PLCXD3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.93350879
2regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO4.81279295
3phenol-containing compound catabolic process (GO:0019336)4.67359628
4regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)4.54151672
5synaptic vesicle exocytosis (GO:0016079)4.51197267
6neuron cell-cell adhesion (GO:0007158)4.44726222
7regulation of type B pancreatic cell apoptotic process (GO:2000674)4.17258740
8negative regulation of cytosolic calcium ion concentration (GO:0051481)4.14727184
9negative regulation of hormone biosynthetic process (GO:0032353)4.09210378
10cell communication by electrical coupling (GO:0010644)4.05128113
11dopamine biosynthetic process (GO:0042416)4.00511855
12regulation of synaptic vesicle exocytosis (GO:2000300)3.95293208
13mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.94631684
14positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.93117432
15relaxation of cardiac muscle (GO:0055119)3.87199054
16regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.86771002
17energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.80894585
18ATP hydrolysis coupled proton transport (GO:0015991)3.80894585
19neuronal action potential propagation (GO:0019227)3.77956756
20cell communication involved in cardiac conduction (GO:0086065)3.74739948
21catecholamine transport (GO:0051937)3.72913563
22positive regulation of glycolytic process (GO:0045821)3.71376499
23positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.65896736
24cardiac myofibril assembly (GO:0055003)3.63943317
25regulation of short-term neuronal synaptic plasticity (GO:0048172)3.62582743
26positive regulation of synaptic transmission, GABAergic (GO:0032230)3.59806397
27transferrin transport (GO:0033572)3.59580259
28behavioral response to ethanol (GO:0048149)3.59066651
29behavioral response to nicotine (GO:0035095)3.58997666
30detection of calcium ion (GO:0005513)3.56160940
31vocalization behavior (GO:0071625)3.55382399
32myofibril assembly (GO:0030239)3.54473630
33chaperone-mediated protein transport (GO:0072321)3.52877062
34mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.52825035
35synaptic vesicle maturation (GO:0016188)3.52332637
36regulation of cell communication by electrical coupling (GO:0010649)3.52088475
37negative regulation of hormone metabolic process (GO:0032351)3.51497465
38regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.46958950
39proline transport (GO:0015824)3.46894859
40cardiac conduction (GO:0061337)3.43790673
41presynaptic membrane assembly (GO:0097105)3.41470071
42dopamine transport (GO:0015872)3.41222552
43neurotransmitter secretion (GO:0007269)3.39585972
44glutamate secretion (GO:0014047)3.39272324
45regulation of synaptic vesicle transport (GO:1902803)3.36471428
46energy coupled proton transport, down electrochemical gradient (GO:0015985)3.35471105
47ATP synthesis coupled proton transport (GO:0015986)3.35471105
48trivalent inorganic cation transport (GO:0072512)3.34895978
49ferric iron transport (GO:0015682)3.34895978
50endocrine pancreas development (GO:0031018)3.32072075
51protein localization to synapse (GO:0035418)3.31884212
52cellular ketone body metabolic process (GO:0046950)3.31045679
53urinary tract smooth muscle contraction (GO:0014848)3.30799700
54positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.30395599
55negative regulation of microtubule polymerization (GO:0031115)3.29118017
56cardiac muscle contraction (GO:0060048)3.29059082
57regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.28287929
58catecholamine biosynthetic process (GO:0042423)3.26947673
59catechol-containing compound biosynthetic process (GO:0009713)3.26947673
60protein localization to cilium (GO:0061512)3.24993720
61type B pancreatic cell development (GO:0003323)3.24574548
62nitric oxide mediated signal transduction (GO:0007263)3.23926969
63negative regulation of dendrite morphogenesis (GO:0050774)3.21909007
64regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.21688704
65regulation of actin filament-based movement (GO:1903115)3.21659926
66chemosensory behavior (GO:0007635)3.20791570
67regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.19102401
68regulation of catecholamine metabolic process (GO:0042069)3.18712659
69regulation of dopamine metabolic process (GO:0042053)3.18712659
70glandular epithelial cell differentiation (GO:0002067)3.18090385
71regulation of heart rate by cardiac conduction (GO:0086091)3.14686649
72sarcomere organization (GO:0045214)3.13110493
73dopamine metabolic process (GO:0042417)3.12089573
74dendritic spine morphogenesis (GO:0060997)3.10968117
75neuronal action potential (GO:0019228)3.09926115
76respiratory electron transport chain (GO:0022904)3.09353227
77electron transport chain (GO:0022900)3.08321231
78neurotransmitter transport (GO:0006836)3.07973941
79postsynaptic membrane organization (GO:0001941)3.07632807
80protein neddylation (GO:0045116)3.05665405
81opioid receptor signaling pathway (GO:0038003)3.04784185
82neuron-neuron synaptic transmission (GO:0007270)3.03718129
83regulation of vesicle fusion (GO:0031338)3.02259304
84regulation of heart rate (GO:0002027)3.02035589
85regulation of hexokinase activity (GO:1903299)2.99850143
86regulation of glucokinase activity (GO:0033131)2.99850143
87cardiac muscle hypertrophy (GO:0003300)2.99084802
88positive regulation of amino acid transport (GO:0051957)2.98729365
