:0001911)6.70257122
2negative regulation of cell killing (GO:0031342)6.70257122
3positive regulation of gamma-delta T cell activation (GO:0046645)4.70658928
4detection of other organism (GO:0098543)4.07606604
5antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.05939141
6positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.87762890
7detection of bacterium (GO:0016045)3.84950220
8antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.78716322
9antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.78716322
10negative regulation of lymphocyte mediated immunity (GO:0002707)3.77547427
11locomotory exploration behavior (GO:0035641)3.74590881
12regulation of gamma-delta T cell differentiation (GO:0045586)3.69566891
13antigen processing and presentation of endogenous antigen (GO:0019883)3.66905009
14regulation of alpha-beta T cell proliferation (GO:0046640)3.63803306
15positive regulation of granulocyte differentiation (GO:0030854)3.62267795
16synaptic vesicle maturation (GO:0016188)3.60592158
17negative regulation of T cell mediated immunity (GO:0002710)3.59224339
18regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.59064646
19activated T cell proliferation (GO:0050798)3.54496148
20neutrophil activation involved in immune response (GO:0002283)3.53042232
21* regulation of B cell receptor signaling pathway (GO:0050855)3.51435345
22negative thymic T cell selection (GO:0045060)3.45437617
23regulation of ARF protein signal transduction (GO:0032012)3.44085801
24regulation of gamma-delta T cell activation (GO:0046643)3.43729463
25B cell receptor signaling pathway (GO:0050853)3.41398776
26antigen processing and presentation via MHC class Ib (GO:0002475)3.41241250
27G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.40417673
28detection of external biotic stimulus (GO:0098581)3.40395940
29negative T cell selection (GO:0043383)3.37178177
30interferon-gamma production (GO:0032609)3.36508524
31regulation of short-term neuronal synaptic plasticity (GO:0048172)3.32514387
32macrophage activation (GO:0042116)3.29278519
33positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.28543588
34positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.23989318
35negative regulation of leukocyte mediated immunity (GO:0002704)3.22703094
36detection of molecule of bacterial origin (GO:0032490)3.20378074
37production of molecular mediator involved in inflammatory response (GO:0002532)3.19840632
38positive thymic T cell selection (GO:0045059)3.19635547
39positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.16977130
40positive T cell selection (GO:0043368)3.16865491
41response to interleukin-15 (GO:0070672)3.16056237
42phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.15201259
43* B cell proliferation (GO:0042100)3.11758289
44respiratory burst (GO:0045730)3.10684599
45positive regulation of Rap GTPase activity (GO:0032854)3.09249372
46negative regulation of B cell proliferation (GO:0030889)3.07803545
47positive regulation of interferon-alpha production (GO:0032727)3.07102142
48modulation by symbiont of host immune response (GO:0052553)3.06322226
49positive regulation by symbiont of host defense response (GO:0052509)3.06322226
50modulation by symbiont of host defense response (GO:0052031)3.06322226
51modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.06322226
52modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.06322226
53positive regulation by organism of defense response of other organism involved in symbiotic interact3.06322226
54negative regulation of interleukin-12 production (GO:0032695)3.05185021
55neutrophil mediated immunity (GO:0002446)3.03164909
56I-kappaB phosphorylation (GO:0007252)3.01704205
57macrophage activation involved in immune response (GO:0002281)3.00098016
58regulation of Rap GTPase activity (GO:0032317)2.99581081
59regulation of interleukin-12 biosynthetic process (GO:0045075)2.97906046
60T cell selection (GO:0045058)2.96535064
61B cell homeostasis (GO:0001782)2.96007704
62regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.95184639
63regulation of glutamate receptor signaling pathway (GO:1900449)2.91768612
64detection of biotic stimulus (GO:0009595)2.91665900
65positive regulation of B cell differentiation (GO:0045579)2.90277405
66positive regulation of alpha-beta T cell proliferation (GO:0046641)2.90044914
67synaptic vesicle exocytosis (GO:0016079)2.89514263
68immunoglobulin mediated immune response (GO:0016064)2.87617904
69regulation of synapse structural plasticity (GO:0051823)2.85083176
70regulation of ARF GTPase activity (GO:0032312)2.84600728
71regulation of interferon-alpha production (GO:0032647)2.83857733
72negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.83630412
73regulation of synaptic vesicle exocytosis (GO:2000300)2.83338607
74negative regulation of erythrocyte differentiation (GO:0045647)2.83136403
75defense response to protozoan (GO:0042832)2.82180064
76type I interferon signaling pathway (GO:0060337)2.81077725
77cellular response to type I interferon (GO:0071357)2.81077725
78thymic T cell selection (GO:0045061)2.81024355
