PLCXD2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.12873119
2L-phenylalanine catabolic process (GO:0006559)5.12873119
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.77214378
4L-phenylalanine metabolic process (GO:0006558)4.77214378
5glutamate secretion (GO:0014047)4.58571390
6aromatic amino acid family catabolic process (GO:0009074)4.45390154
7gamma-aminobutyric acid transport (GO:0015812)4.14589593
8bile acid biosynthetic process (GO:0006699)4.07312455
9protein K11-linked deubiquitination (GO:0035871)4.04134312
10synaptic vesicle exocytosis (GO:0016079)4.00572812
11regulation of short-term neuronal synaptic plasticity (GO:0048172)4.00454352
12kynurenine metabolic process (GO:0070189)3.94318325
13indole-containing compound catabolic process (GO:0042436)3.89587476
14indolalkylamine catabolic process (GO:0046218)3.89587476
15tryptophan catabolic process (GO:0006569)3.89587476
16triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.88143201
17vocalization behavior (GO:0071625)3.77869836
18neurotransmitter secretion (GO:0007269)3.77495922
19glutamate metabolic process (GO:0006536)3.74937035
20ionotropic glutamate receptor signaling pathway (GO:0035235)3.74498914
21urea metabolic process (GO:0019627)3.72688500
22urea cycle (GO:0000050)3.72688500
23positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.68846925
24negative regulation of fibrinolysis (GO:0051918)3.68745573
25righting reflex (GO:0060013)3.67876789
26dicarboxylic acid biosynthetic process (GO:0043650)3.66145639
27regulation of fibrinolysis (GO:0051917)3.64528463
28alpha-linolenic acid metabolic process (GO:0036109)3.64079912
29regulation of protein activation cascade (GO:2000257)3.63321662
30cellular ketone body metabolic process (GO:0046950)3.63063858
31tryptophan metabolic process (GO:0006568)3.61300595
32regulation of synaptic vesicle exocytosis (GO:2000300)3.60539380
33complement activation, alternative pathway (GO:0006957)3.60463500
34neuron cell-cell adhesion (GO:0007158)3.60337876
35high-density lipoprotein particle remodeling (GO:0034375)3.58280633
36negative regulation of cytosolic calcium ion concentration (GO:0051481)3.56202843
37positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.55619631
38synaptic vesicle maturation (GO:0016188)3.55003411
39startle response (GO:0001964)3.51306288
40pyrimidine nucleobase catabolic process (GO:0006208)3.49078610
41phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.48832478
42central nervous system projection neuron axonogenesis (GO:0021952)3.47771893
43regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.47478910
44coenzyme catabolic process (GO:0009109)3.47374100
45dopamine biosynthetic process (GO:0042416)3.45497705
46tyrosine metabolic process (GO:0006570)3.43600885
47bile acid metabolic process (GO:0008206)3.40892408
48glyoxylate metabolic process (GO:0046487)3.38931198
49nitrogen cycle metabolic process (GO:0071941)3.37251128
50regulation of complement activation (GO:0030449)3.36350181
51synaptic vesicle docking involved in exocytosis (GO:0016081)3.36088768
52membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.34879269
53protein carboxylation (GO:0018214)3.34136417
54peptidyl-glutamic acid carboxylation (GO:0017187)3.34136417
55locomotory exploration behavior (GO:0035641)3.34070726
56dendritic spine morphogenesis (GO:0060997)3.33122803
57neurotransmitter-gated ion channel clustering (GO:0072578)3.32476338
58regulation of ARF protein signal transduction (GO:0032012)3.32142254
59protein localization to synapse (GO:0035418)3.27873803
60aromatic amino acid family metabolic process (GO:0009072)3.26013002
61establishment of nucleus localization (GO:0040023)3.25151627
62neuronal action potential propagation (GO:0019227)3.23959674
63central nervous system neuron axonogenesis (GO:0021955)3.23526299
64cysteine metabolic process (GO:0006534)3.23237295
65glutamate receptor signaling pathway (GO:0007215)3.20819675
66regulation of glutamate receptor signaling pathway (GO:1900449)3.16105725
67presynaptic membrane organization (GO:0097090)3.15798862
68regulation of Rac protein signal transduction (GO:0035020)3.15411348
69regulation of synaptic vesicle transport (GO:1902803)3.15224838
70nucleobase catabolic process (GO:0046113)3.12741058
71ketone body metabolic process (GO:1902224)3.12726872
72establishment of protein localization to Golgi (GO:0072600)3.10458398
73auditory behavior (GO:0031223)3.10375391
74reverse cholesterol transport (GO:0043691)3.10043189
75triglyceride homeostasis (GO:0070328)3.09313834
76acylglycerol homeostasis (GO:0055090)3.09313834
77negative regulation of neurotransmitter secretion (GO:0046929)3.09202264
78axonal fasciculation (GO:0007413)3.08130301
79regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.07619277
80bile acid and bile salt transport (GO:0015721)3.04053806
81sulfur amino acid catabolic process (GO:0000098)3.02750914
82plasma lipoprotein particle remodeling (GO:0034369)3.01520445
83protein-lipid complex remodeling (GO:0034368)3.01520445
84macromolecular complex remodeling (GO:0034367)3.01520445
85alpha-amino acid catabolic process (GO:1901606)3.01080530
86negative regulation of neurotransmitter transport (GO:0051589)3.01022397
87neurotransmitter transport (GO:0006836)3.00462903
88regulation of cholesterol homeostasis (GO:2000188)2.99535775
89indolalkylamine metabolic process (GO:0006586)2.98134719
90alkaloid metabolic process (GO:0009820)2.95399151
91regulation of neurotransmitter levels (GO:0001505)2.94689866
92synaptic transmission, glutamatergic (GO:0035249)2.94483345