89presynaptic membrane organization (GO:0097090)2.98612139
90neuron recognition (GO:0008038)2.97914091
91negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.97322162
92regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.97250134
93positive regulation of synapse assembly (GO:0051965)2.96718085
94synaptic vesicle docking involved in exocytosis (GO:0016081)2.94990497
95regulation of cardiac muscle cell contraction (GO:0086004)2.94536385
96regulation of relaxation of muscle (GO:1901077)2.93114102
97negative regulation of synaptic transmission, GABAergic (GO:0032229)2.92435960
98insulin secretion (GO:0030073)2.92146424
99cardiac muscle cell action potential (GO:0086001)2.92126195
100regulation of glutamate receptor signaling pathway (GO:1900449)2.91596910
101response to pain (GO:0048265)2.90411152
102positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.89945964
103regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.89500256
104regulation of the force of heart contraction (GO:0002026)2.88851568
105ketone body metabolic process (GO:1902224)2.87769114
106regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.87653016
107regulation of oxidative phosphorylation (GO:0002082)2.86305571
108regulation of membrane repolarization (GO:0060306)2.86298608
109ventricular cardiac muscle cell action potential (GO:0086005)2.86250450
110synaptic vesicle transport (GO:0048489)2.85376130
111establishment of synaptic vesicle localization (GO:0097480)2.85376130
112neurotransmitter catabolic process (GO:0042135)2.84875207
113synaptic transmission, glutamatergic (GO:0035249)2.84792608
114neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.84496072
115striatum development (GO:0021756)2.84314790
116regulation of neurotransmitter secretion (GO:0046928)2.84031395
117negative regulation of gluconeogenesis (GO:0045721)2.83154132
118regulation of energy homeostasis (GO:2000505)2.83137312
119striated muscle hypertrophy (GO:0014897)2.82706033
120adrenergic receptor signaling pathway (GO:0071875)2.80620262
121cardiac muscle cell action potential involved in contraction (GO:0086002)2.79704864
122sympathetic nervous system development (GO:0048485)2.79330940
123positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.79243631
124adult heart development (GO:0007512)2.78920599
125cAMP-mediated signaling (GO:0019933)2.78638567
126calcium ion import (GO:0070509)2.77801923
127protein complex biogenesis (GO:0070271)2.77382009
128regulation of respiratory system process (GO:0044065)2.76348581
129gamma-aminobutyric acid signaling pathway (GO:0007214)2.75895303
130membrane depolarization during action potential (GO:0086010)2.75705644
131neuromuscular process controlling posture (GO:0050884)2.75691965
132peptide hormone secretion (GO:0030072)2.74770110
133cellular potassium ion homeostasis (GO:0030007)2.74547950
134multicellular organismal signaling (GO:0035637)2.74459281
135positive regulation of sodium ion transport (GO:0010765)2.74427023
136innervation (GO:0060384)2.74272536
137positive regulation of glycogen biosynthetic process (GO:0045725)2.74254446
138membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.73668988
139regulation of neurotransmitter levels (GO:0001505)2.72431774
140regulation of neurotransmitter transport (GO:0051588)2.72028720
141fatty acid homeostasis (GO:0055089)2.71974141
142neuromuscular synaptic transmission (GO:0007274)2.71872970
143phagosome maturation (GO:0090382)2.70668699
144calcium ion-dependent exocytosis (GO:0017156)2.70457302
145regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.70445043
146regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.70445043
147regulation of cardiac muscle contraction (GO:0055117)2.68099807
148ionotropic glutamate receptor signaling pathway (GO:0035235)2.67808065
149synapse assembly (GO:0007416)2.67756983
150regulation of synaptic transmission, GABAergic (GO:0032228)2.67474349
151cell migration in hindbrain (GO:0021535)2.67454112
152peptide secretion (GO:0002790)2.65632840
153positive regulation of heart rate (GO:0010460)2.65539215
154response to histamine (GO:0034776)2.65154861
155membrane hyperpolarization (GO:0060081)2.64429599
156membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.64388436
157regulation of sarcomere organization (GO:0060297)2.64308049
158regulation of respiratory gaseous exchange (GO:0043576)2.64149460
159establishment of vesicle localization (GO:0051650)2.61935540
160positive regulation of insulin secretion (GO:0032024)2.61861551
161positive regulation of neurotransmitter transport (GO:0051590)2.60740811
162sodium ion export (GO:0071436)2.60505120
163positive regulation of exocytosis (GO:0045921)2.60421660
164regulation of striated muscle contraction (GO:0006942)2.58557731
165bundle of His cell to Purkinje myocyte communication (GO:0086069)2.55448222
166positive regulation of peptide hormone secretion (GO:0090277)2.54352973
167positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.53872051
168action potential (GO:0001508)2.52663507
169positive regulation of action potential (GO:0045760)2.52519540
170righting reflex (GO:0060013)2.51605701
171epithelial cell fate commitment (GO:0072148)2.49540748
172positive regulation of peptide secretion (GO:0002793)2.48999649
173positive regulation of synapse maturation (GO:0090129)2.48833477
174relaxation of muscle (GO:0090075)2.47653342