79response to type I interferon (GO:0034340)2.78832596
80negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.78716637
81myeloid leukocyte mediated immunity (GO:0002444)2.78656242
82regulation of B cell proliferation (GO:0030888)2.76907482
83regulation of interferon-beta biosynthetic process (GO:0045357)2.74275636
84activation of protein kinase A activity (GO:0034199)2.73283679
85response to peptidoglycan (GO:0032494)2.73138712
86cellular response to interleukin-15 (GO:0071350)2.72029924
87regulation of necroptotic process (GO:0060544)2.71316608
88adenosine receptor signaling pathway (GO:0001973)2.69984083
89negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.69962334
90regulation of granulocyte differentiation (GO:0030852)2.69668539
91T cell receptor signaling pathway (GO:0050852)2.67957949
92histone H3-K36 demethylation (GO:0070544)2.66949407
93hepatocyte apoptotic process (GO:0097284)2.64879599
94nerve growth factor signaling pathway (GO:0038180)2.64370285
95positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.62836239
96T cell migration (GO:0072678)2.62731376
97T cell homeostasis (GO:0043029)2.62496927
98regulation of natural killer cell mediated immunity (GO:0002715)2.62385927
99regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.62385927
100positive regulation of B cell proliferation (GO:0030890)2.62248532
101positive regulation of B cell activation (GO:0050871)2.62192486
102JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.62101390
103regulation of B cell differentiation (GO:0045577)2.61274912
104positive regulation of mast cell activation (GO:0033005)2.61260918
105NIK/NF-kappaB signaling (GO:0038061)2.59690734
106myeloid dendritic cell differentiation (GO:0043011)2.57016170
107regulation of synaptic vesicle transport (GO:1902803)2.55980711
108regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.54355741
109ionotropic glutamate receptor signaling pathway (GO:0035235)2.52485374
110natural killer cell differentiation (GO:0001779)2.50787357
111prepulse inhibition (GO:0060134)2.49330321
112myeloid cell activation involved in immune response (GO:0002275)2.48703531
113adaptation of signaling pathway (GO:0023058)2.46712636
114clathrin coat assembly (GO:0048268)2.46608193
115vocalization behavior (GO:0071625)2.46563452
116regulation of long-term neuronal synaptic plasticity (GO:0048169)2.46144490
117exploration behavior (GO:0035640)2.45655257
118interferon-gamma-mediated signaling pathway (GO:0060333)2.45313323
119germinal center formation (GO:0002467)2.45105687
120myeloid dendritic cell activation (GO:0001773)2.44806944
121regulation of T cell tolerance induction (GO:0002664)2.44157156
122tolerance induction (GO:0002507)2.43388522
123sodium ion export (GO:0071436)2.37828292
124synaptic vesicle docking involved in exocytosis (GO:0016081)2.37147643
125glutamate secretion (GO:0014047)2.36388339
126layer formation in cerebral cortex (GO:0021819)2.34559857
127vesicle transport along microtubule (GO:0047496)2.32947612
128signal complex assembly (GO:0007172)2.31942662
129response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.30750440
130response to host immune response (GO:0052572)2.30750440
131mast cell degranulation (GO:0043303)2.29853336
132mast cell activation involved in immune response (GO:0002279)2.29853336
133* regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.29171624
134T cell costimulation (GO:0031295)2.28771491
135regulation of excitatory postsynaptic membrane potential (GO:0060079)2.28588386
136response to host (GO:0075136)2.28573565
137response to host defenses (GO:0052200)2.28573565
138response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.28573565
139positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.28366594
140membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.28246272
141antigen receptor-mediated signaling pathway (GO:0050851)2.28090322
142regulation of beta-amyloid formation (GO:1902003)2.27080638
143peptidyl-threonine phosphorylation (GO:0018107)2.27068609
144neurotransmitter secretion (GO:0007269)2.26810292
145regulation of neuronal synaptic plasticity (GO:0048168)2.25941946
146leukocyte aggregation (GO:0070486)2.24793137
147neutrophil activation (GO:0042119)2.24505282
148lymphocyte costimulation (GO:0031294)2.23796517
149cellular response to zinc ion (GO:0071294)2.21618299
150microglial cell activation (GO:0001774)2.20488447
151cellular extravasation (GO:0045123)2.19738649

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.19292096
2IRF8_22096565_ChIP-ChIP_GC-B_Human3.60903881
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.37583053
4IRF8_21731497_ChIP-ChIP_J774_Mouse3.06120302
5NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.85222309
6* IRF8_27001747_Chip-Seq_BMDM_Mouse2.71362838
7SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.61433444
8* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.57202820
9VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.54211327
10* STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.39737517
11RARB_27405468_Chip-Seq_BRAIN_Mouse2.34475540
12IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.33904777
13EGR1_19374776_ChIP-ChIP_THP-1_Human2.32820511
14RUNX_20019798_ChIP-Seq_JUKART_Human2.28855226
15* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.28500793
16MYC_22102868_ChIP-Seq_BL_Human2.23513231
17NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.20258644
18TCF7_22412390_ChIP-Seq_EML_Mouse2.15653106
19SPI1_23127762_ChIP-Seq_K562_Human2.12938092
20IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.11891031
21EZH2_22144423_ChIP-Seq_EOC_Human2.07895936
22GATA1_22025678_ChIP-Seq_K562_Human2.02794309
23KDM2B_26808549_Chip-Seq_SUP-B15_Human1.98778333
24SMAD_19615063_ChIP-ChIP_OVARY_Human1.97628814
25KDM2B_26808549_Chip-Seq_DND41_Human1.96943009
26BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.94185251
27VDR_21846776_ChIP-Seq_THP-1_Human1.92056176
28DROSHA_22980978_ChIP-Seq_HELA_Human1.90720452
29* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.88871081
30KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.88138327
31IKZF1_21737484_ChIP-ChIP_HCT116_Human1.85281768
32* MYB_21317192_ChIP-Seq_ERMYB_Mouse1.82541094
33MAF_26560356_Chip-Seq_TH1_Human1.80757401
34SCL_19346495_ChIP-Seq_HPC-7_Human1.78752325
35BP1_19119308_ChIP-ChIP_Hs578T_Human1.70937422
36GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.70480324
37* MYB_26560356_Chip-Seq_TH2_Human1.69956528
38Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.64636077
39FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.64395805
40KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.60558741
41VDR_24763502_ChIP-Seq_THP-1_Human1.59122415
42MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.58107935
43STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.57350862
44BRD4_27068464_Chip-Seq_AML-cells_Mouse1.56465328
45STAT4_19710469_ChIP-ChIP_TH1__Mouse1.55161246
46EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.53957710
47SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.52313350
48UTX_26944678_Chip-Seq_JUKART_Human1.49407075
49GATA1_19941827_ChIP-Seq_MEL_Mouse1.46963748
50MYB_26560356_Chip-Seq_TH1_Human1.46635260
51PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.46550116
52REST_21632747_ChIP-Seq_MESCs_Mouse1.41286875
53KDM2B_26808549_Chip-Seq_JURKAT_Human1.40625313
54NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.37405689
55GATA3_27048872_Chip-Seq_THYMUS_Human1.35895257
56* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.34728995
57THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.32879917
58VDR_24787735_ChIP-Seq_THP-1_Human1.30792689
59GATA1_19941826_ChIP-Seq_K562_Human1.30743567
60SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.28997707
61KDM2B_26808549_Chip-Seq_K562_Human1.27726130
62* RUNX1_22412390_ChIP-Seq_EML_Mouse1.27635716
63RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.25368424
64* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.24700140
65NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.20230041
66CDX2_19796622_ChIP-Seq_MESCs_Mouse1.16498755
67LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.16074367
68REST_18959480_ChIP-ChIP_MESCs_Mouse1.14694896
69EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.14356709
70RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.11747040
71PU_27001747_Chip-Seq_BMDM_Mouse1.10959645
72TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.10656162
73GATA2_19941826_ChIP-Seq_K562_Human1.09381842
74PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.09279039
75GATA2_22383799_ChIP-Seq_G1ME_Mouse1.07891343
76* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.07280914
77CIITA_25753668_ChIP-Seq_RAJI_Human1.06615211
78AR_21572438_ChIP-Seq_LNCaP_Human1.05459212
79IGF1R_20145208_ChIP-Seq_DFB_Human1.05050541
80DNAJC2_21179169_ChIP-ChIP_NT2_Human1.04866090
81LXR_22292898_ChIP-Seq_THP-1_Human1.04463945
82* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.01749829
83RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.98597177
84* TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.98532358
85CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.98210324
86MAF_26560356_Chip-Seq_TH2_Human0.98150631
87* DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.97679403
88* SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.97444525
89* NR3C1_23031785_ChIP-Seq_PC12_Mouse0.96882187
90SPI1_23547873_ChIP-Seq_NB4_Human0.96447076
91KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.95678333
92* PRDM14_20953172_ChIP-Seq_ESCs_Human0.94644459
93GATA3_26560356_Chip-Seq_TH2_Human0.92381715
94ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.91466447
95* SMRT_27268052_Chip-Seq_Bcells_Human0.91022391
96* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.90491575
97ELF1_17652178_ChIP-ChIP_JURKAT_Human0.90045018
98* SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.89729575
99WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.89075818
100CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.88840060
101RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.87750250
102CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.87438320