93behavioral response to cocaine (GO:0048148)2.93116360
94serine family amino acid catabolic process (GO:0009071)2.92914484
95histone H3-K4 trimethylation (GO:0080182)2.90875377
96lysine catabolic process (GO:0006554)2.90860289
97lysine metabolic process (GO:0006553)2.90860289
98insulin secretion (GO:0030073)2.90578788
99dicarboxylic acid catabolic process (GO:0043649)2.89777492
100protein targeting to Golgi (GO:0000042)2.86828677
101regulation of cholesterol esterification (GO:0010872)2.86583864
102neuron recognition (GO:0008038)2.85782003
103negative regulation of cAMP-mediated signaling (GO:0043951)2.85488303
104phospholipid efflux (GO:0033700)2.82637381
105cellular modified amino acid catabolic process (GO:0042219)2.80535724
106neural tube formation (GO:0001841)2.80376681
107cholesterol efflux (GO:0033344)2.80332069
108fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.80234895
109negative regulation of sterol transport (GO:0032372)2.79704992
110negative regulation of cholesterol transport (GO:0032375)2.79704992
111negative regulation of protein activation cascade (GO:2000258)2.78515577
112cellular amino acid catabolic process (GO:0009063)2.78123568
113cell differentiation in hindbrain (GO:0021533)2.78120933
114regulation of triglyceride catabolic process (GO:0010896)2.77967669
115cerebellar granule cell differentiation (GO:0021707)2.77333534
116detection of calcium ion (GO:0005513)2.76224834
117homocysteine metabolic process (GO:0050667)2.75245476
118atrial cardiac muscle cell action potential (GO:0086014)2.74670254
119ethanol oxidation (GO:0006069)2.74384047
120cytoplasmic mRNA processing body assembly (GO:0033962)2.73609780
121serotonin metabolic process (GO:0042428)2.73527214
122layer formation in cerebral cortex (GO:0021819)2.73036818
123cytolysis (GO:0019835)2.72622534
124postsynaptic membrane organization (GO:0001941)2.71048179
125cellular response to ethanol (GO:0071361)2.69687655
126membrane depolarization during action potential (GO:0086010)2.68984324
127presynaptic membrane assembly (GO:0097105)2.68332445
128activated T cell proliferation (GO:0050798)2.67312584
129drug catabolic process (GO:0042737)2.66803125
130benzene-containing compound metabolic process (GO:0042537)2.66713974
131exploration behavior (GO:0035640)2.65760096
132cerebellar Purkinje cell differentiation (GO:0021702)2.65012748
133nerve growth factor signaling pathway (GO:0038180)2.63826162
134regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.63740436
135endocrine pancreas development (GO:0031018)2.63640012
136neuron-neuron synaptic transmission (GO:0007270)2.62952468
137regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.62661762
138regulation of long-term neuronal synaptic plasticity (GO:0048169)2.62515212
139prepulse inhibition (GO:0060134)2.61773777
140catecholamine transport (GO:0051937)2.61043029
141retrograde transport, vesicle recycling within Golgi (GO:0000301)2.60767390
142regulation of postsynaptic membrane potential (GO:0060078)2.60516820
143regulation of bile acid biosynthetic process (GO:0070857)2.59796099
144regulation of neuronal synaptic plasticity (GO:0048168)2.59343214
145indole-containing compound metabolic process (GO:0042430)2.58534082
146mechanosensory behavior (GO:0007638)2.57216412
147negative regulation of dendrite development (GO:2000171)2.56584928
148gamma-aminobutyric acid signaling pathway (GO:0007214)2.56134792
149protein K48-linked deubiquitination (GO:0071108)2.56121194
150long-term synaptic potentiation (GO:0060291)2.55658745
151inositol phosphate catabolic process (GO:0071545)2.55279961
152phospholipid translocation (GO:0045332)2.54834583
153lipid translocation (GO:0034204)2.54834583
154cellular response to interleukin-15 (GO:0071350)2.53722596
155regulation of neurotransmitter secretion (GO:0046928)2.51658078
156macroautophagy (GO:0016236)2.50640070
157dendrite morphogenesis (GO:0048813)2.50255650
158positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.49432424
159regulation of respiratory gaseous exchange (GO:0043576)2.48961488
160regulation of glucokinase activity (GO:0033131)2.48861485
161regulation of hexokinase activity (GO:1903299)2.48861485
162peptidyl-threonine dephosphorylation (GO:0035970)2.48413626
163primary amino compound metabolic process (GO:1901160)2.47334530
164regulation of excitatory postsynaptic membrane potential (GO:0060079)2.46490662
165early endosome to late endosome transport (GO:0045022)2.46102673
166reflex (GO:0060004)2.45350394
167negative regulation of dendrite morphogenesis (GO:0050774)2.42920465
168chemosensory behavior (GO:0007635)2.42396876
169positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.40234425
170regulation of neurotransmitter transport (GO:0051588)2.40031501
171regulation of energy homeostasis (GO:2000505)2.38818693
172positive regulation of neurotransmitter transport (GO:0051590)2.38642343
173regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.38157809
174positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.38157809
175neuron maturation (GO:0042551)2.37498927
176proline transport (GO:0015824)2.36252474

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.00549438
2* RXR_22158963_ChIP-Seq_LIVER_Mouse3.54095408
3EZH2_22144423_ChIP-Seq_EOC_Human3.50642407
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.31469740
5GBX2_23144817_ChIP-Seq_PC3_Human3.05656619
6LXR_22158963_ChIP-Seq_LIVER_Mouse2.88623163
7PPARA_22158963_ChIP-Seq_LIVER_Mouse2.79231806
8* FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.68494309
9FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.47641102
10CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.45988460
11EGR1_23403033_ChIP-Seq_LIVER_Mouse2.44898977
12TAF15_26573619_Chip-Seq_HEK293_Human2.42518635
13SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.39502547
14SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.31683658
15NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.25538798
16IGF1R_20145208_ChIP-Seq_DFB_Human2.17718779
17GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.15241639
18REST_21632747_ChIP-Seq_MESCs_Mouse2.14930174
19NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.11473650
20JARID2_20064375_ChIP-Seq_MESCs_Mouse2.03515588
21SALL1_21062744_ChIP-ChIP_HESCs_Human2.02873616
22SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.99306853
23FLI1_27457419_Chip-Seq_LIVER_Mouse1.93686896
24MTF2_20144788_ChIP-Seq_MESCs_Mouse1.92899652
25DROSHA_22980978_ChIP-Seq_HELA_Human1.90166872
26SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.87306413
27EZH2_18974828_ChIP-Seq_MESCs_Mouse1.85621109
28RNF2_18974828_ChIP-Seq_MESCs_Mouse1.85621109
29STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.84254856
30REST_18959480_ChIP-ChIP_MESCs_Mouse1.82506388
31SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.81718729
32ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.79498572
33JARID2_20075857_ChIP-Seq_MESCs_Mouse1.78082685
34SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.73468876
35CTBP2_25329375_ChIP-Seq_LNCAP_Human1.73276903
36AR_21572438_ChIP-Seq_LNCaP_Human1.69676305
37FUS_26573619_Chip-Seq_HEK293_Human1.68628044
38RARB_27405468_Chip-Seq_BRAIN_Mouse1.65501791
39MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.62845017
40SUZ12_27294783_Chip-Seq_ESCs_Mouse1.61296477
41EZH2_27294783_Chip-Seq_ESCs_Mouse1.58717787
42CTBP1_25329375_ChIP-Seq_LNCAP_Human1.57795690
43EED_16625203_ChIP-ChIP_MESCs_Mouse1.54803191
44MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.54705034
45PCGF2_27294783_Chip-Seq_ESCs_Mouse1.52770050
46EZH2_27304074_Chip-Seq_ESCs_Mouse1.52639818
47* SMAD4_21799915_ChIP-Seq_A2780_Human1.51416853
48TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.51006610
49NANOG_18555785_Chip-Seq_ESCs_Mouse1.49812374
50CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.49787728
51ER_23166858_ChIP-Seq_MCF-7_Human1.48376297
52RBPJ_22232070_ChIP-Seq_NCS_Mouse1.45277317
53SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.41584432
54PIAS1_25552417_ChIP-Seq_VCAP_Human1.39882345
55CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.38674012
56SUZ12_27294783_Chip-Seq_NPCs_Mouse1.36678707
57TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.36304792
58* CTNNB1_20460455_ChIP-Seq_HCT116_Human1.33667022
59ZFP57_27257070_Chip-Seq_ESCs_Mouse1.33365549
60RNF2_27304074_Chip-Seq_ESCs_Mouse1.32982869
61ERG_21242973_ChIP-ChIP_JURKAT_Human1.32288868
62PCGF2_27294783_Chip-Seq_NPCs_Mouse1.31423361
63NR3C1_23031785_ChIP-Seq_PC12_Mouse1.28788854
64* P300_19829295_ChIP-Seq_ESCs_Human1.28775482
65SOX2_21211035_ChIP-Seq_LN229_Gbm1.28000168
66TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.27998022
67POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.27998022
68* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.27904010
69EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.25643168
70P53_22387025_ChIP-Seq_ESCs_Mouse1.24559282
71ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.24385031
72CMYC_18555785_Chip-Seq_ESCs_Mouse1.23952402
73* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.22754963
74E2F1_18555785_Chip-Seq_ESCs_Mouse1.22348745
75BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.22295507
76PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.21126214
77CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.19715264
78AR_25329375_ChIP-Seq_VCAP_Human1.19519215
79EZH2_27294783_Chip-Seq_NPCs_Mouse1.19510813
80FLI1_21867929_ChIP-Seq_TH2_Mouse1.19140539
81BCAT_22108803_ChIP-Seq_LS180_Human1.18139763
82SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.17174625
83NFE2_27457419_Chip-Seq_LIVER_Mouse1.16939137
84* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.16652059
85HTT_18923047_ChIP-ChIP_STHdh_Human1.16628288
86IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.16625697
87CBP_20019798_ChIP-Seq_JUKART_Human1.16625697
88SUZ12_18555785_Chip-Seq_ESCs_Mouse1.14208782
89CBX2_27304074_Chip-Seq_ESCs_Mouse1.14102951
90STAT3_23295773_ChIP-Seq_U87_Human1.12690894
91RNF2_27304074_Chip-Seq_NSC_Mouse1.12076487
92BMI1_23680149_ChIP-Seq_NPCS_Mouse1.11840429
93EWS_26573619_Chip-Seq_HEK293_Human1.10463041
94POU3F2_20337985_ChIP-ChIP_501MEL_Human1.09949897
95SMAD_19615063_ChIP-ChIP_OVARY_Human1.09723255
96EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.09640526
97VDR_22108803_ChIP-Seq_LS180_Human1.08891904
98* FOXA2_19822575_ChIP-Seq_HepG2_Human1.08742261
99TCF4_18268006_ChIP-ChIP_LS174T_Human1.08515443
100BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.07896105
101SMAD3_21741376_ChIP-Seq_EPCs_Human1.07176830
102AR_19668381_ChIP-Seq_PC3_Human1.05825771
103TCF4_22108803_ChIP-Seq_LS180_Human1.05773834
104RUNX_20019798_ChIP-Seq_JUKART_Human1.04550505
105DNAJC2_21179169_ChIP-ChIP_NT2_Human1.04192459
106TOP2B_26459242_ChIP-Seq_MCF-7_Human1.03391042
107TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.02715188
108* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.02216462
109VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.01242540
110TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.01145426