175ventricular cardiac muscle tissue morphogenesis (GO:0055010)2.47622101
176cellular sodium ion homeostasis (GO:0006883)2.46695354
177embryonic retina morphogenesis in camera-type eye (GO:0060059)2.44283029
178glutamate receptor signaling pathway (GO:0007215)2.44094126
179muscle hypertrophy (GO:0014896)2.43128639
180regulation of heart contraction (GO:0008016)2.43072367
181regulation of insulin secretion (GO:0050796)2.42217239
182regulation of action potential (GO:0098900)2.39001280
183positive regulation of glycogen metabolic process (GO:0070875)2.38511408
184response to dietary excess (GO:0002021)2.36824122
185potassium ion homeostasis (GO:0055075)2.35258427
186striated muscle contraction (GO:0006941)2.35156575

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.29797231
2GBX2_23144817_ChIP-Seq_PC3_Human4.04276590
3TAF15_26573619_Chip-Seq_HEK293_Human2.80651532
4* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.69658000
5BMI1_23680149_ChIP-Seq_NPCS_Mouse2.55421162
6EZH2_27304074_Chip-Seq_ESCs_Mouse2.47465511
7* REST_21632747_ChIP-Seq_MESCs_Mouse2.44903147
8CTBP2_25329375_ChIP-Seq_LNCAP_Human2.44334682
9* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.43493730
10JARID2_20064375_ChIP-Seq_MESCs_Mouse2.43200593
11NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.39079501
12ZFP57_27257070_Chip-Seq_ESCs_Mouse2.35018372
13JARID2_20075857_ChIP-Seq_MESCs_Mouse2.28224345
14SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.27799229
15GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.27537477
16IGF1R_20145208_ChIP-Seq_DFB_Human2.16967345
17SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.16709340
18TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.14068476
19* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.12214012
20EED_16625203_ChIP-ChIP_MESCs_Mouse2.06955855
21VDR_22108803_ChIP-Seq_LS180_Human2.06255204
22CTBP1_25329375_ChIP-Seq_LNCAP_Human2.04894919
23* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.04830037
24EZH2_18974828_ChIP-Seq_MESCs_Mouse2.01013417
25RNF2_18974828_ChIP-Seq_MESCs_Mouse2.01013417
26POU3F2_20337985_ChIP-ChIP_501MEL_Human1.96948197
27P300_19829295_ChIP-Seq_ESCs_Human1.96928795
28REST_18959480_ChIP-ChIP_MESCs_Mouse1.95477347
29* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.91327187
30CBX2_27304074_Chip-Seq_ESCs_Mouse1.88058984
31PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.87311077
32FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.87097758
33GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.86797629
34EZH2_27294783_Chip-Seq_ESCs_Mouse1.85444605
35SUZ12_27294783_Chip-Seq_ESCs_Mouse1.83431843
36CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.80572575
37* SMAD4_21799915_ChIP-Seq_A2780_Human1.77509906
38ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.76307158
39PIAS1_25552417_ChIP-Seq_VCAP_Human1.68290821
40RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.67954498
41NR3C1_23031785_ChIP-Seq_PC12_Mouse1.67738913
42RNF2_27304074_Chip-Seq_NSC_Mouse1.67357810
43ZNF274_21170338_ChIP-Seq_K562_Hela1.67223348
44RNF2_27304074_Chip-Seq_ESCs_Mouse1.65989328
45EP300_21415370_ChIP-Seq_HL-1_Mouse1.61021620
46* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.59827809
47IKZF1_21737484_ChIP-ChIP_HCT116_Human1.57365794
48PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.56335549
49AR_21572438_ChIP-Seq_LNCaP_Human1.49404680
50OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.44537443
51FUS_26573619_Chip-Seq_HEK293_Human1.42114155
52AR_25329375_ChIP-Seq_VCAP_Human1.41105003
53PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.36204538
54DROSHA_22980978_ChIP-Seq_HELA_Human1.35660445
55SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.34310965
56ZNF217_24962896_ChIP-Seq_MCF-7_Human1.33902558
57* SMAD3_21741376_ChIP-Seq_EPCs_Human1.33312195
58ER_23166858_ChIP-Seq_MCF-7_Human1.33109211
59NANOG_18555785_Chip-Seq_ESCs_Mouse1.31778621
60* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.30416254
61RBPJ_22232070_ChIP-Seq_NCS_Mouse1.27051785
62RUNX2_22187159_ChIP-Seq_PCA_Human1.25187177
63SOX2_21211035_ChIP-Seq_LN229_Gbm1.24843197
64NR3C1_21868756_ChIP-Seq_MCF10A_Human1.24317981
65* STAT3_23295773_ChIP-Seq_U87_Human1.23778913
66* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.23512977
67TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.23233222
68* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.23023769
69EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.22054222
70SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.21609573
71MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.21585689
72PCGF2_27294783_Chip-Seq_ESCs_Mouse1.21032735
73SMAD3_21741376_ChIP-Seq_HESCs_Human1.20306482
74EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.19402229
75RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.18412332
76TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.18052731
77WT1_25993318_ChIP-Seq_PODOCYTE_Human1.17453139
78SMAD4_21741376_ChIP-Seq_HESCs_Human1.16971257
79RARB_27405468_Chip-Seq_BRAIN_Mouse1.16969800
80FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.16594313
81FLI1_27457419_Chip-Seq_LIVER_Mouse1.16443170
82ARNT_22903824_ChIP-Seq_MCF-7_Human1.16111971
83CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15775172
84JUN_21703547_ChIP-Seq_K562_Human1.15479166
85BCAT_22108803_ChIP-Seq_LS180_Human1.13484564
86BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.12776068