103* JARID2_20064375_ChIP-Seq_MESCs_Mouse0.87251983
104GATA1_19941827_ChIP-Seq_MEL86_Mouse0.86957415
105GATA3_26560356_Chip-Seq_TH1_Human0.84690496
106* SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.84110473
107RXR_22108803_ChIP-Seq_LS180_Human0.83798274
108LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.83504539
109FLI1_27457419_Chip-Seq_LIVER_Mouse0.82598572
110PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.80250554
111SOX2_21211035_ChIP-Seq_LN229_Gbm0.80040511
112WT1_25993318_ChIP-Seq_PODOCYTE_Human0.79315325
113* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.78831285
114POU3F2_20337985_ChIP-ChIP_501MEL_Human0.78780300
115ELK3_25401928_ChIP-Seq_HUVEC_Human0.78706534
116OCT4_21477851_ChIP-Seq_ESCs_Mouse0.78196762
117EGR1_19032775_ChIP-ChIP_M12_Human0.77818158
118ZFP281_27345836_Chip-Seq_ESCs_Mouse0.77158750
119GATA2_21666600_ChIP-Seq_HMVEC_Human0.77090831
120NOTCH1_21737748_ChIP-Seq_TLL_Human0.76722882
121* TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.76324406
122GATA1_22383799_ChIP-Seq_G1ME_Mouse0.71002984
123EZH2_27294783_Chip-Seq_NPCs_Mouse0.69621845
124BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.68044596
125SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.67499043
126CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.67324138
127GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.66739670
128FLI1_21867929_ChIP-Seq_TH2_Mouse0.65720874
129POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.64796343
130TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.64796343
131ETS1_22383799_ChIP-Seq_G1ME_Mouse0.63969414
132VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.63002790

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.25340279
2MP0003303_peritoneal_inflammation3.55229461
3MP0003724_increased_susceptibility_to3.31037361
4MP0000569_abnormal_digit_pigmentation3.13447123
5MP0004510_myositis3.00246223
6MP0001835_abnormal_antigen_presentation2.86854511
7MP0002822_catalepsy2.52128258
8MP0008057_abnormal_DNA_replication2.51354148
9MP0005671_abnormal_response_to2.39200877
10MP0002009_preneoplasia2.37974765
11MP0000685_abnormal_immune_system2.36025053
12MP0003300_gastrointestinal_ulcer2.31455820
13* MP0001800_abnormal_humoral_immune2.30488047
14MP0003635_abnormal_synaptic_transmissio2.28932321
15MP0005387_immune_system_phenotype2.25529159
16MP0001790_abnormal_immune_system2.25529159
17MP0003172_abnormal_lysosome_physiology2.19135581
18MP0003436_decreased_susceptibility_to2.10242081
19* MP0005000_abnormal_immune_tolerance2.04235565
20* MP0002452_abnormal_antigen_presenting1.99892657
21* MP0002723_abnormal_immune_serum1.95888964
22MP0003828_pulmonary_edema1.95548116
23* MP0001819_abnormal_immune_cell1.90056011
24* MP0002420_abnormal_adaptive_immunity1.89014970
25MP0002166_altered_tumor_susceptibility1.88505946
26MP0009745_abnormal_behavioral_response1.88169527
27MP0002909_abnormal_adrenal_gland1.87348032
28MP0002063_abnormal_learning/memory/cond1.86920380
29MP0003183_abnormal_peptide_metabolism1.85455325
30MP0002419_abnormal_innate_immunity1.84712294
31MP0005464_abnormal_platelet_physiology1.80562701
32MP0003646_muscle_fatigue1.75047681
33MP0003075_altered_response_to1.74126565
34MP0002064_seizures1.69500915
35MP0008961_abnormal_basal_metabolism1.66933955
36* MP0002398_abnormal_bone_marrow1.66564565
37MP0004381_abnormal_hair_follicle1.66113520
38MP0005025_abnormal_response_to1.65398506
39MP0000604_amyloidosis1.58912237
40MP0005310_abnormal_salivary_gland1.58254943
41MP0005058_abnormal_lysosome_morphology1.57846646
42MP0004270_analgesia1.56817946
43MP0006082_CNS_inflammation1.55804250
44MP0003880_abnormal_central_pattern1.55401689
45MP0005451_abnormal_body_composition1.53231310
46* MP0000716_abnormal_immune_system1.51809331
47MP0003763_abnormal_thymus_physiology1.50905211
48MP0008260_abnormal_autophagy1.50408543
49MP0002148_abnormal_hypersensitivity_rea1.48674522
50MP0001501_abnormal_sleep_pattern1.48594404
51MP0008877_abnormal_DNA_methylation1.47613939
52MP0009785_altered_susceptibility_to1.46513861
53MP0005075_abnormal_melanosome_morpholog1.44534243
54MP0003191_abnormal_cellular_cholesterol1.43440542
55MP0002132_abnormal_respiratory_system1.43300768
56MP0002006_tumorigenesis1.42810192
57MP0003787_abnormal_imprinting1.40239089
58MP0000015_abnormal_ear_pigmentation1.39870194
59MP0003221_abnormal_cardiomyocyte_apopto1.38003335
60MP0009333_abnormal_splenocyte_physiolog1.36729317
61MP0002572_abnormal_emotion/affect_behav1.33403601
62MP0009046_muscle_twitch1.32537754
63MP0003866_abnormal_defecation1.29215404
64MP0004947_skin_inflammation1.29051122
65MP0002332_abnormal_exercise_endurance1.28302497
66MP0001873_stomach_inflammation1.28013110
67MP0009780_abnormal_chondrocyte_physiolo1.25138202
68MP0000465_gastrointestinal_hemorrhage1.24446533
69MP0000689_abnormal_spleen_morphology1.23211720
70MP0001845_abnormal_inflammatory_respons1.22621138
71MP0005166_decreased_susceptibility_to1.22336448
72MP0001968_abnormal_touch/_nociception1.21955934
73MP0004484_altered_response_of1.21536017