111P300_18555785_Chip-Seq_ESCs_Mouse1.01057338
112OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.00649982
113TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.00570222
114NOTCH1_21737748_ChIP-Seq_TLL_Human0.99898026
115STAT3_18555785_Chip-Seq_ESCs_Mouse0.99576754
116FOXO3_23340844_ChIP-Seq_DLD1_Human0.99054667
117ARNT_22903824_ChIP-Seq_MCF-7_Human0.99011205
118TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98577360
119CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.98473306
120AHR_22903824_ChIP-Seq_MCF-7_Human0.95924333
121* TCF4_23295773_ChIP-Seq_U87_Human0.95244875
122IKZF1_21737484_ChIP-ChIP_HCT116_Human0.94844457
123PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.94052705
124CDX2_19796622_ChIP-Seq_MESCs_Mouse0.92828269
125TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.91929055
126UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.90734587
127THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.89714468
128SMAD4_21741376_ChIP-Seq_HESCs_Human0.89390963
129ZNF274_21170338_ChIP-Seq_K562_Hela0.88683502
130GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88568259
131NRF2_20460467_ChIP-Seq_MEFs_Mouse0.88370203
132NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.88370203
133KDM2B_26808549_Chip-Seq_REH_Human0.85357360
134RUNX2_22187159_ChIP-Seq_PCA_Human0.85292823
135RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.85028577
136TP53_18474530_ChIP-ChIP_U2OS_Human0.84058967
137TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.83244073
138NR3C1_21868756_ChIP-Seq_MCF10A_Human0.81291207
139MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.80554464
140ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.80239897
141SMAD4_21741376_ChIP-Seq_EPCs_Human0.79912267
142RING1B_27294783_Chip-Seq_ESCs_Mouse0.79451376
143TP53_16413492_ChIP-PET_HCT116_Human0.78634319
144* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.78323145
145PRDM14_20953172_ChIP-Seq_ESCs_Human0.76718670
146RXR_22108803_ChIP-Seq_LS180_Human0.75801168

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.05838278
2MP0005360_urolithiasis4.72240131
3MP0005085_abnormal_gallbladder_physiolo4.13843491
4MP0005365_abnormal_bile_salt4.02077184
5MP0004859_abnormal_synaptic_plasticity3.70375397
6MP0003880_abnormal_central_pattern3.66300090
7MP0003787_abnormal_imprinting3.49143754
8MP0000569_abnormal_digit_pigmentation3.45513565
9MP0008875_abnormal_xenobiotic_pharmacok3.32509394
10MP0003635_abnormal_synaptic_transmissio2.82484774
11MP0008057_abnormal_DNA_replication2.56320289
12MP0009046_muscle_twitch2.50975967
13MP0010329_abnormal_lipoprotein_level2.45029475
14MP0004270_analgesia2.43749750
15MP0003252_abnormal_bile_duct2.43263345
16MP0009745_abnormal_behavioral_response2.39753251
17MP0002064_seizures2.29483017
18MP0001968_abnormal_touch/_nociception2.22196446
19MP0005083_abnormal_biliary_tract2.21785646
20MP0002063_abnormal_learning/memory/cond2.15963765
21MP0003329_amyloid_beta_deposits2.09032267
22MP0008877_abnormal_DNA_methylation2.04565253
23MP0009780_abnormal_chondrocyte_physiolo1.95666587
24MP0002572_abnormal_emotion/affect_behav1.94511535
25MP0003195_calcinosis1.92835190
26MP0002163_abnormal_gland_morphology1.92223132
27MP0005423_abnormal_somatic_nervous1.92046023
28MP0003868_abnormal_feces_composition1.87199334
29MP0002734_abnormal_mechanical_nocicepti1.80116046
30MP0002272_abnormal_nervous_system1.77213835
31MP0001501_abnormal_sleep_pattern1.73650856
32MP0002928_abnormal_bile_duct1.70145027
33MP0002822_catalepsy1.69566528
34MP0001188_hyperpigmentation1.68862206
35MP0001666_abnormal_nutrient_absorption1.68156234
36MP0005379_endocrine/exocrine_gland_phen1.64930693
37MP0002735_abnormal_chemical_nociception1.64153022
38MP0001486_abnormal_startle_reflex1.62952179
39MP0002736_abnormal_nociception_after1.62257486
40MP0006276_abnormal_autonomic_nervous1.61925673
41MP0000427_abnormal_hair_cycle1.61778624
42MP0005332_abnormal_amino_acid1.60916609
43MP0005645_abnormal_hypothalamus_physiol1.59637187
44MP0002638_abnormal_pupillary_reflex1.58973250
45MP0000604_amyloidosis1.55316771
46MP0001440_abnormal_grooming_behavior1.54180350
47MP0002067_abnormal_sensory_capabilities1.50840998
48MP0005248_abnormal_Harderian_gland1.50489955
49MP0003890_abnormal_embryonic-extraembry1.49083626
50MP0002733_abnormal_thermal_nociception1.48878645
51MP0001944_abnormal_pancreas_morphology1.47747689
52MP0002909_abnormal_adrenal_gland1.47186768
53MP0003763_abnormal_thymus_physiology1.45661127
54MP0002118_abnormal_lipid_homeostasis1.44511180
55MP0005386_behavior/neurological_phenoty1.42941964
56MP0004924_abnormal_behavior1.42941964
57MP0003806_abnormal_nucleotide_metabolis1.41927535
58MP0010386_abnormal_urinary_bladder1.41918506
59MP0002693_abnormal_pancreas_physiology1.41167341
60MP0003122_maternal_imprinting1.39719558
61MP0003121_genomic_imprinting1.37815563
62MP0005535_abnormal_body_temperature1.32176843
63MP0003879_abnormal_hair_cell1.23713471
64MP0001970_abnormal_pain_threshold1.23338246
65MP0002557_abnormal_social/conspecific_i1.22111409
66MP0005551_abnormal_eye_electrophysiolog1.21888291
67MP0002009_preneoplasia1.20906761
68MP0004019_abnormal_vitamin_homeostasis1.19942425
69MP0008872_abnormal_physiological_respon1.19869064
70MP0001502_abnormal_circadian_rhythm1.19420472
71MP0009840_abnormal_foam_cell1.18182393
72MP0000609_abnormal_liver_physiology1.17137948
73MP0006072_abnormal_retinal_apoptosis1.16825363
74MP0003633_abnormal_nervous_system1.16607214
75MP0008569_lethality_at_weaning1.16237448
76MP0002876_abnormal_thyroid_physiology1.16174394