87P53_22387025_ChIP-Seq_ESCs_Mouse1.11652048
88RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.11416200
89TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.09252809
90* TCF4_23295773_ChIP-Seq_U87_Human1.09140271
91ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.08973940
92CBP_20019798_ChIP-Seq_JUKART_Human1.06834524
93IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.06834524
94RING1B_27294783_Chip-Seq_ESCs_Mouse1.06438187
95CMYC_18555785_Chip-Seq_ESCs_Mouse1.06317442
96E2F1_18555785_Chip-Seq_ESCs_Mouse1.06209069
97AHR_22903824_ChIP-Seq_MCF-7_Human1.05917346
98* SMAD4_21741376_ChIP-Seq_EPCs_Human1.04706488
99STAT3_18555785_Chip-Seq_ESCs_Mouse1.03376771
100TBL1_22424771_ChIP-Seq_293T_Human1.03359617
101KDM2B_26808549_Chip-Seq_REH_Human1.03336622
102TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02780302
103PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.02610559
104SUZ12_18555785_Chip-Seq_ESCs_Mouse1.02482962
105SUZ12_27294783_Chip-Seq_NPCs_Mouse1.02286758
106* AR_19668381_ChIP-Seq_PC3_Human1.01897340
107ERG_21242973_ChIP-ChIP_JURKAT_Human1.01688409
108PRDM14_20953172_ChIP-Seq_ESCs_Human1.01150194
109SOX2_18555785_Chip-Seq_ESCs_Mouse1.00359291
110CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.98854256
111CDX2_19796622_ChIP-Seq_MESCs_Mouse0.98678108
112SMAD_19615063_ChIP-ChIP_OVARY_Human0.97391236
113REST_19997604_ChIP-ChIP_NEURONS_Mouse0.97080502
114NMYC_18555785_Chip-Seq_ESCs_Mouse0.96729897
115EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.95823015
116TAL1_26923725_Chip-Seq_HPCs_Mouse0.95252740
117LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94753565
118CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.94609412
119RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.93917086
120MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.93135859
121P300_18555785_Chip-Seq_ESCs_Mouse0.93118090
122TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93045371
123POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.93045371

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern3.76316464
2MP0006276_abnormal_autonomic_nervous3.34136469
3MP0001968_abnormal_touch/_nociception3.25778551
4MP0004270_analgesia3.22984274
5MP0010386_abnormal_urinary_bladder3.15413357
6MP0002735_abnormal_chemical_nociception3.00809787
7MP0002736_abnormal_nociception_after2.97049882
8MP0003122_maternal_imprinting2.96461083
9MP0004215_abnormal_myocardial_fiber2.89669869
10MP0002734_abnormal_mechanical_nocicepti2.88444482
11MP0004084_abnormal_cardiac_muscle2.82334763
12MP0004859_abnormal_synaptic_plasticity2.76782768
13MP0003635_abnormal_synaptic_transmissio2.75201616
14MP0002822_catalepsy2.66217328
15MP0001529_abnormal_vocalization2.63881056
16MP0002733_abnormal_thermal_nociception2.58483437
17MP0009745_abnormal_behavioral_response2.57425769
18MP0004510_myositis2.51254071
19MP0002064_seizures2.39999129
20MP0002638_abnormal_pupillary_reflex2.34960768
21MP0009046_muscle_twitch2.34292001
22MP0002572_abnormal_emotion/affect_behav2.33471519
23MP0001970_abnormal_pain_threshold2.32821829
24MP0001905_abnormal_dopamine_level2.26874993
25MP0002272_abnormal_nervous_system2.21591785
26MP0002063_abnormal_learning/memory/cond2.20598886
27MP0005645_abnormal_hypothalamus_physiol2.20361510
28MP0005646_abnormal_pituitary_gland2.11828703
29MP0001440_abnormal_grooming_behavior2.09590407
30MP0004036_abnormal_muscle_relaxation2.04059629
31MP0002837_dystrophic_cardiac_calcinosis2.03120788
32MP0002067_abnormal_sensory_capabilities1.95889083
33MP0002184_abnormal_innervation1.94998299
34MP0003787_abnormal_imprinting1.92037587
35MP0004145_abnormal_muscle_electrophysio1.91176582
36MP0001501_abnormal_sleep_pattern1.83760985
37MP0001188_hyperpigmentation1.81535783
38MP0005379_endocrine/exocrine_gland_phen1.78561625
39MP0001986_abnormal_taste_sensitivity1.76381320
40MP0002909_abnormal_adrenal_gland1.76179125
41MP0008775_abnormal_heart_ventricle1.75629385
42MP0004924_abnormal_behavior1.75529401
43MP0005386_behavior/neurological_phenoty1.75529401
44MP0005423_abnormal_somatic_nervous1.74779650
45MP0002557_abnormal_social/conspecific_i1.69577388
46MP0001486_abnormal_startle_reflex1.69564850
47MP0003137_abnormal_impulse_conducting1.68629500
48MP0000013_abnormal_adipose_tissue1.68049396
49MP0001984_abnormal_olfaction1.67640197
50MP0003183_abnormal_peptide_metabolism1.66955020
51MP0009780_abnormal_chondrocyte_physiolo1.66166232
52MP0002751_abnormal_autonomic_nervous1.62214244
53MP0002876_abnormal_thyroid_physiology1.59136341
54MP0000778_abnormal_nervous_system1.54749048
55MP0004142_abnormal_muscle_tone1.53185613
56MP0002163_abnormal_gland_morphology1.48026028
57MP0006072_abnormal_retinal_apoptosis1.42575340
58MP0006292_abnormal_olfactory_placode1.37951462
59MP0003879_abnormal_hair_cell1.35780037
60MP0002972_abnormal_cardiac_muscle1.32266557
61MP0003121_genomic_imprinting1.26814244
62MP0001502_abnormal_circadian_rhythm1.25102591
63MP0000538_abnormal_urinary_bladder1.24979064
64MP0005330_cardiomyopathy1.23775185
65MP0000631_abnormal_neuroendocrine_gland1.23471317
66MP0003045_fibrosis1.22807055
67MP0000955_abnormal_spinal_cord1.21405314
68MP0000569_abnormal_digit_pigmentation1.19578828
69MP0004811_abnormal_neuron_physiology1.19561571
70MP0005394_taste/olfaction_phenotype1.16608811
71MP0005499_abnormal_olfactory_system1.16608811
72MP0002882_abnormal_neuron_morphology1.13469929