74MP0010155_abnormal_intestine_physiology1.21207863
75MP0005167_abnormal_blood-brain_barrier1.20751547
76MP0008569_lethality_at_weaning1.19905971
77MP0008874_decreased_physiological_sensi1.19738631
78MP0002722_abnormal_immune_system1.16933452
79MP0003633_abnormal_nervous_system1.16595885
80MP0010234_abnormal_vibrissa_follicle1.16345725
81* MP0002429_abnormal_blood_cell1.15406131
82MP0002405_respiratory_system_inflammati1.14570838
83MP0003045_fibrosis1.14391342
84MP0002138_abnormal_hepatobiliary_system1.12937426
85MP0004811_abnormal_neuron_physiology1.12637871
86MP0005076_abnormal_cell_differentiation1.11272171
87MP0000703_abnormal_thymus_morphology1.11262780
88MP0003329_amyloid_beta_deposits1.07100606
89MP0004145_abnormal_muscle_electrophysio1.04891967
90MP0001851_eye_inflammation1.02668647
91MP0004036_abnormal_muscle_relaxation1.02226447
92MP0002735_abnormal_chemical_nociception1.01024833
93MP0004130_abnormal_muscle_cell1.00566051
94MP0004858_abnormal_nervous_system0.99412422
95MP0010307_abnormal_tumor_latency0.99346568
96MP0004808_abnormal_hematopoietic_stem0.98253991
97MP0002736_abnormal_nociception_after0.97908530
98MP0001853_heart_inflammation0.97229349
99MP0001533_abnormal_skeleton_physiology0.96843888
100MP0005386_behavior/neurological_phenoty0.94295043
101MP0004924_abnormal_behavior0.94295043
102MP0004883_abnormal_blood_vessel0.92874024
103MP0003879_abnormal_hair_cell0.92743903
104MP0002396_abnormal_hematopoietic_system0.91345423
105MP0002163_abnormal_gland_morphology0.91337639
106MP0005535_abnormal_body_temperature0.90362167
107MP0002127_abnormal_cardiovascular_syste0.89576493
108MP0009278_abnormal_bone_marrow0.88901966
109MP0008469_abnormal_protein_level0.88336788
110MP0003656_abnormal_erythrocyte_physiolo0.88319252
111MP0001970_abnormal_pain_threshold0.87836422
112MP0001486_abnormal_startle_reflex0.86234743
113MP0002693_abnormal_pancreas_physiology0.85426871
114MP0002733_abnormal_thermal_nociception0.84211991
115MP0002272_abnormal_nervous_system0.83497776
116MP0001545_abnormal_hematopoietic_system0.82449830
117MP0005397_hematopoietic_system_phenotyp0.82449830
118MP0005174_abnormal_tail_pigmentation0.82415056
119MP0001440_abnormal_grooming_behavior0.81584479
120MP0002928_abnormal_bile_duct0.79968132
121MP0002106_abnormal_muscle_physiology0.79898642
122MP0009764_decreased_sensitivity_to0.79671631
123MP0003690_abnormal_glial_cell0.78465384
124MP0002998_abnormal_bone_remodeling0.77166335
125MP0002067_abnormal_sensory_capabilities0.75457552
126MP0003631_nervous_system_phenotype0.74408775
127MP0000749_muscle_degeneration0.74319317
128MP0005266_abnormal_metabolism0.71018480
129MP0000858_altered_metastatic_potential0.70987068
130MP0001986_abnormal_taste_sensitivity0.70982697
131MP0000371_diluted_coat_color0.70844907
132MP0002277_abnormal_respiratory_mucosa0.67076416
133MP0009115_abnormal_fat_cell0.61517627
134MP0004084_abnormal_cardiac_muscle0.60650961
135MP0004087_abnormal_muscle_fiber0.60524037
136MP0003091_abnormal_cell_migration0.58071051
137MP0002971_abnormal_brown_adipose0.55563258

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)3.76519071
2Recurrent bacterial skin infections (HP:0005406)3.63074666
3Eczematoid dermatitis (HP:0000976)3.57087926
4Focal motor seizures (HP:0011153)3.40086058
5Spontaneous hematomas (HP:0007420)3.33961786
6Papilledema (HP:0001085)3.28611256
7Hypochromic microcytic anemia (HP:0004840)3.27879314
8Visual hallucinations (HP:0002367)3.27543748
9Recurrent fungal infections (HP:0002841)3.13738291
10Colitis (HP:0002583)3.11354776
11Recurrent viral infections (HP:0004429)3.08366427
12Encephalitis (HP:0002383)3.02729183
13Lymphopenia (HP:0001888)2.85238865
14Recurrent gram-negative bacterial infections (HP:0005420)2.84511431
15Focal seizures (HP:0007359)2.83371490
16Difficulty running (HP:0009046)2.78577035
17Mediastinal lymphadenopathy (HP:0100721)2.75646941
18Muscle fiber inclusion bodies (HP:0100299)2.72644002
19Gastrointestinal stroma tumor (HP:0100723)2.72547287
20Inflammation of the large intestine (HP:0002037)2.71403070
21Osteomyelitis (HP:0002754)2.69528340
22Abnormal delayed hypersensitivity skin test (HP:0002963)2.67670979
23Myokymia (HP:0002411)2.65898033
24Keratoconjunctivitis sicca (HP:0001097)2.64652868
25Nemaline bodies (HP:0003798)2.62039272
26Gastrointestinal inflammation (HP:0004386)2.62022143
27Increased cerebral lipofuscin (HP:0011813)2.60039636
28Verrucae (HP:0200043)2.59696776
29Papilloma (HP:0012740)2.59696776
30Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.57598419
31Elevated erythrocyte sedimentation rate (HP:0003565)2.55062059
32Cellulitis (HP:0100658)2.54945330
33Chronic otitis media (HP:0000389)2.54478353
34Exercise-induced myalgia (HP:0003738)2.54201492
35Abnormality of cells of the lymphoid lineage (HP:0012140)2.54082281
36Leukocytosis (HP:0001974)2.53071253
37Myositis (HP:0100614)2.52552536
38Recurrent skin infections (HP:0001581)2.50344680
39Calf muscle hypertrophy (HP:0008981)2.49836329
40Muscle hypertrophy of the lower extremities (HP:0008968)2.48494514
41Chronic mucocutaneous candidiasis (HP:0002728)2.46438109