77MP0002837_dystrophic_cardiac_calcinosis1.14679480
78MP0005584_abnormal_enzyme/coenzyme_acti1.13007594
79MP0002184_abnormal_innervation1.12720181
80MP0010678_abnormal_skin_adnexa1.10815789
81MP0001984_abnormal_olfaction1.09304265
82MP0005646_abnormal_pituitary_gland1.08753657
83MP0002138_abnormal_hepatobiliary_system1.08394644
84MP0004811_abnormal_neuron_physiology1.01002797
85MP0008874_decreased_physiological_sensi1.00923168
86MP0003191_abnormal_cellular_cholesterol0.99059158
87MP0003045_fibrosis0.98157821
88MP0004142_abnormal_muscle_tone0.97764087
89MP0003631_nervous_system_phenotype0.97190325
90MP0010352_gastrointestinal_tract_polyps0.96865156
91MP0002066_abnormal_motor_capabilities/c0.96725748
92MP0001905_abnormal_dopamine_level0.96165465
93MP0000631_abnormal_neuroendocrine_gland0.95989342
94MP0000955_abnormal_spinal_cord0.94539266
95MP0005174_abnormal_tail_pigmentation0.91487460
96MP0010234_abnormal_vibrissa_follicle0.91207173
97MP0001764_abnormal_homeostasis0.89737647
98MP0002090_abnormal_vision0.89277105
99MP0000778_abnormal_nervous_system0.88055318
100MP0002229_neurodegeneration0.87981259
101MP0008961_abnormal_basal_metabolism0.86155365
102MP0002078_abnormal_glucose_homeostasis0.85936717
103MP0005253_abnormal_eye_physiology0.85849936
104MP0004858_abnormal_nervous_system0.84215409
105MP0003690_abnormal_glial_cell0.83486588
106MP0000639_abnormal_adrenal_gland0.83414896
107MP0000013_abnormal_adipose_tissue0.82662537
108MP0003011_delayed_dark_adaptation0.82048951
109MP0004130_abnormal_muscle_cell0.81599508
110MP0002277_abnormal_respiratory_mucosa0.81476706
111MP0002069_abnormal_eating/drinking_beha0.79496266
112MP0005319_abnormal_enzyme/_coenzyme0.78711799
113MP0002882_abnormal_neuron_morphology0.77559544
114MP0001765_abnormal_ion_homeostasis0.77417951
115MP0004885_abnormal_endolymph0.76923950
116MP0001919_abnormal_reproductive_system0.76431863
117MP0003632_abnormal_nervous_system0.74953867
118MP0005448_abnormal_energy_balance0.74454331
119MP0003283_abnormal_digestive_organ0.72119027
120MP0000015_abnormal_ear_pigmentation0.70256393
121MP0003300_gastrointestinal_ulcer0.70161303
122MP0005220_abnormal_exocrine_pancreas0.67773188
123MP0004043_abnormal_pH_regulation0.67688299
124MP0003866_abnormal_defecation0.67449633
125MP0002082_postnatal_lethality0.67096233
126MP0010770_preweaning_lethality0.67096233
127MP0005084_abnormal_gallbladder_morpholo0.65528067
128MP0001529_abnormal_vocalization0.62557127
129MP0001177_atelectasis0.60855198
130MP0006035_abnormal_mitochondrial_morpho0.59524542
131MP0003953_abnormal_hormone_level0.56143172
132MP0005187_abnormal_penis_morphology0.55936918
133MP0004742_abnormal_vestibular_system0.52390410
134MP0003638_abnormal_response/metabolism_0.52287408
135MP0002152_abnormal_brain_morphology0.51923634
136MP0005334_abnormal_fat_pad0.51072370
137MP0002254_reproductive_system_inflammat0.51061201

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)5.16803638
2Abnormality of aromatic amino acid family metabolism (HP:0004338)5.12996395
3Intrahepatic cholestasis (HP:0001406)4.87324626
4Focal motor seizures (HP:0011153)4.83232936
5Prolonged partial thromboplastin time (HP:0003645)4.53077162
6Hypobetalipoproteinemia (HP:0003563)4.20906167
7Hyperventilation (HP:0002883)4.20458108
8Xanthomatosis (HP:0000991)4.11499969
9Abnormality of monocarboxylic acid metabolism (HP:0010996)4.06830789
10Complement deficiency (HP:0004431)4.00158122
11Hyperlipoproteinemia (HP:0010980)3.81378632
12Focal seizures (HP:0007359)3.63016364
13Visual hallucinations (HP:0002367)3.60003107
14Epileptic encephalopathy (HP:0200134)3.54160240
15Atonic seizures (HP:0010819)3.39709070
16Myokymia (HP:0002411)3.31145034
17Epidermoid cyst (HP:0200040)3.30302173
18Status epilepticus (HP:0002133)3.28516211
19Abnormality of the common coagulation pathway (HP:0010990)3.19567597
20Ketosis (HP:0001946)3.15238149
21Absence seizures (HP:0002121)3.06539932
22Progressive cerebellar ataxia (HP:0002073)3.01184730
23Conjugated hyperbilirubinemia (HP:0002908)2.99950086
24Hypolipoproteinemia (HP:0010981)2.96790481
25Hypothermia (HP:0002045)2.89793457
26Generalized tonic-clonic seizures (HP:0002069)2.87763160
27Joint hemorrhage (HP:0005261)2.86581786
28Limb dystonia (HP:0002451)2.85262158
29Febrile seizures (HP:0002373)2.83704982
30Hyperglycinemia (HP:0002154)2.80782533
31Genetic anticipation (HP:0003743)2.71338278
32Impaired social interactions (HP:0000735)2.69210499
33Abnormal social behavior (HP:0012433)2.69210499
34Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.68165872
35Dialeptic seizures (HP:0011146)2.68116785
36Fat malabsorption (HP:0002630)2.67905525
37Volvulus (HP:0002580)2.65480085
38Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.65122046
39Abnormality of complement system (HP:0005339)2.64656623
40Poor eye contact (HP:0000817)2.61532459
41Hyperammonemia (HP:0001987)2.61532405
42Protruding tongue (HP:0010808)2.60268807
43Ketoacidosis (HP:0001993)2.56247008
44Abnormality of glutamine family amino acid metabolism (HP:0010902)2.52258525
45Hypoalphalipoproteinemia (HP:0003233)2.50560168
46Abnormality of sulfur amino acid metabolism (HP:0004339)2.48987396
47Epileptiform EEG discharges (HP:0011182)2.48701356
48Dysdiadochokinesis (HP:0002075)2.48642515
49Cerebral inclusion bodies (HP:0100314)2.47038391
50Widely spaced teeth (HP:0000687)2.46746927
51Absent speech (HP:0001344)2.45501818
52EEG with generalized epileptiform discharges (HP:0011198)2.44568933
53Action tremor (HP:0002345)2.44502735
54Chronic hepatic failure (HP:0100626)2.44035708