73MP0005620_abnormal_muscle_contractility1.12893907
74MP0002066_abnormal_motor_capabilities/c1.11665000
75MP0004484_altered_response_of1.11614906
76MP0008569_lethality_at_weaning1.11281373
77MP0002693_abnormal_pancreas_physiology1.10869586
78MP0000462_abnormal_digestive_system1.10580840
79MP0004885_abnormal_endolymph1.09935445
80MP0005220_abnormal_exocrine_pancreas1.05322546
81MP0004858_abnormal_nervous_system1.04221270
82MP0008789_abnormal_olfactory_epithelium1.01189011
83MP0005535_abnormal_body_temperature1.00471005
84MP0001944_abnormal_pancreas_morphology0.97706668
85MP0004043_abnormal_pH_regulation0.96949107
86MP0004742_abnormal_vestibular_system0.94874178
87MP0001485_abnormal_pinna_reflex0.94306578
88MP0002127_abnormal_cardiovascular_syste0.92428607
89MP0000639_abnormal_adrenal_gland0.90831826
90MP0001765_abnormal_ion_homeostasis0.90597341
91MP0008004_abnormal_stomach_pH0.88576956
92MP0005551_abnormal_eye_electrophysiolog0.88256990
93MP0008872_abnormal_physiological_respon0.87801751
94MP0002928_abnormal_bile_duct0.87511859
95MP0002069_abnormal_eating/drinking_beha0.87233989
96MP0003195_calcinosis0.86426984
97MP0005448_abnormal_energy_balance0.85748037
98MP0001664_abnormal_digestion0.85676792
99MP0003646_muscle_fatigue0.84079766
100MP0002102_abnormal_ear_morphology0.83738138
101MP0010329_abnormal_lipoprotein_level0.83726400
102MP0005670_abnormal_white_adipose0.82822214
103MP0008877_abnormal_DNA_methylation0.82336373
104MP0003283_abnormal_digestive_organ0.82177504
105MP0001963_abnormal_hearing_physiology0.81569627
106MP0001544_abnormal_cardiovascular_syste0.80168133
107MP0005385_cardiovascular_system_phenoty0.80168133
108MP0003633_abnormal_nervous_system0.78632017
109MP0002752_abnormal_somatic_nervous0.78609168
110MP0002106_abnormal_muscle_physiology0.77782233
111MP0005410_abnormal_fertilization0.77511682
112MP0002229_neurodegeneration0.76426458
113MP0002152_abnormal_brain_morphology0.76282191
114MP0004085_abnormal_heartbeat0.73809322
115MP0000678_abnormal_parathyroid_gland0.73279728
116MP0000751_myopathy0.69510879
117MP0003953_abnormal_hormone_level0.68070456
118MP0002078_abnormal_glucose_homeostasis0.67854513
119MP0005253_abnormal_eye_physiology0.65160088
120MP0003631_nervous_system_phenotype0.64494012
121MP0000372_irregular_coat_pigmentation0.62441847
122MP0000026_abnormal_inner_ear0.62064591
123MP0002653_abnormal_ependyma_morphology0.62005280
124MP0006035_abnormal_mitochondrial_morpho0.60880050
125MP0000681_abnormal_thyroid_gland0.60436303
126MP0002938_white_spotting0.60240487
127MP0003329_amyloid_beta_deposits0.56910402
128MP0003123_paternal_imprinting0.56668045
129MP0002277_abnormal_respiratory_mucosa0.54420124
130MP0005084_abnormal_gallbladder_morpholo0.54135257
131MP0002090_abnormal_vision0.53893235

Predicted human phenotypes

RankGene SetZ-score
1Hypothermia (HP:0002045)5.63337631
2Focal motor seizures (HP:0011153)5.25576540
3Hypoglycemic coma (HP:0001325)4.93885144
4Bundle branch block (HP:0011710)4.87179309
5Sudden death (HP:0001699)4.66619026
6Hyperglycemia (HP:0003074)4.54851155
7Limb dystonia (HP:0002451)4.51647762
8Atonic seizures (HP:0010819)4.39708760
9Syncope (HP:0001279)4.38646437
10Ketoacidosis (HP:0001993)4.23496668
11Acute necrotizing encephalopathy (HP:0006965)4.21890026
12Atrial fibrillation (HP:0005110)4.08163863
13Myokymia (HP:0002411)4.07953411
14Febrile seizures (HP:0002373)4.02264657
15Pheochromocytoma (HP:0002666)3.98970396
16Abnormal mitochondria in muscle tissue (HP:0008316)3.94120825
17Focal seizures (HP:0007359)3.86232137
18Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.81456448
19Visual hallucinations (HP:0002367)3.78518532
20Ventricular fibrillation (HP:0001663)3.78379961
21Congenital malformation of the right heart (HP:0011723)3.77118792
22Double outlet right ventricle (HP:0001719)3.77118792
23Progressive macrocephaly (HP:0004481)3.74723949
24Primary atrial arrhythmia (HP:0001692)3.72715329
25Neuroendocrine neoplasm (HP:0100634)3.69563404
26Failure to thrive in infancy (HP:0001531)3.56113879
27Epileptic encephalopathy (HP:0200134)3.52899694
28Supraventricular tachycardia (HP:0004755)3.51340529
29Agitation (HP:0000713)3.43997058
30Insulin-resistant diabetes mellitus (HP:0000831)3.42284488
31Mitochondrial inheritance (HP:0001427)3.40701366
32Supraventricular arrhythmia (HP:0005115)3.40569197
33Absence seizures (HP:0002121)3.36488777
34Ventricular tachycardia (HP:0004756)3.33613053
35Abnormality of endocrine pancreas physiology (HP:0012093)3.32491894
36Abnormality of the pancreatic islet cells (HP:0006476)3.32491894
37Abnormality of calcium-phosphate metabolism (HP:0100530)3.31380594
38Progressive cerebellar ataxia (HP:0002073)3.30265630
39Abnormal pancreas size (HP:0012094)3.28899676
40Abnormal hair whorl (HP:0010721)3.28102072
41Ventricular arrhythmia (HP:0004308)3.21180872
42Late onset (HP:0003584)3.19906040
43Acute encephalopathy (HP:0006846)3.19280259
44Gait imbalance (HP:0002141)3.15917551
45Increased circulating renin level (HP:0000848)3.13935924
46Medial flaring of the eyebrow (HP:0010747)3.11567393
47Generalized tonic-clonic seizures (HP:0002069)3.10317481
48Dialeptic seizures (HP:0011146)3.09655232
49Right ventricular cardiomyopathy (HP:0011663)3.02351881
50Heart block (HP:0012722)2.97983610
51Polyphagia (HP:0002591)2.96919433
52Hemiparesis (HP:0001269)2.92797457
53Amblyopia (HP:0000646)2.91962062
54Prolonged QT interval (HP:0001657)2.87590925