42Recurrent cutaneous fungal infections (HP:0011370)2.46438109
43Microcytic anemia (HP:0001935)2.45448739
44Absence seizures (HP:0002121)2.44768627
45Atonic seizures (HP:0010819)2.44224841
46Prolonged bleeding time (HP:0003010)2.42360756
47Testicular neoplasm (HP:0010788)2.42276349
48Agammaglobulinemia (HP:0004432)2.39543155
49Keratoconjunctivitis (HP:0001096)2.38730104
50Urinary bladder sphincter dysfunction (HP:0002839)2.37520381
51Hypochromic anemia (HP:0001931)2.34419068
52Hematochezia (HP:0002573)2.32904460
53Frequent falls (HP:0002359)2.32752982
54Slow saccadic eye movements (HP:0000514)2.31654422
55T lymphocytopenia (HP:0005403)2.31038865
56Dysmetric saccades (HP:0000641)2.30581830
57Resting tremor (HP:0002322)2.30572259
58Acute hepatic failure (HP:0006554)2.30450740
59Meningitis (HP:0001287)2.29707021
60Retrobulbar optic neuritis (HP:0100654)2.28820764
61Optic neuritis (HP:0100653)2.28820764
62Abnormality of the fingertips (HP:0001211)2.26589709
63Abnormality of T cell number (HP:0011839)2.26487232
64Macroorchidism (HP:0000053)2.26200364
65Inappropriate behavior (HP:0000719)2.25725147
66EMG: myopathic abnormalities (HP:0003458)2.25429078
67Hemoptysis (HP:0002105)2.24633061
68Abnormality of the peritoneum (HP:0002585)2.24373566
69Mutism (HP:0002300)2.23931469
70Vasculitis (HP:0002633)2.23276741
71Stomatitis (HP:0010280)2.20875380
72Systemic lupus erythematosus (HP:0002725)2.20461943
73Postural instability (HP:0002172)2.19876842
74Arterial thrombosis (HP:0004420)2.19647365
75Chest pain (HP:0100749)2.18421007
76Pulmonary embolism (HP:0002204)2.18150383
77Hypoplasia of the thymus (HP:0000778)2.17908544
78Febrile seizures (HP:0002373)2.16121713
79Progressive inability to walk (HP:0002505)2.15843817
80Truncal ataxia (HP:0002078)2.15711800
81Abnormal social behavior (HP:0012433)2.15510576
82Impaired social interactions (HP:0000735)2.15510576
83Urticaria (HP:0001025)2.15246414
84Sepsis (HP:0100806)2.14361741
85Orchitis (HP:0100796)2.13513160
86Gingival bleeding (HP:0000225)2.12721932
87Impaired vibration sensation in the lower limbs (HP:0002166)2.12675486
88Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.12311925
89Urinary urgency (HP:0000012)2.12274863
90Thyroiditis (HP:0100646)2.12086365
91Depression (HP:0000716)2.11431555
92Supranuclear gaze palsy (HP:0000605)2.11050134
93Chronic obstructive pulmonary disease (HP:0006510)2.10789386
94Obstructive lung disease (HP:0006536)2.10789386
95Recurrent sinusitis (HP:0011108)2.09871788
96Dialeptic seizures (HP:0011146)2.09659379
97Poor eye contact (HP:0000817)2.09590085
98Gingivitis (HP:0000230)2.09352977
99Recurrent bronchitis (HP:0002837)2.08560516
100IgG deficiency (HP:0004315)2.06793766
101Impaired smooth pursuit (HP:0007772)2.06729596
102Panhypogammaglobulinemia (HP:0003139)2.06296244
103Autoimmune thrombocytopenia (HP:0001973)2.06106625
104Global brain atrophy (HP:0002283)2.04543794
105Disinhibition (HP:0000734)2.04291034
106Recurrent pneumonia (HP:0006532)2.03568305
107Subaortic stenosis (HP:0001682)2.03055016
108Abnormality of the left ventricular outflow tract (HP:0011103)2.03055016
109Pulmonary infiltrates (HP:0002113)2.02602546
110Increased neuronal autofluorescent lipopigment (HP:0002074)2.02548245
111Abnormality of binocular vision (HP:0011514)2.02266339
112Diplopia (HP:0000651)2.02266339
113Centrally nucleated skeletal muscle fibers (HP:0003687)2.02040744
114Periodontitis (HP:0000704)2.01251278
115Epistaxis (HP:0000421)2.00874005
116Viral hepatitis (HP:0006562)1.99576808
117Generalized tonic-clonic seizures (HP:0002069)1.99286368
118Neuronal loss in central nervous system (HP:0002529)1.98151458
119Abnormality of liposaccharide metabolism (HP:0010968)1.97208124
120Abnormality of glycosphingolipid metabolism (HP:0004343)1.97208124
121Abnormality of glycolipid metabolism (HP:0010969)1.97208124
122Dysostosis multiplex (HP:0000943)1.95874333
123Hemiplegia (HP:0002301)1.95732463
124IgM deficiency (HP:0002850)1.94307784
125Muscle fiber splitting (HP:0003555)1.94276909
126Pustule (HP:0200039)1.93624266
127Increased IgE level (HP:0003212)1.92426631
128Granulocytopenia (HP:0001913)1.92276180
129Hyporeflexia of lower limbs (HP:0002600)1.91454451
130Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.89910787
131Degeneration of the lateral corticospinal tracts (HP:0002314)1.89910787
132Autoimmune hemolytic anemia (HP:0001890)1.89693491
133Eosinophilia (HP:0001880)1.89277453
134Abnormality of macrophages (HP:0004311)1.88852972
135Chronic diarrhea (HP:0002028)1.88140613
136Abnormality of T cell physiology (HP:0011840)1.87847537
137Fatigue (HP:0012378)1.87680223
138Abnormality of the periventricular white matter (HP:0002518)1.87225563
139Abnormality of eosinophils (HP:0001879)1.86954132
140Gonadal dysgenesis (HP:0000133)1.86880577
141Abnormality of T cells (HP:0002843)1.85530032
142Deep palmar crease (HP:0006191)1.84357336
143Epileptic encephalopathy (HP:0200134)1.82841250
144Hyperacusis (HP:0010780)1.82541487
145Gastrointestinal infarctions (HP:0005244)1.81242472
146Nasal polyposis (HP:0100582)1.80578985
147Apathy (HP:0000741)1.79604680