55Menstrual irregularities (HP:0000858)2.43898720
56Papillary thyroid carcinoma (HP:0002895)2.43722173
57Abnormality of methionine metabolism (HP:0010901)2.43627296
58Scanning speech (HP:0002168)2.43446733
59Abnormal gallbladder physiology (HP:0012438)2.42856121
60Cholecystitis (HP:0001082)2.42856121
61Abnormality of aspartate family amino acid metabolism (HP:0010899)2.42667226
62Papilledema (HP:0001085)2.39053073
63Fair hair (HP:0002286)2.38460257
64Abnormality of the lower motor neuron (HP:0002366)2.38170041
65Abnormality of the intrinsic pathway (HP:0010989)2.38069545
66Hypsarrhythmia (HP:0002521)2.36520532
67Pheochromocytoma (HP:0002666)2.36484769
68Spontaneous abortion (HP:0005268)2.35713202
69Gaze-evoked nystagmus (HP:0000640)2.34881048
70Excessive salivation (HP:0003781)2.34253277
71Drooling (HP:0002307)2.34253277
72Neonatal onset (HP:0003623)2.33348733
73Broad-based gait (HP:0002136)2.32848403
74Short chin (HP:0000331)2.32599309
75Stomach cancer (HP:0012126)2.31603173
76Morphological abnormality of the pyramidal tract (HP:0002062)2.31034220
77Neoplasm of the adrenal cortex (HP:0100641)2.30951796
78Skin nodule (HP:0200036)2.30770256
79Abnormal pancreas size (HP:0012094)2.28769328
80Subacute progressive viral hepatitis (HP:0006572)2.28543625
81Abnormality of ocular smooth pursuit (HP:0000617)2.25608228
82Neurofibrillary tangles (HP:0002185)2.25447380
83Supranuclear gaze palsy (HP:0000605)2.21914291
84Hypochromic microcytic anemia (HP:0004840)2.21773159
85Blue irides (HP:0000635)2.21372301
86Generalized myoclonic seizures (HP:0002123)2.19606505
87Impaired vibration sensation in the lower limbs (HP:0002166)2.19410529
88Torticollis (HP:0000473)2.17387345
89Increased CSF protein (HP:0002922)2.16278543
90Hypoglycemic coma (HP:0001325)2.15582894
91Hemiparesis (HP:0001269)2.14295639
92Gout (HP:0001997)2.14013794
93Impaired smooth pursuit (HP:0007772)2.13942335
94Hyperbilirubinemia (HP:0002904)2.13076605
95Sensorimotor neuropathy (HP:0007141)2.13034976
96Hypercholesterolemia (HP:0003124)2.12114419
97Amyotrophic lateral sclerosis (HP:0007354)2.10813787
98Truncal obesity (HP:0001956)2.10192409
99Spastic gait (HP:0002064)2.10036053
100Lissencephaly (HP:0001339)2.09466139
101Dysmetria (HP:0001310)2.09025775
102Generalized hypopigmentation of hair (HP:0011358)2.08921138
103Dyskinesia (HP:0100660)2.08848985
104Aqueductal stenosis (HP:0002410)2.08841352
105Tetraplegia (HP:0002445)2.07720850
106Abnormality of glycine metabolism (HP:0010895)2.07440448
107Abnormality of serine family amino acid metabolism (HP:0010894)2.07440448
108Abnormality of the corticospinal tract (HP:0002492)2.06515190
109Mitral stenosis (HP:0001718)2.06465364
110Intention tremor (HP:0002080)2.06034596
111Anxiety (HP:0000739)2.04052881
112Abnormal gallbladder morphology (HP:0012437)2.04022731
113Impaired vibratory sensation (HP:0002495)2.02794954
114Truncal ataxia (HP:0002078)2.02426046
115Focal dystonia (HP:0004373)2.02206010
116Diplopia (HP:0000651)2.01670168
117Abnormality of binocular vision (HP:0011514)2.01670168
118Neuroendocrine neoplasm (HP:0100634)2.01131330
119Dysmetric saccades (HP:0000641)2.00864251
120Curly hair (HP:0002212)2.00792827
121Craniofacial dystonia (HP:0012179)2.00214052
122Postural instability (HP:0002172)1.99095127
123Depression (HP:0000716)1.99041671
124Urinary bladder sphincter dysfunction (HP:0002839)1.98954847
125Acanthocytosis (HP:0001927)1.98719005
126Agitation (HP:0000713)1.98179487
127Progressive inability to walk (HP:0002505)1.95716107
128Cholelithiasis (HP:0001081)1.95327632
129Tented upper lip vermilion (HP:0010804)1.94488880
130Insidious onset (HP:0003587)1.94023000
131Termporal pattern (HP:0011008)1.94023000
132Hyperinsulinemic hypoglycemia (HP:0000825)1.93280557
133Thickened helices (HP:0000391)1.93224037
134Macroorchidism (HP:0000053)1.91581905
135Muscular hypotonia of the trunk (HP:0008936)1.91268004
136Inability to walk (HP:0002540)1.89796079
137Thyroid carcinoma (HP:0002890)1.87651886
138Hepatoblastoma (HP:0002884)1.86286873
139Oligodactyly (hands) (HP:0001180)1.84923332
140Open mouth (HP:0000194)1.83674945
141Tapered finger (HP:0001182)1.77935711
142T lymphocytopenia (HP:0005403)1.77892065
143Abnormality of the renal cortex (HP:0011035)1.76160955
144Abnormality of salivation (HP:0100755)1.76130316
145Akinesia (HP:0002304)1.75755082
146Gastroesophageal reflux (HP:0002020)1.75682429
147Heterotopia (HP:0002282)1.74166856
148Increased density of long bones (HP:0006392)1.73620336
149Stomatitis (HP:0010280)1.71654302
150Renal cortical cysts (HP:0000803)1.70979007
151Intellectual disability, progressive (HP:0006887)1.69842737
152Abnormality of T cell number (HP:0011839)1.68586454
153Exotropia (HP:0000577)1.68183363
154Gait imbalance (HP:0002141)1.68147121
155Abnormal eating behavior (HP:0100738)1.67184958
156Late onset (HP:0003584)1.66974537
157Postural tremor (HP:0002174)1.66543450
158Intestinal atresia (HP:0011100)1.65801575
159Hamartoma of the eye (HP:0010568)1.64549689
160Large for gestational age (HP:0001520)1.64437216
161Thyroiditis (HP:0100646)1.62445273

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK3.44595479
2MAP3K93.44026344
3MAP3K43.33367213
4DAPK23.26530130
5MARK13.15513601
6MAP2K43.12592608
7NTRK32.87965550
8EPHA42.76380510
9MAP2K72.72927363
10MAP3K122.40943840
11TNIK2.22512685
12MINK12.21018396
13NLK1.86684992
14PAK61.81440304
15NTRK21.69720422
16EPHA31.69014045
17NTRK11.66004307
18CAMKK11.63333446
19GRK51.57589539
20FGFR31.53759582
21KSR21.49478290
22BRD41.47579682
23CAMKK21.47256045
24CDK191.46785257
25DAPK11.45557408
26ERBB41.44021587