55Congenital primary aphakia (HP:0007707)2.87041161
56Epileptiform EEG discharges (HP:0011182)2.79501143
57Oligomenorrhea (HP:0000876)2.78131394
58Increased CSF lactate (HP:0002490)2.77241962
59Poor suck (HP:0002033)2.76129517
60Abnormality of the calf musculature (HP:0001430)2.75358699
61Nephrogenic diabetes insipidus (HP:0009806)2.75317516
62Abnormal EKG (HP:0003115)2.73800616
63Large for gestational age (HP:0001520)2.73258961
64Decreased circulating renin level (HP:0003351)2.72067941
65EEG with generalized epileptiform discharges (HP:0011198)2.71699200
66Hyperventilation (HP:0002883)2.65430219
67Ketosis (HP:0001946)2.65324663
68Abnormal atrioventricular conduction (HP:0005150)2.62214344
69Symptomatic seizures (HP:0011145)2.62120587
70Abnormal autonomic nervous system physiology (HP:0012332)2.58735815
71Hepatocellular necrosis (HP:0001404)2.52410523
72Hypsarrhythmia (HP:0002521)2.51951037
73Enlarged penis (HP:0000040)2.51160048
74Genital tract atresia (HP:0001827)2.50755146
75Left ventricular hypertrophy (HP:0001712)2.50224124
76Genetic anticipation (HP:0003743)2.49215480
77Anxiety (HP:0000739)2.48313522
78Calf muscle hypertrophy (HP:0008981)2.47283927
79Polydipsia (HP:0001959)2.44458971
80Abnormal drinking behavior (HP:0030082)2.44458971
81Hypoventilation (HP:0002791)2.41880863
82Orthostatic hypotension (HP:0001278)2.41015727
83Vaginal atresia (HP:0000148)2.39528310
84Optic disc pallor (HP:0000543)2.35575670
85Hyperthyroidism (HP:0000836)2.34953863
86Intestinal atresia (HP:0011100)2.33776269
87Progressive inability to walk (HP:0002505)2.33765712
88Abnormality of renin-angiotensin system (HP:0000847)2.32206393
89Hypomagnesemia (HP:0002917)2.31183374
90Hyperinsulinemic hypoglycemia (HP:0000825)2.24034736
91Prominent metopic ridge (HP:0005487)2.21979268
92Dysautonomia (HP:0002459)2.19723394
93Palpitations (HP:0001962)2.16916826
94Exotropia (HP:0000577)2.15690407
95Abnormal eating behavior (HP:0100738)2.15282464
96Aplasia/Hypoplasia of the lens (HP:0008063)2.15146709
97Hypoglycemic seizures (HP:0002173)2.12721702
98Esotropia (HP:0000565)2.11453115
99Truncal ataxia (HP:0002078)2.10640493
100Blue irides (HP:0000635)2.09813269
101Hyperphosphatemia (HP:0002905)2.09765306
102Muscle hypertrophy of the lower extremities (HP:0008968)2.08691473
103Type I diabetes mellitus (HP:0100651)2.08184394
104Abnormality of the metopic suture (HP:0005556)2.08048033
105Abnormality of pain sensation (HP:0010832)2.07709841
106Impaired pain sensation (HP:0007328)2.07709841
107Abnormal pupillary function (HP:0007686)2.07115136
108Protruding tongue (HP:0010808)2.05961840
109Menstrual irregularities (HP:0000858)2.05475128
110Hepatic necrosis (HP:0002605)2.05279379
111Broad-based gait (HP:0002136)2.01924192
112Psychosis (HP:0000709)2.01407729
113Dysmetric saccades (HP:0000641)2.00648258
114Asymmetric septal hypertrophy (HP:0001670)2.00509948
115Abnormal ciliary motility (HP:0012262)1.96365359
116Specific learning disability (HP:0001328)1.96261503
117Increased hepatocellular lipid droplets (HP:0006565)1.96201199
118Hypercortisolism (HP:0001578)1.94014059
119Hyporeflexia of lower limbs (HP:0002600)1.92858258
120Lipoatrophy (HP:0100578)1.92402798
121Depression (HP:0000716)1.91479713
122Dilated cardiomyopathy (HP:0001644)1.90359472
123Testicular neoplasm (HP:0010788)1.90063467
124Poor coordination (HP:0002370)1.89800877
125Hyperkalemia (HP:0002153)1.89637564
126Pancreatic fibrosis (HP:0100732)1.85574536
127Postural tremor (HP:0002174)1.84815918
128Pancreatic islet-cell hyperplasia (HP:0004510)1.83415068
129Atrioventricular block (HP:0001678)1.82750066
130Impaired smooth pursuit (HP:0007772)1.81980366
131Inability to walk (HP:0002540)1.80628236
132Cerebral edema (HP:0002181)1.80320498
133Muscular hypotonia of the trunk (HP:0008936)1.78486147
134Abnormality of magnesium homeostasis (HP:0004921)1.78291009
135Action tremor (HP:0002345)1.78187902
136Aqueductal stenosis (HP:0002410)1.76529481
137Excessive salivation (HP:0003781)1.75920080
138Drooling (HP:0002307)1.75920080
139Hypoplasia of the fovea (HP:0007750)1.75163757
140Aplasia/Hypoplasia of the fovea (HP:0008060)1.75163757
141Delayed gross motor development (HP:0002194)1.74646700
142Subaortic stenosis (HP:0001682)1.74539373
143Abnormality of the left ventricular outflow tract (HP:0011103)1.74539373
144Insulin resistance (HP:0000855)1.74425274
145Dysdiadochokinesis (HP:0002075)1.73772865
146Gaze-evoked nystagmus (HP:0000640)1.73334714
147Exercise intolerance (HP:0003546)1.73113680
148Congenital sensorineural hearing impairment (HP:0008527)1.73084222
149Renal Fanconi syndrome (HP:0001994)1.71793717
150Fetal akinesia sequence (HP:0001989)1.70277859
151Abnormality of the fovea (HP:0000493)1.69833863
152Abnormality of the ischium (HP:0003174)1.69130927
153Bradycardia (HP:0001662)1.68976944
154Retinal dysplasia (HP:0007973)1.68924042
155Aplasia/Hypoplasia of the brainstem (HP:0007362)1.68832005
156Hypoplasia of the brainstem (HP:0002365)1.68832005
157Leukodystrophy (HP:0002415)1.67336599
158Restlessness (HP:0000711)1.67219182
159Lactic acidosis (HP:0003128)1.66602388
160Lipid accumulation in hepatocytes (HP:0006561)1.66587365
161Abnormality of the labia minora (HP:0012880)1.66466072
162Status epilepticus (HP:0002133)1.65044985
163Akinesia (HP:0002304)1.64703359
164Metaphyseal dysplasia (HP:0100255)1.64497027
165Abnormality of ocular smooth pursuit (HP:0000617)1.64306245