148Pointed chin (HP:0000307)1.79490180
149Stereotypic behavior (HP:0000733)1.79433441
150Striae distensae (HP:0001065)1.76984409

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK44.03098670
2MAP3K133.19873921
3MAP3K93.16865658
4MAP4K12.69389741
5OBSCN2.65220604
6EPHA42.47247003
7PRPF4B2.35053701
8SIK22.34181168
9TYK22.11443423
10CDK192.11404113
11DAPK22.03909770
12FES2.03097751
13GRK61.97875747
14KSR21.92642391
15NTRK31.88990204
16JAK11.88544285
17PKN21.75056398
18MAP3K101.71709184
19MAP3K41.71478615
20TEC1.63057158
21CAMKK11.62752041
22TRIB31.57768534
23MAP3K141.50339405
24SYK1.49827568
25JAK31.44798400
26TAOK31.42730660
27NLK1.42047545
28CAMK1G1.38989721
29TBK11.33346952
30HCK1.32510499
31TAOK11.30120555
32IKBKE1.27877038
33TXK1.27709488
34RIPK11.23403834
35SCYL21.23280147
36MAP2K41.22314177
37TGFBR21.20650730
38JAK21.16762128
39SGK31.16705674
40BLK1.16414319
41DAPK11.14858294
42PRKCH1.13462119
43PDK11.11759473
44ZAP701.10623834
45CSF1R1.10525108
46FGFR31.09934239
47RET1.08952807
48ITK1.06605169
49PIM11.06105601
50MAP3K71.05549049
51EEF2K1.03716100
52ALK1.03676712
53MARK11.00835792
54IRAK40.99361134
55KSR10.97916545
56STK110.97754114
57MARK20.96359033
58PIK3CG0.95425472
59CDK40.94931251
60MINK10.94910795
61YES10.94056014
62SGK2230.91321279
63SGK4940.91321279
64CSK0.91190802
65CDK50.89930597
66NTRK20.89366245
67TRPM70.89106515
68RAF10.87908844
69KIT0.86308151
70CAMKK20.85531331
71PTK60.84358519
72PRKD30.81206575
73IRAK20.80379818
74MAP3K20.79733583
75LCK0.79008131
76MAP2K70.78503125
77PAK60.78339721
78MAPK70.78156254
79SGK20.77914704
80PDPK10.77830742
81CAMK1D0.77407866
82SGK10.76297295
83EPHB10.74998302
84IRAK10.73778155
85TNK20.73622677
86BTK0.73417244
87PRKCQ0.72588895
88FGFR40.70493545
89DMPK0.69760639
90MAPK110.69069051
91MAPK120.68361208
92IKBKB0.67900387
93ACVR1B0.67769112
94MAP3K10.67735040
95BMPR20.67248012
96WNK10.66997815
97FGR0.65225731
98PINK10.64557766
99NTRK10.62854380
100MAP3K110.62526115
101DYRK1B0.62067077
102HIPK20.61186751
103ERN10.60363598
104CDK60.59981312
105TTN0.59164432
106STK100.58416662
107FYN0.58242400
108FGFR20.57691889
109CDK120.57624310
110MAP3K30.55873219
111MAP3K120.54653582
112PASK0.54378436
113LYN0.53908542
114MAP2K60.52703318
115DYRK1A0.52276160
116ARAF0.52051201
117MARK30.50893434
118MAP2K30.50704570
119BRD40.50223392
120TYRO30.47005224
121CLK10.45365926
122EGFR0.44827479
123CHUK0.43552627
124STK40.43176231
125RPS6KC10.41465560
126RPS6KL10.41465560
127MAP3K60.41267839
128PRKAA20.40548128
129NUAK10.40435393
130CAMK40.40420069
131MAPK40.40279827
132GRK50.37053893
133RPS6KA20.36163875
134STK240.35913343
135LRRK20.35545779
136FRK0.34543156
137MAP3K50.33988556

Predicted pathways (KEGG)

RankGene SetZ-score
1Graft-versus-host disease_Homo sapiens_hsa053322.43592362
2Autoimmune thyroid disease_Homo sapiens_hsa053202.37025873
3B cell receptor signaling pathway_Homo sapiens_hsa046622.11764698
4Osteoclast differentiation_Homo sapiens_hsa043801.88627511
5Long-term potentiation_Homo sapiens_hsa047201.83371383
6Olfactory transduction_Homo sapiens_hsa047401.81084608
7Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.78643485
8Asthma_Homo sapiens_hsa053101.68753234
9Viral myocarditis_Homo sapiens_hsa054161.66124347
10Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.62517923
11Type II diabetes mellitus_Homo sapiens_hsa049301.61741226
12Leishmaniasis_Homo sapiens_hsa051401.59372760
13Morphine addiction_Homo sapiens_hsa050321.58977921
14Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.57264687
15T cell receptor signaling pathway_Homo sapiens_hsa046601.53204412
16Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.48013172
17Chemokine signaling pathway_Homo sapiens_hsa040621.44874316
18Circadian entrainment_Homo sapiens_hsa047131.40978244
19Primary immunodeficiency_Homo sapiens_hsa053401.39597905
20Aldosterone synthesis and secretion_Homo sapiens_hsa049251.37238471
21Phosphatidylinositol signaling system_Homo sapiens_hsa040701.36000490
22Renin secretion_Homo sapiens_hsa049241.34413975
23Synaptic vesicle cycle_Homo sapiens_hsa047211.32616844
24Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.30622576
25Nicotine addiction_Homo sapiens_hsa050331.30505256
26Salivary secretion_Homo sapiens_hsa049701.30036531
27Cholinergic synapse_Homo sapiens_hsa047251.27613555
28Amphetamine addiction_Homo sapiens_hsa050311.27553054
29Neurotrophin signaling pathway_Homo sapiens_hsa047221.26944013
30Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.26092761
31Toll-like receptor signaling pathway_Homo sapiens_hsa046201.25764792
32Dopaminergic synapse_Homo sapiens_hsa047281.25397975
33Glutamatergic synapse_Homo sapiens_hsa047241.24881349
34Oxytocin signaling pathway_Homo sapiens_hsa049211.24725001
35Herpes simplex infection_Homo sapiens_hsa051681.24337982
36GABAergic synapse_Homo sapiens_hsa047271.22709287
37Tuberculosis_Homo sapiens_hsa051521.21540845
38Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.18277286
39Glioma_Homo sapiens_hsa052141.17702115
40Non-small cell lung cancer_Homo sapiens_hsa052231.17606967
41Staphylococcus aureus infection_Homo sapiens_hsa051501.17489638