27SIK21.41886898
28INSRR1.38125170
29TXK1.36256815
30CSNK1G21.29014050
31PLK21.27907795
32RET1.24723433
33PNCK1.24125422
34CDK51.20431979
35PRKCG1.19914463
36MAP3K21.19801294
37FRK1.18017496
38ERBB31.13935415
39PASK1.08157794
40LATS21.08154182
41STK381.07793618
42MAP3K131.05902138
43FGFR41.05703353
44TAOK31.05144181
45SGK21.02132751
46WNK11.02087924
47FGFR21.00700794
48KSR10.99074734
49CDK120.98847319
50SGK4940.98184891
51SGK2230.98184891
52CCNB10.98178004
53CAMK2A0.96175696
54STK110.95054151
55PRKCH0.94768314
56MAPK130.94290748
57SGK30.91767979
58AKT30.89776625
59BCKDK0.89145880
60SIK10.87482811
61BCR0.85901652
62MAPK120.85171381
63PAK30.81871105
64PHKG10.81833957
65PHKG20.81833957
66GRK60.81520239
67ITK0.80447358
68GRK10.79630970
69MAP3K70.77656789
70PRKCZ0.76902404
71MST40.76479115
72CDK30.76088633
73OXSR10.74329887
74CAMK2G0.73015220
75EIF2AK30.72993681
76MAP3K10.72155522
77TYRO30.71944332
78STK390.71646865
79CAMK2B0.69220744
80CAMK1G0.68015109
81FES0.67788295
82CSNK1G30.67723255
83ARAF0.66993709
84YES10.63957060
85UHMK10.63566569
86MAP3K60.62776029
87PKN10.62729359
88MAPK70.62587458
89PDK10.62548169
90PDPK10.61701760
91DYRK1A0.61637434
92HIPK20.61630778
93PINK10.61077421
94CDK150.60617299
95CDK180.60223644
96CAMK10.59694012
97MAP4K10.59650190
98TAOK10.58023849
99RIPK10.56991209
100RIPK40.56986879
101CHUK0.56150610
102CDK140.56117251
103SGK10.55812084
104NEK60.55603635
105PRKD30.51619550
106CDK90.51534287
107ACVR1B0.50100339
108LMTK20.49418715
109JAK20.48983985
110CDK11A0.48534002
111STK240.48054430
112SCYL20.46489758
113RPS6KA30.45245796
114CSNK1G10.45200922
115CSNK1D0.44814187
116CAMK40.44090683
117SIK30.43606737
118CSNK1A1L0.43446373
119FER0.42950016
120CAMK2D0.42398614
121ERN10.41689046
122WNK30.41411502
123JAK10.41128446
124LCK0.40539245
125MAPK40.40529471
126ADRBK20.40330263
127PRKACG0.40255736
128MAP3K50.40235908
129FYN0.40209556
130PRKCE0.40165965
131IRAK10.40132276
132DYRK30.40063028
133MAP3K140.39958944
134IRAK20.39220311
135MARK20.38209488
136IKBKE0.35874052
137TNK20.35770834
138PRKAA10.34744142
139STK38L0.34171369

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.68686007
2Primary bile acid biosynthesis_Homo sapiens_hsa001203.67846827
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.35063244
4Arginine biosynthesis_Homo sapiens_hsa002202.71642077
5Synaptic vesicle cycle_Homo sapiens_hsa047212.23092586
6Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.11818100
7Butanoate metabolism_Homo sapiens_hsa006502.11800550
8Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.09652742
9Nicotine addiction_Homo sapiens_hsa050332.08959404
10Complement and coagulation cascades_Homo sapiens_hsa046101.96913407
11Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.90072853
12Tryptophan metabolism_Homo sapiens_hsa003801.88437868
13Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.86439207
14Bile secretion_Homo sapiens_hsa049761.69102320
15Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.68048072
16Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.59749908
17GABAergic synapse_Homo sapiens_hsa047271.59181795
18Dorso-ventral axis formation_Homo sapiens_hsa043201.44338347
19Fatty acid degradation_Homo sapiens_hsa000711.43838606
20Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.41976236
21Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.39726277
22Inositol phosphate metabolism_Homo sapiens_hsa005621.39004871
23Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.38543461
24T cell receptor signaling pathway_Homo sapiens_hsa046601.38536885
25Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.38311931
26Amphetamine addiction_Homo sapiens_hsa050311.30614312
27Peroxisome_Homo sapiens_hsa041461.29470938
28Phenylalanine metabolism_Homo sapiens_hsa003601.26296730
29Glutamatergic synapse_Homo sapiens_hsa047241.25419207
30Long-term potentiation_Homo sapiens_hsa047201.21696680
31Prolactin signaling pathway_Homo sapiens_hsa049171.18470883
32Histidine metabolism_Homo sapiens_hsa003401.18042180
33Insulin secretion_Homo sapiens_hsa049111.17798603
34PPAR signaling pathway_Homo sapiens_hsa033201.16265791
35Circadian entrainment_Homo sapiens_hsa047131.15458232
36Fatty acid metabolism_Homo sapiens_hsa012121.14432700
37Steroid hormone biosynthesis_Homo sapiens_hsa001401.12631505
38Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.11651166
39ErbB signaling pathway_Homo sapiens_hsa040121.11634732
40Morphine addiction_Homo sapiens_hsa050321.10278366
41Propanoate metabolism_Homo sapiens_hsa006401.09960807
42Tyrosine metabolism_Homo sapiens_hsa003501.08993664
43Dopaminergic synapse_Homo sapiens_hsa047281.08674362
44FoxO signaling pathway_Homo sapiens_hsa040681.07204157
45Cocaine addiction_Homo sapiens_hsa050301.06812192
46Pyruvate metabolism_Homo sapiens_hsa006201.05858830
47Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.03064702
48Maturity onset diabetes of the young_Homo sapiens_hsa049501.02818564
49Retinol metabolism_Homo sapiens_hsa008301.00635508
50beta-Alanine metabolism_Homo sapiens_hsa004101.00572467
51Pentose and glucuronate interconversions_Homo sapiens_hsa000400.99966740
52Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.99085397
53mTOR signaling pathway_Homo sapiens_hsa041500.98893316
542-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.97449309
55Chemical carcinogenesis_Homo sapiens_hsa052040.96600603
56Renal cell carcinoma_Homo sapiens_hsa052110.95978637
57Endometrial cancer_Homo sapiens_hsa052130.95415546
58Aldosterone synthesis and secretion_Homo sapiens_hsa049250.94860411