166Respiratory failure (HP:0002878)1.63017649
167Abnormal respiratory motile cilium morphology (HP:0005938)1.62990818
168Abnormal respiratory epithelium morphology (HP:0012253)1.62990818

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K124.04380583
2CASK3.90541611
3NTRK33.24716738
4MAP2K73.23346541
5INSRR2.90305863
6MAP3K42.87013162
7MARK12.45697847
8OBSCN2.42339138
9TRIM282.32137071
10MAPK152.30568469
11PINK12.28113586
12GRK52.25908890
13WNK32.23882844
14GRK72.16872776
15MAPK132.04508804
16FGFR22.03203031
17CDK192.01571780
18NTRK11.88668599
19MAP2K41.87291975
20MINK11.85780331
21PLK21.84257129
22NTRK21.79395816
23SIK31.74866167
24AKT31.69331088
25BMPR21.56918181
26BMPR1B1.56754190
27ADRBK21.55107787
28MAP3K91.54083063
29NME11.52595347
30ARAF1.49867031
31STK38L1.49825151
32ERBB31.44944383
33UHMK11.44089392
34PNCK1.31489915
35STK391.27844709
36CAMKK21.25624863
37STK161.24580630
38WNK41.23841305
39CAMK11.23077406
40DMPK1.21922461
41NLK1.19942849
42RIPK41.19316050
43TNIK1.14599684
44OXSR11.14412656
45TRPM71.13390731
46ADRBK11.12744737
47STK381.11666144
48DAPK21.10824261
49SGK2231.10178856
50SGK4941.10178856
51DAPK11.09551052
52BRAF1.09333645
53TSSK61.09210624
54LIMK11.08881845
55BCR1.08165158
56PRPF4B1.06972224
57CAMK2B1.04543486
58SGK21.04501440
59PKN21.04062166
60CDK51.01582210
61GRK10.99472183
62MAP3K20.98752547
63CAMK2A0.98177311
64SGK30.97878039
65PRKCE0.97340080
66ACVR1B0.96947854
67PRKAA10.96358717
68DYRK20.95527231
69PRKCG0.95462937
70FRK0.93480951
71PRKCH0.91505543
72PIK3CA0.89309126
73CSNK1G20.89012878
74FGFR30.87270475
75SIK20.85325934
76MAP4K20.83830163
77EPHA40.83158644
78PRKAA20.82788569
79CSNK1G30.80750690
80CAMK2D0.80301181
81LMTK20.79529663
82MAPKAPK50.78265444
83STK110.73561591
84CAMK1G0.72381956
85PAK30.71134646
86CDK140.70583120
87CDK180.70140145
88DYRK1A0.68162647
89ROCK10.66222923
90CCNB10.62774130
91LATS20.62215106
92YES10.61932422
93HIPK20.61833850
94STK30.61803425
95CAMK40.61722634
96CDK80.61339898
97CDK150.60833196
98CDC42BPA0.60601409
99PLK40.59500082
100MYLK0.58776217
101MAP2K60.57074462
102FER0.53975466
103MAP3K70.53469275
104KSR10.52354526
105WNK10.52007311
106STK240.51455709
107CDK11A0.51151635
108PHKG20.50491923
109PHKG10.50491923
110RPS6KA20.50154685
111CAMK2G0.50047213
112MAP2K10.49501648
113RET0.49347508
114RPS6KA30.48732119
115ROCK20.48457475
116PASK0.47958910
117PRKACA0.47952714
118PDK10.45878035
119PRKACB0.44406840
120PRKD10.43817710
121BRD40.43050389
122PKN10.43023298
123PAK60.42639910
124CAMKK10.42045337
125PRKCA0.41673944
126PRKCZ0.41539438
127MUSK0.41440786
128PIK3CG0.40935642
129TESK10.40186048
130PRKACG0.40038391
131PTK2B0.39362137
132SGK10.39068808
133VRK10.38452147
134CSNK1G10.35437779
135MAP3K10.33440216
136PRKG10.33260331
137CDK30.33096916
138KSR20.32680987
139PDK30.31285455
140PDK40.31285455
141EPHA30.28741498
142FGR0.27909418
143FES0.27559722

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001903.70038677
2Synaptic vesicle cycle_Homo sapiens_hsa047213.58052068
3Collecting duct acid secretion_Homo sapiens_hsa049663.34774425
4Nicotine addiction_Homo sapiens_hsa050333.22027474
5Parkinsons disease_Homo sapiens_hsa050122.92053773
6Vibrio cholerae infection_Homo sapiens_hsa051102.69511704
7Maturity onset diabetes of the young_Homo sapiens_hsa049502.59129058
8Insulin secretion_Homo sapiens_hsa049112.43467744
9Alzheimers disease_Homo sapiens_hsa050102.34353459
10Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.27476820
11Amphetamine addiction_Homo sapiens_hsa050312.22605966
12Taste transduction_Homo sapiens_hsa047422.19267664
13Serotonergic synapse_Homo sapiens_hsa047262.16131788
14Cocaine addiction_Homo sapiens_hsa050302.07726258
15GABAergic synapse_Homo sapiens_hsa047272.07503280
16Dopaminergic synapse_Homo sapiens_hsa047282.02322257
17Protein export_Homo sapiens_hsa030602.00437381
18Huntingtons disease_Homo sapiens_hsa050161.97962826
19Morphine addiction_Homo sapiens_hsa050321.95942382
20Dilated cardiomyopathy_Homo sapiens_hsa054141.95099865
21Circadian entrainment_Homo sapiens_hsa047131.89751247
22Olfactory transduction_Homo sapiens_hsa047401.85784600
23Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.70902271
24Glutamatergic synapse_Homo sapiens_hsa047241.67421577
25Long-term potentiation_Homo sapiens_hsa047201.67396668
26Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.60753872
27Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.58504860
28Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.56294702
29Cholinergic synapse_Homo sapiens_hsa047251.53665511
30Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.53193522
31Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.45208723
32Long-term depression_Homo sapiens_hsa047301.43128106
33Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.42218027
34Cardiac muscle contraction_Homo sapiens_hsa042601.37050272
35Sulfur metabolism_Homo sapiens_hsa009201.33399247
36Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.27198326
37Tryptophan metabolism_Homo sapiens_hsa003801.27149585
38Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.26233710
39Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.25632738
40Renin secretion_Homo sapiens_hsa049241.25168840
41Rheumatoid arthritis_Homo sapiens_hsa053231.18858031
42Salivary secretion_Homo sapiens_hsa049701.14032555
43Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.12454252
44Aldosterone synthesis and secretion_Homo sapiens_hsa049251.08075960
45Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.07796153
46Phagosome_Homo sapiens_hsa041451.05608901
47Phenylalanine metabolism_Homo sapiens_hsa003601.05605505
48Type I diabetes mellitus_Homo sapiens_hsa049401.02573795
49Calcium signaling pathway_Homo sapiens_hsa040201.01899152
50SNARE interactions in vesicular transport_Homo sapiens_hsa041301.01504845
51Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.00838993
52Type II diabetes mellitus_Homo sapiens_hsa049301.00547140
53Tyrosine metabolism_Homo sapiens_hsa003500.98429803
54Phototransduction_Homo sapiens_hsa047440.92635630
55Regulation of autophagy_Homo sapiens_hsa041400.92295540
56Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.91475169
57Fatty acid degradation_Homo sapiens_hsa000710.90174318
58Bile secretion_Homo sapiens_hsa049760.89398707
59Gastric acid secretion_Homo sapiens_hsa049710.88981955
60GnRH signaling pathway_Homo sapiens_hsa049120.87821445
61Gap junction_Homo sapiens_hsa045400.86121914
62Fatty acid metabolism_Homo sapiens_hsa012120.86082129
63Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.85764447
64ABC transporters_Homo sapiens_hsa020100.84692299
65Selenocompound metabolism_Homo sapiens_hsa004500.84479283
66Oxytocin signaling pathway_Homo sapiens_hsa049210.80941571
67Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.80259860
68Proteasome_Homo sapiens_hsa030500.78822610
69Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.78145922
70Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.74790600
71Propanoate metabolism_Homo sapiens_hsa006400.74763336
72Mineral absorption_Homo sapiens_hsa049780.71857372
73beta-Alanine metabolism_Homo sapiens_hsa004100.69903710
74Estrogen signaling pathway_Homo sapiens_hsa049150.68422321
75Alcoholism_Homo sapiens_hsa050340.64943690
76Vascular smooth muscle contraction_Homo sapiens_hsa042700.64568431
77Pancreatic secretion_Homo sapiens_hsa049720.63911017
78Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.62888895
79ErbB signaling pathway_Homo sapiens_hsa040120.61582739
80cAMP signaling pathway_Homo sapiens_hsa040240.61500556
81Phosphatidylinositol signaling system_Homo sapiens_hsa040700.61312156
82Axon guidance_Homo sapiens_hsa043600.60098586
83Thyroid hormone synthesis_Homo sapiens_hsa049180.57868904
84Linoleic acid metabolism_Homo sapiens_hsa005910.57740633
85Vitamin B6 metabolism_Homo sapiens_hsa007500.57635895
86Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.57301064
87Fatty acid biosynthesis_Homo sapiens_hsa000610.57277351
88Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.54891989
89Circadian rhythm_Homo sapiens_hsa047100.54609628
90Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.52574530
91Glucagon signaling pathway_Homo sapiens_hsa049220.52287150
92Melanogenesis_Homo sapiens_hsa049160.51415323
93PPAR signaling pathway_Homo sapiens_hsa033200.51351132
94Primary bile acid biosynthesis_Homo sapiens_hsa001200.50836276
95Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.49862191
96Peroxisome_Homo sapiens_hsa041460.49264196
97alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.48722765
98Tight junction_Homo sapiens_hsa045300.48385525
99Pyruvate metabolism_Homo sapiens_hsa006200.46233349
100Carbohydrate digestion and absorption_Homo sapiens_hsa049730.46192198
101cGMP-PKG signaling pathway_Homo sapiens_hsa040220.45928878
102Hedgehog signaling pathway_Homo sapiens_hsa043400.45535742
103Arginine biosynthesis_Homo sapiens_hsa002200.43969724
104Insulin resistance_Homo sapiens_hsa049310.43850080
105Folate biosynthesis_Homo sapiens_hsa007900.43562125
106Butanoate metabolism_Homo sapiens_hsa006500.42425471
107Thyroid hormone signaling pathway_Homo sapiens_hsa049190.41611904
108AMPK signaling pathway_Homo sapiens_hsa041520.41470545
109Ovarian steroidogenesis_Homo sapiens_hsa049130.40574796
110Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.39100082
111Prion diseases_Homo sapiens_hsa050200.36980050
112Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.36961145
113African trypanosomiasis_Homo sapiens_hsa051430.36069310
114Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.33620179
115MAPK signaling pathway_Homo sapiens_hsa040100.32082021
116Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.29411776
117Prolactin signaling pathway_Homo sapiens_hsa049170.29175779
118Fatty acid elongation_Homo sapiens_hsa000620.28404876
119Glioma_Homo sapiens_hsa052140.26309432
120Ras signaling pathway_Homo sapiens_hsa040140.26134136
121Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.25070143
122Histidine metabolism_Homo sapiens_hsa003400.25030000
123Ether lipid metabolism_Homo sapiens_hsa005650.24569055
124Insulin signaling pathway_Homo sapiens_hsa049100.22455953
125Dorso-ventral axis formation_Homo sapiens_hsa043200.22192884
126Metabolic pathways_Homo sapiens_hsa011000.18809846
127Inositol phosphate metabolism_Homo sapiens_hsa005620.17068171
128Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.16797476
129N-Glycan biosynthesis_Homo sapiens_hsa005100.16776807
130Sphingolipid metabolism_Homo sapiens_hsa006000.16641257
131Wnt signaling pathway_Homo sapiens_hsa043100.15945273
132Glycerophospholipid metabolism_Homo sapiens_hsa005640.15115740
133Choline metabolism in cancer_Homo sapiens_hsa052310.13775529
134Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.13694873

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