42Carbohydrate digestion and absorption_Homo sapiens_hsa049731.15238644
43Gastric acid secretion_Homo sapiens_hsa049711.13122367
44GnRH signaling pathway_Homo sapiens_hsa049121.12756238
45VEGF signaling pathway_Homo sapiens_hsa043701.08519859
46NF-kappa B signaling pathway_Homo sapiens_hsa040641.07647911
47Chronic myeloid leukemia_Homo sapiens_hsa052201.05515298
48Intestinal immune network for IgA production_Homo sapiens_hsa046721.05367516
49Dorso-ventral axis formation_Homo sapiens_hsa043201.05215095
50Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.02901941
51Insulin secretion_Homo sapiens_hsa049111.02677379
52Estrogen signaling pathway_Homo sapiens_hsa049151.02133395
53Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.01718151
54Malaria_Homo sapiens_hsa051441.01628517
55Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.99439237
56Toxoplasmosis_Homo sapiens_hsa051450.99089215
57NOD-like receptor signaling pathway_Homo sapiens_hsa046210.99041907
58mTOR signaling pathway_Homo sapiens_hsa041500.98949930
59Leukocyte transendothelial migration_Homo sapiens_hsa046700.98263845
60Measles_Homo sapiens_hsa051620.97875991
61Prolactin signaling pathway_Homo sapiens_hsa049170.97850929
62Platelet activation_Homo sapiens_hsa046110.96753202
63Cocaine addiction_Homo sapiens_hsa050300.96555588
64TNF signaling pathway_Homo sapiens_hsa046680.95958010
65Pancreatic cancer_Homo sapiens_hsa052120.95569305
66Long-term depression_Homo sapiens_hsa047300.94170707
67Type I diabetes mellitus_Homo sapiens_hsa049400.91436927
68Calcium signaling pathway_Homo sapiens_hsa040200.89294031
69Pertussis_Homo sapiens_hsa051330.88272876
70Acute myeloid leukemia_Homo sapiens_hsa052210.87488469
71Influenza A_Homo sapiens_hsa051640.87345403
72cGMP-PKG signaling pathway_Homo sapiens_hsa040220.83476630
73MAPK signaling pathway_Homo sapiens_hsa040100.83074226
74Phospholipase D signaling pathway_Homo sapiens_hsa040720.82897257
75cAMP signaling pathway_Homo sapiens_hsa040240.82760178
76Insulin resistance_Homo sapiens_hsa049310.82218468
77Hepatitis C_Homo sapiens_hsa051600.81894235
78Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.79903872
79RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.79767857
80ErbB signaling pathway_Homo sapiens_hsa040120.79030435
81Hepatitis B_Homo sapiens_hsa051610.77814237
82Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.76820228
83Regulation of autophagy_Homo sapiens_hsa041400.74786264
84Inositol phosphate metabolism_Homo sapiens_hsa005620.74764691
85Antigen processing and presentation_Homo sapiens_hsa046120.73776284
86Adipocytokine signaling pathway_Homo sapiens_hsa049200.72643950
87Choline metabolism in cancer_Homo sapiens_hsa052310.71711247
88Legionellosis_Homo sapiens_hsa051340.71629719
89Salmonella infection_Homo sapiens_hsa051320.71006146
90Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.70752339
91Insulin signaling pathway_Homo sapiens_hsa049100.70314061
92Sphingolipid signaling pathway_Homo sapiens_hsa040710.69490453
93Colorectal cancer_Homo sapiens_hsa052100.69164411
94Nitrogen metabolism_Homo sapiens_hsa009100.68749738
95AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.67271719
96Gap junction_Homo sapiens_hsa045400.66853681
97Jak-STAT signaling pathway_Homo sapiens_hsa046300.66598773
98Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.66106478
99Longevity regulating pathway - mammal_Homo sapiens_hsa042110.64915891
100Shigellosis_Homo sapiens_hsa051310.64717568
101Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.64711000
102HTLV-I infection_Homo sapiens_hsa051660.64580637
103FoxO signaling pathway_Homo sapiens_hsa040680.64576195
104Phagosome_Homo sapiens_hsa041450.64525972
105Endocytosis_Homo sapiens_hsa041440.64308456
106Thyroid hormone signaling pathway_Homo sapiens_hsa049190.63913406
107Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.63525096
108Renal cell carcinoma_Homo sapiens_hsa052110.63204313
109Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.62791637
110African trypanosomiasis_Homo sapiens_hsa051430.62287062
111Serotonergic synapse_Homo sapiens_hsa047260.62215423
112Apoptosis_Homo sapiens_hsa042100.62095696
113Endometrial cancer_Homo sapiens_hsa052130.61971144
114Hematopoietic cell lineage_Homo sapiens_hsa046400.61739754
115Allograft rejection_Homo sapiens_hsa053300.60993131
116Rheumatoid arthritis_Homo sapiens_hsa053230.60971394
117Epstein-Barr virus infection_Homo sapiens_hsa051690.58564584
118Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.54065193
119Viral carcinogenesis_Homo sapiens_hsa052030.53089950
120Transcriptional misregulation in cancer_Homo sapiens_hsa052020.52478884
121Prostate cancer_Homo sapiens_hsa052150.51720059
122Vascular smooth muscle contraction_Homo sapiens_hsa042700.49413903
123Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.48344188
124HIF-1 signaling pathway_Homo sapiens_hsa040660.44687370
125Systemic lupus erythematosus_Homo sapiens_hsa053220.44061784
126Glucagon signaling pathway_Homo sapiens_hsa049220.40401898

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