59Sulfur metabolism_Homo sapiens_hsa009200.94742170
60ABC transporters_Homo sapiens_hsa020100.94285499
61Colorectal cancer_Homo sapiens_hsa052100.93921253
62Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.92828723
63Salivary secretion_Homo sapiens_hsa049700.92200356
64Taste transduction_Homo sapiens_hsa047420.89232166
65Olfactory transduction_Homo sapiens_hsa047400.89054514
66Axon guidance_Homo sapiens_hsa043600.88958314
67Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.87977137
68Neurotrophin signaling pathway_Homo sapiens_hsa047220.87721507
69Pancreatic secretion_Homo sapiens_hsa049720.86750159
70Staphylococcus aureus infection_Homo sapiens_hsa051500.86447826
71Caffeine metabolism_Homo sapiens_hsa002320.84239887
72Sphingolipid signaling pathway_Homo sapiens_hsa040710.83627204
73Cysteine and methionine metabolism_Homo sapiens_hsa002700.83390131
74MAPK signaling pathway_Homo sapiens_hsa040100.82867160
75Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.82721029
76Regulation of autophagy_Homo sapiens_hsa041400.82514795
77Ras signaling pathway_Homo sapiens_hsa040140.81666687
78Glioma_Homo sapiens_hsa052140.81400981
79Cholinergic synapse_Homo sapiens_hsa047250.79405452
80Collecting duct acid secretion_Homo sapiens_hsa049660.78970829
81Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.77986047
82Ether lipid metabolism_Homo sapiens_hsa005650.76729600
83Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.76421380
84Starch and sucrose metabolism_Homo sapiens_hsa005000.76222656
85Phototransduction_Homo sapiens_hsa047440.76024443
86cGMP-PKG signaling pathway_Homo sapiens_hsa040220.75930458
87Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.75431383
88Fatty acid elongation_Homo sapiens_hsa000620.75279412
89Drug metabolism - other enzymes_Homo sapiens_hsa009830.73919142
90Thyroid hormone signaling pathway_Homo sapiens_hsa049190.72999609
91Sphingolipid metabolism_Homo sapiens_hsa006000.72743716
92Choline metabolism in cancer_Homo sapiens_hsa052310.72309565
93Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.71884632
94Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.71301179
95Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.71138031
96Non-small cell lung cancer_Homo sapiens_hsa052230.70684222
97Type II diabetes mellitus_Homo sapiens_hsa049300.70064602
98Renin secretion_Homo sapiens_hsa049240.69608303
99Prion diseases_Homo sapiens_hsa050200.69307078
100Gastric acid secretion_Homo sapiens_hsa049710.69184726
101Longevity regulating pathway - mammal_Homo sapiens_hsa042110.68893014
102Serotonergic synapse_Homo sapiens_hsa047260.67768457
103Long-term depression_Homo sapiens_hsa047300.66939552
104Fat digestion and absorption_Homo sapiens_hsa049750.66339196
105Phospholipase D signaling pathway_Homo sapiens_hsa040720.66175300
106Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.65919332
107Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.64789011
108Cyanoamino acid metabolism_Homo sapiens_hsa004600.61100343
109Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.59267297
110Glucagon signaling pathway_Homo sapiens_hsa049220.59121700
111Melanogenesis_Homo sapiens_hsa049160.58809699
112Rap1 signaling pathway_Homo sapiens_hsa040150.58015870
113Biosynthesis of amino acids_Homo sapiens_hsa012300.57650586
114Vascular smooth muscle contraction_Homo sapiens_hsa042700.56717521
115RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.56284455
116Chemokine signaling pathway_Homo sapiens_hsa040620.56121515
117Jak-STAT signaling pathway_Homo sapiens_hsa046300.55503666
118VEGF signaling pathway_Homo sapiens_hsa043700.54778065
119Oxytocin signaling pathway_Homo sapiens_hsa049210.54238475
120Selenocompound metabolism_Homo sapiens_hsa004500.53259091
121Glycerolipid metabolism_Homo sapiens_hsa005610.51889267
122Fatty acid biosynthesis_Homo sapiens_hsa000610.51294304
123Ovarian steroidogenesis_Homo sapiens_hsa049130.51214600
124Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.50677133
125Calcium signaling pathway_Homo sapiens_hsa040200.50224732
126Carbon metabolism_Homo sapiens_hsa012000.48790921
127B cell receptor signaling pathway_Homo sapiens_hsa046620.48175339
128Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.48110996
129Alcoholism_Homo sapiens_hsa050340.47669769
130Hepatitis C_Homo sapiens_hsa051600.47621315
131NOD-like receptor signaling pathway_Homo sapiens_hsa046210.47283535
132GnRH signaling pathway_Homo sapiens_hsa049120.46666681
133Estrogen signaling pathway_Homo sapiens_hsa049150.46513155
134Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.45177070
135AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.43803469
136Pancreatic cancer_Homo sapiens_hsa052120.43492769
137Insulin resistance_Homo sapiens_hsa049310.42816195
138Steroid biosynthesis_Homo sapiens_hsa001000.42741746
139Thyroid hormone synthesis_Homo sapiens_hsa049180.42168874
140Vitamin B6 metabolism_Homo sapiens_hsa007500.42153872
141Circadian rhythm_Homo sapiens_hsa047100.41908379
142cAMP signaling pathway_Homo sapiens_hsa040240.38503405
143Gap junction_Homo sapiens_hsa045400.38178422
144Phosphatidylinositol signaling system_Homo sapiens_hsa040700.38054531
145Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.36137723
146Carbohydrate digestion and absorption_Homo sapiens_hsa049730.32869230
147Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.32467504
148Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.32069544
149Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.31741775

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